Temat: "Gene Knockdown Techniques" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance.
Autorzy:: Pucci G; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCeF), University of Palermo, Viale delle Scienze Bld.17, 90128 Palermo, Italy.
Minafra L; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCeF), University of Palermo, Viale delle Scienze Bld.17, 90128 Palermo, Italy.
Bravatà V; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.
Calvaruso M; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.
Turturici G; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCeF), University of Palermo, Viale delle Scienze Bld.17, 90128 Palermo, Italy.
Cammarata FP; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.
Savoca G; Radiation Oncology, ARNAS-Civico Hospital, 90100 Palermo, Italy.
Abbate B; Radiation Oncology, ARNAS-Civico Hospital, 90100 Palermo, Italy.
Russo G; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.
Cavalieri V; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCeF), University of Palermo, Viale delle Scienze Bld.17, 90128 Palermo, Italy.
Forte GI; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCeF), University of Palermo, Viale delle Scienze Bld.17, 90128 Palermo, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 08; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:: Journal Article
MeSH Terms:: Glioblastoma*/genetics
Glioblastoma*/radiotherapy
Glioblastoma*/metabolism
Glucose Transporter Type 3*/genetics
Glucose Transporter Type 3*/metabolism
Humans ; Biomarkers/metabolism ; Cell Hypoxia/genetics ; Cell Line, Tumor ; Gene Knockdown Techniques ; Hypoxia

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Skocz do pozycji: 2.

Tytuł:: Transcriptional Regulation Technology for Gene Perturbation in Fission Yeast.
Autorzy:: Ishikawa K; Department of Cell Biology, Institute of Life Science, Kurume University, Asahi-machi 67, Fukuoka 830-0011, Japan.
Saitoh S; Department of Cell Biology, Institute of Life Science, Kurume University, Asahi-machi 67, Fukuoka 830-0011, Japan.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2023 Apr 21; Vol. 13 (4). Date of Electronic Publication: 2023 Apr 21.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Transcription, Genetic*
Schizosaccharomyces*/genetics
Gene Editing*/methods
CRISPR-Cas Systems*
Gene Knockdown Techniques*
Gene Expression Regulation, Fungal ; Mutation ; Genome-Wide Association Study

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Skocz do pozycji: 3.

Tytuł:: Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology.
Autorzy:: Lee JS; Research Center for CFS/ME, Daejeon Hospital of Daejeon University, Daejeon, Republic of Korea.; Institute of Bioscience & Integrative Medicine, Daejeon University, Daejeon, Republic of Korea.
Kang JY; Institute of Bioscience & Integrative Medicine, Daejeon University, Daejeon, Republic of Korea.
Park SY; Korean Medical College of Daejeon University, Daejeon, Republic of Korea.
Hwang SJ; Institute of Bioscience & Integrative Medicine, Daejeon University, Daejeon, Republic of Korea.
Bae SJ; College of Medicine, Kosin University, Busan, Republic of Korea.
Son CG; Research Center for CFS/ME, Daejeon Hospital of Daejeon University, Daejeon, Republic of Korea. .; Institute of Bioscience & Integrative Medicine, Daejeon University, Daejeon, Republic of Korea. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2024 Jan 08; Vol. 22 (1), pp. 34. Date of Electronic Publication: 2024 Jan 08.
Typ publikacji:: Journal Article
MeSH Terms:: Fatigue Syndrome, Chronic*
Animals ; Mice ; Serotonin ; Disease Models, Animal ; Gene Knockdown Techniques ; Hypothalamo-Hypophyseal System

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Skocz do pozycji: 4.

