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Wyszukujesz frazę ""Genetic"" wg kryterium: Temat


Tytuł :
Evaluating the estimation of genetic correlation and heritability using summary statistics.
Autorzy :
Zhang J; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA. .
Schumacher FR; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
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Źródło :
Molecular genetics and genomics : MGG [Mol Genet Genomics] 2021 Nov; Vol. 296 (6), pp. 1221-1234. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Genetic*
Quantitative Trait, Heritable*
Genetic Predisposition to Disease/*genetics
Computer Simulation ; Genetic Background ; Genome-Wide Association Study ; Humans ; Neoplasms/genetics ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study.
Autorzy :
Furniss CS; Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.
Yurgelun MB; Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Brigham and Women's Hospital, Boston, Massachusetts.
Ukaegbu C; Dana-Farber Cancer Institute, Boston, Massachusetts.
Constantinou PE; Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas, MD Anderson Cancer Center, Houston, Texas.
Lafferty CC; Dana-Farber Cancer Institute, Boston, Massachusetts.
Talcove-Berko ER; Dana-Farber Cancer Institute, Boston, Massachusetts.
Schwartz AN; Dana-Farber Cancer Institute, Boston, Massachusetts.
Stopfer JE; Dana-Farber Cancer Institute, Boston, Massachusetts.
Underhill-Blazey M; Dana-Farber Cancer Institute, Boston, Massachusetts.
Kenner B; Kenner Family Research Fund, New York, New York.
Nelson SH; Pancreatic Cancer Action Network Volunteer, Patient Advocate, and Pancreatic Cancer Survivor, St. Anthony, Minnesota.
Okumura S; Color Genomics, Burlingame, California.
Law S; Color Genomics, Burlingame, California.
Zhou AY; Color Genomics, Burlingame, California.
Coffin TB; University of Washington, Seattle, Washington.
Rodriguez NJ; Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Brigham and Women's Hospital, Boston, Massachusetts.
Uno H; Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.
Ocean AJ; Weill Cornell Medical Center, New York, New York.
McAllister F; Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas, MD Anderson Cancer Center, Houston, Texas.
Lowy AM; Moores Cancer Center, UC San Diego, San Diego, California.
Lippman SM; Moores Cancer Center, UC San Diego, San Diego, California.
Klein AP; Johns Hopkins University, Sol Goldman Pancreatic Cancer Research Center, Baltimore, Maryland.
Madlensky L; Moores Cancer Center, UC San Diego, San Diego, California.
Petersen GM; Mayo Clinic, Rochester, Minnesota.
Garber JE; Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Brigham and Women's Hospital, Boston, Massachusetts.
Goggins MG; Johns Hopkins University, Sol Goldman Pancreatic Cancer Research Center, Baltimore, Maryland.
Maitra A; Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas, MD Anderson Cancer Center, Houston, Texas.
Syngal S; Dana-Farber Cancer Institute, Boston, Massachusetts. .; Harvard Medical School, Boston, Massachusetts.; Brigham and Women's Hospital, Boston, Massachusetts.
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Źródło :
Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2021 Nov; Vol. 14 (11), pp. 1021-1032. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Germ-Line Mutation*
BRCA1 Protein/*genetics
BRCA2 Protein/*genetics
Genetic Testing/*methods
Pancreatic Neoplasms/*genetics
Risk Assessment/*methods
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/therapy ; Female ; Humans ; Male ; Middle Aged ; Models, Genetic ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/therapy ; Patient Participation ; Risk Factors ; Surveys and Questionnaires ; Telemedicine ; Young Adult
Czasopismo naukowe
Tytuł :
Human TERT promoter polymorphism rs2853669 is associated with cancers: an updated meta-analysis.
Autorzy :
Aziz MA; Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh.
Jafrin S; Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh.
Islam MS; Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh. .
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Źródło :
Human cell [Hum Cell] 2021 Jul; Vol. 34 (4), pp. 1066-1081. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Genetic Association Studies*
Genetic Predisposition to Disease/*genetics
Neoplasms/*genetics
Polymorphism, Genetic/*genetics
Telomerase/*genetics
Asian Continental Ancestry Group/genetics ; Humans ; Lung Neoplasms/genetics ; Lymphoma/genetics ; Models, Genetic ; Promoter Regions, Genetic/genetics ; Risk
Czasopismo naukowe
Tytuł :
From variant to function in human disease genetics.
