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Tytuł :
The utility and limitations of B- and T-cell gene rearrangement studies in evaluating lymphoproliferative disorders.
Autorzy :
Mendoza H; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
Tormey CA; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
Rinder HM; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA; Hematology Section, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Howe JG; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
Siddon AJ; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT, USA. Electronic address: .
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Źródło :
Pathology [Pathology] 2021 Feb; Vol. 53 (2), pp. 157-165. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Rearrangement, B-Lymphocyte*
Gene Rearrangement, T-Lymphocyte*
Lymphoproliferative Disorders/*pathology
B-Lymphocyte Subsets ; B-Lymphocytes/pathology ; Gene Rearrangement ; Humans ; Lymphoproliferative Disorders/diagnosis ; Polymerase Chain Reaction/methods ; Receptors, Antigen, T-Cell/genetics ; Receptors, Cell Surface/genetics ; T-Lymphocyte Subsets ; T-Lymphocytes/pathology
Czasopismo naukowe
Tytuł :
TERT gene rearrangement in chordomas and comparison to other TERT-rearranged solid tumors.
Autorzy :
Yoon JY; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States; Department of Laboratory Medicine, St. Michael's Hospital/Unity Health Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address: .
Jiang W; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.
Orr CR; Center for Personalized Diagnostics, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Rushton C; Center for Personalized Diagnostics, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Gargano S; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.
Song SJ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Modi M; Department of Pathology, Pennsylvania Hospital, Philadelphia, Pennsylvania, United States.
Hozack B; Rothman Orthopedic Institute, Philadelphia, Pennsylvania, United States.
Abraham J; Rothman Orthopedic Institute, Philadelphia, Pennsylvania, United States; Division of Sarcoma and Bone Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States.
Mallick AB; Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.
Brooks JSJ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States; Department of Pathology, Pennsylvania Hospital, Philadelphia, Pennsylvania, United States.
Rosenbaum JN; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States; Center for Personalized Diagnostics, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Zhang PJ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States. Electronic address: .
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Źródło :
Cancer genetics [Cancer Genet] 2021 Nov; Vol. 258-259, pp. 74-79. Date of Electronic Publication: 2021 Sep 20.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Gene Rearrangement*
Chordoma/*pathology
Neoplasms/*pathology
Telomerase/*genetics
Chordoma/genetics ; Female ; Humans ; Middle Aged ; Neoplasms/genetics ; Prognosis
Czasopismo naukowe
Tytuł :
Expanding the Spectrum of EWSR1-NFATC2-rearranged Benign Tumors: A Common Genomic Abnormality in Vascular Malformation/Hemangioma and Simple Bone Cyst.
Autorzy :
Ong SLM; Departments of Pathology.
Lam SW; Departments of Pathology.
van den Akker BEWM; Departments of Pathology.
Kroon HM; Radiology.
Briaire-de Bruijn IH; Departments of Pathology.
Cleven AHG; Departments of Pathology.
Savci-Heijink DC; Department of Pathology, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Cleton-Jansen AM; Departments of Pathology.
Baumhoer D; Department of Medical Genetics and Pathology, Bone Tumor Reference Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Szuhai K; Cell and Chemical Biology, Leiden University Medical Center, Leiden.
Bovée JVMG; Departments of Pathology.
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Źródło :
The American journal of surgical pathology [Am J Surg Pathol] 2021 Dec 01; Vol. 45 (12), pp. 1669-1681.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Fusion*
Gene Rearrangement*
Biomarkers, Tumor/*genetics
Bone Cysts, Aneurysmal/*genetics
Hemangioma/*genetics
NFATC Transcription Factors/*genetics
RNA-Binding Protein EWS/*genetics
Adolescent ; Adult ; Aggrecans/analysis ; Biomarkers, Tumor/analysis ; Bone Cysts, Aneurysmal/chemistry ; Bone Cysts, Aneurysmal/pathology ; Child ; Female ; Genetic Predisposition to Disease ; Hemangioma/chemistry ; Hemangioma/pathology ; Homeobox Protein Nkx-2.2 ; Homeodomain Proteins/analysis ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Male ; Middle Aged ; Multiplex Polymerase Chain Reaction ; Nuclear Proteins ; Phenotype ; Transcription Factors/analysis ; Zebrafish Proteins/analysis
Czasopismo naukowe
Tytuł :
Clinicopathologic and Genomic Characterization of Inflammatory Myofibroblastic Tumors of the Head and Neck: Highlighting a Novel Fusion and Potential Diagnostic Pitfall.
