Temat: "Gene Knockout Techniques" - OpacWWW

Skocz do pozycji: 41.

Tytuł:: A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death.
Autorzy:: Gomes GM; Research Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118, Magdeburg, Germany.; Center for Behavioral Brain Sciences, Otto-Von-Guericke University, Magdeburg, Germany.
Bär J; Research Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118, Magdeburg, Germany.; Research Group Optobiology, Institute of Biology, HU Berlin, 10115, Berlin, Germany.
Karpova A; Research Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118, Magdeburg, Germany.; Center for Behavioral Brain Sciences, Otto-Von-Guericke University, Magdeburg, Germany.
Kreutz MR; Research Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118, Magdeburg, Germany. .; Center for Behavioral Brain Sciences, Otto-Von-Guericke University, Magdeburg, Germany. .; Leibniz Group 'Dendritic Organelles and Synaptic Function', University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology, ZMNH, Hamburg, Germany. .; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. .; Pokaż więcej
Źródło:: Molecular brain [Mol Brain] 2023 Feb 11; Vol. 16 (1), pp. 23. Date of Electronic Publication: 2023 Feb 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Death*
Hypoxia*/metabolism
N-Methylaspartate*/toxicity
Neurons*/metabolism
Nerve Tissue Proteins*/genetics
Animals ; Mice ; Gene Knockout Techniques ; Glucose ; Oxygen ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/metabolism ; Transcription Factors/metabolism

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Skocz do pozycji: 42.

Tytuł:: PARP1 Gene Knockout Suppresses Expression of DNA Base Excision Repair Genes.
Autorzy:: Zakharenko AL; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Malakhova AA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.; Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, Novosibirsk, Russia.
Dyrkheeva NS; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Okorokova LS; AcademGene LLC, Novosibirsk, Russia.
Medvedev SP; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.; Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, Novosibirsk, Russia.
Zakian SM; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.; Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, Novosibirsk, Russia.
Kabilov MR; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Tupikin AA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Lavrik OI; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. .; Pokaż więcej
Źródło:: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2023 Feb; Vol. 508 (1), pp. 6-11. Date of Electronic Publication: 2023 Jan 18.
Typ publikacji:: Journal Article
MeSH Terms:: Poly(ADP-ribose) Polymerases*/genetics
DNA Glycosylases*/genetics
DNA Glycosylases*/metabolism
Humans ; HEK293 Cells ; Gene Knockout Techniques ; DNA Repair ; DNA ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism

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Skocz do pozycji: 43.

Tytuł:: Dimmed gene knockout shortens larval growth and reduces silk yield in the silkworm, Bombyx mori.
Autorzy:: Cao J; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Zheng HS; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Zhang R; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Xu YP; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Pan H; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Li S; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Liu C; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.; Cancer Center, Medical Research Institute, Southwest University, Chongqing, China.
Cheng TC; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.; Cancer Center, Medical Research Institute, Southwest University, Chongqing, China.; Pokaż więcej
Źródło:: Insect molecular biology [Insect Mol Biol] 2023 Feb; Vol. 32 (1), pp. 26-35. Date of Electronic Publication: 2022 Sep 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Bombyx*/genetics
Bombyx*/metabolism
Fibroins*/genetics
Animals ; Silk/genetics ; Larva/genetics ; Larva/metabolism ; Gene Knockout Techniques ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Insect Proteins/genetics ; Insect Proteins/metabolism

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Skocz do pozycji: 44.

Tytuł:: Combination gene therapy for HIV using a conditional suicidal gene with CCR5 knockout.
Autorzy:: Mehmetoglu-Gurbuz T; Department of Molecular and Translational Medicine, Center of Emphasis in Infectious Diseases, Texas Tech University Health Sciences Center, 5001 El Paso Dr, El Paso, TX, 79905, USA.
Yeh R; Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.
Garg H; Department of Molecular and Translational Medicine, Center of Emphasis in Infectious Diseases, Texas Tech University Health Sciences Center, 5001 El Paso Dr, El Paso, TX, 79905, USA.
Joshi A; Department of Molecular and Translational Medicine, Center of Emphasis in Infectious Diseases, Texas Tech University Health Sciences Center, 5001 El Paso Dr, El Paso, TX, 79905, USA. .; Pokaż więcej
Źródło:: Virology journal [Virol J] 2021 Jan 30; Vol. 18 (1), pp. 31. Date of Electronic Publication: 2021 Jan 30.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Gene Knockout Techniques*
Genes, Transgenic, Suicide*
Genetic Therapy/*methods
HIV Infections/*therapy
Receptors, CCR5/*genetics
Clustered Regularly Interspaced Short Palindromic Repeats ; Gene Editing/methods ; HEK293 Cells ; Humans ; Transduction, Genetic

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Skocz do pozycji: 45.

