Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells.
Autorzy:
Hong SK; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Starenki D; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Johnson OT; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA. GestwickiJE; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA. Park JI; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.
Autorzy:
Chen X; Gladstone Institute of Neurological Disease, University of California, San Francisco, CA, 94158, USA. .; Department of Neurology, University of California, San Francisco, CA, 94158, USA. . Li Y; Gladstone Institute of Neurological Disease, University of California, San Francisco, CA, 94158, USA. Wang C; Gladstone Institute of Neurological Disease, University of California, San Francisco, CA, 94158, USA.; Department of Neurology, University of California, San Francisco, CA, 94158, USA. Tang Y; Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158, USA. Mok SA; Institute for Neurodegenerative Disease, Department of Pharmaceutical Chemistry, Weill Institute for Neurosciences, University of California, San Francisco, CA, 94158, USA. Tsai RM; Department of Neurology, University of California, San Francisco, CA, 94158, USA.; Memory and Aging Center, University of California, San Francisco, CA, 94158, USA. Rojas JC; Department of Neurology, University of California, San Francisco, CA, 94158, USA.; Memory and Aging Center, University of California, San Francisco, CA, 94158, USA. Karydas A; Department of Neurology, University of California, San Francisco, CA, 94158, USA.; Memory and Aging Center, University of California, San Francisco, CA, 94158, USA. Miller BL; Department of Neurology, University of California, San Francisco, CA, 94158, USA.; Memory and Aging Center, University of California, San Francisco, CA, 94158, USA. Boxer AL; Department of Neurology, University of California, San Francisco, CA, 94158, USA.; Memory and Aging Center, University of California, San Francisco, CA, 94158, USA. GestwickiJE; Institute for Neurodegenerative Disease, Department of Pharmaceutical Chemistry, Weill Institute for Neurosciences, University of California, San Francisco, CA, 94158, USA. Arkin M; Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158, USA. Cuervo AM; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. Gan L; Gladstone Institute of Neurological Disease, University of California, San Francisco, CA, 94158, USA. .; Department of Neurology, University of California, San Francisco, CA, 94158, USA. .; Helen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10065, USA. .
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2020 Jan 06; Vol. 15 (1), pp. 2. Date of Electronic Publication: 2020 Jan 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Predicting protein targets for drug-like compounds using transcriptomics.
Autorzy:
Pabon NA; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. Xia Y; Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America. Estabrooks SK; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. Ye Z; School of Medicine, Tsinghua University, Beijing, China. Herbrand AK; Department of Internal Medicine I, Universitätsklinikum Frankfurt, Frankfurt, Germany. Süß E; Department of Internal Medicine I, Universitätsklinikum Frankfurt, Frankfurt, Germany. Biondi RM; Department of Internal Medicine I, Universitätsklinikum Frankfurt, Frankfurt, Germany. Assimon VA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America. GestwickiJE; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America. Brodsky JL; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. Camacho CJ; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. Bar-Joseph Z; Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2018 Dec 07; Vol. 14 (12), pp. e1006651. Date of Electronic Publication: 2018 Dec 07 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Pharmacological chaperone for α-crystallin partially restores transparency in cataract models.
Autorzy:
Makley LN; Departments of Pathology, Biological Chemistry, and Medicinal Chemistry and the Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. McMenimen KA; Departments of Pathology, Biological Chemistry, and Medicinal Chemistry and the Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. DeVree BT; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA. Goldman JW; Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA. McGlasson BN; Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA. Rajagopal P; Department of Biochemistry, University of Washington, Seattle, WA, USA. Dunyak BM; Departments of Pathology, Biological Chemistry, and Medicinal Chemistry and the Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. McQuade TJ; Center for Chemical Genomics, University of Michigan, Ann Arbor, MI, USA. Thompson AD; Departments of Pathology, Biological Chemistry, and Medicinal Chemistry and the Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. Sunahara R; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA. Klevit RE; Department of Biochemistry, University of Washington, Seattle, WA, USA. Andley UP; Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA. . GestwickiJE; Departments of Pathology, Biological Chemistry, and Medicinal Chemistry and the Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. Center for Chemical Genomics, University of Michigan, Ann Arbor, MI, USA. .
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