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Wyszukujesz frazę ""Gene Expression Regulation, Leukemic"" wg kryterium: Temat


Tytuł :
RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia.
Autorzy :
Grinev VV; Department of Genetics, Faculty of Biology, Belarusian State University, 220030, Minsk, Republic of Belarus. .
Barneh F; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands.
Ilyushonak IM; Department of Genetics, Faculty of Biology, Belarusian State University, 220030, Minsk, Republic of Belarus.
Nakjang S; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Smink J; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands.
van Oort A; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands.
Clough R; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Seyani M; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
McNeill H; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Reza M; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Martinez-Soria N; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Assi SA; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Ramanouskaya TV; Department of Genetics, Faculty of Biology, Belarusian State University, 220030, Minsk, Republic of Belarus.
Bonifer C; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Heidenreich O; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands. .; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. .; Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 22; Vol. 12 (1), pp. 520. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Gene Expression Regulation, Leukemic*
Core Binding Factor Alpha 2 Subunit/*genetics
Leukemia, Myeloid/*genetics
Oncogene Proteins, Fusion/*genetics
RUNX1 Translocation Partner 1 Protein/*genetics
Acute Disease ; Cell Line, Tumor ; Core Binding Factor Alpha 2 Subunit/metabolism ; Gene Expression Profiling/methods ; Humans ; Leukemia, Myeloid/pathology ; Models, Genetic ; Oncogene Proteins, Fusion/metabolism ; RNA Interference ; RNA Isoforms/genetics ; RNA Isoforms/metabolism ; RUNX1 Translocation Partner 1 Protein/metabolism ; Transcription Initiation Site
Czasopismo naukowe
Tytuł :
Haploidentical vs matched unrelated donor transplantation for acute myeloid leukemia in remission: A prospective comparative study.
Autorzy :
Cho BS; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Min GJ; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Park S; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Park SS; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Shin SH; Department of Hematology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Yahng SA; Department of Hematology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Jeon YW; Department of Hematology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Yoon JH; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Lee SE; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Eom KS; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kim YJ; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Lee S; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Min CK; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Cho SG; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kim DW; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Lee JW; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kim M; Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kim Y; Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kim HJ; Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
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Źródło :
American journal of hematology [Am J Hematol] 2021 Jan; Vol. 96 (1), pp. 98-109. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Leukemic*
Hematopoietic Stem Cell Transplantation*
Leukemia, Myeloid, Acute*/metabolism
Leukemia, Myeloid, Acute*/mortality
Leukemia, Myeloid, Acute*/pathology
Leukemia, Myeloid, Acute*/therapy
WT1 Proteins/*blood
Adolescent ; Adult ; Aged ; Allografts ; Chronic Disease ; Disease-Free Survival ; Female ; Follow-Up Studies ; Graft vs Host Disease ; Humans ; Male ; Middle Aged ; Prospective Studies ; Survival Rate ; Unrelated Donors
Czasopismo naukowe
Tytuł :
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.
Autorzy :
Godfrey L; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Crump NT; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
O'Byrne S; Department of Paediatrics, University of Oxford, Oxford, UK.
Lau IJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Rice S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Harman JR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Jackson T; Department of Paediatrics, University of Oxford, Oxford, UK.
Elliott N; Department of Paediatrics, University of Oxford, Oxford, UK.
Buck G; Department of Paediatrics, University of Oxford, Oxford, UK.
Connor C; Great Ormond Street Hospital for Children, London, UK.
Thorne R; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Knapp DJHF; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Heidenreich O; Princess Maxima Centrum for Pediatric Oncology, Utrecht, The Netherlands.; Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, UK.
Vyas P; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Menendez P; Josep Carreras Leukemia Research Institute, Barcelona, Spain.; Institucio Catalana of Recerca i Estudis Avançats (ICREA), Barcelona, Spain.; Centro de Investigación Biomédica en Red en cancer (CIBERONC)-ISCIII, Barcelona, Spain.
Inglott S; Great Ormond Street Hospital for Children, London, UK.
Ancliff P; Great Ormond Street Hospital for Children, London, UK.
Geng H; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.
