Temat: "Gene Expression Regulation drug effects" - OpacWWW - Prolib Integro

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Tytuł :: Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with chronic mountain sickness
Autorzy :: Bermudez, Daniela
Azad, Priti
Figueroa-Mujíca, Rómulo
Vizcardo-Galindo, Gustavo
Corante, Noemí
Guerra-Giraldez, Cristina
Haddad, Gabriel G.
Villafuerte, Francisco C.; Pokaż więcej
Temat :: Research Article
Andean
chronic mountain sickness
erythropoiesis
excessive erythrocytosis
high altitude
Physiology (medical)
Physiology
Effects of high altitude on humans
Erythroid Progenitor Cells
Erythropoiesis
Medicine
business.industry
business
Chronic mountain sickness
medicine.disease
Gene expression
Proliferative response
Clinical syndrome
Immunology
Humans
Chronic Disease
Genetic Predisposition to Disease
Altitude
Altitude Sickness/epidemiology
Erythroid Precursor Cells/metabolism
Erythropoietin/blood
Gene Expression Regulation/drug effects
Homeostasis
Hypoxia
Iron/metabolism
Leukocytes, Mononuclear
Oxygen/metabolism/pharmacology
Transcriptome
purl.org/pe-repo/ocde/ford#3.02.00 [https]
purl.org/pe-repo/ocde/ford#3.01.08 [https]
health care economics and organizations
Źródło :: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Crossref
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4286be60c0f035a9dd55c684bda53dab
http://europepmc.org/articles/PMC6985794

Szczegóły

Skocz do pozycji: 2 2.

Podgląd okładki

Tytuł :: Rare and common genetic variations in the Keap1/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively
Autorzy :: Matana, Antonela
Ziros, Panos G.
Chartoumpekis, Dionysios V.
Renaud, Cedric O.
Polašek, Ozren
Hayward, Caroline
Zemunik, Tatijana
Sykiotis, Gerasimos P.; Pokaż więcej
Temat :: Animals
Antioxidant Response Elements/genetics
Antioxidants/pharmacology
Cell Line
Gene Expression Regulation/drug effects
Genome-Wide Association Study
Humans
Isothiocyanates/pharmacology
Kelch-Like ECH-Associated Protein 1/genetics
Kelch-Like ECH-Associated Protein 1/metabolism
NF-E2-Related Factor 2/genetics
NF-E2-Related Factor 2/metabolism
Polymorphism, Single Nucleotide
Rats
Signal Transduction/drug effects
Signal Transduction/genetics
Thyroglobulin/blood
Thyroglobulin/genetics
Thyroglobulin/metabolism
Thyroid Gland/drug effects
Thyroid Gland/metabolism
Thyrotropin/pharmacology
Keap1
Nrf2
SNP
Thyroglobulin
Thyroid
Pharmacology
Biochemistry
Cancer research
Single-nucleotide polymorphism
Gene expression
Genome-wide association study
Enhancer
Biology
Antioxidant Response Elements
medicine.medical_treatment
medicine
Transcription factor
Population
education.field_of_study
education
Źródło :: Biochemical pharmacology, vol. 173, pp. 113605
Matana, A, Ziros, P G, Chartoumpekis, D V, Renaud, C O, Polašek, O, Hayward, C, Zemunik, T & Sykiotis, G P 2019, ' Rare and common genetic variations in the Keap1/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively ', Biochemical Pharmacology . https://doi.org/10.1016/j.bcp.2019.08.007
Crossref
Opis pliku :: application/pdf
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32432a045b57211f0f1a429ccce1cbdc
https://serval.unil.ch/notice/serval:BIB_4E02568FE6AA

Szczegóły

Skocz do pozycji: 3 3.

Podgląd okładki

Tytuł :: Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes
Autorzy :: Daniel Lopatta
Alexander Lukas
Danyel G. J. Jennen
Gökhan Ertaylan
Tobias Stumm
Rachel Cavill
Evgueni Smirnov
Ralf Peeters
Natal A.W. van Riel
Jelmer Neeven
Shauna D O'Donovan
Michael Lenz
Theo M.C.M. de Kok
Kurt Driessens
Florian Wimmenauer; Pokaż więcej
Temat :: Algorithms
Animals
Clinical Trials as Topic/statistics & numerical data
Deep Learning
Gene Expression Regulation/drug effects
Hepatocytes/drug effects
Humans
Machine Learning
Neural Networks, Computer
Rats
Multidisciplinary
Artificial neural network
In vivo
Convolutional neural network
Deep learning
Computational biology
Artificial intelligence
business.industry
business
Bioassay
Biology
Gene
Toxicogenomics
Gene expression
Medicine
Science
Chair Nutrition Metabolism and Genomics
HNE Voeding, Metabolisme en Genomics
Voeding, Metabolisme en Genomica
HNE Nutrition, Metabolism and Genomics
Nutrition, Metabolism and Genomics
REPRESENTATIONS
TOXICOGENOMICS
TOXICOLOGY
TOXICITY
HNE Voeding
Metabolisme en Genomics
Voeding
Metabolisme en Genomica
HNE Nutrition
Metabolism and Genomics
Nutrition
Neural Networks
Computer
Research Article
Biology and Life Sciences
Genetics
Gene Expression
Predictive Toxicology
Medicine and Health Sciences
Pathology and Laboratory Medicine
Pharmaceutics
Dose Prediction Methods
Computer and Information Sciences
Artificial Intelligence
Genetic Toxicology
Neuroscience
Engineering and Technology
Measurement
Time Measurement
Źródło :: PLoS ONE, 15(8). Public Library of Science
Crossref
PLoS ONE, Vol 15, Iss 8, p e0236392 (2020)
PLoS ONE, 15(8)
PLOS ONE, 15(8):e0236392. Public Library of Science
PLoS ONE, 15(8):e0236392. Public Library of Science
PLoS ONE
Opis pliku :: application/pdf
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab28b049df1eb0bf4886171aacfd7cb
https://pure.amc.nl/en/publications/use-of-deep-learning-methods-to-translate-druginduced-gene-expression-changes-from-rat-to-human-primary-hepatocytes(73c11227-9451-40b5-a199-15f21993acf5).html

