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Podgląd okładki
Tytuł :
Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures
Autorzy :
Giralt, Albert
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Źródło :
In Toxicology Letters 1 February 2021 337:98-110
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy
Autorzy :
Fernández-García, SaraAff1, Aff2, Aff3
Sancho-Balsells, AnnaAff1, Aff2, Aff3
Longueville, SophieAff4, Aff5, Aff6
Hervé, DenisAff4, Aff5, Aff6
Gruart, Agnès
Delgado-García, José María
Alberch, JordiAff1, Aff2, Aff3, Aff8
Giralt, AlbertAff1, Aff2, Aff3, Aff8
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Źródło :
Cell Death & Disease. 11(6)
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Cyclin-Dependent Kinase 5 Dysfunction Contributes to Depressive-like Behaviors in Huntington’s Disease by Altering the DARPP-32 Phosphorylation Status in the Nucleus Accumbens
Autorzy :
Brito, Veronica
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Źródło :
In Biological Psychiatry 1 August 2019 86(3):196-207
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Pyk2 in the amygdala modulates chronic stress sequelae via PSD-95-related micro-structural changes
Autorzy :
Montalban, EnricaAff1, Aff2, Aff3
Al-Massadi, OmarAff1, Aff2, Aff3, Aff4, Aff5
Sancho-Balsells, AnnaAff6, Aff7, Aff8
Brito, VerónicaAff6, Aff7, Aff8
de Pins, BenoitAff1, Aff2, Aff3
Alberch, JordiAff6, Aff7, Aff8
Ginés, SilviaAff6, Aff7, Aff8
Girault, Jean-AntoineAff1, Aff2, Aff3
Giralt, AlbertAff1, Aff2, Aff3, Aff6, Aff7, Aff8
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Źródło :
Translational Psychiatry. 9(1)
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Early Downregulation of p75 by Genetic and Pharmacological Approaches Delays the Onset of Motor Deficits and Striatal Dysfunction in Huntington’s Disease Mice
Autorzy :
Suelves, NuriaAff1, Aff2, Aff3
Miguez, AndrésAff1, Aff2, Aff3
López-Benito, SarayAff4, Aff5
Barriga, Gerardo García-DíazAff1, Aff2, Aff3
Giralt, AlbertAff1, Aff2, Aff3
Alvarez-Periel, ElenaAff1, Aff2, Aff3
Arévalo, Juan CarlosAff4, Aff5
Alberch, JordiAff1, Aff2, Aff3
Ginés, SilviaAff1, Aff2, Aff3
Brito, VerónicaAff1, Aff2, Aff3
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Źródło :
Molecular Neurobiology. 56(2):935-953
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
The AMPA receptor positive allosteric modulator S 47445 rescues in vivo CA3-CA1 long-term potentiation and structural synaptic changes in old mice
Autorzy :
Giralt, Albert
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Źródło :
In Neuropharmacology 1 September 2017 123:395-409
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Activation of Elk-1 participates as a neuroprotective compensatory mechanism in models of Huntington's disease
Autorzy :
ANGLADA-HUGUET, Marta
GIRALT, Albert
PEREZ-NAVARRO, Esther
ALBERCH, Jordi
XIFRO, Xavier
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Temat :
Encéphale
Encephalon
Encéfalo
Enzyme
Enzima
Hydrolases
Maladie dégénérative
Degenerative disease
Enfermedad degenerativa
Maladie héréditaire
Genetic disease
Enfermedad hereditaria
Mammalia
Noyau gris central
Basal ganglion
Núcleo basal
Pathologie de l'encéphale
Cerebral disorder
Encéfalo patología
Pathologie du système nerveux central
Central nervous system disease
Sistema nervosio central patología
Pathologie du système nerveux
Nervous system diseases
Sistema nervioso patología
Peptidases
Rodentia
Syndrome extrapyramidal
Extrapyramidal syndrome
Extrapiramidal síndrome
Système nerveux central
Central nervous system
Sistema nervioso central
Vertebrata
Activation
Activación
Caspase
Chorée de Huntington
Huntington disease
Corea Huntington
Corps strié
Corpus striatum
Cuerpo estriado
Facteur transcription
Transcription factor
Factor transcripción
Gène immédiat précoce
Immediate early gene
Gen inmediato precoz
Localisation