Roberts I; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Paediatrics, University of Oxford, Oxford, UK.
Roy A; Department of Paediatrics, University of Oxford, Oxford, UK. .
Milne TA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. .
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Źródło :
Leukemia [Leukemia] 2021 Jan; Vol. 35 (1), pp. 90-106. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enhancer Elements, Genetic*
Gene Expression Regulation, Leukemic*
Promoter Regions, Genetic*
AC133 Antigen/*genetics
Histones/*metabolism
Myeloid-Lymphoid Leukemia Protein/*genetics
Neoplastic Stem Cells/*metabolism
Oncogene Proteins, Fusion/*genetics
Biomarkers, Tumor ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Gene Silencing ; Humans ; Immunophenotyping ; Leukemia/genetics ; Leukemia/metabolism ; Models, Biological ; Protein Binding
Czasopismo naukowe
Tytuł :
Ectonucleotidase CD39 is highly expressed on ATLL cells and is responsible for their immunosuppressive function.
Autorzy :
Nagate Y; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Ezoe S; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan. .; Department of Environmental Space Infection Control, Osaka University Graduate School of Medicine, Suita, Japan. .
Fujita J; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Okuzaki D; Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Motooka D; Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Ishibashi T; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Ichii M; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Tanimura A; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Kurashige M; Department of Pathology, Osaka University Graduate School of Medicine, Osaka University, Suita, Japan.
Morii E; Department of Pathology, Osaka University Graduate School of Medicine, Osaka University, Suita, Japan.
Fukushima T; Laboratory of Hematoimmunology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Nishihara, Japan.
Suehiro Y; Department of Hematology, National Kyushu Cancer, Fukuoka, Japan.
Yokota T; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Shibayama H; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Oritani K; Department of Hematology, Graduate School of Medical Sciences, International University of Health and Welfare Hospital, Narita, Japan.
Kanakura Y; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
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Źródło :
Leukemia [Leukemia] 2021 Jan; Vol. 35 (1), pp. 107-118. Date of Electronic Publication: 2020 Mar 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Leukemic*
Antigens, CD/*genetics
Apyrase/*genetics
Immune Tolerance/*genetics
Immunomodulation/*genetics
Leukemia-Lymphoma, Adult T-Cell/*genetics
Leukemia-Lymphoma, Adult T-Cell/*immunology
Adenosine Triphosphate/metabolism ; Animals ; Antigens, CD/metabolism ; Apyrase/metabolism ; Biomarkers ; Cell Line, Tumor ; Disease Models, Animal ; Gene Expression Profiling ; Gene Knockdown Techniques ; Heterografts ; High-Throughput Nucleotide Sequencing ; Humans ; Immunophenotyping ; Leukemia-Lymphoma, Adult T-Cell/diagnosis ; Leukemia-Lymphoma, Adult T-Cell/metabolism ; Mice ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocyte Subsets/pathology
Czasopismo naukowe
Tytuł :
LncRNA PTENP1 inhibits cervical cancer progression by suppressing miR-106b.
Autorzy :
Fan Y; Department of Oncology, Taikang Xianlin Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, P.R. China.
Sheng W; Department of Oncology, Taikang Xianlin Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, P.R. China.
Meng Y; Department of Oncology, Taikang Xianlin Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, P.R. China.
Cao Y; Department of Oncology, Taikang Xianlin Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, P.R. China.
Li R; Department of Oncology, Taikang Xianlin Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, P.R. China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 393-407.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Apoptosis*
Gene Expression Regulation, Leukemic*
Genes, Tumor Suppressor*
RNA, Long Noncoding/*biosynthesis
RNA, Neoplasm/*biosynthesis
Uterine Cervical Neoplasms/*metabolism
Female ; HeLa Cells ; Humans ; MicroRNAs ; RNA, Long Noncoding/genetics ; RNA, Neoplasm/genetics ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology
Czasopismo naukowe
Tytuł :
TACC3 expression as a prognostic factor in aggressive types of adult T-cell leukemia/lymphoma patients.
Autorzy :
Moritsubo M; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Miyoshi H; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Matsuda K; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.; Department of Orthopedic surgery, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Yoshida N; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.; Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Hiroshima, Japan.
