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Wyszukujesz frazę ""Gene Expression Regulation, Neoplastic"" wg kryterium: Temat


Tytuł:
Identification of candidate biomarkers for GBM based on WGCNA.
Autorzy:
Sun Q; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, 571199, Hainan, China.
Wang Z; Biotechnology and Biochemistry Laboratory, Hainan Medical University, Haikou, 571199, Hainan, China.
Xiu H; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, 571199, Hainan, China.
He N; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, 571199, Hainan, China.
Liu M; School of Stomatology, Hainan Medical University, Haikou, 571199, Hainan, China.
Yin L; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, 571199, Hainan, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 May 10; Vol. 14 (1), pp. 10692. Date of Electronic Publication: 2024 May 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/pathology
Glioblastoma*/metabolism
Biomarkers, Tumor*/genetics
Biomarkers, Tumor*/metabolism
Gene Regulatory Networks*
Brain Neoplasms*/genetics
Brain Neoplasms*/pathology
Brain Neoplasms*/metabolism
Gene Expression Regulation, Neoplastic*
Gene Expression Profiling*
Humans ; Gene Ontology ; Computational Biology/methods
Czasopismo naukowe
Tytuł:
Cetuximab inhibits colorectal cancer development through inactivating the Wnt/β-catenin pathway and modulating PLCB3 expression.
Autorzy:
Zhang X; Fengxian District Center Hospital Graduate Student Training Base, Jinzhou Medical University, No. 6600 Nanfeng Road, Shanghai, 201499, China.; Endoscopy Center, Minhang Hospital, Fudan University, No. 170 Xinsong Road, Shanghai, 201199, China.
Zhou W; Endoscopy Center, Minhang Hospital, Fudan University, No. 170 Xinsong Road, Shanghai, 201199, China.
Wu C; Endoscopy Center, Minhang Hospital, Fudan University, No. 170 Xinsong Road, Shanghai, 201199, China.
Jiang J; Endoscopy Center, Minhang Hospital, Fudan University, No. 170 Xinsong Road, Shanghai, 201199, China.
Guo Q; Fengxian District Center Hospital Graduate Student Training Base, Jinzhou Medical University, No. 6600 Nanfeng Road, Shanghai, 201499, China.
Feng L; Endoscopy Center, Minhang Hospital, Fudan University, No. 170 Xinsong Road, Shanghai, 201199, China. fengli_.
Cheng X; Endoscopy Center, Minhang Hospital, Fudan University, No. 170 Xinsong Road, Shanghai, 201199, China. chengxun_mh_.
Zhang X; Fengxian District Center Hospital Graduate Student Training Base, Jinzhou Medical University, No. 6600 Nanfeng Road, Shanghai, 201499, China. .; Department of Gastroenterology, Shanghai Jiaotong University Affiliated Sixth People Hospital South Campus, No. 6600 Nanfeng Road, Shanghai, 201499, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 May 09; Vol. 14 (1), pp. 10642. Date of Electronic Publication: 2024 May 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/metabolism
Colorectal Neoplasms*/pathology
Cetuximab*/pharmacology
Wnt Signaling Pathway*/drug effects
Gene Expression Regulation, Neoplastic*/drug effects
Cell Proliferation*/drug effects
beta Catenin*/metabolism
beta Catenin*/genetics
Humans ; Cell Line, Tumor ; Cell Movement/drug effects ; Prognosis ; Antineoplastic Agents, Immunological/pharmacology
Czasopismo naukowe
Tytuł:
Downregulation of RCN1 inhibits esophageal squamous cell carcinoma progression and M2 macrophage polarization.
Autorzy:
Guo H; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Shu J; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Hu G; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Liu B; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Li J; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Sun J; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Wang X; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Liu H; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Xiong S; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Tang Y; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Yin Y; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Wang X; Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.; Digestive Endoscopy Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
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Źródło:
PloS one [PLoS One] 2024 May 07; Vol. 19 (5), pp. e0302780. Date of Electronic Publication: 2024 May 07 (Print Publication: 2024).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Esophageal Squamous Cell Carcinoma*/genetics
Esophageal Squamous Cell Carcinoma*/pathology
Esophageal Squamous Cell Carcinoma*/metabolism
Esophageal Neoplasms*/pathology
Esophageal Neoplasms*/genetics
Esophageal Neoplasms*/metabolism
Epithelial-Mesenchymal Transition*/genetics
Down-Regulation*
Calcium-Binding Proteins*/metabolism
Calcium-Binding Proteins*/genetics
Gene Expression Regulation, Neoplastic*
Humans ; Female ; Male ; Cell Line, Tumor ; Middle Aged ; Cell Movement/genetics ; Disease Progression ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/pathology ; Apoptosis ; Prognosis ; Macrophages/metabolism
Czasopismo naukowe
Tytuł:
Synchronous profiling of mRNA N6-methyladenosine modifications and mRNA expression in high-grade serous ovarian cancer: a pilot study.