Tytuł:: An AMPK agonist suppresses the progress of colorectal cancer by regulating the polarization of TAM to M1 through inhibition of HIF-1α and mTOR signal pathway.
Autorzy:: Cao Y; Department of Laboratory Medicine, Hangzhou Cancer Hospital, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Shangcheng, China.
Wo M; Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Zhejiang Center for Clinical Laboratory, Gongshu, China.
Xu C; Department of Laboratory Medicine, Affiliated Third Hospital of Zhejiang Traditional Chinese Medicine University, Xihu, Hangzhou, Zhejiang, China.
Fei X; Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Zhejiang Center for Clinical Laboratory, Gongshu, China.
Jin J; Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Zhejiang Center for Clinical Laboratory, Gongshu, China.
Shan Z; Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Zhejiang Center for Clinical Laboratory, Gongshu, China.; Pokaż więcej
Źródło:: Journal of cancer research and therapeutics [J Cancer Res Ther] 2023 Dec 01; Vol. 19 (6), pp. 1560-1567. Date of Electronic Publication: 2023 Dec 28.
Typ publikacji:: Journal Article
MeSH Terms:: Metformin*/pharmacology
Metformin*/therapeutic use
Signal Transduction*/drug effects
TOR Serine-Threonine Kinases*/antagonists & inhibitors
TOR Serine-Threonine Kinases*/metabolism
Colorectal Neoplasms*/drug therapy
Tumor-Associated Macrophages*/drug effects
Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; HCT116 Cells ; Cell Polarity/drug effects ; THP-1 Cells ; AMP-Activated Protein Kinases/antagonists & inhibitors ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Gene Knockdown Techniques

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Skocz do pozycji: 5.

Tytuł:: Optimal combination of cationic lipid and phospholipid in cationic liposomes for gene knockdown in breast cancer cells and mouse lung using siRNA lipoplexes.
Autorzy:: Hattori Y; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Tang M; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Torii S; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Tomita K; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Sagawa A; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Inoue N; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Yamagishi R; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Ozaki KI; Department of Molecular Pathology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto 610-0395, Japan.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2022 Aug; Vol. 26 (2). Date of Electronic Publication: 2022 Jun 10.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Knockdown Techniques*
Liposomes*
Animals ; Cations ; Female ; Humans ; Luciferases ; Lung ; MCF-7 Cells ; Mice ; Phosphatidylcholines ; Phosphatidylethanolamines ; Phospholipids ; RNA, Small Interfering/genetics ; Transfection

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Skocz do pozycji: 6.

Tytuł:: Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice.
Autorzy:: Arullampalam P; Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland.
Essers MC; Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland.
Boukenna M; Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland.
Guichard S; Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland.
Rougier JS; Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland.
Abriel H; Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland.; Pokaż więcej
Źródło:: Physiological reports [Physiol Rep] 2023 Aug; Vol. 11 (16), pp. e15783.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Electrophysiologic Techniques, Cardiac*
TRPM Cation Channels*/genetics
Animals ; Female ; Male ; Mice ; Cardiac Electrophysiology ; Electrocardiography ; Hemodynamics ; Myocytes, Cardiac ; Gene Knockdown Techniques

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Skocz do pozycji: 7.

Tytuł:: Knockdown of lysyl oxidase like 1 inhibits the proliferation and pro-fibrotic effects of transforming growth factor-β1-induced hypertrophic scar fibroblasts.
Autorzy:: Ying M; Department of Dermatology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo City, Zhejiang Province 315020, China.
Chen Y; Department of Dermatology, Ningbo Medical Center Lihuili Hospital, Ningbo City, Zhejiang Province 315040, China.
Yuan B; Department of Dermatology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo City, Zhejiang Province 315020, China.; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2021 Dec; Vol. 99 (12), pp. 1272-1279. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Knockdown Techniques*
Gene Silencing*
Amino Acid Oxidoreductases/*genetics
Amino Acid Oxidoreductases/*physiology
Cell Proliferation/*genetics
Fibroblasts/*pathology
Fibrosis/*genetics
Signal Transduction/*genetics
Signal Transduction/*physiology
Transforming Growth Factor beta1/*physiology
Adult ; Cell Movement/genetics ; Extracellular Matrix/metabolism ; Female ; Humans ; Male ; Middle Aged ; Phosphorylation ; Smad2 Protein/metabolism ; Smad3 Protein/metabolism ; Wound Healing/genetics ; Wound Healing/physiology

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Skocz do pozycji: 8.

