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Tytuł :
Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors.
Autorzy :
Bjaanæs MM; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway. .; Department of Oncology, Oslo University Hospital, 4950 Nydalen, Oslo, Norway. .
Nilsen G; Department of Computer Science, University of Oslo, Oslo, Norway.; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Halvorsen AR; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.
Russnes HG; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Department of Pathology, Oslo University Hospital, Oslo, Norway.
Solberg S; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
Jørgensen L; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
Brustugun OT; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Section of Oncology, Vestre Viken Hospital, Drammen, Norway.
Lingjærde OC; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Department of Computer Science, University of Oslo, Oslo, Norway.; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Helland Å; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Department of Oncology, Oslo University Hospital, 4950 Nydalen, Oslo, Norway.
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Źródło :
BMC cancer [BMC Cancer] 2021 Oct 09; Vol. 21 (1), pp. 1089. Date of Electronic Publication: 2021 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Dosage*
Genes, p53*
Adenocarcinoma of Lung/*genetics
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Adenocarcinoma of Lung/pathology ; Alleles ; Carcinoma, Non-Small-Cell Lung/pathology ; Chromosomes, Human, Pair 7 ; Chromosomes, Human, Pair 9 ; Class I Phosphatidylinositol 3-Kinases/genetics ; DNA Copy Number Variations ; Ex-Smokers ; Female ; Gene Expression ; Genes, erbB-1/genetics ; Genes, ras/genetics ; Humans ; Lung Neoplasms/pathology ; Male ; Non-Smokers ; Polymorphism, Single Nucleotide ; Signal Transduction/genetics ; Smokers ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
Hox11 expression characterizes developing zeugopod synovial joints and is coupled to postnatal articular cartilage morphogenesis into functional zones in mice.
Autorzy :
Rux D; Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: .
Helbig K; Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Koyama E; Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Pacifici M; Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
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Źródło :
Developmental biology [Dev Biol] 2021 Sep; Vol. 477, pp. 49-63. Date of Electronic Publication: 2021 May 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genes, Homeobox*
Cartilage, Articular/*embryology
Chondrogenesis/*genetics
Synovial Membrane/*embryology
Animals ; Chondrogenesis/physiology ; Extremities/embryology ; Gene Expression Regulation, Developmental ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Mice
Czasopismo naukowe
Tytuł :
Family trio-based sequencing in 404 sporadic bilateral hearing loss patients discovers recessive and De novo genetic variants in multiple ways.
Autorzy :
Guan J; College of Otolaryngology Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China; National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, China & Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, 100853, China. Electronic address: .
Li J; College of Otolaryngology Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China; National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, China & Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, 100853, China. Electronic address: .
Chen G; College of Otolaryngology Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China; National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, China & Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, 100853, China. Electronic address: .
Shi T; College of Otolaryngology Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China; National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, China & Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, 100853, China. Electronic address: .
Lan L; College of Otolaryngology Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China; National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, China & Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, 100853, China. Electronic address: .
Wu X; College of Otolaryngology Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China; National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, China & Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, 100853, China. Electronic address: .
Zhao C; College of Otolaryngology Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China; National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, China & Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, 100853, China. Electronic address: .
Wang D; College of Otolaryngology Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China; National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, China & Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, 100853, China. Electronic address: .
Wang H; College of Otolaryngology Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China; National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, China & Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, 100853, China. Electronic address: .
Wang Q; College of Otolaryngology Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China; National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, China & Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, 100853, China. Electronic address: .
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Źródło :
European journal of medical genetics [Eur J Med Genet] 2021 Oct; Vol. 64 (10), pp. 104311. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Recessive*
Mutation*
Hearing Loss, Sensorineural/*genetics
Adolescent ; Adult ; DNA Copy Number Variations ; Female ; Gene Frequency ; Genes, Dominant ; Genetic Testing/methods ; Genetic Testing/statistics & numerical data ; Humans ; Male ; Pedigree
Czasopismo naukowe
Tytuł :
FunOrder: A robust and semi-automated method for the identification of essential biosynthetic genes through computational molecular co-evolution.
Autorzy :
Vignolle GA; Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.