Autorzy :
Lappalainen T; Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden.; New York Genome Center, New York, NY, USA.
MacArthur DG; Centre for Population Genomics, Garvan Institute of Medical Research, and UNSW Sydney, Sydney, New South Wales, Australia.; Centre for Population Genomics, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Sep 24; Vol. 373 (6562), pp. 1464-1468. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Genetic Techniques*
Genetic Variation*
Genome, Human*
Genomics*
Disease/*genetics
Genetic Diseases, Inborn/*genetics
Gene Expression Regulation ; Genetic Diseases, Inborn/diagnosis ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Molecular Sequence Annotation ; Multifactorial Inheritance/genetics ; Phenotype ; Quantitative Trait Loci
Czasopismo naukowe
Tytuł :
Genetic and Epigenetic Factors of Takotsubo Syndrome: A Systematic Review.
Autorzy :
Ferradini V; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Vacca D; Tumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.
Belmonte B; Tumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.
Mango R; Cardiology Unit, Department of Emergency and Critical Care, Policlinico Tor Vergata, 00133 Rome, Italy.
Scola L; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, 90134 Palermo, Italy.
Novelli G; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Balistreri CR; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, 90134 Palermo, Italy.
Sangiuolo F; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 13; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Genetic Heterogeneity*
Genetic Predisposition to Disease*
COVID-19/*complications
Epigenesis, Genetic/*immunology
Takotsubo Cardiomyopathy/*genetics
Biomarkers/analysis ; COVID-19/immunology ; COVID-19/virology ; DNA Copy Number Variations/immunology ; Genetic Loci/immunology ; Heart Ventricles/immunology ; Heart Ventricles/pathology ; Humans ; Medical History Taking ; Polymorphism, Single Nucleotide/immunology ; SARS-CoV-2/immunology ; Takotsubo Cardiomyopathy/diagnosis ; Takotsubo Cardiomyopathy/immunology ; Takotsubo Cardiomyopathy/pathology
Czasopismo naukowe
Tytuł :
Clinical Multigene Testing for Prostate Cancer.
Autorzy :
Berro T; Division of Genetics, Brigham and Women's Hospital, EC Alumnae Hall, Suite 302, 41 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: https://twitter.com/tala_berro.
Barrett E; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 41 Avenue Louis Pasteur, Suite 303-0, Boston, MA 02115, USA. Electronic address: https://twitter.com/Liz13arrett.
AlDubayan SH; Division of Genetics, Brigham and Women's Hospital, EC Alumnae Hall, Suite 302, 41 Avenue Louis Pasteur, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 41 Avenue Louis Pasteur, Suite 303-0, Boston, MA 02115, USA. Electronic address: .
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Źródło :
The Urologic clinics of North America [Urol Clin North Am] 2021 Aug; Vol. 48 (3), pp. 297-309. Date of Electronic Publication: 2021 Jun 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Predisposition to Disease*
Genetic Testing/*methods
Prostatic Neoplasms/*genetics
Disease Progression ; Genetic Counseling ; Germ-Line Mutation ; Humans ; Male ; Prostatic Neoplasms/ethnology
Czasopismo naukowe
Tytuł :
Viral gene therapy for paediatric neurological diseases: progress to clinical reality.
Autorzy :
Privolizzi R; Gene Transfer Technology Group, EGA Institute for Women's Health, University College London, London, UK.
Chu WS; Pharmacy Department, The Royal Marsden NHS Foundation Trust, London, UK.
Tijani M; Immune Regulation and Tumour Immunotherapy Group, Cancer Institute, University College London, London, UK.
Ng J; Gene Transfer Technology Group, EGA Institute for Women's Health, University College London, London, UK.
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Źródło :
Developmental medicine and child neurology [Dev Med Child Neurol] 2021 Sep; Vol. 63 (9), pp. 1019-1029. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genetic Vectors*
Genetic Diseases, Inborn/*therapy
Genetic Therapy/*methods
Nervous System Diseases/*genetics
Nervous System Diseases/*therapy
Clinical Trials as Topic ; Dependovirus/genetics ; Humans ; Lentivirus/genetics ; Transduction, Genetic/methods ; Transfection/methods
Czasopismo naukowe
Tytuł :
IL-36γ-armed oncolytic virus exerts superior efficacy through induction of potent adaptive antitumor immunity.