Tytuł:: Enduring Effects of Conditional Brain Serotonin Knockdown, Followed by Recovery, on Adult Rat Neurogenesis and Behavior.
Autorzy:: Sidorova M; School of Life Sciences, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia.; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
Kronenberg G; Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatrische Universitätsklinik, 8032 Zürich, Switzerland.; Department of Psychiatry and Psychotherapy, Charité University Medicine, 10117 Berlin, Germany.
Matthes S; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
Petermann M; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.; Department of Clinical Pharmacy and Pharmacotherapy, Institute of Pharmacy, Martin Luther University, 06120 Halle, Germany.
Hellweg R; Department of Psychiatry and Psychotherapy, Charité University Medicine, 10117 Berlin, Germany.
Tuchina O; School of Life Sciences, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia.
Bader M; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
Alenina N; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.; Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia.
Klempin F; School of Life Sciences, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia.; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité University Medicine, 10117 Berlin, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Nov 19; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Behavior, Animal*
Gene Knockdown Techniques*
Neurogenesis*
Aging/*physiology
Serotonin/*metabolism
Animals ; Cell Count ; Cell Proliferation ; Dentate Gyrus/cytology ; Female ; Phenotype ; Prefrontal Cortex/metabolism ; Raphe Nuclei/metabolism ; Rats, Sprague-Dawley ; Tryptophan Hydroxylase/metabolism ; Rats

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Skocz do pozycji: 9.

Tytuł:: Preventing adolescent synaptic pruning in mouse prelimbic cortex via local knockdown of α4βδ GABA A receptors increases anxiety response in adulthood.
Autorzy:: Evrard MR; Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA.; Graduate Program in Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA.
Li M; Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA.; College of Arts and Sciences, Hunter College, New York, NY, 10065, USA.
Shen H; Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA.; School of Biomedical Engineering, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, 300070, China.
Smith SS; Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Oct 26; Vol. 11 (1), pp. 21059. Date of Electronic Publication: 2021 Oct 26.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Anxiety*/genetics
Anxiety*/metabolism
Gene Knockdown Techniques*
Neuronal Plasticity*
Sexual Maturation*
Brain/*metabolism
Receptors, GABA-A/*deficiency
Animals ; Female ; Male ; Mice ; Mice, Knockout ; Receptors, GABA-A/metabolism

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Skocz do pozycji: 10.

Tytuł:: The choice of negative control antisense oligonucleotides dramatically impacts downstream analysis depending on the cellular background.
Autorzy:: Ducoli L; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.; Molecular Life Sciences PhD Program, Swiss Federal Institute of Technology and University of Zurich, Zurich, Switzerland.
Agrawal S; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
Hon CC; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
Ramilowski JA; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
Sibler E; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.; Molecular Life Sciences PhD Program, Swiss Federal Institute of Technology and University of Zurich, Zurich, Switzerland.
Tagami M; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
Itoh M; RIKEN Preventive Medicine and Diagnosis Innovation Program, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
Kondo N; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
Abugessaisa I; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
Hasegawa A; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
Kasukawa T; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
Suzuki H; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
Carninci P; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.; Human Technopole, Via Cristina Belgioioso 171, 20157, Milan, Italy.
Shin JW; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
de Hoon MJL; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.; RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.
Detmar M; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland. .; Pokaż więcej
Źródło:: BMC genomic data [BMC Genom Data] 2021 Sep 14; Vol. 22 (1), pp. 33. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Knockdown Techniques/*methods
Oligonucleotides, Antisense/*genetics
Organ Specificity/*genetics
RNA, Long Noncoding/*genetics
Adult ; Endothelial Cells/metabolism ; Gene Knockdown Techniques/standards ; Humans ; Lymphatic System/cytology ; Lymphatic System/metabolism ; Oligonucleotides, Antisense/standards ; Transcriptome

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Skocz do pozycji: 11.

