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Wyszukujesz frazę ""Glucagon-Like Peptide 1"" wg kryterium: Temat


Tytuł :
Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes.
Autorzy :
Mansouri M; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Hussherr MD; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Strittmatter T; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Buchmann P; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Xue S; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Camenisch G; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Fussenegger M; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. .; Faculty of Science, University of Basel, Basel, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3388. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*radiation effects
Diabetes Mellitus, Type 2/*therapy
Glucagon-Like Peptide 1/*therapeutic use
Optogenetics/*methods
Trans-Activators/*radiation effects
Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cell Engineering ; Diabetes Mellitus, Type 2/genetics ; Female ; Genetic Engineering ; Glucagon-Like Peptide 1/genetics ; Glucagon-Like Peptide 1/metabolism ; HEK293 Cells ; Humans ; Light ; Male ; Mesenchymal Stem Cells ; Mice ; Mice, Obese ; Optogenetics/instrumentation ; Photoplethysmography/instrumentation ; Protein Domains/genetics ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Recombinant Fusion Proteins/radiation effects ; Thermus thermophilus/genetics ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Transgenes ; Wearable Electronic Devices
Czasopismo naukowe
Tytuł :
Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography.
Autorzy :
Manell E; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden .
Puuvuori E; Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Svensson A; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Velikyan I; Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Hulsart-Billström G; Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Hedenqvist P; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Holst JJ; NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jensen Waern M; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Eriksson O; Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
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Źródło :
BMJ open diabetes research & care [BMJ Open Diabetes Res Care] 2021 Apr; Vol. 9 (1).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2*/metabolism
Glucagon-Like Peptide 1*
Animals ; Autoradiography ; Gastrointestinal Tract/diagnostic imaging ; Pancreas/diagnostic imaging ; Pancreas/metabolism ; Swine ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model.
Autorzy :
Fang X; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China. Electronic address: .
Du Z; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Duan C; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Zhan S; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Wang T; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Zhu M; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Shi J; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Meng J; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Zhang X; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Yang M; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Zuo Y; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
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Źródło :
Life sciences [Life Sci] 2021 Apr 01; Vol. 270, pp. 118966. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus/*metabolism
Glucagon-Like Peptide 1/*analogs & derivatives
Hypoglycemic Agents/*pharmacology
Non-alcoholic Fatty Liver Disease/*drug therapy
Obesity/*metabolism
Peptide Fragments/*pharmacology
Animals ; Antioxidants/pharmacology ; Diabetes Complications/drug therapy ; Diabetes Mellitus/drug therapy ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide 1/pharmacology ; Hypoglycemic Agents/metabolism ; Insulin/metabolism ; Insulin Resistance ; Leptin/metabolism ; Liraglutide/pharmacology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Non-alcoholic Fatty Liver Disease/metabolism ; Obesity/complications ; Oxidation-Reduction ; PPAR alpha/metabolism ; Peptide Fragments/chemistry ; Weight Loss/drug effects
Czasopismo naukowe
Tytuł :
Combination of α-Glycosyl-Isoquercitrin and Soybean Fiber Promotes Quercetin Bioavailability and Glucagon-like Peptide-1 Secretion and Improves Glucose Homeostasis in Rats Fed a High-Fat High-Sucrose Diet.
Autorzy :
Trakooncharoenvit A; Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
Hara H; Department of Food Science and Human Nutrition, Fuji Women's University, Ishikari 061-3204, Japan.
Hira T; Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.; Research Faculty of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Jun 02; Vol. 69 (21), pp. 5907-5916. Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
Glucagon-Like Peptide 1*
Quercetin*/analogs & derivatives
Animals ; Biological Availability ; Blood Glucose ; Diet, High-Fat/adverse effects ; Homeostasis ; Insulin ; Rats ; Soybeans ; Sucrose
Czasopismo naukowe
Tytuł :
Engineered Bacteria of MG1363-pMG36e-GLP-1 Attenuated Obesity-Induced by High Fat Diet in Mice.
Autorzy :
Wang L; National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
Chen T; National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
Wang H; National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
Wu X; College of Basic Medicine, JiangXi University of Traditional Chinese Medicine, Nanchang, China.
Cao Q; National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
Wen K; National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
Deng KY; National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
Xin H; National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2021 Feb 25; Vol. 11, pp. 595575. Date of Electronic Publication: 2021 Feb 25 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diet, High-Fat*
Glucagon-Like Peptide 1*
Animals ; Bacteria/genetics ; Liver ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity
Czasopismo naukowe
Tytuł :
EGLP-1 lowers body weight better than exendin-4 by reducing food intake and increasing basal energy expenditure in diet-induced obese mice.
Autorzy :
Gao H; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China; School of Medicine, Henan Province Key Laboratory of Germplasm Innovation and Utilization of Eco-economic Woody Plant, Pingdingshan University, China.
Zhao Q; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China.
Li K; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China.
Qin F; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China.
Yin X; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China.
Lu Z; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China.
Song Z; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China.
Wu Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China.
Shen Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China.
Pan Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China.
Jin L; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China. Electronic address: .
Yanfeng Zhang; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Feb 01; Vol. 399 (1), pp. 112454. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Body Weight/*drug effects
Eating/*drug effects
Energy Metabolism/*drug effects
Glucagon-Like Peptide 1/*pharmacology
Obesity/*metabolism
Animals ; Anti-Obesity Agents/pharmacology ; Cells, Cultured ; Diet, High-Fat ; Eating/physiology ; Exenatide/pharmacology ; Exenatide/therapeutic use ; Glucagon-Like Peptide 1/chemistry ; Glucagon-Like Peptide 1/therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/drug therapy ; Obesity/etiology ; Peptide Fragments/pharmacology ; Peptide Fragments/therapeutic use
Czasopismo naukowe
Tytuł :
Display of quintuple glucagon-like peptide 1 (28-36) nonapeptide on Bacillus subtilis spore for oral administration in the treatment of type 2 diabetes.