Autorzy:
Yang L; Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Liu J; Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.; The Second Clinical Medical College, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China.
Jin Y; Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Xing J; Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Zhang J; Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Chen X; Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China. .
Yu A; Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China. .; The Second Clinical Medical College, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 May 07; Vol. 14 (1), pp. 10427. Date of Electronic Publication: 2024 May 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenosine*/analogs & derivatives
Adenosine*/metabolism
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/pathology
Ovarian Neoplasms*/metabolism
RNA, Messenger*/genetics
RNA, Messenger*/metabolism
Gene Expression Regulation, Neoplastic*
Humans ; Female ; Pilot Projects ; Gene Expression Profiling ; Cystadenocarcinoma, Serous/genetics ; Cystadenocarcinoma, Serous/pathology ; Cystadenocarcinoma, Serous/metabolism ; Neoplasm Grading ; Middle Aged ; Transcriptome ; DNA Methylation
Czasopismo naukowe
Tytuł:
Circ-0075305 hinders gastric cancer stem cells by indirectly disrupting TCF4-β-catenin complex and downregulation of SOX9.
Autorzy:
Chen QY; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Xu KX; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Huang XB; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Fan DH; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Chen YJ; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Li YF; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Huang Q; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Liu ZY; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Zheng HL; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Huang ZN; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Lin ZH; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Wang YX; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Yang JJ; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Zhong Q; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China. .; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China. .; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China. .
Huang CM; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China. .; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China. .; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China. .
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Źródło:
Communications biology [Commun Biol] 2024 May 07; Vol. 7 (1), pp. 545. Date of Electronic Publication: 2024 May 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Stomach Neoplasms*/genetics
Stomach Neoplasms*/metabolism
Stomach Neoplasms*/pathology
SOX9 Transcription Factor*/metabolism
SOX9 Transcription Factor*/genetics
Neoplastic Stem Cells*/metabolism
Neoplastic Stem Cells*/pathology
beta Catenin*/metabolism
beta Catenin*/genetics
RNA, Circular*/genetics
RNA, Circular*/metabolism
Transcription Factor 4*/genetics
Transcription Factor 4*/metabolism
Down-Regulation*
Gene Expression Regulation, Neoplastic*
Humans ; Animals ; Mice ; Cell Line, Tumor ; Mice, Nude ; Male ; Female ; Drug Resistance, Neoplasm/genetics ; Mice, Inbred BALB C ; Middle Aged
Czasopismo naukowe
Tytuł:
Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma.
Autorzy:
Li F; Department of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Peking University Third Hospital, Beijing, 100191, China.
Si W; Department of Laboratory Medicine, Peking University Third Hospital, Beijing, 100191, China.
Xia L; Department of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Peking University Third Hospital, Beijing, 100191, China.
Yin D; Department of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Peking University Third Hospital, Beijing, 100191, China.
Wei T; Department of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Peking University Third Hospital, Beijing, 100191, China.
Tao M; Department of General Surgery, Peking University Third Hospital, Beijing, 100191, China.
Cui X; Department of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Peking University Third Hospital, Beijing, 100191, China.
Yang J; Department of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Peking University Third Hospital, Beijing, 100191, China.
Hong T; Department of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Peking University Third Hospital, Beijing, 100191, China. .
Wei R; Department of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Peking University Third Hospital, Beijing, 100191, China. .
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Źródło:
Molecular cancer [Mol Cancer] 2024 May 06; Vol. 23 (1), pp. 90. Date of Electronic Publication: 2024 May 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Pancreatic Ductal*/metabolism
Carcinoma, Pancreatic Ductal*/pathology
Carcinoma, Pancreatic Ductal*/genetics
Histones*/metabolism
Glycolysis*
Pancreatic Neoplasms*/metabolism
Pancreatic Neoplasms*/pathology
Pancreatic Neoplasms*/genetics
Gene Expression Regulation, Neoplastic*
L-Lactate Dehydrogenase*
Humans ; Animals ; Cell Line, Tumor ; Mice ; Feedback, Physiological ; Epigenesis, Genetic ; Carcinogenesis/metabolism ; Carcinogenesis/genetics ; Prognosis ; Cell Proliferation ; Female
Czasopismo naukowe
Tytuł:
Methyl CpG binding protein MBD2 has a regulatory role on the BRCA1 gene expression and its modulation by resveratrol in ER+, PR+ & triple-negative breast cancer cells.
