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Wyszukujesz frazę ""Genes, T-Cell Receptor alpha"" wg kryterium: Temat


Tytuł :
Identification of Disease-associated Traits and Clonotypes in the T Cell Receptor Repertoire of Monozygotic Twins Affected by Inflammatory Bowel Diseases.
Autorzy :
Rosati E; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Pogorelyy MV; Laboratory of comparative and functional genomic, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation.; Department of Translational Medicine, Pirogov Russian National Research Medical University [RNRMU], Moscow, Russian Federation.
Dowds CM; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Moller FT; Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Sorensen SB; Focused Research Unit for Molecular Diagnostic and Clinical Research, University Hospital of Southern Denmark, Aabenraa, Denmark.; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Lebedev YB; Laboratory of comparative and functional genomic, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation.
Frey N; Department of Internal Medicine III, University Hospital Schleswig-Holstein, Kiel, Germany.
Schreiber S; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.
Spehlmann ME; Department of Internal Medicine III, University Hospital Schleswig-Holstein, Kiel, Germany.
Andersen V; Focused Research Unit for Molecular Diagnostic and Clinical Research, University Hospital of Southern Denmark, Aabenraa, Denmark.; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; IRS-Center Sønderjylland, University of Southern Denmark, Odense, Denmark.
Mamedov IZ; Laboratory of comparative and functional genomic, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation.; Department of Translational Medicine, Pirogov Russian National Research Medical University [RNRMU], Moscow, Russian Federation.; Laboratory of molecular biology, Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation.; CEITEC, Masaryk University, Brno, Czech Republic.
Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
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Źródło :
Journal of Crohn's & colitis [J Crohns Colitis] 2020 Jul 09; Vol. 14 (6), pp. 778-790.
Typ publikacji :
Journal Article; Twin Study
MeSH Terms :
Colitis, Ulcerative*/diagnosis
Colitis, Ulcerative*/immunology
Colitis, Ulcerative*/physiopathology
Crohn Disease*/diagnosis
Crohn Disease*/immunology
Crohn Disease*/physiopathology
Genes, T-Cell Receptor alpha*
Genes, T-Cell Receptor beta*
Receptors, Antigen, T-Cell, alpha-beta/*blood
Adult ; C-Reactive Protein/analysis ; Denmark ; Feces ; Female ; Germany ; Humans ; Leukocyte L1 Antigen Complex/analysis ; Male ; Patient Acuity ; Sequence Analysis, DNA ; Smoking/immunology ; Twins, Monozygotic
Czasopismo naukowe
Tytuł :
TCRα reporter mice reveal contribution of dual TCRα expression to T cell repertoire and function.
Autorzy :
Yang L; Department of Pathology, University of California San Diego, La Jolla, CA 92093.
Jama B; Department of Pathology, University of California San Diego, La Jolla, CA 92093.
Wang H; Department of Pathology, University of California San Diego, La Jolla, CA 92093.
Labarta-Bajo L; Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
Zúñiga EI; Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
Morris GP; Department of Pathology, University of California San Diego, La Jolla, CA 92093; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 22; Vol. 117 (51), pp. 32574-32583. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, T-Cell Receptor alpha/*physiology
Lymphocytic Choriomeningitis/*immunology
T-Lymphocytes/*physiology
Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/physiology ; CD4-Positive T-Lymphocytes/virology ; CD5 Antigens/immunology ; CD5 Antigens/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/virology ; Chlorocebus aethiops ; Female ; Gene Expression ; Green Fluorescent Proteins/genetics ; Immunologic Memory/genetics ; Lymphocytic choriomeningitis virus/pathogenicity ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Thymocytes/immunology ; Thymocytes/physiology ; Vero Cells
Czasopismo naukowe
Tytuł :
Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice.
Autorzy :
Xie J; Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710.; School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Pan Y; School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Tao H; Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710.
Wang P; Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710.
Chen Y; Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Gao J; School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; .
Zhong XP; Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710; .; Department of Immunology, Duke University Medical Center, Durham, NC 27710; and.; Hematologic Malignancies and Cellular Therapies Program, Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710.
