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Wyszukujesz frazę ""Gene Expression Regulation, Enzymologic"" wg kryterium: Temat


Tytuł :
Identification, characterization and expression analyses of cholinesterases genes in Yesso scallop (Patinopecten yessoensis) reveal molecular function allocation in responses to ocean acidification.
Autorzy :
Xing Q; MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.
Liao H; MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China; College of Animal Biotechnology, Jiangxi Agricultural University, Nanchang, 330045, China.
Peng C; MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China.
Zheng G; MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China.
Yang Z; MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China.
Wang J; MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.
Lu W; MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China.
Huang X; MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China. Electronic address: .
Bao Z; MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.
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Źródło :
Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2021 Feb; Vol. 231, pp. 105736. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Enzymologic*/drug effects
Oceans and Seas*
Acids/*chemistry
Cholinesterases/*genetics
Pectinidae/*enzymology
Pectinidae/*genetics
Amino Acid Sequence ; Animals ; Cholinesterases/chemistry ; Cholinesterases/metabolism ; Genome ; Phylogeny ; Protein Domains
Czasopismo naukowe
Tytuł :
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium.
Autorzy :
Schuler BA; Department of Pediatrics.
Habermann AC; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, and.
Plosa EJ; Department of Pediatrics.
Taylor CJ; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, and.
Jetter C; Department of Pediatrics.
Negretti NM; Department of Pediatrics.
Kapp ME; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Benjamin JT; Department of Pediatrics.
Gulleman P; Department of Pediatrics.
Nichols DS; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, and.
Braunstein LZ; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Hackett A; Department of Pediatrics.
Koval M; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, Georgia, USA.
Guttentag SH; Department of Pediatrics.
Blackwell TS; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, and.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Department of Veterans Affairs Medical Center, Nashville, Tennessee, USA.
Webber SA; Department of Pediatrics.
Banovich NE; Translational Genomics Research Institute, Phoenix, Arizona, USA.
Kropski JA; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, and.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Department of Veterans Affairs Medical Center, Nashville, Tennessee, USA.
Sucre JM; Department of Pediatrics.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.
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Corporate Authors :
Vanderbilt COVID-19 Consortium Cohort
Human Cell Atlas Biological Network
Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Jan 04; Vol. 131 (1).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Alveolar Epithelial Cells/*enzymology
COVID-19/*enzymology
COVID-19/*metabolism
SARS-CoV-2/*metabolism
Serine Endopeptidases/*biosynthesis
Adult ; Aging ; Alveolar Epithelial Cells/pathology ; Alveolar Epithelial Cells/virology ; Animals ; COVID-19/pathology ; Child, Preschool ; Disease Models, Animal ; Female ; Humans ; Infant ; Male ; Mice
Czasopismo naukowe
Tytuł :
Disrupted eNOS activity and expression account for vasodilator dysfunction in different stage of sepsis.
Autorzy :
Hu S; Division of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Pi Q; Division of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Xu X; Emergency Ward, The First People's Hospital of Shangqiu, Henan 476000, China.
Yan J; Institute of Life Science, Chongqing Medical University, Chongqing 400016, China.
Guo Y; Division of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Tan W; Sichuan Academy of Chinese Medicine Science, Chengdu 610000, China.
He A; Division of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Cheng Z; Division of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Luo S; Division of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Xia Y; Division of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China; Institute of Life Science, Chongqing Medical University, Chongqing 400016, China; Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, 473 West 12(th) Avenue, Columbus, OH 43210, USA. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118606. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Nitric Oxide Synthase Type III/*biosynthesis
Sepsis/*enzymology
Sepsis/*physiopathology
Vasodilation/*physiology
Acetylcholine/pharmacology ; Animals ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/enzymology ; Aorta, Thoracic/physiopathology ; Cattle ; Dose-Response Relationship, Drug ; Human Umbilical Vein Endothelial Cells ; Humans ; Lipopolysaccharides/toxicity ; Male ; Mesenteric Arteries/drug effects ; Mesenteric Arteries/enzymology ; Mesenteric Arteries/physiopathology ; Mice ; Mice, Inbred C57BL ; Nitric Oxide Synthase Type III/genetics ; Organ Culture Techniques ; Sepsis/chemically induced ; Vasodilation/drug effects ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Tytuł :
Arginase II Plays a Central Role in the Sexual Dimorphism of Arginine Metabolism in C57BL/6 Mice.