Tytuł:: EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Autorzy:: Cai Y; Jiangsu Livestock Embryo Engineering Laboratory, Nanjing Agricultural University, Nanjing 210095, China.
Chen P; Jiangsu Livestock Embryo Engineering Laboratory, Nanjing Agricultural University, Nanjing 210095, China.
Xu H; Jiangsu Livestock Embryo Engineering Laboratory, Nanjing Agricultural University, Nanjing 210095, China.
Li S; Jiangsu Livestock Embryo Engineering Laboratory, Nanjing Agricultural University, Nanjing 210095, China.
Zhao B; Jiangsu Livestock Embryo Engineering Laboratory, Nanjing Agricultural University, Nanjing 210095, China.
Fan Y; Jiangsu Livestock Embryo Engineering Laboratory, Nanjing Agricultural University, Nanjing 210095, China.
Wang F; Jiangsu Livestock Embryo Engineering Laboratory, Nanjing Agricultural University, Nanjing 210095, China.
Zhang Y; Jiangsu Livestock Embryo Engineering Laboratory, Nanjing Agricultural University, Nanjing 210095, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 26; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 26.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/genetics
Signal Transduction*/physiology
Animals ; Sheep/genetics ; Gene Knockdown Techniques ; Follicle Stimulating Hormone, beta Subunit/genetics ; Cell Proliferation/genetics ; Mammals/genetics

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Skocz do pozycji: 12.

Tytuł:: LncRNA-PVT1 was identified as a key regulator for TMZ resistance and STAT-related pathway in glioma.
Autorzy:: Chen Y; Department of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, No.7 WeiWu Street, 450003, Zhengzhou, Zhengzhou, China.
Ma F; Department of Intensive Care Unit, The Third People's Hospital of Zhengzhou, Zhengzhou, China.
Zhang Z; Department of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, No.7 WeiWu Street, 450003, Zhengzhou, Zhengzhou, China.
Guo Y; Department of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, No.7 WeiWu Street, 450003, Zhengzhou, Zhengzhou, China.
Shen H; Department of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, No.7 WeiWu Street, 450003, Zhengzhou, Zhengzhou, China.
Chen H; Department of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, No.7 WeiWu Street, 450003, Zhengzhou, Zhengzhou, China. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2023 May 18; Vol. 23 (1), pp. 455. Date of Electronic Publication: 2023 May 18.
Typ publikacji:: Journal Article
MeSH Terms:: RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Temozolomide*/pharmacology
Temozolomide*/therapeutic use
Drug Resistance, Neoplasm*/genetics
Gene Expression Regulation, Neoplastic*/genetics
Glioma*/drug therapy
Glioma*/genetics
Glioma*/physiopathology
Gene Knockdown Techniques ; Carcinogenesis/genetics ; Survival Analysis ; STAT Transcription Factors/metabolism ; Janus Kinases/metabolism ; Cell Line, Tumor ; Humans ; Male ; Female ; Adult ; Middle Aged ; Biomarkers, Tumor/metabolism

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Skocz do pozycji: 13.

Tytuł:: Sulfotransferase 1C2 promotes hepatocellular carcinoma progression by enhancing glycolysis and fatty acid metabolism.
Autorzy:: Jiang L; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Xu F; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Li C; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Liu T; BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Zhao Q; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.; Henan Key Laboratory of Tumor Epidemiology and State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China.
Liu Y; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Zhao Y; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Li Y; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Zhang Z; BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Tang X; Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, New York, USA.; Division of Regenerative Medicine, Department of Medicine, Department of Basic Science, School of Medicine, Loma Linda University, Loma Linda, California, USA.
Zhang J; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.; Henan Key Laboratory of Tumor Epidemiology and State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2023 May; Vol. 12 (9), pp. 10738-10754. Date of Electronic Publication: 2023 Mar 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Liver Neoplasms*/metabolism
Liver Neoplasms*/pathology
Carcinoma, Hepatocellular*/metabolism
Carcinoma, Hepatocellular*/pathology
Sulfotransferases*/metabolism
Humans ; Mice ; Glycolysis ; Fatty Acids/metabolism ; Cell Line, Tumor ; Metabolomics ; Mice, Inbred BALB C ; Gene Knockdown Techniques ; Cell Movement ; Neoplasm Invasiveness ; Gene Expression ; Animals

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Skocz do pozycji: 14.