Autorzy :
Kerr DA; Departments of Pathology and Laboratory Medicine.; Geisel School of Medicine at Dartmouth, Hanover, NH.
Thompson LDR; Department of Pathology, Southern California Permanente Medical Group, Woodland Hills, CA.
Tafe LJ; Departments of Pathology and Laboratory Medicine.; Geisel School of Medicine at Dartmouth, Hanover, NH.
Jo VY; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School.
Neyaz A; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Divakar P; Section of Otolaryngology, Dartmouth-Hitchcock Medical Center, Lebanon.
Paydarfar JA; Section of Otolaryngology, Dartmouth-Hitchcock Medical Center, Lebanon.; Geisel School of Medicine at Dartmouth, Hanover, NH.
Pastel DA; Radiology.; Geisel School of Medicine at Dartmouth, Hanover, NH.
Shirai K; Medical Oncology.; Geisel School of Medicine at Dartmouth, Hanover, NH.
John I; Department of Pathology, University of Pittsburgh.
Seethala RR; Department of Pathology, University of Pittsburgh.
Salgado CM; Department of Pathology, Children's Hospital of Pittsburgh, Pittsburgh, PA.
Deshpande V; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Bridge JA; Molecular Division, ProPath LLC, Dallas, TX.; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE.
Kashofer K; Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
Brčić I; Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
Linos K; Departments of Pathology and Laboratory Medicine.; Geisel School of Medicine at Dartmouth, Hanover, NH.
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Źródło :
The American journal of surgical pathology [Am J Surg Pathol] 2021 Dec 01; Vol. 45 (12), pp. 1707-1719.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Fusion*
Gene Rearrangement*
Molecular Diagnostic Techniques*
Biomarkers, Tumor/*genetics
Head and Neck Neoplasms/*genetics
Neoplasms, Muscle Tissue/*genetics
Adolescent ; Adult ; Aged ; Child ; Diagnosis, Differential ; Female ; Gene Expression Profiling ; Genetic Predisposition to Disease ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/therapy ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasms, Muscle Tissue/pathology ; Neoplasms, Muscle Tissue/therapy ; Phenotype ; Predictive Value of Tests ; RNA-Seq ; Treatment Outcome ; United States
Czasopismo naukowe
Tytuł :
Clonal IgH gene rearrangements identify Richter's transformation to diffuse large B cell lymphoma.
Autorzy :
Dalela D; Department of Medicine, Division of Hematology/Oncology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA, 01655, USA.
Bledsoe JR; Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA, 01655, USA.
Patel SA; Department of Medicine, Division of Hematology/Oncology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA, 01655, USA. .
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Źródło :
Annals of hematology [Ann Hematol] 2021 Dec; Vol. 100 (12), pp. 3075-3077. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Gene Rearrangement*
Genes, Immunoglobulin Heavy Chain*
Lymphoma, Large B-Cell, Diffuse/*genetics
Aged ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Disease Progression ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Lymphoma, Large B-Cell, Diffuse/pathology
Raport
Tytuł :
Chromothripsis followed by circular recombination drives oncogene amplification in human cancer.
Autorzy :
Rosswog C; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany.
