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Wyszukujesz frazę ""Genomic Instability"" wg kryterium: Temat


Tytuł :
HNRNPL Is Identified and Validated as a Prognostic Biomarker Associated with Microsatellite Instability in Human Gastric Cancer.
Autorzy :
Yu X; Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Cao F; Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Yu Y; Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Li Y; Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Zhang J; Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Xu T; Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Di Q; Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Wu G; Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Zhang Z; Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Wang R; Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Li Y; Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2021 Oct; Vol. 40 (10), pp. 1251-1260. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Genomic Instability*
Microsatellite Repeats*
Biomarkers, Tumor/*genetics
Ribonucleoproteins/*genetics
Stomach Neoplasms/*genetics
Aged ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Male ; Middle Aged ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; Ribonucleoproteins/metabolism ; Stomach Neoplasms/pathology ; Up-Regulation
Czasopismo naukowe
Tytuł :
Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders.
Autorzy :
Jia N; Department of Allergy and Clinical Immunology, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Guo C; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Nakazawa Y; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
van den Heuvel D; Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Luijsterburg MS; Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands. Electronic address: .
Ogi T; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Graduate School of Medicine, Nagoya University, Nagoya, Japan. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Oct; Vol. 106, pp. 103192. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Damage*
DNA Repair*
Genomic Instability*
Transcription, Genetic*
RNA Polymerase II/*metabolism
Aging ; Animals ; DNA/metabolism ; Eukaryota/enzymology ; Eukaryota/genetics ; Eukaryota/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Genome maintenance during embryogenesis.
Autorzy :
Munisha M; Dept. of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, United States.
Schimenti JC; Dept. of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, United States. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Oct; Vol. 106, pp. 103195. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
DNA Repair*
Genomic Instability*
Mutation*
Embryonic Development/*genetics
Animals ; Cell Proliferation ; DNA/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Defining R-loop classes and their contributions to genome instability.
Autorzy :
Castillo-Guzman D; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA, 95616, United States.
Chédin F; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA, 95616, United States. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Oct; Vol. 106, pp. 103182. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Genomic Instability*
R-Loop Structures*
Transcription, Genetic*
Animals ; Eukaryota/genetics ; Eukaryota/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Elevated somatic mutation and evidence of genomic instability in veterans with Gulf War illness.
Autorzy :
Grant SG; Department of Public Health, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, United States of America; AutoNation Institute for Breast Cancer Research, Fort Lauderdale, FL, United States of America. Electronic address: .
Ibrahim OM; AutoNation Institute for Breast Cancer Research, Fort Lauderdale, FL, United States of America; Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, United States of America.
Jin XL; Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, United States of America.
Klimas NG; Department of Clinical Immunology, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, United States of America; Department of Medicine, Miami VA Healthcare System, Miami, FL, United States of America.
Sullivan K; Department of Environmental Health, Boston University School of Public Health, Boston, MA, United States of America.
Latimer JJ; AutoNation Institute for Breast Cancer Research, Fort Lauderdale, FL, United States of America; Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, United States of America.
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Źródło :
Life sciences [Life Sci] 2021 Sep 15; Vol. 281, pp. 119746. Date of Electronic Publication: 2021 Jun 26.
Typ publikacji :
Journal Article
MeSH Terms :
Genomic Instability*
Mutation*
Veterans*
Persian Gulf Syndrome/*genetics
Case-Control Studies ; Glycophorins/genetics ; Humans ; Male
Czasopismo naukowe
Tytuł :
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.
Autorzy :
Bloehdorn J; Department of Internal Medicine III, University of Ulm, Ulm, Germany. .
Braun A; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Taylor-Weiner A; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Jebaraj BMC; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Robrecht S; Department I for Internal Medicine and Centre for Integrated Oncology, University of Cologne, Cologne, Germany.
Krzykalla J; Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany.
Pan H; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Giza A; Department I for Internal Medicine and Centre for Integrated Oncology, University of Cologne, Cologne, Germany.
Akylzhanova G; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Holzmann K; Genomics Core Facility, Ulm University, Ulm, Germany.
Scheffold A; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Johnston HE; Centre for Cancer Immunology, Cancer Sciences, Faculty of Medicine, Cancer Research UK Centre and Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK.
Yeh RF; Biostatistics, Genentech Inc., South San Francisco, CA, USA.
Klymenko T; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Tausch E; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Eichhorst B; Department I for Internal Medicine and Centre for Integrated Oncology, University of Cologne, Cologne, Germany.