Autorzy :
Yang M; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Giehl E; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, TU Dresden, 01307, Dresden, Germany.
Feng C; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Feist M; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Surgery, CCM/CVK, Charité-Universitaetsmedizin Berlin, Berlin, Germany.
Chen H; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Dai E; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Liu Z; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ma C; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ravindranathan R; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Bartlett DL; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; AHN-Cancer Institute, Pittsburgh, PA, USA.
Lu B; UPMC Hillman Cancer Center, Pittsburgh, PA, USA. .; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. .
Guo ZS; UPMC Hillman Cancer Center, Pittsburgh, PA, USA. .; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Sep; Vol. 70 (9), pp. 2467-2481. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptive Immunity*
Genetic Therapy*
Oncolytic Virotherapy*/adverse effects
Oncolytic Virotherapy*/methods
Genetic Vectors/*genetics
Interleukin-1/*genetics
Neoplasms/*immunology
Neoplasms/*therapy
Oncolytic Viruses/*genetics
Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Cells, Cultured ; Cytotoxicity, Immunologic ; Disease Models, Animal ; Gene Expression ; Genetic Engineering ; Genetic Vectors/administration & dosage ; Humans ; Melanoma, Experimental ; Mice ; Molecular Imaging ; Neoplasms/diagnosis ; Neoplasms/genetics ; Treatment Outcome ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Targeted long-read sequencing identifies missing disease-causing variation.
Autorzy :
Miller DE; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA. Electronic address: .
Sulovari A; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Wang T; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Loucks H; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Hoekzema K; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Munson KM; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Lewis AP; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Fuerte EPA; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Paschal CR; Department of Laboratories, Seattle Children's Hospital, Seattle, WA 98105, USA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Walsh T; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Thies J; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Bennett JT; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA; Department of Laboratories, Seattle Children's Hospital, Seattle, WA 98105, USA; Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA.
Glass I; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Dipple KM; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Patterson K; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Bonkowski ES; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Nelson Z; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Squire A; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Sikes M; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Beckman E; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Bennett RL; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Earl D; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Lee W; Department of Genetics and Development, Columbia University, New York, NY 10032, USA; Department of Ophthalmology, Columbia University, New York, NY 10032, USA.
Allikmets R; Department of Ophthalmology, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Perlman SJ; Department of Neurology, Seattle Children's Hospital, University of Washington, Seattle, WA 98105, USA.
Chow P; Department of Pediatrics, Division of Craniofacial Medicine, University of Washington, Seattle, WA 98195, USA.
Hing AV; Department of Pediatrics, Division of Craniofacial Medicine, University of Washington, Seattle, WA 98195, USA.
Wenger TL; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Adam MP; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Sun A; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Lam C; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Chang I; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Zou X; Program in Computational Biology & Bioinformatics, Duke University, Durham, NC 27710, USA.
Austin SL; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC 27708, USA.
Huggins E; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC 27708, USA.
Safi A; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC 27708, USA.
Iyengar AK; Department of Biostatistics and Bioinformatics, Duke University; Durham, NC 27708, USA; University Program in Genetics and Genomics, Duke University; Durham, NC 27708, USA.
Reddy TE; Department of Biostatistics and Bioinformatics, Duke University; Durham, NC 27708, USA.
Majoros WH; Department of Biostatistics and Bioinformatics, Duke University; Durham, NC 27708, USA.
Allen AS; Department of Biostatistics and Bioinformatics, Duke University; Durham, NC 27708, USA.
Crawford GE; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC 27708, USA.
Kishnani PS; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC 27708, USA.
King MC; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Cherry T; Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Chong JX; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA.
Bamshad MJ; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA.
Nickerson DA; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA.
Mefford HC; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA.
Doherty D; Department of Pediatrics, Division of Genetic Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA; Department of Pediatrics, Division of Developmental Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.
Eichler EE; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA. Electronic address: .
