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Wyszukujesz frazę ""Gene Knockdown Techniques"" wg kryterium: Temat


Tytuł :
Knockdown of carbohydrate sulfotransferase 12 decreases the proliferation and mobility of glioblastoma cells via the WNT/β-catenin pathway.
Autorzy :
Wang J; Department of Neurology, Changle People's Hospital, Weifang Shandong, China.
Xia X; Department of Neurology, Changle People's Hospital, Weifang Shandong, China.
Tao X; Department of Neurology, Changle People's Hospital, Weifang Shandong, China.
Zhao P; Department of Oncology, Changle People's Hospital, Weifang Shandong, China.
Deng C; Department of Neurology, Changle People's Hospital, Weifang Shandong, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 3934-3946.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement*/genetics
Gene Knockdown Techniques*
Wnt Signaling Pathway*
Brain Neoplasms/*enzymology
Brain Neoplasms/*pathology
Glioblastoma/*enzymology
Glioblastoma/*pathology
Sulfotransferases/*deficiency
Brain Neoplasms/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Glioblastoma/genetics ; Humans ; Male ; Middle Aged ; Sulfotransferases/genetics ; Sulfotransferases/metabolism ; Survival Analysis ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis.
Autorzy :
Liu D; Department of Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, No. 1 Zhongshan Second Road, Yuexiu District, Guangzhou, 510080, Guangdong, China.
Liang Y; Department of Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, No. 1 Zhongshan Second Road, Yuexiu District, Guangzhou, 510080, Guangdong, China.
Chen M; Department of Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, No. 1 Zhongshan Second Road, Yuexiu District, Guangzhou, 510080, Guangdong, China.
Yang F; Department of Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, No. 1 Zhongshan Second Road, Yuexiu District, Guangzhou, 510080, Guangdong, China.
Yao S; Department of Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, No. 1 Zhongshan Second Road, Yuexiu District, Guangzhou, 510080, Guangdong, China. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Oct; Vol. 476 (10), pp. 3845-3856. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
Gene Knockdown Techniques*
Endometriosis/*metabolism
Kruppel-Like Transcription Factors/*metabolism
MicroRNAs/*metabolism
RNA, Circular/*metabolism
Adult ; Endometriosis/genetics ; Female ; Humans ; Kruppel-Like Transcription Factors/genetics ; MicroRNAs/genetics ; Middle Aged ; RNA, Circular/genetics ; Stromal Cells/metabolism
Czasopismo naukowe
Tytuł :
Effects of IGFBP3 knockdown on human endometrial mesenchymal stromal cells stress-induced senescence.
Autorzy :
Ushakov RE; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia.
Aksenov ND; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia.
Pugovkina NA; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia.
Burova EB; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Sep 17; Vol. 570, pp. 143-147. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Gene Knockdown Techniques*
Stress, Physiological*
Endometrium/*pathology
Insulin-Like Growth Factor Binding Protein 3/*metabolism
Mesenchymal Stem Cells/*metabolism
Cell Line ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Female ; Humans ; Retinoblastoma Protein/metabolism ; Tumor Suppressor Protein p53/metabolism ; Up-Regulation ; beta-Galactosidase/metabolism
Czasopismo naukowe
Tytuł :
GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway.
Autorzy :
Liu HY; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China.
Zhang HS; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China. Electronic address: .
Liu MY; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China.
Li HM; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China.
Wang XY; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China.
Wang M; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China.
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Sep 15; Vol. 708, pp. 108964. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockdown Techniques*
Autophagy/*genetics
Cell Movement/*genetics
Colorectal Neoplasms/*pathology
Glutaminase/*deficiency
Glutaminase/*genetics
NF-E2-Related Factor 2/*metabolism
Cell Line, Tumor ; Cell Proliferation/genetics ; Humans ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Pseudogene ANXA2P2 knockdown shows tumor-suppressive function by inhibition of the PI3K/PKB pathway in glioblastoma cells.
Autorzy :
Ni H; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Zhi R; Department of Gastroenterology, Lianshui County People's Hospital Affiliated to Kangda College of Nanjing Medical University, Huai'an, China.