Localization
Localización
Modèle animal
Animal model
Modelo animal
Mort cellulaire
Cell death
Muerte celular
Phosphorylation
Fosforilación
Protéine nucléaire
Nuclear protein
Proteína nuclearia
Souris
Mouse
Ratón
Transcription
Transcripción
Transfection
Transfección
R6 mouse
huntingtin
immediate early genes
knock-in cells
neuroprotection
transcription
Sciences biologiques et medicales
Biological and medical sciences
Sciences medicales
Medical sciences
Neurologie
Neurology
Maladies dégénératives et hérédodégénératives du système nerveux. Leucodystrophies. Maladies à prions
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Psychopathologie. Psychiatrie
Psychopathology. Psychiatry
Etude clinique de l'adulte et de l'adolescent
Adult and adolescent clinical studies
Troubles mentaux organiques. Neuropsychologie
Organic mental disorders. Neuropsychology
Psychologie. Psychanalyse. Psychiatrie
Psychology. Psychoanalysis. Psychiatry
PSYCHOPATHOLOGIE. PSYCHIATRIE
Cell biology, histology
Biologie cellulaire, histologie
Physiology, morphology
Physiologie, morphologie
Źródło :
Journal of neurochemistry. 121(3-4):639-648
Materiał oryginalny :
INIST-CNRS
Opis pliku :
text
Dostęp URL :
http://pascal-francis.inist.fr/vibad/index.php?action=search&terms=25821672
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels
Autorzy :
Carretón, Olga
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Źródło :
In Experimental Neurology October 2012 237(2):335-345
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction
Autorzy :
Lao-Peregrin Cristina
Carretón Olga
Giralt Albert
Martín Eduardo D
Alberch Jordi
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Temat :
Huntingtin
synaptic plasticity
therapy
astrocytes
learning
Long-term potentiation
Neurology. Diseases of the nervous system
RC346-429
Geriatrics
RC952-954.6
Źródło :
Molecular Neurodegeneration, Vol 6, Iss 1, p 71 (2011)
Opis pliku :
electronic resource
Relacje :
http://www.molecularneurodegeneration.com/content/6/1/71; https://doaj.org/toc/1750-1326
Dostęp URL :
https://doaj.org/article/a86298dc5d234023af8987110aca1000
Czasopismo naukowe
Szczegóły Pełny tekst
Podgląd okładki
Tytuł :
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.
Autorzy :
Marco, Sonia
Giralt, Albert
Petrovic, Milos M
Pouladi, Mahmoud A
Martínez-Turrillas, Rebeca
Martínez-Hernández, José
Kaltenbach, Linda S
Torres-Peraza, Jesús
Graham, Rona K
Watanabe, Masahiko
Luján, Rafael
Nakanishi, Nobuki
Lipton, Stuart A
Lo, Donald C
Hayden, Michael R
Alberch, Jordi
Wesseling, John F
Pérez-Otaño, Isabel
Pokaż więcej
Źródło :
Nature Medicine. Aug2013, Vol. 19 Issue 8, p1030-1038. 9p. 6 Graphs.
Czasopismo naukowe
Szczegóły Pełny tekst
Podgląd okładki
Tytuł :
Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.
Autorzy :
Martı́n-Ibáñez, Raquel
Pardo, Mónica
Giralt, Albert
Miguez, Andrés
Guardia, Inés
Marion-Poll, Lucile
Herranz, Cristina
Esgleas, Miriam
Garcia-Dı́az Barriga, Gerardo
Edel, Michael J.
Vicario-Abejón, Carlos
Alberch, Jordi
Girault, Jean-Antoine
Susan Chan
Kastner, Philippe
Canals, Josep M.
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Temat :
ZINC-finger proteins
PROTEIN expression
DEVELOPMENTAL neurobiology
GENETIC overexpression
CELL physiology
Źródło :
Development (09501991); 2017, Vol. 144 Issue 8, p1566-1577, 12p, 8 Graphs
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Meridianins and Lignarenone B as Potential GSK3β Inhibitors and Inductors of Structural Neuronal Plasticity.
Autorzy :
Llorach-Pares, Laura
Rodriguez-Urgelles, Ened
Nonell-Canals, Alfons
Alberch, Jordi
Avila, Conxita
Sanchez-Martinez, Melchor
Giralt, Albert
Pokaż więcej
Temat :
NEUROPLASTICITY
GLYCOGEN synthase kinase
TAU proteins
INDOLE alkaloids
METABOLITES
ADENOSINE triphosphate
Źródło :
Biomolecules (2218-273X); Apr2020, Vol. 10 Issue 4, p639, 1p
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.
