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    Wyświetlanie 1-20 z 20
    Tytuł:
    Identification of Mycobacterium tuberculosis BioA inhibitors by using structure-based virtual screening
    Autorzy:
    Singh S
    Khare G
    Bahal RK
    Ghosh PC
    Tyagi AK
    Pokaż więcej
    Temat:
    Mycobacterium tuberculosis
    BioA
    virtual screening
    drug discovery
    Therapeutics. Pharmacology
    RM1-950
    Źródło:
    Drug Design, Development and Therapy, Vol Volume 12, Pp 1065-1079 (2018)
    Opis pliku:
    electronic resource
    Relacje:
    https://www.dovepress.com/identification-of-mycobacterium-tuberculosis-bioa-inhibitors-by-using--peer-reviewed-article-DDDT; https://doaj.org/toc/1177-8881
    Dostęp URL:
    https://doaj.org/article/8fd95a7168234079afd9db5960dffde9  Link otwiera się w nowym oknie
    Czasopismo naukowe
    Szczegóły
    Tytuł:
    Author Correction: Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model.
    Autorzy:
    Kumar P; Bio-Organic Research Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007, India. .
    Achieng AO; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.; Department of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno, Kenya.
    Rajendran V; Department of Biochemistry, University of Delhi South Campus, New Delhi, 110021, India.
    Ghosh PC; Department of Biochemistry, University of Delhi South Campus, New Delhi, 110021, India.
    Singh BK; Bio-Organic Research Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007, India.
    Rawat M; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
    Perkins DJ; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
    Kempaiah P; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
    Rathi B; Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi, 110007, India. .; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA-02139, United States of America. .
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    Źródło:
    Scientific reports [Sci Rep] 2020 Aug 24; Vol. 10 (1), pp. 14146. Date of Electronic Publication: 2020 Aug 24.
    Typ publikacji:
    Published Erratum
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Improved efficacy of doxycycline in liposomes against Plasmodium falciparum in culture and Plasmodium berghei infection in mice.
    Autorzy:
    Rajendran V; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India.; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India.
    Singh C; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India.; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India.
    Ghosh PC; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India.; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India.
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    Źródło:
    Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2018 Nov; Vol. 96 (11), pp. 1145-1152. Date of Electronic Publication: 2018 Aug 03.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antimalarials/*administration & dosage
    Doxycycline/*administration & dosage
    Drug Carriers/*chemistry
    Malaria/*drug therapy
    Plasmodium berghei/*pathogenicity
    Plasmodium falciparum/*drug effects
    Animals ; Antimalarials/therapeutic use ; Chloroquine/administration & dosage ; Chloroquine/therapeutic use ; Disease Models, Animal ; Doxycycline/therapeutic use ; Drug Resistance ; Erythrocytes/drug effects ; Erythrocytes/parasitology ; Female ; Humans ; Inhibitory Concentration 50 ; Liposomes ; Malaria/parasitology ; Malaria/pathology ; Mice ; Phosphatidylethanolamines/chemistry ; Plasmodium berghei/drug effects ; Polyethylene Glycols/chemistry ; Treatment Outcome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Synthesis and Evaluation of Antiplasmodial Activity of 2,2,2-Trifluoroethoxychalcones and 2-Fluoroethoxy Chalcones against Plasmodium falciparum in Culture.
    Autorzy:
    Devi K; Fluoroorganic Laboratory, Center for Fire, Explosive and Environment Safety, Delhi-110 054, India. .
    Rajendran V; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110 021, India. .
    Rangarajan TM; Department of Chemistry, Sri Venkateswara College, University of Delhi, New Delhi 110 021, India. .
    Singh RP; Department of Chemistry, Sri Venkateswara College, University of Delhi, New Delhi 110 021, India. .
    Ghosh PC; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110 021, India. .
    Singh M; Department of Chemistry, Shivaji College, University of Delhi, New Delhi 110 027, India. .
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    Corporate Authors:
    Ayushee; Department of Chemistry, Hansraj College, University of Delhi, Delhi 110 007, India. .
    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2018 May 14; Vol. 23 (5). Date of Electronic Publication: 2018 May 14.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antimalarials/*chemical synthesis
    Antimalarials/*pharmacology
    Chalcones/*chemical synthesis
    Chalcones/*pharmacology
    Plasmodium falciparum/*drug effects
    Animals ; Antimalarials/chemistry ; Chalcones/chemistry ; Chemistry Techniques, Synthetic ; Chlorocebus aethiops ; Erythrocytes/drug effects ; Erythrocytes/parasitology ; Inhibitory Concentration 50 ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Parasitic Sensitivity Tests ; Vero Cells
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model.
    Autorzy:
    Kumar P; Bio-Organic Research Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007, India.
    Achieng AO; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, United States of America.; Department of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno, Kenya.
    Rajendran V; Department of Biochemistry, University of Delhi South Campus, New Delhi, 110021, India.
    Ghosh PC; Department of Biochemistry, University of Delhi South Campus, New Delhi, 110021, India.
    Singh BK; Bio-Organic Research Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007, India.
    Rawat M; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, United States of America.
    Perkins DJ; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, United States of America.
    Kempaiah P; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, United States of America. .
    Rathi B; Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi, 110007, India. .; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA-02139, United States of America. .
    Pokaż więcej
    Źródło:
    Scientific reports [Sci Rep] 2017 Jul 27; Vol. 7 (1), pp. 6724. Date of Electronic Publication: 2017 Jul 27.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antimalarials/*pharmacology
    Life Cycle Stages/*drug effects
    Malaria/*drug therapy
    Phthalimides/*pharmacology
    Plasmodium berghei/*drug effects
    Plasmodium falciparum/*drug effects
    Animals ; Antimalarials/chemical synthesis ; Artemisinins/pharmacology ; Chloroquine/pharmacology ; Disease Models, Animal ; Drug Synergism ; Drug Therapy, Combination ; Erythrocytes/drug effects ; Erythrocytes/parasitology ; Female ; Humans ; Inhibitory Concentration 50 ; Life Cycle Stages/physiology ; Malaria/parasitology ; Mice ; Phthalimides/chemical synthesis ; Plasmodium berghei/growth & development ; Plasmodium falciparum/growth & development
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Hydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial Evaluation.
    Autorzy:
    Singh AK; Bioorganic Research Laboratory, Department of Chemistry, University of Delhi, Delhi, India.
    Rathore S; Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.
    Tang Y; Department of Biochemistry & Molecular Biology, University of Florida College of Medicine, P.O. Box 100245, Gainesville, FL, United States of America.
    Goldfarb NE; Department of Biochemistry & Molecular Biology, University of Florida College of Medicine, P.O. Box 100245, Gainesville, FL, United States of America.
    Dunn BM; Department of Biochemistry & Molecular Biology, University of Florida College of Medicine, P.O. Box 100245, Gainesville, FL, United States of America.
    Rajendran V; Department of Biochemistry, University of Delhi South Campus, Dhaula Kuan, New Delhi, India.
    Ghosh PC; Department of Biochemistry, University of Delhi South Campus, Dhaula Kuan, New Delhi, India.
    Singh N; Bioinformatics Center, Sri Venkateswara College, University of Delhi South Campus, Dhaula Kuan, New Delhi, India.
    Latha N; Bioinformatics Center, Sri Venkateswara College, University of Delhi South Campus, Dhaula Kuan, New Delhi, India.
    Singh BK; Bioorganic Research Laboratory, Department of Chemistry, University of Delhi, Delhi, India.
    Rawat M; Department of Internal Medicine, 1 University of New Mexico, Albuquerque, New Mexico, United States of America.
    Rathi B; Bioorganic Research Laboratory, Department of Chemistry, University of Delhi, Delhi, India.
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2015 Oct 26; Vol. 10 (10), pp. e0139347. Date of Electronic Publication: 2015 Oct 26 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antimalarials/*pharmacology
    Aspartic Acid Endopeptidases/*antagonists & inhibitors
    Phthalimides/*pharmacology
    Antimalarials/chemical synthesis ; Antimalarials/chemistry ; Aspartic Acid Endopeptidases/chemistry ; Cell Line ; Drug Design ; Humans ; Inhibitory Concentration 50 ; Models, Molecular ; Molecular Conformation ; Molecular Structure ; Parasitic Sensitivity Tests ; Phthalimides/chemical synthesis ; Phthalimides/chemistry ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/enzymology ; Protein Binding ; Quantitative Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Purification and characterization of a novel and robust L-asparaginase having low-glutaminase activity from Bacillus licheniformis: in vitro evaluation of anti-cancerous properties.
    Autorzy:
    Mahajan RV; Department of Microbiology, University of Delhi South Campus, New Delhi, Delhi, India.
    Kumar V; Department of Microbiology, University of Delhi South Campus, New Delhi, Delhi, India.
    Rajendran V; Department of Biochemistry, University of Delhi South Campus, New Delhi, Delhi, India.
    Saran S; Technology Based Incubator, University of Delhi South Campus, New Delhi, Delhi, India.
    Ghosh PC; Department of Biochemistry, University of Delhi South Campus, New Delhi, Delhi, India.
    Saxena RK; Department of Microbiology, University of Delhi South Campus, New Delhi, Delhi, India.
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2014 Jun 06; Vol. 9 (6), pp. e99037. Date of Electronic Publication: 2014 Jun 06 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*isolation & purification
    Antineoplastic Agents/*pharmacology
    Asparaginase/*isolation & purification
    Asparaginase/*pharmacology
    Bacillus/*enzymology
    Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Asparaginase/chemistry ; Asparaginase/metabolism ; Bacillus/chemistry ; CHO Cells ; Cell Line, Tumor ; Cricetulus ; Enzyme Stability ; Glutaminase/chemistry ; Glutaminase/isolation & purification ; Glutaminase/metabolism ; Glutaminase/pharmacology ; Humans ; Neoplasms/drug therapy ; Substrate Specificity
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Assessment of anti-plasmodial activity of non-hemolytic, non-immunogenic, non-toxic antimicrobial peptides (AMPs LR14) produced by Lactobacillus plantarum LR/14.
    Autorzy:
    Gupta R; Department of Genetics, University of Delhi South Campus, New Delhi, 110021, India.
    Rajendran V
    Ghosh PC
    Srivastava S
    Pokaż więcej
    Źródło:
    Drugs in R&D [Drugs R D] 2014 Jun; Vol. 14 (2), pp. 95-103.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antimalarials/*pharmacology
    Antimicrobial Cationic Peptides/*pharmacology
    Lactobacillus plantarum/*chemistry
    Plasmodium falciparum/*drug effects
    Animals ; Antimalarials/chemistry ; Antimalarials/metabolism ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/metabolism ; Cell Survival/drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Erythrocytes/drug effects ; Erythrocytes/parasitology ; Female ; Humans ; Lactobacillus plantarum/metabolism ; Parasitic Sensitivity Tests ; Rats ; Rats, Wistar ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Efficacy of Liposomal Monensin on the Enhancement of the Antitumour Activity of Liposomal Ricin in Human Epidermoid Carcinoma (KB) Cells.
    Autorzy:
    Tyagi N; Department of Oncologic Sciences, Mitchel Cancer Institute, University of South Alabama, Mobile, Alabama, USA.
    Rathore SS
    Ghosh PC
    Pokaż więcej
    Źródło:
    Indian journal of pharmaceutical sciences [Indian J Pharm Sci] 2013 Jan; Vol. 75 (1), pp. 16-22.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Enhanced killing of human epidermoid carcinoma (KB) cells by treatment with ricin encapsulated into sterically stabilized liposomes in combination with monensin.
    Autorzy:
    Tyagi N; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi-110021, India.
    Rathore SS
    Ghosh PC
    Pokaż więcej
    Źródło:
    Drug delivery [Drug Deliv] 2011 Aug; Vol. 18 (6), pp. 394-404. Date of Electronic Publication: 2011 Mar 26.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
    Carcinoma, Squamous Cell/*drug therapy
    Monensin/*administration & dosage
    Ricin/*administration & dosage
    Antineoplastic Combined Chemotherapy Protocols/chemistry ; Carcinoma, Squamous Cell/metabolism ; Cell Line, Tumor ; Chemistry, Pharmaceutical/methods ; Drug Delivery Systems/methods ; Drug Interactions ; Humans ; KB Cells ; Liposomes/administration & dosage ; Liposomes/chemistry ; Monensin/chemistry ; Polyethylene Glycols/chemistry ; Protein Synthesis Inhibitors/administration & dosage ; Protein Synthesis Inhibitors/chemistry ; Ricin/chemistry ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Inhibition of the Growth of Plasmodium falciparum in Culture by Stearylamine-Phosphatidylcholine Liposomes.
    Autorzy:
    Hasan GM; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India.
    Garg N
    Dogra E
    Surolia R
    Ghosh PC
    Pokaż więcej
    Źródło:
    Journal of parasitology research [J Parasitol Res] 2011; Vol. 2011, pp. 120462. Date of Electronic Publication: 2011 Jun 14.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Mechanistic insights into a novel exporter-importer system of Mycobacterium tuberculosis unravel its role in trafficking of iron.
    Autorzy:
    Farhana A; Laboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
    Kumar S
    Rathore SS
    Ghosh PC
    Ehtesham NZ
    Tyagi AK
    Hasnain SE
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2008 May 07; Vol. 3 (5), pp. e2087. Date of Electronic Publication: 2008 May 07.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    ATP-Binding Cassette Transporters/*metabolism
    Iron/*metabolism
    Mycobacterium tuberculosis/*metabolism
    Amino Acid Sequence ; Animals ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Genome, Bacterial ; Macrophages/microbiology ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Molecular Sequence Data ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/pathogenicity ; Operon ; Polymerase Chain Reaction ; Virulence
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Enhancement of the cytotoxicity of liposomal ricin by the carboxylic ionophore monensin and the lysosomotropic amine NH4Cl in Chinese hamster ovary cells.
    Autorzy:
    Bharadwaj S; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi, India.
    Rathore SS
    Ghosh PC
    Pokaż więcej
    Źródło:
    International journal of toxicology [Int J Toxicol] 2006 Sep-Oct; Vol. 25 (5), pp. 349-59.
    Typ publikacji:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Protein Synthesis Inhibitors/*toxicity
    Ricin/*toxicity
    Ammonium Chloride/pharmacology ; Animals ; Anti-Bacterial Agents/pharmacology ; Brefeldin A/pharmacology ; CHO Cells ; Cricetinae ; Cricetulus ; Exocytosis ; Ionophores/pharmacology ; Leucine/metabolism ; Liposomes ; Monensin/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-20 z 20

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