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Wyszukujesz frazę ""Gene knockdown"" wg kryterium: Temat


Tytuł:
Optimal combination of cationic lipid and phospholipid in cationic liposomes for gene knockdown in breast cancer cells and mouse lung using siRNA lipoplexes.
Autorzy:
Hattori Y; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Tang M; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Torii S; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Tomita K; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Sagawa A; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Inoue N; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Yamagishi R; Department of Molecular Pharmaceutics, Hoshi University, Tokyo 142-8501, Japan.
Ozaki KI; Department of Molecular Pathology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto 610-0395, Japan.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2022 Aug; Vol. 26 (2). Date of Electronic Publication: 2022 Jun 10.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Knockdown Techniques*
Liposomes*
Animals ; Cations ; Female ; Humans ; Luciferases ; Lung ; MCF-7 Cells ; Mice ; Phosphatidylcholines ; Phosphatidylethanolamines ; Phospholipids ; RNA, Small Interfering/genetics ; Transfection
Czasopismo naukowe
Tytuł:
Knockdown of long non-coding RNA plasmacytoma variant translocation 1 relieves ox-LDL-induced endothelial cell injury through regulating microRNA-30c-5p in atherosclerosis.
Autorzy:
Li G; Department of Cardiology, Hubei No. 3 People's Hospital of Jianghan University, Wuhan, China.
Zong W; Department of Cardiology, Hubei No. 3 People's Hospital of Jianghan University, Wuhan, China.
Liu L; Department of Cardiology, Hubei No. 3 People's Hospital of Jianghan University, Wuhan, China.
Wu J; Department of Medical Laboratory, Eleven Wuhan Hospital, Wuhan, Hubei Province, China.
Pang J; Department of Cardiology, Hubei No. 3 People's Hospital of Jianghan University, Wuhan, China.
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Źródło:
Bioengineered [Bioengineered] 2022 Feb; Vol. 13 (2), pp. 2791-2802.
Typ publikacji:
Journal Article; Video-Audio Media
MeSH Terms:
Atherosclerosis*/genetics
Atherosclerosis*/metabolism
Atherosclerosis*/pathology
Gene Expression Regulation*
Gene Knockdown Techniques*
Human Umbilical Vein Endothelial Cells/*metabolism
Lipoproteins, LDL/*metabolism
Adult ; Aged ; Female ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Lipoproteins, LDL/genetics ; Male ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; Middle Aged ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
Czasopismo naukowe
Tytuł:
Knockdown of ADORA2A antisense RNA 1 inhibits cell proliferation and enhances imatinib sensitivity in chronic myeloid leukemia.
Autorzy:
Liu Y; Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Li H; Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Zhao Y; Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Li D; Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Zhang Q; Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Fu J; Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Fan S; Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
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Źródło:
Bioengineered [Bioengineered] 2022 Feb; Vol. 13 (2), pp. 2296-2307.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms:
Cell Proliferation*/drug effects
Cell Proliferation*/genetics
Drug Resistance, Neoplasm*/drug effects
Drug Resistance, Neoplasm*/genetics
Gene Knockdown Techniques*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/metabolism
RNA, Antisense*/genetics
RNA, Antisense*/metabolism
RNA, Neoplasm*/genetics
RNA, Neoplasm*/metabolism
Imatinib Mesylate/*pharmacology
Adult ; Female ; HEK293 Cells ; Humans ; K562 Cells ; Male ; Middle Aged
Czasopismo naukowe
Tytuł:
CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis.
Autorzy:
Fu L; Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, China.; Department of Endocrinology, Haikou Hospital, Affiliated to Xiangya Medical College, Central South University, Haikou, China.
Zhang J; Department of Endocrinology, Haikou Hospital, Affiliated to Xiangya Medical College, Central South University, Haikou, China.
Lin Z; Department of Endocrinology, Haikou Hospital, Affiliated to Xiangya Medical College, Central South University, Haikou, China.
Li Y; Department of Clinical Medicine, Hainan Medical College, Haikou, China.
