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Tytuł:
Src-FAK Signaling Mediates Interleukin 6-Induced HCT116 Colorectal Cancer Epithelial-Mesenchymal Transition.
Autorzy:
Huang YH; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Chen HK; Department of General Surgery, Chi Mei Medical Center, Tainan 710, Taiwan.
Hsu YF; Division of General Surgery, Department of Surgery, Landseed Hospital, Taoyuan 324, Taiwan.
Chen HC; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chuang CH; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Huang SW; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Department of Medical Research, Taipei Medical University Hospital, Taipei 110, Taiwan.; Research Center of Thoracic Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan.
Hsu MJ; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei 110, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 02; Vol. 24 (7). Date of Electronic Publication: 2023 Apr 02.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*
Interleukin-6*/metabolism
Humans ; Cell Line, Tumor ; Cell Movement ; Epithelial-Mesenchymal Transition/genetics ; Signal Transduction ; Genes, src
Czasopismo naukowe
Tytuł:
Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo.
Autorzy:
Fan F; Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America.
Ghosh S; Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America.
Powell R; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, College Station, Texas, United States of America.
Roszik J; Melanoma Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America.
Park Y; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, College Station, Texas, United States of America.
Sobieski M; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, College Station, Texas, United States of America.
Sorokin A; Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America.
Stephan C; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, College Station, Texas, United States of America.
Kopetz S; Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America.
Ellis LM; Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America.; Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America.
Bhattacharya R; Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Mar 23; Vol. 18 (3), pp. e0281063. Date of Electronic Publication: 2023 Mar 23 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Colorectal Neoplasms*/pathology
Proto-Oncogene Proteins p21(ras)*
Animals ; Humans ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Dasatinib/pharmacology ; Dasatinib/therapeutic use ; Mitogen-Activated Protein Kinase Kinases ; Protein Kinase Inhibitors/therapeutic use ; Pyridones/pharmacology ; Pyridones/therapeutic use ; Xenograft Model Antitumor Assays ; Genes, src
Czasopismo naukowe
Tytuł:
Phillygenin Attenuated Colon Inflammation and Improved Intestinal Mucosal Barrier in DSS-induced Colitis Mice via TLR4/Src Mediated MAPK and NF-κB Signaling Pathways.
Autorzy:
Xue HH; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Li JJ; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Li SF; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Guo J; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Yan RP; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Chen TG; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Shi XH; Shanxi Institute of Medicine and Life Science, Taiyuan 030006, China.
Wang JD; Shanxi Institute of Medicine and Life Science, Taiyuan 030006, China.
Zhang LW; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 23; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 23.
Typ publikacji:
Journal Article
MeSH Terms:
Colitis*/chemically induced
Colitis*/drug therapy
Colitis*/pathology
Colitis, Ulcerative*/chemically induced
Colitis, Ulcerative*/drug therapy
Colitis, Ulcerative*/pathology
Animals ; Mice ; Antiporters/metabolism ; Colon/pathology ; Dextran Sulfate/toxicity ; Inflammation/metabolism ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Signal Transduction ; Sulfate Transporters/metabolism ; Toll-Like Receptor 4/metabolism ; Genes, src ; Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł:
Polyphyllin VII attenuated RANKL-induced osteoclast differentiation via inhibiting of TRAF6/c-Src/PI3K pathway and ROS production.
Autorzy:
Zhou L; Department of Orthopedics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning Province, China.
Song H; Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, China.
Zhang Y; Department of Orthopedics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning Province, China.
Ren Z; Department of Orthopedics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning Province, China.
Li M; Department of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Fu Q; Department of Orthopedics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning Province, China. fuqin_.
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Źródło:
BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2020 Feb 19; Vol. 21 (1), pp. 112. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji:
Journal Article
MeSH Terms:
Genes, src/*physiology
Osteoclasts/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
RANK Ligand/*pharmacology
Reactive Oxygen Species/*metabolism
Saponins/*toxicity
TNF Receptor-Associated Factor 6/*metabolism
Animals ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Genes, src/drug effects ; Mice ; Mice, Inbred ICR ; Osteoclasts/drug effects ; Reactive Oxygen Species/antagonists & inhibitors ; Signal Transduction/drug effects ; Signal Transduction/physiology ; TNF Receptor-Associated Factor 6/antagonists & inhibitors
Czasopismo naukowe
Tytuł:
Cten promotes Epithelial-Mesenchymal Transition (EMT) in colorectal cancer through stabilisation of Src.
