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Wyszukujesz frazę ""Genes, Switch"" wg kryterium: Temat


Tytuł :
Robust and flexible platform for directed evolution of yeast genetic switches.
Autorzy :
Tominaga M; Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Japan.
Nozaki K; Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Japan.
Umeno D; Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Chiba University, Chiba, Japan.
Ishii J; Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Japan. .; Engineering Biology Research Center, Kobe University, Kobe, Japan. .
Kondo A; Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Japan.; Engineering Biology Research Center, Kobe University, Kobe, Japan.; Department of Chemical Science and Engineering, Faculty of Engineering, Kobe University, Kobe, Japan.; Center for Sustainable Resource Science, RIKEN, Yokohama, Japan.
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Źródło :
Nature communications [Nat Commun] 2021 Mar 23; Vol. 12 (1), pp. 1846. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Switch*
Genetic Techniques*
Directed Molecular Evolution/*methods
Genetic Engineering/*methods
Saccharomyces cerevisiae/*genetics
Synthetic Biology/*methods
Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Basidiomycota/genetics ; Basidiomycota/metabolism ; Flow Cytometry ; Gene Library ; Genes, Reporter ; Phloroglucinol/analogs & derivatives ; Phloroglucinol/pharmacology ; Promoter Regions, Genetic ; Repressor Proteins/chemistry ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Signal-To-Noise Ratio ; Tetracycline/pharmacology ; Trans-Activators/chemistry ; Trans-Activators/genetics ; Trans-Activators/metabolism ; beta Carotene/biosynthesis ; beta Carotene/genetics ; beta Carotene/metabolism
SCR Organism :
Phaffia rhodozyma
Czasopismo naukowe
Tytuł :
Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene.
Autorzy :
Potashkin JA; Center for Neurodegenerative Diseases and Therapeutics, Cellular and Molecular Pharmacology Department, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064 USA.
Bottero V; Center for Neurodegenerative Diseases and Therapeutics, Cellular and Molecular Pharmacology Department, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064 USA.
Santiago JA; NeuroHub Analytics, LLC, Chicago, IL 60605, USA.
Quinn JP; Q Regulating Systems, LLC, Gurnee, IL 60031, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 May 27; Vol. 21 (11). Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Computational Biology*
Genes, Switch*
Adaptor Proteins, Signal Transducing/*genetics
Cytoskeletal Proteins/*genetics
Dementia/*genetics
Frontal Lobe/*pathology
Alzheimer Disease/genetics ; Brain/metabolism ; Data Mining ; Databases, Genetic ; Dementia, Vascular/genetics ; Frontotemporal Dementia/genetics ; Gene Expression Regulation ; Humans ; Signal Transduction/genetics ; Software ; Transcription Factors/metabolism ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Theoretical investigation of a genetic switch for metabolic adaptation.
Autorzy :
Laxhuber KS; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.
Morrison MJ; Department of Physics, California Institute of Technology, Pasadena, CA, United States of America.
Chure G; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States of America.
Belliveau NM; Howard Hughes Medical Institute, University of Washington, Seattle, WA, United States of America.
Strandkvist C; Department of Systems Biology, Harvard Medical School, Boston, MA, United States of America.
Naughton KL; Department of Physics and Astronomy, University of Southern California, Los Angeles, CA, United States of America.
Phillips R; Department of Physics, California Institute of Technology, Pasadena, CA, United States of America.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States of America.
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Źródło :
PloS one [PLoS One] 2020 May 07; Vol. 15 (5), pp. e0226453. Date of Electronic Publication: 2020 May 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Regulatory Networks*
Genes, Switch*
Models, Biological*
Adaptation, Physiological/*genetics
Escherichia coli/*genetics
Escherichia coli/*metabolism
Binding Sites ; Biological Transport/genetics ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Feedback, Physiological ; Gene Expression Regulation, Bacterial ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Pentosyltransferases/genetics ; Pentosyltransferases/metabolism ; Promoter Regions, Genetic ; RNA, Messenger/metabolism ; Ribonucleosides/metabolism ; Stochastic Processes ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Exploring polyps to colon carcinoma voyage: can blocking the crossroad halt the sequence?
Autorzy :
Khan AA; Division of Microbiology, Indian Council of Medical Research-National AIDS Research Institute, Pune, Maharashtra, India. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Aug; Vol. 147 (8), pp. 2199-2207. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Transformation, Neoplastic*/drug effects
Cell Transformation, Neoplastic*/genetics
Cell Transformation, Neoplastic*/metabolism
Cell Transformation, Neoplastic*/pathology
Carcinoma/*prevention & control
Colonic Neoplasms/*prevention & control
Colonic Polyps/*therapy
Molecular Targeted Therapy/*methods
Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adenocarcinoma/prevention & control ; Adenoma/genetics ; Adenoma/metabolism ; Adenoma/pathology ; Adenoma/prevention & control ; Adenomatous Polyps/genetics ; Adenomatous Polyps/metabolism ; Adenomatous Polyps/pathology ; Adenomatous Polyps/prevention & control ; Antineoplastic Agents/therapeutic use ; Carcinoma/genetics ; Carcinoma/metabolism ; Carcinoma/pathology ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Colonic Polyps/genetics ; Colonic Polyps/metabolism ; Colonic Polyps/pathology ; Disease Progression ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Regulatory Networks/drug effects ; Gene Regulatory Networks/physiology ; Genes, Switch/drug effects ; Humans ; Protein Interaction Maps/drug effects ; Protein Interaction Maps/genetics ; Proteomics ; Signal Transduction/drug effects ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Key Disease Mechanisms Linked to Alzheimer's Disease in the Entorhinal Cortex.
Autorzy :
Bottero V; Center for Neurodegenerative Diseases and Therapeutics, Discipline of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Powers D; Center for Neurodegenerative Diseases and Therapeutics, Discipline of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Yalamanchi A; Center for Neurodegenerative Diseases and Therapeutics, Discipline of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Quinn JP; Q Regulating Systems, LLC, Gurnee, IL 60031, USA.
Potashkin JA; Center for Neurodegenerative Diseases and Therapeutics, Discipline of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 10; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 10.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*genetics
Amyloid beta-Peptides/*genetics
Genes, Switch/*genetics
Inflammation/*genetics
Aging/genetics ; Aging/pathology ; Alzheimer Disease/pathology ; Brain/metabolism ; Brain/pathology ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/pathology ; Early Growth Response Protein 1/genetics ; Entorhinal Cortex/pathology ; Gene Expression Regulation/genetics ; Humans ; Inflammation/pathology ; PPAR gamma/genetics ; Phospholipase D/genetics ; Plaque, Amyloid ; Signal Transduction/genetics ; Software ; Sterol Regulatory Element Binding Protein 2/genetics ; YY1 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Orthogonal Protein-Responsive mRNA Switches for Mammalian Synthetic Biology.
Autorzy :
Ono H; Department of Life Science Frontiers, Center for iPS Cell Research and Application , Kyoto University , 53 Kawahara-cho , Shogoin, Sakyo-ku, Kyoto 606-8507 , Japan.; Graduate School of Medicine , Kyoto University , Kyoto 606-8507 , Japan.
Kawasaki S; Department of Life Science Frontiers, Center for iPS Cell Research and Application , Kyoto University , 53 Kawahara-cho , Shogoin, Sakyo-ku, Kyoto 606-8507 , Japan.
Saito H; Department of Life Science Frontiers, Center for iPS Cell Research and Application , Kyoto University , 53 Kawahara-cho , Shogoin, Sakyo-ku, Kyoto 606-8507 , Japan.
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Źródło :
ACS synthetic biology [ACS Synth Biol] 2020 Jan 17; Vol. 9 (1), pp. 169-174. Date of Electronic Publication: 2019 Dec 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Switch*
Protein Biosynthesis/*genetics
Protein Engineering/*methods
RNA, Messenger/*genetics
RNA-Binding Proteins/*genetics
Aptamers, Nucleotide ; Gene Expression Regulation ; Gene Regulatory Networks ; HEK293 Cells ; Humans ; Nucleotide Motifs/genetics ; Plasmids/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Synthetic Biology/methods ; Transfection
Czasopismo naukowe
Tytuł :
Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases.
Autorzy :
Mundo L; Department of Medical Biotechnology, University of Siena, Siena, Italy.
Ambrosio MR; Department of Medical Biotechnology, University of Siena, Siena, Italy.
Raimondi F; Cell Networks, Bioquant, University of Heidelberg, Heidelberg, Germany.
Del Porro L; Department of Medical Biotechnology, University of Siena, Siena, Italy.
Guazzo R; Department of Medical Biotechnology, University of Siena, Siena, Italy.