Zuo J; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Liu W; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Xie P; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Zhi Z; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Aug; Vol. 35 (8), pp. e22824. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockdown Techniques*
Genes, Tumor Suppressor*
Glioblastoma*/genetics
Glioblastoma*/metabolism
Pseudogenes*
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Cell Line, Tumor ; Humans ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics
Czasopismo naukowe
Tytuł :
Divalent Metal Transporter 1 Knock-Down Modulates IL-1β Mediated Pancreatic Beta-Cell Pro-Apoptotic Signaling Pathways through the Autophagic Machinery.
Autorzy :
Kang T; Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.; The Danish Diabetes Academy, 5230 Odense M, Denmark.
Huang H; Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Mandrup-Poulsen T; Immuno-Endocrinology Laboratory, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
Larsen MR; Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 27; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockdown Techniques*
Apoptosis/*immunology
Autophagy/*immunology
Cation Transport Proteins/*deficiency
Insulin-Secreting Cells/*immunology
Interleukin-1beta/*immunology
Interleukin-6/*immunology
Signal Transduction/*immunology
Animals ; Apoptosis/genetics ; Autophagy/genetics ; Cation Transport Proteins/immunology ; Interleukin-1beta/genetics ; Interleukin-6/genetics ; Mice ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Knockdown of PEX16 Induces Autophagic Degradation of Peroxisomes.
Autorzy :
Wei X; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Maharjan Y; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Dorotea D; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Dutta RK; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kim D; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kim H; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Mu Y; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Park C; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Park R; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 26; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Gene Knockdown Techniques*
Membrane Proteins/*deficiency
Peroxisomes/*metabolism
Retinal Pigment Epithelium/*metabolism
ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Cell Line ; Humans ; Membrane Proteins/metabolism ; Peroxisomes/genetics
Czasopismo naukowe
Tytuł :
SEMA4D Knockdown Attenuates β -Catenin-Dependent Tumor Progression in Colorectal Cancer.
Autorzy :
Rezaeepoor M; Department of Immunology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Rashidi G; Department of Immunology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Pourjafar M; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Mohammadi C; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Solgi G; Department of Immunology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Najafi R; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
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Źródło :
BioMed research international [Biomed Res Int] 2021 Jul 21; Vol. 2021, pp. 8507373. Date of Electronic Publication: 2021 Jul 21 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Disease Progression*
Gene Knockdown Techniques*
Antigens, CD/*metabolism
Colorectal Neoplasms/*metabolism
Colorectal Neoplasms/*pathology
Semaphorins/*metabolism
beta Catenin/*metabolism
Antigens, CD/genetics ; Apoptosis ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Survival ; Colorectal Neoplasms/genetics ; Down-Regulation ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; RNA, Small Interfering/metabolism ; Semaphorins/genetics
Czasopismo naukowe
Tytuł :
A MYBL2 complex for RRM2 transactivation and the synthetic effect of MYBL2 knockdown with WEE1 inhibition against colorectal cancer.
Autorzy :
Liu Q; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Guo L; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Qi H; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University Cancer Center, Key Laboratory of Disease Proteomics of Zhejiang Province, Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, Zhejiang University School of Medicine, Hangzhou, China.
Lou M; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University Cancer Center, Key Laboratory of Disease Proteomics of Zhejiang Province, Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, Zhejiang University School of Medicine, Hangzhou, China.
Wang R; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hai B; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xu K; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University Cancer Center, Key Laboratory of Disease Proteomics of Zhejiang Province, Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, Zhejiang University School of Medicine, Hangzhou, China.
Zhu L; Key Laboratory of Pancreatic Disease of Zhejiang Province, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ding Y; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Pancreatic Disease of Zhejiang Province, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Li C; Department of Human Genetics, Zhejiang University School of Medicine, Hangzhou, China.
Xie L; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University Cancer Center, Key Laboratory of Disease Proteomics of Zhejiang Province, Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, Zhejiang University School of Medicine, Hangzhou, China.
Shen J; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University Cancer Center, Key Laboratory of Disease Proteomics of Zhejiang Province, Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, Zhejiang University School of Medicine, Hangzhou, China.
Xiang X; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. .; Zhejiang University Cancer Center, Key Laboratory of Disease Proteomics of Zhejiang Province, Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, Zhejiang University School of Medicine, Hangzhou, China. .
Shao J; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. .; Zhejiang University Cancer Center, Key Laboratory of Disease Proteomics of Zhejiang Province, Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, Zhejiang University School of Medicine, Hangzhou, China. .