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Corporate Authors :
University of Washington Center for Mendelian Genomics
Źródło :
American journal of human genetics [Am J Hum Genet] 2021 Aug 05; Vol. 108 (8), pp. 1436-1449. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Aberrations*
Genetic Predisposition to Disease*
Genome, Human*
Mutation*
Cytogenetic Analysis/*methods
Genetic Diseases, Inborn/*diagnosis
Genetic Diseases, Inborn/*genetics
DNA Copy Number Variations ; Female ; Genetic Testing ; High-Throughput Nucleotide Sequencing ; Humans ; Karyotyping ; Male ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Epistasis shapes the fitness landscape of an allosteric specificity switch.
Autorzy :
Nishikawa KK; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Hoppe N; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Smith R; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Bingman C; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Raman S; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA. .; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA. .; Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 21; Vol. 12 (1), pp. 5562. Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Epistasis, Genetic*
Allosteric Regulation/*genetics
Genetic Fitness/*genetics
Transcription Factors/*genetics
Allosteric Site ; Computer Simulation ; Crystallography, X-Ray ; Evolution, Molecular ; Ligands ; Models, Genetic ; Mutation ; Protein Binding ; Transcription Factors/chemistry ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
An Updated Model for the Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation.
Autorzy :
Xu T; Discipline of Microbiology and Immunology, Center for Cancer Cell Biology, Immunology and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL; and.
Pereira RM; Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil .
Martinez GJ; Discipline of Microbiology and Immunology, Center for Cancer Cell Biology, Immunology and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL; and .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Sep 15; Vol. 207 (6), pp. 1497-1505.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Immunologic Memory*
Models, Genetic*
Cell Differentiation/*genetics
Epigenesis, Genetic/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Cell Differentiation/immunology ; Genetic Heterogeneity ; Humans ; Lymphocyte Activation ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Multi-syndrome, multi-gene risk modeling for individuals with a family history of cancer with the novel R package PanelPRO.
Autorzy :
Lee G; Swiss Data Science Center, ETH Zürich and EPFL, Lausanne, Switzerland.
Liang JW; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States.; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, United States.
Zhang Q; Broad Institute of MIT and Harvard, Cambridge, United States.
Huang T; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States.; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, United States.
Choirat C; Swiss Data Science Center, ETH Zürich and EPFL, Lausanne, Switzerland.
Parmigani G; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States.; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, United States.
Braun D; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States.; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, United States.
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Źródło :
ELife [Elife] 2021 Aug 18; Vol. 10. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genetic Predisposition to Disease*
Software*
Genetic Testing/*methods
Neoplasms/*genetics
Female ; Humans ; Male ; Models, Genetic ; Mutation ; Pedigree ; Syndrome
Czasopismo naukowe
Tytuł :
Challenges of Accuracy in Germline Clinical Sequencing Data.
Autorzy :
Poplin R; Google Inc, Mountain View, California.
Zook JM; Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, Maryland.
DePristo M; BigHat Biosciences, San Carlos, California.
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Źródło :
JAMA [JAMA] 2021 Jul 20; Vol. 326 (3), pp. 268-269.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Variation*
Germ Cells*
High-Throughput Nucleotide Sequencing*
Genetic Testing/*methods
Genetic Diseases, Inborn/diagnosis ; Genome, Human ; Germ-Line Mutation ; Humans
Czasopismo naukowe
Tytuł :
TLR3 (rs3775291) variant is not associated with SARS-CoV-2 infection and related mortality: a population-based correlation analysis.
Autorzy :
Pati A; Department of Bioscience and Bioinformatics, Khallikote University, Konisi, 761008, Berhampur, Odisha, India.
Padhi S; Department of Bioscience and Bioinformatics, Khallikote University, Konisi, 761008, Berhampur, Odisha, India.
Chaudhury S; Department of Bioscience and Bioinformatics, Khallikote University, Konisi, 761008, Berhampur, Odisha, India.
Panda AK; Department of Bioscience and Bioinformatics, Khallikote University, Konisi, 761008, Berhampur, Odisha, India. .
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Źródło :
Human cell [Hum Cell] 2021 Jul; Vol. 34 (4), pp. 1274-1277. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Letter
MeSH Terms :
Genetic Variation*
SARS-CoV-2*
COVID-19/*genetics
COVID-19/*mortality
Genetic Predisposition to Disease/*genetics
Toll-Like Receptor 3/*genetics
Alleles ; Genetics, Population ; Healthy Volunteers ; Humans ; Negative Results ; Polymorphism, Genetic/genetics
Opinia redakcyjna
Tytuł :
A cross-population atlas of genetic associations for 220 human phenotypes.
Autorzy :
Sakaue S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. .; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. .; Center for Data Sciences, Harvard Medical School, Boston, MA, USA. .; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. .; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. .
Kanai M; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Tanigawa Y; Department of Biomedical Data Science, School of Medicine, Stanford University, Stanford, CA, USA.
Karjalainen J; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Kurki M; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Koshiba S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Sendai, Japan.
Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Konuma T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Yamamoto K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.
Akiyama M; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ishigaki K; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Center for Data Sciences, Harvard Medical School, Boston, MA, USA.; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Suzuki A; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Suzuki K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Obara W; Department of Urology, Iwate Medical University, Iwate, Japan.
Yamaji K; Department of Internal Medicine and Rheumatology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Takahashi K; Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Asai S; Division of Pharmacology, Department of Biomedical Science, Nihon University School of Medicine, Tokyo, Japan.; Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, Japan.
Takahashi Y; Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, Japan.
Suzuki T; Tokushukai Group, Tokyo, Japan.
Shinozaki N; Tokushukai Group, Tokyo, Japan.
Yamaguchi H; Department of Hematology, Nippon Medical School, Tokyo, Japan.
Minami S; Department of Bioregulation, Nippon Medical School, Kawasaki, Japan.
Murayama S; Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Yoshimori K; Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Nagayama S; The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Obata D; Center for Clinical Research and Advanced Medicine, Shiga University of Medical Science, Otsu, Japan.
Higashiyama M; Department of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan.
Masumoto A; Aso Iizuka Hospital, Fukuoka, Japan.
Koretsune Y; National Hospital Organization Osaka National Hospital, Osaka, Japan.
Ito K; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Komuro I; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Toranomon Hospital, Tokyo, Japan.
Tamiya G; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Sendai, Japan.; Graduate School of Medicine, Tohoku University, Sendai, Japan.; Center for Advanced Intelligence Project, RIKEN, Tokyo, Japan.
Yamamoto M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Sendai, Japan.; Graduate School of Medicine, Tohoku University, Sendai, Japan.
Nakamura Y; Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Murakami Y; Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yamamoto K; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kamatani Y; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Palotie A; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Analytic and Translational Genetics Unit, Department of Medicine, and the Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Rivas MA; Department of Biomedical Data Science, School of Medicine, Stanford University, Stanford, CA, USA.
Daly MJ; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Matsuda K; Department of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Tokyo, Japan. .
Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. .; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. .; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan. .; Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Analytic and Translational Genetics Unit, Department of Medicine, and the Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. .; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan. .
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Corporate Authors :
FinnGen
Źródło :
Nature genetics [Nat Genet] 2021 Oct; Vol. 53 (10), pp. 1415-1424. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Association Studies*
Genetic Predisposition to Disease*
ABO Blood-Group System/genetics ; Biological Specimen Banks ; Genetic Loci ; Genetic Pleiotropy ; Genome-Wide Association Study ; Humans ; Major Histocompatibility Complex/genetics ; Meta-Analysis as Topic ; Mutation/genetics ; Phenotype
Czasopismo naukowe
Tytuł :
Utility of polygenic embryo screening for disease depends on the selection strategy.
Autorzy :
Lencz T; Departments of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, United States.; Department of Psychiatry, Division of Research, The Zucker Hillside Hospital Division of Northwell Health, Glen Oaks, United States.; Institute for Behavioral Science, The Feinstein Institutes for Medical Research, Manhasset, United States.
Backenroth D; Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Granot-Hershkovitz E; Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Green A; Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Gettler K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
Cho JH; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, United States.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States.
Weissbrod O; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, United States.