Nakashima K; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Yanagida E; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Yamada K; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Takeuchi M; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Suzuki T; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Muta H; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Umeno T; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Furuta T; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Seto M; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
Ohshima K; Department of Pathology, Kurume University School of medicine, Kurume, Fukuoka, Japan.
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Źródło :
International journal of laboratory hematology [Int J Lab Hematol] 2020 Dec; Vol. 42 (6), pp. 842-848. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Leukemic*
Leukemia-Lymphoma, Adult T-Cell*/metabolism
Leukemia-Lymphoma, Adult T-Cell*/mortality
Leukemia-Lymphoma, Adult T-Cell*/pathology
Microtubule-Associated Proteins/*biosynthesis
Neoplasm Proteins/*biosynthesis
Adult ; Aged ; Aged, 80 and over ; Cell Line, Tumor ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Survival Rate
Czasopismo naukowe
Tytuł :
PCAT18, as a novel differentially regulated long noncoding RNA in adult acute myeloid leukemia patients revealed by next-generation sequencing.
Autorzy :
Zhang J; Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.
Zhang H; Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.
Wang X; Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.
Zhao Y; Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.
Fu Y; Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.
Liu X; Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.
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Źródło :
International journal of laboratory hematology [Int J Lab Hematol] 2020 Dec; Vol. 42 (6), pp. 858-865. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Leukemic*
High-Throughput Nucleotide Sequencing*
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/metabolism
RNA, Long Noncoding*/biosynthesis
RNA, Long Noncoding*/genetics
RNA, Neoplasm*/biosynthesis
RNA, Neoplasm*/genetics
Aged ; Female ; G1 Phase/genetics ; Humans ; K562 Cells ; Male ; Middle Aged ; S Phase/genetics ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Diagnostic, prognostic and predictive values of miR-100 and miR-210 in pediatric acute lymphoblastic Leukemia.
Autorzy :
Hassan NM; Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Refaat LA; Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Ismail GN; Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Abdellateif M; Medical Biochemistry and Molecular Biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Fadel SA; Pediatric Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
AbdelAziz RS; Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
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Źródło :
Hematology (Amsterdam, Netherlands) [Hematology] 2020 Dec; Vol. 25 (1), pp. 405-413.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Down-Regulation*
Gene Expression Regulation, Leukemic*
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/mortality
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/pathology
MicroRNAs/*biosynthesis
RNA, Neoplasm/*biosynthesis
Adolescent ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Humans ; Infant ; Male ; Predictive Value of Tests ; Survival Rate
Czasopismo naukowe
Tytuł :
Covalent inhibition of NSD1 histone methyltransferase.
Autorzy :
Huang H; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Howard CA; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA.
Zari S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Cho HJ; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Shukla S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Li H; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA.
Ndoj J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
González-Alonso P; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Nikolaidis C; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Abbott J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Rogawski DS; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Potopnyk MA; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Kempinska K; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Miao H; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Purohit T; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Henderson A; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Mapp A; Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA.; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Sulis ML; Department of Pediatric Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ferrando A; Institute for Cancer Genetics, Columbia University, New York, NY, USA.; Department of Systems Biology, Columbia University, New York, NY, USA.; Department of Pathology & Cell Biology, Columbia University, New York, NY, USA.; Department of Pediatrics, Columbia University, New York, NY, USA.
Grembecka J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA. .; Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA. .
Cierpicki T; Department of Pathology, University of Michigan, Ann Arbor, MI, USA. .; Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA. .; Department of Biophysics, University of Michigan, Ann Arbor, MI, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2020 Dec; Vol. 16 (12), pp. 1403-1410. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Leukemic*
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Histone-Lysine N-Methyltransferase/*antagonists & inhibitors
Leukocytes/*drug effects
Nuclear Pore Complex Proteins/*genetics
Oncogene Proteins, Fusion/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Binding Sites ; Enzyme Inhibitors/chemical synthesis ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Kinetics ; Leukemia/drug therapy ; Leukemia/enzymology ; Leukemia/genetics ; Leukemia/pathology ; Leukocytes/enzymology ; Leukocytes/pathology ; Models, Molecular ; Myeloid Ecotropic Viral Integration Site 1 Protein/genetics ; Myeloid Ecotropic Viral Integration Site 1 Protein/metabolism ; Nuclear Pore Complex Proteins/metabolism ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Signal Transduction ; Substrate Specificity ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia.