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Źródło :
ImmunoHorizons [Immunohorizons] 2019 Jun 11; Vol. 3 (6), pp. 203-207. Date of Electronic Publication: 2019 Jun 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genes, T-Cell Receptor alpha*
Mucosal-Associated Invariant T Cells/*immunology
Mucous Membrane/*immunology
Natural Killer T-Cells/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*physiology
Adoptive Transfer ; Animals ; Cells, Cultured ; Cytokines/metabolism ; Germ-Line Mutation ; Humans ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell, alpha-beta/genetics
Czasopismo naukowe
Tytuł :
Comparison of Systemic EBV-positive T-Cell and NK-Cell Lymphoproliferative Diseases of Childhood Based on Classification Evolution: New Classification, Old Problems.
Autorzy :
Chen Z; Departments of Pathology.
Wang M; Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Guan P; Departments of Pathology.
Zhao S; Departments of Pathology.
Zhang W; Departments of Pathology.
Gao L; Departments of Pathology.
Tang Y; Departments of Pathology.
Li L; Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Liu W; Departments of Pathology.
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Źródło :
The American journal of surgical pathology [Am J Surg Pathol] 2020 Aug; Vol. 44 (8), pp. 1061-1072.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epstein-Barr Virus Infections/*classification
Herpesvirus 4, Human/*genetics
Killer Cells, Natural/*immunology
Lymphoproliferative Disorders/*classification
T-Lymphocytes/*immunology
Adolescent ; Adult ; Age of Onset ; Cell Proliferation ; Child ; Child, Preschool ; China ; Databases, Factual ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/pathology ; Epstein-Barr Virus Infections/virology ; Female ; Genes, T-Cell Receptor alpha ; Genes, T-Cell Receptor beta ; Humans ; Infant ; Killer Cells, Natural/pathology ; Lymphoproliferative Disorders/immunology ; Lymphoproliferative Disorders/pathology ; Lymphoproliferative Disorders/virology ; Male ; Middle Aged ; Prognosis ; RNA, Viral/genetics ; Retrospective Studies ; Risk Assessment ; Risk Factors ; T-Lymphocytes/pathology ; Time Factors ; Young Adult
Czasopismo naukowe
Tytuł :
T Cell Receptor Alpha Chain Genes in the Teleost Ballan Wrasse (Labrus bergylta) Are Subjected to Somatic Hypermutation.
Autorzy :
Bilal S; Department of Biological Sciences, University of Bergen, Bergen, Norway.
Lie KK; Institute of Marine Research (IMR), Bergen, Norway.
Sæle Ø; Institute of Marine Research (IMR), Bergen, Norway.
Hordvik I; Department of Biological Sciences, University of Bergen, Bergen, Norway.
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Źródło :
Frontiers in immunology [Front Immunol] 2018 May 22; Vol. 9, pp. 1101. Date of Electronic Publication: 2018 May 22 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, T-Cell Receptor alpha*
Somatic Hypermutation, Immunoglobulin*
Fishes/*genetics
Amino Acid Sequence ; Animals ; Chromosome Mapping ; Computational Biology/methods ; DNA, Complementary ; Genome ; Genomics/methods ; High-Throughput Nucleotide Sequencing ; Mutation ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
The deterministic role of 5-mers in microRNA-gene targeting.
Autorzy :
Hart M; a Institute of Human Genetics, Saarland University , Homburg , Germany.
Kern F; b Chair for Clinical Bioinformatics, Saarland University , Saarbrücken , Germany.
Backes C; b Chair for Clinical Bioinformatics, Saarland University , Saarbrücken , Germany.
Rheinheimer S; a Institute of Human Genetics, Saarland University , Homburg , Germany.
Fehlmann T; b Chair for Clinical Bioinformatics, Saarland University , Saarbrücken , Germany.
Keller A; b Chair for Clinical Bioinformatics, Saarland University , Saarbrücken , Germany.
Meese E; a Institute of Human Genetics, Saarland University , Homburg , Germany.
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Źródło :
RNA biology [RNA Biol] 2018; Vol. 15 (6), pp. 819-825. Date of Electronic Publication: 2018 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
3' Untranslated Regions*
Genes, T-Cell Receptor alpha*
MicroRNAs*/genetics
MicroRNAs*/metabolism
Computer Simulation ; HEK293 Cells ; Humans
Czasopismo naukowe
Tytuł :
Relationship between T-cell receptor α gene polymorphisms and symptomatic differences in patients with narcolepsy type 1.