Autorzy :
Mohammad MA; USDA/ARS (Agricultural Research Service) Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Food Science and Nutrition Department, National Research Centre, Dokki, Giza, Egypt.
Didelija IC; USDA/ARS (Agricultural Research Service) Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Marini JC; USDA/ARS (Agricultural Research Service) Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Pediatric Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
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Źródło :
The Journal of nutrition [J Nutr] 2020 Dec 10; Vol. 150 (12), pp. 3133-3140.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amino Acids/*metabolism
Arginase/*metabolism
Arginine/*metabolism
Gene Expression Regulation, Enzymologic/*drug effects
Amino Acids/pharmacology ; Animals ; Arginase/genetics ; Arginine/blood ; Arginine/pharmacology ; Citrulline/blood ; Citrulline/metabolism ; Female ; Gene Expression Regulation, Enzymologic/physiology ; Genotype ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification.
Autorzy :
Feng H; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Xing W; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Han Y; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Sun J; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Kong M; Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
Gao B; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.; Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yang Y; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Yin Z; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, China.
Chen X; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, China.
Zhao Y; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Bi Q; Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
Zou W; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.; Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Dec 01; Vol. 130 (12), pp. 6354-6365.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Signal Transduction*
Cathepsin K/*biosynthesis
Hedgehog Proteins/*metabolism
Ossification, Heterotopic/*metabolism
Stem Cells/*metabolism
Tendons/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cathepsin K/genetics ; Hedgehog Proteins/genetics ; Mice ; Mice, Transgenic ; Ossification, Heterotopic/genetics ; Ossification, Heterotopic/pathology ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Stem Cells/pathology ; Tendons/pathology
Czasopismo naukowe
Tytuł :
Curcumin inhibits CT26 cells metastasis by decreasing heparanase expression.
Autorzy :
Li S; Tianjin Key Laboratory of Early Human Development and Reproduction Regulation, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, China.
Fu H; College of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Wang Y; College of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Wang L; Pharmacy Department, Tianjin Second People's Hospital, Tianjin, China.
Jia B; College of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Bian Y; College of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Dec; Vol. 108 (6), pp. 1727-1733. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colonic Neoplasms/*immunology
Curcumin/*pharmacology
Gene Expression Regulation, Enzymologic/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Glucuronidase/*immunology
Neoplasm Proteins/*immunology
Cell Line, Tumor ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Gene Expression Regulation, Enzymologic/immunology ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/immunology ; Neoplasm Metastasis
Czasopismo naukowe
Tytuł :
MiR-21-5p directly contributes to regulating eNOS expression in human artery endothelial cells under normoxia and hypoxia.
Autorzy :
Peñaloza E; Instituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile.
Soto-Carrasco G; Instituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile.
Krause BJ; Instituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114288. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Endothelium, Vascular/*metabolism
MicroRNAs/*metabolism
Nitric Oxide Synthase Type III/*biosynthesis
Umbilical Arteries/*metabolism
Cell Hypoxia/physiology ; Cells, Cultured ; Female ; Humans ; Infant, Newborn ; Male ; MicroRNAs/antagonists & inhibitors ; Nitric Oxide Synthase Type III/genetics ; Pregnancy
Czasopismo naukowe
Tytuł :
Effects of overexpression of ACSL1 gene on the synthesis of unsaturated fatty acids in adipocytes of bovine.
Autorzy :
Zhao Z; College of Animal Science and Technology & Gansu Key Laboratory of Herbivorous Animal BiotechnologyGansu Agricultural University, Lanzhou, 730070, China. Electronic address: .
Abbas Raza SH; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, PR China.
Tian H; College of Animal Science and Technology & Gansu Key Laboratory of Herbivorous Animal BiotechnologyGansu Agricultural University, Lanzhou, 730070, China. Electronic address: .