Autorzy :
Nagel S; Department of Human and Animal Cell Lines, Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
Pommerenke C; Department of Human and Animal Cell Lines, Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
Meyer C; Department of Human and Animal Cell Lines, Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
MacLeod RAF; Department of Human and Animal Cell Lines, Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
Drexler HG; Department of Human and Animal Cell Lines, Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
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Źródło :
PloS one [PLoS One] 2020 Oct 13; Vol. 15 (10), pp. e0240120. Date of Electronic Publication: 2020 Oct 13 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Leukemic*
Homeodomain Proteins/*genetics
Leukemia, Myeloid, Acute/*genetics
Cell Differentiation ; Cell Line, Tumor ; Humans ; Leukemia, Myeloid, Acute/pathology ; Transcriptome
Czasopismo naukowe
Tytuł :
Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature.
Autorzy :
Fitch B; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.
Roy R; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; Computational Biology and Informatics, University of California, San Francisco, San Francisco, CA.
Geng H; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA.
Montecino-Rodriguez E; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.
Bengtsson H; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
Gaillard C; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA.
Hiam K; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.
Casero D; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.
Olshen AB; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; Computational Biology and Informatics, University of California, San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
Dorshkind K; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA.
Kogan SC; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA. Electronic address: .
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Źródło :
Experimental hematology [Exp Hematol] 2020 Oct; Vol. 90, pp. 65-71.e1. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Profiling*
Gene Expression Regulation, Leukemic*
Neoplasm Proteins*/biosynthesis
Neoplasm Proteins*/genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/classification
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/metabolism
Transcriptome*
Animals ; Child ; Humans ; Mice
Czasopismo naukowe
Tytuł :
"Caught in the net": the extracellular matrix of the bone marrow in normal hematopoiesis and leukemia.
Autorzy :
Zanetti C; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Krause DS; German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Germany; Frankfurt Cancer Institute, Frankfurt, Germany; Faculty of Medicine, Johann Wolfgang Goethe University, Frankfurt, Germany. Electronic address: .
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Źródło :
Experimental hematology [Exp Hematol] 2020 Sep; Vol. 89, pp. 13-25. Date of Electronic Publication: 2020 Aug 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Gene Expression Regulation, Leukemic*
Bone Marrow/*metabolism
Extracellular Matrix/*genetics
Extracellular Matrix Proteins/*genetics
Leukemia/*genetics
Neoplastic Stem Cells/*metabolism
Antineoplastic Agents/therapeutic use ; Bone Marrow/drug effects ; Bone Marrow/pathology ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/pathology ; Disease Progression ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Extracellular Matrix Proteins/metabolism ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/pathology ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Leukemia/drug therapy ; Leukemia/metabolism ; Leukemia/pathology ; Neoplastic Stem Cells/pathology ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł :
Loss of surface CD3 expression in allogeneic CAR T-cells.
Autorzy :
Margolskee E; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Pillai V; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
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Źródło :
American journal of hematology [Am J Hematol] 2020 Sep; Vol. 95 (9), pp. 1115-1116. Date of Electronic Publication: 2020 Mar 20.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Gene Expression Regulation, Leukemic*
Immunotherapy, Adoptive*
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/blood
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/pathology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/therapy
T-Lymphocytes*/metabolism
T-Lymphocytes*/pathology
T-Lymphocytes*/transplantation
CD3 Complex/*blood
Neoplasm Proteins/*blood
Receptors, Chimeric Antigen/*blood
Allografts ; Child, Preschool ; Female ; Humans ; Infant ; Male
Czasopismo naukowe
Tytuł :
Heritable genetic background alters survival and phenotype of Mll-AF9-induced leukemias.
Autorzy :
Young K; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME.
Loberg MA; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME.
Eudy E; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME.
Schwartz LS; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME.