Zuk O; Department of Statistics and Data Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
Carmi S; Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
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Źródło :
ELife [Elife] 2021 Oct 12; Vol. 10. Date of Electronic Publication: 2021 Oct 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Fertilization in Vitro*
Genetic Testing*
Models, Genetic*
Multifactorial Inheritance*
Preimplantation Diagnosis*
Crohn Disease/*genetics
Schizophrenia/*genetics
Computer Simulation ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Predictive Value of Tests ; Pregnancy ; Risk Assessment ; Risk Factors
Czasopismo naukowe
Tytuł :
A Novel Cre/ lox -Based Genetic Tool for Repeated, Targeted and Markerless Gene Integration in Yarrowia lipolytica .
Autorzy :
Zhou Q; Key Laboratory of Molecular Biophysics, The Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Jiao L; Key Laboratory of Molecular Biophysics, The Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Li W; Key Laboratory of Molecular Biophysics, The Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Hu Z; Key Laboratory of Molecular Biophysics, The Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Li Y; Key Laboratory of Molecular Biophysics, The Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Zhang H; Key Laboratory of Molecular Biophysics, The Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Yang M; Key Laboratory of Molecular Biophysics, The Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Xu L; Key Laboratory of Molecular Biophysics, The Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Yan Y; Key Laboratory of Molecular Biophysics, The Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 04; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 04.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Editing*
Genetic Vectors*
Fungal Proteins/*genetics
Integrases/*metabolism
Plasmids/*genetics
Yarrowia/*genetics
Genetic Engineering ; Integrases/genetics ; Recombination, Genetic ; Yarrowia/growth & development
Czasopismo naukowe
Tytuł :
Expanded carrier screening for recessively inherited disorders: economic burden and factors in decision-making when one individual in a couple is identified as a carrier.
Autorzy :
Shapiro AJ; Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA, USA. .
Kroener L; Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA, USA.
Quinn MM; Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA, USA.
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Źródło :
Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2021 Apr; Vol. 38 (4), pp. 957-963. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Carrier Screening*
Genetic Diseases, Inborn/*genetics
Infertility/*genetics
Reproductive Techniques/*trends
Clinical Decision-Making ; Cost of Illness ; Family Characteristics ; Female ; Genetic Counseling/economics ; Genetic Counseling/trends ; Genetic Diseases, Inborn/diagnosis ; Genetic Diseases, Inborn/economics ; Genetic Diseases, Inborn/epidemiology ; Genetic Testing/economics ; Genetic Testing/trends ; Humans ; Infertility/epidemiology ; Infertility/pathology ; Male ; Pregnancy ; Prenatal Diagnosis/methods ; Reproduction/genetics
Czasopismo naukowe
Tytuł :
Universal genetic testing of patients with newly diagnosed breast cancer - ready for prime time?
Autorzy :
De Silva DL; Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC.; Memorial Sloan Kettering Cancer Center, New York, USA.
James PA; Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC.; University of Melbourne, Melbourne, VIC.
Mann GB; University of Melbourne, Melbourne, VIC.; Royal Melbourne and Royal Women's Hospitals, Melbourne, VIC.; Peter MacCallum Cancer Centre, Melbourne, VIC.
Lindeman GJ; Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC.; University of Melbourne, Melbourne, VIC.; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC.
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Źródło :
The Medical journal of Australia [Med J Aust] 2021 Nov 15; Vol. 215 (10), pp. 449-453. Date of Electronic Publication: 2021 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Testing*/economics
Breast Neoplasms/*diagnosis
Breast Neoplasms/*genetics
Early Detection of Cancer/*methods
Early Detection of Cancer/economics ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Germ-Line Mutation ; Health Care Costs ; Humans
Czasopismo naukowe
Tytuł :
Allele-specific epigenetic activity in prostate cancer and normal prostate tissue implicates prostate cancer risk mechanisms.
Autorzy :
Shetty A; University of Cambridge, Cambridge CB2 0SP, UK; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
Seo JH; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Bell CA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
O'Connor EP; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
Pomerantz MM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Freedman ML; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA.
Gusev A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address: .
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Źródło :
American journal of human genetics [Am J Hum Genet] 2021 Nov 04; Vol. 108 (11), pp. 2071-2085. Date of Electronic Publication: 2021 Oct 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alleles*
Epigenesis, Genetic*
Genetic Predisposition to Disease*
Prostate/*metabolism
Prostatic Neoplasms/*genetics
Enhancer Elements, Genetic ; Genome-Wide Association Study ; Humans ; Male ; Quantitative Trait Loci
Czasopismo naukowe

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