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Wyszukujesz frazę ""Gene Expression Regulation, Neoplastic"" wg kryterium: Temat


Tytuł :
Overexpression of FUBP1 is associated with human cervical carcinoma development and prognosis.
Autorzy :
Ma C; Reproductive Medical Center, Guangzhou Women and Children's Medical Center of Sun Yat-sen University, Guangzhou, Guangdong, China.
Huang Z; Department of Biochemistry, Zhongshan School of Medicine, SunYat-sen University, Guangzhou, China.
Wu Z; Department of Clinical Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China.
Di C; Department of Clinical Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China.
Lin X; Department of Clinical Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China.
Huang M; Department of Clinical Laboratory, Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, Guangdong, China. Electronic address: .
Hong H; Department of Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: .
Yin H; Department of Clinical Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119098. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
DNA-Binding Proteins/*metabolism
RNA-Binding Proteins/*metabolism
Uterine Cervical Neoplasms/*pathology
Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; DNA-Binding Proteins/genetics ; Female ; Humans ; Middle Aged ; Prognosis ; RNA-Binding Proteins/genetics ; Survival Rate ; Tumor Cells, Cultured ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Exosome-mediated delivery of functionally active miRNA-375-3p mimic regulate epithelial mesenchymal transition (EMT) of colon cancer cells.
Autorzy :
Rezaei R; Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Baghaei K; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: .
Amani D; Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: .
Piccin A; Haematology Dept, Our Lady's Children's Hospital, Dublin, Ireland; Dept of Internal Medicine V, University of Innsbruck, Innsbruck, Austria.
Hashemi SM; Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Asadzadeh Aghdaei H; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zali MR; Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119035. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*genetics
Colonic Neoplasms/*pathology
Exosomes/*genetics
MicroRNAs/*genetics
Neoplastic Stem Cells/*pathology
Apoptosis ; Biomarkers, Tumor/metabolism ; Biomimetics ; Cell Movement ; Cell Proliferation ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Humans ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; Neoplastic Stem Cells/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
High expression of MYEOV reflects poor prognosis in non-small cell lung cancer.
Autorzy :
Zhang R; Department of Thoracic Surgery, Linyi Tumor Hospital, Linyi City, Shandong Province, PR China.
Ma A; Department of Operating Room, Linyi Tumor Hospital, Linyi City, Shandong Province, PR China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Feb 20; Vol. 770, pp. 145337. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/metabolism
Carcinoma, Non-Small-Cell Lung*/mortality
Gene Expression Regulation, Neoplastic*
Lung Neoplasms*/genetics
Lung Neoplasms*/metabolism
Lung Neoplasms*/mortality
Proto-Oncogene Proteins*/biosynthesis
Proto-Oncogene Proteins*/genetics
Disease-Free Survival ; Female ; Humans ; Male ; Survival Rate
Czasopismo naukowe
Tytuł :
PFKFB4 promotes lung adenocarcinoma progression via phosphorylating and activating transcriptional coactivator SRC-2.
Autorzy :
Meng J; Department of Respiratory Medicine, Sixth Medical Center of Chinese People's Liberation Army General Hospital, Beijing, 100048, China.
Chen X; Department of Respiratory Medicine, Sixth Medical Center of Chinese People's Liberation Army General Hospital, Beijing, 100048, China.
Han Z; Department of Respiratory Medicine, Sixth Medical Center of Chinese People's Liberation Army General Hospital, Beijing, 100048, China. .
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Źródło :
BMC pulmonary medicine [BMC Pulm Med] 2021 Feb 16; Vol. 21 (1), pp. 60. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Adenocarcinoma of Lung/*genetics
Lung Neoplasms/*genetics
Nuclear Receptor Coactivator 2/*genetics
Phosphofructokinase-2/*genetics
A549 Cells ; Adenocarcinoma of Lung/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Disease Progression ; Gene Expression Profiling ; HEK293 Cells ; Humans ; Lung Neoplasms/pathology ; Neoplasm Invasiveness/genetics ; Phosphorylation ; Transcriptional Activation/genetics
Czasopismo naukowe
Tytuł :
Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma.