Autorzy:
Sahu RK; Division of Molecular Oncology, ICMR-National Institute of Cancer Prevention and Research, I -7, Sector - 39, Noida, Uttar Pradesh, 201301, India.; Amity Institute of Molecular Medicine & Stem Cell Research, Amity University, Noida, Uttar Pradesh, 201313, India.
Tandon S; Amity University, Mohali, Punjab, 140306, India.
Singh S; Division of Clinical Oncology, ICMR-National Institute of Cancer Prevention and Research, I -7, Sector - 39, Noida, Uttar Pradesh, 201301, India.
Das BC; Amity Institute of Molecular Medicine & Stem Cell Research, Amity University, Noida, Uttar Pradesh, 201313, India.
Hedau ST; Division of Molecular Oncology, ICMR-National Institute of Cancer Prevention and Research, I -7, Sector - 39, Noida, Uttar Pradesh, 201301, India. .
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Źródło:
BMC cancer [BMC Cancer] 2024 May 06; Vol. 24 (1), pp. 566. Date of Electronic Publication: 2024 May 06.
Typ publikacji:
Journal Article
MeSH Terms:
Resveratrol*/pharmacology
Resveratrol*/therapeutic use
BRCA1 Protein*/genetics
BRCA1 Protein*/metabolism
Gene Expression Regulation, Neoplastic*/drug effects
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/genetics
Triple Negative Breast Neoplasms*/pathology
Triple Negative Breast Neoplasms*/metabolism
DNA-Binding Proteins*/metabolism
DNA-Binding Proteins*/genetics
Promoter Regions, Genetic*
Humans ; Female ; Cell Line, Tumor ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Movement/drug effects ; Receptors, Estrogen/metabolism ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use
Czasopismo naukowe
Tytuł:
Comprehensive characterization of stemness-related lncRNAs in triple-negative breast cancer identified a novel prognostic signature related to treatment outcomes, immune landscape analysis and therapeutic guidance: a silico analysis with in vivo experiments.
Autorzy:
Zhang M; Xiangya Hospital, Central South University, Changsha, 41000, Hunan, People's Republic of China.
Zhang F; Department of General Surgery, The Fourth People's Hospital of Jinan, Jinan, 250000, Shandong, People's Republic of China.
Wang J; Department of Gastrointestinal Surgery, 970 Hospital of the PLA Joint Logistic Support Force, Yantai, 264000, Shandong, People's Republic of China.
Liang Q; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Zhou W; Department of Oncology, Xiangya Hospital, Central South University, Changsha, 41000, Hunan, People's Republic of China.
Liu J; Department of Otolaryngology-Head and Neck Surgery, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, 201700, People's Republic of China. Liujian_.
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Źródło:
Journal of translational medicine [J Transl Med] 2024 May 04; Vol. 22 (1), pp. 423. Date of Electronic Publication: 2024 May 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Triple Negative Breast Neoplasms*/genetics
Triple Negative Breast Neoplasms*/pathology
Triple Negative Breast Neoplasms*/immunology
Neoplastic Stem Cells*/metabolism
Neoplastic Stem Cells*/pathology
Gene Expression Regulation, Neoplastic*
Computer Simulation*
Humans ; Prognosis ; Female ; Treatment Outcome ; Animals ; Kaplan-Meier Estimate ; Gene Regulatory Networks ; Middle Aged ; Cell Line, Tumor ; ROC Curve ; Gene Expression Profiling ; Proportional Hazards Models ; Immunity/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism
Czasopismo naukowe
Tytuł:
Integrative analyses of bulk and single-cell transcriptomics reveals the infiltration and crosstalk of cancer-associated fibroblasts as a novel predictor for prognosis and microenvironment remodeling in intrahepatic cholangiocarcinoma.
Autorzy:
Zhong YJ; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Luo XM; Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Liu F; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
He ZQ; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Yang SQ; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Ma WJ; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Wang JK; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Dai YS; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Zou RQ; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Hu YF; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Lv TR; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Li FY; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China. lfy_.
Hu HJ; Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 May 03; Vol. 22 (1), pp. 422. Date of Electronic Publication: 2024 May 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cholangiocarcinoma*/genetics
Cholangiocarcinoma*/pathology
Tumor Microenvironment*/genetics
Cancer-Associated Fibroblasts*/metabolism
Cancer-Associated Fibroblasts*/pathology
Single-Cell Analysis*
Bile Duct Neoplasms*/genetics
Bile Duct Neoplasms*/pathology
Bile Duct Neoplasms*/metabolism
Gene Expression Regulation, Neoplastic*
Humans ; Prognosis ; Transcriptome/genetics ; Gene Expression Profiling ; Gene Regulatory Networks ; Cell Communication
Czasopismo naukowe
Tytuł:
Exploring CDKN1A Upregulation Mechanisms: Insights into Cell Cycle Arrest Induced by NC2603 Curcumin Analog in MCF-7 Breast Cancer Cells.