Autorzy :
Sánchez-Danés, Adriana
Richaud-Patin, Yvonne
Carballo-Carbajal, Iria
Jiménez-Delgado, Senda
Caig, Carles
Mora, Sergio
Di Guglielmo, Claudia
Ezquerra, Mario
Patel, Bindiben
Giralt, Albert
Canals, Josep M.
Memo, Maurizio
Alberch, Jordi
López-Barneo, José
Vila, Miquel
Cuervo, Ana Maria
Tolosa, Eduard
Consiglio, Antonella
Raya, Angel
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Źródło :
EMBO Molecular Medicine; May2012, Vol. 4 Issue 5, p380-395, 16p
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
P1‐092: NEUROPROTECTIVE EFFECTS OF PKR KNOCKOUT IN 5XFAD ALZHEIMER MICE AND NEURON‐MICROGLIA CO‐CULTURES.
Autorzy :
Tible, Marion
Mouton-Liger, Francois
Schmitt, Julien
Giralt, Albert
Thomasseau, Sylvie
Paquet, Claire
Reig, Laure Rondi
Meurs, Eliane
Girault, Jean Antoine
Hugon, Jacques
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Źródło :
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Jul2018 Supplement 7s Part5, Vol. 14, pP306-P306, 1p
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.
Autorzy :
Rué, Laura
Bañez-Coronel, Mónica
Creus-Muncunill, Jordi
Giralt, Albert
Alcalá-Vida, Rafael
Mentxaka, Gartze
Kagerbauer, Birgit
Zomeño-Abellán, M. Teresa
Aranda, Zeus
Venturi, Veronica
Pérez-Navarro, Esther
Estivill, Xavier
Martí, Eulàlia
Pokaż więcej
Temat :
HUNTINGTON disease
POLYGLUTAMINE
MUTANT proteins
OLIGONUCLEOTIDES
NON-coding RNA
Źródło :
Journal of Clinical Investigation. Nov2016, Vol. 126 Issue 11, p4319-4330. 12p. 1 Chart, 5 Graphs.
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Dissociation between CA3-CA1 Synaptic Plasticity and Associative Learning in TgNTRK3 Transgenic Mice.
Autorzy :
Sahún, Ignasi
Delgado-García, José María
Amador-Arjona, Alejandro
Giralt, Albert
Alberch, Jordi
Dierssen, Mara
Gruart, Agnès
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Temat :
NEUROPLASTICITY
NEUROPHYSIOLOGY
NEURAL transmission
TRANSGENIC mice
PHOSPHORYLATION
LABORATORY rats
Źródło :
Journal of Neuroscience; 2/28/2007, Vol. 27 Issue 9, p17-17, 1p
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival.
Autorzy :
Martínez-Carreres L; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Puyal J; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Leal-Esteban LC; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Orpinell M; Department of Physiology, University of Lausanne, Lausanne, Switzerland.
Castillo-Armengol J; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Giralt A; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Dergai O; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Moret C; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Barquissau V; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Nasrallah A; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Pabois A; Department of Fundamental Oncology, University of Lausanne, Epalinges, Switzerland.; Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
Zhang L; Department of Fundamental Oncology, University of Lausanne, Epalinges, Switzerland.
Romero P; Department of Fundamental Oncology, University of Lausanne, Epalinges, Switzerland.
Lopez-Mejia IC; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Fajas L; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. .
Pokaż więcej
Źródło :
Cancer research [Cancer Res] 2019 Oct 15; Vol. 79 (20), pp. 5245-5259. Date of Electronic Publication: 2019 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclin-Dependent Kinase 4/*physiology
Lysosomes/*physiology
Mechanistic Target of Rapamycin Complex 1/*metabolism
Neoplasm Proteins/*physiology
Adenylate Kinase/metabolism ; Aminopyridines/pharmacology ; Aminopyridines/therapeutic use ; Animals ; Autophagosomes/physiology ; Autophagy/physiology ; Benzimidazoles/pharmacology ; Benzimidazoles/therapeutic use ; Cell Line, Tumor ; Cellular Senescence/physiology ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Cyclin-Dependent Kinase 4/genetics ; Drug Synergism ; Female ; Gene Knockout Techniques ; Humans ; Insulin/physiology ; Lysosomes/ultrastructure ; Mice ; Mice, Inbred NOD ; Molecular Targeted Therapy ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein Processing, Post-Translational ; Protein Transport ; Proto-Oncogene Proteins/metabolism ; Pyrones/pharmacology ; Pyrones/therapeutic use ; Recombinant Fusion Proteins/metabolism ; Signal Transduction/physiology ; Thiophenes/pharmacology ; Thiophenes/therapeutic use ; Tumor Suppressor Proteins/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Early Downregulation of p75 by Genetic and Pharmacological Approaches Delays the Onset of Motor Deficits and Striatal Dysfunction in Huntington's Disease Mice.