Qin G; Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, China.
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Źródło:
Bioengineered [Bioengineered] 2022 Feb; Vol. 13 (2), pp. 2398-2411.
Typ publikacji:
Journal Article; Video-Audio Media
MeSH Terms:
Gene Knockdown Techniques*
MicroRNAs*/genetics
MicroRNAs*/metabolism
Pore Forming Cytotoxic Proteins*/genetics
Pore Forming Cytotoxic Proteins*/metabolism
RNA, Circular*/genetics
RNA, Circular*/metabolism
Diabetic Cardiomyopathies/*metabolism
Animals ; Cell Line ; Diabetic Cardiomyopathies/genetics ; Diabetic Cardiomyopathies/prevention & control ; Male ; Mice ; Rats
Czasopismo naukowe
Tytuł:
Knockdown of long non-coding RNA SNHG8 suppresses the progression of esophageal cancer by regulating miR-1270/BACH1 axis.
Autorzy:
Wu Y; Department of Medical Insurance and Price, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Liang Y; Hematology Department, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Li M; Gastroenterology Department, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Zhang H; Oncology Department, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
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Źródło:
Bioengineered [Bioengineered] 2022 Feb; Vol. 13 (2), pp. 3384-3394.
Typ publikacji:
Journal Article; Video-Audio Media
MeSH Terms:
Basic-Leucine Zipper Transcription Factors*/genetics
Basic-Leucine Zipper Transcription Factors*/metabolism
Esophageal Neoplasms*/genetics
Esophageal Neoplasms*/metabolism
Gene Knockdown Techniques*
MicroRNAs*/genetics
MicroRNAs*/metabolism
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
RNA, Neoplasm*/genetics
RNA, Neoplasm*/metabolism
Signal Transduction*
Aged ; Cell Line, Tumor ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł:
Knockdown of circular RNA tousled-like kinase 1 relieves ischemic stroke in middle cerebral artery occlusion mice and oxygen-glucose deprivation and reoxygenation-induced N2a cell damage.
Autorzy:
Wu R; Department of Neurosurgery, Inner Mongolia People's Hospital, Hohhot, China.
Yun Q; Department of Neurosurgery, Inner Mongolia People's Hospital, Hohhot, China.
Zhang J; Department of Neurosurgery, Inner Mongolia People's Hospital, Hohhot, China.
Wang Z; Department of Neurosurgery, Inner Mongolia People's Hospital, Hohhot, China.
Zhang X; Department of Neurosurgery, Inner Mongolia People's Hospital, Hohhot, China.
Bao J; Department of Neurosurgery, Inner Mongolia People's Hospital, Hohhot, China.
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Źródło:
Bioengineered [Bioengineered] 2022 Feb; Vol. 13 (2), pp. 3434-3449.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms:
Gene Expression Regulation*
Gene Knockdown Techniques*
Infarction, Middle Cerebral Artery*/genetics
Infarction, Middle Cerebral Artery*/metabolism
Ischemic Stroke*/genetics
Ischemic Stroke*/metabolism
RNA, Circular*/genetics
RNA, Circular*/metabolism
Animals ; Cell Line, Tumor ; Male ; Mice
Czasopismo naukowe
Tytuł:
C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy.
Autorzy:
Cang X; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, The First People's Hospital of Nantong, Nantong, Jiangsu, China.
Wang Y; Department of Hepatobiliary Surgery, Jintan Affiliated Hospital of Jiangsu University, Changzhou, China.
Zeng J; Department of Pathogen Biology, Medical College, Nantong University, Nantong, Jiangsu, China.
Gao J; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yu Q; Department of Radiotherapy, Jintan Affiliated Hospital of Jiangsu University, Changzhou, China.
Lu C; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, The First People's Hospital of Nantong, Nantong, Jiangsu, China.
Xu F; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, The First People's Hospital of Nantong, Nantong, Jiangsu, China.
Lin J; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhu J; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: .