Mancini V; Department of Medical Biotechnology, University of Siena, Siena, Italy.
Granai M; Department of Medical Biotechnology, University of Siena, Siena, Italy.
Jim Rocca B; Department of Medical Biotechnology, University of Siena, Siena, Italy.
Lopez C; Ulm University and Ulm University Medical Center, Ulm, Germany.
Bens S; Ulm University and Ulm University Medical Center, Ulm, Germany.
Onyango N; University of Nairobi, Nairobi, Kenya.
Nyagol J; University of Nairobi, Nairobi, Kenya.
Abinya N; University of Nairobi, Nairobi, Kenya.
Navari M; Department of Medical Biotechnology & Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Ndede I; Moi Eldoret University, Eldoret, Kenya.
Patel K; Moi Eldoret University, Eldoret, Kenya.
Paolo Piccaluga P; Department of Experimental, Diagnostic, and Specialty Medicine Bologna University Medical School, S. Orsola Malpighi Hospital, Bologna and Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy.; Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
Bob R; Pathodiagnostik Lab, Berlin, Germany.
de Santi MM; Department of Medical Biotechnology, University of Siena, Siena, Italy.
Russell RB; Cell Networks, Bioquant, University of Heidelberg, Heidelberg, Germany.
Lazzi S; Department of Medical Biotechnology, University of Siena, Siena, Italy.
Siebert R; Ulm University and Ulm University Medical Center, Ulm, Germany.
Stein H; Pathodiagnostik Lab, Berlin, Germany.
Leoncini L; Department of Medical Biotechnology, University of Siena, Siena, Italy. .
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Źródło :
Blood cancer journal [Blood Cancer J] 2019 Nov 20; Vol. 9 (12), pp. 91. Date of Electronic Publication: 2019 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Genes, Switch*
Genes, myc*
Burkitt Lymphoma/*genetics
Burkitt Lymphoma/*metabolism
Adolescent ; Adult ; Aged ; Burkitt Lymphoma/epidemiology ; Burkitt Lymphoma/pathology ; Child ; Female ; Genomics/methods ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; Immunophenotyping ; Male ; Middle Aged ; Models, Molecular ; Mutation ; Protein Conformation ; RNA, Messenger/genetics ; Structure-Activity Relationship ; Translocation, Genetic ; Young Adult
Czasopismo naukowe
Tytuł :
The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges.
Autorzy :
Loh CY; School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya 47500, Malaysia. .
Chai JY; School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya 47500, Malaysia. .
Tang TF; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. .
Wong WF; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. .
Sethi G; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. .
Shanmugam MK; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. .
Chong PP; School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya 47500, Malaysia. .
Looi CY; School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya 47500, Malaysia. .
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Źródło :
Cells [Cells] 2019 Sep 20; Vol. 8 (10). Date of Electronic Publication: 2019 Sep 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genes, Switch*/genetics
Cadherins/*genetics
Carcinogenesis/*genetics
Epithelial-Mesenchymal Transition/*genetics
Animals ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/therapeutic use ; Drug Discovery/methods ; Drug Discovery/trends ; Gene Expression Regulation, Neoplastic ; Humans ; Molecular Targeted Therapy/methods ; Molecular Targeted Therapy/standards ; Molecular Targeted Therapy/trends ; Multigene Family/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Single-cell lineage analysis reveals extensive multimodal transcriptional control during directed beta-cell differentiation.
Autorzy :
Weng C; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; The Biomedical Sciences Training Program (BSTP), School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Xi J; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Li H; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Cui J; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Gu A; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Medical Scientist Training Program (MSTP), School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Lai S; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; The Biomedical Sciences Training Program (BSTP), School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Leskov K; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Ke L; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Master of Science in Biology Program, Department of Biology, College of Arts and Sciences, Case Western Reserve University, Cleveland, OH, USA.
Jin F; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. .; Department of Population and Quantitative Health Sciences, Department of Electrical Engineering and Computer Science, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. .
Li Y; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. .