Autorzy:
Asiri A; Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, Queen's Medical Centre, The University of Nottingham, Nottingham, UK.; Medical Genomics Research Department, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs (MNGH), Riyadh, Saudi Arabia.
Toss MS; Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, UK.
Raposo TP; Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, Queen's Medical Centre, The University of Nottingham, Nottingham, UK.
Akhlaq M; Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, UK.
Thorpe H; Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, Queen's Medical Centre, The University of Nottingham, Nottingham, UK.
Alfahed A; Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, Queen's Medical Centre, The University of Nottingham, Nottingham, UK.; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Asiri A; Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, Queen's Medical Centre, The University of Nottingham, Nottingham, UK.
Ilyas M; Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, Queen's Medical Centre, The University of Nottingham, Nottingham, UK.
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Źródło:
Pathology international [Pathol Int] 2019 Jul; Vol. 69 (7), pp. 381-391. Date of Electronic Publication: 2019 Jul 09.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Genes, src*
Colorectal Neoplasms/*pathology
Epithelial-Mesenchymal Transition/*genetics
Tensins/*genetics
Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/physiology ; Colorectal Neoplasms/genetics ; Gene Knockdown Techniques ; Humans ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism
Czasopismo naukowe
Tytuł:
IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation.
Autorzy:
Tong L; Institute for Memory Impairments and Neurological Disorders, University of California, 1226 Gillespie Neuroscience Research Facility, Irvine, CA, 92697, USA. .
Prieto GA; Institute for Memory Impairments and Neurological Disorders, University of California, 1226 Gillespie Neuroscience Research Facility, Irvine, CA, 92697, USA.
Cotman CW; Institute for Memory Impairments and Neurological Disorders, University of California, 1226 Gillespie Neuroscience Research Facility, Irvine, CA, 92697, USA.; Department of Neurobiology and Behavior, University of California, 1226 Gillespie Neuroscience Research Facility, Irvine, CA, 92697, USA.
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2018 Apr 30; Vol. 15 (1), pp. 127. Date of Electronic Publication: 2018 Apr 30.
Typ publikacji:
Journal Article
MeSH Terms:
Actins/*metabolism
Ceramides/*pharmacology
Genes, src/*physiology
Interleukin-1beta/*pharmacology
Long-Term Potentiation/*physiology
Receptors, AMPA/*biosynthesis
Animals ; Cells, Cultured ; Gene Expression ; Genes, src/drug effects ; Hippocampus/drug effects ; Hippocampus/metabolism ; Long-Term Potentiation/drug effects ; Polymerization/drug effects ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/antagonists & inhibitors
Czasopismo naukowe
Tytuł:
Chemical Chaperone of Endoplasmic Reticulum Stress Inhibits Epithelial-Mesenchymal Transition Induced by TGF- β 1 in Airway Epithelium via the c-Src Pathway.
Autorzy:
Lee HM; Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea.; Department of Biomedical Sciences, Korea University Graduate School, Seoul, Republic of Korea.; Medical Devices Clinical Trial Center, Guro Hospital, Korea University, Seoul, Republic of Korea.
Kang JH; Department of Biomedical Sciences, Korea University Graduate School, Seoul, Republic of Korea.
Shin JM; Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea.
Lee SA; Medical Devices Clinical Trial Center, Guro Hospital, Korea University, Seoul, Republic of Korea.
Park IH; Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea.; Medical Devices Clinical Trial Center, Guro Hospital, Korea University, Seoul, Republic of Korea.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2017; Vol. 2017, pp. 8123281. Date of Electronic Publication: 2017 Jul 19.
