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Wyszukujesz frazę ""Gene Expression Regulation drug effects"" wg kryterium: Temat


Tytuł :
Rare and common genetic variations in the Keap1/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively
Autorzy :
Matana, Antonela
Ziros, Panos G.
Chartoumpekis, Dionysios V.
Renaud, Cedric O.
Polašek, Ozren
Hayward, Caroline
Zemunik, Tatijana
Sykiotis, Gerasimos P.
Pokaż więcej
Temat :
Animals
Antioxidant Response Elements/genetics
Antioxidants/pharmacology
Cell Line
Gene Expression Regulation/drug effects
Genome-Wide Association Study
Humans
Isothiocyanates/pharmacology
Kelch-Like ECH-Associated Protein 1/genetics
Kelch-Like ECH-Associated Protein 1/metabolism
NF-E2-Related Factor 2/genetics
NF-E2-Related Factor 2/metabolism
Polymorphism, Single Nucleotide
Rats
Signal Transduction/drug effects
Signal Transduction/genetics
Thyroglobulin/blood
Thyroglobulin/genetics
Thyroglobulin/metabolism
Thyroid Gland/drug effects
Thyroid Gland/metabolism
Thyrotropin/pharmacology
Keap1
Nrf2
SNP
Thyroglobulin
Thyroid
Pharmacology
Biochemistry
Cancer research
Single-nucleotide polymorphism
Gene expression
Genome-wide association study
Enhancer
Biology
Antioxidant Response Elements
medicine.medical_treatment
medicine
Transcription factor
Population
education.field_of_study
education
Źródło :
Biochemical pharmacology, vol. 173, pp. 113605
Matana, A, Ziros, P G, Chartoumpekis, D V, Renaud, C O, Polašek, O, Hayward, C, Zemunik, T & Sykiotis, G P 2019, ' Rare and common genetic variations in the Keap1/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively ', Biochemical Pharmacology . https://doi.org/10.1016/j.bcp.2019.08.007
Crossref
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32432a045b57211f0f1a429ccce1cbdc
https://serval.unil.ch/notice/serval:BIB_4E02568FE6AA
Tytuł :
Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes
Autorzy :
Daniel Lopatta
Alexander Lukas
Danyel G. J. Jennen
Gökhan Ertaylan
Tobias Stumm
Rachel Cavill
Evgueni Smirnov
Ralf Peeters
Natal A.W. van Riel
Jelmer Neeven
Shauna D O'Donovan
Michael Lenz
Theo M.C.M. de Kok
Kurt Driessens
Florian Wimmenauer
Pokaż więcej
Temat :
Algorithms
Animals
Clinical Trials as Topic/statistics & numerical data
Deep Learning
Gene Expression Regulation/drug effects
Hepatocytes/drug effects
Humans
Machine Learning
Neural Networks, Computer
Rats
Multidisciplinary
Artificial neural network
In vivo
Convolutional neural network
Deep learning
Computational biology
Artificial intelligence
business.industry
business
Bioassay
Biology
Gene
Toxicogenomics
Gene expression
Medicine
Science
Chair Nutrition Metabolism and Genomics
HNE Voeding, Metabolisme en Genomics
Voeding, Metabolisme en Genomica
HNE Nutrition, Metabolism and Genomics
Nutrition, Metabolism and Genomics
REPRESENTATIONS
TOXICOGENOMICS
TOXICOLOGY
TOXICITY
HNE Voeding
Metabolisme en Genomics
Voeding
Metabolisme en Genomica
HNE Nutrition
Metabolism and Genomics
Nutrition
Neural Networks
Computer
Research Article
Biology and Life Sciences
Genetics
Gene Expression
Predictive Toxicology
Medicine and Health Sciences
Pathology and Laboratory Medicine
Pharmaceutics
Dose Prediction Methods
Computer and Information Sciences
Artificial Intelligence
Genetic Toxicology
Neuroscience
Engineering and Technology
Measurement
Time Measurement
Źródło :
PLoS ONE, 15(8). Public Library of Science
Crossref
PLoS ONE, Vol 15, Iss 8, p e0236392 (2020)
PLoS ONE, 15(8)
PLOS ONE, 15(8):e0236392. Public Library of Science
PLoS ONE, 15(8):e0236392. Public Library of Science
PLoS ONE
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab28b049df1eb0bf4886171aacfd7cb
https://pure.amc.nl/en/publications/use-of-deep-learning-methods-to-translate-druginduced-gene-expression-changes-from-rat-to-human-primary-hepatocytes(73c11227-9451-40b5-a199-15f21993acf5).html
Tytuł :
Inflammation leads to distinct populations of extracellular vesicles from microglia
Autorzy :
Yang, Yiyi
Boza-Serrano, Antonio
Dunning, Christopher J. R.