Autorzy :
Ouyang H; Department of Clinical Neurology, Peking University People's Hospital, Beijing 100044, China.
Han F; Department of Clinical Pulmonology, Peking University People's Hospital, Beijing 100044, China.
Zhou ZC; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
Zheng QW; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
Wang YY; Department of Clinical Neurology, Peking University People's Hospital, Beijing 100044, China.
Zhang J; Department of Clinical Neurology, Peking University People's Hospital, Beijing 100044, China.
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Źródło :
Chinese medical journal [Chin Med J (Engl)] 2019 Aug 05; Vol. 132 (15), pp. 1796-1801.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, T-Cell Receptor alpha/*genetics
Narcolepsy/*genetics
Adolescent ; Child ; Female ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Genotype ; Haplotypes ; Humans ; Male ; Odds Ratio ; Polymorphism, Single Nucleotide/genetics
SCR Disease Name :
Narcolepsy 1
Czasopismo naukowe
Tytuł :
High-throughput single-cell sequencing of paired TCRα and TCRβ genes for the direct expression-cloning and functional analysis of murine T-cell receptors.
Autorzy :
Ludwig J; Department of B Cell Immunology, German Cancer Research Center, Heidelberg, Germany.
Huber AK; Department of B Cell Immunology, German Cancer Research Center, Heidelberg, Germany.
Bartsch I; Department of B Cell Immunology, German Cancer Research Center, Heidelberg, Germany.
Busse CE; Department of B Cell Immunology, German Cancer Research Center, Heidelberg, Germany.
Wardemann H; Department of B Cell Immunology, German Cancer Research Center, Heidelberg, Germany.
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Źródło :
European journal of immunology [Eur J Immunol] 2019 Aug; Vol. 49 (8), pp. 1269-1277. Date of Electronic Publication: 2019 May 02.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, T-Cell Receptor alpha/*genetics
Genes, T-Cell Receptor beta/*genetics
High-Throughput Nucleotide Sequencing/*methods
Receptors, Antigen, T-Cell, alpha-beta/*genetics
T-Lymphocytes/*physiology
Animals ; Clone Cells ; Mice ; Phenotype ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress.
Autorzy :
Malcolm TI; Department of Pathology, University of Cambridge, Cambridge CB21QP, UK.
Villarese P; Hematology and INSERM1151, Institut Necker-Enfants Malades, Université Sorbonne Paris Cité at Descartes and Assistance Publique-Hôpitaux de Paris, Paris 75743, France.
Fairbairn CJ; Department of Pathology, University of Cambridge, Cambridge CB21QP, UK.
Lamant L; Institut Universitaire de Cancérologie Oncopole, 1 Avenue Irène Joliot-Curie, Toulouse 31059, France.
Trinquand A; Hematology and INSERM1151, Institut Necker-Enfants Malades, Université Sorbonne Paris Cité at Descartes and Assistance Publique-Hôpitaux de Paris, Paris 75743, France.
Hook CE; Department of Histopathology and Cytology, Addenbrooke's Hospital, Cambridge CB20QQ, UK.
Burke GA; Department of Paediatric Oncology, Addenbrooke's Hospital, Cambridge CB20QQ, UK.
Brugières L; Département de Cancérologie de l'Enfant et l'Adolescent, Gustave Roussy, 114 rue Edouard Vaillant, Villejuif 94805, France.
Hughes K; Department of Veterinary Medicine, University of Cambridge, Cambridge CB3OES, UK.
Payet D; Centre d'Immunologie de Marseille Luminy (CIML), INSERM UMR1104, CNRS UMR7280, Aix-Marseille Université UM2, Marseille 13288, France.
Merkel O; Clinical Institute of Pathology, Medical University of Vienna, Vienna A-1090, Austria.
Schiefer AI; Clinical Institute of Pathology, Medical University of Vienna, Vienna A-1090, Austria.
Ashankyty I; Molecular Diagnostics and Personalized Therapeutics Unit, College of Applied Medical Sciences University of Ha'il, Ha'il, Kingdom of Saudi Arabia.
Mian S; Molecular Diagnostics and Personalized Therapeutics Unit, College of Applied Medical Sciences University of Ha'il, Ha'il, Kingdom of Saudi Arabia.
Wasik M; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6100, USA.
