Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Genes, BRCA1"" wg kryterium: Temat


Tytuł :
Polymorphism in DNA repair gene BRCA1 associated with clinical mastitis and production traits in indigenous dairy cattle.
Autorzy :
Magotra A; Department of Animal Genetics and Breeding, Lala Lajpat Rai University of Veterinary and Animal Sciences (LUVAS), Hisar, India. Electronic address: .
Gupta ID; Dairy Cattle Breeding Division, ICAR- National Dairy Research Institute, 132001, Haryana, India.
Ahmad T; Department of Animal Genetics and Breeding SKAUST-Kashmir, Jammu and Kashmir, India.
Alex R; Dairy Cattle Breeding Division, ICAR- National Dairy Research Institute, 132001, Haryana, India.
Pokaż więcej
Źródło :
Research in veterinary science [Res Vet Sci] 2020 Dec; Vol. 133, pp. 194-201. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, BRCA1*
Polymorphism, Single Nucleotide*
Lactation/*genetics
Mastitis, Bovine/*genetics
Animals ; Cattle ; Female ; Genotype ; Phenotype
Czasopismo naukowe
Tytuł :
[New drug approval: Olaparib - pancreatic cancer with BRCA germline mutation].
Autorzy :
Hilmi M; Université de Versailles Saint-Quentin, institut Curie, département d'oncologie médicale, 35, rue Dailly, 92210 Saint-Cloud, France. Electronic address: .
Neuzillet C; Université de Versailles Saint-Quentin, institut Curie, département d'oncologie médicale, 35, rue Dailly, 92210 Saint-Cloud, France.
Pokaż więcej
Transliterated Title :
Nouvelle AMM : olaparib — cancer du pancréas avec mutation germinale de BRCA.
Źródło :
Bulletin du cancer [Bull Cancer] 2020 Oct; Vol. 107 (10), pp. 961-962. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Letter
MeSH Terms :
Genes, BRCA1*
Genes, BRCA2*
Carcinoma, Pancreatic Ductal/*secondary
Pancreatic Neoplasms/*drug therapy
Phthalazines/*therapeutic use
Piperazines/*therapeutic use
Poly(ADP-ribose) Polymerase Inhibitors/*therapeutic use
Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/genetics ; Clinical Trials, Phase III as Topic ; Drug Approval ; Fatigue/chemically induced ; Female ; Germ-Line Mutation ; Humans ; Male ; Multicenter Studies as Topic ; Pancreatic Neoplasms/genetics ; Phthalazines/adverse effects ; Piperazines/adverse effects ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Treatment Outcome
Opinia redakcyjna
Tytuł :
Comparison of clinical features and oncologic outcomes between familial non-hereditary and hereditary breast cancer in Korean female patients.
Autorzy :
Park CS; Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Park HY; Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; Joint Institute for Regenerative Medicine, Kyungpook National University, Republic of Korea.
Jung JH; Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kim WW; Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Chae YS; Department of Hemato-oncology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Lee SJ; Department of Hemato-oncology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Park JY; Department of Pathology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Park JY; Department of Pathology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Lee J; Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło :
Asian journal of surgery [Asian J Surg] 2020 Oct; Vol. 43 (10), pp. 996-1001. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Genes, BRCA1*
Genes, BRCA2*
Medical History Taking*
Mutation*
Breast Neoplasms/*genetics
Genetic Diseases, Inborn/*genetics
Adult ; Aged ; Asian Continental Ancestry Group ; Female ; Humans ; Middle Aged ; Prognosis
Czasopismo naukowe
Tytuł :
Chemotherapy directly followed by poly(ADP-ribose) polymerase inhibition as an alternative to surgery in patients with BRCA-mutated ovarian cancer: a potential management strategy in the era of coronavirus disease 2019.
Autorzy :
Vetter MH; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, 320 W 10 Ave., M210 Starling Loving Hall, Columbus, OH 43210. Electronic address: .
Smrz SA; Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH.
Copeland LJ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, OH.
Cohn DE; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, OH.
Pokaż więcej
Źródło :
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2020 Sep; Vol. 223 (3), pp. 469-470. Date of Electronic Publication: 2020 May 23.
Typ publikacji :
Letter
MeSH Terms :
Betacoronavirus*
Genes, BRCA1*
Genes, BRCA2*
Mutation*
Antineoplastic Agents/*therapeutic use
Carcinoma, Ovarian Epithelial/*drug therapy
Coronavirus Infections/*epidemiology
Ovarian Neoplasms/*drug therapy
Pneumonia, Viral/*epidemiology
Poly(ADP-ribose) Polymerase Inhibitors/*therapeutic use
COVID-19 ; Carcinoma, Ovarian Epithelial/genetics ; Female ; Humans ; Ovarian Neoplasms/genetics ; Pandemics ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
Screening of BRCA1/2 genes mutations and copy number variations in patients with high risk for hereditary breast and ovarian cancer syndrome (HBOC).
Autorzy :
El Ansari FZ; Biomedical Genomics and Oncogenetics Research Laboratory, Faculty of Sciences and Techniques of Tangier, University Abdelmalek Essaâdi, 90000, Tangier, Morocco. .; Molecular Biology Department, ANOUAL Laboratory, Casablanca, Morocco. .
Jouali F; Molecular Biology Department, ANOUAL Laboratory, Casablanca, Morocco.
Marchoudi N; Molecular Biology Department, ANOUAL Laboratory, Casablanca, Morocco.
Bennani MM; Biomedical Genomics and Oncogenetics Research Laboratory, Faculty of Sciences and Techniques of Tangier, University Abdelmalek Essaâdi, 90000, Tangier, Morocco.
Ghailani NN; Biomedical Genomics and Oncogenetics Research Laboratory, Faculty of Sciences and Techniques of Tangier, University Abdelmalek Essaâdi, 90000, Tangier, Morocco.
Barakat A; Biomedical Genomics and Oncogenetics Research Laboratory, Faculty of Sciences and Techniques of Tangier, University Abdelmalek Essaâdi, 90000, Tangier, Morocco.
Fekkak J; Molecular Biology Department, ANOUAL Laboratory, Casablanca, Morocco.
Pokaż więcej
Źródło :
BMC cancer [BMC Cancer] 2020 Aug 10; Vol. 20 (1), pp. 747. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Copy Number Variations*
Genes, BRCA1*
Genes, BRCA2*
Mutation*
Hereditary Breast and Ovarian Cancer Syndrome/*genetics
Adult ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Middle Aged ; Morocco ; Young Adult
Czasopismo naukowe
Tytuł :
Salvage lymphadenectomy in recurrent ovarian cancer patients: Analysis of clinical outcome and BRCA1/2 gene mutational status.
Autorzy :
Gallotta V; Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC di Ginecologia Oncologica, Roma, Italy. Electronic address: .
Bruno M; Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC di Ginecologia Oncologica, Roma, Italy; Università Cattolica Del Sacro Cuore, Roma, Italy.
Conte C; Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC di Ginecologia Oncologica, Roma, Italy.
Giudice MT; Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC di Ginecologia Oncologica, Roma, Italy; Università Cattolica Del Sacro Cuore, Roma, Italy.
Davià F; Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC di Ginecologia Oncologica, Roma, Italy; Università Cattolica Del Sacro Cuore, Roma, Italy.
Moro F; Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC di Ginecologia Oncologica, Roma, Italy.
Zannoni GF; Università Cattolica Del Sacro Cuore, Roma, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Gineco-patologia e Patologia Mammaria, Roma, Italy.
Fagotti A; Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC di Ginecologia Oncologica, Roma, Italy; Università Cattolica Del Sacro Cuore, Roma, Italy.
De Bonis M; Fondazione Policlinico Universitario A. Gemelli IRCCS, Polo Scienze per Immagini, di Laboratorio e Infettivologiche, Roma, Italy.
Capoluongo E; Università Federico II-CEINGE, Biotecnologie Avanzate, Napoli, Italy.
Scambia G; Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC di Ginecologia Oncologica, Roma, Italy; Università Cattolica Del Sacro Cuore, Roma, Italy.
Ferrandina G; Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC di Ginecologia Oncologica, Roma, Italy; Università Cattolica Del Sacro Cuore, Roma, Italy.