Clausen, Bettina Hjelm
Lambertsen, Kate Lykke
Deierborg, Tomas
Pokaż więcej
Temat :
Microglia
Extracellular vesicles (EVs)
Neuroinflammation
TNF
lcsh:Neurology. Diseases of the nervous system
lcsh:RC346-429
Research
Cellular and Molecular Neuroscience
Neurology
Immunology
General Neuroscience
Tumor necrosis factor alpha
Western blot
medicine.diagnostic_test
medicine
Interleukin
Lipopolysaccharide
chemistry.chemical_compound
chemistry
medicine.anatomical_structure
Cytokine
medicine.medical_treatment
Inflammation
medicine.symptom
Cell biology
Microglia/drug effects
Protein Transport/drug effects
Nitric Oxide Synthase Type II/metabolism
Tumor Necrosis Factor-alpha/deficiency
Etanercept/pharmacology
Mice, Inbred C57BL
Infarction, Middle Cerebral Artery/complications
Male
Lipopolysaccharides/pharmacology
Signal Transduction/drug effects
Mice, Knockout
Animals
Inflammation/etiology
Immunosuppressive Agents/pharmacology
Mice
Cytokines/metabolism
Extracellular Vesicles/pathology
Cell Line, Transformed
Gene Expression Regulation/drug effects
Disease Models, Animal
Źródło :
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-19 (2018)
Journal of Neuroinflammation
Crossref
Yang, Y, Boza-Serrano, A, Dunning, C J R, Clausen, B H, Lambertsen, K L & Deierborg, T 2018, ' Inflammation leads to distinct populations of extracellular vesicles from microglia ', Journal of Neuroinflammation, vol. 15, 168 . https://doi.org/10.1186/s12974-018-1204-7
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5b9f02a66c45696b513383261ae0bf
http://link.springer.com/article/10.1186/s12974-018-1204-7
Tytuł :
Downregulation of PPARα during Experimental Left Ventricular Hypertrophy is Critically Dependent on Nox2 NADPH Oxidase Signalling
Autorzy :
Philip D. Dunne
David J. Grieve
Kevin Edgar
Ross McMullan
Karla O'Neill
Matthew Alderdice
Barbara McDermott
Adam Harvey
Raheleh Amirkhah
Emma Robinson
Pokaż więcej
Temat :
Inorganic Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Catalysis
Heart failure
medicine.disease
medicine
Muscle hypertrophy
Transcriptome
NADPH oxidase
biology.protein
biology
Oxidative stress
medicine.disease_cause
Endocrinology
medicine.medical_specialty
Left ventricular hypertrophy
Downregulation and upregulation
Regulator
Internal medicine
Chemistry
Animals
Cell Line
Disease Models, Animal
Gene Expression Regulation/drug effects
Hypertrophy, Left Ventricular/etiology
Male
Mice
Myocytes, Cardiac/cytology
NADPH Oxidase 2/genetics
Oxidative Stress
PPAR alpha/genetics
Phenylephrine/pharmacology
Rats
Signal Transduction
Nox2 NADPH oxidase
PPARα
left ventricular hypertrophy
oxidative stress
microarray
transverse aortic constriction
lcsh:Biology (General)
lcsh:QH301-705.5
lcsh:Chemistry
lcsh:QD1-999
Article
chronic heart failure
cardiovascular diseases
Źródło :
Crossref
Harvey, A P, Robinson, E, Edgar, K S, McMullan, R, O'Neill, K M, Alderdice, M, Amirkhah, R, Dunne, P D, McDermott, B J & Grieve, D J 2020, ' Downregulation of PPARα during Experimental Left Ventricular Hypertrophy Is Critically Dependent on Nox2 NADPH Oxidase Signalling ', International journal of molecular sciences, vol. 21, no. 12 . https://doi.org/10.3390/ijms21124406
International Journal of Molecular Sciences, Vol 21, Iss 4406, p 4406 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 12