Szczegóły

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Podgląd okładki

Tytuł :: The in vivo endothelial cell translatome is highly heterogeneous across vascular beds
Autorzy :: Audrey C. A. Cleuren
William C. Aird
Martijn A. van der Ent
David R. Siemieniak
David Ginsburg
Andrew J. Yee
Hui Jiang
Kristina L. Hunker
Grietje Molema
Santhi K. Ganesh; Pokaż więcej
Temat :: Biological Sciences
In vivo
Sequence analysis
Biology
Cell sorting
Endothelial stem cell
Gene
Cell
medicine.anatomical_structure
medicine
Gene expression
RNA
Cell biology
Animals
Blood Platelets/metabolism
Brain/blood supply
Endothelial Cells/metabolism
Gene Expression Regulation/drug effects
High-Throughput Nucleotide Sequencing
Lipopolysaccharides/pharmacology
Male
Mice
Mice, Inbred C57BL
Organ Specificity
Protein Biosynthesis
Protein Isoforms/metabolism
RNA, Messenger/metabolism
RNA-Binding Proteins/metabolism
Ribosomal Proteins/metabolism
Ribosomes/metabolism
Sensitivity and Specificity
Single-Cell Analysis
Transgenes
Viscera/blood supply
Inbred C57BL
Messenger/metabolism
Multidisciplinary
Ribosome
In vitro
Źródło :: Proc Natl Acad Sci U S A
Crossref
Proceedings of the National Academy of Sciences of the United States of America, 116(47), 23618-23624. NATL ACAD SCIENCES
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3844edf4e9540fe28c17ded36731085
https://europepmc.org/articles/PMC6876253/

Szczegóły

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Podgląd okładki

Tytuł :: Inflammation leads to distinct populations of extracellular vesicles from microglia
Autorzy :: Yang, Yiyi
Boza-Serrano, Antonio
Dunning, Christopher J. R.
Clausen, Bettina Hjelm
Lambertsen, Kate Lykke
Deierborg, Tomas; Pokaż więcej
Temat :: Microglia
Extracellular vesicles (EVs)
Neuroinflammation
TNF
lcsh:Neurology. Diseases of the nervous system
lcsh:RC346-429
Research
Cellular and Molecular Neuroscience
Neurology
Immunology
General Neuroscience
Tumor necrosis factor alpha
Western blot
medicine.diagnostic_test
medicine
Interleukin
Lipopolysaccharide
chemistry.chemical_compound
chemistry
medicine.anatomical_structure
Cytokine
medicine.medical_treatment
Inflammation
medicine.symptom
Cell biology
Microglia/drug effects
Protein Transport/drug effects
Nitric Oxide Synthase Type II/metabolism
Tumor Necrosis Factor-alpha/deficiency
Etanercept/pharmacology
Mice, Inbred C57BL
Infarction, Middle Cerebral Artery/complications
Male
Lipopolysaccharides/pharmacology
Signal Transduction/drug effects
Mice, Knockout
Animals
Inflammation/etiology
Immunosuppressive Agents/pharmacology
Mice
Cytokines/metabolism
Extracellular Vesicles/pathology
Cell Line, Transformed
Gene Expression Regulation/drug effects
Disease Models, Animal
Źródło :: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-19 (2018)
Journal of Neuroinflammation
Crossref
Yang, Y, Boza-Serrano, A, Dunning, C J R, Clausen, B H, Lambertsen, K L & Deierborg, T 2018, ' Inflammation leads to distinct populations of extracellular vesicles from microglia ', Journal of Neuroinflammation, vol. 15, 168 . https://doi.org/10.1186/s12974-018-1204-7
Opis pliku :: application/pdf
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5b9f02a66c45696b513383261ae0bf
http://link.springer.com/article/10.1186/s12974-018-1204-7

Szczegóły

Skocz do pozycji: 6 6.

Podgląd okładki

Tytuł :: * Fabrication and Characterization of Biphasic Silk Fibroin Scaffolds for Tendon/Ligament-to-Bone Tissue Engineering
Autorzy :: Font Tellado, Sònia
Bonani, Walter
Balmayor, Elizabeth R.
Foehr, Peter
Motta, Antonella
Migliaresi, Claudio
van Griensven, Martijn; Pokaż więcej
Temat :: Anisotropy
Biomechanical Phenomena
Bone and Bones/drug effects
Cell Death/drug effects
Cell Proliferation/drug effects
Cell Shape/drug effects
Cell Survival/drug effects
Fibroins/pharmacology
Gene Expression Regulation/drug effects
Humans
Ligaments/drug effects
Mesenchymal Stem Cells/cytology
Porosity
Tendons/drug effects
Tissue Engineering/methods
Tissue Scaffolds/chemistry
Biomedical Engineering
Biomaterials
Biochemistry
Bioengineering
Enthesis
Tendon
medicine.anatomical_structure
medicine
Extracellular matrix
Regeneration (biology)
Tissue engineering
Materials science
Fibroin
Biomedical engineering
Mesenchymal stem cell
Ligament
musculoskeletal system
Źródło :: Tissue Engineering, 23(15-16), 859-872. Mary Ann Liebert Inc.
Crossref
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5a7d0d04fdeeb7a61e8e454994b0aa

Szczegóły

Skocz do pozycji: 7 7.

Podgląd okładki

Tytuł :: Downregulation of PPARα during Experimental Left Ventricular Hypertrophy is Critically Dependent on Nox2 NADPH Oxidase Signalling
Autorzy :: Philip D. Dunne
David J. Grieve
Kevin Edgar
Ross McMullan
Karla O'Neill
Matthew Alderdice
Barbara McDermott
Adam Harvey
Raheleh Amirkhah
Emma Robinson; Pokaż więcej
Temat :: Inorganic Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Catalysis
Heart failure
medicine.disease
medicine
Muscle hypertrophy
Transcriptome
NADPH oxidase
biology.protein
biology
Oxidative stress
medicine.disease_cause
Endocrinology
medicine.medical_specialty
Left ventricular hypertrophy
Downregulation and upregulation
Regulator
Internal medicine
Chemistry
Animals
Cell Line
Disease Models, Animal
Gene Expression Regulation/drug effects
Hypertrophy, Left Ventricular/etiology
Male
Mice
Myocytes, Cardiac/cytology
NADPH Oxidase 2/genetics
Oxidative Stress
PPAR alpha/genetics
Phenylephrine/pharmacology
Rats
Signal Transduction
Nox2 NADPH oxidase
PPARα
left ventricular hypertrophy
oxidative stress
microarray
transverse aortic constriction
lcsh:Biology (General)
lcsh:QH301-705.5
lcsh:Chemistry
lcsh:QD1-999
Article
chronic heart failure
cardiovascular diseases
Źródło :: Crossref
Harvey, A P, Robinson, E, Edgar, K S, McMullan, R, O'Neill, K M, Alderdice, M, Amirkhah, R, Dunne, P D, McDermott, B J & Grieve, D J 2020, ' Downregulation of PPARα during Experimental Left Ventricular Hypertrophy Is Critically Dependent on Nox2 NADPH Oxidase Signalling ', International journal of molecular sciences, vol. 21, no. 12 . https://doi.org/10.3390/ijms21124406
International Journal of Molecular Sciences, Vol 21, Iss 4406, p 4406 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 12
Opis pliku :: application/pdf
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417eb1a2c47cf45ab1f1c1683b01ace2
https://www.mdpi.com/1422-0067/21/12/4406/pdf

Szczegóły

Skocz do pozycji: 8 8.

Podgląd okładki

Tytuł :: BMP2 and TGF-β Cooperate Differently during Synovial-Derived Stem-Cell Chondrogenesis in a Dexamethasone-Dependent Manner
Autorzy :: Kovermann, Nikolas
Basoli, Valentina
Della Bella, Elena
Alini, Mauro
Lischer, Christoph
Schmal, Hagen
Kubosch, Eva
Stoddart, Martin; Pokaż więcej
Temat :: synovial derived stromal cell
BMP-2
TGF-β
dexamethasone
chondrogenesis
Article
Adult
Bone Morphogenetic Protein 2/pharmacology
Chondrogenesis/drug effects
Collagen Type II/metabolism
DNA/metabolism
Dexamethasone/pharmacology
Gene Expression Regulation/drug effects
Glycosaminoglycans/metabolism
Humans
Male
Middle Aged
Stem Cells/cytology
Synovial Membrane/cytology
Transforming Growth Factor beta1/pharmacology
Young Adult
General Medicine
Cell
medicine.anatomical_structure
medicine
Glycosaminoglycan
Cell biology
Bone morphogenetic protein 2
Chemistry
Stem cell
Chondrogenesis
Cartilage
Mesenchymal stem cell
Regeneration (biology)
lcsh:Biology (General)
lcsh:QH301-705.5
Źródło :: Cells
Volume 8
Issue 6
Kovermann, N J, Basoli, V, Della Bella, E, Alini, M, Lischer, C, Schmal, H, Kubosch, E J & Stoddart, M J 2019, ' BMP2 and TGF-β Cooperate Differently during Synovial-Derived Stem-Cell Chondrogenesis in a Dexamethasone-Dependent Manner ', Cells, vol. 8, no. 6, 636 . https://doi.org/10.3390/cells8060636
Crossref
Cells, Vol 8, Iss 6, p 636 (2019)
Opis pliku :: application/pdf
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7438fc51a088aa63945b0ef596fe45cb

Szczegóły

Skocz do pozycji: 9 9.

Podgląd okładki

Tytuł :: Investigation of the role of GBF1 in the replication of positive-sense single-stranded RNA viruses
Autorzy :: Yves Rouillé
Rayan Farhat
Didier Hober
Jean Dubuisson
Sandrine Belouzard
Laurence Cocquerel
Juliette Ferlin
Antoine Bertin; Pokaż więcej
Temat :: hepatitis C virus
coxsackievirus B4
human coronavirus
ADP-ribosylation factor
Animals
Brefeldin A
Gene Knockdown Techniques
Guanine Nucleotide Exchange Factors/genetics
Guanine Nucleotide Exchange Factors/metabolism
Humans
Mice
Pyridines/pharmacology
Quinolines/pharmacology
RNA Interference
RNA Viruses/physiology
Virus Replication/physiology
Cell Line
Cell Survival
Gene Expression Regulation/drug effects
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
MESH: Animals
MESH: Brefeldin A
MESH: Gene Knockdown Techniques
MESH: Guanine Nucleotide Exchange Factors/genetics
MESH: Guanine Nucleotide Exchange Factors/metabolism
MESH: Humans
MESH: Mice
MESH: Pyridines/pharmacology
MESH: Quinolines/pharmacology
MESH: RNA Interference
MESH: RNA Viruses/physiology
MESH: Virus Replication/physiology
MESH: Cell Line
MESH: Cell Survival
MESH: Gene Expression Regulation/drug effects
Virology
Human coronavirus 229E
biology.organism_classification
biology
RNA
Sindbis virus
Virus
Viral replication
Host factor
Hepatitis C virus
medicine.disease_cause
medicine
Coxsackievirus
viruses
Źródło :: Journal of General Virology
Journal of General Virology, Microbiology Society, 2018, 99 (8), pp.1086-1096. ⟨10.1099/jgv.0.001099⟩
Crossref
Opis pliku :: application/octet-stream
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f61a159d161901a3885c57f1e24dc7b
http://hdl.handle.net/20.500.12210/28779

Szczegóły

Skocz do pozycji: 10 10.

Podgląd okładki

Tytuł :: Doxazosin and Carvedilol Treatment Improves Hepatic Regeneration in a Hamster Model of Cirrhosis
Autorzy :: Serna-Salas, Sandra Alejandra
Navarro-González, Yesenia Danyeli
Martínez-Hernández, Sandra Luz
Barba-Gallardo, Luis Fernando
Sánchez-Alemán, Esperanza
Aldaba-Muruato, Liseth Rubí
Macías-Pérez, José Roberto
Ventura-Juárez, Javier
Muñoz-Ortega, Martin Humberto; Pokaż więcej
Temat :: General Immunology and Microbiology
General Biochemistry, Genetics and Molecular Biology
General Medicine
Hamster
Sirius Red
chemistry.chemical_compound
chemistry
Medicine
business.industry
business
Carvedilol
medicine.drug
Cirrhosis
medicine.disease
Liver regeneration
Internal medicine
medicine.medical_specialty
Fibrosis
Endocrinology
Doxazosin
Hepatic stellate cell
Article Subject
lcsh:Medicine
lcsh:R
Animals
Antigens
Differentiation/biosynthesis
Carvedilol/pharmacology
Cell Proliferation/drug effects
Cricetinae
Disease Models
Animal
Doxazosin/pharmacology
Gene Expression Regulation/drug effects
Liver Cirrhosis/drug therapy
Liver Regeneration/drug effects
Male
Mesocricetus
Antigens, Differentiation/biosynthesis
Disease Models, Animal
Research Article
Źródło :: Crossref
BioMed Research International, Vol 2018 (2018)
BioMed Research International, 2018. HINDAWI LTD
BioMed Research International
Opis pliku :: text/xhtml
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd2d3f3d2047d2532163f21e9ec8d3d

Szczegóły

Skocz do pozycji: 11 11.

Podgląd okładki

Tytuł :: MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Autorzy :: Deraredj Nadim, Wissem
Viorel, Simion
Bénédetti, Hélène
Pichon, Chantal
Baril, Patrick
Morisset-Lopez, Séverine; Pokaż więcej
Temat :: Article
Cognitive dysfunction
LTP
MicroRNA
neurodegenerative diseases
psychiatric disorders
signaling pathways
Signal Transduction/drug effects
Neuronal Plasticity/drug effects
Neurodegenerative Diseases/drug therapy
MicroRNAs/antagonists & inhibitors/genetics/*metabolism
Humans
Gene Expression Regulation/*drug effects/physiology
Bibliographic/statistics & numerical data
Databases
Cognition Disorders/*drug therapy/genetics
Animals
Antagomirs/pharmacology/*therapeutic use
[SDV]Life Sciences [q-bio]
Pharmacology (medical)
Psychiatry and Mental health
Clinical Neurology
Neurology
Pharmacology
General Medicine
Neurogenesis
Cognition
Neurocognitive
Neuroscience
Synaptic plasticity
Autism
medicine.disease
medicine
microRNA
Disease
Schizophrenia
Biology
Źródło :: Current Neuropharmacology
Current Neuropharmacology, Bentham Science Publishers, 2017, 15 (2), pp.260-275. ⟨10.2174/1570159X14666160709001441⟩
Crossref
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266074b2d92f2322e1516a416c0ce2cf
http://europepmc.org/articles/PMC5412695

Szczegóły

Skocz do pozycji: 12 12.