Wang X; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, The First People's Hospital of Nantong, Nantong, Jiangsu, China. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Jan 15; Vol. 588, pp. 15-22. Date of Electronic Publication: 2021 Dec 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Gene Knockdown Techniques*
Insulin Resistance*
C9orf72 Protein/*metabolism
Liver/*metabolism
Liver/*pathology
Animals ; Diabetes Mellitus, Type 2/pathology ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Male ; Mice, Inbred C57BL ; Mice, Obese ; Protein Binding ; Wiskott-Aldrich Syndrome Protein, Neuronal/metabolism ; cdc42 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł:
Knockdown of small nucleolar RNA host gene 10 (SNHG10) alleviates the injury of human neuroblastoma cells via the miR-1277-5p/insulin substrate receptor 2 axis.
Autorzy:
Sun Z; Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.
Song L; Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.
Li J; Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.
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Źródło:
Bioengineered [Bioengineered] 2022 Jan; Vol. 13 (1), pp. 709-720.
Typ publikacji:
Journal Article; Video-Audio Media
MeSH Terms:
Gene Knockdown Techniques*
Signal Transduction*
Insulin Receptor Substrate Proteins/*metabolism
MicroRNAs/*metabolism
Neoplasm Proteins/*metabolism
Neuroblastoma/*metabolism
RNA, Neoplasm/*metabolism
RNA, Small Nuclear/*metabolism
Cell Line, Tumor ; Humans ; Insulin Receptor Substrate Proteins/genetics ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; Neuroblastoma/genetics ; RNA, Neoplasm/genetics ; RNA, Small Nuclear/genetics
Czasopismo naukowe
Tytuł:
Protein tyrosine phosphatase receptor type O (PTPRO) knockdown enhances the proliferative, invasive and angiogenic activities of trophoblast cells by suppressing ER resident protein 44 (ERp44) expression in preeclampsia.
Autorzy:
Yang Y; Department of Obstetrics and Gynecology, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, Zhejiang, P.R. China.
Qiu X; Department of Obstetrics and Gynecology, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, Zhejiang, P.R. China.
Wang F; Department of Obstetrics and Gynecology, The Affiliated Shanghai East Hospital, Tongji University, Shanghai, P.R. China.
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Źródło:
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (2), pp. 9561-9574.
Typ publikacji:
Journal Article; Video-Audio Media
MeSH Terms:
Gene Expression Regulation*
Gene Knockdown Techniques*
Membrane Proteins*/genetics
Membrane Proteins*/metabolism
Molecular Chaperones*/genetics
Molecular Chaperones*/metabolism
Neovascularization, Pathologic*/genetics
Neovascularization, Pathologic*/metabolism
Pre-Eclampsia*/genetics
Pre-Eclampsia*/metabolism
Cell Proliferation/*genetics
Receptor-Like Protein Tyrosine Phosphatases, Class 3/*deficiency
Trophoblasts/*metabolism
Cell Line ; Female ; Human Umbilical Vein Endothelial Cells ; Humans ; Pregnancy ; Receptor-Like Protein Tyrosine Phosphatases, Class 3/metabolism
Czasopismo naukowe
Tytuł:
Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer.
Autorzy:
Cai C; Department of Gynaecology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China.
Zhang Y; Department of Gynaecology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China.
Peng X; Department of Gynaecology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China.
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Źródło:
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (2), pp. 9390-9400.
Typ publikacji:
Journal Article; Video-Audio Media
MeSH Terms:
Epithelial Sodium Channels*/genetics
Epithelial Sodium Channels*/metabolism
Gene Knockdown Techniques*
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/metabolism
Serine Endopeptidases*/genetics
Serine Endopeptidases*/metabolism
Sterol Regulatory Element Binding Protein 2*/genetics
Sterol Regulatory Element Binding Protein 2*/metabolism
Cell Movement/*genetics
Cell Proliferation/*genetics
Epithelial-Mesenchymal Transition/*genetics
Cell Line, Tumor ; Female ; Humans
Czasopismo naukowe
Tytuł:
Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells.
