TRAF6 Phosphorylation Prevents Its Autophagic Degradation and Re-Shapes LPS-Triggered Signaling Networks.
Autorzy:
Busch J; Institute of Biochemistry, Member of the German Center for Lung Research, Justus Liebig University, 35392 Giessen, Germany. Moreno R; Division of Cellular Medicine, Ninewells Hospital and Medical School, University of Dundee, James Arrott Drive, Dundee DD1 9SY, UK. de la Vega L; Division of Cellular Medicine, Ninewells Hospital and Medical School, University of Dundee, James Arrott Drive, Dundee DD1 9SY, UK. Saul VV; Institute of Biochemistry, Member of the German Center for Lung Research, Justus Liebig University, 35392 Giessen, Germany. Bacher S; Institute of Biochemistry, Member of the German Center for Lung Research, Justus Liebig University, 35392 Giessen, Germany. von Zweydorf F; German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany. Ueffing M; Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, 72076 Tübingen, Germany. Weber A; Rudolf Buchheim Institute of Pharmacology, Member of the German Center for Lung Research, Justus Liebig University, 35392 Giessen, Germany. GloecknerCJ; German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.; Core Facility for Medical Bioanalytics, Center for Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, 72076 Tübingen, Germany. Linne U; Mass Spectrometry Facility of the Department of Chemistry, Philipps University, 35043 Marburg, Germany. Kracht M; Rudolf Buchheim Institute of Pharmacology, Member of the German Center for Lung Research, Justus Liebig University, 35392 Giessen, Germany. Schmitz ML; Institute of Biochemistry, Member of the German Center for Lung Research, Justus Liebig University, 35392 Giessen, Germany.
Pokaż więcej
Źródło:
Cancers [Cancers (Basel)] 2021 Jul 19; Vol. 13 (14). Date of Electronic Publication: 2021 Jul 19.
The LRRK2 N-terminal domain influences vesicle trafficking: impact of the E193K variant.
Autorzy:
Marku A; Department of Excellence of Pharmacological and Biomolecular Sciences Università degli Studi di Milano, Milano, Italy. Carrion MDP; CIBIO, Università degli Studi di Trento, Italy & Dulbecco Telethon Institute, Trento, Italy.; Facultad de Farmacia, Universidad CEU San Pablo, Madrid, Spain. Pischedda F; CIBIO, Università degli Studi di Trento, Italy & Dulbecco Telethon Institute, Trento, Italy. Marte A; Department of Experimental Medicine, University of Genova, Genova, Italy.; IRCCS Ospedale Policlinico San Martino, 16132, Genova, Italy. Casiraghi Z; Department of Excellence of Pharmacological and Biomolecular Sciences Università degli Studi di Milano, Milano, Italy. Marciani P; Department of Excellence of Pharmacological and Biomolecular Sciences Università degli Studi di Milano, Milano, Italy. von Zweydorf F; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. GloecknerCJ; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; University of Tübingen, Center for Ophthalmology, Institute for Ophthalmic Research, 72076, Tübingen, Germany. Onofri F; Department of Experimental Medicine, University of Genova, Genova, Italy.; IRCCS Ospedale Policlinico San Martino, 16132, Genova, Italy. Perego C; Department of Excellence of Pharmacological and Biomolecular Sciences Università degli Studi di Milano, Milano, Italy. . Piccoli G; CIBIO, Università degli Studi di Trento, Italy & Dulbecco Telethon Institute, Trento, Italy. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2020 Mar 02; Vol. 10 (1), pp. 3799. Date of Electronic Publication: 2020 Mar 02.
Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis.
