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Podgląd okładki
Tytuł :
New intranasal and injectable gene therapy for healthy life extension.
Autorzy :
Jaijyan DK; Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103.
Selariu A; BioViva USA, Inc., Bainbridge Island, WA 98110.
Cruz-Cosme R; Department of Microbiology, Howard University College of Medicine, Washington, DC 20059.
Tong M; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103.
Yang S; Department of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, Shenzhen Nanshan People's Hospital, The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518000, China.
Stefa A; Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103.; New Jersey Medical School, Cancer Institute of New Jersey-Newark, Rutgers Biomedical and Health Sciences, Newark, NJ 07103.
Kekich D; BioViva USA, Inc., Bainbridge Island, WA 98110.
Sadoshima J; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103.
Herbig U; Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103.; New Jersey Medical School, Cancer Institute of New Jersey-Newark, Rutgers Biomedical and Health Sciences, Newark, NJ 07103.
Tang Q; Department of Microbiology, Howard University College of Medicine, Washington, DC 20059.
Church G; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Parrish EL; BioViva USA, Inc., Bainbridge Island, WA 98110.
Zhu H; Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 May 17; Vol. 119 (20), pp. e2121499119. Date of Electronic Publication: 2022 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
Cytomegalovirus Infections*
Genetic Therapy*/adverse effects
Genetic Therapy*/methods
Life Expectancy*
Telomerase*/genetics
Telomerase*/metabolism
Administration, Inhalation ; Animals ; Follistatin/genetics ; Genetic Vectors/genetics ; Injections, Intraperitoneal ; Mice ; Models, Animal ; Neoplasms
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Gene Therapy for Neurological Disease: State of the Art and Opportunities for Next-generation Approaches.
Autorzy :
Morris G; Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
Schorge S; Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2022 May 10; Vol. 490, pp. 309-314. Date of Electronic Publication: 2022 Mar 16.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Therapy*
Parkinson Disease*/genetics
Humans
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Gene Therapy and the Use of Animal Models: Why Mice Alone Are Not Sufficient.
Autorzy :
Gruntman AM; Horae Gene Therapy Center and.; Department of Pediatrics, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA; and.; Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, Grafton, Massachusetts, USA.
Flotte TR; Horae Gene Therapy Center and.; Department of Pediatrics, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA; and.
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Źródło :
Human gene therapy [Hum Gene Ther] 2022 May; Vol. 33 (9-10), pp. 477-478.
Typ publikacji :
Wiadomości
MeSH Terms :
Genetic Therapy*
Animals ; Disease Models, Animal ; Mice
Periodyk
Szczegóły
Podgląd okładki
Tytuł :
Efficacy, safety and cost of gene therapy medicinal products in the U.S. and Europe.
Autorzy :
Balkhi B; Clinical Pharmacy Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. .
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Źródło :
Drugs of today (Barcelona, Spain : 1998) [Drugs Today (Barc)] 2022 May; Vol. 58 (5), pp. 223-240.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Therapy*/adverse effects
Europe ; Humans ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Convergence or divergence: next frontiers toward globalization of current- and next-generation cell and gene therapies.
Autorzy :
Bachtarzi H; Suite 2 Ground Floor Field House Station Approach, Harlow, Essex, CM20 2FB, UK.
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Źródło :
Regenerative medicine [Regen Med] 2022 May; Vol. 17 (5), pp. 313-326. Date of Electronic Publication: 2022 Mar 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Therapy*
Therapies, Investigational*
Humans ; Internationality ; Marketing ; Tissue Engineering
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Extension in the approaches to treat cancer through siRNA system: a beacon of hope in cancer therapy.
Autorzy :
Rautela I; Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal University, Dehradun, 248001, Uttarakhand, India.
Sharma A; Department of Biotechnology and Department of Life Sciences, Graphic Era Deemed to be University, Dehradun, 248002, Uttarakhand, India.
Dheer P; Department of Biotechnology, School of Basic and Applied Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, 248001, Uttarakhand, India.
Thapliyal P; Department of Biochemistry, H.N.B. Garhwal (A Central) University, Srinagar, 246174, Uttarakhand, India.
Sahni S; Department of Microbiology, School of Basic and Applied Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, 248001, Uttarakhand, India.
Sinha VB; Rani Lakshmi Bai Central Agricultural University, Jhansi, 284003, Uttar Pradesh, India.
Sharma MD; Department of Biotechnology, School of Basic and Applied Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, 248001, Uttarakhand, India. .
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Źródło :
Drug delivery and translational research [Drug Deliv Transl Res] 2022 May; Vol. 12 (5), pp. 1002-1016. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Therapy*
Neoplasms*/drug therapy
Neoplasms*/therapy
Drug Delivery Systems ; Humans ; RNA Interference ; RNA, Small Interfering/genetics
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Drug delivery systems for RNA therapeutics.
Autorzy :
Paunovska K; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA.
Loughrey D; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA.
Dahlman JE; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA. .
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Źródło :
Nature reviews. Genetics [Nat Rev Genet] 2022 May; Vol. 23 (5), pp. 265-280. Date of Electronic Publication: 2022 Jan 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Delivery Systems*
Genetic Therapy*
Genetic Vectors ; RNA, Small Interfering/genetics
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Vector engineering, strategies and targets in cancer gene therapy.
Autorzy :
Singh V; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, UP, India.
Khan N; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, UP, India.
Jayandharan GR; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, UP, India. .; The Mehta Family Centre for Engineering in Medicine, Indian Institute of Technology, Kanpur, UP, India. .
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Źródło :
Cancer gene therapy [Cancer Gene Ther] 2022 May; Vol. 29 (5), pp. 402-417. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Therapy*
Neoplasms*/genetics
Neoplasms*/therapy
Combined Modality Therapy ; Genes, Neoplasm ; Genetic Vectors/genetics ; Humans
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Impact of Time Out of Intended Storage and Freeze-thaw Rates on the Stability of Adeno-associated Virus 8 and 9.
Autorzy :
Bee JS; Formulation and Drug Product Development, REGENXBIO Inc., Rockville, MD 20850, USA. Electronic address: .
Zhang YZ; Formulation and Drug Product Development, REGENXBIO Inc., Rockville, MD 20850, USA.
Phillippi MK; Formulation and Drug Product Development, REGENXBIO Inc., Rockville, MD 20850, USA.
Finkner S; Formulation and Drug Product Development, REGENXBIO Inc., Rockville, MD 20850, USA.
Mezghebe T; Manufacturing Sciences, REGENXBIO Inc., Rockville, MD 20850, USA.
Webber K; Analytical Development, REGENXBIO Inc., Rockville, MD 20850, USA.
Cheung WD; Analytical Development, REGENXBIO Inc., Rockville, MD 20850, USA.
Marshall T; Process Development, REGENXBIO Inc., Rockville, MD 20850, USA.
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Źródło :
Journal of pharmaceutical sciences [J Pharm Sci] 2022 May; Vol. 111 (5), pp. 1346-1353. Date of Electronic Publication: 2022 Jan 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dependovirus*/genetics
Genetic Therapy*
DNA ; Freezing ; Genetic Vectors
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Lentiviral Mediated ADA2 Gene Transfer Corrects the Defects Associated With Deficiency of Adenosine Deaminase Type 2.
Autorzy :
Hong Y; Infection, Immunity, Inflammation Department, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Casimir M; Infection, Immunity, Inflammation Department, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Houghton BC; Infection, Immunity, Inflammation Department, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Zhang F; Infection, Immunity, Inflammation Department, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Jensen B; Infection, Immunity, Inflammation Department, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Omoyinmi E; Infection, Immunity, Inflammation Department, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Torrance R; Infection, Immunity, Inflammation Department, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Papadopoulou C; Infection, Immunity, Inflammation Department, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Cummins M; Paediatric Haematology, Bristol Royal Hospital for Children, Bristol, United Kingdom.
Roderick M; Paediatric Clinical Immunology, Bristol Royal Hospital for Children, Bristol, United Kingdom.
Thrasher AJ; Infection, Immunity, Inflammation Department, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Brogan PA; Infection, Immunity, Inflammation Department, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.
Eleftheriou D; Infection, Immunity, Inflammation Department, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.; Versus Arthritis Centre for Adolescent Rheumatology, University College London (UCL), London, United Kingdom.
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Źródło :
Frontiers in immunology [Front Immunol] 2022 Apr 22; Vol. 13, pp. 852830. Date of Electronic Publication: 2022 Apr 22 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Agammaglobulinemia*/therapy
Genetic Therapy*
Severe Combined Immunodeficiency*/therapy
Vasculitis*/therapy
Adenosine Deaminase/genetics ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Tumor Necrosis Factor Inhibitors
SCR Disease Name :
Severe combined immunodeficiency due to adenosine deaminase deficiency
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Telomerase gene therapy: a remission toward cancer.
Autorzy :
Quazi S; GenLab Biosolutions Private Limited, Bangalore, Karnataka, 560043, India. .; Department of Biomedical Sciences, School of Life Science, Anglia Ruskin University, Cambridge, UK. .
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Źródło :
Medical oncology (Northwood, London, England) [Med Oncol] 2022 Apr 16; Vol. 39 (6), pp. 105. Date of Electronic Publication: 2022 Apr 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Therapy*
Neoplasms*/therapy
Telomerase*
Animals ; Carcinogenesis ; Humans ; Telomere/genetics ; Telomere/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Of mice and men: From hematopoiesis in mouse models to curative gene therapy for sickle cell disease.
Autorzy :
Makani J; Department of Haematology and Blood transfusion, Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania; Sickle Pan African Research Consortium (SPARCO) Clinical Coordinating Centre, SickleInAfrica, Dar-es-Salaam, Tanzania. Electronic address: .
Luzzatto L; Department of Haematology and Blood transfusion, Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania; University of Florence, Firenze, Italy.
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Źródło :
Cell [Cell] 2022 Apr 14; Vol. 185 (8), pp. 1261-1265. Date of Electronic Publication: 2022 Apr 05.
Typ publikacji :
Journal Article
MeSH Terms :
Anemia, Sickle Cell*/genetics
Anemia, Sickle Cell*/therapy
Awards and Prizes*
Genetic Therapy*
Animals ; Disease Models, Animal ; Fetal Hemoglobin/genetics ; Hematopoiesis/genetics ; Humans ; Mice ; Repressor Proteins/genetics
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice.
Autorzy :
Wang J; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Zhang Y; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Mendonca CA; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Yukselen O; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Bioinformatics Core, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Muneeruddin K; Mass Spectrometry Facility, University of Massachusetts Chan Medical School, Shrewsbury, MA, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Chan Medical School, Shrewsbury, MA, USA.
Ren L; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Liang J; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Zhou C; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Xie J; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Li J; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jiang Z; Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Kucukural A; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Bioinformatics Core, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Shaffer SA; Mass Spectrometry Facility, University of Massachusetts Chan Medical School, Shrewsbury, MA, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Chan Medical School, Shrewsbury, MA, USA.
Gao G; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA. .; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA, USA. .
Wang D; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA. .; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA. .
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Źródło :
Nature [Nature] 2022 Apr; Vol. 604 (7905), pp. 343-348. Date of Electronic Publication: 2022 Mar 23.
Typ publikacji :
Journal Article
MeSH Terms :
Codon, Nonsense*/genetics
Dependovirus*/genetics
Genetic Therapy*
Adenoviridae ; Animals ; Codon, Terminator/genetics ; Codon, Terminator/metabolism ; Genetic Diseases, Inborn/therapy ; Genetic Vectors ; Humans ; Mice ; Nonsense Mediated mRNA Decay/genetics ; RNA, Transfer/genetics ; RNA, Transfer/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Revisiting the role of pulsed electric fields in overcoming the barriers to in vivo gene electrotransfer.
Autorzy :
Sachdev S; University of Ljubljana, Faculty of Electrical Engineering, Tržaška cesta 25, 1000 Ljubljana, Slovenia.
Potočnik T; University of Ljubljana, Faculty of Electrical Engineering, Tržaška cesta 25, 1000 Ljubljana, Slovenia.
Rems L; University of Ljubljana, Faculty of Electrical Engineering, Tržaška cesta 25, 1000 Ljubljana, Slovenia.
Miklavčič D; University of Ljubljana, Faculty of Electrical Engineering, Tržaška cesta 25, 1000 Ljubljana, Slovenia. Electronic address: .
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Źródło :
Bioelectrochemistry (Amsterdam, Netherlands) [Bioelectrochemistry] 2022 Apr; Vol. 144, pp. 107994. Date of Electronic Publication: 2021 Nov 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Electroporation*/instrumentation
Electroporation*/methods
Gene Transfer Techniques*/instrumentation
Genetic Therapy*/methods
Animals ; COVID-19/prevention & control ; Equipment Design ; Humans ; Vaccines, DNA/administration & dosage ; Vaccines, DNA/genetics ; Vaccines, DNA/therapeutic use ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/therapeutic use ; mRNA Vaccines/administration & dosage ; mRNA Vaccines/genetics ; mRNA Vaccines/therapeutic use
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
A Boost for Muscle with Gene Therapy.
Autorzy :
Chamberlain JS; From the Department of Neurology, University of Washington School of Medicine, Seattle.
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Źródło :
The New England journal of medicine [N Engl J Med] 2022 Mar 24; Vol. 386 (12), pp. 1184-1186.
Typ publikacji :
Journal Article
MeSH Terms :
Dependovirus*
Genetic Therapy*
Genetic Vectors*
Muscular Dystrophy, Duchenne/*therapy
Animals ; Disease Models, Animal ; Humans ; Infusions, Intravenous ; Mice ; Muscle, Skeletal
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Synthetic Conjugated Oligoelectrolytes Are Effective siRNA Transfection Carriers: Relevance to Pancreatic Cancer Gene Therapy.
Autorzy :
Yang C; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Huang H; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Singh NM; School of Electrical and Electronic Engineering, Nanyang Technological University, 639798 Singapore.
Zhou C; Departments of Chemistry and Chemical Engineering, National University of Singapore, 119077 Singapore.
Yang G; School of Electrical and Electronic Engineering, Nanyang Technological University, 639798 Singapore.
Xu Z; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Lin H; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Xu G; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Yong KT; School of Biomedical Engineering, The University of Sydney, Sydney, New South Wales 2006, Australia.; The University of Sydney Nano Institute, The University of Sydney, Sydney, New South Wales 2006, Australia.
Bazan GC; Departments of Chemistry and Chemical Engineering, National University of Singapore, 119077 Singapore.
Pokaż więcej
Źródło :
Biomacromolecules [Biomacromolecules] 2022 Mar 14; Vol. 23 (3), pp. 1259-1268. Date of Electronic Publication: 2022 Feb 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Therapy*
Pancreatic Neoplasms*/genetics
Pancreatic Neoplasms*/therapy
Cell Line, Tumor ; Humans ; RNA, Small Interfering/chemistry ; Transfection
SCR Disease Name :
Pancreatic Carcinoma
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 54540

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