Autorzy :
Suelves N; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Miguez A; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
López-Benito S; Department of Cell Biology and Pathology, Instituto de Neurociencias de Castilla y León (INCyL), University of Salamanca, Salamanca, Spain.; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Barriga GG; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Giralt A; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Alvarez-Periel E; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Arévalo JC; Department of Cell Biology and Pathology, Instituto de Neurociencias de Castilla y León (INCyL), University of Salamanca, Salamanca, Spain.; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Alberch J; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Ginés S; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Brito V; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain. .; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. .; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. .
Pokaż więcej
Źródło :
Molecular neurobiology [Mol Neurobiol] 2019 Feb; Vol. 56 (2), pp. 935-953. Date of Electronic Publication: 2018 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Brain-Derived Neurotrophic Factor/*pharmacology
Corpus Striatum/*physiopathology
Down-Regulation/*drug effects
Receptors, Nerve Growth Factor/*genetics
Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Corpus Striatum/metabolism ; Dendritic Spines/metabolism ; Disease Models, Animal ; Gene Knock-In Techniques ; Huntington Disease/genetics ; Mice, Transgenic ; Neurons/metabolism ; Receptor, trkB/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway.
Autorzy :
García-Díaz Barriga G; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Giralt A; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Anglada-Huguet M; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Gaja-Capdevila N; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Orlandi JG; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Soriano J; Departament de Física de la Matèria Condensada, Universitat de Barcelona, Barcelona, Spain.; Institute of Complex Systems (UBICS), Universitat de Barcelona, Barcelona, Spain.
Canals JM; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Alberch J; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Pokaż więcej
Źródło :
Human molecular genetics [Hum Mol Genet] 2017 Aug 15; Vol. 26 (16), pp. 3144-3160.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Flavones/*metabolism
Flavones/*therapeutic use
Huntington Disease/*metabolism
Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Cognition/drug effects ; Corpus Striatum/metabolism ; Disease Models, Animal ; Flavones/pharmacology ; Hippocampus/metabolism ; Huntington Disease/drug therapy ; Mice ; Mice, Transgenic ; Motor Neurons/drug effects ; Phospholipase C gamma/drug effects ; Phospholipase C gamma/metabolism ; Phosphorylation ; Receptor, trkB/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.
Autorzy :
Martín-Ibáñez R; Stem Cells and Regenerative Medicine Laboratory, Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.; Neuroscience Institute, University of Barcelona, 08036 Barcelona, Spain.; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain.; Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Spain.; Research and Development Unit, Production and Validation Center of Advanced Therapies (Creatio), Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.
Pardo M; Stem Cells and Regenerative Medicine Laboratory, Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.; Neuroscience Institute, University of Barcelona, 08036 Barcelona, Spain.; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain.; Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Spain.
Giralt A; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain.; Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Spain.; Pathophysiology of Neurodegenerative Diseases Laboratory, Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.
Miguez A; Stem Cells and Regenerative Medicine Laboratory, Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.; Neuroscience Institute, University of Barcelona, 08036 Barcelona, Spain.; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain.; Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Spain.
Guardia I; Stem Cells and Regenerative Medicine Laboratory, Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.; Neuroscience Institute, University of Barcelona, 08036 Barcelona, Spain.; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain.; Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Spain.
Marion-Poll L; Inserm UMR-S839; Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités; Institut du Fer à Moulin, 75005 Paris, France.
Herranz C; Stem Cells and Regenerative Medicine Laboratory, Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.; Neuroscience Institute, University of Barcelona, 08036 Barcelona, Spain.; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain.; Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Spain.; Research and Development Unit, Production and Validation Center of Advanced Therapies (Creatio), Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.
Esgleas M; Stem Cells and Regenerative Medicine Laboratory, Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain.; Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Spain.