Turner M; The Babraham Institute, Cambridge CB223AT, UK.
Kenner L; Clinical Institute of Pathology, Medical University of Vienna, Vienna A-1090, Austria.; Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Wahringerstrasse 13A, A-1090 Vienna, Austria.; Department of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Asnafi V; Hematology and INSERM1151, Institut Necker-Enfants Malades, Université Sorbonne Paris Cité at Descartes and Assistance Publique-Hôpitaux de Paris, Paris 75743, France.
Macintyre E; Hematology and INSERM1151, Institut Necker-Enfants Malades, Université Sorbonne Paris Cité at Descartes and Assistance Publique-Hôpitaux de Paris, Paris 75743, France.
Turner SD; Department of Pathology, University of Cambridge, Cambridge CB21QP, UK.
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Źródło :
Nature communications [Nat Commun] 2016 Jan 12; Vol. 7, pp. 10087. Date of Electronic Publication: 2016 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, T-Cell Receptor alpha*
Genes, T-Cell Receptor beta*
Lymphoma, Large-Cell, Anaplastic/*metabolism
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
Thymocytes/*metabolism
Thymus Gland/*cytology
Adult ; Animals ; CD4 Antigens/metabolism ; Cell Line, Tumor ; Child ; Disease Models, Animal ; Female ; Flow Cytometry ; Gene Rearrangement, T-Lymphocyte ; Genes, RAG-1/genetics ; Humans ; Immunohistochemistry ; Jurkat Cells ; Male ; Mice ; Mice, Transgenic ; Protein-Tyrosine Kinases/metabolism ; Receptor, Notch1/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Evaluation of bovine thymic function by measurement of signal joint T-cell receptor excision circles.
Autorzy :
Hisazumi R; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki 889-2192, Japan; Forensic Science Laboratory, Miyazaki Prefecture Police H.Q., Miyazaki 880-8509, Japan.
Kayumi M; Department of Veterinary Anatomy, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
Zhang W; Department of Veterinary Anatomy, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
Kikukawa R; NOSAI Miyakonojyo, Miyazaki 885-0012, Japan.
Nasu T; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki 889-2192, Japan; Department of Veterinary Anatomy, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
Yasuda M; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki 889-2192, Japan; Department of Veterinary Anatomy, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan. Electronic address: .
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Źródło :
Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 2016 Jan; Vol. 169, pp. 74-8. Date of Electronic Publication: 2015 Dec 29.
Typ publikacji :
Journal Article
MeSH Terms :
DNA, Circular*
Genes, T-Cell Receptor alpha*
Thymus Gland/*physiology
Animals ; CD4 Lymphocyte Count ; CD8-Positive T-Lymphocytes ; Cattle ; Female ; Male ; Real-Time Polymerase Chain Reaction/veterinary ; Seasons ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection.
Autorzy :
Albers JJ; Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Ammon T; Experimental Hematology Group, Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Gosmann D; Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Audehm S; Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Thoene S; Institut für Klinische Chemie und Pathobiochemie, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.; German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Winter C; Institut für Klinische Chemie und Pathobiochemie, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.; German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Secci R; Institut für Klinische Chemie und Pathobiochemie, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Wolf A; Klinik und Poliklinik für Innere Medizin I, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Stelzl A; Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Steiger K; Institut für Allgemeine Pathologie und Pathologische Anatomie, Technische Universität München, Munich, Germany.; German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ruland J; Institut für Klinische Chemie und Pathobiochemie, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.; German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.
Bassermann F; Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.; German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kupatt C; Klinik und Poliklinik für Innere Medizin I, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Partner-Site Munich Heart Alliance, Munich, Germany.
Anton M; Institut für Molekulare Immunologie und Experimentelle Onkologie und Therapieforschung, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Krackhardt AM; Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany .; German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany.
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Źródło :
Life science alliance [Life Sci Alliance] 2019 Mar 15; Vol. 2 (2). Date of Electronic Publication: 2019 Mar 15 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Engineering/*methods
Gene Editing/*methods
Neoplasms/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
T-Lymphocytes/*immunology
Animals ; CRISPR-Associated Protein 9/genetics ; Cell Line ; Genes, T-Cell Receptor alpha/genetics ; Genetic Vectors ; Humans ; Immunotherapy, Adoptive/methods ; Mice ; Mice, Inbred NOD ; Mice, Transgenic ; Neoplasms/therapy ; Tissue Donors ; Transduction, Genetic ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Monomorphic epitheliotropic intestinal T-cell lymphoma with T-cell receptor (TCR) of silent phenotype shows rearrangement of TCRβ or TCRγ gene.