Bartenhagen C; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Welte A; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Kahlert Y; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Hemstedt N; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Lorenz W; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Cartolano M; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Ackermann S; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Perner S; Institute of Pathology, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.; Pathology Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Vogel W; Institute of Pathology, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.; Pathology Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Altmüller J; Cologne Center for Genomics (CCG), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Facility Genomics, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Nürnberg P; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Center for Genomics (CCG), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Hertwig F; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Göhring G; Department of Human Genetics, Hannover Medical School (MHH), Hannover, Germany.
Lilienweiss E; Department of Internal Medicine, University of Cologne, Cologne, Germany.
Stütz AM; European Molecular Biology Laboratory Genome Biology Unit, Heidelberg, Germany.
Korbel JO; European Molecular Biology Laboratory Genome Biology Unit, Heidelberg, Germany.
Thomas RK; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Department of Pathology, University of Cologne, Cologne, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Peifer M; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. .; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany. .
Fischer M; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. .; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. .
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Źródło :
Nature genetics [Nat Genet] 2021 Dec; Vol. 53 (12), pp. 1673-1685. Date of Electronic Publication: 2021 Nov 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromothripsis*
Gene Amplification*
Gene Rearrangement*
Oncogenes*
Neoplasms/*genetics
Cell Line, Tumor ; Cohort Studies ; DNA, Circular ; DNA, Neoplasm ; Humans ; Models, Genetic ; Mutation ; Neuroblastoma/genetics ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Deepening the Knowledge of ROS1 Rearrangements in Non-Small Cell Lung Cancer: Diagnosis, Treatment, Resistance and Concomitant Alterations.
Autorzy :
Guaitoli G; Ph.D. Program Clinical and Experimental Medicine (CEM), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.; Oncology and Hematology, Modena University Hospital, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Bertolini F; Oncology and Hematology, Modena University Hospital, 41125 Modena, Italy.
Bettelli S; Molecular Pathology, Modena University Hospital, 41125 Modena, Italy.
Manfredini S; Molecular Pathology, Modena University Hospital, 41125 Modena, Italy.
Maur M; Oncology and Hematology, Modena University Hospital, 41125 Modena, Italy.
Trudu L; Oncology and Hematology, Modena University Hospital, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Aramini B; Thoracic Surgery Unit, Department of Diagnostic and Specialty Medicine-DIMES of the Alma Mater Studiorum, University of Bologna, G.B. Morgagni-L. Pierantoni Hospital, 47121 Forlì, Italy.
Masciale V; Laboratory of Cellular Therapy, Program of Cell Therapy and Immuno-Oncology, Division of Oncology, University-Hospital of Modena and Reggio Emilia, Department of Medical and Surgical Sciences for Children & Adults, 41125 Modena, Italy.
Grisendi G; Laboratory of Cellular Therapy, Program of Cell Therapy and Immuno-Oncology, Division of Oncology, University-Hospital of Modena and Reggio Emilia, Department of Medical and Surgical Sciences for Children & Adults, 41125 Modena, Italy.
Dominici M; Oncology and Hematology, Modena University Hospital, University of Modena and Reggio Emilia, 41125 Modena, Italy.; Laboratory of Cellular Therapy, Program of Cell Therapy and Immuno-Oncology, Division of Oncology, University-Hospital of Modena and Reggio Emilia, Department of Medical and Surgical Sciences for Children & Adults, 41125 Modena, Italy.
Barbieri F; Oncology and Hematology, Modena University Hospital, 41125 Modena, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 28; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Rearrangement*
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Protein-Tyrosine Kinases/*genetics
Proto-Oncogene Proteins/*genetics
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Crizotinib/pharmacology ; Crizotinib/therapeutic use ; Drug Resistance, Neoplasm ; High-Throughput Nucleotide Sequencing ; Humans ; In Situ Hybridization, Fluorescence ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Comparative efficacy and safety of first-line treatments for advanced non-small cell lung cancer with ALK-rearranged: a meta-analysis of clinical trials.
Autorzy :
Ma HC; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.; The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Liu YH; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.