Autorzy :
Liu J; The province and ministry co-sponsored collaborative innovation center for medical epigenetics; Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
Xie Y; The province and ministry co-sponsored collaborative innovation center for medical epigenetics; Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
Guo J; The province and ministry co-sponsored collaborative innovation center for medical epigenetics; Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
Li X; The province and ministry co-sponsored collaborative innovation center for medical epigenetics; Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
Wang J; The province and ministry co-sponsored collaborative innovation center for medical epigenetics; Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
Jiang H; The province and ministry co-sponsored collaborative innovation center for medical epigenetics; Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
Peng Z; The province and ministry co-sponsored collaborative innovation center for medical epigenetics; Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
Wang J; The province and ministry co-sponsored collaborative innovation center for medical epigenetics; Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
Wang S; The province and ministry co-sponsored collaborative innovation center for medical epigenetics; Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
Li Q; Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Tianjin Key Laboratory of Cancer Prevention and Therapy; Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Ye L; Center for Translational Research in Hematological Malignancies, Cancer Center, Houston Methodist Hospital, Houston, TX, USA.
Zhong Y; Department of Hematology, Myeloma Research Center of Beijing, Beijing Chao-Yang Hospital, Capital Medical University, Chaoyang, Beijing, China.
Zhang Q; Department of Hematology, the Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Liu X; Central Laboratory, Tianjin Key Laboratory of Epigenetics for Organ Development of Premature Infants, The Fifth Central Hospital of Tianjin, Tianjin, China.
Lonard DM; Department of Molecular and Cellular Biology, Baylor College of Medicine, Baylor College of Medicine, Houston, TX, USA.
Wang J; Department of Pharmacology and Chemical Biology, Houston, TX, USA.
O'Malley BW; Department of Molecular and Cellular Biology, Baylor College of Medicine, Baylor College of Medicine, Houston, TX, USA. .
Liu Z; The province and ministry co-sponsored collaborative innovation center for medical epigenetics; Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China. .; Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Tianjin Key Laboratory of Cancer Prevention and Therapy; Tianjin's Clinical Research Center for Cancer, Tianjin, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 15; Vol. 12 (1), pp. 1022. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Drug Resistance, Neoplasm/*drug effects
Enzyme Inhibitors/*pharmacology
Histone-Lysine N-Methyltransferase/*genetics
Multiple Myeloma/*drug therapy
Nuclear Receptor Coactivator 3/*genetics
Repressor Proteins/*genetics
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Apoptosis/genetics ; Bone and Bones/drug effects ; Bone and Bones/metabolism ; Bone and Bones/pathology ; Bortezomib/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 4 ; Drug Resistance, Neoplasm/genetics ; Female ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Male ; Middle Aged ; Multiple Myeloma/genetics ; Multiple Myeloma/mortality ; Multiple Myeloma/pathology ; Nuclear Receptor Coactivator 3/antagonists & inhibitors ; Nuclear Receptor Coactivator 3/metabolism ; Proteasome Inhibitors/pharmacology ; Recurrence ; Repressor Proteins/metabolism ; Signal Transduction ; Survival Analysis ; Translocation, Genetic ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma.
Autorzy :
Bakouny Z; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Braun DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Shukla SA; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.
Pan W; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Gao X; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Hou Y; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.
Flaifel A; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Tang S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Bosma-Moody A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
He MX; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Vokes N; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Nyman J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Xie W; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.
Nassar AH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Abou Alaiwi S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Flippot R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Bouchard G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Steinharter JA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Nuzzo PV; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Ficial M; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Sant'Angelo M; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Forman J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Berchuck JE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Dudani S; Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.
Bi K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Park J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Camp S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Sticco-Ivins M; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Hirsch L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Baca SC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Wind-Rotolo M; Bristol-Myers Squibb, Princeton, NJ, USA.
Ross-Macdonald P; Bristol-Myers Squibb, Princeton, NJ, USA.
Sun M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Lee GM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Chang SL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Wei XX; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
McGregor BA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Harshman LC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Genovese G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ellis L; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Pomerantz M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Hirsch MS; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Freedman ML; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Atkins MB; Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ho TH; Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ, USA.
Linehan WM; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
McDermott DF; Beth Israel Deaconess Medical Center, Boston, MA, USA.
Heng DYC; Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.
Viswanathan SR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Signoretti S; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. .