Bullinger L; Medical Clinic for Hematology, Oncology and Tumor Biology, Charité University Hospital, Berlin, Germany.
Fischer K; Department I for Internal Medicine and Centre for Integrated Oncology, University of Cologne, Cologne, Germany.
Weisser M; Roche Pharma Research and Early Development, Penzberg, Germany.
Robak T; Department of Hematology, Medical University of Lodz, Lodz, Poland.
Schneider C; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Gribben J; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Dahal LN; Centre for Cancer Immunology, Cancer Sciences, Faculty of Medicine, Cancer Research UK Centre and Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK.; Department of Pharmacology and Therapeutics, Faculty of Life and Health Sciences, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Carter MJ; Centre for Cancer Immunology, Cancer Sciences, Faculty of Medicine, Cancer Research UK Centre and Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK.
Elemento O; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Landau DA; Cancer Genomics and Evolutionary Dynamics, Weill Cornell Medicine, New York, NY, USA.; New York Genome Center, New York, NY, USA.
Neuberg DS; Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Cragg MS; Centre for Cancer Immunology, Cancer Sciences, Faculty of Medicine, Cancer Research UK Centre and Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK.
Benner A; Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany.
Hallek M; Department I for Internal Medicine and Centre for Integrated Oncology, University of Cologne, Cologne, Germany.
Wu CJ; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Döhner H; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Stilgenbauer S; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Mertens D; Department of Internal Medicine III, University of Ulm, Ulm, Germany. .; German Cancer Research Center (DKFZ), Heidelberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 13; Vol. 12 (1), pp. 5395. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Leukemic*
Gene Regulatory Networks*
Genomic Instability*
Epithelial-Mesenchymal Transition/*genetics
Gene Expression Profiling/*methods
Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
Ataxia Telangiectasia Mutated Proteins/genetics ; Chromosome Aberrations ; DNA Damage ; DNA Repair ; Humans ; Mutation ; Polymorphism, Single Nucleotide ; Telomere-Binding Proteins/genetics ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Genome instability and success of checkpoint inhibitors: form and levels matter.
Autorzy :
Derks S; Amsterdam UMC, Location VUmc, Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam, The Netherlands; Oncode Institute, Utrecht, The Netherlands. Electronic address: .
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Źródło :
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2021 Sep; Vol. 32 (9), pp. 1073-1074. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Genomic Instability*
Microsatellite Instability*
Humans
Raport
Tytuł :
Rapid Production and Genetic Stability of Human Mesenchymal Progenitor Cells Derived from Human Somatic Cell Nuclear Transfer-Derived Pluripotent Stem Cells.
Autorzy :
Jung SK; CHA Advanced Research Institute, CHA University Bundang Medical Center, Seongnam 13488, Gyeonggi, Korea.
Lee JE; CHA Advanced Research Institute, CHA University Bundang Medical Center, Seongnam 13488, Gyeonggi, Korea.
Lee CW; CHA Advanced Research Institute, CHA University Bundang Medical Center, Seongnam 13488, Gyeonggi, Korea.
Shim SH; Department of Biomedical Science, CHA University, Seongnam 13488, Gyeonggi, Korea.
Lee DR; CHA Advanced Research Institute, CHA University Bundang Medical Center, Seongnam 13488, Gyeonggi, Korea.; Department of Biomedical Science, CHA University, Seongnam 13488, Gyeonggi, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 26; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
Genomic Instability*
Induced Pluripotent Stem Cells/*metabolism
Mesenchymal Stem Cells/*metabolism
Nuclear Transfer Techniques/*standards
Cell Differentiation ; Cell Line ; Cells, Cultured ; Humans ; Induced Pluripotent Stem Cells/cytology ; Mesenchymal Stem Cells/cytology ; Polymorphism, Genetic
Czasopismo naukowe
Tytuł :
A guanidine-degrading enzyme controls genomic stability of ethylene-producing cyanobacteria.
Autorzy :
Wang B; Biosciences Center, National Renewable Energy Laboratory, Golden, CO, USA. .; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. .
Xu Y; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Wang X; Synthetic and Systems Biology Innovation Hub, Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, USA.; Department of Microbiology, Miami University, Oxford, OH, USA.
Yuan JS; Synthetic and Systems Biology Innovation Hub, Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, USA.