Ding KL; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.; The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Liu YF; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.; The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Zhao WJ; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.; The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Zhu YJ; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.; The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory, of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, 510120, China.
Chang XS; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.; The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Chen YD; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.
Xiao ZZ; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.
Yu YY; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.
Zhou R; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.; The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Zhang HB; Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China. .; The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China. .; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China. .; Guangdong Provincial Key Laboratory, of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, 510120, China. .; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Nov 26; Vol. 21 (1), pp. 1278. Date of Electronic Publication: 2021 Nov 26.
Typ publikacji :
Comparative Study; Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Gene Rearrangement*
Anaplastic Lymphoma Kinase/*genetics
Antineoplastic Agents/*therapeutic use
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Aminopyridines/adverse effects ; Aminopyridines/therapeutic use ; Antineoplastic Agents/adverse effects ; Carbazoles/adverse effects ; Carbazoles/therapeutic use ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Humans ; Lactams/adverse effects ; Lactams/therapeutic use ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Network Meta-Analysis ; Organophosphorus Compounds/adverse effects ; Organophosphorus Compounds/therapeutic use ; Piperazines/adverse effects ; Piperazines/therapeutic use ; Piperidines/adverse effects ; Piperidines/therapeutic use ; Progression-Free Survival ; Protein Kinase Inhibitors/adverse effects ; Pyrazoles/adverse effects ; Pyrazoles/therapeutic use ; Pyridazines/adverse effects ; Pyridazines/therapeutic use ; Pyrimidines/adverse effects ; Pyrimidines/therapeutic use ; Randomized Controlled Trials as Topic ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Combination efficacy of ruxolitinib with standard-of-care drugs in CRLF2-rearranged Ph-like acute lymphoblastic leukemia.
Autorzy :
Bӧhm JW; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.
Sia KCS; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.
Jones C; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.
Evans K; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.
Mariana A; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.
Pang I; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, Australia.
Failes T; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.
Zhong L; Bioanalytical Mass Spectrometry Facility, UNSW Sydney, Sydney, NSW, Australia.
Mayoh C; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.
Landman R; Incyte Corporation, Wilmington, DE, USA.
Collins R; Incyte Corporation, Wilmington, DE, USA.
Erickson SW; RTI International, Research Triangle Park, NC, USA.
Arndt G; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.
Raftery MJ; Bioanalytical Mass Spectrometry Facility, UNSW Sydney, Sydney, NSW, Australia.
Wilkins MR; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, Australia.
Norris MD; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.
Haber M; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.
Marshall GM; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.
Lock RB; Children's Cancer Institute, School of Women's and Children's Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia. .
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Źródło :
Leukemia [Leukemia] 2021 Nov; Vol. 35 (11), pp. 3101-3112. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Rearrangement*
Philadelphia Chromosome*
Nitriles/*pharmacology
Pharmaceutical Preparations/*administration & dosage
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Pyrazoles/*pharmacology
Pyrimidines/*pharmacology
Receptors, Cytokine/*genetics
Animals ; Apoptosis ; Cell Proliferation ; Drug Therapy, Combination ; Female ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia.
Autorzy :
Kiehlmeier S; Molecular Leukemogenesis, German Cancer Research Center, Heidelberg, Germany.
Rafiee MR; Bioinformatics and Computational Biology Laboratory, The Francis Crick Institute, London, United Kingdom.; Proteomics of Stem Cells and Cancer, German Cancer Research Center, Heidelberg, Germany.
Bakr A; Cancer Epigenomics, German Cancer Research Center, Heidelberg, Germany.
Mika J; Molecular Leukemogenesis, German Cancer Research Center, Heidelberg, Germany.
Kruse S; Molecular Leukemogenesis, German Cancer Research Center, Heidelberg, Germany.
Müller J; Molecular Leukemogenesis, German Cancer Research Center, Heidelberg, Germany.
Schweiggert S; Molecular Leukemogenesis, German Cancer Research Center, Heidelberg, Germany.