Choueiri TK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 05; Vol. 12 (1), pp. 808. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Antineoplastic Agents, Immunological/*therapeutic use
Carcinoma, Renal Cell/*immunology
Immune Checkpoint Inhibitors/*therapeutic use
Immune Checkpoint Proteins/*immunology
Kidney Neoplasms/*immunology
Rhabdoid Tumor/*immunology
B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/genetics ; B7-H1 Antigen/immunology ; CTLA-4 Antigen/antagonists & inhibitors ; CTLA-4 Antigen/genetics ; CTLA-4 Antigen/immunology ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/mortality ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/immunology ; Gene Expression Profiling ; High-Throughput Nucleotide Sequencing ; Humans ; Immune Checkpoint Proteins/genetics ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics ; Kidney Neoplasms/mortality ; Mutation ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/immunology ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/immunology ; Retrospective Studies ; Rhabdoid Tumor/drug therapy ; Rhabdoid Tumor/genetics ; Rhabdoid Tumor/mortality ; Signal Transduction ; Survival Analysis ; Transcription, Genetic ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/immunology ; Ubiquitin Thiolesterase/genetics ; Ubiquitin Thiolesterase/immunology
Czasopismo naukowe
Tytuł :
A Urine Exosome Gene Expression Panel Distinguishes between Indolent and Aggressive Prostate Cancers at Biopsy.
Autorzy :
Kohaar I; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.; Henry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, Maryland.
Chen Y; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.
Banerjee S; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.
Borbiev T; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.; Henry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, Maryland.
Kuo HC; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.; Henry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, Maryland.
Ali A; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.
Ravindranath L; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.
Kagan J; Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland.
Srivastava S; Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland.
Dobi A; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.; Henry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, Maryland.
Sesterhenn IA; Joint Pathology Center, Silver Spring, Maryland.
Rosner IL; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.
Cullen J; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.
Srivastava S; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.
Petrovics G; Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland.; Henry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, Maryland.
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Źródło :
The Journal of urology [J Urol] 2021 Feb; Vol. 205 (2), pp. 420-425. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Exosomes/*genetics
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*pathology
Adult ; Aged ; Aged, 80 and over ; Biopsy ; Cohort Studies ; Diagnosis, Differential ; Humans ; Male ; Middle Aged ; Prostatic Neoplasms/urine
Czasopismo naukowe
Tytuł :
C8orf48 inhibits the tumorigenesis of colorectal cancer by regulating the MAPK signaling pathway.
Autorzy :
Lei L; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China. Electronic address: .
An G; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Zhu Z; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Liu S; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Fu Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Zeng X; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Cao Q; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Yan B; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118872. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
MAP Kinase Signaling System*
Biomarkers, Tumor/*metabolism
Carcinogenesis/*pathology
Colorectal Neoplasms/*pathology
MicroRNAs/*genetics
Neoplasm Proteins/*metabolism
Apoptosis ; Biomarkers, Tumor/genetics ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Movement ; Cell Proliferation ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Humans ; Neoplasm Invasiveness ; Neoplasm Proteins/genetics ; Prognosis ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Circ-UBR1 facilitates proliferation, metastasis, and inhibits apoptosis in breast cancer by regulating the miR-1299/CCND1 axis.
Autorzy :
Zhang L; Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address: .
Sun D; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhang J; Department of Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Tian Y; Department of Breast Surgery, Huaihe Hospital of Henan University, Kaifeng, Henan, China.
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118829. Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Breast Neoplasms/*pathology
Cyclin D1/*metabolism
MicroRNAs/*genetics
RNA, Circular/*genetics
Ubiquitin-Protein Ligases/*genetics
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Movement ; Cell Proliferation ; Cyclin D1/genetics ; Disease Progression ; Female ; Humans ; Lymphatic Metastasis ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Prognosis ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Prognostic Impact of IGF2BP3 Expression in Patients with Surgically Resected Lung Adenocarcinoma.
Autorzy :
Guo W; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Huai Q; Department of Graduate School, Zunyi Medical University, Zunyi, People's Republic of China.
Wan H; PET-CT Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Guo L; Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Song P; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Gao S; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
He J; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2021 Feb; Vol. 40 (2), pp. 316-331. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Adenocarcinoma of Lung/*diagnosis
Adenocarcinoma of Lung/*genetics
RNA-Binding Proteins/*genetics
Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/surgery ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Protein Interaction Maps
Czasopismo naukowe
Tytuł :
Serum factor(s) from lung adenocarcinoma patients regulates the molecular clock expression.