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417eb1a2c47cf45ab1f1c1683b01ace2
https://www.mdpi.com/1422-0067/21/12/4406/pdf
Tytuł :
Investigation of the role of GBF1 in the replication of positive-sense single-stranded RNA viruses
Autorzy :
Yves Rouillé
Rayan Farhat
Didier Hober
Jean Dubuisson
Sandrine Belouzard
Laurence Cocquerel
Juliette Ferlin
Antoine Bertin
Pokaż więcej
Temat :
hepatitis C virus
coxsackievirus B4
human coronavirus
ADP-ribosylation factor
Animals
Brefeldin A
Gene Knockdown Techniques
Guanine Nucleotide Exchange Factors/genetics
Guanine Nucleotide Exchange Factors/metabolism
Humans
Mice
Pyridines/pharmacology
Quinolines/pharmacology
RNA Interference
RNA Viruses/physiology
Virus Replication/physiology
Cell Line
Cell Survival
Gene Expression Regulation/drug effects
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
MESH: Animals
MESH: Brefeldin A
MESH: Gene Knockdown Techniques
MESH: Guanine Nucleotide Exchange Factors/genetics
MESH: Guanine Nucleotide Exchange Factors/metabolism
MESH: Humans
MESH: Mice
MESH: Pyridines/pharmacology
MESH: Quinolines/pharmacology
MESH: RNA Interference
MESH: RNA Viruses/physiology
MESH: Virus Replication/physiology
MESH: Cell Line
MESH: Cell Survival
MESH: Gene Expression Regulation/drug effects
Virology
Human coronavirus 229E
biology.organism_classification
biology
RNA
Sindbis virus
Virus
Viral replication
Host factor
Hepatitis C virus
medicine.disease_cause
medicine
Coxsackievirus
viruses
Źródło :
Journal of General Virology
Journal of General Virology, Microbiology Society, 2018, 99 (8), pp.1086-1096. ⟨10.1099/jgv.0.001099⟩
Crossref
Opis pliku :
application/octet-stream
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f61a159d161901a3885c57f1e24dc7b
http://hdl.handle.net/20.500.12210/28779
Tytuł :
Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free 'GeneSwitch' vector
Autorzy :
Sebastian Kügler
Catherine Pythoud
Anupam Raina
Nicole Déglon
Shi Cheng
Maria Rey
Mathias Bähr
Julia Tereshchenko
Virginie Zimmer
Frank Streit
Gabriel Vachey
Andrzej Mazur
Pavlina Konstantinova
Jolanda M. Liefhebber
Pokaż więcej
Temat :
3,4-Dihydroxyphenylacetic Acid/metabolism
Adrenergic Agents/toxicity
Animals
Disease Models, Animal
Gene Expression Regulation/drug effects
Gene Expression Regulation/genetics
Glial Cell Line-Derived Neurotrophic Factor/genetics
Glial Cell Line-Derived Neurotrophic Factor/metabolism
Green Fluorescent Proteins/genetics
Green Fluorescent Proteins/metabolism
Homovanillic Acid/metabolism
Hormone Antagonists/therapeutic use
Huntingtin Protein/genetics
Huntingtin Protein/metabolism
Huntington Disease/genetics
Huntington Disease/metabolism
Huntington Disease/pathology
Huntington Disease/therapy
Mice
Mice, Transgenic
Mifepristone/therapeutic use
Oxidopamine/toxicity
Parkinson Disease/etiology
Parkinson Disease/genetics
Parkinson Disease/metabolism
Parkinson Disease/therapy
Synapsins/genetics
Synapsins/metabolism
Synucleins/genetics
Synucleins/metabolism
Transduction, Genetic
AAV
GDNF
GeneSwitch
Huntington's disease
Mifepristone
Parkinson's disease
Regulated expression
Developmental Neuroscience
Neurology
Transduction (genetics)
medicine.disease
medicine
Transgene
Gene product
Glial cell line-derived neurotrophic factor
biology.protein
biology