Autorzy :
Tomita S; Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
Kikuti YY; Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
Carreras J; Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
Nakamura N; Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
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Źródło :
Pathology international [Pathol Int] 2019 Feb; Vol. 69 (2), pp. 117-118. Date of Electronic Publication: 2018 Dec 21.
Typ publikacji :
Letter
MeSH Terms :
Enteropathy-Associated T-Cell Lymphoma/*genetics
Genes, T-Cell Receptor alpha/*genetics
Genes, T-Cell Receptor beta/*genetics
Adult ; Aged ; Gene Rearrangement ; Humans ; Male ; Middle Aged ; Phenotype
Opinia redakcyjna
Tytuł :
Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.
Autorzy :
Naik AK; Department of Immunology, Duke University Medical Center, Durham, NC 27710; and.
Hawwari A; Department of Genetics, King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia .
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, NC 27710; and .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2015 Jan 15; Vol. 194 (2), pp. 790-4. Date of Electronic Publication: 2014 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor*
Gene Rearrangement, delta-Chain T-Cell Antigen Receptor*
Genes, T-Cell Receptor alpha*
Genes, T-Cell Receptor delta*
Genetic Loci*
Promoter Regions, Genetic*
Animals ; Gene Targeting ; Mice ; Thymocytes/cytology
Czasopismo naukowe
Tytuł :
Chromatin Dynamics and the Development of the TCRα and TCRδ Repertoires.
Autorzy :
Carico Z; Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA.
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: .
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Źródło :
Advances in immunology [Adv Immunol] 2015; Vol. 128, pp. 307-61. Date of Electronic Publication: 2015 Aug 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Genes, T-Cell Receptor alpha*
Genes, T-Cell Receptor delta*
V(D)J Recombination*
T-Lymphocytes/*metabolism
Animals ; Chromatin Assembly and Disassembly ; Enhancer Elements, Genetic ; Humans ; T-Lymphocytes/cytology ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Crystallization of the Ets1-Runx1-CBFβ-DNA complex formed on the TCRα gene enhancer.
Autorzy :
Shiina M; Department of Biochemistry, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
Hamada K; Department of Biochemistry, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
Inoue-Bungo T; Department of Biochemistry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
Shimamura M; Department of Biochemistry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
Baba S; Department of Biochemistry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
Sato K; Department of Biochemistry, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
Ogata K; Department of Biochemistry, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
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Źródło :
Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2014 Oct; Vol. 70 (Pt 10), pp. 1380-4. Date of Electronic Publication: 2014 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enhancer Elements, Genetic*
Genes, T-Cell Receptor alpha*
Core Binding Factor Alpha 2 Subunit/*chemistry
Proto-Oncogene Protein c-ets-1/*chemistry
Amino Acid Sequence ; Animals ; Crystallization ; DNA/chemistry ; Humans ; Macromolecular Substances/chemistry ; Mice ; Molecular Sequence Data ; Protein Binding
Czasopismo naukowe
Tytuł :
Endogenous co-expression of two T cell receptors promotes lymphopenia-induced proliferation via increased affinity for self-antigen.
Autorzy :
Balakrishnan A; Department of Pathology, University of California San Diego, La Jolla, California, USA.
Jama B; Department of Pathology, University of California San Diego, La Jolla, California, USA.
Morris GP; Department of Pathology, University of California San Diego, La Jolla, California, USA.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2018 Dec; Vol. 104 (6), pp. 1097-1104. Date of Electronic Publication: 2018 Aug 31.
Typ publikacji :
Journal Article
MeSH Terms :
Lymphocyte Activation*
Autoantigens/*immunology
Lymphopenia/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*immunology
T-Lymphocyte Subsets/*immunology
Adoptive Transfer ; Animals ; CD5 Antigens/biosynthesis ; CD5 Antigens/genetics ; Gene Expression Regulation/immunology ; Genes, T-Cell Receptor alpha ; Genes, T-Cell Receptor beta ; Homeostasis ; Immunologic Memory ; Lymphopenia/genetics ; MAP Kinase Signaling System ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation ; Protein Processing, Post-Translational ; Receptors, Antigen, T-Cell, alpha-beta/deficiency ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Cytokine/immunology ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Tytuł :
Overview of the Germline and Expressed Repertoires of the TRB Genes in Sus scrofa .