Johnson CH; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Young JD; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Yu J; Biosciences Center, National Renewable Energy Laboratory, Golden, CO, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 26; Vol. 12 (1), pp. 5150. Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genomic Instability*
Bacterial Proteins/*metabolism
Ethylenes/*biosynthesis
Guanidine/*metabolism
Synechococcus/*genetics
Synechococcus/*metabolism
Synechocystis/*enzymology
Bacterial Proteins/genetics ; Gene Expression Regulation, Bacterial ; Genome, Bacterial ; Synechocystis/genetics
SCR Organism :
Synechococcus elongatus
Czasopismo naukowe
Tytuł :
R-Loops and Its Chro-Mates: The Strange Case of Dr. Jekyll and Mr. Hyde.
Autorzy :
Uruci S; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Lo CSY; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Wheeler D; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Taneja N; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 17; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Chromatin Assembly and Disassembly*
DNA Damage*
DNA Repair*
DNA Replication*
Genomic Instability*
R-Loop Structures*
Humans
Czasopismo naukowe
Tytuł :
The SCF Complex Is Essential to Maintain Genome and Chromosome Stability.
Autorzy :
Thompson LL; CancerCare Manitoba Research Institute, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada.; Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Rutherford KA; CancerCare Manitoba Research Institute, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada.; Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Lepage CC; CancerCare Manitoba Research Institute, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada.; Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
McManus KJ; CancerCare Manitoba Research Institute, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada.; Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 09; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Chromosomes, Human*/genetics
Chromosomes, Human*/metabolism
Genomic Instability*
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Neoplasms*/genetics
Neoplasms*/metabolism
SKP Cullin F-Box Protein Ligases*/genetics
SKP Cullin F-Box Protein Ligases*/metabolism
Transcription, Genetic*
Animals ; Humans
Czasopismo naukowe
Tytuł :
Mutagen-induced telomere instability in human cells.
Autorzy :
Bolzán AD; Laboratorio de Citogenética y Mutagénesis, Instituto Multidisciplinario de Biología Celular (IMBICE, CONICET-CICPBA-UNLP), calle 526 y Camino General Belgrano, B1906APO La Plata, Buenos Aires, Argentina; Universidad Nacional de La Plata, Facultad de Ciencias Naturales y Museo, calle 60 y 122, La Plata, Buenos Aires, Argentina. Electronic address: .
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Źródło :
Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2021 Aug-Sep; Vol. 868-869, pp. 503387. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Chromosomal Instability/*drug effects
Genomic Instability/*drug effects
Mutagens/*toxicity
Telomere/*drug effects
Animals ; Cellular Senescence/drug effects ; Cellular Senescence/genetics ; Chromosomal Instability/genetics ; DNA/genetics ; DNA Breaks, Double-Stranded/drug effects ; Genomic Instability/genetics ; Humans ; Telomere/genetics
Czasopismo naukowe
Tytuł :
Identification and validation of a novel eight mutant-derived long non-coding RNAs signature as a prognostic biomarker for genome instability in low-grade glioma.
Autorzy :
Maimaiti A; Department of Functional Neurosurgery, Neurosurgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Wang X; Department of Functional Neurosurgery, Neurosurgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Pei Y; Department of Functional Neurosurgery, Neurosurgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Nuermaimaiti N; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Disease in Central Asia, Department of Biochemistry and Molecular Biology, Basic Medicine College, Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Tuersunniyazi A; Department of Functional Neurosurgery, Neurosurgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Abula Y; Department of Functional Neurosurgery, Neurosurgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Feng Z; Department of Functional Neurosurgery, Neurosurgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Jiang L; Department of Functional Neurosurgery, Neurosurgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Shi X; Department of Functional Neurosurgery, Neurosurgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Kasimu M; Department of Functional Neurosurgery, Neurosurgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
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Źródło :
Aging [Aging (Albany NY)] 2021 Jun 03; Vol. 13 (11), pp. 15164-15192. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article; Validation Study
MeSH Terms :
Gene Expression Profiling*
Genomic Instability*
Biomarkers, Tumor/*genetics
Brain Neoplasms/*genetics
Brain Neoplasms/*pathology
Glioma/*genetics
Glioma/*pathology
RNA, Long Noncoding/*genetics
Adult ; Area Under Curve ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Isocitrate Dehydrogenase/genetics ; Kaplan-Meier Estimate ; Male ; Multivariate Analysis ; Mutation/genetics ; Neoplasm Grading ; Prognosis ; Proportional Hazards Models ; RNA, Long Noncoding/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; ROC Curve ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Integrin-Linked-Kinase Overexpression Is Implicated in Mechanisms of Genomic Instability in Human Colorectal Cancer.
Autorzy :
Chadla P; Department of Anatomy, Histology and Embryology, Medical School, University of Patras, Rio, 26500, Greece.
Arbi M; Department of Biology, Medical School, University of Patras, Rio, Greece.
Nikou S; Department of Anatomy, Histology and Embryology, Medical School, University of Patras, Rio, 26500, Greece.
Kalliakoudas T; Department of Physiology, Medical School, University of Patras, Rio, Greece.
Papadaki H; Department of Anatomy, Histology and Embryology, Medical School, University of Patras, Rio, 26500, Greece.
Taraviras S; Department of Physiology, Medical School, University of Patras, Rio, Greece.
Lygerou Z; Department of Biology, Medical School, University of Patras, Rio, Greece.
Bravou V; Department of Anatomy, Histology and Embryology, Medical School, University of Patras, Rio, 26500, Greece. .
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Źródło :
Digestive diseases and sciences [Dig Dis Sci] 2021 May; Vol. 66 (5), pp. 1510-1523. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Genomic Instability*
Micronuclei, Chromosome-Defective*
Colorectal Neoplasms/*enzymology
Protein-Serine-Threonine Kinases/*metabolism
Ataxia Telangiectasia Mutated Proteins/metabolism ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; HCT116 Cells ; Histones/metabolism ; Humans ; Phosphorylation ; Protein-Serine-Threonine Kinases/genetics ; Signal Transduction ; Spindle Apparatus/enzymology ; Spindle Apparatus/genetics ; Spindle Apparatus/pathology
Czasopismo naukowe
Tytuł :
Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis.
Autorzy :
Jin X; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Qing S; State Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Li Q; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Zhuang H; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Shen L; Department of Urology, Department of Hematology, the Affiliated Yinzhou Renmin Hospital of Medical School of Ningbo University, Ningbo 315040, China.
Li J; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.
Qi H; Department of Urology, the Affiliated Yinzhou Second Hospital of Medical School of Ningbo University, Ningbo 315100, China.
Lin T; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Lin Z; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Wang J; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Cao X; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Yang J; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Ma Q; Translational Research Laboratory for Urology, the Key Laboratory of Ningbo City. Ningbo First Hospital, The affiliated hospital of Ningbo University, Ningbo, Zhejiang 315010, China.
Cong L; Department of Urology, Department of Hematology, the Affiliated Yinzhou Renmin Hospital of Medical School of Ningbo University, Ningbo 315040, China.
Xi Y; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Fang S; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Meng X; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Gong Z; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Ye M; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Wang S; Department of Breast Surgery, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
Wang C; State Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Gao K; Department of Clinical Laboratory, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 09; Vol. 49 (12), pp. 6788-6803.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genomic Instability*
Carrier Proteins/*metabolism
Nuclear Proteins/*genetics
Nuclear Proteins/*metabolism
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Repressor Proteins/*genetics
Repressor Proteins/*metabolism
Ataxia Telangiectasia Mutated Proteins/metabolism ; Carrier Proteins/chemistry ; Cell Line, Tumor ; Chromosomal Proteins, Non-Histone/metabolism ; DNA Damage ; Histones/metabolism ; Humans ; Male ; Mutation ; Phosphorylation ; Prostatic Neoplasms/enzymology ; Prostatic Neoplasms/pathology ; Protein-Serine-Threonine Kinases/chemistry ; Serine/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
Replication initiation: Implications in genome integrity.
Autorzy :
Lin YC; Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, 601S Goodwin Avenue, Urbana, IL, 61801, USA. Electronic address: .
Prasanth SG; Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, 601S Goodwin Avenue, Urbana, IL, 61801, USA. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Jul; Vol. 103, pp. 103131. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Replication*
Genomic Instability*
Animals ; Cell Cycle ; Eukaryota/genetics ; Humans ; Replication Origin
Czasopismo naukowe
Tytuł :
NORAD-induced Pumilio phase separation is required for genome stability.
Autorzy :
Elguindy MM; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mendell JT; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA. .; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. .; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. .; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
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Źródło :
Nature [Nature] 2021 Jul; Vol. 595 (7866), pp. 303-308. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genomic Instability*
Phase Transition*
RNA, Long Noncoding/*genetics
RNA, Long Noncoding/*metabolism
RNA-Binding Proteins/*chemistry
RNA-Binding Proteins/*metabolism
Transcription Factors/*chemistry
Transcription Factors/*metabolism
Cell Line ; Cytoplasm/chemistry ; Cytoplasm/genetics ; Cytoplasm/metabolism ; Humans ; RNA/chemistry ; RNA/genetics ; RNA/metabolism ; RNA, Long Noncoding/chemistry
Czasopismo naukowe
Tytuł :
Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons.
Autorzy :
Lou MM; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Beijing, China.
Tang XQ; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Beijing, China.
Wang GM; East Hospital, Tongji University School of Medicine, Shanghai, China.; Department of Hematology, Tongji Hospital of Tongji University School of Medicine, Shanghai, China.; Postdoctoral Station of Clinical Medicine, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
He J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Beijing, China.
Luo F; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.
Guan MF; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Beijing, China.
Wang F; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Beijing, China.
Zou H; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Beijing, China.
Wang JY; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhang Q; Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Xu MJ; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.
Shi QL; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.
Shen LB; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.
Ma GM; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Beijing, China.
Wu Y; Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Zhang YY; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China.
Liang AB; Postdoctoral Station of Clinical Medicine, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Wang TH; Animal Center of Zoology, Institute of Neuroscience, Kunming medical University, Kunming, China.
Xiong LL; Animal Center of Zoology, Institute of Neuroscience, Kunming medical University, Kunming, China.
Wang J; Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Jing'an District, Shanghai, China. .
Xu J; East Hospital, Tongji University School of Medicine, Shanghai, China. .
Wang WY; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science, Shanghai, 200032, China. .; Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China. .; Animal Center of Zoology, Institute of Neuroscience, Kunming medical University, Kunming, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 01; Vol. 12 (1), pp. 4075. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Genomic Instability*
Alcohol Oxidoreductases/*metabolism
HMGB1 Protein/*metabolism
Neurons/*metabolism
RNA, Long Noncoding/*metabolism
Alcohol Oxidoreductases/genetics ; Animals ; Biological Phenomena ; Cerebellum ; Chromatin ; Female ; Gene Expression Regulation ; HMGB1 Protein/genetics ; Male ; Mice ; Mice, Knockout ; Mutation ; RNA, Long Noncoding/genetics
Czasopismo naukowe
Tytuł :
New insights into the functional role of retrotransposon dynamics in mammalian somatic cells.
Autorzy :
Mangiavacchi A; Biological Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Liu P; Biological Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Della Valle F; Biological Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Orlando V; Biological Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jul; Vol. 78 (13), pp. 5245-5256. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Epigenome*
Evolution, Molecular*
Genomic Instability*
Retroelements*
Mammals/*genetics
RNA, Untranslated/*genetics
Animals ; Humans ; Mammals/growth & development
Czasopismo naukowe
Tytuł :
Autism-Associated Vigilin Depletion Impairs DNA Damage Repair.
Autorzy :
Banday S; Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India.
Pandita RK; Houston Methodist Research Institute, Houston, Texas, USA.; Baylor College of Medicine, Houston, Texas, USA.
Mushtaq A; Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India.
Bacolla A; Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Mir US; Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India.
Singh DK; Houston Methodist Research Institute, Houston, Texas, USA.
Jan S; Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India.
Bhat KP; Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Hunt CR; Houston Methodist Research Institute, Houston, Texas, USA.
Rao G; Baylor College of Medicine, Houston, Texas, USA.
Charaka VK; Houston Methodist Research Institute, Houston, Texas, USA.
Tainer JA; Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.; Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Pandita TK; Houston Methodist Research Institute, Houston, Texas, USA.; Baylor College of Medicine, Houston, Texas, USA.
Altaf M; Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India.; Centre for Interdisciplinary Research and Innovations, University of Kashmir, Srinagar, Jammu and Kashmir, India.
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2021 Jun 23; Vol. 41 (7), pp. e0008221. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Breaks, Double-Stranded*
Autistic Disorder/*metabolism
DNA Repair/*genetics
Genomic Instability/*physiology
BRCA1 Protein ; DNA Repair/physiology ; DNA Replication/genetics ; Genomic Instability/genetics ; Humans ; RNA-Binding Proteins/metabolism ; Rad51 Recombinase/genetics
Czasopismo naukowe

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