Autorzy :
Chang Y; Department of Respiration, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.; Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Zhao C; Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.; Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing, 100053, People's Republic of China.; National Clinical Research Center for Geriatric Disorders, Beijing, 100053, People's Republic of China.
Ding H; Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.; Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing, 100053, People's Republic of China.
Wang T; Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.; Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing, 100053, People's Republic of China.
Yang C; Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.; Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing, 100053, People's Republic of China.
Nie X; Department of Respiration, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Cai Y; Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China. .; Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing, 100053, People's Republic of China. .; National Clinical Research Center for Geriatric Disorders, Beijing, 100053, People's Republic of China. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Feb; Vol. 147 (2), pp. 493-498. Date of Electronic Publication: 2020 Nov 21.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Adenocarcinoma of Lung/*blood
Circadian Rhythm Signaling Peptides and Proteins/*genetics
Lung Neoplasms/*blood
ARNTL Transcription Factors/genetics ; Aged ; Cell Line ; Cryptochromes/genetics ; Female ; Humans ; Male ; Middle Aged ; Period Circadian Proteins/genetics
Czasopismo naukowe
Tytuł :
De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands.
Autorzy :
Masalmeh RHA; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.
Taglini F; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK.
Rubio-Ramon C; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK.
Musialik KI; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK.
Higham J; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.
Davidson-Smith H; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.
Kafetzopoulos I; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK.
Pawlicka KP; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK.
Finan HM; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK.
Clark R; Edinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, UK.
Wills J; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK.
Finch AJ; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK.; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Murphy L; Edinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, UK.
Sproul D; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK. .; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 29; Vol. 12 (1), pp. 694. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Gene Expression Regulation, Neoplastic*
Colorectal Neoplasms/*genetics
DNA (Cytosine-5-)-Methyltransferases/*metabolism
Histone Code/*genetics
Carcinogenesis/genetics ; Cell Line, Tumor ; Chromatin Immunoprecipitation Sequencing ; Colon/pathology ; Colorectal Neoplasms/pathology ; CpG Islands/genetics ; DNA (Cytosine-5-)-Methyltransferases/genetics ; Datasets as Topic ; Epigenesis, Genetic ; Gene Knockout Techniques ; Histones/genetics ; Humans ; Promoter Regions, Genetic/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
NUPR1 is a critical repressor of ferroptosis.
Autorzy :
Liu J; The Third Affiliated Hospital, Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, 510600, Guangdong, China.
Song X; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Kuang F; The Third Affiliated Hospital, Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, 510600, Guangdong, China.
Zhang Q; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Xie Y; Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Kang R; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Kroemer G; Université Paris Descartes, Sorbonne Paris Cité, 75006, Paris, France. .; Equipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France. .; Institut National de la Santé et de la Recherche Médicale, U1138, Paris, France. .; Université Pierre et Marie Curie, 75006, Paris, France. .; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, 94800, Villejuif, France. .; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015, Paris, France. .; Department of Women's and Children's Health, Karolinska University Hospital, 17176, Stockholm, Sweden. .
Tang D; The Third Affiliated Hospital, Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, 510600, Guangdong, China. .; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 28; Vol. 12 (1), pp. 647. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
DNA-Binding Proteins/*genetics
Ferroptosis/*genetics
Iron/*metabolism
Lipocalin-2/*genetics
Neoplasm Proteins/*genetics
Pancreatic Neoplasms/*genetics
Animals ; Cell Line, Tumor ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/metabolism ; Humans ; Kaplan-Meier Estimate ; Lipocalin-2/metabolism ; Mice, Knockout ; Mice, Nude ; Mice, Transgenic ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/metabolism ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/therapy ; Piperazines/pharmacology ; RNAi Therapeutics/methods ; Signal Transduction/genetics ; Thiazines/pharmacology ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Circular RNA 100146 Promotes Colorectal Cancer Progression by the MicroRNA 149/HMGA2 Axis.
Autorzy :
Liu K; Department of General Surgery, Rizhao People's Hospital, Rizhao City, China.