Tytuł:: CRISPR/Cas9-mediated knockout of clinically relevant alloantigenes in human primary T cells.
Autorzy:: Kamali E; Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Rahbarizadeh F; Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. .
Hojati Z; Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran. .
Frödin M; Biotech Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Pokaż więcej
Źródło:: BMC biotechnology [BMC Biotechnol] 2021 Jan 29; Vol. 21 (1), pp. 9. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: CRISPR-Cas Systems*
Gene Knockout Techniques*
Isoantigens/*genetics
T-Lymphocytes/*metabolism
CD52 Antigen/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats ; Electroporation ; Gene Editing/methods ; Genomics ; HEK293 Cells ; Humans ; INDEL Mutation ; Plasmids

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Skocz do pozycji: 46.

Tytuł:: Exploring gene knockout strategies to identify potential drug targets using genome-scale metabolic models.
Autorzy:: Paul A; Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, India.
Anand R; Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, India.
Karmakar SP; Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, India.
Rawat S; Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, India.
Bairagi N; Centre for Mathematical Biology and Ecology, Department of Mathematics, Jadavpur University, Kolkata, 700032, India.
Chatterjee S; Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, India. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Jan 08; Vol. 11 (1), pp. 213. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Knockout Techniques*
Genomics*
Models, Biological*
Molecular Targeted Therapy*
Metabolism/*drug effects
Metabolism/*genetics
Cell Line ; Humans

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Skocz do pozycji: 47.

Tytuł:: Knockout of the Glucocorticoid Receptor Impairs Reproduction in Female Zebrafish.
Autorzy:: Maradonna F; Department of Life and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche snc, 60131 Ancona, Italy.; Biostructures and Biosystems National Institute-Interuniversity Consortium, Viale delle Medaglie d'Oro 305, 00136 Roma, Italy.
Gioacchini G; Department of Life and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche snc, 60131 Ancona, Italy.
Notarstefano V; Department of Life and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche snc, 60131 Ancona, Italy.
Fontana CM; Department of Biology, Università di Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.
Citton F; Department of Biology, Università di Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.
Dalla Valle L; Department of Biology, Università di Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.
Giorgini E; Department of Life and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche snc, 60131 Ancona, Italy.
Carnevali O; Department of Life and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche snc, 60131 Ancona, Italy.; Biostructures and Biosystems National Institute-Interuniversity Consortium, Viale delle Medaglie d'Oro 305, 00136 Roma, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Nov 28; Vol. 21 (23). Date of Electronic Publication: 2020 Nov 28.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Knockout Techniques*
Receptors, Glucocorticoid/*metabolism
Reproduction/*physiology
Zebrafish/*physiology
Animals ; Female ; Fertility ; Gene Expression Regulation ; Oocytes/metabolism ; Ovary/cytology ; Reproduction/genetics ; Zebrafish/genetics

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Skocz do pozycji: 48.

Tytuł:: Dedicated transcriptomics combined with power analysis lead to functional understanding of genes with weak phenotypic changes in knockout lines.
Autorzy:: Xie C; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Bekpen C; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Künzel S; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Keshavarz M; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Krebs-Wheaton R; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Skrabar N; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Ullrich KK; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Zhang W; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Tautz D; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2020 Nov 12; Vol. 16 (11), pp. e1008354. Date of Electronic Publication: 2020 Nov 12 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms:: Gene Knockout Techniques*
Gene Expression Profiling/*methods
Genetic Association Studies/*methods
Animals ; Behavior, Animal ; Computational Biology ; Extremities/anatomy & histology ; Female ; Gene Expression Profiling/statistics & numerical data ; Genetic Association Studies/statistics & numerical data ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Genetic ; Phenotype ; Proof of Concept Study ; RNA-Seq/statistics & numerical data ; Transcriptome

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Skocz do pozycji: 49.

Tytuł:: Selenoprotein F knockout leads to glucose and lipid metabolism disorders in mice.
Autorzy:: Zheng X; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Ren B; College of Life Sciences and Oceanography, Shenzhen Key Laboratory of Microbial Genetic Engineering, Shenzhen University, Shenzhen, 518060, Guangdong, China.
Li X; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Yan H; College of Life Science, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Xie Q; College of Life Science, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Liu H; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Zhou J; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China. .
Tian J; College of Life Sciences and Oceanography, Shenzhen Key Laboratory of Microbial Genetic Engineering, Shenzhen University, Shenzhen, 518060, Guangdong, China. .
Huang K; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China. .; Pokaż więcej
Źródło:: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2020 Oct; Vol. 25 (7), pp. 1009-1022. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Knockout Techniques*
Glucose/*metabolism
Lipid Metabolism/*genetics
Metabolic Diseases/*genetics
Animals ; Diet, High-Fat/adverse effects ; Metabolic Diseases/chemically induced ; Metabolic Diseases/metabolism ; Mice

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Skocz do pozycji: 50.

Tytuł:: TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells.
Autorzy:: Cambria E; Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland.
Arlt MJE; Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland.; Department of Orthopedics, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.
Wandel S; Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland.
Krupkova O; Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland.; Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.; Spine Surgery, University Hospital Basel, 4031 Basel, Switzerland.
Hitzl W; Research Office (Biostatistics), Paracelsus Medical University, 5020 Salzburg, Austria.; Department of Ophthalmology and Optometry, Paracelsus Medical University, 5020 Salzburg, Austria.; Research Program Experimental Ophthalmology and Glaucoma Research, Paracelsus Medical University, 5020 Salzburg, Austria.
Passini FS; Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland.; Department of Orthopedics, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.
Hausmann ON; Neuro- and Spine Center, Hirslanden Klinik St. Anna, 6006 Lucerne, Switzerland.; Medical Faculty, University of Bern, 3012 Bern, Switzerland.
Snedeker JG; Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland.; Department of Orthopedics, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.
Ferguson SJ; Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland.
Wuertz-Kozak K; Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland.; Department of Biomedical Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA.; Spine Center, Schön Klinik München Harlaching, Academic Teaching Hospital and Spine Research Institute of the Paracelsus Private Medical University Salzburg (Austria), 81547 Munich, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2020 Jul 21; Vol. 9 (7). Date of Electronic Publication: 2020 Jul 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Knockout Techniques*
Stress, Mechanical*
Annulus Fibrosus/*physiology
CRISPR-Associated Protein 9/*metabolism
CRISPR-Cas Systems/*genetics
TRPV Cation Channels/*antagonists & inhibitors
Adolescent ; Adult ; Aged ; Cells, Cultured ; Dinoprostone/metabolism ; Female ; Gene Expression Regulation ; Humans ; Inflammation Mediators/metabolism ; Interleukin-8/genetics ; Interleukin-8/metabolism ; Male ; Middle Aged ; Phosphorylation ; TRPV Cation Channels/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism

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Skocz do pozycji: 51.

Tytuł:: Sarm1 knockout protects against early but not late axonal degeneration in experimental allergic encephalomyelitis.
Autorzy:: Viar K; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Njoku D; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Secor McVoy J; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Oh U; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Jun 25; Vol. 15 (6), pp. e0235110. Date of Electronic Publication: 2020 Jun 25 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Armadillo Domain Proteins*/genetics
Armadillo Domain Proteins*/metabolism
Axons*/metabolism
Axons*/pathology
Cytoskeletal Proteins*/genetics
Cytoskeletal Proteins*/metabolism
Encephalomyelitis, Autoimmune, Experimental*/genetics
Encephalomyelitis, Autoimmune, Experimental*/metabolism
Encephalomyelitis, Autoimmune, Experimental*/pathology
Encephalomyelitis, Autoimmune, Experimental*/prevention & control
Gene Knockout Techniques*
Spinal Cord*/metabolism
Spinal Cord*/pathology
Animals ; Mice ; Mice, Knockout ; Time Factors

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Skocz do pozycji: 52.

Tytuł:: Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway.
Autorzy:: Li Y; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Huang B; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Yang H; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Kan S; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Yao Y; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Liu X; Central Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 264000, P.R. China.
Pu S; School of Life Sciences, Research Center for Biomedical Sciences, Guangxi Normal University, Guilin, 541004, P.R. China.
He G; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Khan TM; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Qi G; School of Basic Medical Science, Guilin Medical University, Guilin, 541004, P.R. China.
Zhou Z; School of Life Sciences, Research Center for Biomedical Sciences, Guangxi Normal University, Guilin, 541004, P.R. China.
Shu W; College of Biotechnology, Guilin Medical University, Guilin, 541004, P.R. China. .
Chen M; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jun 17; Vol. 10 (1), pp. 9868. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Knockout Techniques*
Up-Regulation*
Colitis/*genetics
Colitis/*pathology
Nerve Tissue Proteins/*deficiency
Nerve Tissue Proteins/*genetics
Signal Transduction/*genetics
Amino Acid Sequence ; Animals ; Cell Line ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Mice ; NF-KappaB Inhibitor alpha/metabolism ; NF-kappa B/metabolism ; Ribosomal Proteins/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination

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Skocz do pozycji: 53.

Tytuł:: stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae.
Autorzy:: Wasilewska I; International Institute of Molecular and Cell Biology, 4 Ks. Trojdena Street, 02-109 Warsaw, Poland.
Gupta RK; International Institute of Molecular and Cell Biology, 4 Ks. Trojdena Street, 02-109 Warsaw, Poland.
Wojtaś B; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.
Palchevska O; International Institute of Molecular and Cell Biology, 4 Ks. Trojdena Street, 02-109 Warsaw, Poland.
Kuźnicki J; International Institute of Molecular and Cell Biology, 4 Ks. Trojdena Street, 02-109 Warsaw, Poland.; Pokaż więcej
Źródło:: Cells [Cells] 2020 May 21; Vol. 9 (5). Date of Electronic Publication: 2020 May 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Knockout Techniques*
Calcium-Binding Proteins/*metabolism
Seizures/*metabolism
Zebrafish/*metabolism
Zebrafish Proteins/*metabolism
Amino Acid Sequence ; Animals ; Calcium-Binding Proteins/chemistry ; Calcium-Binding Proteins/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Developmental/radiation effects ; Glutamic Acid/metabolism ; Larva/radiation effects ; Light Signal Transduction/radiation effects ; Mutation/genetics ; Neurons/metabolism ; Phenotype ; Phototaxis/radiation effects ; Zebrafish/genetics ; Zebrafish Proteins/chemistry ; Zebrafish Proteins/genetics ; gamma-Aminobutyric Acid/metabolism

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Skocz do pozycji: 54.

Tytuł:: Marker enzyme activities in hindleg from creatine-deficient AGAT and GAMT KO mice - differences between models, muscles, and sexes.
Autorzy:: Barsunova K; Laboratory of Systems Biology, Department of Cybernetics, Tallinn University of Technology, Tallinn, Estonia.
Vendelin M; Laboratory of Systems Biology, Department of Cybernetics, Tallinn University of Technology, Tallinn, Estonia.
Birkedal R; Laboratory of Systems Biology, Department of Cybernetics, Tallinn University of Technology, Tallinn, Estonia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 May 14; Vol. 10 (1), pp. 7956. Date of Electronic Publication: 2020 May 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Knockout Techniques*
Hindlimb*
Amidinotransferases/*genetics
Creatine/*deficiency
Guanidinoacetate N-Methyltransferase/*genetics
Muscles/*enzymology
Amidinotransferases/deficiency ; Animals ; Biomarkers/metabolism ; Female ; Guanidinoacetate N-Methyltransferase/deficiency ; Male ; Mice ; Sex Characteristics ; Species Specificity

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Skocz do pozycji: 55.

Tytuł:: Regulation of Oocyte Apoptosis: A View from Gene Knockout Mice.
Autorzy:: Kaur S; Department of Biological Sciences, Kent State University, Room 108, Kent, OH 44242, USA.
Kurokawa M; Department of Biological Sciences, Kent State University, Room 108, Kent, OH 44242, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 10; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 10.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Sexual Maturation*
Oocytes*/metabolism
Humans ; Female ; Animals ; Mice ; Gene Knockout Techniques ; Mice, Knockout ; Apoptosis/genetics

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Skocz do pozycji: 56.

