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Wyszukujesz frazę ""Gibson, Gary E."" wg kryterium: Autor


Tytuł :
Brain [U-13 C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity.
Autorzy :
Nilsen LH; Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Shi Q
Gibson GE
Sonnewald U
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Źródło :
Journal of neuroscience research [J Neurosci Res] 2011 Dec; Vol. 89 (12), pp. 1997-2007. Date of Electronic Publication: 2011 Mar 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*metabolism
Glucose/*metabolism
Ketoglutarate Dehydrogenase Complex/*metabolism
Neurodegenerative Diseases/*metabolism
Animals ; Carbon Radioisotopes ; Chromatography, Gas ; Chromatography, High Pressure Liquid ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.
Autorzy :
Karuppagounder SS; Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.
Xu H
Shi Q
Chen LH
Pedrini S
Pechman D
Baker H
Beal MF
Gandy SE
Gibson GE
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Źródło :
Neurobiology of aging [Neurobiol Aging] 2009 Oct; Vol. 30 (10), pp. 1587-600. Date of Electronic Publication: 2008 Apr 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Alzheimer Disease/*physiopathology
Brain/*physiopathology
Oxidative Stress/*physiology
Plaque, Amyloid/*physiology
Thiamine Deficiency/*physiopathology
Alzheimer Disease/immunology ; Alzheimer Disease/pathology ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Animals ; Aspartic Acid Endopeptidases/metabolism ; Brain/immunology ; Brain/pathology ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; Mice, Transgenic ; Mutation ; Neuroglia/immunology ; Neuroglia/pathology ; Neuroglia/physiology ; Neuroimmunomodulation/physiology ; Neurons/immunology ; Neurons/pathology ; Neurons/physiology ; Peptide Fragments/metabolism ; Plaque, Amyloid/pathology ; Protease Nexins ; Receptors, Cell Surface/genetics ; Thiamine Deficiency/immunology ; Thiamine Deficiency/pathology
Czasopismo naukowe
Tytuł :
Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism.
Autorzy :
Karuppagounder SS; Department of Neurology and Neuroscience, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.
Shi Q
Xu H
Gibson GE
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Źródło :
Neurobiology of disease [Neurobiol Dis] 2007 May; Vol. 26 (2), pp. 353-62. Date of Electronic Publication: 2007 Feb 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Oxidative Phosphorylation*
Oxidative Stress*
Brain/*metabolism
Encephalitis/*metabolism
Neurodegenerative Diseases/*metabolism
Thiamine Deficiency/*metabolism
Animals ; Biomarkers/analysis ; Biomarkers/metabolism ; Brain/pathology ; Cell Death ; Cell Survival ; Cytokines/genetics ; Cytokines/metabolism ; Down-Regulation ; Encephalitis/pathology ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurodegenerative Diseases/pathology ; Posterior Thalamic Nuclei/metabolism ; Posterior Thalamic Nuclei/pathology ; RNA, Messenger/metabolism ; Thalamus/metabolism ; Thalamus/pathology ; Thiamine/metabolism ; Thiamine Deficiency/pathology ; Up-Regulation
Czasopismo naukowe
Tytuł :
Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.
Autorzy :
Kim SY; Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA.
Marekov L
Bubber P
Browne SE
Stavrovskaya I
Lee J
Steinert PM
Blass JP
Beal MF
Gibson GE
Cooper AJ
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Źródło :
Neurochemical research [Neurochem Res] 2005 Oct; Vol. 30 (10), pp. 1245-55.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Aconitate Hydratase*/chemistry
Aconitate Hydratase*/metabolism
Brain/*enzymology
GTP-Binding Proteins/*metabolism
Huntington Disease/*metabolism
Mitochondria/*enzymology
Transglutaminases/*metabolism
Animals ; Brain/anatomy & histology ; Brain/pathology ; Humans ; Huntington Disease/pathology ; Mice ; Molecular Weight ; Peptides/genetics ; Peptides/metabolism ; Rats ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Subcellular Fractions/metabolism
Czasopismo naukowe
Tytuł :
Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells.