Pokaż więcej
Źródło :
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2020 Jul; Vol. 46 (7), pp. 1327-1333. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, BRCA1*
Genes, BRCA2*
Lymph Node Excision*
Carcinoma, Ovarian Epithelial/*surgery
Neoplasm Recurrence, Local/*surgery
Ovarian Neoplasms/*surgery
Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; CA-125 Antigen/blood ; Carcinoma, Ovarian Epithelial/drug therapy ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/secondary ; Chemotherapy, Adjuvant ; Cytoreduction Surgical Procedures ; Female ; Follow-Up Studies ; Humans ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Membrane Proteins/blood ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Platinum Compounds/administration & dosage ; Poly(ADP-ribose) Polymerase Inhibitors/administration & dosage ; Progression-Free Survival ; Retrospective Studies ; Salvage Therapy ; Time Factors ; Tumor Burden
Czasopismo naukowe
Tytuł :
Effects of BRCA gene mutation on female reproductive potential: A systematic review.
Autorzy :
Hu KL; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China. Electronic address: .
Wang S; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China. Electronic address: .
Ye X; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China. Electronic address: .
Zhang D; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China. Electronic address: .
Pokaż więcej
Źródło :
Maturitas [Maturitas] 2020 Jul; Vol. 137, pp. 11-17. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Genes, BRCA1*
Genes, BRCA2*
Reproductive Physiological Phenomena/*genetics
Anti-Mullerian Hormone/blood ; Female ; Humans ; Menopause/genetics ; Mutation ; Ovarian Follicle ; Ovarian Reserve/genetics ; Parity/genetics
Czasopismo naukowe
Tytuł :
Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline.
Autorzy :
Tung NM; Beth Israel Deaconess Medical Center, Boston, MA.
Boughey JC; Mayo Clinic, Rochester, MN.
Pierce LJ; Rogel Cancer Center, University of Michigan, Ann Arbor, MI.
Robson ME; Memorial Sloan Kettering Cancer Center, New York, NY.
Bedrosian I; The University of Texas MD Anderson Cancer Center, Houston, TX.
Dietz JR; Case Western Reserve University School of Medicine and University Hospitals, Cleveland, OH.
Dragun A; MD Anderson-Cooper University Hospital, Camden, NJ.
Gelpi JB; Vall d'Hebron University Hospital, Barcelona, Spain.
Hofstatter EW; Yale Cancer Center, New Haven, CT.
Isaacs CJ; Georgetown University, Washington, DC.
Jatoi I; University of Texas Health Science Center at San Antonio, San Antonio, TX.
Kennedy E; FORCE, Washington, DC.
Litton JK; The University of Texas MD Anderson Cancer Center, Houston, TX.
Mayr NA; University of Washington, Seattle, WA.
Qamar RD; Advocate Aurora Health, Milwaukee, WI.
Trombetta MG; Allegheny Health Network, Pittsburgh, PA.
Harvey BE; American Society of Clinical Oncology, Alexandria, VA.
Somerfield MR; American Society of Clinical Oncology, Alexandria, VA.
Zakalik D; Beaumont Health, Royal Oak, MI.
Pokaż więcej
Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2020 Jun 20; Vol. 38 (18), pp. 2080-2106. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, BRCA1*
Genes, BRCA2*
Mutation*
Practice Guidelines as Topic*
Breast Neoplasms/*therapy
Breast Neoplasms/genetics ; Female ; Humans ; Medical Oncology ; Radiation Oncology ; Societies, Medical ; Surgical Oncology
SCR Disease Name :
Breast Cancer, Familial
Czasopismo naukowe
Tytuł :
Managing a woman with BRCA mutations? Shared decision-making is key.
Autorzy :
Schrager S; University of Wisconsin Department of Family Medicine and Community Health, Madison, USA. Email: .
Torell E; Indian Health Board, Minneapolis, MN, USA.
Ledford K; Group Health of Wisconsin, Madison, USA.
Elezaby M; University of Wisconsin Department of Radiology, Madison, USA.
Barroleit L; University of Wisconsin Department of Obstetrics and Gynecology, Madison, USA.
Sadowski E; University of Wisconsin Department of Radiology, Madison, USA.
Pokaż więcej
Źródło :
The Journal of family practice [J Fam Pract] 2020 Jun; Vol. 69 (5), pp. 237-243.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Decision Making, Shared*
Genes, BRCA1*
Genes, BRCA2*
Breast Neoplasms/*prevention & control
Mutation/*genetics
Ovarian Neoplasms/*prevention & control
Adult ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Female ; Genetic Testing ; Humans ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Ovarian Cancer After Prophylactic Salpingectomy in a Patient With Germline BRCA1 Mutation.
Autorzy :
Lugo Santiago N; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York; Atlantic Health System, Morristown, New Jersey; Obafemi Awolowo University, Ile-Ife, Nigeria; and the Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, New York.
Smith E
Cox M
Wan CS
Tchabo NE
Awowole I
Broach V
Chi DS
Pokaż więcej
Źródło :
Obstetrics and gynecology [Obstet Gynecol] 2020 Jun; Vol. 135 (6), pp. 1270-1274.
Typ publikacji :
Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Genes, BRCA1*
Carcinoma, Ovarian Epithelial/*diagnosis
Ovarian Neoplasms/*diagnosis
Adult ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/surgery ; Clinical Trials as Topic ; Female ; Genetic Predisposition to Disease ; Germ-Line Mutation ; Humans ; Mastectomy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/surgery ; Ovariectomy ; Salpingectomy ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
Olaparib monotherapy for Asian patients with a germline BRCA mutation and HER2-negative metastatic breast cancer: OlympiAD randomized trial subgroup analysis.
Autorzy :
Im SA; Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. .
Xu B; National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Li W; The First Hospital of Jilin University, Changchun, China.
Robson M; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ouyang Q; Medical Oncology Center, Hunan Tumor Hospital, Changsha, China.
Yeh DC; Cheng Ching Hospital, Taichung City, Taiwan.
Iwata H; Department of Breast Oncology, Aichi Cancer Center Hospital, Aichi, Japan.
Park YH; Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Sohn JH; Yonsei University College of Medicine, Seoul, Korea.
Tseng LM; Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
Goessl C; AstraZeneca, Gaithersburg, MD, USA.
Wu W; AstraZeneca, Gaithersburg, MD, USA.
Masuda N; National Hospital Organization, Osaka National Hospital, Osaka, Japan.
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2020 May 29; Vol. 10 (1), pp. 8753. Date of Electronic Publication: 2020 May 29.
Typ publikacji :
Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, BRCA1*
Genes, BRCA2*
Antineoplastic Agents/*therapeutic use
Breast Neoplasms/*drug therapy
Carcinoma/*secondary
Phthalazines/*therapeutic use
Piperazines/*therapeutic use
Poly(ADP-ribose) Polymerase Inhibitors/*therapeutic use
Adult ; Aged ; Asian Continental Ancestry Group ; Breast Neoplasms/genetics ; Capecitabine/therapeutic use ; Carcinoma/drug therapy ; Carcinoma/genetics ; Female ; Furans/therapeutic use ; Gastrointestinal Diseases/chemically induced ; Genes, erbB-2 ; Germ-Line Mutation ; Hematologic Diseases/chemically induced ; Humans ; Kaplan-Meier Estimate ; Ketones/therapeutic use ; Middle Aged ; Phthalazines/adverse effects ; Piperazines/adverse effects ; Progression-Free Survival ; Single-Blind Method ; Vinorelbine/therapeutic use
Czasopismo naukowe
Tytuł :
Breast cancer prevention in high-risk women.
Autorzy :
Thorat MA; Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, United Kingdom; School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, United Kingdom; Breast Services, Guy's Hospital, Great Maze Pond, London, SE1 9RT, United Kingdom. Electronic address: .
Balasubramanian R; Breast Services, Guy's Hospital, Great Maze Pond, London, SE1 9RT, United Kingdom.
Pokaż więcej
Źródło :
Best practice & research. Clinical obstetrics & gynaecology [Best Pract Res Clin Obstet Gynaecol] 2020 May; Vol. 65, pp. 18-31. Date of Electronic Publication: 2019 Nov 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genes, BRCA1*
Genes, BRCA2*
Genetic Predisposition to Disease*
Breast Neoplasms/*prevention & control
Mutation/*genetics
Salpingo-oophorectomy/*methods
Breast Neoplasms/genetics ; Breast Neoplasms/mortality ; Breast Neoplasms/surgery ; Female ; Germ-Line Mutation ; Heterozygote ; Humans ; Mastectomy/methods
Czasopismo naukowe
Tytuł :
[Detecting Large Germline Rearrangements of BRCA1 by Next Generation Tumor Sequencing].