Mujica KD; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME.
Trowbridge JJ; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME. Electronic address: .
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Źródło :
Experimental hematology [Exp Hematol] 2020 Sep; Vol. 89, pp. 61-67.e3. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Leukemic*
Carcinogenesis/*genetics
Leukemia, Biphenotypic, Acute/*genetics
Leukemia, Myeloid, Acute/*genetics
Myeloproliferative Disorders/*genetics
Oncogene Proteins, Fusion/*genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Animals ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Lineage/genetics ; Disease Progression ; Female ; Gene Knock-In Techniques ; Genetic Predisposition to Disease ; Humans ; Leukemia, Biphenotypic, Acute/metabolism ; Leukemia, Biphenotypic, Acute/mortality ; Leukemia, Biphenotypic, Acute/pathology ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/pathology ; Lymphocyte Count ; Lymphocytes/metabolism ; Lymphocytes/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Inbred Strains ; Mice, Transgenic ; Myeloid Cells/metabolism ; Myeloid Cells/pathology ; Myeloproliferative Disorders/metabolism ; Myeloproliferative Disorders/mortality ; Myeloproliferative Disorders/pathology ; Oncogene Proteins, Fusion/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/mortality ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Survival Analysis
Czasopismo naukowe
Tytuł :
A novel transgenic mouse strain expressing PKCβII demonstrates expansion of B1 and marginal zone B cell populations.
Autorzy :
Azar AA; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 1st Floor Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.; Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Michie AM; Molecular Lymphopoiesis Group, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Tarafdar A; Molecular Lymphopoiesis Group, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Malik N; Molecular Lymphopoiesis Group, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Menon GK; Department of Histopathology, Royal Liverpool University Hospital, Liverpool, UK.
Till KJ; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 1st Floor Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.
Vlatković N; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 1st Floor Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK. .
Slupsky JR; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 1st Floor Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 04; Vol. 10 (1), pp. 13156. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Gene Expression Regulation, Leukemic*
B-Lymphocytes/*enzymology
Leukemia, Lymphocytic, Chronic, B-Cell/*enzymology
Neoplasm Proteins/*biosynthesis
Protein Kinase C beta/*biosynthesis
Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; B-Lymphocytes/pathology ; Immunoglobulin D/genetics ; Immunoglobulin D/metabolism ; Immunoglobulin M/genetics ; Immunoglobulin M/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Mice ; Mice, Transgenic ; Neoplasm Proteins/genetics ; Protein Kinase C beta/genetics ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Gene expression workflow to analyze residual leukemic cells in Chronic Lymphocytic Leukemia.
Autorzy :
Mora A; Laboratory of Oncology/Hematology and Transplantation, Biomedical Research Institute, IIB Sant Pau, Barcelona, Spain.; Department of Hematology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain.; Deparment of Medicine, Autonomous University of Barcelona, Barcelona, Spain.; Joseph Carreras Leukemia Research Institute, Barcelona, Spain.
Bosch R; Laboratory of Oncology/Hematology and Transplantation, Biomedical Research Institute, IIB Sant Pau, Barcelona, Spain.; Department of Hematology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain.
Cuellar-García C; Laboratory of Oncology/Hematology and Transplantation, Biomedical Research Institute, IIB Sant Pau, Barcelona, Spain.; Department of Hematology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain.; Joseph Carreras Leukemia Research Institute, Barcelona, Spain.
Blanco L; Laboratory of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Sierra J; Laboratory of Oncology/Hematology and Transplantation, Biomedical Research Institute, IIB Sant Pau, Barcelona, Spain.; Department of Hematology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain.; Deparment of Medicine, Autonomous University of Barcelona, Barcelona, Spain.; Laboratory of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Nomdedeu J; Laboratory of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Moreno C; Laboratory of Oncology/Hematology and Transplantation, Biomedical Research Institute, IIB Sant Pau, Barcelona, Spain.; Department of Hematology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain.; Deparment of Medicine, Autonomous University of Barcelona, Barcelona, Spain.