Autorzy :
Bunik VI; School of Bioinformatics and Bioengineering and Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119992, Russian Federation. />Denton TT
Xu H
Thompson CM
Cooper AJ
Gibson GE
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Źródło :
Biochemistry [Biochemistry] 2005 Aug 09; Vol. 44 (31), pp. 10552-61.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Brain/*enzymology
Ketoglutarate Dehydrogenase Complex/*antagonists & inhibitors
Ketoglutaric Acids/*chemistry
Organophosphonates/*chemistry
Phosphites/*chemistry
Succinates/*chemistry
Alanine Transaminase/antagonists & inhibitors ; Alanine Transaminase/metabolism ; Animals ; Aspartate Aminotransferases/antagonists & inhibitors ; Aspartate Aminotransferases/metabolism ; Cattle ; Cells, Cultured ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Fibroblasts/drug effects ; Fibroblasts/enzymology ; Humans ; Ketoglutarate Dehydrogenase Complex/isolation & purification ; Ketoglutarate Dehydrogenase Complex/metabolism ; Ketoglutaric Acids/pharmacology ; Organophosphonates/pharmacology ; Phosphites/pharmacology ; Rabbits ; Rats ; Substrate Specificity ; Succinates/pharmacology ; Swine
Czasopismo naukowe
Tytuł :
Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria.
Autorzy :
Krasnikov BF; Department of Neurology and Neurosciences, and Medicine, Weill Medical College of Cornell University, New York City, New York 10021, USA.
Kim SY
McConoughey SJ
Ryu H
Xu H
Stavrovskaya I
Iismaa SE
Mearns BM
Ratan RR
Blass JP
Gibson GE
Cooper AJ
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Źródło :
Biochemistry [Biochemistry] 2005 May 31; Vol. 44 (21), pp. 7830-43.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Brain/*enzymology
Mitochondria, Liver/*enzymology
Transglutaminases/*isolation & purification
Transglutaminases/*metabolism
Animals ; Blotting, Western ; Cadaverine/metabolism ; Calcium/physiology ; Carbon Radioisotopes/metabolism ; Caseins/metabolism ; Cross Reactions ; Electrophoresis, Polyacrylamide Gel ; Fluorescein/metabolism ; GTP-Binding Proteins/immunology ; GTP-Binding Proteins/isolation & purification ; GTP-Binding Proteins/metabolism ; Guinea Pigs ; Immune Sera/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Knockout ; Putrescine/metabolism ; Radioligand Assay ; Submitochondrial Particles/enzymology ; Transglutaminases/deficiency ; Transglutaminases/genetics ; Transglutaminases/immunology
Czasopismo naukowe
Tytuł :
Mitochondrial abnormalities in Alzheimer brain: mechanistic implications.
Autorzy :
Bubber P; Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, NY 10605, USA.
Haroutunian V
Fisch G
Blass JP
Gibson GE
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Źródło :
Annals of neurology [Ann Neurol] 2005 May; Vol. 57 (5), pp. 695-703.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Alzheimer Disease/*pathology
Brain/*pathology
Mitochondria/*pathology
Aged ; Aged, 80 and over ; Aging/pathology ; Alzheimer Disease/enzymology ; Alzheimer Disease/physiopathology ; Animals ; Brain/enzymology ; Brain/physiopathology ; Choline O-Acetyltransferase/metabolism ; Citric Acid Cycle/physiology ; Female ; Humans ; Male ; Mice ; Middle Aged ; Mitochondria/enzymology ; Plaque, Amyloid/pathology ; Postmortem Changes ; Prefrontal Cortex/enzymology ; Prefrontal Cortex/pathology ; Psychiatric Status Rating Scales ; Pyruvate Dehydrogenase Complex/metabolism
Czasopismo naukowe
Tytuł :
Tricarboxylic acid cycle enzymes following thiamine deficiency.
Autorzy :
Bubber P; Department of Neurology and Neuroscience, Burke Medical Research Institute, Weill Medical College, Cornell University, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.
Ke ZJ
Gibson GE
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Źródło :
Neurochemistry international [Neurochem Int] 2004 Dec; Vol. 45 (7), pp. 1021-8.