Typ publikacji:
Journal Article
MeSH Terms:
Endoplasmic Reticulum Stress/*drug effects
Epithelial-Mesenchymal Transition/*drug effects
Genes, src/*physiology
Transforming Growth Factor beta1/*pharmacology
A549 Cells ; Cell Movement/drug effects ; Endoplasmic Reticulum Chaperone BiP ; Genes, src/genetics ; Humans ; Nasal Polyps/metabolism ; Organ Culture Techniques ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis.
Autorzy:
Ito T; Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan.
Taniguchi H; Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan.
Fukagai K; Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan.
Okamuro S; Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan.
Kobayashi A; Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan.
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Źródło:
PloS one [PLoS One] 2015 Feb 13; Vol. 10 (2), pp. e0118336. Date of Electronic Publication: 2015 Feb 13 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression*
Genes, src*
Actins/*metabolism
Cadherins/*genetics
Cell Transformation, Neoplastic/*genetics
Cell Transformation, Neoplastic/*metabolism
Tumor Suppressor Proteins/*genetics
Actin Depolymerizing Factors/metabolism ; Actins/chemistry ; Acyltransferases ; Adaptor Proteins, Signal Transducing/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; MAP Kinase Signaling System ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Multimerization ; Transcription Factors/metabolism ; Transcriptional Activation ; Transduction, Genetic ; YAP-Signaling Proteins
Czasopismo naukowe
Tytuł:
Src mutation induces acquired lapatinib resistance in ERBB2-amplified human gastroesophageal adenocarcinoma models.
Autorzy:
Hong YS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Kim J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Pectasides E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America; Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
Fox C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
Hong SW; Innovative Cancer Research, Asan Institute for Life Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ma Q; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
Wong GS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
Peng S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Stachler MD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Thorner AR; Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
Van Hummelen P; Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
Bass AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Oct 28; Vol. 9 (10), pp. e109440. Date of Electronic Publication: 2014 Oct 28 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, src*
Mutation*
Adenocarcinoma/*genetics
Drug Resistance, Neoplasm/*genetics
Esophageal Neoplasms/*genetics
Receptor, ErbB-2/*genetics
Stomach Neoplasms/*genetics
Adenocarcinoma/drug therapy ; Antineoplastic Agents/pharmacology ; Benzodioxoles/pharmacology ; Cell Line, Tumor ; DNA Mutational Analysis ; Dose-Response Relationship, Drug ; Esophageal Neoplasms/drug therapy ; Gene Amplification ; Gene Expression ; Gene Silencing ; Humans ; Lapatinib ; Protein Kinase Inhibitors/pharmacology ; Quinazolines/pharmacology ; RNA Interference ; Stomach Neoplasms/drug therapy
Czasopismo naukowe
Tytuł:
Lipopolysaccharide-Induced Matrix Metalloproteinase-9 Expression Associated with Cell Migration in Rat Brain Astrocytes.
Autorzy:
Yang CC; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Tao-Yuan, Kwei-San, Tao-Yuan 33302, Taiwan.; School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan 33302, Taiwan.
Lin CC; Department of Anesthetics, Chang Gung Memorial Hospital at Linkuo, Kwei-San, Tao-Yuan 33302, Taiwan.
Hsiao LD; Department of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Kuo JM; Department of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Tseng HC; Department of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Yang CM; Department of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.; Department of Post-Baccalaureate Veterinary Medicine, College of Medical and Health Science, Asia University, Wufeng, Taichung 41354, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Dec 30; Vol. 21 (1). Date of Electronic Publication: 2019 Dec 30.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes/*metabolism
Brain/*metabolism
Cell Movement/*physiology
Lipopolysaccharides/*adverse effects
Matrix Metalloproteinase 9/*metabolism
Animals ; Focal Adhesion Kinase 2 ; Genes, src ; Humans ; MAP Kinase Kinase 4/metabolism ; Matrix Metalloproteinase 9/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger/metabolism ; RNA, Small Interfering ; Rats ; Receptors, Platelet-Derived Growth Factor/metabolism ; Signal Transduction ; Toll-Like Receptor 4/metabolism ; Transcription Factor AP-1/metabolism ; Transfection ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł:
The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis.