Garcia-Díaz Barriga G; Neuroscience Institute, University of Barcelona, 08036 Barcelona, Spain.; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain.; Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Spain.; Pathophysiology of Neurodegenerative Diseases Laboratory, Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.
Edel MJ; Control of Pluripotency Laboratory, Department of Biomedical Sciences, Faculty of Medicine and Health Science, University of Barcelona, 08036 Barcelona, Spain.; Victor Chang Cardiac Research Institute, Sydney, New South Wales, 2010 Australia.; School of Medicine and Pharmacology, Anatomy, Physiology and Human Biology, CCTRM, University of Western Australia, Western Australia, 6009 Australia.
Vicario-Abejón C; Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Spain.; Departamento de Neurobiología Molecular, Celular y del Desarrollo, Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), 28002 Madrid, Spain.
Alberch J; Neuroscience Institute, University of Barcelona, 08036 Barcelona, Spain.; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain.; Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Spain.
Girault JA; Inserm UMR-S839; Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités; Institut du Fer à Moulin, 75005 Paris, France.
Chan S; Stem Cells and Regenerative Medicine Laboratory, Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.; Neuroscience Institute, University of Barcelona, 08036 Barcelona, Spain.
Kastner P; Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Inserm U964, Centre National de la Recherche Scientifique (CNRS) UMR 7104, 67400 Illkirch-Graffenstaden, France.; Faculté de Médecine, Université de Strasbourg, 67081 Strasbourg, France.
Canals JM; Stem Cells and Regenerative Medicine Laboratory, Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain .; Neuroscience Institute, University of Barcelona, 08036 Barcelona, Spain.; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain.; Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Spain.; Research and Development Unit, Production and Validation Center of Advanced Therapies (Creatio), Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.
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Źródło :
Development (Cambridge, England) [Development] 2017 Apr 15; Vol. 144 (8), pp. 1566-1577. Date of Electronic Publication: 2017 Mar 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Corpus Striatum/*cytology
DNA-Binding Proteins/*metabolism
Globus Pallidus/*cytology
Neurons/*cytology
Neurons/*metabolism
Transcription Factors/*metabolism
Animals ; Animals, Newborn ; Cell Count ; Cell Cycle Checkpoints ; Cell Death ; Cell Proliferation ; Cyclin E/metabolism ; G1 Phase ; Mice, Knockout ; Motor Activity ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Neurogenesis ; Phenotype ; S Phase
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.
Autorzy :
Anglada-Huguet M; Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address: .
Giralt A; Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address: albert.giralt@inserm.fr.
Rué L; Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address: .
Alberch J; Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address: .
Xifró X; Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain; TargetsLab, Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Spain. Electronic address: .
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Źródło :
Biochimica et biophysica acta [Biochim Biophys Acta] 2016 Jul; Vol. 1862 (7), pp. 1255-66. Date of Electronic Publication: 2016 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Huntington Disease/*genetics
Huntington Disease/*physiopathology
Ribosomal Protein S6 Kinases, 90-kDa/*genetics
Animals ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Cells, Cultured ; Corpus Striatum/metabolism ; Corpus Striatum/physiopathology ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Gene Knock-In Techniques ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/metabolism ; Male ; Mice, Inbred C57BL ; Motor Activity ; Mutation ; Ribosomal Protein S6 Kinases, 90-kDa/metabolism ; Synapses/genetics ; Synapses/metabolism ; Synapses/pathology ; Transcriptional Activation
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Cryostat Slice Irregularities May Introduce Bias in Tissue Thickness Estimation: Relevance for Cell Counting Methods.
Autorzy :
Puigdellívol-Sánchez A; 1Human Anatomy and Embryology Unit,Facultat de Medicina,Universitat de Barcelona,c/Casanova 143,08036 Barcelona,Spain.
Giralt A; 3Departament de Biologia Cellular,Immunologia i Neurociències,Facultat de Medicina,Universitat de Barcelona,c/Casanova 143,08036 Barcelona,Spain.Barcelona,Spain.
Casanovas A; 6Unit of Cellular Neurobioloy,Departament de Medicina Experimental,Facultat de Medicina,Universitat de Lleida,c/Montserrat Roig 2,25008 Lleida,Spain.
Alberch J; 3Departament de Biologia Cellular,Immunologia i Neurociències,Facultat de Medicina,Universitat de Barcelona,c/Casanova 143,08036 Barcelona,Spain.Barcelona,Spain.