Podgląd okładki

Tytuł :: The impact of interferon-alpha2 on HLA genes in patients with polycythemia vera and related neoplasms
Autorzy :: Hans Carl Hasselbalch
Mads Thomassen
Thomas Stauffer Larsen
Lasse Kjær
Ole Weis Bjerrum
Vibe Skov
Torben A Kruse
Caroline Hasselbalch Riley; Pokaż więcej
Temat :: Cancer Research
Oncology
Hematology
Somatic evolution in cancer
Cytotoxic T cell
Polycythemia vera
medicine.disease
medicine
Biology
Downregulation and upregulation
Interferon
medicine.drug
Gene expression profiling
Human leukocyte antigen
Immune system
Immunology
HLA genes
Interferon-alpha2
myeloproliferative neoplasms
tumor immune surveillance
whole blood transcriptional profiling
Interferon-alpha/pharmacology
Humans
Polycythemia Vera/drug therapy
Gene Expression Profiling
HLA Antigens/genetics
Primary Myelofibrosis/drug therapy
Thrombocythemia, Essential/drug therapy
Myeloproliferative Disorders/drug therapy
Alleles
Gene Expression Regulation/drug effects
Źródło :: Crossref
Skov, V, Riley, C H, Thomassen, M, Kjær, L, Stauffer Larsen, T, Bjerrum, O W, Kruse, T A & Hasselbalch, H C 2017, ' The impact of interferon-alpha2 on HLA genes in patients with polycythemia vera and related neoplasms ', Leukemia and Lymphoma, vol. 58, no. 8, pp. 1914-1921 . https://doi.org/10.1080/10428194.2016.1262032
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72a82c232340fc5228657b971725ba0
https://www.tandfonline.com/doi/pdf/10.1080/10428194.2016.1262032

Szczegóły

Skocz do pozycji: 13 13.

Podgląd okładki

Tytuł :: Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free 'GeneSwitch' vector
Autorzy :: Sebastian Kügler
Catherine Pythoud
Anupam Raina
Nicole Déglon
Shi Cheng
Maria Rey
Mathias Bähr
Julia Tereshchenko
Virginie Zimmer
Frank Streit
Gabriel Vachey
Andrzej Mazur
Pavlina Konstantinova
Jolanda M. Liefhebber; Pokaż więcej
Temat :: 3,4-Dihydroxyphenylacetic Acid/metabolism
Adrenergic Agents/toxicity
Animals
Disease Models, Animal
Gene Expression Regulation/drug effects
Gene Expression Regulation/genetics
Glial Cell Line-Derived Neurotrophic Factor/genetics
Glial Cell Line-Derived Neurotrophic Factor/metabolism
Green Fluorescent Proteins/genetics
Green Fluorescent Proteins/metabolism
Homovanillic Acid/metabolism
Hormone Antagonists/therapeutic use
Huntingtin Protein/genetics
Huntingtin Protein/metabolism
Huntington Disease/genetics
Huntington Disease/metabolism
Huntington Disease/pathology
Huntington Disease/therapy
Mice
Mice, Transgenic
Mifepristone/therapeutic use
Oxidopamine/toxicity
Parkinson Disease/etiology
Parkinson Disease/genetics
Parkinson Disease/metabolism
Parkinson Disease/therapy
Synapsins/genetics
Synapsins/metabolism
Synucleins/genetics
Synucleins/metabolism
Transduction, Genetic
AAV
GDNF
GeneSwitch
Huntington's disease
Mifepristone
Parkinson's disease
Regulated expression
Developmental Neuroscience
Neurology
Transduction (genetics)
medicine.disease
medicine
Transgene
Gene product
Glial cell line-derived neurotrophic factor
biology.protein
biology
Genetic enhancement
business.industry
business
Cancer research
Neurotrophic factors
Źródło :: Experimental neurology, vol. 309, pp. 79-90
Crossref
Opis pliku :: application/pdf
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6bc910cb868b3ba3bfa0229d4aa882
https://serval.unil.ch/notice/serval:BIB_74113391BE61

Szczegóły

Skocz do pozycji: 14 14.