Mou Y; Department of General Surgery, Rizhao People's Hospital, Rizhao City, China.
Shi X; Department of Pediatrics, Chinese Medicine Hospital, Rizhao City, China.
Liu T; Rizhao City Tuberculosis Control Center, Rizhao City, China.
Chen Z; Department of General Surgery, Rizhao People's Hospital, Rizhao City, China.
Zuo X; Department of General Surgery, Rizhao People's Hospital, Rizhao City, China .
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2021 Jan 25; Vol. 41 (2). Date of Electronic Publication: 2021 Jan 25 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Colorectal Neoplasms/*genetics
HMGA2 Protein/*genetics
MicroRNAs/*genetics
RNA, Circular/*genetics
Aged ; Animals ; Antagomirs/genetics ; Antagomirs/metabolism ; Base Pairing ; Base Sequence ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Disease Progression ; Female ; Genes, Reporter ; HMGA2 Protein/antagonists & inhibitors ; HMGA2 Protein/metabolism ; Humans ; Luciferases/genetics ; Luciferases/metabolism ; Male ; Mice ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/metabolism ; Middle Aged ; Neoplasm Invasiveness ; RNA, Circular/antagonists & inhibitors ; RNA, Circular/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
NRF2-Dependent Bioactivation of Mitomycin C as a Novel Strategy To Target KEAP1-NRF2 Pathway Activation in Human Cancer.
Autorzy :
Baird L; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan .
Yamamoto M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan .; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2021 Jan 25; Vol. 41 (2). Date of Electronic Publication: 2021 Jan 25 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Antineoplastic Agents/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Kelch-Like ECH-Associated Protein 1/*genetics
Mitomycin/*pharmacology
NADP/*metabolism
NF-E2-Related Factor 2/*genetics
Cell Line, Tumor ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Doxorubicin/pharmacology ; Drug Resistance, Neoplasm/genetics ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; Kelch-Like ECH-Associated Protein 1/deficiency ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; NAD(P)H Dehydrogenase (Quinone)/genetics ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; NADPH-Ferrihemoprotein Reductase/genetics ; NADPH-Ferrihemoprotein Reductase/metabolism ; NF-E2-Related Factor 2/deficiency ; Oxidative Stress ; Paclitaxel/pharmacology ; Pentose Phosphate Pathway/drug effects ; Pentose Phosphate Pathway/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium.
Autorzy :
Horiuchi M; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Taguchi K; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Hirose W; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Tsuchida K; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.
Suzuki M; Center for Radioisotope Sciences, Tohoku University, Sendai, Japan.
Taniyama Y; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Kamei T; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Yamamoto M; Department of Medical Biochemistry, Tohoku University, Sendai, Japan .; Department of Medical Biochemistry, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2021 Jan 25; Vol. 41 (2). Date of Electronic Publication: 2021 Jan 25 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
4-Nitroquinoline-1-oxide/*pharmacology
Carcinogenesis/*genetics
Carcinogens/*pharmacology
Esophageal Neoplasms/*genetics
NF-E2-Related Factor 2/*genetics
Alleles ; Animals ; Carcinogenesis/chemically induced ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; DNA Damage ; Epithelium/drug effects ; Epithelium/metabolism ; Epithelium/pathology ; Esophageal Neoplasms/chemically induced ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophagus/drug effects ; Esophagus/metabolism ; Esophagus/pathology ; Genes, Reporter ; Integrases/genetics ; Integrases/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Male ; Mice ; Mice, Knockout ; NF-E2-Related Factor 2/deficiency ; Oxidative Stress ; Signal Transduction ; Tamoxifen/pharmacology
Czasopismo naukowe
Tytuł :
Prediction and analysis of hub genes between glioblastoma and low-grade glioma using bioinformatics analysis.
Autorzy :
Xu B; Department of Neurosurgery, Xintai people's Hospital Affiliated to Shandong First Medical University, PR China.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Jan 22; Vol. 100 (3), pp. e23513.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Brain Neoplasms/*genetics
Glioblastoma/*genetics
Glioma/*genetics
Gene Regulatory Networks ; Genetic Markers/genetics ; Humans
Czasopismo naukowe
Tytuł :
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition.
Autorzy :
Rinaldi G; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Pranzini E; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.