Autorzy:
Balta EA; Institute of Biochemistry, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany. Schäffner I; Institute of Biochemistry, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany. Wittmann MT; Institute of Biochemistry, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany. Sock E; Institute of Biochemistry, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany. von Zweydorf F; DZNE-German Center for Neurodegenerative Diseases, 72076, Tübingen, Germany. von Wittgenstein J; Institute of Biochemistry, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany. Steib K; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany. Heim B; University of Tübingen, Institute for Ophthalmic Research, Center for Ophthalmology, 72076, Tübingen, Germany. Kremmer E; Monoclonal Antibody Core Facility, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany. Häberle BM; Institute of Biochemistry, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany. Ueffing M; University of Tübingen, Institute for Ophthalmic Research, Center for Ophthalmology, 72076, Tübingen, Germany. Lie DC; Institute of Biochemistry, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany. . GloecknerCJ; DZNE-German Center for Neurodegenerative Diseases, 72076, Tübingen, Germany. johannes.gloeckner@dzne.de.; University of Tübingen, Institute for Ophthalmic Research, Center for Ophthalmology, 72076, Tübingen, Germany. johannes.gloeckner@dzne.de.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2018 Nov 01; Vol. 8 (1), pp. 16196. Date of Electronic Publication: 2018 Nov 01.
Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons.
Autorzy:
Jung M; 1Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany. Häberle BM; 1Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany. Tschaikowsky T; 1Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany. Wittmann MT; 1Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; 2Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Balta EA; 1Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany. Stadler VC; 1Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany. Zweier C; 2Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Dörfler A; Department of Neuroradiology, University Clinic Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany. GloecknerCJ; 4German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany.; 5Institute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen, 72076 Tübingen, Germany. Lie DC; 1Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Pokaż więcej
Źródło:
Molecular autism [Mol Autism] 2018 Mar 22; Vol. 9, pp. 20. Date of Electronic Publication: 2018 Mar 22 (Print Publication: 2018).
Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.
Autorzy:
Marrone L; DFG-Center for Regenerative Therapies Technische Universität Dresden (CRTD), Dresden, Germany. Bus C; Department of Neurodegenerative Diseases, Centre of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Schöndorf D; Department of Neurodegenerative Diseases, Centre of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Fitzgerald JC; Department of Neurodegenerative Diseases, Centre of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Kübler M; Department of Neurodegenerative Diseases, Centre of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Schmid B; Department of Neurodegenerative Diseases, Centre of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. Reinhardt P; DFG-Center for Regenerative Therapies Technische Universität Dresden (CRTD), Dresden, Germany. Reinhardt L; DFG-Center for Regenerative Therapies Technische Universität Dresden (CRTD), Dresden, Germany.; Max Planck Institute for Molecular Biomedicine, Münster, Germany. Deleidi M; Department of Neurodegenerative Diseases, Centre of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Levin T; DFG-Center for Regenerative Therapies Technische Universität Dresden (CRTD), Dresden, Germany. Meixner A; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Klink B; Institut für Klinische Genetik, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Glatza M; DFG-Center for Regenerative Therapies Technische Universität Dresden (CRTD), Dresden, Germany.; Max Planck Institute for Molecular Biomedicine, Münster, Germany. GloecknerCJ; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany. Gasser T; Department of Neurodegenerative Diseases, Centre of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Sterneckert J; DFG-Center for Regenerative Therapies Technische Universität Dresden (CRTD), Dresden, Germany.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2018 Mar 07; Vol. 13 (3), pp. e0192497. Date of Electronic Publication: 2018 Mar 07 (Print Publication: 2018).
LRRK2 transport is regulated by its novel interacting partner Rab32.
Autorzy:
Waschbüsch D; Department of Experimental Tumorbiology, Westfälische Wilhelms University Muenster, Muenster, Germany. Michels H; Department of Experimental Tumorbiology, Westfälische Wilhelms University Muenster, Muenster, Germany. Strassheim S; Department of Experimental Tumorbiology, Westfälische Wilhelms University Muenster, Muenster, Germany. Ossendorf E; Department of Experimental Tumorbiology, Westfälische Wilhelms University Muenster, Muenster, Germany. Kessler D; Department of Experimental Tumorbiology, Westfälische Wilhelms University Muenster, Muenster, Germany. GloecknerCJ; Research Unit Protein Science, Helmholtz Zentrum München, Neuherberg, Germany; Medical Proteome Center, Institute for Ophthalmic Research, Eberhard Karls University Tübingen, Tübingen, Germany. Barnekow A; Department of Experimental Tumorbiology, Westfälische Wilhelms University Muenster, Muenster, Germany.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2014 Oct 31; Vol. 9 (10), pp. e111632. Date of Electronic Publication: 2014 Oct 31 (Print Publication: 2014).
Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies