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Źródło :
Cell death & disease [Cell Death Dis] 2021 Jul 07; Vol. 12 (7), pp. 683. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockdown Techniques*
Antineoplastic Agents/*pharmacology
Cell Cycle Proteins/*antagonists & inhibitors
Cell Cycle Proteins/*metabolism
Colorectal Neoplasms/*enzymology
Enzyme Inhibitors/*pharmacology
Protein-Tyrosine Kinases/*antagonists & inhibitors
Pyrazoles/*pharmacology
Pyrimidinones/*pharmacology
Ribonucleoside Diphosphate Reductase/*metabolism
Trans-Activators/*metabolism
Animals ; Cell Cycle Proteins/genetics ; Cell Proliferation/drug effects ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Databases, Genetic ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Protein-Tyrosine Kinases/metabolism ; Ribonucleoside Diphosphate Reductase/genetics ; Signal Transduction ; Trans-Activators/genetics ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Circ-SPG11 knockdown hampers IL-1β-induced osteoarthritis progression via targeting miR-337-3p/ADAMTS5.
Autorzy :
Liu Y; Department of Orthopedics, Shijiazhuang People's Hospital, No. 365 Jianhua South Road, Shijiazhang, Hebei, 050000, People's Republic of China.
Li Q; Department of Orthopedics, Shijiazhuang People's Hospital, No. 365 Jianhua South Road, Shijiazhang, Hebei, 050000, People's Republic of China.
Gao Z; Department of Orthopedics, Shijiazhuang People's Hospital, No. 365 Jianhua South Road, Shijiazhang, Hebei, 050000, People's Republic of China.
Lei F; Department of Orthopedics, Shijiazhuang People's Hospital, No. 365 Jianhua South Road, Shijiazhang, Hebei, 050000, People's Republic of China. .
Gao X; Department of Orthopedics, Shijiazhuang People's Hospital, No. 365 Jianhua South Road, Shijiazhang, Hebei, 050000, People's Republic of China.
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Źródło :
Journal of orthopaedic surgery and research [J Orthop Surg Res] 2021 Jun 17; Vol. 16 (1), pp. 392. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockdown Techniques*
ADAMTS5 Protein/*genetics
ADAMTS5 Protein/*metabolism
Interleukin-1beta/*adverse effects
MicroRNAs/*genetics
MicroRNAs/*metabolism
Osteoarthritis, Knee/*genetics
Proteins/*genetics
RNA, Circular/*genetics
Cell Line ; Disease Progression ; Down-Regulation/genetics ; Gene Expression Regulation/genetics ; Humans ; Osteoarthritis, Knee/etiology ; Proteins/physiology ; RNA, Circular/physiology ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
A transgenic system for targeted ablation of reproductive and maternal-effect genes.
Autorzy :
Bertho S; Department of Cell, Developmental and Regenerative Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1020 New York, NY 10029-6574, USA.
Kaufman O; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx NY 10461, USA.
Lee K; Department of Cell, Developmental and Regenerative Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1020 New York, NY 10029-6574, USA.
Santos-Ledo A; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx NY 10461, USA.
Dellal D; Department of Cell, Developmental and Regenerative Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1020 New York, NY 10029-6574, USA.
Marlow FL; Department of Cell, Developmental and Regenerative Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1020 New York, NY 10029-6574, USA.; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx NY 10461, USA.
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Źródło :
Development (Cambridge, England) [Development] 2021 Jun 15; Vol. 148 (12). Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Knockdown Techniques*
Gene Targeting*/methods
Maternal Inheritance*
Transgenes*
Embryonic Development/*genetics
Reproduction/*genetics
Animals ; Animals, Genetically Modified ; Gene Expression ; Genetic Vectors/genetics ; Germ Cells/metabolism ; Humans ; Mutagenesis ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Knockdown of Malat1 alleviates high-glucose-induced angiogenesis through regulating miR-205-5p/VEGF-A axis.
Autorzy :
Tan A; Department of Geriatric Medicine, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, Kunming, 650032, Yunnan, China. Electronic address: .
Li T; Department of Geriatric Medicine, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, Kunming, 650032, Yunnan, China. Electronic address: .
Ruan L; Department of Geriatric Medicine, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, Kunming, 650032, Yunnan, China. Electronic address: .
Yang J; Department of Geriatric Medicine, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, Kunming, 650032, Yunnan, China. Electronic address: .
Luo Y; Department of Geriatric Medicine, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, Kunming, 650032, Yunnan, China. Electronic address: .