Herrmann C; Health Data Science Unit, Medical Faculty Heidelberg and BioQuant, Heidelberg, Germany.
Sigismondo G; Proteomics of Stem Cells and Cancer, German Cancer Research Center, Heidelberg, Germany.
Schmezer P; Cancer Epigenomics, German Cancer Research Center, Heidelberg, Germany.
Krijgsveld J; Proteomics of Stem Cells and Cancer, German Cancer Research Center, Heidelberg, Germany.; Heidelberg University, Medical Faculty, Heidelberg, Germany.
Gröschel S; Molecular Leukemogenesis, German Cancer Research Center, Heidelberg, Germany. .; Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany. .; Oncology Center Worms, Worms, Germany. .
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Źródło :
Leukemia [Leukemia] 2021 Nov; Vol. 35 (11), pp. 3127-3138. Date of Electronic Publication: 2021 Apr 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enhancer Elements, Genetic*
Gene Expression Regulation, Leukemic*
Gene Rearrangement*
Core Binding Factor Alpha 2 Subunit/*metabolism
GATA2 Transcription Factor/*metabolism
Leukemia, Myeloid, Acute/*pathology
MDS1 and EVI1 Complex Locus Protein/*metabolism
CCAAT-Enhancer-Binding Proteins/genetics ; CCAAT-Enhancer-Binding Proteins/metabolism ; Carcinogenesis ; Chromosome Aberrations ; Core Binding Factor Alpha 2 Subunit/genetics ; GATA2 Transcription Factor/genetics ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; MDS1 and EVI1 Complex Locus Protein/genetics ; Proto-Oncogene Proteins c-myb/genetics ; Proto-Oncogene Proteins c-myb/metabolism ; Translocation, Genetic ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Identification of KMT2A-ARHGEF12 fusion in a child with a high-grade B-cell lymphoma.
Autorzy :
Schafernak KT; Department of Pathology and Laboratory Medicine, Phoenix Children's Hospital, Phoenix, AZ, United States.
Williams JA; Center for Cancer & Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, United States.
Clyde BI; ARUP Laboratories, Salt Lake City, UT, United States.
Marcus C; Foundation Medicine, Inc., Cambridge, MA, United States.
Decker B; Foundation Medicine, Inc., Cambridge, MA, United States.
Toydemir RM; ARUP Laboratories, Salt Lake City, UT, United States; Department of Pathology, University of Utah, Salt Lake City, UT, United States. Electronic address: .
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Źródło :
Cancer genetics [Cancer Genet] 2021 Nov; Vol. 258-259, pp. 23-26. Date of Electronic Publication: 2021 Jun 27.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Gene Rearrangement*
Histone-Lysine N-Methyltransferase/*genetics
Lymphoma, B-Cell/*pathology
Myeloid-Lymphoid Leukemia Protein/*genetics
Oncogene Proteins, Fusion/*genetics
Rho Guanine Nucleotide Exchange Factors/*genetics
Child ; Humans ; Lymphoma, B-Cell/genetics ; Male ; Prognosis
Czasopismo naukowe
Tytuł :
A rare case of atypical chronic myeloid leukemia associated with t(8;22)(p11.2;q11.2)/ BCR-FGFR1 rearrangement: A case report and literature review.
Autorzy :
Washburn E; Department of Pathology, Penn State Hershey Health Medical Center, Hershey Pennsylvania, PA, United States. Electronic address: .
Bayerl MG; Department of Pathology, Penn State Hershey Health Medical Center, Hershey Pennsylvania, PA, United States.
Ketterling RP; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.
Malysz J; Department of Pathology, Penn State Hershey Health Medical Center, Hershey Pennsylvania, PA, United States.