Autorzy :
Massari S; Department of Biological and Environmental Science and Technologies, University of Salento, Lecce, Italy.
Bellini M; Department of Biology, University of Bari 'Aldo Moro', Bari, Italy.
Ciccarese S; Department of Biology, University of Bari 'Aldo Moro', Bari, Italy.
Antonacci R; Department of Biology, University of Bari 'Aldo Moro', Bari, Italy.
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Źródło :
Frontiers in immunology [Front Immunol] 2018 Nov 05; Vol. 9, pp. 2526. Date of Electronic Publication: 2018 Nov 05 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, T-Cell Receptor beta/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
T-Lymphocytes/*immunology
Adaptive Immunity/genetics ; Adaptive Immunity/immunology ; Amino Acid Sequence/genetics ; Animals ; Genes, T-Cell Receptor alpha/genetics ; Genome/genetics ; Polymorphism, Single Nucleotide/genetics ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Sus scrofa ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Oxidized fish oil injury stress in Megalobrama amblycephala: Evaluated by growth, intestinal physiology, and transcriptome-based PI3K-Akt/NF-κB/TCR inflammatory signaling.
Autorzy :
Song C; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, China. Electronic address: .
Liu B; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, China. Electronic address: .
Xu P; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, China. Electronic address: .
Xie J; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, China.
Ge X; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, China.
Zhou Q; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, China.
Sun C; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, China.
Zhang H; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China.
Shan F; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China.
Yang Z; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China.
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Źródło :
Fish & shellfish immunology [Fish Shellfish Immunol] 2018 Oct; Vol. 81, pp. 446-455. Date of Electronic Publication: 2018 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Oxidative Stress*
Cyprinidae/*physiology
Fish Oils/*pharmacology
Animals ; Diet ; Genes, T-Cell Receptor alpha ; Lipid Metabolism ; NF-kappa B/genetics ; Oxidation-Reduction ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics
Czasopismo naukowe
Tytuł :
Combined TCRG and TCRA TREC analysis reveals increased peripheral T-lymphocyte but constant intra-thymic proliferative history upon ageing.
Autorzy :
van der Weerd K; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Dik WA
Schrijver B
Bogers AJ
Maat AP
van Nederveen FH
van Hagen PM
van Dongen JJ
Langerak AW
Staal FJ
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Źródło :
Molecular immunology [Mol Immunol] 2013 Mar; Vol. 53 (3), pp. 302-12. Date of Electronic Publication: 2012 Sep 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Genes, T-Cell Receptor alpha*
Genes, T-Cell Receptor gamma*
Aging/*genetics
Aging/*immunology
T-Lymphocytes/*cytology
T-Lymphocytes/*immunology
Adolescent ; Adult ; Aged ; Aging/pathology ; Cell Proliferation ; Child ; Child, Preschool ; Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor ; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor ; Genetic Techniques ; Humans ; Infant, Newborn ; Middle Aged ; Polymerase Chain Reaction ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology ; Thymus Gland/cytology ; Thymus Gland/immunology
Czasopismo naukowe
Tytuł :
NKT and MAIT invariant TCRα sequences can be produced efficiently by VJ gene recombination.
Autorzy :
Greenaway HY; Computational Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, NSW, Australia.
Ng B
Price DA
Douek DC
Davenport MP
Venturi V
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Źródło :
Immunobiology [Immunobiology] 2013 Feb; Vol. 218 (2), pp. 213-24. Date of Electronic Publication: 2012 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, T-Cell Receptor alpha*/genetics
Immunity, Innate*/genetics
Natural Killer T-Cells/*immunology
Animals ; Base Sequence ; Biological Evolution ; Cattle ; Dogs ; Gene Rearrangement, T-Lymphocyte ; Humans ; Macaca mulatta ; Mice ; Mucous Membrane ; Rats ; Sequence Alignment ; Swine ; V(D)J Recombination/genetics
Czasopismo naukowe

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