Schaffer D; Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.
Zehetner L; Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.
Mach RL; Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.
Mach-Aigner AR; Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.
Derntl C; Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2021 Sep 27; Vol. 17 (9), pp. e1009372. Date of Electronic Publication: 2021 Sep 27 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Evolution, Molecular*
Genes, Essential*
Multigene Family*
Software*
Biosynthetic Pathways/*genetics
Aspergillus/genetics ; Aspergillus/metabolism ; Computational Biology ; Databases, Protein ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Fungi/genetics ; Fungi/metabolism ; Genes, Synthetic ; Genome, Fungal ; Genomics ; Lovastatin/biosynthesis ; Lovastatin/genetics ; Phylogeny ; Proteome/genetics
SCR Organism :
Aspergillus terreus
Czasopismo naukowe
Tytuł :
Increased gene expression variability in BRCA1-associated and basal-like breast tumours.
Autorzy :
Wiggins GAR; Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Black MA; Department of Biochemistry, University of Otago, Dunedin, New Zealand.
Dunbier A; Department of Biochemistry, University of Otago, Dunedin, New Zealand.
Morley-Bunker AE; Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Pearson JF; Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.; Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand.
Walker LC; Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand. .
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Corporate Authors :
kConFab Investigators
Źródło :
Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Sep; Vol. 189 (2), pp. 363-375. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/genetics
Genes, BRCA1*
BRCA1 Protein/genetics ; Female ; Gene Expression ; Gene Expression Profiling ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Humans
Czasopismo naukowe
Tytuł :
Network topology analysis of essential genes interactome of Helicobacter pylori to explore novel therapeutic targets.
Autorzy :
Gollapalli P; Central Research Laboratory, K. S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, 575018, Karnataka, India. Electronic address: .
G TS; Central Research Laboratory, K. S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, 575018, Karnataka, India.
H M; Department of Biochemistry, Jnana Bharathi Campus, Bangalore University, Bangalore, Karnataka, 560056, India.
Shetty P; Central Research Laboratory, K. S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, 575018, Karnataka, India.
N SK; Central Research Laboratory, K. S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, 575018, Karnataka, India.
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Źródło :
Microbial pathogenesis [Microb Pathog] 2021 Sep; Vol. 158, pp. 105059. Date of Electronic Publication: 2021 Jun 19.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Essential*
Helicobacter pylori*/genetics
Computational Biology ; Gene Ontology ; Genes, Bacterial ; Protein Interaction Maps
Czasopismo naukowe
Tytuł :
A genome-wide identification and analysis of the homeobox genes in the brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae).
Autorzy :
Fu SJ; Department of Agriculture and Biotechnology, State Key Laboratory of Rice Biology, Zhejiang University, Hangzhou, Zhejiang, China.
Zhang JL; Department of Agriculture and Biotechnology, State Key Laboratory of Rice Biology, Zhejiang University, Hangzhou, Zhejiang, China.
Xu HJ; Department of Agriculture and Biotechnology, State Key Laboratory of Rice Biology, Zhejiang University, Hangzhou, Zhejiang, China.; Department of Agriculture and Biotechnology, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, Zhejiang, China.; Department of Agriculture and Biotechnology, Institute of Insect Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
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Źródło :
Archives of insect biochemistry and physiology [Arch Insect Biochem Physiol] 2021 Sep; Vol. 108 (1), pp. e21833. Date of Electronic Publication: 2021 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Homeobox*
Fertility/*genetics
Hemiptera/*genetics
Animals ; Gene Expression Profiling/methods ; Genes, Insect ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Nymph/genetics ; Pest Control ; RNA Interference ; Reproduction/genetics
Czasopismo naukowe
Tytuł :
Decision aids for female BRCA mutation carriers: a scoping review protocol.
Autorzy :
McGarrigle SA; Faculty of Health Sciences, Trinity College Dublin, Dublin, Ireland.
Prizeman G; Trinity Centre for Practice and Healthcare Innovation, School of Nursing & Midwifery, Trinity College Dublin, Dublin, Ireland.
Spillane C; Breast Care Department, St. James's Hospital, Dublin, Ireland.