Tytuł:: Divalent Metal Transporter 1 Knock-Down Modulates IL-1β Mediated Pancreatic Beta-Cell Pro-Apoptotic Signaling Pathways through the Autophagic Machinery.
Autorzy:: Kang T; Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.; The Danish Diabetes Academy, 5230 Odense M, Denmark.
Huang H; Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Mandrup-Poulsen T; Immuno-Endocrinology Laboratory, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
Larsen MR; Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jul 27; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 27.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Knockdown Techniques*
Apoptosis/*immunology
Autophagy/*immunology
Cation Transport Proteins/*deficiency
Insulin-Secreting Cells/*immunology
Interleukin-1beta/*immunology
Interleukin-6/*immunology
Signal Transduction/*immunology
Animals ; Apoptosis/genetics ; Autophagy/genetics ; Cation Transport Proteins/immunology ; Interleukin-1beta/genetics ; Interleukin-6/genetics ; Mice ; Signal Transduction/genetics

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Skocz do pozycji: 15.

Tytuł:: Knockdown of PEX16 Induces Autophagic Degradation of Peroxisomes.
Autorzy:: Wei X; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Maharjan Y; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Dorotea D; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Dutta RK; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kim D; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kim H; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Mu Y; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Park C; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Park R; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jul 26; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 26.
Typ publikacji:: Journal Article
MeSH Terms:: Autophagy*
Gene Knockdown Techniques*
Membrane Proteins/*deficiency
Peroxisomes/*metabolism
Retinal Pigment Epithelium/*metabolism
ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Cell Line ; Humans ; Membrane Proteins/metabolism ; Peroxisomes/genetics

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Skocz do pozycji: 16.

Tytuł:: SEMA4D Knockdown Attenuates β -Catenin-Dependent Tumor Progression in Colorectal Cancer.
Autorzy:: Rezaeepoor M; Department of Immunology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Rashidi G; Department of Immunology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Pourjafar M; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Mohammadi C; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Solgi G; Department of Immunology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Najafi R; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.; Pokaż więcej
Źródło:: BioMed research international [Biomed Res Int] 2021 Jul 21; Vol. 2021, pp. 8507373. Date of Electronic Publication: 2021 Jul 21 (Print Publication: 2021).
Typ publikacji:: Journal Article
MeSH Terms:: Disease Progression*
Gene Knockdown Techniques*
Antigens, CD/*metabolism
Colorectal Neoplasms/*metabolism
Colorectal Neoplasms/*pathology
Semaphorins/*metabolism
beta Catenin/*metabolism
Antigens, CD/genetics ; Apoptosis ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Survival ; Colorectal Neoplasms/genetics ; Down-Regulation ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; RNA, Small Interfering/metabolism ; Semaphorins/genetics

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Skocz do pozycji: 17.