Shi B; College of Animal Science and Technology & Gansu Key Laboratory of Herbivorous Animal BiotechnologyGansu Agricultural University, Lanzhou, 730070, China. Electronic address: .
Luo Y; College of Animal Science and Technology & Gansu Key Laboratory of Herbivorous Animal BiotechnologyGansu Agricultural University, Lanzhou, 730070, China. Electronic address: .
Wang J; College of Animal Science and Technology & Gansu Key Laboratory of Herbivorous Animal BiotechnologyGansu Agricultural University, Lanzhou, 730070, China. Electronic address: .
Liu X; College of Animal Science and Technology & Gansu Key Laboratory of Herbivorous Animal BiotechnologyGansu Agricultural University, Lanzhou, 730070, China. Electronic address: .
Li S; College of Animal Science and Technology & Gansu Key Laboratory of Herbivorous Animal BiotechnologyGansu Agricultural University, Lanzhou, 730070, China. Electronic address: .
Bai Y; College of Animal Science and Technology & Gansu Key Laboratory of Herbivorous Animal BiotechnologyGansu Agricultural University, Lanzhou, 730070, China. Electronic address: .
Hu J; College of Animal Science and Technology & Gansu Key Laboratory of Herbivorous Animal BiotechnologyGansu Agricultural University, Lanzhou, 730070, China. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Nov 30; Vol. 695, pp. 108648. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Adipocytes/*metabolism
Coenzyme A Ligases/*biosynthesis
Fatty Acids, Unsaturated/*biosynthesis
Adenoviridae ; Animals ; Cattle ; Coenzyme A Ligases/genetics ; Fatty Acids, Unsaturated/genetics ; Genetic Vectors ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
High levels of maternal total tri-iodothyronine, and low levels of fetal free L-thyroxine and total tri-iodothyronine, are associated with altered deiodinase expression and activity in placenta with gestational diabetes mellitus.
Autorzy :
Gutiérrez-Vega S; Laboratorio de Patologías del Embarazo, Departamento de Bioquímica Clínica e Inmunología, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.; Escuela de Tecnología Médica, Facultad de Ciencias de la Salud, Universidad San Sebastián, Chile.
Armella A; Laboratorio de Patologías del Embarazo, Departamento de Bioquímica Clínica e Inmunología, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.
Mennickent D; Laboratorio de Patologías del Embarazo, Departamento de Bioquímica Clínica e Inmunología, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.
Loyola M; Laboratorio de Patologías del Embarazo, Departamento de Bioquímica Clínica e Inmunología, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.; Escuela de Tecnología Médica, Facultad de Ciencias de la Salud, Universidad San Sebastián, Chile.
Covarrubias A; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.; Group of Research and Innovation in Vascular Health (GRIVAS-Health), Chillán, Chile.
Ortega-Contreras B; Laboratorio de Patologías del Embarazo, Departamento de Bioquímica Clínica e Inmunología, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.
Escudero C; Group of Research and Innovation in Vascular Health (GRIVAS-Health), Chillán, Chile.; Vascular Physiology Laboratory, Department of Basic Sciences, Universidad del Bío-Bío, Chillán, Chile.
Gonzalez M; Group of Research and Innovation in Vascular Health (GRIVAS-Health), Chillán, Chile.; Laboratorio de Investigación Materno-Fetal (LIMaF), Departamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Concepción, Concepción, Chile.
Alcalá M; Facultad de Farmacia, Universidad CEU San Pablo, Ctra, Boadilla Km 5, Alcorcón, Madrid, Spain.
Ramos MDP; Facultad de Farmacia, Universidad CEU San Pablo, Ctra, Boadilla Km 5, Alcorcón, Madrid, Spain.
Viana M; Facultad de Farmacia, Universidad CEU San Pablo, Ctra, Boadilla Km 5, Alcorcón, Madrid, Spain.
Castro E; Departamento de Obstetricia y Puericultura, Facultad de Ciencias de la Salud, Universidad de Atacama, Atacama, Chile.
Leiva A; Escuela de Tecnología Médica, Facultad de Ciencias de la Salud, Universidad San Sebastián, Chile.
Guzmán-Gutiérrez E; Laboratorio de Patologías del Embarazo, Departamento de Bioquímica Clínica e Inmunología, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.; Group of Research and Innovation in Vascular Health (GRIVAS-Health), Chillán, Chile.
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Źródło :
PloS one [PLoS One] 2020 Nov 24; Vol. 15 (11), pp. e0242743. Date of Electronic Publication: 2020 Nov 24 (Print Publication: 2020).
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Diabetes, Gestational/*blood
Iodide Peroxidase/*biosynthesis
Placenta/*metabolism
Thyroxine/*blood
Triiodothyronine/*blood
Adult ; Diabetes, Gestational/pathology ; Female ; Humans ; Placenta/pathology ; Pregnancy
Czasopismo naukowe
Tytuł :
Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression.
Autorzy :
Zhang X; Department of Neonatology, Tianjin Medical University, Tianjin, P.R. China.
Wang C; Department of Cardiology, Tianjin Fifth Central Hospital, Tianjin, P.R. China.
Zhao D; Department of Neonatology, The Second Hospital of Tianjin Medical University, Tianjin, P.R. China.
Chen X; Department of Obstetrics and Gynecology, Tianjin Fifth Central Hospital, Tianjin, P.R. China.
Zhang C; Department of Pharmacy, Tianjin Binhai New Area Hospital of Traditional Chinese Medicine, Tianjin, P.R. China.
Zheng J; Department of Neonatology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, P.R. China.
Liu X; Central Laboratory, The Fifth Central Hospital of Tianjin, Tianjin, P.R. China.
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Źródło :
PloS one [PLoS One] 2020 Nov 19; Vol. 15 (11), pp. e0242606. Date of Electronic Publication: 2020 Nov 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Gene Expression Regulation*
Gene Expression Regulation, Enzymologic*
Induced Pluripotent Stem Cells/*metabolism
Myocardium/*enzymology
Myocytes, Cardiac/*enzymology
Peptide Hydrolases/*biosynthesis
Zinc/*deficiency
Animals ; Cell Line ; Female ; Humans ; Induced Pluripotent Stem Cells/pathology ; Male ; Mice ; Myocardium/pathology ; Myocytes, Cardiac/pathology ; SUMO-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity.
Autorzy :
Link JC; Molecular Biology Institute.
Wiese CB; Human Genetics, David Geffen School of Medicine.
Chen X; Integrative Biology and Physiology, and.
Avetisyan R; Human Genetics, David Geffen School of Medicine.
Ronquillo E; Human Genetics, David Geffen School of Medicine.
Ma F; Molecular, Cellular and Developmental Biology, UCLA, Los Angeles, California, USA.
Guo X; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Yao J; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Allison M; Division of Preventive Medicine, School of Medicine, UCSD, San Diego, California, USA.
Chen YI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Rotter JI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
El-Sayed Moustafa JS; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Iwase S; Human Genetics, Medical School, University of Michigan, Ann Arbor, Michigan, USA.
Pellegrini M; Molecular, Cellular and Developmental Biology, UCLA, Los Angeles, California, USA.
Vergnes L; Human Genetics, David Geffen School of Medicine.
Arnold AP; Integrative Biology and Physiology, and.
Reue K; Molecular Biology Institute.; Human Genetics, David Geffen School of Medicine.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Nov 02; Vol. 130 (11), pp. 5688-5702.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adiposity*
Gene Dosage*
Gene Expression Regulation, Enzymologic*
Histone Demethylases*/biosynthesis
Histone Demethylases*/genetics
Sex Characteristics*
X Chromosome*/genetics
X Chromosome*/metabolism
Adipocytes/*enzymology
Animals ; Chromatin Assembly and Disassembly ; Female ; Humans ; Male ; Mice ; Mice, Mutant Strains
Czasopismo naukowe
Tytuł :
Leptin, Resistin, and Proprotein Convertase Subtilisin/Kexin Type 9: The Role of STAT3.
Autorzy :
Macchi C; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy. Electronic address: .