Genetic enhancement
business.industry
business
Cancer research
Neurotrophic factors
Źródło :
Experimental neurology, vol. 309, pp. 79-90
Crossref
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6bc910cb868b3ba3bfa0229d4aa882
https://serval.unil.ch/notice/serval:BIB_74113391BE61
Tytuł :
Activation of Bone Marrow-Derived Cells Angiotensin (Ang) II Type 1 Receptor by Ang II Promotes Atherosclerotic Plaque Vulnerability
Autorzy :
Pellegrin, Maxime
Bouzourène, Karima
Aubert, Jean-François
Nahimana, Aimable
Duchosal, Michel
Mazzolai, Lucia
Pokaż więcej
Temat :
atherosclerosis
vulnerable plaque
Angiotensin II
inflammation
2-kidney, 1-clip ApoE−/− mice
bone marrow transplantation
lcsh:Biology (General)
lcsh:QH301-705.5
lcsh:Chemistry
lcsh:QD1-999
Inorganic Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Catalysis
T cell
medicine.anatomical_structure
medicine
Bone marrow
M2 Macrophage
Receptor
Endocrinology
medicine.medical_specialty
Renin–angiotensin system
Chemistry
Internal medicine
Inflammation
medicine.symptom
Vulnerable plaque
medicine.disease_cause
Angiotensins/adverse effects
Animals
Apolipoproteins E/genetics
Bone Marrow Cells/cytology
Bone Marrow Cells/drug effects
Bone Marrow Transplantation
Cytokines/genetics
Disease Models, Animal
Gene Expression Regulation/drug effects
Gene Knockdown Techniques
Humans
Lipid Metabolism
Liver/drug effects
Liver/metabolism
Mice
Plaque, Atherosclerotic/chemically induced
Plaque, Atherosclerotic/genetics
Plaque, Atherosclerotic/immunology
Receptor, Angiotensin, Type 1/genetics
Article
cardiovascular system
hormones, hormone substitutes, and hormone antagonists
Źródło :
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2621 (2018)
Crossref
International journal of molecular sciences, vol. 19, no. 9, pp. E2621
International Journal of Molecular Sciences
Volume 19
Issue 9
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cee0e037492a17ef790c3af169b1a34
http://www.mdpi.com/1422-0067/19/9/2621
Tytuł :
Development of an In Vitro Screening Platform for the Identification of Partial PPARγ Agonists as a Source for Antidiabetic Lead Compounds
Autorzy :
Porskjær Christensen, Lars
Bahij El-Houri, Rime
Pokaż więcej
Temat :
type 2 diabetes
screening platform
partial PPARγ agonists
adipocytes
insulin
glucose uptake
PPARγ transactivation
adipocyte differentiation
in silico
plant extracts
lcsh:Organic chemistry
lcsh:QD241-441
Cell Differentiation/drug effects
Humans
PPAR gamma/agonists
Lipid Metabolism/drug effects
Thiazolidinediones/chemistry
Adipocytes/cytology
Diabetes Mellitus, Type 2/drug therapy
Computer Simulation
Drug Evaluation, Preclinical/methods
Hypoglycemic Agents/chemistry
Molecular Docking Simulation
In Vitro Techniques
Gene Expression Regulation/drug effects
Chemistry (miscellaneous)
Analytical Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Molecular Medicine
Drug Discovery
Pharmaceutical Science
Glucose homeostasis
Lipid metabolism
Pharmacology
Transactivation
Peroxisome proliferator-activated receptor
chemistry.chemical_classification
chemistry
Glucose uptake
Receptor
Insulin
medicine.medical_treatment
medicine
Agonist
medicine.drug_class
Review
PPAR transactivation
Partial PPAR agonists
Plant extracts
Źródło :
Molecules, Vol 23, Iss 10, p 2431 (2018)
Christensen, L P & El-Houri, R 2018, ' Development of an in vitro screening platform for the identification of partial PPARγ agonists as a source for antidiabetic lead compounds ', Molecules, vol. 23, no. 10, pp. 2431 . https://doi.org/10.3390/molecules23102431
Crossref
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Christensen, L P & El-Houri, R B 2018, ' Development of an in vitro screening platform for the identification of partial PPARγ agonists as a source for antidiabetic lead compounds ', Molecules, vol. 23, no. 10, 2431 . https://doi.org/10.3390/molecules23102431
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55705887b450f9db5781d945f84f39e6
http://www.mdpi.com/1420-3049/23/10/2431
Tytuł :
The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat
Autorzy :
Schilperoort, Maaike
van Dam, Andrea D
Hoeke, Geerte
Shabalina, Irina G
Okolo, Anthony
Hanyaloglu, Aylin C
Dib, Lea H
Mol, Isabel M
Caengprasath, Natarin
Chan, Yi‐Wah
Damak, Sami
Miller, Anne Reifel
Coskun, Tamer
Shimpukade, Bharat
Ulven, Trond
Kooijman, Sander
Rensen, Patrick CN
Christian, Mark
Pokaż więcej
Temat :
brown adipose tissue
Ca2+
GPR120
lipid metabolism
mitochondria
Medicine (General)
R5-920
Genetics
QH426-470
Molecular Medicine
Mitochondrion
Endocrinology
medicine.medical_specialty
medicine
Mitochondrial fission
Lipid metabolism
Carbohydrate metabolism
Internal medicine
Brown adipose tissue
medicine.anatomical_structure
Thermogenesis
Agonist
medicine.drug_class
Chemistry
Research Article
Research Articles
Metabolism
Pharmacology & Drug Discovery
Ca
Lipids
Male
Cell Respiration/drug effects
Adipocytes, Brown/cytology
Receptors, G-Protein-Coupled/agonists
Uncoupling Protein 1/metabolism
Mitochondria/drug effects
Phenylpropionates/pharmacology
Glucose/metabolism
Oxygen Consumption/drug effects
Gene Expression Regulation/drug effects
Body Weight/drug effects
Cell Differentiation/drug effects
Oxidation-Reduction
Mice, Inbred C57BL
Biphenyl Compounds/pharmacology
Adiposity/drug effects
Animals
Models, Biological
Adipose Tissue, White/drug effects
Adipocytes, White/cytology
Adipose Tissue, Brown/drug effects
06 Biological Sciences
11 Medical And Health Sciences
RC
Źródło :
EMBO Molecular Medicine, 10(3)
EMBO Molecular Medicine, Vol 10, Iss 3, Pp n/a-n/a (2018)
Crossref
EMBO Molecular Medicine
Schilperoort, M, van Dam, A D, Hoeke, G, Shabalina, I G, Okolo, A, Hanyaloglu, A C, Dib, L H, Mol, I M, Caengprasath, N, Chan, Y-W, Damak, S, Miller, A R, Coskun, T, Shimpukade, B, Ulven, T, Kooijman, S, Rensen, P C & Christian, M 2018, ' The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat ', EMBO Molecular Medicine, vol. 10, no. 3, e8047 . https://doi.org/10.15252/emmm.201708047
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e500a414f38fbfef93af89f8a97f0493
http://hdl.handle.net/1887/76803
Tytuł :
Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP)
Autorzy :
Oliana Carnevali
Matthew Huff
Ludivine Renaud
Gary Hardiman
Willian A. da Silveira
Pokaż więcej
Temat :
Article
lcsh:Medicine
lcsh:R
lcsh:Science
lcsh:Q
Multidisciplinary
Fatty liver
medicine.disease
medicine
Transcriptome
Internal medicine
medicine.medical_specialty
Chemistry
Biological pathway
Fatty acid metabolism
chemistry.chemical_compound
Endocrinology
Fatty acid
chemistry.chemical_classification
Phthalate
Metabolism