Li L; Biomedical Engineering Research Center, Kunming Medical University, No. 1168 Chunrong West Road, Kunming, 650500, Yunnan, China. Electronic address: .
Wu X; The School of Public Health, Kunming Medical University, No. 1168 Chunrong West Road, Kunming, 650500, Yunnan, China. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2021 Jun; Vol. 207, pp. 108585. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockdown Techniques*
Diabetic Retinopathy/*prevention & control
Gene Expression Regulation/*physiology
Glucose/*pharmacology
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
Retinal Neovascularization/*prevention & control
Vascular Endothelial Growth Factor A/*genetics
Actins/metabolism ; Animals ; Antigens, CD/metabolism ; Blotting, Western ; Cadherins/metabolism ; Cells, Cultured ; Diabetic Retinopathy/genetics ; Diabetic Retinopathy/metabolism ; Disease Models, Animal ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Humans ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; Real-Time Polymerase Chain Reaction ; Retinal Neovascularization/genetics ; Retinal Neovascularization/metabolism ; Retinal Vessels/cytology ; S100 Calcium-Binding Protein A4/metabolism ; Transfection ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Hsa_circ_0032131 knockdown inhibits osteoarthritis progression via the miR-502-5p/PRDX3 axis.
Autorzy :
Xu J; Department of Pain Treatment, Tianjin Hospital, Tianjin 300211, China.
Ma X; Department of Pain Treatment, Tianjin Hospital, Tianjin 300211, China.
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Źródło :
Aging [Aging (Albany NY)] 2021 May 25; Vol. 13 (11), pp. 15100-15113. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockdown Techniques*
MicroRNAs/*metabolism
Osteoarthritis/*genetics
Osteoarthritis/*pathology
Peroxiredoxin III/*metabolism
RNA, Circular/*metabolism
Animals ; Apoptosis/genetics ; Base Sequence ; Cell Line ; Cell Proliferation/genetics ; Disease Progression ; Interleukin-1beta/metabolism ; MicroRNAs/genetics ; Models, Biological ; Peroxiredoxin III/genetics ; RNA, Circular/genetics ; RNA, Small Interfering/metabolism ; Rats, Wistar ; STAT3 Transcription Factor/metabolism ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł :
STAM2 knockdown inhibits proliferation, migration, and invasion by affecting the JAK2/STAT3 signaling pathway in gastric cancer.
Autorzy :
Yang Y; Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha 410001, China.
Zhang Q; Department of General Surgery, Clinical Medical College of Yangzhou University, Yangzhou 225001, China.
Liang J; Department of General Surgery, Clinical Medical College of Yangzhou University, Yangzhou 225001, China.
Yang M; Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha 410001, China.
Wang Z; Department of General Surgery, Clinical Medical College of Yangzhou University, Yangzhou 225001, China.
Tang D; Clinical Medical College of Yangzhou University, Northern Jiangsu Province Hospital, General Surgery Institute of Yangzhou, Yangzhou University, Yangzhou 225001, China.
Wang D; Clinical Medical College of Yangzhou University, Northern Jiangsu Province Hospital, General Surgery Institute of Yangzhou, Yangzhou University, Yangzhou 225001, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2021 May 21; Vol. 53 (6), pp. 697-706.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockdown Techniques*
Adaptor Proteins, Signal Transducing/*genetics
Adaptor Proteins, Signal Transducing/*metabolism
Cell Movement/*genetics
Cell Proliferation/*genetics
Endosomal Sorting Complexes Required for Transport/*genetics
Endosomal Sorting Complexes Required for Transport/*metabolism
Janus Kinase 2/*metabolism
STAT3 Transcription Factor/*metabolism
Signal Transduction/*genetics
Stomach Neoplasms/*metabolism
Stomach Neoplasms/*pathology
Aged ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Cycle/genetics ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Janus Kinase 2/genetics ; Male ; Middle Aged ; Neoplasm Invasiveness/genetics ; Prognosis ; STAT3 Transcription Factor/genetics ; Stomach Neoplasms/surgery ; Transfection ; Up-Regulation
Czasopismo naukowe
Tytuł :
Redd1 knockdown prevents doxorubicin-induced cardiac senescence.
Autorzy :
Huang P; Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.; Department of Geriatrics, Wuhan No.1 Hospital, Wuhan, Hubei 430022, China.
Bai L; Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Liu L; Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Fu J; Department of Radiology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, China.