Podgląd okładki

Tytuł :: Activation of Bone Marrow-Derived Cells Angiotensin (Ang) II Type 1 Receptor by Ang II Promotes Atherosclerotic Plaque Vulnerability
Autorzy :: Pellegrin, Maxime
Bouzourène, Karima
Aubert, Jean-François
Nahimana, Aimable
Duchosal, Michel
Mazzolai, Lucia; Pokaż więcej
Temat :: atherosclerosis
vulnerable plaque
Angiotensin II
inflammation
2-kidney, 1-clip ApoE−/− mice
bone marrow transplantation
lcsh:Biology (General)
lcsh:QH301-705.5
lcsh:Chemistry
lcsh:QD1-999
Inorganic Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Catalysis
T cell
medicine.anatomical_structure
medicine
Bone marrow
M2 Macrophage
Receptor
Endocrinology
medicine.medical_specialty
Renin–angiotensin system
Chemistry
Internal medicine
Inflammation
medicine.symptom
Vulnerable plaque
medicine.disease_cause
Angiotensins/adverse effects
Animals
Apolipoproteins E/genetics
Bone Marrow Cells/cytology
Bone Marrow Cells/drug effects
Bone Marrow Transplantation
Cytokines/genetics
Disease Models, Animal
Gene Expression Regulation/drug effects
Gene Knockdown Techniques
Humans
Lipid Metabolism
Liver/drug effects
Liver/metabolism
Mice
Plaque, Atherosclerotic/chemically induced
Plaque, Atherosclerotic/genetics
Plaque, Atherosclerotic/immunology
Receptor, Angiotensin, Type 1/genetics
Article
cardiovascular system
hormones, hormone substitutes, and hormone antagonists
Źródło :: International Journal of Molecular Sciences, Vol 19, Iss 9, p 2621 (2018)
Crossref
International journal of molecular sciences, vol. 19, no. 9, pp. E2621
International Journal of Molecular Sciences
Volume 19
Issue 9
Opis pliku :: application/pdf
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cee0e037492a17ef790c3af169b1a34
http://www.mdpi.com/1422-0067/19/9/2621

Szczegóły

Skocz do pozycji: 15 15.

Podgląd okładki

Tytuł :: Development of an In Vitro Screening Platform for the Identification of Partial PPARγ Agonists as a Source for Antidiabetic Lead Compounds
Autorzy :: Porskjær Christensen, Lars
Bahij El-Houri, Rime; Pokaż więcej
Temat :: type 2 diabetes
screening platform
partial PPARγ agonists
adipocytes
insulin
glucose uptake
PPARγ transactivation
adipocyte differentiation
in silico
plant extracts
lcsh:Organic chemistry
lcsh:QD241-441
Cell Differentiation/drug effects
Humans
PPAR gamma/agonists
Lipid Metabolism/drug effects
Thiazolidinediones/chemistry
Adipocytes/cytology
Diabetes Mellitus, Type 2/drug therapy
Computer Simulation
Drug Evaluation, Preclinical/methods
Hypoglycemic Agents/chemistry
Molecular Docking Simulation
In Vitro Techniques
Gene Expression Regulation/drug effects
Chemistry (miscellaneous)
Analytical Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Molecular Medicine
Drug Discovery
Pharmaceutical Science
Glucose homeostasis
Lipid metabolism
Pharmacology
Transactivation
Peroxisome proliferator-activated receptor
chemistry.chemical_classification
chemistry
Glucose uptake
Receptor
Insulin
medicine.medical_treatment
medicine
Agonist
medicine.drug_class
Review
PPAR transactivation
Partial PPAR agonists
Plant extracts
Źródło :: Molecules, Vol 23, Iss 10, p 2431 (2018)
Christensen, L P & El-Houri, R 2018, ' Development of an in vitro screening platform for the identification of partial PPARγ agonists as a source for antidiabetic lead compounds ', Molecules, vol. 23, no. 10, pp. 2431 . https://doi.org/10.3390/molecules23102431
Crossref
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Christensen, L P & El-Houri, R B 2018, ' Development of an in vitro screening platform for the identification of partial PPARγ agonists as a source for antidiabetic lead compounds ', Molecules, vol. 23, no. 10, 2431 . https://doi.org/10.3390/molecules23102431
Opis pliku :: application/pdf
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55705887b450f9db5781d945f84f39e6
http://www.mdpi.com/1420-3049/23/10/2431

Szczegóły

Skocz do pozycji: 16 16.