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Źródło :
Nature metabolism [Nat Metab] 2020 Dec; Vol. 2 (12), pp. 1443-1458. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation/*physiology
Cell Lineage/*physiology
Gene Expression Regulation, Developmental/*physiology
Insulin-Secreting Cells/*physiology
Cell Differentiation/genetics ; Cell Lineage/genetics ; Diabetes Mellitus/genetics ; Embryonic Stem Cells ; Gene Expression Regulation, Developmental/genetics ; Gene Knockdown Techniques ; Genes, Switch/genetics ; Glucose/pharmacology ; Humans ; Insulin Secretion/drug effects ; Transcription Factor 7-Like 2 Protein/genetics ; Transcription Factor HES-1/biosynthesis ; Transcription Factor HES-1/genetics
Czasopismo naukowe
Tytuł :
Transcriptomics of the grape berry shrivel ripening disorder.
Autorzy :
Savoi S; Division of Viticulture and Pomology, Department of Crop Sciences, University of Natural Resources and Life Sciences, Vienna, Konrad Lorenz Straße 24, 3430, Tulln, Austria.
Herrera JC; Division of Viticulture and Pomology, Department of Crop Sciences, University of Natural Resources and Life Sciences, Vienna, Konrad Lorenz Straße 24, 3430, Tulln, Austria.
Forneck A; Division of Viticulture and Pomology, Department of Crop Sciences, University of Natural Resources and Life Sciences, Vienna, Konrad Lorenz Straße 24, 3430, Tulln, Austria.
Griesser M; Division of Viticulture and Pomology, Department of Crop Sciences, University of Natural Resources and Life Sciences, Vienna, Konrad Lorenz Straße 24, 3430, Tulln, Austria. .
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Źródło :
Plant molecular biology [Plant Mol Biol] 2019 Jun; Vol. 100 (3), pp. 285-301. Date of Electronic Publication: 2019 Apr 02.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Developmental*
Genes, Switch*
Transcriptome*
Fruit/*genetics
Fruit/*metabolism
Plant Growth Regulators/*genetics
Vitis/*genetics
Vitis/*metabolism
Anthocyanins/metabolism ; Carbohydrate Metabolism ; Flavonoids/metabolism ; Fruit/growth & development ; Gene Expression Profiling/methods ; Gene Expression Regulation, Plant/genetics ; Gene Expression Regulation, Plant/physiology ; Genes, Plant/genetics ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Sequence Analysis, RNA ; Sugars/metabolism ; Transcription, Genetic ; Vitis/growth & development
Czasopismo naukowe
Tytuł :
Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration.
Autorzy :
Eggers R; Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands.
de Winter F; Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands.
Hoyng SA; Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands.
Hoeben RC; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
Malessy MJA; Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands.; Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands.
Tannemaat MR; Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands.; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Verhaagen J; Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands.; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognition research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
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Źródło :
Brain : a journal of neurology [Brain] 2019 Feb 01; Vol. 142 (2), pp. 295-311.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Axons/*physiology
Genes, Switch/*physiology
Genetic Therapy/*methods
Glial Cell Line-Derived Neurotrophic Factor/*genetics
Immune Evasion/*physiology
Nerve Regeneration/*physiology
Animals ; Axons/drug effects ; Cell Survival/drug effects ; Cell Survival/physiology ; Cells, Cultured ; Female ; Genes, Switch/drug effects ; Glial Cell Line-Derived Neurotrophic Factor/administration & dosage ; Immune Evasion/drug effects ; Nerve Regeneration/drug effects ; Rats ; Rats, Wistar ; Schwann Cells/drug effects ; Schwann Cells/physiology ; Time Factors
Czasopismo naukowe
Tytuł :
Cell membrane dynamics induction using optogenetic tools.
Autorzy :
Ueda Y; Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan; AMED-PRIME, Japan Agency for Medical Research and Development, Tokyo, Japan.
Sato M; Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2018 Nov 25; Vol. 506 (2), pp. 387-393. Date of Electronic Publication: 2017 Nov 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genes, Switch*
Arabidopsis Proteins/*metabolism
Cell Membrane/*metabolism
DNA-Binding Proteins/*metabolism
Optogenetics/*methods
Pseudopodia/*metabolism
T-Lymphoma Invasion and Metastasis-inducing Protein 1/*metabolism
Animals ; Arabidopsis Proteins/genetics ; Cell Membrane/radiation effects ; Cell Membrane/ultrastructure ; Cell Movement ; Cyanobacteria/genetics ; Cyanobacteria/metabolism ; Cyanobacteria/radiation effects ; DNA-Binding Proteins/genetics ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Fibroblasts/radiation effects ; Fungi/genetics ; Fungi/metabolism ; Fungi/radiation effects ; Gene Expression Regulation ; Light Signal Transduction ; Magnets ; Mice ; Optogenetics/instrumentation ; Phosphatidylinositol Phosphates/metabolism ; Plants/genetics ; Plants/metabolism ; Plants/radiation effects ; Pseudopodia/radiation effects ; Pseudopodia/ultrastructure ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/genetics
Czasopismo naukowe
Tytuł :
Stochastic phenotype switching leads to intratumor heterogeneity in human liver cancer.