Autorzy:
Xu Q; Department of Gynaecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Liu Z; Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Zhu ZQ; Department of Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Fan Y; Department of Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Chen R; Department of Gynaecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Xie XH; Department of Gynaecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Cheng M; Department of Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
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Źródło:
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (2), pp. 12179-12190.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Knockdown Techniques*
GRB7 Adaptor Protein/*metabolism
Neovascularization, Pathologic/*metabolism
Ovarian Neoplasms/*blood supply
Ovarian Neoplasms/*metabolism
Vascular Endothelial Growth Factor A/*metabolism
Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Female ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Ovarian Neoplasms/pathology ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism
Czasopismo naukowe
Tytuł:
Knockdown of carbohydrate sulfotransferase 12 decreases the proliferation and mobility of glioblastoma cells via the WNT/β-catenin pathway.
Autorzy:
Wang J; Department of Neurology, Changle People's Hospital, Weifang Shandong, China.
Xia X; Department of Neurology, Changle People's Hospital, Weifang Shandong, China.
Tao X; Department of Neurology, Changle People's Hospital, Weifang Shandong, China.
Zhao P; Department of Oncology, Changle People's Hospital, Weifang Shandong, China.
Deng C; Department of Neurology, Changle People's Hospital, Weifang Shandong, China.
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Źródło:
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 3934-3946.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Movement*/genetics
Gene Knockdown Techniques*
Wnt Signaling Pathway*
Brain Neoplasms/*enzymology
Brain Neoplasms/*pathology
Glioblastoma/*enzymology
Glioblastoma/*pathology
Sulfotransferases/*deficiency
Brain Neoplasms/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Glioblastoma/genetics ; Humans ; Male ; Middle Aged ; Sulfotransferases/genetics ; Sulfotransferases/metabolism ; Survival Analysis ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł:
Enduring Effects of Conditional Brain Serotonin Knockdown, Followed by Recovery, on Adult Rat Neurogenesis and Behavior.
Autorzy:
Sidorova M; School of Life Sciences, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia.; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
Kronenberg G; Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatrische Universitätsklinik, 8032 Zürich, Switzerland.; Department of Psychiatry and Psychotherapy, Charité University Medicine, 10117 Berlin, Germany.
Matthes S; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
Petermann M; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.; Department of Clinical Pharmacy and Pharmacotherapy, Institute of Pharmacy, Martin Luther University, 06120 Halle, Germany.
Hellweg R; Department of Psychiatry and Psychotherapy, Charité University Medicine, 10117 Berlin, Germany.
Tuchina O; School of Life Sciences, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia.
Bader M; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
Alenina N; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.; Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia.
Klempin F; School of Life Sciences, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia.; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité University Medicine, 10117 Berlin, Germany.
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Źródło:
Cells [Cells] 2021 Nov 19; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Behavior, Animal*
Gene Knockdown Techniques*
Neurogenesis*
Aging/*physiology
Serotonin/*metabolism
Animals ; Cell Count ; Cell Proliferation ; Dentate Gyrus/cytology ; Female ; Phenotype ; Prefrontal Cortex/metabolism ; Raphe Nuclei/metabolism ; Rats, Sprague-Dawley ; Tryptophan Hydroxylase/metabolism
Czasopismo naukowe
Tytuł:
Preventing adolescent synaptic pruning in mouse prelimbic cortex via local knockdown of α4βδ GABA A receptors increases anxiety response in adulthood.
Autorzy:
Evrard MR; Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA.; Graduate Program in Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA.
Li M; Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA.; College of Arts and Sciences, Hunter College, New York, NY, 10065, USA.
Shen H; Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA.; School of Biomedical Engineering, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, 300070, China.