Byrne N; Breast Care Department, St. James's Hospital, Dublin, Ireland.
Drury A; School of Nursing, Midwifery and Health Systems, University College Dublin, Dublin, Ireland.; School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland.
Mockler D; John Stearne Library, Trinity College Dublin, Dublin, Ireland.
Connolly EM; Breast Care Department, St. James's Hospital, Dublin, Ireland.; Department of Surgery, Trinity College Dublin, Dublin, Ireland.
Brady AM; Trinity Centre for Practice and Healthcare Innovation, School of Nursing & Midwifery, Trinity College Dublin, Dublin, Ireland.
Hanhauser YP; School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland .
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Źródło :
BMJ open [BMJ Open] 2021 Jul 12; Vol. 11 (7), pp. e045075. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, BRCA2*
Ovarian Neoplasms*/genetics
Decision Support Techniques ; Female ; Genes, BRCA1 ; Humans ; Mutation ; Research Design ; Review Literature as Topic ; Systematic Reviews as Topic
Czasopismo naukowe
Tytuł :
High promoter sequence variation in subgroup 6 members of R2R3-MYB genes is involved in different floral anthocyanin color patterns in Lilium spp.
Autorzy :
Yamagishi M; Research Faculty of Agriculture, Hokkaido University, N9W9, Kita-ku, Sapporo, 060-8589, Japan. .
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Źródło :
Molecular genetics and genomics : MGG [Mol Genet Genomics] 2021 Jul; Vol. 296 (4), pp. 1005-1015. Date of Electronic Publication: 2021 May 30.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, myb*/genetics
Lilium*/genetics
Lilium*/metabolism
Anthocyanins/*biosynthesis
Pigmentation/*genetics
Anthocyanins/genetics ; Flowers/genetics ; Flowers/metabolism ; Genes, Plant ; Genetic Variation ; Multigene Family/genetics ; Mutation Rate ; Plant Proteins/genetics ; Plants, Genetically Modified ; Promoter Regions, Genetic/genetics ; Sequence Analysis, DNA ; Tobacco/genetics ; Tobacco/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł :
Simultaneous targeting of duplicated genes in Petunia protoplasts for flower color modification via CRISPR-Cas9 ribonucleoproteins.
Autorzy :
Yu J; Department of Chemistry, Hanyang University, Seoul, 04763, South Korea.; Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul, 04763, South Korea.
Tu L; Department of Horticulture & Department of Smart Agriculture systems, Chungnam National University, Daejeon, 34134, South Korea.
Subburaj S; Department of Horticulture & Department of Smart Agriculture systems, Chungnam National University, Daejeon, 34134, South Korea.
Bae S; Department of Chemistry, Hanyang University, Seoul, 04763, South Korea. .; Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul, 04763, South Korea. .
Lee GJ; Department of Horticulture & Department of Smart Agriculture systems, Chungnam National University, Daejeon, 34134, South Korea. .
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Źródło :
Plant cell reports [Plant Cell Rep] 2021 Jun; Vol. 40 (6), pp. 1037-1045. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
CRISPR-Cas Systems*
Genes, Duplicate*
Gene Knockout Techniques/*methods
Petunia/*genetics
Pigmentation/*genetics
CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/isolation & purification ; Gene Editing/methods ; Genes, Plant ; Mutagenesis, Site-Directed ; Petunia/physiology ; Plants, Genetically Modified/genetics ; Protoplasts/cytology ; Protoplasts/physiology ; RNA, Guide ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism
Czasopismo naukowe
Tytuł :
Position preference of essential genes in prokaryotic operons.
Autorzy :
Liu T; Department of Physics, School of Science, Tianjin University, Tianjin, China.
Luo H; Department of Physics, School of Science, Tianjin University, Tianjin, China.
Gao F; Department of Physics, School of Science, Tianjin University, Tianjin, China.; Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, China.; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China.