Typ publikacji :
Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Brain/*enzymology
Citric Acid Cycle/*physiology
Thiamine Deficiency/*enzymology
Animals ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases.
Autorzy :
Gibson GE; Burke Medical Research Institute, Weill Medical College of Cornell University, 785 Mamaroneck Avenue, White Plains, New York 10605, USA.
Huang HM
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Źródło :
Journal of bioenergetics and biomembranes [J Bioenerg Biomembr] 2004 Aug; Vol. 36 (4), pp. 335-40.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
MeSH Terms :
Oxidative Stress*
Brain/*metabolism
Calcium/*metabolism
Endoplasmic Reticulum/*metabolism
Ketoglutarate Dehydrogenase Complex/*metabolism
Mitochondria/*enzymology
Neurodegenerative Diseases/*metabolism
Neurons/*metabolism
Adaptation, Physiological/drug effects ; Animals ; Antioxidants/pharmacology ; Apoptosis ; Cell Hypoxia/drug effects ; Cell Membrane Permeability ; Cell Respiration/drug effects ; Humans ; Mitochondria/drug effects ; Mitochondrial Proteins/metabolism ; Models, Biological ; Neuroprotective Agents/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism.
Autorzy :
Ke ZJ; Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA. />Gibson GE
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Źródło :
Neurochemistry international [Neurochem Int] 2004 Jul-Aug; Vol. 45 (2-3), pp. 361-9.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
MeSH Terms :
Brain/*cytology
Brain/*physiology
Nerve Degeneration/*pathology
Nerve Degeneration/*physiopathology
Neurodegenerative Diseases/*metabolism
Animals ; Astrocytes/metabolism ; Astrocytes/pathology ; Brain/pathology ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Humans ; Microglia/metabolism ; Neurodegenerative Diseases/pathology ; Oxidation-Reduction ; Thalamus/metabolism ; Thalamus/pathology ; Thiamine Deficiency/metabolism ; Thiamine Deficiency/pathology
Czasopismo naukowe
Tytuł :
Reversal of thiamine deficiency-induced neurodegeneration.
Autorzy :
Ke ZJ; Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York, USA.
DeGiorgio LA
Volpe BT
Gibson GE
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Źródło :
Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2003 Feb; Vol. 62 (2), pp. 195-207.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Brain/*enzymology
Cell Death/*physiology
Neurodegenerative Diseases/*enzymology
Recovery of Function/*physiology
Thiamine/*metabolism
Thiamine Deficiency/*enzymology
Animals ; Brain/pathology ; Brain/physiopathology ; Cell Death/drug effects ; Disease Models, Animal ; Fluoresceins ; Fluorescent Dyes/metabolism ; Heme Oxygenase (Decyclizing)/metabolism ; Heme Oxygenase-1 ; Immunohistochemistry ; Male ; Membrane Proteins ; Mice ; Microglia/drug effects ; Microglia/enzymology ; Microglia/pathology ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/physiopathology ; Neurons/drug effects ; Neurons/enzymology ; Neurons/pathology ; Organic Chemicals ; Recovery of Function/drug effects ; Thiamine/pharmacology ; Thiamine Deficiency/drug therapy ; Thiamine Deficiency/physiopathology
Czasopismo naukowe
Tytuł :
A mitocentric view of Alzheimer's disease suggests multi-faceted treatments.
Autorzy :
Gibson GE
Shi Q
Gibson, Gary E
Shi, Qingli
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Temat :
ALZHEIMER'S disease treatment
CALCIUM metabolism
GLUCOSE metabolism
ALZHEIMER'S disease
ANIMALS
BIOLOGICAL models
BRAIN
COGNITION
CYTOPLASM
MITOCHONDRIA
MITOCHONDRIAL pathology
PEPTIDES
RESEARCH funding
OXIDATIVE stress
GLUCOSE metabolism disorders
DISEASE complications
Źródło :
Journal of Alzheimer's Disease; 2010, Vol. 20 Issue 2, p591-607, 17p
Czasopismo naukowe

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