Smith SS; Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Oct 26; Vol. 11 (1), pp. 21059. Date of Electronic Publication: 2021 Oct 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Anxiety*/genetics
Anxiety*/metabolism
Gene Knockdown Techniques*
Neuronal Plasticity*
Sexual Maturation*
Brain/*metabolism
Receptors, GABA-A/*deficiency
Animals ; Female ; Male ; Mice ; Mice, Knockout ; Receptors, GABA-A/metabolism
Czasopismo naukowe
Tytuł:
Knockdown of miR-125b-5p inhibits the proliferation and invasion of gastric carcinoma cells by targeting RYBP.
Autorzy:
Jin FE; Department of Health Management, Qingdao Huangdao District Center Hospital, Qingdao, China.
Xie B; Gastrointestinal Surgery, Liaocheng People's Hospital, Liaocheng, China.
Xian HZ; Department of Gastroenterology, Jimo People's Hospital of Qingdao City, Qingdao, China.
Wang JH; Surgery Staff Room, Shandong Medical College, Linyi, China.
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Źródło:
The Kaohsiung journal of medical sciences [Kaohsiung J Med Sci] 2021 Oct; Vol. 37 (10), pp. 863-871. Date of Electronic Publication: 2021 Aug 01.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Knockdown Techniques*
Cell Proliferation/*genetics
Neoplasm Invasiveness/*pathology
Repressor Proteins/*genetics
Stomach Neoplasms/*genetics
Down-Regulation ; Humans ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology
Czasopismo naukowe
Tytuł:
Tenascin-c knockdown suppresses vasculogenic mimicry of gastric cancer by inhibiting ERK- triggered EMT.
Autorzy:
Kang X; Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, 210008, Nanjing, China.
Xu E; Department of General Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, No. 321 Zhongshan Road, 210008, Nanjing, China.
Wang X; Department of General Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, No. 321 Zhongshan Road, 210008, Nanjing, China.
Qian L; Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, 210008, Nanjing, China.
Yang Z; Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, 210008, Nanjing, China.
Yu H; Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, 210008, Nanjing, China.
Wang C; Department of General Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, No. 321 Zhongshan Road, 210008, Nanjing, China.
Ren C; Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, 210008, Nanjing, China.
Wang Y; Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, 210008, Nanjing, China.
Lu X; Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, 210008, Nanjing, China.; Department of General Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, No. 321 Zhongshan Road, 210008, Nanjing, China.
Xia X; Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, 210008, Nanjing, China. .; Department of General Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, No. 321 Zhongshan Road, 210008, Nanjing, China. .
Guan W; Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, 210008, Nanjing, China. .; Department of General Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, No. 321 Zhongshan Road, 210008, Nanjing, China. .
Qiao T; Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, 210008, Nanjing, China. .; Department of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, 210008, Nanjing, China. .
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Źródło:
Cell death & disease [Cell Death Dis] 2021 Sep 29; Vol. 12 (10), pp. 890. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*
Gene Knockdown Techniques*
Extracellular Signal-Regulated MAP Kinases/*metabolism
Stomach Neoplasms/*pathology
Tenascin/*metabolism
Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Invasiveness ; Peritoneum/pathology ; Phosphorylation ; Prognosis ; Stomach Neoplasms/genetics ; Tenascin/genetics ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł:
Effects of IGFBP3 knockdown on human endometrial mesenchymal stromal cells stress-induced senescence.
Autorzy:
Ushakov RE; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia.
Aksenov ND; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia.
Pugovkina NA; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia.
Burova EB; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Sep 17; Vol. 570, pp. 143-147. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*
Gene Knockdown Techniques*
Stress, Physiological*
Endometrium/*pathology
Insulin-Like Growth Factor Binding Protein 3/*metabolism
Mesenchymal Stem Cells/*metabolism
Cell Line ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Female ; Humans ; Retinoblastoma Protein/metabolism ; Tumor Suppressor Protein p53/metabolism ; Up-Regulation ; beta-Galactosidase/metabolism
Czasopismo naukowe
Tytuł:
GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway.
Autorzy:
Liu HY; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China.
Zhang HS; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China. Electronic address: .
Liu MY; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China.
Li HM; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China.
Wang XY; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China.