Autorzy :
Minucci A; Molecular Diagnostic and Genomics Laboratory, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 00168 Italy.; .
Mazzuccato G; Molecular Diagnostic and Genomics Laboratory, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 00168 Italy.
Marchetti C; Division of Oncological Gynecology, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 00168 Italy.; Catholic University of the Sacred Heart, Rome, 00168 Italy.
Pietragalla A; Division of Oncological Gynecology, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 00168 Italy.
Scambia G; Division of Oncological Gynecology, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 00168 Italy.; Catholic University of the Sacred Heart, Rome, 00168 Italy.
Fagotti A; Division of Oncological Gynecology, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 00168 Italy.; Catholic University of the Sacred Heart, Rome, 00168 Italy.
Urbani A; Molecular Diagnostic and Genomics Laboratory, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 00168 Italy.; Catholic University of the Sacred Heart, Rome, 00168 Italy.; .
Pokaż więcej
Źródło :
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2020 May-Jun; Vol. 54 (4), pp. 688-698.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genes, BRCA1*
High-Throughput Nucleotide Sequencing*
BRCA1 Protein/*genetics
Breast Neoplasms/*genetics
Ovarian Neoplasms/*genetics
DNA Copy Number Variations/genetics ; Female ; Germ Cells/metabolism ; Germ-Line Mutation ; Humans
Czasopismo naukowe
Tytuł :
Olaparib Versus Nonplatinum Chemotherapy in Patients With Platinum-Sensitive Relapsed Ovarian Cancer and a Germline BRCA1/2 Mutation (SOLO3): A Randomized Phase III Trial.
Autorzy :
Penson RT; Harvard Medical School and Massachusetts General Hospital, Boston, MA.
Valencia RV; Centro Medico Dalinde, Mexico City, Mexico.
Cibula D; First Faculty of Medicine, Charles University and General University, Prague, Czech Republic.
Colombo N; University of Milan-Bicocca and IEO European Institute of Oncology IRCCS, Milan, Italy.
Leath CA 3rd; University of Alabama, Birmingham, AL.
Bidziński M; Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, Poland.
Kim JW; Seoul National University Hospital, Seoul, South Korea.
Nam JH; Asan Medical Center, Seoul, South Korea.
Madry R; Medical University K. Marcinkowski and Clinical Hospital of the Transfiguration, Poznań, Poland.
Hernández C; Oaxaca Site Management Organization, Oaxaca de Juarez, Mexico.
Mora PAR; Instituto COI de Educação e Pesquisa, Rio de Janeiro, Brazil.
Ryu SY; Korea Institute of Radiological and Medical Sciences, Seoul, South Korea.
Milenkova T; AstraZeneca, Cambridge, United Kingdom.
Lowe ES; AstraZeneca, Gaithersburg, MD.
Barker L; AstraZeneca, Cambridge, United Kingdom.
Scambia G; Università Cattolica del Sacro Cuore-Fondazione Policlinico A. Gemelli, IRCCS, Rome, Italy.
Pokaż więcej
Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2020 Apr 10; Vol. 38 (11), pp. 1164-1174. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji :
Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, BRCA1*
Genes, BRCA2*
Germ-Line Mutation*
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Ovarian Neoplasms/*drug therapy
Phthalazines/*therapeutic use
Piperazines/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Middle Aged ; Neoplasm Recurrence, Local ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/mortality ; Phthalazines/adverse effects ; Piperazines/adverse effects ; Platinum Compounds/therapeutic use
Czasopismo naukowe
Tytuł :
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Autorzy :
Konstantinopoulos PA; Dana-Farber Cancer Institute, Boston, MA.
Norquist B; University of Washington Medicine, Seattle, WA.
Lacchetti C; American Society of Clinical Oncology, Alexandria, VA.
Armstrong D; Johns Hopkins, Baltimore, MD.