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Źródło :
Cancer genetics [Cancer Genet] 2021 Nov; Vol. 258-259, pp. 69-73. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Gene Rearrangement*
Translocation, Genetic*
Chromosomes, Human, Pair 22/*genetics
Chromosomes, Human, Pair 8/*genetics
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/*pathology
Proto-Oncogene Proteins c-bcr/*genetics
Receptor, Fibroblast Growth Factor, Type 1/*genetics
Humans ; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/genetics ; Male ; Middle Aged ; Prognosis
Czasopismo naukowe
Tytuł :
A pediatric BAL case with double Ph chromosomes and trisomy 5.
Autorzy :
Gunden G; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey. Electronic address: .
Isik S; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey. Electronic address: .
Ozdemir C; Department of Pediatric Hematology, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey.
Cİlİngİr O; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey.
Bor O; Department of Pediatric Hematology, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey.
Gokalp EE; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey.
Kocagil S; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey.
Artan S; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey.
Aras BD; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey.
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Źródło :
Cancer genetics [Cancer Genet] 2021 Nov; Vol. 258-259, pp. 7-9. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Chromosome Aberrations*
Gene Rearrangement*
Philadelphia Chromosome*
Cri-du-Chat Syndrome/*genetics
Leukemia, Biphenotypic, Acute/*genetics
Leukemia, Biphenotypic, Acute/*pathology
Trisomy/*genetics
Child, Preschool ; Chromosomes, Human, Pair 5/genetics ; Humans ; Male ; Prognosis
SCR Disease Name :
Chromosome 5, trisomy 5q
Czasopismo naukowe
Tytuł :
Identification of variant APL translocations PRKAR1A-RARα and ZBTB16-RARα (PLZF-RARα) through the MI-ONCOSEQ platform.
Autorzy :
King D; Division of Hematology and Medical Oncology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.
Foucar CE; Division of Hematology and Medical Oncology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.
Ma V; Division of Hematology and Medical Oncology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.
Benitez L; Department of Pharmacy, Michigan Medicine, Ann Arbor, Michigan, USA.
Perissinotti AJ; Department of Pharmacy, Michigan Medicine, Ann Arbor, Michigan, USA.
Marini BL; Department of Pharmacy, Michigan Medicine, Ann Arbor, Michigan, USA.
Robinson D; Michigan Center for Translational Pathology, Michigan Medicine, Ann Arbor, Michigan, USA.
Bhave RR; Division of Hematology and Medical Oncology, Wake Forrest University, Winston-Salem, North Carolina, USA.
Bixby D; Division of Hematology and Medical Oncology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA. Electronic address: .
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Źródło :
Cancer genetics [Cancer Genet] 2021 Nov; Vol. 258-259, pp. 57-60. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Gene Rearrangement*
Translocation, Genetic*
Cyclic AMP-Dependent Protein Kinase RIalpha Subunit/*genetics
Leukemia, Promyelocytic, Acute/*genetics
Leukemia, Promyelocytic, Acute/*pathology
Oncogene Proteins, Fusion/*genetics
Retinoic Acid Receptor alpha/*genetics
Adult ; Aged ; Female ; Humans ; Prognosis ; Young Adult
Czasopismo naukowe
Tytuł :
Clinical characteristics and outcomes of B-ALL with ZNF384 rearrangements: a retrospective analysis by the Ponte di Legno Childhood ALL Working Group.
Autorzy :
Hirabayashi S; Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Butler ER; Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Ohki K; Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
Kiyokawa N; Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
Bergmann AK; Hannover Medical School, Institute of Human Genetics, Hannover, Germany.
Möricke A; Department of Pediatrics, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Boer JM; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.
Cavé H; Department of Genetics, Robert Debré Hospital and University of Paris, Paris, France.
Cazzaniga G; Centro Ricerca Tettamanti, Pediatric Clinic University of Milano-Bicocca, Monza, Italy.
Yeoh AEJ; Khoo Teck Puat - National University Children's Medical Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Sanada M; Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Imamura T; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Inaba H; St Jude Children's Research Hospital and Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.
Mullighan C; St Jude Children's Research Hospital and Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.