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Źródło :
PloS one [PLoS One] 2021 Apr 22; Vol. 16 (4), pp. e0250380. Date of Electronic Publication: 2021 Apr 22 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Archaeal*
Genes, Bacterial*
Operon*
Archaea/*genetics
Bacteria/*genetics
Computational Biology/methods ; Databases, Genetic ; Genes, Essential
Czasopismo naukowe
Tytuł :
Comparison of Brassica Genomes reveals asymmetrical gene retention between functional groups of genes in recurrent polyploidizations.
Autorzy :
Zhang H; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, 518083, China.; BGI-Shenzhen, Shenzhen, 518083, China.
Xie J; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, 518083, China.; BGI-Shenzhen, Shenzhen, 518083, China.
Wang W; College of Life Sciences, Wuhan University, Wuhan, 430072, China. .
Wang J; College of Life Sciences, Wuhan University, Wuhan, 430072, China. .
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Źródło :
Plant molecular biology [Plant Mol Biol] 2021 May; Vol. 106 (1-2), pp. 193-206. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Genes, Plant*
Polyploidy*
Brassica/*genetics
Arabidopsis/genetics ; Base Sequence ; Diploidy ; Evolution, Molecular ; Gene Dosage ; Gene Expression Regulation, Plant ; Genes, Duplicate ; Phylogeny ; Selection, Genetic ; Synteny/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats.
Autorzy :
de Luzy IR; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Law KCL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Moriarty N; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Hunt CPJ; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Durnall JC; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Thompson LH; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Nagy A; Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC, Australia.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Parish CL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia. .
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Źródło :
Nature communications [Nat Commun] 2021 May 27; Vol. 12 (1), pp. 3275. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Transgenic, Suicide*
Cell Engineering/*methods
Parkinson Disease, Secondary/*therapy
Stem Cell Transplantation/*methods
Animals ; Apoptosis/genetics ; Cell Differentiation ; Cell Line ; Cell Proliferation/genetics ; Disease Models, Animal ; Dopaminergic Neurons/physiology ; Female ; Genes, bcl-1/genetics ; Heterografts/cytology ; Heterografts/pathology ; Human Embryonic Stem Cells/physiology ; Humans ; Male ; Mesencephalon/cytology ; Mesencephalon/pathology ; Oxidopamine/administration & dosage ; Oxidopamine/toxicity ; Parkinson Disease, Secondary/chemically induced ; Parkinson Disease, Secondary/pathology ; Rats ; Stem Cell Transplantation/adverse effects ; Stem Cell Transplantation/standards ; Thymidine Kinase/genetics
Czasopismo naukowe
Tytuł :
Molecular pathogenesis of breast cancer: impact of miR-99a-5p and miR-99a-3p regulation on oncogenic genes.
Autorzy :
Shinden Y; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Hirashima T; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Nohata N; MSD K.K., Tokyo, Japan.
Toda H; Department of Breast Surgery, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan.
Okada R; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, 260-8670, Japan.
Asai S; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, 260-8670, Japan.
Tanaka T; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Hozaka Y; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Ohtsuka T; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Kijima Y; Department of Breast Surgery, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan.
Seki N; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, 260-8670, Japan. .
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Źródło :
Journal of human genetics [J Hum Genet] 2021 May; Vol. 66 (5), pp. 519-534. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Estrogens*
Genes, Tumor Suppressor*
Oncogenes*
Progesterone*
Breast Neoplasms/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Intracellular Signaling Peptides and Proteins/*genetics
MicroRNAs/*genetics
Neoplasm Proteins/*genetics
Neoplasms, Hormone-Dependent/*genetics
Nuclear Proteins/*genetics
RNA, Neoplasm/*genetics
Aminopyridines/administration & dosage ; Aminopyridines/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Benzimidazoles/administration & dosage ; Benzimidazoles/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Down-Regulation ; Female ; Genes, erbB-2 ; Humans ; Intracellular Signaling Peptides and Proteins/biosynthesis ; Intracellular Signaling Peptides and Proteins/physiology ; Kaplan-Meier Estimate ; MicroRNAs/physiology ; Middle Aged ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/physiology ; Neoplasms, Hormone-Dependent/drug therapy ; Neoplasms, Hormone-Dependent/mortality ; Neoplasms, Hormone-Dependent/pathology ; Nuclear Proteins/biosynthesis ; Nuclear Proteins/physiology ; Piperazines/administration & dosage ; Piperazines/therapeutic use ; Prognosis ; Progression-Free Survival ; Pyridines/administration & dosage ; Pyridines/therapeutic use ; RNA Interference ; RNA, Neoplasm/physiology ; RNA, Small Interfering/genetics ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Oncogenic KRAS-expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice.