Autorzy :
Matak A; Institute of Pathology, Medical University of Graz, Graz, Austria.
Lahiri P; Institute of Pathology, Medical University of Graz, Graz, Austria.
Ford E; University of Western Australia, Crawley, WA, Australia.
Pabst D; Institute of Pathology, Medical University of Graz, Graz, Austria.
Kashofer K; Institute of Pathology, Medical University of Graz, Graz, Austria.
Stellas D; Biomedical Research Foundation, Academy of Athens, Athens, Greece.
Thanos D; Biomedical Research Foundation, Academy of Athens, Athens, Greece.
Zatloukal K; Institute of Pathology, Medical University of Graz, Graz, Austria.
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Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2018 Sep; Vol. 68 (3), pp. 933-948. Date of Electronic Publication: 2018 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Switch*
Genetic Heterogeneity*
Cholangiocarcinoma/*genetics
Liver Neoplasms/*genetics
Humans ; Phenotype ; Stochastic Processes ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43.
Autorzy :
Wang YJ; Department of Physics and Randall Centre for Cell and Molecular Biophysics , King's College London , WC2R 2LS , London , United Kingdom.
Rico-Lastres P; Department of Physics and Randall Centre for Cell and Molecular Biophysics , King's College London , WC2R 2LS , London , United Kingdom.
Lezamiz A; Department of Physics and Randall Centre for Cell and Molecular Biophysics , King's College London , WC2R 2LS , London , United Kingdom.
Mora M; Department of Physics and Randall Centre for Cell and Molecular Biophysics , King's College London , WC2R 2LS , London , United Kingdom.
Solsona C; Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences , University of Barcelona and Bellvitge Biomedical Research Institute (IDIBELL) L'Hospitalet de Llobregat , Barcelona 08907 , Spain.
Stirnemann G; CNRS Laboratoire de Biochimie Théorique, Institut de Biologie Physico-Chimique , Université Paris Denis Diderot, Sorbonne Paris Cité, PSL Research University , 75005 Paris , France.
Garcia-Manyes S; Department of Physics and Randall Centre for Cell and Molecular Biophysics , King's College London , WC2R 2LS , London , United Kingdom.
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Źródło :
The journal of physical chemistry letters [J Phys Chem Lett] 2018 Jul 19; Vol. 9 (14), pp. 3800-3807. Date of Electronic Publication: 2018 Jun 28.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Switch*
DNA-Binding Proteins/*chemistry
Tumor Suppressor Proteins/*chemistry
DNA-Binding Proteins/metabolism ; Humans ; Mechanical Phenomena ; Protein Domains ; Ribonucleoside Diphosphate Reductase
Czasopismo naukowe
Tytuł :
Cell fate potentials and switching kinetics uncovered in a classic bistable genetic switch.
Autorzy :
Fang X; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun, 130022, China.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.; College of Physics, Jilin University, Changchun, 130012, China.; Department of Chemistry and Physics, Stony Brook University, Stony Brook, NY, 11790, USA.
Liu Q; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun, 130022, China.
Bohrer C; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Hensel Z; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157, Oeiras, Portugal.
Han W; College of Physics, Jilin University, Changchun, 130012, China.
Wang J; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun, 130022, China. .; College of Physics, Jilin University, Changchun, 130012, China. .; Department of Chemistry and Physics, Stony Brook University, Stony Brook, NY, 11790, USA. .
Xiao J; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA. .
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Źródło :
Nature communications [Nat Commun] 2018 Jul 17; Vol. 9 (1), pp. 2787. Date of Electronic Publication: 2018 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Regulatory Networks*
Genes, Switch*
Bacteriophage lambda/*genetics
Escherichia coli K12/*genetics
Repressor Proteins/*genetics
Viral Regulatory and Accessory Proteins/*genetics
Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bacteriophage lambda/metabolism ; Escherichia coli K12/metabolism ; Escherichia coli K12/virology ; Genes, Reporter ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Repressor Proteins/metabolism ; Viral Regulatory and Accessory Proteins/metabolism
Czasopismo naukowe
Tytuł :
The thermo-regulated genetic switch of deep-sea filamentous phage SW1 and its distribution in the Pacific Ocean.