Autorzy:
Nishimura FG; Unidade de Biotecnologia, Universidade de Ribeirão Preto (UNAERP), Ribeirao Preto 14096-900, Brazil.
Sampaio BB; Unidade de Biotecnologia, Universidade de Ribeirão Preto (UNAERP), Ribeirao Preto 14096-900, Brazil.
Komoto TT; Unidade de Biotecnologia, Universidade de Ribeirão Preto (UNAERP), Ribeirao Preto 14096-900, Brazil.
da Silva WJ; Unidade de Biotecnologia, Universidade de Ribeirão Preto (UNAERP), Ribeirao Preto 14096-900, Brazil.
da Costa MMG; Unidade de Biotecnologia, Universidade de Ribeirão Preto (UNAERP), Ribeirao Preto 14096-900, Brazil.
Haddad GI; Unidade de Biotecnologia, Universidade de Ribeirão Preto (UNAERP), Ribeirao Preto 14096-900, Brazil.
Peronni KC; Instituto para Pesquisa do Cancêr (IPEC), Guarapuava 85051-060, Brazil.
Evangelista AF; Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro 21040-900, Brazil.
Hossain M; School of Sciences, Indiana University Kokomo, Kokomo, IN 46904, USA.
Dimmock JR; College of Pharmacy and Nutrition, University of Saskatchewan (USask), Saskatoon, SK S7N 5A2, Canada.
Bandy B; College of Pharmacy and Nutrition, University of Saskatchewan (USask), Saskatoon, SK S7N 5A2, Canada.
Beleboni RO; Unidade de Biotecnologia, Universidade de Ribeirão Preto (UNAERP), Ribeirao Preto 14096-900, Brazil.
Marins M; Unidade de Biotecnologia, Universidade de Ribeirão Preto (UNAERP), Ribeirao Preto 14096-900, Brazil.
Fachin AL; Unidade de Biotecnologia, Universidade de Ribeirão Preto (UNAERP), Ribeirao Preto 14096-900, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 May 03; Vol. 25 (9). Date of Electronic Publication: 2024 May 03.
Typ publikacji:
Journal Article
MeSH Terms:
Curcumin*/pharmacology
Curcumin*/analogs & derivatives
Breast Neoplasms*/metabolism
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Breast Neoplasms*/pathology
Cyclin-Dependent Kinase Inhibitor p21*/metabolism
Cyclin-Dependent Kinase Inhibitor p21*/genetics
Cell Cycle Checkpoints*/drug effects
Gene Expression Regulation, Neoplastic*/drug effects
Humans ; MCF-7 Cells ; Female ; Up-Regulation/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/genetics ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor alpha/genetics ; Antineoplastic Agents/pharmacology ; GADD45 Proteins
Czasopismo naukowe
Tytuł:
Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to intraperitoneal paclitaxel therapy in gastric cancer patients with peritoneal metastasis.
Autorzy:
Makinoya M; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Miyatani K; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan. .
Matsumi Y; Division of Chemical Biology, Technical Department, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Sakano Y; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Shimizu S; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Shishido Y; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Hanaki T; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Kihara K; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Matsunaga T; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Yamamoto M; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Tokuyasu N; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Takano S; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Sakamoto T; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Hasegawa T; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Saito H; Department of Surgery, Japanese Red Cross Tottori Hospital, Tottori, 680‑8517, Japan.
Nakayama Y; Division of Radioisotope Science, Research Initiative Center, Organization for Research Initiative and Promotion, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Osaki M; Division of Experimental Pathology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.; Chromosomal Engineering Research Center, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Okada F; Division of Experimental Pathology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.; Chromosomal Engineering Research Center, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Fujiwara Y; Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
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Źródło:
Scientific reports [Sci Rep] 2024 May 02; Vol. 14 (1), pp. 10075. Date of Electronic Publication: 2024 May 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
MicroRNAs*/genetics
MicroRNAs*/metabolism
Stomach Neoplasms*/drug therapy
Stomach Neoplasms*/genetics
Stomach Neoplasms*/pathology
Stomach Neoplasms*/metabolism
Paclitaxel*/pharmacology
Paclitaxel*/therapeutic use
Paclitaxel*/administration & dosage
Drug Resistance, Neoplasm*/genetics
Exosomes*/metabolism
Exosomes*/genetics
Peritoneal Neoplasms*/secondary
Peritoneal Neoplasms*/drug therapy
Peritoneal Neoplasms*/genetics
Peritoneal Neoplasms*/metabolism
Mad2 Proteins*/metabolism
Mad2 Proteins*/genetics
Gene Expression Regulation, Neoplastic*/drug effects
Humans ; Cell Line, Tumor ; Male ; Female ; Middle Aged ; Aged ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Antineoplastic Agents, Phytogenic/administration & dosage
Czasopismo naukowe
Tytuł:
Patient-derived castration-resistant prostate cancer model revealed CTBP2 upregulation mediated by OCT1 and androgen receptor.