Autorzy :
Kasuga A; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Semba T; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.; Department of Thoracic Surgery, Kumamoto University, Kumamoto, Japan.
Sato R; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.; Department of Respiratory Medicine, Kumamoto University, Kumamoto, Japan.
Nobusue H; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Sugihara E; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.; Research and Development Center for Precision Medicine, University of Tsukuba, Ibaraki, Japan.
Takaishi H; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Kanai T; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Saya H; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Arima Y; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 May; Vol. 112 (5), pp. 1822-1838. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, ras*
Organoids*/metabolism
Organoids*/pathology
Biliary Tract Neoplasms/*genetics
Cholangiocarcinoma/*genetics
Epithelial Cells/*physiology
Stem Cells/*physiology
ADP-Ribosylation Factor 1/genetics ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Animals ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/pathology ; Bile Ducts, Extrahepatic/anatomy & histology ; Bile Ducts, Extrahepatic/cytology ; Bile Ducts, Intrahepatic/cytology ; Biliary Tract Neoplasms/pathology ; Cholangiocarcinoma/pathology ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Disease Models, Animal ; Epithelial Cell Adhesion Molecule ; Epithelial Cells/chemistry ; Epithelial-Mesenchymal Transition ; Female ; Gallbladder/anatomy & histology ; Gallbladder/cytology ; Gallbladder Neoplasms/genetics ; Gallbladder Neoplasms/pathology ; Gene Deletion ; Genes, Tumor Suppressor ; Liver/anatomy & histology ; Mice ; Mice, Inbred C57BL ; Neoplasm Transplantation/methods ; Proto-Oncogene Proteins p21(ras)/metabolism ; Tissue Array Analysis/methods ; Tumor Microenvironment/physiology
Czasopismo naukowe
Tytuł :
Identification of homozygous haplotypes carrying putative recessive lethal mutations that compromise fertility traits in French Lacaune dairy sheep.
Autorzy :
Ben Braiek M; GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet-Tolosan, France.
Fabre S; GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet-Tolosan, France. .
Hozé C; Allice, 149 rue de Bercy, 75595, Paris, France.
Astruc JM; Institut de l'Elevage, 24 chemin de Borde-Rouge, 31326, Castanet-Tolosan, France.
Moreno-Romieux C; GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet-Tolosan, France.
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Źródło :
Genetics, selection, evolution : GSE [Genet Sel Evol] 2021 May 01; Vol. 53 (1), pp. 41. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Lethal*
Haplotypes*
Fertility/*genetics
Sheep/*genetics
Animals ; Genes, Recessive ; Homozygote ; Models, Genetic ; Polymorphism, Single Nucleotide ; Selective Breeding ; Sheep/physiology
Czasopismo naukowe
Tytuł :
A SNP of HD-ZIP I transcription factor leads to distortion of trichome morphology in cucumber (Cucumis sativus L.).
Autorzy :
Zhang L; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Lv D; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Pan J; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Zhang K; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Wen H; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Chen Y; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Du H; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
He H; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Cai R; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.; State Key Laboratory of Vegetable Germplasm Innovation, Tianjin, 300384, China.
Pan J; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China. .
Wang G; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China. .
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Źródło :
BMC plant biology [BMC Plant Biol] 2021 Apr 16; Vol. 21 (1), pp. 182. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Plant*
Polymorphism, Single Nucleotide*
Cucumis sativus/*genetics
Plant Proteins/*genetics
Transcription Factors/*genetics
Trichomes/*anatomy & histology
Cucumis sativus/anatomy & histology ; Genes, Recessive ; Plant Proteins/metabolism ; Transcription Factors/metabolism ; Trichomes/genetics
Czasopismo naukowe
Tytuł :
Establishment of a firefly luciferase reporter assay system in the unicellular red alga Cyanidioschyzon merolae.