Grisham RN; Memorial Sloan Kettering Cancer Center, New York, NY.
Goodfellow PJ; Ohio State University Comprehensive Cancer Center, Columbus, OH.
Kohn EC; Gynecologic Cancer Therapeutics, National Cancer Institute, Bethesda, MD.
Levine DA; NYU Langone Health, New York, NY.
Liu JF; Dana-Farber Cancer Institute, Boston, MA.
Lu KH; The University of Texas MD Anderson Cancer Center, Houston,TX.
Sparacio D; Patient Representative, Hightstown, NJ.
Annunziata CM; Women's Malignancies Branch, National Cancer Institute, Bethesda, MD.
Pokaż więcej
Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2020 Apr 10; Vol. 38 (11), pp. 1222-1245. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Genes, BRCA1*
Genes, BRCA2*
Genetic Testing*
Germ-Line Mutation*
Carcinoma, Ovarian Epithelial/*genetics
Ovarian Neoplasms/*genetics
Carcinoma, Ovarian Epithelial/drug therapy ; Carcinoma, Ovarian Epithelial/mortality ; Female ; Genetic Counseling ; Health Status Disparities ; Humans ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/mortality ; Practice Guidelines as Topic ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
Mainstreamed genetic testing of breast cancer patients in two hospitals in South Eastern Norway.
Autorzy :
Grindedal EM; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway. .
Jørgensen K; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Olsson P; Department of Surgery, Section of Breast and Endocrine Surgery, Innlandet Hospital, Hamar, Norway.
Gravdehaug B; Department of Breast and Endocrine Surgery, Akershus University Hospital, Lørenskog, Norway.
Lurås H; Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Schlichting E; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Oncology, Section of Breast- and Endocrine Surgery, Oslo University Hospital, Oslo, Norway.
Vamre T; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Wangensteen T; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Heramb C; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Mæhle L; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Pokaż więcej
Źródło :
Familial cancer [Fam Cancer] 2020 Apr; Vol. 19 (2), pp. 133-142.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, BRCA1*
Breast Neoplasms/*genetics
Genetic Testing/*statistics & numerical data
Health Care Surveys/*statistics & numerical data
Neoplastic Syndromes, Hereditary/*genetics
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Breast Neoplasms, Male/genetics ; Female ; Hospitals/statistics & numerical data ; Humans ; Male ; Middle Aged ; Neoplastic Syndromes, Hereditary/diagnosis ; Norway
Czasopismo naukowe
Tytuł :
Molecular profiles of BRCA1-associated ovarian cancer treated by platinum-based therapy: Analysis of primary, residual and relapsed tumors.
Autorzy :
Sokolenko AP; Department of Tumour Growth Biology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia.; Department of Medical Genetics, St.-Petersburg Pediatric Medical University, St.-Petersburg, Russia.
Bizin IV; Department of Tumour Growth Biology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia.
Preobrazhenskaya EV; Department of Tumour Growth Biology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia.; Department of Medical Genetics, St.-Petersburg Pediatric Medical University, St.-Petersburg, Russia.
Gorodnova TV; Department of Tumour Growth Biology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia.
Ivantsov AO; Department of Tumour Growth Biology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia.
Iyevleva AG; Department of Tumour Growth Biology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia.; Department of Medical Genetics, St.-Petersburg Pediatric Medical University, St.-Petersburg, Russia.
Savonevich EL; Department of Obstetrics and Gynecology, Grodno State Medical University, Grodno, Belarus.
Kotiv KB; Department of Tumour Growth Biology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia.
Kuligina ES; Department of Tumour Growth Biology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia.
Imyanitov EN; Department of Tumour Growth Biology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia.; Department of Medical Genetics, St.-Petersburg Pediatric Medical University, St.-Petersburg, Russia.
Pokaż więcej
Źródło :
International journal of cancer [Int J Cancer] 2020 Apr 01; Vol. 146 (7), pp. 1879-1888. Date of Electronic Publication: 2019 Nov 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, BRCA1*
Transcriptome*
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Ovarian Neoplasms/*drug therapy
Ovarian Neoplasms/*genetics
Alleles ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Biomarkers, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Genotype ; Humans ; Models, Biological ; Mutation ; Ovarian Neoplasms/diagnosis ; Platinum/administration & dosage ; Recurrence ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Integrating DNA methylation measures to improve clinical risk assessment: are we there yet? The case of BRCA1 methylation marks to improve clinical risk assessment of breast cancer.