Wu K; Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Liu H; Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Liu Y; Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Qi B; Department of Otorhinolaryngology, First People's Hospital of Yunnan Province, Kunming, Yunnan 650000, China.
Qi B; Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
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Źródło :
Aging [Aging (Albany NY)] 2021 May 06; Vol. 13 (10), pp. 13788-13806. Date of Electronic Publication: 2021 May 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Gene Knockdown Techniques*
Doxorubicin/*adverse effects
Myocardium/*metabolism
Myocardium/*pathology
Transcription Factors/*genetics
Aging/metabolism ; Animals ; Cell Line ; Cells, Cultured ; MAP Kinase Signaling System/drug effects ; Male ; Mice, Inbred C57BL ; Mutation/genetics ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; NF-kappa B/metabolism ; Rats ; Transcription Factors/metabolism ; Up-Regulation/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Fndc5 knockdown significantly decreased the expression of neurotrophins and their respective receptors during neural differentiation of mouse embryonic stem cells.
Autorzy :
Ebadi R; Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
Rabiee F; Department of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, 816513-1378, Isfahan, Iran.
Kordi-Tamandani D; Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
Nasr-Esfahani MH; Department of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, 816513-1378, Isfahan, Iran. .
Ghaedi K; Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Hezar Jerib Ave, Azadi Square, 81746, Isfahan, Iran. .
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Źródło :
Human cell [Hum Cell] 2021 May; Vol. 34 (3), pp. 847-861. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockdown Techniques*
Cell Differentiation/*genetics
Fibronectins/*physiology
Gene Expression/*genetics
Mouse Embryonic Stem Cells/*physiology
Nerve Growth Factors/*genetics
Nerve Growth Factors/*metabolism
Neurogenesis/*genetics
Receptors, Nerve Growth Factor/*genetics
Receptors, Nerve Growth Factor/*metabolism
Animals ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Cells, Cultured ; Mice ; Nerve Growth Factor/genetics ; Nerve Growth Factor/metabolism
Czasopismo naukowe
Tytuł :
Knockdown of RRM1 with Adenoviral shRNA Vectors to Inhibit Tumor Cell Viability and Increase Chemotherapeutic Sensitivity to Gemcitabine in Bladder Cancer Cells.
Autorzy :
Zhang X; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Taoka R; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Liu D; Department of General Thoracic Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Matsuoka Y; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Tohi Y; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Kakehi Y; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Sugimoto M; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 15; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockdown Techniques*
Adenoviridae/*genetics
Deoxycytidine/*analogs & derivatives
Genetic Vectors/*metabolism
RNA, Small Interfering/*metabolism
Ribonucleoside Diphosphate Reductase/*metabolism
Urinary Bladder Neoplasms/*drug therapy
Urinary Bladder Neoplasms/*pathology
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Deoxycytidine/pharmacology ; Deoxycytidine/therapeutic use ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Ribonucleoside Diphosphate Reductase/genetics ; Urinary Bladder Neoplasms/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Knock-down of LRP/LR influences signalling pathways in late-stage colorectal carcinoma cells.
Autorzy :
Vania L; School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa.
Morris G; School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa.
Ferreira E; School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa.
Weiss SFT; School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Apr 09; Vol. 21 (1), pp. 392. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockdown Techniques*
Signal Transduction*
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*metabolism
Receptors, Laminin/*genetics
Receptors, Laminin/*metabolism
Apoptosis/genetics ; Cell Line, Tumor ; Cell Survival/genetics ; Colorectal Neoplasms/pathology ; Gene Expression Profiling ; Humans ; Neoplasm Staging ; Proteome ; Proteomics/methods ; RNA, Small Interfering/genetics ; Telomerase/metabolism ; Transcriptome ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Hepatic Scavenger Receptor Class B Type 1 Knockdown Reduces Atherosclerosis and Enhances the Antiatherosclerotic Effect of Brown Fat Activation in APOE*3-Leiden.CETP Mice.
Autorzy :
Zhou E; Division of Endocrinology, Department of Medicine, Einthoven Laboratory for Experimental Vascular Medicine (E.Z., Z.L., H.N., C.L., Z.Y., J.F.P.B., KW.v.D., P.C.N.R., Y.W.), Leiden University Medical Center, The Netherlands.
Li Z; Division of Endocrinology, Department of Medicine, Einthoven Laboratory for Experimental Vascular Medicine (E.Z., Z.L., H.N., C.L., Z.Y., J.F.P.B., KW.v.D., P.C.N.R., Y.W.), Leiden University Medical Center, The Netherlands.