Ruffle assembly
Animals
Diethylhexyl Phthalate/pharmacology
Gene Expression Regulation/drug effects
Liver/drug effects
Male
Plasticizers/pharmacology
Transcriptome/drug effects
Zebrafish/genetics
Zebrafish Proteins/genetics
endocrine system
Źródło :
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Crossref
Huff, M, da Silveira, W, Carnevali, O, Renaud, L & Hardiman, G 2018, ' Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP) ', Nature Scientific Reports, vol. 8, no. 1, 2118, pp. 1-17 . https://doi.org/10.1038/s41598-018-20266-8, https://doi.org/10.1038/s41598-018-20266-8
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7e6c0eb2917260e8f1ef14305f350b
http://europepmc.org/articles/PMC5794889
Tytuł :
Exogenous BMP7 in aortae of rats with chronic uremia ameliorates expression of profibrotic genes, but does not reverse established vascular calcification
Autorzy :
Gravesen, Eva
Lerche Mace, Maria
Nordholm, Anders
Hofman-Bang, Jacob
Hruska, Keith
Haagen Nielsen, Carsten
Kjær, Andreas
Olgaard, Klaus
Lewin, Ewa
Pokaż więcej
Temat :
Multidisciplinary
Fibrosis
medicine.disease
medicine
Calcification
Hyperphosphatemia
Abdominal aorta
medicine.artery
Internal medicine
medicine.medical_specialty
Uremia
Endocrinology
Thoracic aorta
Aorta
Transplantation
business.industry
business
Research Article
Biology and Life Sciences
Anatomy
Cardiovascular Anatomy
Blood Vessels
Medicine and Health Sciences
Genetics
Gene Expression
Physiology
Physiological Processes
Renal System
Kidneys
Physical Sciences
Chemistry
Chemical Compounds
Phosphates
Body Fluids
Blood
Blood Plasma
Bone
Bone Density
Biological Tissue
Connective Tissue
Developmental Biology
Animals
Aorta/drug effects
Bone Morphogenetic Protein 7/pharmacology
Chronic Disease
Gene Expression Regulation/drug effects
Male
Phosphates/blood
Rats
Real-Time Polymerase Chain Reaction
Uremia/drug therapy
Vascular Calcification/drug therapy
X-Ray Microtomography
Journal Article
Research Support, Non-U.S. Gov't
lcsh:Medicine
lcsh:R
lcsh:Science
lcsh:Q
Źródło :
Crossref
PLoS ONE
Gravesen, E, Lerche Mace, M, Nordholm, A, Hofman-Bang, J, Hruska, K, Haagen Nielsen, C, Kjær, A, Olgaard, K & Lewin, E 2018, ' Exogenous BMP7 in aortae of rats with chronic uremia ameliorates expression of profibrotic genes, but does not reverse established vascular calcification ', PLOS ONE, vol. 13, no. 1, e0190820 . https://doi.org/10.1371/journal.pone.0190820
PLoS ONE, Vol 13, Iss 1, p e0190820 (2018)
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6d3d6c6ca989fa640cf88a3c119c06
Tytuł :
TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways
Autorzy :
Matsumoto J
Dohgu S
Takata F
Machida T
Bölükbaşi Hatip FF
Hatip-Al-Khatib I
Yamauchi A
Kataoka Y
Pokaż więcej
Temat :
Developmental Biology
Clinical Neurology
Molecular Biology
General Neuroscience
Pericyte
medicine.anatomical_structure
medicine
STAT3
biology.protein
biology
Tyrosine kinase
Cell biology
Microglia
Astrocyte
Tumor necrosis factor alpha
Interleukin
Chemistry
Neuroinflammation
Interleukin-6
NFκB
Tumor necrosis factor-α
I kappa B
immunoglobulin enhancer binding protein
interleukin 6
Janus kinase
messenger RNA
neutralizing antibody
STAT3 protein
tumor necrosis factor
enzyme inhibitor
animal cell
animal cell culture
animal experiment
Article
brain pericyte