Prats-Galino A; 1Human Anatomy and Embryology Unit,Facultat de Medicina,Universitat de Barcelona,c/Casanova 143,08036 Barcelona,Spain.
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Źródło :
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada [Microsc Microanal] 2015 Aug; Vol. 21 (4), pp. 893-901. Date of Electronic Publication: 2015 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Count/*methods
Cryoultramicrotomy/*methods
Image Cytometry/*methods
Microscopy/*methods
Animals ; Nerve Tissue/cytology ; Rodentia
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Cognitive Dysfunction in Huntington's Disease: Humans, Mouse Models and Molecular Mechanisms.
Autorzy :
Giralt A; Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.
Saavedra A; Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
Alberch J; Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
Pérez-Navarro E; Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
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Źródło :
Journal of Huntington's disease [J Huntingtons Dis] 2012; Vol. 1 (2), pp. 155-73.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cognition*
Cognition Disorders/*physiopathology
Corpus Striatum/*physiopathology
Hippocampus/*physiopathology
Huntington Disease/*physiopathology
Nerve Tissue Proteins/*metabolism
Animals ; Cognition Disorders/etiology ; Disease Models, Animal ; Humans ; Huntington Disease/complications ; Mice ; Models, Neurological ; Nerve Net/physiopathology ; Neural Pathways/physiopathology ; Species Specificity ; Synaptic Transmission
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype.
Autorzy :
Giralt A; Departament de Bioquímica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, and CIBER Fisiopatologia de la Obesidad y Nutrición, 08028 Barcelona, Spain.
Hondares E
Villena JA
Ribas F
Díaz-Delfín J
Giralt M
Iglesias R
Villarroya F
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2011 May 13; Vol. 286 (19), pp. 16958-66. Date of Electronic Publication: 2011 Mar 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Adipose Tissue, Brown/*metabolism
Sirtuin 3/*metabolism
Transcription Factors/*metabolism
Animals ; Cell Nucleus/metabolism ; Cloning, Molecular ; Cyclic AMP/metabolism ; Fibroblasts/cytology ; Mice ; Mice, Inbred C57BL ; Models, Biological ; Phenotype ; RNA, Messenger/metabolism ; Receptors, Estrogen/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling.
Autorzy :
Torres-Peraza JF; Departament de Biologia Cellular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.
Giralt A
García-Martínez JM
Pedrosa E
Canals JM
Alberch J
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Źródło :
Neurobiology of disease [Neurobiol Dis] 2008 Mar; Vol. 29 (3), pp. 409-21. Date of Electronic Publication: 2007 Oct 23.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Corpus Striatum/*physiology
Mutation/*physiology
Nerve Tissue Proteins/*genetics
Nerve Tissue Proteins/*metabolism
Nuclear Proteins/*genetics
Receptors, Glutamate/*physiology
Receptors, N-Methyl-D-Aspartate/*physiology
Synaptic Transmission/*genetics
Adult ; Aged ; Animals ; Corpus Striatum/pathology ; Humans ; Huntingtin Protein ; Male ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/physiology ; Nuclear Proteins/physiology ; Receptors, N-Methyl-D-Aspartate/biosynthesis ; Receptors, N-Methyl-D-Aspartate/genetics ; Signal Transduction/physiology ; Synapses/genetics ; Synapses/metabolism ; Synapses/pathology
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Dissociation between CA3-CA1 synaptic plasticity and associative learning in TgNTRK3 transgenic mice.
Autorzy :
Sahún I; Genes and Disease Program, Genomic Regulation Center, Universidad Pompeu Fabra, Barcelona Biomedical Research Park, 08003 Barcelona, Spain.
Delgado-García JM
Amador-Arjona A
Giralt A
Alberch J
Dierssen M
Gruart A
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2007 Feb 28; Vol. 27 (9), pp. 2253-60.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Association Learning/*physiology
Hippocampus/*physiology
Neuronal Plasticity/*physiology
Synapses/*physiology
Animals ; Conditioning, Classical ; Evoked Potentials ; Hippocampus/cytology ; Long-Term Potentiation/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; N-Methylaspartate/genetics ; N-Methylaspartate/metabolism ; Nerve Growth Factors/metabolism ; Receptor, trkC/genetics ; Receptor, trkC/metabolism
Czasopismo naukowe
Szczegóły
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