Van Elsen J; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Broekaert D; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Funk CM; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Thalkirchner Strasse 36, 80337 Munich, Germany; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Planque M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Doglioni G; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Altea-Manzano P; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Rossi M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Geldhof V; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium.
Teoh ST; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Ross C; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Hunter KW; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Lunt SY; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Thalkirchner Strasse 36, 80337 Munich, Germany; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Jan 21; Vol. 81 (2), pp. 386-397.e7. Date of Electronic Publication: 2020 Dec 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Breast Neoplasms/*genetics
Lung Neoplasms/*genetics
Mammary Neoplasms, Experimental/*genetics
Mechanistic Target of Rapamycin Complex 1/*genetics
Phosphoglycerate Dehydrogenase/*genetics
Serine/*biosynthesis
Animals ; Antibiotics, Antineoplastic/pharmacology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm ; Female ; Humans ; Ketoglutaric Acids/metabolism ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mechanistic Target of Rapamycin Complex 1/antagonists & inhibitors ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Monocarboxylic Acid Transporters/genetics ; Monocarboxylic Acid Transporters/metabolism ; Phosphoglycerate Dehydrogenase/antagonists & inhibitors ; Phosphoglycerate Dehydrogenase/metabolism ; Pyruvic Acid/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Sirolimus/pharmacology
Czasopismo naukowe
Tytuł :
Short H2A histone variants are expressed in cancer.
Autorzy :
Chew GL; The Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Bleakley M; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Bradley RK; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Genome Sciences, University of Washington, Seattle, WA, USA.
Malik HS; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Henikoff S; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Molaro A; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. .; Genetics, Reproduction and Development (GReD) Institute, Université Clermont Auvergne, Clermont-Ferrand, France. .
Sarthy J; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 20; Vol. 12 (1), pp. 490. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Histones/*genetics
Histones/*metabolism
Neoplasms/*genetics
Neoplasms/*metabolism
Alternative Splicing ; Animals ; Chromatin ; Epigenomics ; Female ; Genomics ; Humans ; Nucleosomes ; Placenta ; Pregnancy ; Up-Regulation
Czasopismo naukowe
Tytuł :
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair.
Autorzy :
Shafi AA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
McNair CM; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
McCann JJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.; Duke University, Durham, NC, 27708, USA.
Alshalalfa M; Department of Radiation Oncology, University of California at San Francisco, San Francisco, CA, 94115, USA.
Shostak A; Biochemistry Center, University of Heidelberg, Heidelberg, Germany.
Severson TM; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Zhu Y; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Bergman A; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Gordon N; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Mandigo AC; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Chand SN; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Gallagher P; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Dylgjeri E; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Laufer TS; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Vasilevskaya IA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Schiewer MJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.; Department of Urology, Medical Oncology and Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
Brunner M; Biochemistry Center, University of Heidelberg, Heidelberg, Germany.
Feng FY; Department of Radiation Oncology, University of California at San Francisco, San Francisco, CA, 94115, USA.
Zwart W; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Knudsen KE; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA. .; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA. .; Department of Urology, Medical Oncology and Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 15; Vol. 12 (1), pp. 401. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Carcinogenesis/*genetics
Cryptochromes/*metabolism
Prostatic Neoplasms, Castration-Resistant/*genetics
Recombinational DNA Repair/*genetics
Aged ; Androgen Receptor Antagonists/pharmacology ; Androgen Receptor Antagonists/therapeutic use ; Androgens/metabolism ; Carcinogenesis/drug effects ; Cell Line, Tumor ; Chromatin Immunoprecipitation Sequencing ; Cryptochromes/genetics ; DNA Breaks, Double-Stranded/drug effects ; Datasets as Topic ; Disease Progression ; Follow-Up Studies ; G2 Phase Cell Cycle Checkpoints/genetics ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Promoter Regions, Genetic/genetics ; Prospective Studies ; Prostate/pathology ; Prostate/surgery ; Prostatectomy ; Prostatic Neoplasms, Castration-Resistant/mortality ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostatic Neoplasms, Castration-Resistant/therapy ; RNA-Seq ; Receptors, Androgen/metabolism ; Recombinational DNA Repair/drug effects ; Retrospective Studies
Czasopismo naukowe

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