Tytuł:: Circ-SPG11 knockdown hampers IL-1β-induced osteoarthritis progression via targeting miR-337-3p/ADAMTS5.
Autorzy:: Liu Y; Department of Orthopedics, Shijiazhuang People's Hospital, No. 365 Jianhua South Road, Shijiazhang, Hebei, 050000, People's Republic of China.
Li Q; Department of Orthopedics, Shijiazhuang People's Hospital, No. 365 Jianhua South Road, Shijiazhang, Hebei, 050000, People's Republic of China.
Gao Z; Department of Orthopedics, Shijiazhuang People's Hospital, No. 365 Jianhua South Road, Shijiazhang, Hebei, 050000, People's Republic of China.
Lei F; Department of Orthopedics, Shijiazhuang People's Hospital, No. 365 Jianhua South Road, Shijiazhang, Hebei, 050000, People's Republic of China. .
Gao X; Department of Orthopedics, Shijiazhuang People's Hospital, No. 365 Jianhua South Road, Shijiazhang, Hebei, 050000, People's Republic of China.; Pokaż więcej
Źródło:: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2021 Jun 17; Vol. 16 (1), pp. 392. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Knockdown Techniques*
ADAMTS5 Protein/*genetics
ADAMTS5 Protein/*metabolism
Interleukin-1beta/*adverse effects
MicroRNAs/*genetics
MicroRNAs/*metabolism
Osteoarthritis, Knee/*genetics
Proteins/*genetics
RNA, Circular/*genetics
Cell Line ; Disease Progression ; Down-Regulation/genetics ; Gene Expression Regulation/genetics ; Humans ; Osteoarthritis, Knee/etiology ; Proteins/physiology ; RNA, Circular/physiology ; Up-Regulation/genetics

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Skocz do pozycji: 18.

Tytuł:: Knockdown of RRM1 with Adenoviral shRNA Vectors to Inhibit Tumor Cell Viability and Increase Chemotherapeutic Sensitivity to Gemcitabine in Bladder Cancer Cells.
Autorzy:: Zhang X; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Taoka R; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Liu D; Department of General Thoracic Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Matsuoka Y; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Tohi Y; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Kakehi Y; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Sugimoto M; Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Apr 15; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 15.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Knockdown Techniques*
Adenoviridae/*genetics
Deoxycytidine/*analogs & derivatives
Genetic Vectors/*metabolism
RNA, Small Interfering/*metabolism
Ribonucleoside Diphosphate Reductase/*metabolism
Urinary Bladder Neoplasms/*drug therapy
Urinary Bladder Neoplasms/*pathology
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Deoxycytidine/pharmacology ; Deoxycytidine/therapeutic use ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Ribonucleoside Diphosphate Reductase/genetics ; Urinary Bladder Neoplasms/genetics ; Xenograft Model Antitumor Assays ; Gemcitabine ; Mice

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Skocz do pozycji: 19.

Tytuł:: Knock-down of LRP/LR influences signalling pathways in late-stage colorectal carcinoma cells.
Autorzy:: Vania L; School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa.
Morris G; School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa.
Ferreira E; School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa.
Weiss SFT; School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2021 Apr 09; Vol. 21 (1), pp. 392. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Knockdown Techniques*
Signal Transduction*
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*metabolism
Receptors, Laminin/*genetics
Receptors, Laminin/*metabolism
Apoptosis/genetics ; Cell Line, Tumor ; Cell Survival/genetics ; Colorectal Neoplasms/pathology ; Gene Expression Profiling ; Humans ; Neoplasm Staging ; Proteome ; Proteomics/methods ; RNA, Small Interfering/genetics ; Telomerase/metabolism ; Transcriptome ; Tumor Cells, Cultured

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Skocz do pozycji: 20.

Tytuł:: P25 Gene Knockout Contributes to Human Epidermal Growth Factor Production in Transgenic Silkworms.
Autorzy:: Wu M; College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Ruan J; College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Ye X; College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Zhao S; College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Tang X; College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Wang X; College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Li H; College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Zhong B; College of Animal Science, Zhejiang University, Hangzhou 310058, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 08; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 08.
Typ publikacji:: Journal Article
MeSH Terms:: Animals, Genetically Modified*/genetics
Animals, Genetically Modified*/metabolism
Bombyx*/genetics
Bombyx*/metabolism
Epidermal Growth Factor*/biosynthesis
Epidermal Growth Factor*/genetics
Gene Knockdown Techniques*
Fibroins/*genetics
Animals ; Humans ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism

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