Autorzy :
Wong EM; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia.
Southey MC; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Terry MB; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. .; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA. .
Pokaż więcej
Źródło :
British journal of cancer [Br J Cancer] 2020 Apr; Vol. 122 (8), pp. 1133-1140. Date of Electronic Publication: 2020 Feb 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Methylation*
Genes, BRCA1*
Genetic Predisposition to Disease*
Risk Assessment*
Breast Neoplasms/*genetics
Breast Neoplasms/etiology ; Female ; Humans ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
Perceptions of risk and reward in BRCA1 and BRCA2 mutation carriers choosing salpingectomy for ovarian cancer prevention.
Autorzy :
Ghezelayagh TS; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific St, Box 356460, Seattle, WA, 98195-6460, USA. .
Stewart LE; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific St, Box 356460, Seattle, WA, 98195-6460, USA.; Department of Obstetrics and Gynecology, Women & Infants Hospital of Rhode Island, Providence, RI, USA.
Norquist BM; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific St, Box 356460, Seattle, WA, 98195-6460, USA.
Bowen DJ; Department of Bioethics and Humanities, Department of Health Services, University of Washington, Seattle, WA, USA.
Yu V; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific St, Box 356460, Seattle, WA, 98195-6460, USA.; Department of Obstetrics and Gynecology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA.
Agnew KJ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific St, Box 356460, Seattle, WA, 98195-6460, USA.
Pennington KP; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific St, Box 356460, Seattle, WA, 98195-6460, USA.
Swisher EM; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific St, Box 356460, Seattle, WA, 98195-6460, USA.
Pokaż więcej
Źródło :
Familial cancer [Fam Cancer] 2020 Apr; Vol. 19 (2), pp. 143-151. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, BRCA1*
Genes, BRCA2*
Heterozygote*
Ovarian Neoplasms/*prevention & control
Salpingectomy/*psychology
Adult ; Age Factors ; Decision Making ; Female ; Health Surveys ; Humans ; Middle Aged ; Motivation ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/surgery ; Patient Satisfaction/statistics & numerical data ; Reward ; Risk ; Salpingectomy/statistics & numerical data
Czasopismo naukowe
Tytuł :
Use of SNP chips to detect rare pathogenic variants: retrospective, population based diagnostic evaluation.
Autorzy :
Mn W; Institute of Biomedical and Clinical Science, University of Exeter College of Medicine and Health, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK.
L J; Institute of Biomedical and Clinical Science, University of Exeter College of Medicine and Health, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK.
Jw H; Institute of Biomedical and Clinical Science, University of Exeter College of Medicine and Health, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK.
Ks R; Institute of Biomedical and Clinical Science, University of Exeter College of Medicine and Health, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK.
J T; Institute of Biomedical and Clinical Science, University of Exeter College of Medicine and Health, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK.
At H; Institute of Biomedical and Clinical Science, University of Exeter College of Medicine and Health, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK.
Cf W; Institute of Biomedical and Clinical Science, University of Exeter College of Medicine and Health, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK.
Pokaż więcej
Źródło :
BMJ (Clinical research ed.) [BMJ] 2021 Feb 15; Vol. 372, pp. n214. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Throughput Nucleotide Sequencing*
Oligonucleotide Array Sequence Analysis*
Breast Neoplasms/*diagnosis
Ovarian Neoplasms/*diagnosis
Pancreatic Neoplasms/*diagnosis
Prostatic Neoplasms/*diagnosis
Adult ; Aged ; Breast Neoplasms/genetics ; False Negative Reactions ; False Positive Reactions ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Testing/methods ; Genotyping Techniques ; Humans ; Male ; Middle Aged ; Ovarian Neoplasms/genetics ; Pancreatic Neoplasms/genetics ; Polymorphism, Single Nucleotide ; Predictive Value of Tests ; Prostatic Neoplasms/genetics ; Registries ; Retrospective Studies ; Sequence Analysis, DNA
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies