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Wyszukujesz frazę ""Genes tumor suppressor"" wg kryterium: Temat


Tytuł :
Bona Fide Tumor Suppressor Genes Hypermethylated in Melanoma: A Narrative Review.
Autorzy :
Güvenç C; Department of Dermatology, University Hospitals Leuven, 3000 Leuven, Belgium.
Neckebroeck F; Department of Dermatology, University Hospitals Leuven, 3000 Leuven, Belgium.
Antoranz A; Department of Imaging and Pathology, Translational Cell and Tissue Research, University Hospitals Leuven, 3000 Leuven, Belgium.
Garmyn M; Department of Dermatology, University Hospitals Leuven, 3000 Leuven, Belgium.
van den Oord J; Department of Imaging and Pathology, Translational Cell and Tissue Research, University Hospitals Leuven, 3000 Leuven, Belgium.
Bosisio FM; Department of Imaging and Pathology, Translational Cell and Tissue Research, University Hospitals Leuven, 3000 Leuven, Belgium.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 01; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Methylation*
Gene Expression Regulation, Neoplastic*
Genes, Tumor Suppressor*
Melanoma/*genetics
Animals ; CpG Islands ; Epigenesis, Genetic ; Epigenomics/methods ; Humans ; Melanoma/metabolism ; Melanoma/pathology
Czasopismo naukowe
Tytuł :
The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.
Autorzy :
Martin TD; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Patel RS; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Cook DR; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Choi MY; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Patil A; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Liang AC; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Li MZ; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Haigis KM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Elledge SJ; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Sep 17; Vol. 373 (6561), pp. 1327-1335. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis*
Gene Silencing*
Genes, Tumor Suppressor*
Immune Evasion*/genetics
Neoplasms, Experimental/*genetics
Neoplasms, Experimental/*immunology
Animals ; CRISPR-Cas Systems ; Cell Line, Tumor ; Chemokine CCL2/metabolism ; Female ; GTP-Binding Protein alpha Subunits, G12-G13/genetics ; GTP-Binding Protein alpha Subunits, G12-G13/metabolism ; Humans ; Mammary Neoplasms, Experimental/genetics ; Mammary Neoplasms, Experimental/immunology ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, SCID ; Neoplasm Transplantation ; Neoplasms, Experimental/pathology ; Selection, Genetic ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Competing Endogenous RNA of Snail and Zeb1 UTR in Therapeutic Resistance of Colorectal Cancer.
Autorzy :
Kim NH; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Song SH; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Choi YH; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Hwang KH; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Yun JS; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Song H; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Cha SY; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Cho SB; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Lee I; Research Division, miRCore, Ann Arbor, MI 48105, USA.
Kim HS; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Yook JI; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 03; Vol. 22 (17). Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Tumor Suppressor*
Colorectal Neoplasms/*metabolism
MicroRNAs/*metabolism
Neoplasm Proteins/*metabolism
RNA, Neoplasm/*metabolism
Snail Family Transcription Factors/*metabolism
Zinc Finger E-box-Binding Homeobox 1/*metabolism
Animals ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy ; Female ; HCT116 Cells ; Humans ; Mice ; Mice, Nude ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; RNA, Neoplasm/genetics ; Snail Family Transcription Factors/genetics ; Zinc Finger E-box-Binding Homeobox 1/genetics
Czasopismo naukowe
Tytuł :
Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance.
Autorzy :
Huang D; Chinese University of Hong Kong and the CUHK-Shenzhen Research Institute, China.
Wang X; Chinese University of Hong Kong and the CUHK-Shenzhen Research Institute, China.
Liu Y; Chinese University of Hong Kong and the CUHK-Shenzhen Research Institute, China.
Huang Z; Chinese University of Hong Kong and the CUHK-Shenzhen Research Institute, China.
Hu X; Chinese University of Hong Kong and the CUHK-Shenzhen Research Institute, China.
Hu W; Chinese University of Hong Kong, China.
Li Q; Chinese University of Hong Kong, China.
Chan H; Chinese University of Hong Kong, China.
Zou Y; Chinese University of Hong Kong, China.
Ho IHT; Chinese University of Hong Kong, China.
Wang Y; Chinese University of Hong Kong, China.
Cheng ASL; Chinese University of Hong Kong, China.
Kang W; Chinese University of Hong Kong, China.
To KF; Chinese University of Hong Kong, China.
Wang MHT; Chinese University of Hong Kong and the CUHK-Shenzhen Research Institute, China.
Wong SH; Chinese University of Hong Kong, China.
Yu J; Chinese University of Hong Kong, China.
Gin T; Chinese University of Hong Kong, China.
Zhang Q; City University of Hong Kong, China.
Li Z; Peking Union Medical College Hospital, China.
Shen J; Peking Union Medical College Hospital, China.
Zhang L; Chinese University of Hong Kong, China.
Chan MTV; Chinese University of Hong Kong, China.
Liu X; Chinese University of Hong Kong, China.
Wu WKK; Chinese University of Hong Kong and a researcher at the CUHK-Shenzhen Research Institute, China.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Sep 02; Vol. 22 (5).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Evolution, Molecular*
Genes, Tumor Suppressor*
Promoter Regions, Genetic*
Chromatin/*metabolism
Computational Biology/*methods
Drug Resistance, Neoplasm/*genetics
Neoplasms/*genetics
Antineoplastic Agents/therapeutic use ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Chromatin/ultrastructure ; CpG Islands ; DNA Methylation ; Datasets as Topic ; Gene Expression Regulation, Neoplastic ; Gene Ontology ; Humans ; Molecular Sequence Annotation ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Interaction Domains and Motifs ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Tumor suppressor miR-193a-3p enhances efficacy of BRAF/MEK inhibitors in BRAF-mutated colorectal cancer.
Autorzy :
Hiraide S; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Miyagi, Japan.; Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan.
Takahashi M; Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan.; Department of Medical Oncology, Tohoku University Hospital, Miyagi, Japan.
Yoshida Y; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Miyagi, Japan.; Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan.
Yamada H; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Komine K; Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan.; Department of Medical Oncology, Tohoku University Hospital, Miyagi, Japan.
Ishioka C; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Miyagi, Japan.; Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan.; Department of Medical Oncology, Tohoku University Hospital, Miyagi, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3856-3870. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Tumor Suppressor*
Mutation*
Antineoplastic Agents/*pharmacology
Colorectal Neoplasms/*metabolism
Imidazoles/*pharmacology
MicroRNAs/*genetics
MicroRNAs/*metabolism
Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors
Oximes/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins B-raf/*antagonists & inhibitors
Proto-Oncogene Proteins B-raf/*genetics
Pyridones/*pharmacology
Pyrimidinones/*pharmacology
Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cetuximab/pharmacology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Drug Therapy, Combination/methods ; ErbB Receptors/antagonists & inhibitors ; Humans ; Mitogen-Activated Protein Kinase Kinases/metabolism ; RNA, Small Interfering/genetics ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Transfection
Czasopismo naukowe
Tytuł :
Obscurin: A multitasking giant in the fight against cancer.
Autorzy :
Guardia T; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Eason M; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kontrogianni-Konstantopoulos A; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, USA. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2021 Aug; Vol. 1876 (1), pp. 188567. Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Genes, Tumor Suppressor*
Mutation*
Neoplasms/*genetics
Protein-Serine-Threonine Kinases/*metabolism
Rho Guanine Nucleotide Exchange Factors/*metabolism
Animals ; Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; DNA Methylation ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasms/enzymology ; Neoplasms/pathology ; Protein-Serine-Threonine Kinases/genetics ; RNA, Antisense/genetics ; RNA, Antisense/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Rho Guanine Nucleotide Exchange Factors/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Pseudogene ANXA2P2 knockdown shows tumor-suppressive function by inhibition of the PI3K/PKB pathway in glioblastoma cells.
Autorzy :
Ni H; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Zhi R; Department of Gastroenterology, Lianshui County People's Hospital Affiliated to Kangda College of Nanjing Medical University, Huai'an, China.
Zuo J; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Liu W; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Xie P; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Zhi Z; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Aug; Vol. 35 (8), pp. e22824. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockdown Techniques*
Genes, Tumor Suppressor*
Glioblastoma*/genetics
Glioblastoma*/metabolism
Pseudogenes*
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Cell Line, Tumor ; Humans ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics
Czasopismo naukowe
Tytuł :
Genome-wide estrogen receptor β chromatin binding in human colon cancer cells reveals its tumor suppressor activity.
Autorzy :
Indukuri R; Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Jafferali MH; Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.
Song D; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Damdimopoulos A; Bioinformatics and Expression Core, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Hases L; Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Zhao C; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Archer A; Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Williams C; Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Aug 01; Vol. 149 (3), pp. 692-706. Date of Electronic Publication: 2021 Apr 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Genes, Tumor Suppressor*
Genome, Human*
Biomarkers, Tumor/*metabolism
Chromatin/*metabolism
Colonic Neoplasms/*pathology
Estrogen Receptor beta/*metabolism
Apoptosis ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Adhesion ; Cell Movement ; Cell Proliferation ; Chromatin/genetics ; Chromatin Immunoprecipitation ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Estrogen Receptor beta/genetics ; Female ; Genome-Wide Association Study ; Humans ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress.
Autorzy :
Coronel L; Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.
Riege K; Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.
Schwab K; Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.
Förste S; Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.
Häckes D; Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.
Semerau L; Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.
Bernhart SH; Transcriptome Bioinformatics Group, Department of Computer Science and Interdisciplinary Center for Bioinformatics, Leipzig University, Härtelstraße 16-18, 04107 Leipzig, Germany.
Siebert R; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Hoffmann S; Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.
Fischer M; Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 21; Vol. 49 (13), pp. 7437-7456.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Gene Regulatory Networks*
Genes, Tumor Suppressor*
Regulatory Factor X Transcription Factors/*metabolism
Stress, Physiological/*genetics
Tumor Suppressor Protein p53/*metabolism
Animals ; Antibiotics, Antineoplastic/pharmacology ; Apoptosis ; Cell Differentiation/genetics ; Cell Line, Tumor ; DNA/metabolism ; Doxorubicin/pharmacology ; Humans ; Mice ; Neoplasms/genetics ; Neoplasms/mortality ; Prognosis ; Promoter Regions, Genetic ; Regulatory Factor X Transcription Factors/physiology ; Signal Transduction ; Trans-Activators/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł :
miR-101-3p Serves as a Tumor Suppressor for Renal Cell Carcinoma and Inhibits Its Invasion and Metastasis by Targeting EZH2.
Autorzy :
Dong Y; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, 301 Yanchang Road, Jing'an District, Shanghai 200072, China.
Gao Y; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, 301 Yanchang Road, Jing'an District, Shanghai 200072, China.
Xie T; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, 301 Yanchang Road, Jing'an District, Shanghai 200072, China.
Liu H; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, 301 Yanchang Road, Jing'an District, Shanghai 200072, China.
Zhan X; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, 301 Yanchang Road, Jing'an District, Shanghai 200072, China.
Xu Y; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, 301 Yanchang Road, Jing'an District, Shanghai 200072, China.
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Źródło :
BioMed research international [Biomed Res Int] 2021 Jul 07; Vol. 2021, pp. 9950749. Date of Electronic Publication: 2021 Jul 07 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Tumor Suppressor*
Carcinoma, Renal Cell/*genetics
Carcinoma, Renal Cell/*pathology
Kidney Neoplasms/*genetics
Kidney Neoplasms/*pathology
MicroRNAs/*metabolism
Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Diethylhexyl phthalate (DEHP) regulates the proliferation and chemosensitivity of esophageal squamous cell carcinoma cells via regulation of PTEN.
Autorzy :
Zhu J; Department of Gastroenterology, Jingjiang People's Hospital, Jingjiang, Jiangsu, 214500, People's Republic of China.
Zhang X; Department of Central Laboratory, Jingjiang People's Hospital, Jingjiang, Jiangsu, 214500, People's Republic of China.
Wen B; Department of Oncology, Jingjiang Chinese Medicine Hospital, Jingjiang, Jiangsu, 214500, People's Republic of China.
Chen J; Department of Pathology, Jingjiang People's Hospital, Jingjiang, Jiangsu, 214500, People's Republic of China.
Lu Y; Department of Bioinformatics, Nantong University Medical School, Nantong, Jiangsu, 226001, People's Republic of China.
Xu W; Department of Gastroenterology, East Theater General Hospital of PLA, Nanjing, Jiangsu, 210000, People's Republic of China. .
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Źródło :
Human cell [Hum Cell] 2021 Jul; Vol. 34 (4), pp. 1153-1162. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Tumor Suppressor*
Antineoplastic Agents/*pharmacology
Cell Proliferation/*drug effects
Cisplatin/*pharmacology
Diethylhexyl Phthalate/*adverse effects
Endocrine Disruptors/*adverse effects
Esophageal Neoplasms/*genetics
Esophageal Neoplasms/*pathology
Esophageal Squamous Cell Carcinoma/*genetics
Esophageal Squamous Cell Carcinoma/*pathology
Fluorouracil/*pharmacokinetics
Gene Expression Regulation, Neoplastic/*drug effects
PTEN Phosphohydrolase/*genetics
PTEN Phosphohydrolase/*metabolism
Transcription, Genetic/*drug effects
Cell Line, Tumor ; Disease Progression ; Drug Resistance, Neoplasm/drug effects ; Gene Expression/drug effects ; Humans ; Protein Binding ; Transcription Factor HES-1/genetics ; Transcription Factor HES-1/metabolism ; Transcription, Genetic/genetics
Czasopismo naukowe
Tytuł :
S100A14 inhibits cell growth and epithelial-mesenchymal transition (EMT) in prostate cancer through FAT1-mediated Hippo signaling pathway.
Autorzy :
Jiang S; Department of Urology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China.
Zhu Y; Intensive Care Unit, Fujian Provincial Governmental Hospital, Fuzhou, 350001, Fujian, China.
Chen Z; Department of Urology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China.
Huang Z; Department of Urology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China.
Liu B; Department of Urology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China.
Xu Y; Department of Urology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China.
Li Z; Department of Urology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China.
Lin Z; Department of Urology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China.
Li M; Department of Urology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China. .
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Źródło :
Human cell [Hum Cell] 2021 Jul; Vol. 34 (4), pp. 1215-1226. Date of Electronic Publication: 2021 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Tumor Suppressor*
Cadherins/*metabolism
Calcium-Binding Proteins/*physiology
Cell Proliferation/*genetics
Epithelial-Mesenchymal Transition/*genetics
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*pathology
Protein-Serine-Threonine Kinases/*metabolism
Signal Transduction/*genetics
Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Calcium-Binding Proteins/therapeutic use ; Cell Line, Tumor ; Gene Expression/genetics ; Humans ; Male ; Prostatic Neoplasms/therapy
Czasopismo naukowe
Tytuł :
BRN2 is a non-canonical melanoma tumor-suppressor.
Autorzy :
Hamm M; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France.; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France.; Equipes Labellisées Ligue Contre le Cancer, Paris, France.
Sohier P; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France.; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France.; Equipes Labellisées Ligue Contre le Cancer, Paris, France.
Petit V; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France.; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France.; Equipes Labellisées Ligue Contre le Cancer, Paris, France.
Raymond JH; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France.; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France.; Equipes Labellisées Ligue Contre le Cancer, Paris, France.
Delmas V; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France.; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France.; Equipes Labellisées Ligue Contre le Cancer, Paris, France.
Le Coz M; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France.; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France.; Equipes Labellisées Ligue Contre le Cancer, Paris, France.
Gesbert F; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France.; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France.; Equipes Labellisées Ligue Contre le Cancer, Paris, France.
Kenny C; Department of Anatomy and Cell biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Aktary Z; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France.; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France.; Equipes Labellisées Ligue Contre le Cancer, Paris, France.
Pouteaux M; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France.; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France.; Equipes Labellisées Ligue Contre le Cancer, Paris, France.
Rambow F; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France.; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France.; Equipes Labellisées Ligue Contre le Cancer, Paris, France.
Sarasin A; Laboratory of Genetic Instability and Oncogenesis, UMR8200 CNRS, Gustave Roussy, Université Paris-Sud, Villejuif, France.
Charoenchon N; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France.; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France.; Equipes Labellisées Ligue Contre le Cancer, Paris, France.; Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Bellacosa A; Cancer Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Sanchez-Del-Campo L; Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, UK.
Mosteo L; Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, UK.
Lauss M; Department of Oncology, Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden.
Meijer D; Centre of Neuroregeneration, University of Edinburgh, Edinburgh, UK.
Steingrimsson E; Department of Biochemistry and Molecular Biology, and Department of Anatomy, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Jönsson GB; Department of Oncology, Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden.
Cornell RA; Department of Anatomy and Cell biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Davidson I; Department of Anatomy and Cell biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/UNISTRA, 1 Rue Laurent Fries, 67404, Illkirch, Cedex, France.
Goding CR; Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, UK. .
Larue L; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Normal and Pathological Development of Melanocytes, Orsay, France. .; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation radiobiologie et cancer, Orsay, France. .; Equipes Labellisées Ligue Contre le Cancer, Paris, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 17; Vol. 12 (1), pp. 3707. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Tumor Suppressor*
Carcinogenesis/*metabolism
Cell Proliferation/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Homeodomain Proteins/*metabolism
Melanoma/*metabolism
POU Domain Factors/*metabolism
Skin Neoplasms/*metabolism
Animals ; Carcinogenesis/genetics ; Cell Line, Tumor ; Chromatin Immunoprecipitation ; Cohort Studies ; DNA Copy Number Variations ; Disease Progression ; Gene Knockdown Techniques ; Haploinsufficiency ; Homeodomain Proteins/genetics ; Humans ; Immunohistochemistry ; Melanoma/genetics ; Melanoma/mortality ; Melanoma/secondary ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microarray Analysis ; Microphthalmia-Associated Transcription Factor/metabolism ; Mutation ; POU Domain Factors/genetics ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins B-raf/genetics ; RNA, Small Interfering ; Skin Neoplasms/genetics ; Skin Neoplasms/mortality ; Skin Neoplasms/secondary
SCR Disease Name :
Melanoma, Cutaneous Malignant
Czasopismo naukowe
Tytuł :
Identification of Tumor Suppressive Genes Regulated by miR-31-5p and miR-31-3p in Head and Neck Squamous Cell Carcinoma.
Autorzy :
Oshima S; Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Asai S; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.; Department of Otorhinolaryngology/Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Seki N; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Minemura C; Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Kinoshita T; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.; Department of Otorhinolaryngology/Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Goto Y; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Kikkawa N; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.; Department of Otorhinolaryngology/Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Moriya S; Department of Biochemistry and Genetics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Kasamatsu A; Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Hanazawa T; Department of Otorhinolaryngology/Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Uzawa K; Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 08; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Genes, Tumor Suppressor*
Biomarkers, Tumor/*metabolism
Head and Neck Neoplasms/*pathology
MicroRNAs/*genetics
Squamous Cell Carcinoma of Head and Neck/*pathology
Biomarkers, Tumor/genetics ; Cell Proliferation ; Gene Expression Profiling ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Humans ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Survival Rate ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Roles of the BAP1 Tumor Suppressor in Cell Metabolism.
Autorzy :
Han A; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Purwin TJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Aplin AE; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania. .; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
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Źródło :
Cancer research [Cancer Res] 2021 Jun 01; Vol. 81 (11), pp. 2807-2814. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genes, Tumor Suppressor*
Germ-Line Mutation*
Homeostasis*
Neoplasms/*pathology
Tumor Suppressor Proteins/*metabolism
Ubiquitin Thiolesterase/*metabolism
Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Tumor Suppressor Proteins/genetics ; Ubiquitin Thiolesterase/genetics
Czasopismo naukowe
Tytuł :
Molecular Mechanisms of miR-1271 Dysregulation in Human Cancer.
Autorzy :
Zhou K; Gastroenterology Department, Ningbo No.9 Hospital, Ningbo, China.
Cai C; Emergency Department, Yinzhou No.2 Hospital, Ningbo, China.
Zou M; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, China.
He Y; Gastroenterology Department, Ningbo No.9 Hospital, Ningbo, China.
Duan S; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, China.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2021 Jun; Vol. 40 (6), pp. 740-747. Date of Electronic Publication: 2021 May 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Genes, Tumor Suppressor*
MicroRNAs/*physiology
Neoplasms/*metabolism
Biomarkers, Tumor/physiology ; Humans ; Neoplasms/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Identification of significant genes as prognostic markers and potential tumor suppressors in lung adenocarcinoma via bioinformatical analysis.
Autorzy :
Lu M; Department of Human Resources, General Hospital of Western Theater Command, Chengdu, 610083, China.
Fan X; Department of Thoracic Surgery, General Hospital of Western Theater Command, Chengdu, 610083, China.
Liao W; Department of Thoracic Surgery, General Hospital of Western Theater Command, Chengdu, 610083, China.
Li Y; Department of Anesthesiology, The People's Hospital of Leshan, Leshan, 614000, China.
Ma L; Department of Pulmonary and Critical Care Medicine, General Hospital of Western Theater Command, Chengdu, 610083, China.
Yuan M; Department of Scientific Research & Training, General Hospital of Western Theater Command, Chengdu, 610083, China.
Gu R; Basic Medical Laboratory, General Hospital of Western Theater Command, Chengdu, 610083, China.
Wei Z; Department of Outpatient, General Hospital of Western Theater Command, Chengdu, 610083, China.
Wang C; Department of Pathology, General Hospital of Western Theater Command, NO.270 Tianhui Road, Rongdu Avenue, Jinniu District, Chengdu, 610083, China. .
Zhang H; Department of Pathology, General Hospital of Western Theater Command, NO.270 Tianhui Road, Rongdu Avenue, Jinniu District, Chengdu, 610083, China. .; State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610041, China. .
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Źródło :
BMC cancer [BMC Cancer] 2021 May 26; Vol. 21 (1), pp. 616. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Regulatory Networks*
Genes, Tumor Suppressor*
Adenocarcinoma of Lung/*genetics
Biomarkers, Tumor/*genetics
Lung Neoplasms/*genetics
Adenocarcinoma of Lung/mortality ; Computational Biology ; Databases, Genetic ; Datasets as Topic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/mortality ; Microarray Analysis ; Prognosis ; Protein Interaction Mapping ; Protein Interaction Maps/genetics
Czasopismo naukowe
Tytuł :
Molecular pathogenesis of breast cancer: impact of miR-99a-5p and miR-99a-3p regulation on oncogenic genes.
Autorzy :
Shinden Y; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Hirashima T; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Nohata N; MSD K.K., Tokyo, Japan.
Toda H; Department of Breast Surgery, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan.
Okada R; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, 260-8670, Japan.
Asai S; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, 260-8670, Japan.
Tanaka T; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Hozaka Y; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Ohtsuka T; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Kijima Y; Department of Breast Surgery, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan.
Seki N; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, 260-8670, Japan. .
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Źródło :
Journal of human genetics [J Hum Genet] 2021 May; Vol. 66 (5), pp. 519-534. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Estrogens*
Genes, Tumor Suppressor*
Oncogenes*
Progesterone*
Breast Neoplasms/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Intracellular Signaling Peptides and Proteins/*genetics
MicroRNAs/*genetics
Neoplasm Proteins/*genetics
Neoplasms, Hormone-Dependent/*genetics
Nuclear Proteins/*genetics
RNA, Neoplasm/*genetics
Aminopyridines/administration & dosage ; Aminopyridines/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Benzimidazoles/administration & dosage ; Benzimidazoles/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Down-Regulation ; Female ; Genes, erbB-2 ; Humans ; Intracellular Signaling Peptides and Proteins/biosynthesis ; Intracellular Signaling Peptides and Proteins/physiology ; Kaplan-Meier Estimate ; MicroRNAs/physiology ; Middle Aged ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/physiology ; Neoplasms, Hormone-Dependent/drug therapy ; Neoplasms, Hormone-Dependent/mortality ; Neoplasms, Hormone-Dependent/pathology ; Nuclear Proteins/biosynthesis ; Nuclear Proteins/physiology ; Piperazines/administration & dosage ; Piperazines/therapeutic use ; Prognosis ; Progression-Free Survival ; Pyridines/administration & dosage ; Pyridines/therapeutic use ; RNA Interference ; RNA, Neoplasm/physiology ; RNA, Small Interfering/genetics ; Treatment Outcome
Czasopismo naukowe
Tytuł :
MIR99AHG is a noncoding tumor suppressor gene in lung adenocarcinoma.
Autorzy :
Han C; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
Li H; Department of Thoracic Surgery, the Third Affiliated Hospital of Soochow University, Changzhou, China.; Department of Thoracic Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ma Z; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
Dong G; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
Wang Q; Department of Thoracic Surgery, the Third Affiliated Hospital of Soochow University, Changzhou, China.
Wang S; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
Fang P; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
Li X; Department of Thoracic Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Chen H; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
Liu T; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.; Department of Science and technology, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
Xu L; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
Wang J; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China. .; Department of Science and technology, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China. .; Biobank of Lung Cancer, Jiangsu Biobank of Clinical Resources, Nanjing, China. .
Wang J; Department of Thoracic Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. .
Yin R; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China. .; Department of Science and technology, the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China. .; Biobank of Lung Cancer, Jiangsu Biobank of Clinical Resources, Nanjing, China. .; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China. .
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Źródło :
Cell death & disease [Cell Death Dis] 2021 Apr 30; Vol. 12 (5), pp. 424. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Tumor Suppressor*
Adenocarcinoma of Lung/*genetics
Lung Neoplasms/*genetics
MicroRNAs/*genetics
Adenocarcinoma of Lung/pathology ; Animals ; Cell Movement/physiology ; Cell Proliferation/physiology ; Humans ; Lung Neoplasms/pathology ; Mice ; Mice, Nude
Czasopismo naukowe
Tytuł :
Genome-Wide Methylation Mapping Using Nanopore Sequencing Technology Identifies Novel Tumor Suppressor Genes in Hepatocellular Carcinoma.
Autorzy :
Davenport CF; Research Core Unit Genomics OE 9415, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623 Hannover, Germany.
Scheithauer T; Research Core Unit Genomics OE 9415, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623 Hannover, Germany.
Dunst A; Institut fuer Zellbiochemie, OE4310, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623 Hannover, Germany.
Bahr FS; Institut fuer Zellbiochemie, OE4310, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623 Hannover, Germany.
Dorda M; Research Core Unit Genomics OE 9415, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623 Hannover, Germany.
Wiehlmann L; Research Core Unit Genomics OE 9415, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623 Hannover, Germany.
Tran DDH; Institut fuer Zellbiochemie, OE4310, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623 Hannover, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 11; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 11.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
DNA Methylation*
DNA, Neoplasm*/genetics
DNA, Neoplasm*/metabolism
Genes, Tumor Suppressor*
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Nanopore Sequencing*
Genome-Wide Association Study ; Hep G2 Cells ; Humans
Czasopismo naukowe

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