Wang M; Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100#, District of Chaoyang, Beijing, 100124, China.
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Źródło:
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Sep 15; Vol. 708, pp. 108964. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Knockdown Techniques*
Autophagy/*genetics
Cell Movement/*genetics
Colorectal Neoplasms/*pathology
Glutaminase/*deficiency
Glutaminase/*genetics
NF-E2-Related Factor 2/*metabolism
Cell Line, Tumor ; Cell Proliferation/genetics ; Humans ; Oxidation-Reduction
Czasopismo naukowe
Tytuł:
Knockdown of ZNF479 inhibits proliferation and glycolysis of gastric cancer cells through regulating β-catenin/c-Myc signaling pathway.
Autorzy:
Jin XS; Department of Gastroenterology, Ruian people's hospital, Rui'an City, China.
Ji TT; Department of Gastroenterology, Ruian people's hospital, Rui'an City, China.
Shi ZC; Department of Gastroenterology, Ruian people's hospital, Rui'an City, China.
Zhang QQ; Department of Gastroenterology, Ruian people's hospital, Rui'an City, China.
Ye FP; Department of Gastroenterology, Ruian people's hospital, Rui'an City, China.
Yu WL; Department of Gastroenterology, Ruian people's hospital, Rui'an City, China.
Li RZ; Department of Gastroenterology, Ruian people's hospital, Rui'an City, China.
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Źródło:
The Kaohsiung journal of medical sciences [Kaohsiung J Med Sci] 2021 Sep; Vol. 37 (9), pp. 759-767. Date of Electronic Publication: 2021 May 27.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Knockdown Techniques*
Signal Transduction*
Cell Proliferation/*genetics
DNA-Binding Proteins/*genetics
Proto-Oncogene Proteins c-myc/*metabolism
Stomach Neoplasms/*pathology
Transcription Factors/*genetics
beta Catenin/*metabolism
Cell Line, Tumor ; Glycolysis ; Humans ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism
Czasopismo naukowe
Tytuł:
Decreasing pdzd8-mediated mito-ER contacts improves organismal fitness and mitigates Aβ 42 toxicity.
Autorzy:
Hewitt VL; Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Neuroscience, Columbia University Medical Center, New York, NY, USA.
Miller-Fleming L; Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Twyning MJ; Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Andreazza S; Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Mattedi F; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, IoPPN, King's College London, London, UK.
Prudent J; Department of Neuroscience, Columbia University Medical Center, New York, NY, USA.
Polleux F; Department of Neuroscience, Columbia University Medical Center, New York, NY, USA.; Mortimer B Zuckerman Mind Brain Behavior Institute, New York, NY, USA.; Kavli Institute for Brain Sciences, Columbia University Medical Center, New York, NY, USA.
Vagnoni A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, IoPPN, King's College London, London, UK.
Whitworth AJ; Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK .
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Źródło:
Life science alliance [Life Sci Alliance] 2022 Jul 13; Vol. 5 (11). Date of Electronic Publication: 2022 Jul 13 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Amyloid beta-Peptides*/antagonists & inhibitors
Amyloid beta-Peptides*/toxicity
Drosophila Proteins*/deficiency
Drosophila Proteins*/genetics
Drosophila Proteins*/metabolism
Drosophila melanogaster*/cytology
Drosophila melanogaster*/drug effects
Drosophila melanogaster*/metabolism
Drosophila melanogaster*/physiology
Endoplasmic Reticulum*/drug effects
Endoplasmic Reticulum*/metabolism
Mitochondria*/drug effects
Mitochondria*/metabolism
Peptide Fragments*/antagonists & inhibitors
Peptide Fragments*/toxicity
Alzheimer Disease ; Animals ; Cellular Senescence ; Disease Models, Animal ; Gene Knockdown Techniques ; Genetic Fitness ; Locomotion/drug effects ; Longevity/drug effects ; Mitochondrial Dynamics/drug effects ; Mitophagy/drug effects ; Neurons/drug effects
Czasopismo naukowe

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