Autorzy:
Obinata D; Department of Urology, Nihon University School of Medicine, 30-1, Ooyaguchikamicho, Itabashi-ku, Tokyo, 173-8610, Japan.; Monash Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC, 3800, Australia.
Takayama K; Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Itabashi-ku Tokyo, Tokyo, 173-0015, Japan.
Lawrence MG; Monash Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC, 3800, Australia.; Cancer Research Division, Peter MacCallum Cancer Centre, 305 Grattan Street, Parkville, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, 305 Grattan Street, Parkville, VIC, 3010, Australia.; Cabrini Institute, Cabrini Health, 183 Wattletree Road, Malvern, VIC, 3144, Australia.
Funakoshi D; Department of Urology, Nihon University School of Medicine, 30-1, Ooyaguchikamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
Hara M; Division of Neurology, Department of Medicine, Nihon University School of Medicine, 30-1, Ooyaguchikamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
Niranjan B; Monash Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC, 3800, Australia.
Teng L; Monash Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC, 3800, Australia.
Taylor RA; Cancer Research Division, Peter MacCallum Cancer Centre, 305 Grattan Street, Parkville, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, 305 Grattan Street, Parkville, VIC, 3010, Australia.; Cabrini Institute, Cabrini Health, 183 Wattletree Road, Malvern, VIC, 3144, Australia.; Monash Biomedicine Discovery Institute, Department of Physiology, Monash University, Wellington Road, Clayton, VIC, 3800, Australia.
Risbridger GP; Monash Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC, 3800, Australia.; Cancer Research Division, Peter MacCallum Cancer Centre, 305 Grattan Street, Parkville, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, 305 Grattan Street, Parkville, VIC, 3010, Australia.; Cabrini Institute, Cabrini Health, 183 Wattletree Road, Malvern, VIC, 3144, Australia.
Takahashi S; Department of Urology, Nihon University School of Medicine, 30-1, Ooyaguchikamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
Inoue S; Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Itabashi-ku Tokyo, Tokyo, 173-0015, Japan. .; Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1241, Japan. .
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Źródło:
BMC cancer [BMC Cancer] 2024 May 02; Vol. 24 (1), pp. 554. Date of Electronic Publication: 2024 May 02.
Typ publikacji:
Journal Article
MeSH Terms:
Prostatic Neoplasms, Castration-Resistant*/genetics
Prostatic Neoplasms, Castration-Resistant*/pathology
Prostatic Neoplasms, Castration-Resistant*/metabolism
Receptors, Androgen*/metabolism
Receptors, Androgen*/genetics
Gene Expression Regulation, Neoplastic*
Octamer Transcription Factor-1*/metabolism
Octamer Transcription Factor-1*/genetics
Alcohol Oxidoreductases*/genetics
Alcohol Oxidoreductases*/metabolism
Co-Repressor Proteins*
Male ; Humans ; Mice ; Animals ; Up-Regulation ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; Tumor Microenvironment ; Signal Transduction
Czasopismo naukowe
Tytuł:
Elucidating immunological characteristics of the adenoma-carcinoma sequence in colorectal cancer patients in South Korea using a bioinformatics approach.
Autorzy:
Song J; Department of Life Sciences, Dongguk University, Seoul, 04620, South Korea.
Kim D; Department of Life Sciences, Dongguk University, Seoul, 04620, South Korea.
Jung J; Department of Life Sciences, Dongguk University, Seoul, 04620, South Korea.; Division of AI Software Convergence, Dongguk University-Seoul, Seoul, 04620, South Korea.; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Hollywood, CA, USA.
Choi E; Department of Life Sciences, Dongguk University, Seoul, 04620, South Korea.
Lee Y; Department of Life Sciences, Dongguk University, Seoul, 04620, South Korea.
Jeong Y; Department of Life Sciences, Dongguk University, Seoul, 04620, South Korea.
Lee B; Department of Life Sciences, Dongguk University, Seoul, 04620, South Korea.
Lee S; Department of Life Sciences, Dongguk University, Seoul, 04620, South Korea.
Shim Y; Department of Life Sciences, Dongguk University, Seoul, 04620, South Korea.
Won Y; Department of Life Sciences, Dongguk University, Seoul, 04620, South Korea.
Cho H; Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, 10326, South Korea.
Jang DK; Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, 07061, South Korea.
Kang HW; Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, 10326, South Korea. .; Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, 07061, South Korea. .
Joo JWJ; Division of AI Software Convergence, Dongguk University-Seoul, Seoul, 04620, South Korea. .
Jang W; Department of Life Sciences, Dongguk University, Seoul, 04620, South Korea. .
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Źródło:
Scientific reports [Sci Rep] 2024 May 02; Vol. 14 (1), pp. 10105. Date of Electronic Publication: 2024 May 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/immunology
Colorectal Neoplasms*/pathology
Adenoma*/genetics
Adenoma*/immunology
Adenoma*/pathology
Computational Biology*/methods
Gene Expression Regulation, Neoplastic*
Humans ; Republic of Korea ; Male ; Female ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Prognosis ; Middle Aged ; Aged ; Biomarkers, Tumor/genetics ; Kaplan-Meier Estimate ; Gene Expression Profiling
Czasopismo naukowe
Tytuł:
DDX18 Facilitates the Tumorigenesis of Lung Adenocarcinoma by Promoting Cell Cycle Progression through the Upregulation of CDK4.
Autorzy:
Feng B; Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou 510080, China.
Wang X; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou 510080, China.
Qiu D; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou 510080, China.
Sun H; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou 510080, China.
Deng J; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou 510080, China.
Tan Y; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou 510080, China.
Ji K; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou 510080, China.
Xu S; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou 510080, China.
Zhang S; Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Tang C; Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou 510080, China.; Animal Experiment Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 May 01; Vol. 25 (9). Date of Electronic Publication: 2024 May 01.
Typ publikacji:
Journal Article
MeSH Terms:
DEAD-box RNA Helicases*/metabolism
DEAD-box RNA Helicases*/genetics
Adenocarcinoma of Lung*/genetics
Adenocarcinoma of Lung*/pathology
Adenocarcinoma of Lung*/metabolism
Lung Neoplasms*/genetics
Lung Neoplasms*/metabolism
Lung Neoplasms*/pathology
Gene Expression Regulation, Neoplastic*
Cyclin-Dependent Kinase 4*/metabolism
Cyclin-Dependent Kinase 4*/genetics
Humans ; Animals ; Cell Line, Tumor ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Up-Regulation ; Mice ; Cell Cycle/genetics ; Cell Proliferation ; Mice, Nude
Czasopismo naukowe
Tytuł:
Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population.
Autorzy:
Porter T; Department of Biochemistry, Universidad Central del Caribe, Bayamón, PR 00956, USA.
Del Valle MM; Department of Surgery, Neurosurgery Section, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00921, USA.
Kucheryavykh L; Department of Biochemistry, Universidad Central del Caribe, Bayamón, PR 00956, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 May 01; Vol. 25 (9). Date of Electronic Publication: 2024 May 01.
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/ethnology
Hispanic or Latino*/genetics
Signal Transduction*/genetics
Gene Expression Regulation, Neoplastic*
Brain Neoplasms*/genetics
Brain Neoplasms*/ethnology
Humans ; Male ; Female ; Puerto Rico ; Focal Adhesion Protein-Tyrosine Kinases/genetics ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Middle Aged ; ErbB Receptors/genetics ; Adult ; Aged
Czasopismo naukowe
Tytuł:
Long non-coding RNA NEAT1 promotes aerobic glycolysis and progression of cervical cancer through WNT/β-catenin/PDK1 axis.
Autorzy:
Su M; Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, People's Republic of China.; Hubei Cancer Clinical Study Center, Wuhan, People's Republic of China.
Liang Z; Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, People's Republic of China.; Hubei Cancer Clinical Study Center, Wuhan, People's Republic of China.
Shan S; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, People's Republic of China.; Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.
Gao Y; Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, People's Republic of China.; Hubei Cancer Clinical Study Center, Wuhan, People's Republic of China.
He L; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, People's Republic of China.; Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.
Liu X; Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, People's Republic of China.; Hubei Cancer Clinical Study Center, Wuhan, People's Republic of China.
Wang A; Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, People's Republic of China.; Hubei Cancer Clinical Study Center, Wuhan, People's Republic of China.
Wang H; Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, People's Republic of China.; Hubei Cancer Clinical Study Center, Wuhan, People's Republic of China.
Cai H; Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, People's Republic of China.; Hubei Cancer Clinical Study Center, Wuhan, People's Republic of China.
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Źródło:
Cancer medicine [Cancer Med] 2024 May; Vol. 13 (9), pp. e7221.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Uterine Cervical Neoplasms*/genetics
Uterine Cervical Neoplasms*/pathology
Uterine Cervical Neoplasms*/metabolism
Pyruvate Dehydrogenase Acetyl-Transferring Kinase*/metabolism
Pyruvate Dehydrogenase Acetyl-Transferring Kinase*/genetics
Wnt Signaling Pathway*
Disease Progression*
Cell Proliferation*
Gene Expression Regulation, Neoplastic*
Humans ; Female ; Cell Line, Tumor ; beta Catenin/metabolism ; beta Catenin/genetics ; Glycolysis ; Cell Movement
Czasopismo naukowe
Tytuł:
E2F transcription factors promote tumorigenicity in pancreatic ductal adenocarcinoma.
Autorzy:
Bertonnier-Brouty L; Lund Stem Cell Center, Lund University, Lund, Sweden.; Lund University Diabetes Center, Lund University, Malmö, Sweden.
Andersson J; Lund University Diabetes Center, Lund University, Malmö, Sweden.
Kaprio T; Department of Surgery, Helsinki University Hospital, Helsinki, Finland.; Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN, Digital Cancer Precision Medicine, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.
Hagström J; Department of Surgery, Helsinki University Hospital, Helsinki, Finland.; Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN, Digital Cancer Precision Medicine, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.; Department of Oral Pathology and Radiology, University of Turku, Turku, Finland.
Bsharat S; Lund Stem Cell Center, Lund University, Lund, Sweden.; Lund University Diabetes Center, Lund University, Malmö, Sweden.
Asplund O; Lund University Diabetes Center, Lund University, Malmö, Sweden.
Hatem G; Lund University Diabetes Center, Lund University, Malmö, Sweden.
Haglund C; Department of Surgery, Helsinki University Hospital, Helsinki, Finland.; Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN, Digital Cancer Precision Medicine, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.
Seppänen H; Department of Surgery, Helsinki University Hospital, Helsinki, Finland.; Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN, Digital Cancer Precision Medicine, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.
Prasad RB; Lund University Diabetes Center, Lund University, Malmö, Sweden.
Artner I; Lund Stem Cell Center, Lund University, Lund, Sweden.; Lund University Diabetes Center, Lund University, Malmö, Sweden.
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Źródło:
Cancer medicine [Cancer Med] 2024 May; Vol. 13 (9), pp. e7187.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Pancreatic Ductal*/genetics
Carcinoma, Pancreatic Ductal*/pathology
Carcinoma, Pancreatic Ductal*/metabolism
Pancreatic Neoplasms*/genetics
Pancreatic Neoplasms*/pathology
Pancreatic Neoplasms*/metabolism
Cell Proliferation*
E2F1 Transcription Factor*/metabolism
E2F1 Transcription Factor*/genetics
Cell Movement*/genetics
Apoptosis*
Gene Expression Regulation, Neoplastic*
Humans ; Cell Line, Tumor ; Animals ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Cell Survival/genetics ; Mice
Czasopismo naukowe
Tytuł:
NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2.
Autorzy:
Cardenas RP; SVMS, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK.
Zyoud A; SVMS, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK.
McIntyre A; School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, UK.; Centre for Cancer Sciences and Nottingham Breast Cancer Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, UK.
Alberio R; School of Biosciences, Faculty of Science, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK.
Mongan NP; SVMS, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK.; Centre for Cancer Sciences and Nottingham Breast Cancer Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, UK.; Department of Pharmacology, Weill Cornell Medicine, 1300 York Avenue, New York, NY, 10065, USA.
Allegrucci C; SVMS, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK. .; Centre for Cancer Sciences and Nottingham Breast Cancer Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, UK. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2024 May 01; Vol. 15 (1), pp. 128. Date of Electronic Publication: 2024 May 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nanog Homeobox Protein*/metabolism
Nanog Homeobox Protein*/genetics
MicroRNAs*/genetics
MicroRNAs*/metabolism
Neoplasms, Germ Cell and Embryonal*/genetics
Neoplasms, Germ Cell and Embryonal*/metabolism
Neoplasms, Germ Cell and Embryonal*/pathology
Testicular Neoplasms*/pathology
Testicular Neoplasms*/metabolism
Testicular Neoplasms*/genetics
Gene Expression Regulation, Neoplastic*
Humans ; Male ; Cell Line, Tumor ; Cell Proliferation/genetics ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Cisplatin/pharmacology
SCR Disease Name:
Testicular Germ Cell Tumor
Czasopismo naukowe
Tytuł:
Ethanol responsive lnc171 promotes migration and invasion of HCC cells via mir-873-5p/ZEB1 axis.