cell activation
central nervous system disease
cytokine release
gene expression
JAK-STAT signaling
nonhuman
primary culture
priority journal
protein phosphorylation
rat
receptor cross-talk
animal
brain
cell culture
cytology
dose response
drug effect
gene expression regulation
metabolism
mouse
signal transduction
Wistar rat
Animals
Cells, Cultured
Dose-Response Relationship, Drug
Enzyme Inhibitors
I-kappa B Proteins
Mice
NF-kappa B
Pericytes
Rats
Rats, Wistar
RNA, Messenger
STAT3 Transcription Factor
Tumor Necrosis Factor-alpha
Brain/*cytology
Enzyme Inhibitors/pharmacology
Gene Expression Regulation/drug effects
I-kappa B Proteins/metabolism
Interleukin-6/*metabolism
Microglia/*drug effects
Pericytes/*drug effects
RNA, Messenger/metabolism
STAT3 Transcription Factor/metabolism
Signal Transduction/*drug effects
Tumor Necrosis Factor-alpha/*pharmacology
Źródło :
Crossref
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706aba2f546c7b20734ef8cf336638f0
Tytuł :
Ameliorative potential of Lavandula stoechas in metabolic syndrome via multitarget interactions
Autorzy :
Kulabas, S.S.
Ipek, H.
Tufekci, A.R.
Arslan, S.
Demirtas, I.
Ekren, R.
Sezerman, U.
Tumer, T.B.
Pokaż więcej
Temat :
Animals
Cell Line
Cell Line, Tumor
Cell Survival/drug effects
Cyclooxygenase 2/genetics
Gene Expression Regulation/drug effects
Glucose/metabolism
Glucose-6-Phosphatase/genetics
Interleukin-1beta/genetics
Lavandula
Lipolysis/drug effects
Metabolic Syndrome/drug therapy
Mice
Nitric Oxide/metabolism
Nitric Oxide Synthase Type II/genetics
PPAR gamma/metabolism
Plant Components, Aerial
Plant Extracts/*pharmacology
Protein-Serine-Threonine Kinases/genetics
Proto-Oncogene Proteins
Drug Discovery
Pharmacology
Lavandula stoechas
biology.organism_classification
biology
Insulin resistance
medicine.disease
medicine
Insulin
medicine.medical_treatment
Caffeic acid
chemistry.chemical_compound
chemistry
Protein kinase B
Apigenin
Metabolic syndrome
Glucose uptake
Gluconeogenesis
Lipolysis
Transcriptome
4 hydroxybenzoic acid
antiinflammatory agent
apigenin
caffeic acid
cyclooxygenase 2
ferulic acid
glucose 6 phosphatase
inducible nitric oxide synthase
insulin
interleukin 1beta
isoprenaline
Lavandula stoechas extract
lipoprotein lipase
luteolin
messenger RNA
metformin
nitric oxide
plant extract
rosmarinic acid
salicylic acid
unclassified drug
vanillic acid
glucose
peroxisome proliferator activated receptor gamma
phosphoenolpyruvate carboxylase kinase
protein kinase B
protein serine threonine kinase
adipocyte cell line
animal cell
antiinflammatory activity
Article
C2C12 cell line
controlled study
drug mechanism
glucose transport
H4-II-E cell line
high performance liquid chromatography
in vitro study
lavender
metabolic syndrome X
myotube
nonhuman
RAW 264.7 cell line
time of flight mass spectrometry
transcriptomics
aerial plant part
animal
cell line
cell survival
drug effect
gene expression regulation
genetics
metabolism
mouse
rat
tumor cell line
Glucose-6-Phosphatase
Interleukin-1beta
Metabolic Syndrome
Nitric Oxide Synthase Type II
Plant Extracts
PPAR gamma
Protein-Serine-Threonine Kinases
Proto-Oncogene Proteins c-akt
Rats
Źródło :
Crossref
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800ddd8d9771ed4c565a90da929fbb06

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