Podgląd okładki

Tytuł :: The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat
Autorzy :: Schilperoort, Maaike
van Dam, Andrea D
Hoeke, Geerte
Shabalina, Irina G
Okolo, Anthony
Hanyaloglu, Aylin C
Dib, Lea H
Mol, Isabel M
Caengprasath, Natarin
Chan, Yi‐Wah
Damak, Sami
Miller, Anne Reifel
Coskun, Tamer
Shimpukade, Bharat
Ulven, Trond
Kooijman, Sander
Rensen, Patrick CN
Christian, Mark; Pokaż więcej
Temat :: brown adipose tissue
Ca2+
GPR120
lipid metabolism
mitochondria
Medicine (General)
R5-920
Genetics
QH426-470
Molecular Medicine
Mitochondrion
Endocrinology
medicine.medical_specialty
medicine
Mitochondrial fission
Lipid metabolism
Carbohydrate metabolism
Internal medicine
Brown adipose tissue
medicine.anatomical_structure
Thermogenesis
Agonist
medicine.drug_class
Chemistry
Research Article
Research Articles
Metabolism
Pharmacology & Drug Discovery
Ca
Lipids
Male
Cell Respiration/drug effects
Adipocytes, Brown/cytology
Receptors, G-Protein-Coupled/agonists
Uncoupling Protein 1/metabolism
Mitochondria/drug effects
Phenylpropionates/pharmacology
Glucose/metabolism
Oxygen Consumption/drug effects
Gene Expression Regulation/drug effects
Body Weight/drug effects
Cell Differentiation/drug effects
Oxidation-Reduction
Mice, Inbred C57BL
Biphenyl Compounds/pharmacology
Adiposity/drug effects
Animals
Models, Biological
Adipose Tissue, White/drug effects
Adipocytes, White/cytology
Adipose Tissue, Brown/drug effects
06 Biological Sciences
11 Medical And Health Sciences
RC
Źródło :: EMBO Molecular Medicine, 10(3)
EMBO Molecular Medicine, Vol 10, Iss 3, Pp n/a-n/a (2018)
Crossref
EMBO Molecular Medicine
Schilperoort, M, van Dam, A D, Hoeke, G, Shabalina, I G, Okolo, A, Hanyaloglu, A C, Dib, L H, Mol, I M, Caengprasath, N, Chan, Y-W, Damak, S, Miller, A R, Coskun, T, Shimpukade, B, Ulven, T, Kooijman, S, Rensen, P C & Christian, M 2018, ' The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat ', EMBO Molecular Medicine, vol. 10, no. 3, e8047 . https://doi.org/10.15252/emmm.201708047
Opis pliku :: application/pdf
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e500a414f38fbfef93af89f8a97f0493
http://hdl.handle.net/1887/76803

Szczegóły

Skocz do pozycji: 17 17.

Podgląd okładki

Tytuł :: Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP)
Autorzy :: Oliana Carnevali
Matthew Huff
Ludivine Renaud
Gary Hardiman
Willian A. da Silveira; Pokaż więcej
Temat :: Article
lcsh:Medicine
lcsh:R
lcsh:Science
lcsh:Q
Multidisciplinary
Fatty liver
medicine.disease
medicine
Transcriptome
Internal medicine
medicine.medical_specialty
Chemistry
Biological pathway
Fatty acid metabolism
chemistry.chemical_compound
Endocrinology
Fatty acid
chemistry.chemical_classification
Phthalate
Metabolism
Ruffle assembly
Animals
Diethylhexyl Phthalate/pharmacology
Gene Expression Regulation/drug effects
Liver/drug effects
Male
Plasticizers/pharmacology
Transcriptome/drug effects
Zebrafish/genetics
Zebrafish Proteins/genetics
endocrine system
Źródło :: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Crossref
Huff, M, da Silveira, W, Carnevali, O, Renaud, L & Hardiman, G 2018, ' Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP) ', Nature Scientific Reports, vol. 8, no. 1, 2118, pp. 1-17 . https://doi.org/10.1038/s41598-018-20266-8, https://doi.org/10.1038/s41598-018-20266-8
Opis pliku :: application/pdf
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7e6c0eb2917260e8f1ef14305f350b
http://europepmc.org/articles/PMC5794889

Szczegóły

Skocz do pozycji: 18 18.

Podgląd okładki

Tytuł :: Exogenous BMP7 in aortae of rats with chronic uremia ameliorates expression of profibrotic genes, but does not reverse established vascular calcification
Autorzy :: Gravesen, Eva
Lerche Mace, Maria
Nordholm, Anders
Hofman-Bang, Jacob
Hruska, Keith
Haagen Nielsen, Carsten
Kjær, Andreas
Olgaard, Klaus
Lewin, Ewa; Pokaż więcej
Temat :: Multidisciplinary
Fibrosis
medicine.disease
medicine
Calcification
Hyperphosphatemia
Abdominal aorta
medicine.artery
Internal medicine
medicine.medical_specialty
Uremia
Endocrinology
Thoracic aorta
Aorta
Transplantation
business.industry
business
Research Article
Biology and Life Sciences
Anatomy
Cardiovascular Anatomy
Blood Vessels
Medicine and Health Sciences
Genetics
Gene Expression
Physiology
Physiological Processes
Renal System
Kidneys
Physical Sciences
Chemistry
Chemical Compounds
Phosphates
Body Fluids
Blood
Blood Plasma
Bone
Bone Density
Biological Tissue
Connective Tissue
Developmental Biology
Animals
Aorta/drug effects
Bone Morphogenetic Protein 7/pharmacology
Chronic Disease
Gene Expression Regulation/drug effects
Male
Phosphates/blood
Rats
Real-Time Polymerase Chain Reaction
Uremia/drug therapy
Vascular Calcification/drug therapy
X-Ray Microtomography
Journal Article
Research Support, Non-U.S. Gov't
lcsh:Medicine
lcsh:R
lcsh:Science
lcsh:Q
Źródło :: Crossref
PLoS ONE
Gravesen, E, Lerche Mace, M, Nordholm, A, Hofman-Bang, J, Hruska, K, Haagen Nielsen, C, Kjær, A, Olgaard, K & Lewin, E 2018, ' Exogenous BMP7 in aortae of rats with chronic uremia ameliorates expression of profibrotic genes, but does not reverse established vascular calcification ', PLOS ONE, vol. 13, no. 1, e0190820 . https://doi.org/10.1371/journal.pone.0190820
PLoS ONE, Vol 13, Iss 1, p e0190820 (2018)
Opis pliku :: application/pdf
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6d3d6c6ca989fa640cf88a3c119c06

Szczegóły

Skocz do pozycji: 19 19.