Tytuł:: Efficient derivation of knock-out and knock-in rats using embryos obtained by in vitro fertilization.
Autorzy:: Honda A; Institute of Laboratory Animals, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan. .; RIKEN BioResource Research Center, Tsukuba, Ibaraki, 305-0074, Japan. .
Tachibana R; Institute of Laboratory Animals, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Hamada K; Institute of Laboratory Animals, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Morita K; Institute of Laboratory Animals, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Mizuno N; Division of Stem Cell Therapy, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan.
Morita K; Institute of Laboratory Animals, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Asano M; Institute of Laboratory Animals, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Aug 09; Vol. 9 (1), pp. 11571. Date of Electronic Publication: 2019 Aug 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Knock-In Techniques*/methods
Gene Knock-In Techniques*/veterinary
Gene Knockout Techniques*/methods
Gene Knockout Techniques*/veterinary
Rats/*embryology
Animals ; CRISPR-Cas Systems ; Electroporation/methods ; Electroporation/veterinary ; Female ; Fertilization in Vitro/methods ; Fertilization in Vitro/veterinary ; Gene Editing/methods ; Gene Editing/veterinary ; Male ; Rats/genetics ; Rats/physiology ; Rats, Inbred F344/embryology ; Rats, Inbred F344/genetics ; Rats, Inbred F344/physiology ; Rats, Long-Evans/embryology ; Rats, Long-Evans/genetics ; Rats, Long-Evans/physiology ; Rats, Sprague-Dawley/embryology ; Rats, Sprague-Dawley/genetics ; Rats, Sprague-Dawley/physiology ; Rats, Wistar/embryology ; Rats, Wistar/genetics ; Rats, Wistar/physiology ; Superovulation

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Tytuł:: Gut Microbiota Alterations in Trace Amine-Associated Receptor 9 (TAAR9) Knockout Rats.
Autorzy:: Zhukov IS; Institute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya nab. 7/9, 199034 Saint Petersburg, Russia.; Institute of Experimental Medicine, Acad. Pavlov str. 12, 197376 St. Petersburg, Russia.
Vaganova AN; Institute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya nab. 7/9, 199034 Saint Petersburg, Russia.
Murtazina RZ; Institute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya nab. 7/9, 199034 Saint Petersburg, Russia.
Alferova LS; Institute of Experimental Medicine, Acad. Pavlov str. 12, 197376 St. Petersburg, Russia.
Ermolenko EI; Institute of Experimental Medicine, Acad. Pavlov str. 12, 197376 St. Petersburg, Russia.
Gainetdinov RR; Institute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya nab. 7/9, 199034 Saint Petersburg, Russia.; St. Petersburg University Hospital, Saint Petersburg State University, Universitetskaya nab. 7/9, 199034 Saint Petersburg, Russia.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2022 Dec 06; Vol. 12 (12). Date of Electronic Publication: 2022 Dec 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Dopamine*/metabolism
Gastrointestinal Microbiome*
Receptors, G-Protein-Coupled*/genetics
Receptors, G-Protein-Coupled*/metabolism
Animals ; Rats ; Central Nervous System/metabolism ; Signal Transduction ; Gene Knockout Techniques ; Feces/microbiology

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Tytuł:: Preliminary study on the effect of catabolite repression gene knockout on p-nitrophenol degradation in Pseudomonas putida DLL-E4.
Autorzy:: Li S; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Tang Y; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Tang L; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Yan X; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Xiao J; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Xiang H; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Wu Q; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Yu R; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Jin Y; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Yu J; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Xu N; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Wu C; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Wang S; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Wang C; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.
Chen Q; College of Life and Environmental Science, Wenzhou University, Wenzhou, People's Republic of China.; National and Local Joint Engineering Research Center for Ecological Treatment Technology of Urban Water Pollution, Wenzhou University, Wenzhou, People's Republic of China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Dec 02; Vol. 17 (12), pp. e0278503. Date of Electronic Publication: 2022 Dec 02 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Catabolite Repression*/genetics
Pseudomonas putida*/genetics
Craniocerebral Trauma*
Humans ; Gene Knockout Techniques ; Glucose