Autorzy :
Zhou B; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology.; School of Life Science and Technology, Tokyo Institute of Technology.
Takahashi S; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology.; Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology.
Takemura T; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology.; School of Life Science and Technology, Tokyo Institute of Technology.
Tanaka K; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology.
Imamura S; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology.
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Źródło :
The Journal of general and applied microbiology [J Gen Appl Microbiol] 2021 Apr 16; Vol. 67 (1), pp. 42-46. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Reporter*
Luciferases, Firefly/*genetics
Luciferases, Firefly/*metabolism
Rhodophyta/*enzymology
Rhodophyta/*genetics
Gene Expression Regulation, Plant ; Genes, Plant/genetics ; Nitrite Reductases ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Promoter Regions, Genetic ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Robust and flexible platform for directed evolution of yeast genetic switches.
Autorzy :
Tominaga M; Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Japan.
Nozaki K; Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Japan.
Umeno D; Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Chiba University, Chiba, Japan.
Ishii J; Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Japan. .; Engineering Biology Research Center, Kobe University, Kobe, Japan. .
Kondo A; Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Japan.; Engineering Biology Research Center, Kobe University, Kobe, Japan.; Department of Chemical Science and Engineering, Faculty of Engineering, Kobe University, Kobe, Japan.; Center for Sustainable Resource Science, RIKEN, Yokohama, Japan.
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Źródło :
Nature communications [Nat Commun] 2021 Mar 23; Vol. 12 (1), pp. 1846. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Switch*
Genetic Techniques*
Directed Molecular Evolution/*methods
Genetic Engineering/*methods
Saccharomyces cerevisiae/*genetics
Synthetic Biology/*methods
Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Basidiomycota/genetics ; Basidiomycota/metabolism ; Flow Cytometry ; Gene Library ; Genes, Reporter ; Phloroglucinol/analogs & derivatives ; Phloroglucinol/pharmacology ; Promoter Regions, Genetic ; Repressor Proteins/chemistry ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Signal-To-Noise Ratio ; Tetracycline/pharmacology ; Trans-Activators/chemistry ; Trans-Activators/genetics ; Trans-Activators/metabolism ; beta Carotene/biosynthesis ; beta Carotene/genetics ; beta Carotene/metabolism
SCR Organism :
Phaffia rhodozyma
Czasopismo naukowe
Tytuł :
Genome-wide characterization and expression analysis of pseudo-response regulator gene family in wheat.
Autorzy :
Errum A; Pakistan Agriculture Research Council Institute of Advanced Studies in Agriculture, Islamabad, Pakistan.
Rehman N; National Institute of Genomics and Advanced Biotechnology, National Agriculture Research Center, Islamabad, Pakistan. .; Pakistan Agriculture Research Council Institute of Advanced Studies in Agriculture, Islamabad, Pakistan. .
Khan MR; National Institute of Genomics and Advanced Biotechnology, National Agriculture Research Center, Islamabad, Pakistan. .; Pakistan Agriculture Research Council Institute of Advanced Studies in Agriculture, Islamabad, Pakistan. .
Ali GM; National Institute of Genomics and Advanced Biotechnology, National Agriculture Research Center, Islamabad, Pakistan.; Pakistan Agriculture Research Council Institute of Advanced Studies in Agriculture, Islamabad, Pakistan.
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Źródło :
Molecular biology reports [Mol Biol Rep] 2021 Mar; Vol. 48 (3), pp. 2411-2427. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Plant*
Genes, Regulator*
Genome, Plant*
Multigene Family*
Triticum/*genetics
Amino Acid Motifs ; Amino Acid Sequence ; Base Pairing/genetics ; Chromosomes, Plant/genetics ; Conserved Sequence ; Exons/genetics ; Genes, Plant ; Introns/genetics ; Organ Specificity/genetics ; Phylogeny ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Synteny/genetics
Czasopismo naukowe

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