Autorzy :
Meng C; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
Li S; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
Fan Q; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
Chen R; School of Oceanography, State Key Laboratory of Ocean Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
Hu Y; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
Xiao X; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China.; School of Oceanography, State Key Laboratory of Ocean Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, PR China.
Jian H; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
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Źródło :
FEMS microbiology letters [FEMS Microbiol Lett] 2020 Jun 01; Vol. 367 (12).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Viral*/genetics
Shewanella*/virology
Temperature*
Bacteriophages/*genetics
Genes, Switch ; Pacific Ocean ; Seawater
SCR Organism :
Shewanella piezotolerans
Czasopismo naukowe
Tytuł :
Integrative Circuit-Host Modeling of a Genetic Switch in Varying Environments.
Autorzy :
Sickle JJ; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Ni C; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Shen D; Dougherty Valley High School, San Ramon, CA, 94582, USA.
Wang Z; Monte Vista High School, Danville, CA, 94506, USA.
Jin M; University Laboratory High School, Urbana, IL, 61801, USA.
Lu T; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .; Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .; Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 May 20; Vol. 10 (1), pp. 8383. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Synthetic Biology/*methods
Gene Regulatory Networks/physiology ; Genes, Switch/genetics ; Models, Genetic
Czasopismo naukowe
Tytuł :
Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains.
Autorzy :
Miller IC; The Wallace H. Coulter Department of Biomedical Engineering , Georgia Institute of Technology and Emory University , Atlanta , Georgia 30332 , United States.
Gamboa Castro M; The Wallace H. Coulter Department of Biomedical Engineering , Georgia Institute of Technology and Emory University , Atlanta , Georgia 30332 , United States.
Maenza J; The Wallace H. Coulter Department of Biomedical Engineering , Georgia Institute of Technology and Emory University , Atlanta , Georgia 30332 , United States.
Weis JP; The Wallace H. Coulter Department of Biomedical Engineering , Georgia Institute of Technology and Emory University , Atlanta , Georgia 30332 , United States.
Kwong GA; The Wallace H. Coulter Department of Biomedical Engineering , Georgia Institute of Technology and Emory University , Atlanta , Georgia 30332 , United States.; Institute for Electronics and Nanotechnology , Georgia Institute of Technology , Atlanta , Georgia 30332 , United States.; Parker H. Petit Institute of Bioengineering and Bioscience , Georgia Institute of Technology , Atlanta , Georgia 30332 , United States.; Integrated Cancer Research Center , Georgia Institute of Technology , Atlanta , Georgia 30332 , United States.; Georgia Immunoengineering Consortium , Emory University and Georgia Institute of Technology , Atlanta , Georgia 30332 , United States.
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Źródło :
ACS synthetic biology [ACS Synth Biol] 2018 Apr 20; Vol. 7 (4), pp. 1167-1173. Date of Electronic Publication: 2018 Apr 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genes, Switch*
Genetic Engineering/*methods
HSP70 Heat-Shock Proteins/*genetics
Low-Level Light Therapy/*methods
Animals ; Area Under Curve ; Body Temperature ; Gene Expression Regulation ; Hot Temperature ; Humans ; Jurkat Cells ; Lasers ; Low-Level Light Therapy/instrumentation ; Mice, Nude ; Nanotubes ; Promoter Regions, Genetic ; Surface Plasmon Resonance
Czasopismo naukowe
Tytuł :
Epigenetic Switching and Neonatal Nutritional Environment.
Autorzy :
Hashimoto K; Department of Preemptive Medicine and Metabolism, Tokyo Medical and Dental University, Tokyo, Japan. .
Ogawa Y; Department of Molecular and Cellular Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; AMED, CREST, Tokyo, Japan.
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2018; Vol. 1012, pp. 19-25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene-Environment Interaction*
Genes, Switch*
Infant Nutritional Physiological Phenomena*
Epigenesis, Genetic/*physiology
Animals ; Animals, Newborn ; DNA Methylation/physiology ; Humans ; Infant, Newborn ; Liver/growth & development ; Liver/metabolism
Czasopismo naukowe

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