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Tytuł:: Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes.
Autorzy:: Higgins K; The University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Moore BA; Department of Small Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville, FL, 32608, USA.
Berberovic Z; The Centre for Phenogenomics, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Adissu HA; Covance Inc, Chantilly, VA, 20151, USA.
Eskandarian M; The Centre for Phenogenomics, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Flenniken AM; The Centre for Phenogenomics, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Shao A; University of Reno, Nevada, School of Medicine, Reno, NV, 89557, USA.
Imai DM; Comparative Pathology Laboratory, U.C. Davis, Davis, 95616, USA.
Clary D; Mouse Biology Program, U.C. Davis, Davis, CA, 95618, USA.
Lanoue L; Mouse Biology Program, U.C. Davis, Davis, CA, 95618, USA.
Newbigging S; The Centre for Phenogenomics, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Nutter LMJ; The Centre for Phenogenomics, Toronto, ON, Canada.; The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Adams DJ; The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Bosch F; Centre of Animal Biotechnology and Gene Therapy (CBATEG), Universitat Autònoma de Barcelona, 08193, Barcelona, Spain.
Braun RE; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Brown SDM; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell Campus, Oxfordshire, OX11 0RD, UK.
Dickinson ME; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Dobbie M; Phenomics Australia, The Australian National University, 131 Garran Rd, Acton, Canberra, ACT, 2601, Australia.
Flicek P; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Gao X; SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, 210061, China.
Galande S; Indian Institutes of Science Education and Research, Dr. Homi Bhabha Rd, Ward No. 8, NCL Colony, Pashan, Pune, Maharashtra, 411008, India.
Grobler A; Faculty of Health Sciences, PCDDP North-West University, North-West University Potchefstroom Campus 11 Hoffman Street, Potchefstroom, 2531, South Africa.
Heaney JD; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Herault Y; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 67400, Illkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France.; Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, Université of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch-Graffenstaden, France.
de Angelis MH; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Chin HG; National Laboratory Animal Center, National Applied Research Laboratories (NARLabs), 3F., No. 106, Sec. 2, Heping E. Rd., Da'an Dist., Taipei City, 106214, Taiwan (R.O.C.).
Mammano F; Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Adriano Buzzati-Traverso Campus, Via Ramarini, 00015, Monterotondo Scalo, Italy.
Qin C; National Laboratory Animal Center, National Applied Research Laboratories (NARLabs), Beijing, China.; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Science, 5 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China.
Shiroishi T; RIKEN BioResource Center, Tsukuba, Ibaraki, 305-0074, Japan.
Sedlacek R; Czech Center for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, IMG BIOCEV Building SO.02 Prumyslova 595, 252 50, Vestec, Czech Republic.
Seong JK; Korea Mouse Phenotyping Consortium (KMPC) and BK21 Program for Veterinary Science, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 599 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea.
Xu Y; CAM-SU Genomic Resource Center, Soochow University, Organization Planning of No. 1 Shizi Street, Suzhou, 215123, China.
Lloyd KCK; Mouse Biology Program, U.C. Davis, Davis, CA, 95618, USA.; Department of Surgery, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.
McKerlie C; The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. .; Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children (SickKids), The Centre for Phenogenomics, Faculty of Medicine, University of Toronto, 25 Orde Street, Toronto, ON, M5T 3H7, USA. .
Moshiri A; Department of Ophthalmology and Vision Science, School of Medicine, U.C. Davis Eye Center, 4860 Y. Street, Suite 2400, Sacramento, CA, 95817, USA. .; Pokaż więcej
Corporate Authors:: IMPC Consortium
Źródło:: Scientific reports [Sci Rep] 2022 Dec 01; Vol. 12 (1), pp. 20791. Date of Electronic Publication: 2022 Dec 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Ciliopathies*/genetics
Mice ; Animals ; Mice, Knockout ; Gene Knockout Techniques ; Cilia/genetics ; Databases, Factual ; Nerve Tissue Proteins ; Cell Cycle Proteins

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Tytuł:: Adaptation of the yeast gene knockout collection is near-perfectly predicted by fitness and diminishing return epistasis.
Autorzy:: Persson K; Department of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.; Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Gothenburg, Sweden.
Stenberg S; Department of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.
Tamás MJ; Department of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.
Warringer J; Department of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.; Pokaż więcej
Źródło:: G3 (Bethesda, Md.) [G3 (Bethesda)] 2022 Nov 04; Vol. 12 (11).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Saccharomyces cerevisiae*/genetics
Saccharomyces cerevisiae*/metabolism
Arsenic*/metabolism
Epistasis, Genetic ; Genetic Fitness ; Gene Knockout Techniques ; Adaptation, Physiological/genetics ; Mutation ; Evolution, Molecular

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