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Źródło :
International journal of laboratory hematology [Int J Lab Hematol] 2020 Aug; Vol. 42 (4), pp. 423-430. Date of Electronic Publication: 2020 Apr 25.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Flow Cytometry*
Gene Expression Profiling*
Gene Expression Regulation, Leukemic*
Workflow*
Leukemia, Lymphocytic, Chronic, B-Cell/*blood
Leukocytes/*metabolism
Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy ; Leukocytes/pathology ; Male ; Neoplasm, Residual
Czasopismo naukowe
Tytuł :
LncRNA MEG3 contributes to drug resistance in acute myeloid leukemia by positively regulating ALG9 through sponging miR-155.
Autorzy :
Yu Y; College of Laboratory Medicine, Dalian Medical University, Dalian, China.; Department of Emergency, Affiliated Dalian Friend-ship Hospital of Dalian Medical University, Dalian, China.
Kou D; Department of Clinical Laboratory, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
Liu B; College of Laboratory Medicine, Dalian Medical University, Dalian, China.
Huang Y; College of Laboratory Medicine, Dalian Medical University, Dalian, China.
Li S; College of Laboratory Medicine, Dalian Medical University, Dalian, China.
Qi Y; College of Laboratory Medicine, Dalian Medical University, Dalian, China.
Guo Y; College of Laboratory Medicine, Dalian Medical University, Dalian, China.
Huang T; College of Laboratory Medicine, Dalian Medical University, Dalian, China.
Qi X; College of Laboratory Medicine, Dalian Medical University, Dalian, China.
Jia L; College of Laboratory Medicine, Dalian Medical University, Dalian, China.
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Źródło :
International journal of laboratory hematology [Int J Lab Hematol] 2020 Aug; Vol. 42 (4), pp. 464-472. Date of Electronic Publication: 2020 May 02.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Gene Expression Regulation, Leukemic*
Leukemia, Myeloid, Acute/*metabolism
Mannosyltransferases/*biosynthesis
Membrane Proteins/*biosynthesis
MicroRNAs/*metabolism
Neoplasm Proteins/*biosynthesis
RNA, Long Noncoding/*metabolism
RNA, Neoplasm/*metabolism
Female ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Male ; Mannosyltransferases/genetics ; Membrane Proteins/genetics ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; RNA, Long Noncoding/genetics ; RNA, Neoplasm/genetics ; THP-1 Cells ; U937 Cells
Czasopismo naukowe
Tytuł :
MNDA controls the expression of MCL-1 and BCL-2 in chronic lymphocytic leukemia cells.
Autorzy :
Bottardi S; Maisonneuve-Rosemont Hospital Research Center, University of Montreal, CIUSSS de l'Est-de-l'Île de Montréal, Montreal, QC, Canada.
Guieze R; CHU Clermont-Ferrand, Unit of Adult Cell Therapy and Clinical Haematology, Clermont-Ferrand, France; Université Clermont Auvergne, Clermont-Ferrand Cedex, France.
Bourgoin V; Maisonneuve-Rosemont Hospital Research Center, University of Montreal, CIUSSS de l'Est-de-l'Île de Montréal, Montreal, QC, Canada.
Fotouhi-Ardakani N; Maisonneuve-Rosemont Hospital Research Center, University of Montreal, CIUSSS de l'Est-de-l'Île de Montréal, Montreal, QC, Canada.
Dougé A; CHU Clermont-Ferrand, Unit of Adult Cell Therapy and Clinical Haematology, Clermont-Ferrand, France.
Darracq A; Maisonneuve-Rosemont Hospital Research Center, University of Montreal, CIUSSS de l'Est-de-l'Île de Montréal, Montreal, QC, Canada.
Lakehal YA; Maisonneuve-Rosemont Hospital Research Center, University of Montreal, CIUSSS de l'Est-de-l'Île de Montréal, Montreal, QC, Canada; Department of Medicine, University of Montréal, Montréal, QC, Canada.
Berger MG; CHU Clermont-Ferrand, Unit of Adult Cell Therapy and Clinical Haematology, Clermont-Ferrand, France; Université Clermont Auvergne, Clermont-Ferrand Cedex, France.