Loh ML; Department of Pediatrics, Benioff Children's Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Norén-Nyström U; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Pastorczak A; Department of Pediatric, Oncology, Hematology and Diabetology, Medical University of Łódź, Poland, CA, Poland.
Shih LY; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taoyuan, Taiwan.
Zaliova M; CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, 2nd Faculty of Medicine, Prague, Czech Republic.
Pui CH; St Jude Children's Research Hospital and Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.
Haas OA; Children's Cancer Research Institute, Vienna, Austria.
Harrison CJ; Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Moorman AV; Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Manabe A; Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan. .
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Źródło :
Leukemia [Leukemia] 2021 Nov; Vol. 35 (11), pp. 3272-3277. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Rearrangement*
Biomarkers, Tumor/*genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*pathology
Trans-Activators/*genetics
Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Prognosis ; Retrospective Studies ; Survival Rate ; Young Adult
Czasopismo naukowe
Tytuł :
Pan-TRK Immunohistochemistry Is Highly Correlated With NTRK3 Gene Rearrangements in Salivary Gland Tumors.
Autorzy :
Csanyi-Bastien M; Department of Pathology, Centre Henri Becquerel.
Lanic MD; INSERM 1245, Rouen Normandy Uniiversity.
Beaussire L; Department of Pathology, Centre Henri Becquerel.
Ferric S; Department of Pathology, Centre Henri Becquerel.
François A; Department of Pathology, Rouen University Hospital, Rouen.
Meseure D; Platform of Experimental Pathology, Department of Diagnostic and Theranostic Medicine, Curie Institute.
Jardin F; INSERM 1245, Rouen Normandy Uniiversity.
Wassef M; Department of Pathology, Lariboisière Hospital, Paris, France.
Ruminy P; INSERM 1245, Rouen Normandy Uniiversity.
Laé M; Department of Pathology, Centre Henri Becquerel.; INSERM 1245, Rouen Normandy Uniiversity.
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Źródło :
The American journal of surgical pathology [Am J Surg Pathol] 2021 Nov 01; Vol. 45 (11), pp. 1487-1498.
Typ publikacji :
Comparative Study; Journal Article; Multicenter Study
MeSH Terms :
Gene Fusion*
Gene Rearrangement*
Immunohistochemistry*
Biomarkers, Tumor/*genetics
Oncogene Proteins, Fusion/*genetics
Receptor, trkC/*genetics
Salivary Gland Neoplasms/*genetics
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; France ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Middle Aged ; Multiplex Polymerase Chain Reaction ; Phenotype ; Predictive Value of Tests ; Reproducibility of Results ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; Salivary Gland Neoplasms/pathology ; Young Adult
Czasopismo naukowe
Tytuł :
Massive gene rearrangement in mitogenomes of phytoseiid mites.
Autorzy :
Zhang B; Laboratory of Predatory Mites, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China.
Havird JC; Department of Integrative Biology, University of Texas, Austin, TX 78712, USA.
Wang E; Laboratory of Predatory Mites, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China.
Lv J; Laboratory of Predatory Mites, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China.
Xu X; Laboratory of Predatory Mites, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Sep 01; Vol. 186, pp. 33-39. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Evolution, Molecular*
Gene Order*
Gene Rearrangement*
Genome, Mitochondrial*
Mites/*genetics
Mitochondria/*genetics
Animals ; Diet ; Feeding Behavior ; Phylogeny
Czasopismo naukowe
Tytuł :
Novel tRNA gene rearrangements in the mitochondrial genomes of praying mantises (Mantodea: Mantidae): Translocation, duplication and pseudogenization.
Autorzy :
Xu XD; College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang Province, China.
Guan JY; College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang Province, China.
Zhang ZY; College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang Province, China.
Cao YR; College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang Province, China.
Storey KB; Department of Biology, Carleton University, Ottawa, Canada. Electronic address: .