Autorzy:
Tateno T; Ontario Cancer Institute, University Health Network, Toronto, Canada.
Asa SL
Zheng L
Mayr T
Ullrich A
Ezzat S
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Źródło:
PLoS genetics [PLoS Genet] 2011 Dec; Vol. 7 (12), pp. e1002400. Date of Electronic Publication: 2011 Dec 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, src*
Cell Transformation, Neoplastic/*genetics
Growth Hormone/*genetics
Pituitary Neoplasms/*genetics
Receptor, Fibroblast Growth Factor, Type 4/*genetics
STAT3 Transcription Factor/*genetics
Serine/*genetics
Animals ; Dasatinib ; Gene Expression Regulation, Neoplastic ; Gene Knock-In Techniques ; Growth Hormone/metabolism ; Humans ; Mice ; Mitochondria/genetics ; Phosphorylation ; Pituitary Neoplasms/metabolism ; Pituitary Neoplasms/pathology ; Polymorphism, Single Nucleotide ; Prolactin/genetics ; Prolactin/metabolism ; Pyrimidines/pharmacology ; Rats ; Receptor, Fibroblast Growth Factor, Type 4/metabolism ; STAT3 Transcription Factor/metabolism ; Serine/metabolism ; Thiazoles/pharmacology
Czasopismo naukowe
Tytuł:
From Rous sarcoma virus to plasminogen activator, src oncogene and cancer management.
Autorzy:
Sudol M; Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, Danville, PA 17822-2608, USA.
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Źródło:
Oncogene [Oncogene] 2011 Jul 07; Vol. 30 (27), pp. 3003-10. Date of Electronic Publication: 2011 Mar 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Genes, src*
Oncogenes*
Neoplasms/*therapy
Plasminogen Activators/*physiology
Rous sarcoma virus/*physiology
Clinical Trials as Topic ; Humans
Czasopismo naukowe
Tytuł:
A novel ex vivo tumor system identifies Src-mediated invasion and metastasis in mesenchymal tumor cells in non-small cell lung cancer.
Autorzy:
Padhye A; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
Ungewiss C; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Fradette JJ; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Rodriguez BL; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Albritton JL; Department of Bioengineering, Rice University, Houston, Texas, USA.
Miller JS; Department of Bioengineering, Rice University, Houston, Texas, USA.
Gibbons DL; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. .; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Mar 20; Vol. 9 (1), pp. 4819. Date of Electronic Publication: 2019 Mar 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*genetics
Epithelial-Mesenchymal Transition/*genetics
Genes, src/*genetics
Lung Neoplasms/*genetics
Neoplasm Invasiveness/*genetics
Neoplasm Metastasis/*genetics
Animals ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Culture Techniques ; Cell Line, Tumor ; Extracellular Matrix/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Lung Neoplasms/pathology ; Mice ; Neoplasm Invasiveness/pathology ; Neoplasm Metastasis/pathology ; Rats ; Signal Transduction/genetics ; Spheroids, Cellular/pathology ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł:
CD99 Expression in Glioblastoma Molecular Subtypes and Role in Migration and Invasion.
Autorzy:
Cardoso LC; Laboratory of Molecular and Cellular Biology (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil. .
Soares RDS; Laboratory of Molecular and Cellular Biology (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil. .
Laurentino TS; Laboratory of Molecular and Cellular Biology (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil. .
Lerario AM; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA. .
Marie SKN; Laboratory of Molecular and Cellular Biology (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil. .
Oba-Shinjo SM; Laboratory of Molecular and Cellular Biology (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Mar 06; Vol. 20 (5). Date of Electronic Publication: 2019 Mar 06.
Typ publikacji:
Journal Article
MeSH Terms:
Up-Regulation*
12E7 Antigen/*genetics
12E7 Antigen/*metabolism
Brain Neoplasms/*genetics
Gene Expression Profiling/*methods
Glioblastoma/*genetics
Brain Neoplasms/metabolism ; Cell Line, Tumor ; Cell Movement ; Focal Adhesion Kinase 1/genetics ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Genes, src/genetics ; Glioblastoma/metabolism ; Humans ; Neoplasm Invasiveness ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Small Interfering/pharmacology ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł:
Adenosine diphosphate regulates MMP2 and MMP9 activity in malignant mesothelioma cells.