Autorzy:
Huang S; School of Public Health, Guangxi Medical University, Nanning, 530021, China.
Liao Z; School of Public Health, Guangxi Medical University, Nanning, 530021, China.
He X; School of Public Health, Guilin Medical School, Guilin, 541199, China.
Song Z; School of Public Health, Guangxi Medical University, Nanning, 530021, China.
Fang X; Laboratory Animal Center of Guangxi Medical University, Nanning, 530021, China.
Wen S; School of Public Health, Guangxi Medical University, Nanning, 530021, China.; Laboratory Animal Center of Guangxi Medical University, Nanning, 530021, China.
Yang L; Laboratory Animal Center of Guangxi Medical University, Nanning, 530021, China.
Li H; School of Public Health, Guangxi Medical University, Nanning, 530021, China.
Zhang Q; Laboratory Animal Center of Guangxi Medical University, Nanning, 530021, China.
Mo W; School of Public Health, Guangxi Medical University, Nanning, 530021, China.
Cheng X; School of Public Health, Guangxi Medical University, Nanning, 530021, China.; Life Sciences Institute of Guangxi Medical University, Nanning, 530021, China.
He M; School of Public Health, Guangxi Medical University, Nanning, 530021, China. .; Laboratory Animal Center of Guangxi Medical University, Nanning, 530021, China. .; Key Laboratory of High-Incidence-Tumor Prevention & Treatment, Guangxi Medical University, Ministry of Education, Nanning, 530021, China. .
Huang X; Laboratory Animal Center of Guangxi Medical University, Nanning, 530021, China. .
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Źródło:
BMC cancer [BMC Cancer] 2024 May 01; Vol. 24 (1), pp. 550. Date of Electronic Publication: 2024 May 01.
Typ publikacji:
Journal Article
MeSH Terms:
MicroRNAs*/genetics
RNA, Long Noncoding*/genetics
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/pathology
Carcinoma, Hepatocellular*/metabolism
Liver Neoplasms*/genetics
Liver Neoplasms*/pathology
Liver Neoplasms*/metabolism
Zinc Finger E-box-Binding Homeobox 1*/genetics
Zinc Finger E-box-Binding Homeobox 1*/metabolism
Cell Movement*/genetics
Ethanol*/pharmacology
Gene Expression Regulation, Neoplastic*
Humans ; Cell Line, Tumor ; Neoplasm Invasiveness/genetics
Czasopismo naukowe
Tytuł:
Pan-cancer analysis reveals correlation between RAB3B expression and tumor heterogeneity, immune microenvironment, and prognosis in multiple cancers.
Autorzy:
Liu XS; Department of Nuclear Medicine, Hubei Provincial Clinical Research Center for Precision Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Hubei, 442000, China.; Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China.; Hubei Key Laboratory of Embryonic Stem Cell Research, Shiyan, 442000, Hubei, China.
Chen YL; Department of Gastroenterology, The Affiliated Hospital of Hebei University, Baoding, 071000, Hebei, China.
Chen YX; Department of Nuclear Medicine, Hubei Provincial Clinical Research Center for Precision Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Hubei, 442000, China.
Wu RM; Department of Nuclear Medicine, Hubei Provincial Clinical Research Center for Precision Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Hubei, 442000, China.
Tan F; Department of Nuclear Medicine, Hubei Provincial Clinical Research Center for Precision Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Hubei, 442000, China.
Wang YL; Department of Nuclear Medicine, Hubei Provincial Clinical Research Center for Precision Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Hubei, 442000, China.
Liu ZY; Department of Nuclear Medicine, Hubei Provincial Clinical Research Center for Precision Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Hubei, 442000, China.
Gao Y; Department of Nuclear Medicine, Hubei Provincial Clinical Research Center for Precision Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Hubei, 442000, China.
Pei ZJ; Department of Nuclear Medicine, Hubei Provincial Clinical Research Center for Precision Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Hubei, 442000, China. .; Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China. .; Hubei Key Laboratory of Embryonic Stem Cell Research, Shiyan, 442000, Hubei, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Apr 30; Vol. 14 (1), pp. 9881. Date of Electronic Publication: 2024 Apr 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers, Tumor*/genetics
DNA Methylation*
Gene Expression Regulation, Neoplastic*
Neoplasms*/genetics
Neoplasms*/immunology
Neoplasms*/diagnosis
Neoplasms*/pathology
rab3 GTP-Binding Proteins*/genetics
rab3 GTP-Binding Proteins*/metabolism
Tumor Microenvironment*/immunology
Tumor Microenvironment*/genetics
Humans ; Computational Biology/methods ; Mutation ; Prognosis
Czasopismo naukowe

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