Nakashima H; Division of Endocrinology, Department of Medicine, Einthoven Laboratory for Experimental Vascular Medicine (E.Z., Z.L., H.N., C.L., Z.Y., J.F.P.B., KW.v.D., P.C.N.R., Y.W.), Leiden University Medical Center, The Netherlands.
Liu C; Division of Endocrinology, Department of Medicine, Einthoven Laboratory for Experimental Vascular Medicine (E.Z., Z.L., H.N., C.L., Z.Y., J.F.P.B., KW.v.D., P.C.N.R., Y.W.), Leiden University Medical Center, The Netherlands.
Ying Z; Division of Endocrinology, Department of Medicine, Einthoven Laboratory for Experimental Vascular Medicine (E.Z., Z.L., H.N., C.L., Z.Y., J.F.P.B., KW.v.D., P.C.N.R., Y.W.), Leiden University Medical Center, The Netherlands.
Foks AC; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, The Netherlands (A.C.F.).
Berbée JFP; Division of Endocrinology, Department of Medicine, Einthoven Laboratory for Experimental Vascular Medicine (E.Z., Z.L., H.N., C.L., Z.Y., J.F.P.B., KW.v.D., P.C.N.R., Y.W.), Leiden University Medical Center, The Netherlands.
van Dijk KW; Division of Endocrinology, Department of Medicine, Einthoven Laboratory for Experimental Vascular Medicine (E.Z., Z.L., H.N., C.L., Z.Y., J.F.P.B., KW.v.D., P.C.N.R., Y.W.), Leiden University Medical Center, The Netherlands.; Department of Human Genetics (K.W.v.D.), Leiden University Medical Center, The Netherlands.
Rensen PCN; Division of Endocrinology, Department of Medicine, Einthoven Laboratory for Experimental Vascular Medicine (E.Z., Z.L., H.N., C.L., Z.Y., J.F.P.B., KW.v.D., P.C.N.R., Y.W.), Leiden University Medical Center, The Netherlands.; Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University, China (P.C.N.R., Y.W.).
Wang Y; Division of Endocrinology, Department of Medicine, Einthoven Laboratory for Experimental Vascular Medicine (E.Z., Z.L., H.N., C.L., Z.Y., J.F.P.B., KW.v.D., P.C.N.R., Y.W.), Leiden University Medical Center, The Netherlands.; Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University, China (P.C.N.R., Y.W.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Apr; Vol. 41 (4), pp. 1474-1486. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockdown Techniques*
Adipose Tissue, Brown/*metabolism
Adrenergic beta-3 Receptor Agonists/*pharmacology
Apolipoprotein E3/*metabolism
Atherosclerosis/*prevention & control
Cholesterol Ester Transfer Proteins/*metabolism
Dioxoles/*pharmacology
Lipids/*blood
Liver/*metabolism
Scavenger Receptors, Class B/*deficiency
Adipose Tissue, Brown/drug effects ; Animals ; Apolipoprotein E3/genetics ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Biomarkers/blood ; Cholesterol Ester Transfer Proteins/genetics ; Disease Models, Animal ; Humans ; Lipolysis/drug effects ; Mice, Inbred C57BL ; Mice, Transgenic ; Plaque, Atherosclerotic ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Scavenger Receptors, Class B/genetics
Czasopismo naukowe
Tytuł :
Enhanced gemcitabine cytotoxicity with knockdown of multidrug resistance protein genes in human cholangiocarcinoma cell lines.
Autorzy :
Yang J; Section of Hepatology, College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Sontag D; Section of Hepatology, College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Gong Y; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Minuk GY; Section of Hepatology, College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
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Źródło :
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2021 Apr; Vol. 36 (4), pp. 1103-1109. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockdown Techniques*/methods
ATP Binding Cassette Transporter, Subfamily B/*genetics
Antimetabolites, Antineoplastic/*toxicity
Cholangiocarcinoma/*genetics
Cholangiocarcinoma/*pathology
Deoxycytidine/*analogs & derivatives
Drug Resistance, Neoplasm/*genetics
Gene Expression/*drug effects
Liver Neoplasms/*genetics
Liver Neoplasms/*pathology
ATP Binding Cassette Transporter, Subfamily B/metabolism ; Cell Line, Tumor ; Deoxycytidine/toxicity ; Humans ; Liver/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe

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