Greco MF; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Botta M; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Sperandeo P; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Dongiovanni P; General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Valenti L; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Translational Medicine, Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Cicero AFG; Department of Medicine and Surgery Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Borghi C; Department of Medicine and Surgery Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Lupo MG; Department of Pharmaceutical and Pharmacological Sciences, Università degli Studi di Padova, Padova, Italy.
Romeo S; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Science, Magna Graecia University, Catanzaro, Italy; Department of Cardiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Corsini A; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy; IRCCS MultiMedica, Sesto S. Giovanni, Milan, Italy.
Magni P; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy; IRCCS MultiMedica, Sesto S. Giovanni, Milan, Italy.
Ferri N; Department of Pharmaceutical and Pharmacological Sciences, Università degli Studi di Padova, Padova, Italy.
Ruscica M; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2020 Nov; Vol. 190 (11), pp. 2226-2236. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Up-Regulation*
Leptin/*metabolism
Proprotein Convertase 9/*biosynthesis
Resistin/*metabolism
STAT3 Transcription Factor/*metabolism
Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Hep G2 Cells ; Humans ; Leptin/genetics ; Obesity/genetics ; Obesity/metabolism ; Obesity/pathology ; Proprotein Convertase 9/genetics ; Resistin/genetics ; Response Elements ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover.
Autorzy :
Alexander KL; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Serrano CA; Departments of Pediatric Gastroenterology and Nutrition, Pontificia Universidad Catolica de Chile, Santiago, Chile.
Chakraborty A; Department of Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Nearing M; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Council LN; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Riquelme A; Department of Gastroenterologys, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Department Health Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile.
Garrido M; Department of Oncology, Pontificia Universidad Catolica de Chile, Santiago, Chile.
Bellis SL; Department of Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Smythies LE; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA .
Smith PD; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Oct 09; Vol. 295 (41), pp. 14153-14163. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Gene Expression Regulation, Neoplastic*
Homeostasis*
Antigens, CD/*biosynthesis
Epithelial Cells/*metabolism
Neoplasm Proteins/*biosynthesis
Organoids/*metabolism
Sialyltransferases/*biosynthesis
Stomach Neoplasms/*epidemiology
Antigens, CD/genetics ; Cell Line ; Epithelial Cells/pathology ; Humans ; Neoplasm Proteins/genetics ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Organoids/pathology ; SOX9 Transcription Factor/genetics ; SOX9 Transcription Factor/metabolism ; Sialyltransferases/genetics ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Relationship between clinicopathological characteristics and CYLD expression in patients with cholesteatoma.
Autorzy :
Miyake S; Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.; Department of Pharmacy, Kumamoto University Hospital, Kumamoto, Japan.
Miwa T; Department of Otolaryngology-Head and Neck Surgery, Kyoto University, Kyoto, Japan.; Department of Otolaryngology-Head and Neck Surgery, Tazuke Kofukai Medical Research Institute Kitano Hospital, Osaka, Japan.
Yoneda G; Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, United States of America.
Kanemaru A; Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
Saito H; Department of Otolaryngology-Head and Neck Surgery, Kumamoto University Hospital, Kumamoto, Japan.
Minoda R; Department of Otolaryngology-Head and Neck Surgery, Kumamoto General Hospital, Kumamoto, Japan.
Orita Y; Department of Otolaryngology-Head and Neck Surgery, Kumamoto University Hospital, Kumamoto, Japan.
Saito H; Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.; Department of Pharmacy, Kumamoto University Hospital, Kumamoto, Japan.
Jono H; Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.; Department of Pharmacy, Kumamoto University Hospital, Kumamoto, Japan.
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Źródło :
PloS one [PLoS One] 2020 Oct 08; Vol. 15 (10), pp. e0240216. Date of Electronic Publication: 2020 Oct 08 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Cholesteatoma/*metabolism
Cholesteatoma/*pathology
Deubiquitinating Enzyme CYLD/*metabolism
Adolescent ; Adult ; Aged ; Cholesteatoma/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Prognosis
Czasopismo naukowe
Tytuł :
Survivin in breast cancer-derived exosomes activates fibroblasts by up-regulating SOD1, whose feedback promotes cancer proliferation and metastasis.