Autorzy:
Muscella A; Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy.
Cossa LG; Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy.
Vetrugno C; Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy.
Antonaci G; Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy.
Marsigliante S; Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy.
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Źródło:
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2018 Nov; Vol. 1431 (1), pp. 72-84. Date of Electronic Publication: 2018 Jul 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenosine Diphosphate/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Lung Neoplasms/*metabolism
Matrix Metalloproteinase 2/*metabolism
Matrix Metalloproteinase 9/*metabolism
Mesothelioma/*metabolism
Cell Line, Tumor ; Genes, src/physiology ; Humans ; Mesothelioma, Malignant ; NF-kappa B/metabolism ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł:
SRC gene expression in human cancer: the role of transcriptional activation.
Autorzy:
Dehm SM; Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada. />Bonham K
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Źródło:
Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2004 Apr; Vol. 82 (2), pp. 263-74.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Genes, src*
Transcriptional Activation*
Neoplasms/*genetics
Animals ; Base Sequence ; DNA ; Humans ; Molecular Sequence Data ; Oncogene Protein pp60(v-src)/genetics ; Proto-Oncogene Proteins pp60(c-src)/genetics
Czasopismo naukowe
Tytuł:
EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation.
Autorzy:
Jiang K; Drug Discovery Program, H Lee Moffitt Cancer Center & Research Institute, Department of Interdisciplinary Oncology and Biochemistry, University of South Florida, Tampa, FL 33612, USA.
Delarue FL
Sebti SM
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Źródło:
Oncogene [Oncogene] 2004 Feb 05; Vol. 23 (5), pp. 1136-45.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Cell Transformation, Neoplastic*
Genes, src*
ErbB Receptors/*metabolism
Genes, erbB-2/*physiology
Genes, ras/*physiology
rhoB GTP-Binding Protein/*metabolism
Animals ; Anoikis/genetics ; Antimetabolites, Antineoplastic/pharmacology ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; ErbB Receptors/genetics ; Female ; Fluorouracil/pharmacology ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Genes, erbB-2/genetics ; Genes, ras/genetics ; Humans ; Lung Neoplasms/genetics ; Mice ; NIH 3T3 Cells ; Pancreatic Neoplasms/genetics ; Uterine Cervical Neoplasms/genetics
Czasopismo naukowe
Tytuł:
Identification of Src transformation fingerprint in human colon cancer.
Autorzy:
Malek RL; Department of Functional Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland, MD 20850, USA.
Irby RB
Guo QM
Lee K
Wong S
He M
Tsai J
Frank B
Liu ET
Quackenbush J
Jove R
Yeatman TJ
Lee NH
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Źródło:
Oncogene [Oncogene] 2002 Oct 17; Vol. 21 (47), pp. 7256-65.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Cell Transformation, Neoplastic*
Genes, src*
Colonic Neoplasms/*genetics
Animals ; Cell Line, Transformed ; Cluster Analysis ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Pyridones/pharmacology ; Pyrimidines/pharmacology ; Rats ; Reverse Transcriptase Polymerase Chain Reaction ; Up-Regulation
Czasopismo naukowe
Tytuł:
The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases.
Autorzy:
Kostyniuk CL; Department of Biochemistry, University of Saskatchewan, Saskatoon SK, Canada S7N 5E5.
Dehm SM
Batten D
Bonham K
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Źródło:
Oncogene [Oncogene] 2002 Sep 12; Vol. 21 (41), pp. 6340-7.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, src*
Enzyme Inhibitors/*pharmacology
Gene Expression Regulation/*drug effects
Hydroxamic Acids/*pharmacology
Protein Synthesis Inhibitors/*pharmacology
Dose-Response Relationship, Drug ; Histone Deacetylase Inhibitors ; Humans ; Organ Specificity ; Promoter Regions, Genetic/drug effects ; Promoter Regions, Genetic/genetics
Czasopismo naukowe

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