Yu DN; College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang Province, China; Key Lab of Wildlife Biotechnology, Conservation and Utilization of Zhejiang Province, Zhejiang Normal University, Jinhua, Zhejiang Province, China. Electronic address: .
Zhang JY; College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang Province, China; Key Lab of Wildlife Biotechnology, Conservation and Utilization of Zhejiang Province, Zhejiang Normal University, Jinhua, Zhejiang Province, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 403-411. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Rearrangement*
Mantodea/*genetics
Mitochondria/*genetics
RNA, Transfer/*genetics
Animals ; Evolution, Molecular ; Gene Duplication ; Gene Order ; Genome, Mitochondrial ; Nucleic Acid Conformation ; Phylogeny ; Pseudogenes ; RNA, Plant/genetics ; RNA, Transfer/chemistry ; Sequence Analysis, DNA ; Translocation, Genetic
Czasopismo naukowe
Tytuł :
Gemtuzumab Ozogamicin Improves Event-Free Survival and Reduces Relapse in Pediatric KMT2A -Rearranged AML: Results From the Phase III Children's Oncology Group Trial AAML0531.
Autorzy :
Pollard JA; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Department of Pediatrics, Harvard Medical School, Boston, MA.
Guest E; Children's Mercy, Kansas City, MO.
Alonzo TA; University of Southern California Keck School of Medicine, Los Angeles, CA.; Children's Oncology Group, Monrovia, CA.
Gerbing RB; Children's Oncology Group, Monrovia, CA.
Loken MR; Hematologics Inc, Seattle, WA.
Brodersen LE; Hematologics Inc, Seattle, WA.
Kolb EA; Nemours Children Health System, Wilmington, DE.
Aplenc R; Children's Hospital of Philadelphia, Philadelphia, PA.
Meshinchi S; Fred Hutchinson Cancer Research Center, Seattle, WA.; University of Washington School of Medicine, Seattle, WA.
Raimondi SC; St Jude Children's Research Hospital, Memphis, TN.
Hirsch B; University of Minnesota Cancer Center, Minneapolis, MN.
Gamis AS; Children's Mercy, Kansas City, MO.
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Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2021 Oct 01; Vol. 39 (28), pp. 3149-3160. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Rearrangement*
Antineoplastic Agents, Immunological/*therapeutic use
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Biomarkers, Tumor/*genetics
Gemtuzumab/*therapeutic use
Histone-Lysine N-Methyltransferase/*genetics
Leukemia, Myeloid, Acute/*drug therapy
Myeloid-Lymphoid Leukemia Protein/*genetics
Adolescent ; Anthracyclines/therapeutic use ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Child ; Child, Preschool ; Cytarabine/therapeutic use ; Female ; Gemtuzumab/adverse effects ; Hematopoietic Stem Cell Transplantation ; Humans ; Infant ; Infant, Newborn ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/pathology ; Male ; Progression-Free Survival ; Recurrence ; Risk Assessment ; Risk Factors ; Time Factors ; United States
Czasopismo naukowe
Tytuł :
Mechanism of chromosome rearrangement arising from single-strand breaks.
Autorzy :
Kot P; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523, Japan.
Yasuhara T; Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.
Shibata A; Gunma University Initiative for Advanced Research, Maebashi, Gunma, 371-8511, Japan.
Hirakawa M; Radioisotope Research Center, Life Science Support Center, Nagasaki University, Nagasaki, 852-8523, Japan.
Abe Y; Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan.
Yamauchi M; Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan. Electronic address: .
Matsuda N; Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Oct 01; Vol. 572, pp. 191-196. Date of Electronic Publication: 2021 Aug 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosomes/*genetics
Gene Rearrangement/*genetics
Homologous Recombination/*genetics
Cells, Cultured ; Chromosomes/drug effects ; Chromosomes/metabolism ; DNA Breaks, Double-Stranded/drug effects ; DNA Repair ; Gene Rearrangement/drug effects ; Humans ; Hydrogen Peroxide/pharmacology
Czasopismo naukowe

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