Mollica L; Maisonneuve-Rosemont Hospital Research Center, University of Montreal, CIUSSS de l'Est-de-l'Île de Montréal, Montreal, QC, Canada; Department of Medicine, University of Montréal, Montréal, QC, Canada.
Bay JO; CHU Clermont-Ferrand, Unit of Adult Cell Therapy and Clinical Haematology, Clermont-Ferrand, France; Université Clermont Auvergne, Clermont-Ferrand Cedex, France.
Omichinski JG; Department of Biochemistry, University of Montréal, Montréal, QC, Canada.
Milot E; Maisonneuve-Rosemont Hospital Research Center, University of Montreal, CIUSSS de l'Est-de-l'Île de Montréal, Montreal, QC, Canada; Department of Medicine, University of Montréal, Montréal, QC, Canada. Electronic address: .
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Źródło :
Experimental hematology [Exp Hematol] 2020 Aug; Vol. 88, pp. 68-82.e5. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Leukemic*
Antigens, Differentiation, Myelomonocytic/*metabolism
Leukemia, Lymphocytic, Chronic, B-Cell/*metabolism
Myeloid Cell Leukemia Sequence 1 Protein/*biosynthesis
Proto-Oncogene Proteins c-bcl-2/*biosynthesis
Transcription Factors/*metabolism
Aged ; Aged, 80 and over ; Antigens, Differentiation, Myelomonocytic/genetics ; Apoptosis/genetics ; Chromatin/genetics ; Chromatin/metabolism ; Female ; HL-60 Cells ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Male ; Middle Aged ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML.
Autorzy :
Toda J; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Ichii M; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan. .
Oritani K; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Hematology, Graduate School of Medical Science, International University of Health and Welfare, Narita, Japan.
Shibayama H; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Tanimura A; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Saito H; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Yokota T; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Motooka D; Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Okuzaki D; Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Kitai Y; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Muromoto R; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Kashiwakura JI; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Matsuda T; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Hosen N; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Kanakura Y; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.; Sumitomo Hospital, Osaka, Japan.
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Źródło :
Oncogene [Oncogene] 2020 Aug; Vol. 39 (34), pp. 5601-5615. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Gene Expression Regulation, Leukemic*
Adaptor Proteins, Signal Transducing/*genetics
Apoptosis/*genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
Neoplastic Stem Cells/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cell Line, Tumor ; Fusion Proteins, bcr-abl/genetics ; Fusion Proteins, bcr-abl/metabolism ; Gene Expression Profiling/methods ; Humans ; K562 Cells ; Kaplan-Meier Estimate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplastic Stem Cells/pathology ; Protein Binding ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients.
Autorzy :
Lauber C; Institute for Medical Informatics and Biometry (IMB), Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Correia N; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Trumpp A; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Rieger MA; Department of Medicine, Hematology/Oncology, Goethe University Hospital Frankfurt, Frankfurt, Germany.
Dolnik A; Department of Hematology, Oncology and Tumorimmunology, Charité University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany.
Bullinger L; Department of Hematology, Oncology and Tumorimmunology, Charité University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany.
Roeder I; Institute for Medical Informatics and Biometry (IMB), Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), Dresden, Germany.
Seifert M; Institute for Medical Informatics and Biometry (IMB), Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany. .; National Center for Tumor Diseases (NCT), Dresden, Germany. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 29; Vol. 10 (1), pp. 12761. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Leukemic*
DNA (Cytosine-5-)-Methyltransferases/*genetics
Leukemia, Myeloid, Acute/*genetics
Leukemia, Myeloid, Acute/*mortality
Adolescent ; Adult ; Aged ; Clinical Trials as Topic ; Cluster Analysis ; DNA Mutational Analysis ; Gene Expression Profiling ; Humans ; Kaplan-Meier Estimate ; MicroRNAs/genetics ; Middle Aged ; Mutation ; Nuclear Proteins/genetics ; Oligonucleotide Array Sequence Analysis ; Prognosis ; Remission Induction ; Survival Analysis ; Treatment Outcome ; Up-Regulation ; Young Adult ; fms-Like Tyrosine Kinase 3/genetics
Czasopismo naukowe

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