Podgląd okładki

Tytuł :: TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways
Autorzy :: Matsumoto J
Dohgu S
Takata F
Machida T
Bölükbaşi Hatip FF
Hatip-Al-Khatib I
Yamauchi A
Kataoka Y; Pokaż więcej
Temat :: Developmental Biology
Clinical Neurology
Molecular Biology
General Neuroscience
Pericyte
medicine.anatomical_structure
medicine
STAT3
biology.protein
biology
Tyrosine kinase
Cell biology
Microglia
Astrocyte
Tumor necrosis factor alpha
Interleukin
Chemistry
Neuroinflammation
Interleukin-6
NFκB
Tumor necrosis factor-α
I kappa B
immunoglobulin enhancer binding protein
interleukin 6
Janus kinase
messenger RNA
neutralizing antibody
STAT3 protein
tumor necrosis factor
enzyme inhibitor
animal cell
animal cell culture
animal experiment
Article
brain pericyte
cell activation
central nervous system disease
cytokine release
gene expression
JAK-STAT signaling
nonhuman
primary culture
priority journal
protein phosphorylation
rat
receptor cross-talk
animal
brain
cell culture
cytology
dose response
drug effect
gene expression regulation
metabolism
mouse
signal transduction
Wistar rat
Animals
Cells, Cultured
Dose-Response Relationship, Drug
Enzyme Inhibitors
I-kappa B Proteins
Mice
NF-kappa B
Pericytes
Rats
Rats, Wistar
RNA, Messenger
STAT3 Transcription Factor
Tumor Necrosis Factor-alpha
Brain/*cytology
Enzyme Inhibitors/pharmacology
Gene Expression Regulation/drug effects
I-kappa B Proteins/metabolism
Interleukin-6/*metabolism
Microglia/*drug effects
Pericytes/*drug effects
RNA, Messenger/metabolism
STAT3 Transcription Factor/metabolism
Signal Transduction/*drug effects
Tumor Necrosis Factor-alpha/*pharmacology
Źródło :: Crossref
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706aba2f546c7b20734ef8cf336638f0

Szczegóły

Skocz do pozycji: 20 20.

Podgląd okładki

Tytuł :: Ameliorative potential of Lavandula stoechas in metabolic syndrome via multitarget interactions
Autorzy :: Kulabas, S.S.
Ipek, H.
Tufekci, A.R.
Arslan, S.
Demirtas, I.
Ekren, R.
Sezerman, U.
Tumer, T.B.; Pokaż więcej
Temat :: Animals
Cell Line
Cell Line, Tumor
Cell Survival/drug effects
Cyclooxygenase 2/genetics
Gene Expression Regulation/drug effects
Glucose/metabolism
Glucose-6-Phosphatase/genetics
Interleukin-1beta/genetics
Lavandula
Lipolysis/drug effects
Metabolic Syndrome/drug therapy
Mice
Nitric Oxide/metabolism
Nitric Oxide Synthase Type II/genetics
PPAR gamma/metabolism
Plant Components, Aerial
Plant Extracts/*pharmacology
Protein-Serine-Threonine Kinases/genetics
Proto-Oncogene Proteins
Drug Discovery
Pharmacology
Lavandula stoechas
biology.organism_classification
biology
Insulin resistance
medicine.disease
medicine
Insulin
medicine.medical_treatment
Caffeic acid
chemistry.chemical_compound
chemistry
Protein kinase B
Apigenin
Metabolic syndrome
Glucose uptake
Gluconeogenesis
Lipolysis
Transcriptome
4 hydroxybenzoic acid
antiinflammatory agent
apigenin
caffeic acid
cyclooxygenase 2
ferulic acid
glucose 6 phosphatase
inducible nitric oxide synthase
insulin
interleukin 1beta
isoprenaline
Lavandula stoechas extract
lipoprotein lipase
luteolin
messenger RNA
metformin
nitric oxide
plant extract
rosmarinic acid
salicylic acid
unclassified drug
vanillic acid
glucose
peroxisome proliferator activated receptor gamma
phosphoenolpyruvate carboxylase kinase
protein kinase B
protein serine threonine kinase
adipocyte cell line
animal cell
antiinflammatory activity
Article
C2C12 cell line
controlled study
drug mechanism
glucose transport
H4-II-E cell line
high performance liquid chromatography
in vitro study
lavender
metabolic syndrome X
myotube
nonhuman
RAW 264.7 cell line
time of flight mass spectrometry
transcriptomics
aerial plant part
animal
cell line
cell survival
drug effect
gene expression regulation
genetics
metabolism
mouse
rat
tumor cell line
Glucose-6-Phosphatase
Interleukin-1beta
Metabolic Syndrome
Nitric Oxide Synthase Type II
Plant Extracts
PPAR gamma
Protein-Serine-Threonine Kinases
Proto-Oncogene Proteins c-akt
Rats
Źródło :: Crossref
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800ddd8d9771ed4c565a90da929fbb06

Szczegóły

Wyświetlanie 1-20 z 275

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