Autorzy :
Li K; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Liu T; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Chen J; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Ni H; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Li W; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Oct 02; Vol. 295 (40), pp. 13737-13752. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Gene Expression Regulation, Enzymologic*
Up-Regulation*
Breast Neoplasms/*metabolism
Exosomes/*metabolism
Fibroblasts/*metabolism
Neoplasm Proteins/*metabolism
Superoxide Dismutase-1/*biosynthesis
Survivin/*metabolism
Animals ; Breast Neoplasms/pathology ; Exosomes/pathology ; Female ; Fibroblasts/pathology ; Humans ; MCF-7 Cells ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Metastasis
Czasopismo naukowe
Tytuł :
Deletion of bglC triggers a genetic compensation response by awakening the expression of alternative beta-glucosidase.
Autorzy :
Deflandre B; InBioS - Center for Protein Engineering, University of Liège, Institut de Chimie, Liège B-4000, Belgium.
Thiébaut N; InBioS - Center for Protein Engineering, University of Liège, Institut de Chimie, Liège B-4000, Belgium.
Planckaert S; Laboratory of Microbiology, Protein Research Unit, Department of Biochemistry and Microbiology, Ghent University, Ghent B-9000, Belgium.
Jourdan S; InBioS - Center for Protein Engineering, University of Liège, Institut de Chimie, Liège B-4000, Belgium.
Anderssen S; InBioS - Center for Protein Engineering, University of Liège, Institut de Chimie, Liège B-4000, Belgium.
Hanikenne M; InBioS-PhytoSystems, Functional Genomics and Plant Molecular Imaging, University of Liège, 4000 Liège, Belgium.
Devreese B; Laboratory of Microbiology, Protein Research Unit, Department of Biochemistry and Microbiology, Ghent University, Ghent B-9000, Belgium.
Francis I; Department of Biology, California State University, Bakersfield 93311, CA, USA.
Rigali S; InBioS - Center for Protein Engineering, University of Liège, Institut de Chimie, Liège B-4000, Belgium. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2020 Oct; Vol. 1863 (10), pp. 194615. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Deletion*
Gene Expression Regulation, Bacterial*
Gene Expression Regulation, Enzymologic*
Phenotype*
Bacterial Proteins/*genetics
beta-Glucosidase/*genetics
Bacterial Proteins/metabolism ; Enzyme Activation ; Isoenzymes ; Models, Biological ; Models, Molecular ; Protein Conformation ; Structure-Activity Relationship ; Transcriptional Activation ; beta-Glucosidase/chemistry ; beta-Glucosidase/metabolism
Czasopismo naukowe
Tytuł :
Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation.
Autorzy :
Ghiroldi A; Laboratory of Stem Cells for Tissue Engineering, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Piccoli M; Laboratory of Stem Cells for Tissue Engineering, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Creo P; Laboratory of Stem Cells for Tissue Engineering, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Cirillo F; Laboratory of Stem Cells for Tissue Engineering, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Rota P; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
D'Imperio S; Laboratory of Stem Cells for Tissue Engineering, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.; Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.; Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Ciconte G; Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Monasky MM; Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Micaglio E; Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Garatti A; Department of Cardiovascular Disease 'E. Malan', Cardiac Surgery Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Aureli M; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Carsana EV; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Menicanti L; Department of Cardiovascular Disease 'E. Malan', Cardiac Surgery Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Pappone C; Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.; University of Vita-Salute San Raffaele, Milan, Italy.
Anastasia L; Laboratory of Stem Cells for Tissue Engineering, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.; University of Vita-Salute San Raffaele, Milan, Italy.
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Źródło :
The Biochemical journal [Biochem J] 2020 Sep 18; Vol. 477 (17), pp. 3401-3415.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Up-Regulation*
Fibroblasts/*metabolism
G(M3) Ganglioside/*metabolism
Myocardium/*metabolism
Neuraminidase/*biosynthesis
Fibroblasts/pathology ; Fibrosis ; Humans ; Myocardium/pathology ; Receptor, Transforming Growth Factor-beta Type I/metabolism
Czasopismo naukowe
Tytuł :
Nerve growth factor from Indian Russell's viper venom (RVV-NGFa) shows high affinity binding to TrkA receptor expressed in breast cancer cells: Application of fluorescence labeled RVV-NGFa in the clinical diagnosis of breast cancer.
Autorzy :
Islam T; Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, 784028, Assam, India.
Majumder M; Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, 784028, Assam, India.
Bidkar A; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India.
Ghosh SS; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India.
Mukhopadhyay R; Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, 784028, Assam, India.
Utkin Y; Laboratory of the Molecular Toxinology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, Russia.
Mukherjee AK; Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, 784028, Assam, India. Electronic address: .
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Źródło :
Biochimie [Biochimie] 2020 Sep; Vol. 176, pp. 31-44. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/diagnostic imaging
Breast Neoplasms*/enzymology
Gene Expression Regulation, Enzymologic*
Gene Expression Regulation, Neoplastic*
Nanoparticles*
Nerve Growth Factor*/chemistry
Nerve Growth Factor*/pharmacology
Optical Imaging*
Viper Venoms*/chemistry
Viper Venoms*/pharmacology
Neoplasm Proteins/*biosynthesis
Receptor, trkA/*biosynthesis
Animals ; Female ; Fluorescein-5-isothiocyanate/chemistry ; Fluorescein-5-isothiocyanate/pharmacology ; HEK293 Cells ; Humans ; MCF-7 Cells ; PC12 Cells ; Rats ; Staining and Labeling
Czasopismo naukowe
Tytuł :
Overlapping and distinct roles of CDPK family members in the pre-erythrocytic stages of the rodent malaria parasite, Plasmodium berghei.
Autorzy :
Govindasamy K; Rutgers New Jersey Medical School, Department of Microbiology, Biochemistry and Molecular Genetics, Newark, New Jersey, United States of America.
Bhanot P; Rutgers New Jersey Medical School, Department of Microbiology, Biochemistry and Molecular Genetics, Newark, New Jersey, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Aug 31; Vol. 16 (8), pp. e1008131. Date of Electronic Publication: 2020 Aug 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Down-Regulation*
Gene Expression Regulation, Enzymologic*
Malaria/*epidemiology
Merozoites/*enzymology
Plasmodium berghei/*enzymology
Protein Kinases/*biosynthesis
Protozoan Proteins/*biosynthesis
Sporozoites/*enzymology
Animals ; Erythrocytes/enzymology ; Erythrocytes/parasitology ; Female ; Hep G2 Cells ; Humans ; Liver/enzymology ; Liver/parasitology ; Malaria/pathology ; Mice
Czasopismo naukowe
Tytuł :
Nitrogen Regulating the Expression and Localization of Four Glutamine Synthetase Isoforms in Wheat ( Triticum aestivum L.).
Autorzy :
Wei Y; Collaborative Innovation Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University, Zhengzhou 450000, China.
Wang X; Collaborative Innovation Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University, Zhengzhou 450000, China.; Department of Biochemistry and Molecular Biology, College of Life Science, Henan Agricultural University, Zhengzhou 450000, China.
Zhang Z; Collaborative Innovation Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University, Zhengzhou 450000, China.
Xiong S; Collaborative Innovation Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University, Zhengzhou 450000, China.
Meng X; Collaborative Innovation Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University, Zhengzhou 450000, China.
Zhang J; Collaborative Innovation Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University, Zhengzhou 450000, China.
Wang L; Collaborative Innovation Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University, Zhengzhou 450000, China.
Zhang X; Collaborative Innovation Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University, Zhengzhou 450000, China.
Yu M; Department of Biochemistry and Molecular Biology, College of Life Science, Henan Agricultural University, Zhengzhou 450000, China.
Ma X; Collaborative Innovation Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University, Zhengzhou 450000, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 31; Vol. 21 (17). Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Gene Expression Regulation, Plant*
Glutamate-Ammonia Ligase/*metabolism
Nitrogen/*metabolism
Plant Proteins/*metabolism
Triticum/*enzymology
Glutamate-Ammonia Ligase/genetics ; Isoenzymes ; Plant Leaves/enzymology ; Plant Proteins/genetics
Czasopismo naukowe

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