Autorzy :
Kang M; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Feng F; School of Biological and Food Engineering, Suzhou University, Suzhou, Anhui, PR China.
Ge Q; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.; School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Zhu F; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Chen L; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Lv P; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Ma S; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Yao Q; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Chen K; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
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Źródło :
Journal of applied microbiology [J Appl Microbiol] 2021 Feb; Vol. 130 (2), pp. 314-324. Date of Electronic Publication: 2020 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Bacillus subtilis/*metabolism
Diabetes Mellitus, Type 2/*drug therapy
Glucagon-Like Peptide 1/*administration & dosage
Glucagon-Like Peptide 1/*metabolism
Incretins/*administration & dosage
Administration, Oral ; Animals ; Bacillus subtilis/genetics ; Blood Glucose/drug effects ; Cell Surface Display Techniques ; Diabetes Mellitus, Experimental ; Glucagon-Like Peptide 1/genetics ; Insulin/blood ; Male ; Mice ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Spores, Bacterial/genetics ; Spores, Bacterial/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Metabolic Messengers: glucagon-like peptide 1.
Autorzy :
Gribble FM; Wellcome Trust MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. .
Reimann F; Wellcome Trust MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. .
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Źródło :
Nature metabolism [Nat Metab] 2021 Feb; Vol. 3 (2), pp. 142-148. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Glucagon-Like Peptide 1/*metabolism
Animals ; Gastrointestinal Hormones/metabolism ; Glucagon-Like Peptide 1/drug effects ; Glucagon-Like Peptide 1/physiology ; Humans
Czasopismo naukowe
Tytuł :
Albumin-binding domain extends half-life of glucagon-like peptide-1.
Autorzy :
Tan H; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Su W; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Zhang W; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Zhang J; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Sattler M; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China; Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Center for Integrated Protein Science Munich at Chair Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany.
Zou P; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China; Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Center for Integrated Protein Science Munich at Chair Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Jan 05; Vol. 890, pp. 173650. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Obesity Agents/*pharmacokinetics
Glucagon-Like Peptide 1/*pharmacokinetics
Hypoglycemic Agents/*pharmacokinetics
Recombinant Fusion Proteins/*pharmacokinetics
Serum Albumin, Human/*metabolism
Animals ; Anti-Obesity Agents/chemistry ; Anti-Obesity Agents/pharmacology ; Blood Glucose/drug effects ; Diabetes Mellitus, Type 2/drug therapy ; Eating/drug effects ; Female ; Glucagon-Like Peptide 1/chemistry ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucose Tolerance Test ; Half-Life ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/pharmacology ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Protein Binding ; Protein Domains ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/pharmacology
Czasopismo naukowe
Tytuł :
Effects of GLP-1 and Its Analogs on Gastric Physiology in Diabetes Mellitus and Obesity.
Autorzy :
Maselli DB; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Camilleri M; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. .
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1307, pp. 171-192.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Diabetes Mellitus, Type 2*/drug therapy
Gastric Emptying*
Glucagon-Like Peptide 1*/agonists
Glucagon-Like Peptide 1*/analogs & derivatives
Obesity*/drug therapy
Blood Glucose ; Glucagon-Like Peptide-1 Receptor ; Humans ; Hypoglycemic Agents
Czasopismo naukowe
Tytuł :
Reduced postprandial bone resorption and greater rise in GLP-1 in overweight and obese individuals after an α-glucosidase inhibitor: a double-blinded randomized crossover trial.
Autorzy :
Kreitman A; Department of Nutritional Sciences, Rutgers University, 59 Dudley RD, New Brunswick, NJ, 08901, USA.
Schneider SH; Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, Rutgers-Robert Wood Johnson University Hospital, New Brunswick, NJ, 08901, USA.; NJ-Institute of Food, Nutrition and Health, New Brunswick, NJ, 08901, USA.
Hao L; Department of Nutritional Sciences, Rutgers University, 59 Dudley RD, New Brunswick, NJ, 08901, USA.; NJ-Institute of Food, Nutrition and Health, New Brunswick, NJ, 08901, USA.
Schlussel Y; Department of Nutritional Sciences, Rutgers University, 59 Dudley RD, New Brunswick, NJ, 08901, USA.
Bello NT; NJ-Institute of Food, Nutrition and Health, New Brunswick, NJ, 08901, USA.; Department of Animal Sciences, Rutgers University, New Brunswick, NJ, 08901, USA.
Shapses SA; Department of Nutritional Sciences, Rutgers University, 59 Dudley RD, New Brunswick, NJ, 08901, USA. .; Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, Rutgers-Robert Wood Johnson University Hospital, New Brunswick, NJ, 08901, USA. .; NJ-Institute of Food, Nutrition and Health, New Brunswick, NJ, 08901, USA. .
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Źródło :
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2021 Jul; Vol. 32 (7), pp. 1379-1386. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Bone Resorption*/drug therapy
Bone Resorption*/prevention & control
Glucagon-Like Peptide 1*
Adult ; Animals ; Blood Glucose ; Cross-Over Studies ; Double-Blind Method ; Glycoside Hydrolase Inhibitors ; Humans ; Insulin ; Obesity/drug therapy ; Overweight/drug therapy
Czasopismo naukowe
Tytuł :
Glucagon-like peptide-1 response to whey protein is less diminished by dipeptidyl peptidase-4 in comparison with responses to dextrin, a lipid and casein in rats.
Autorzy :
Shimizu Y; Graduate School of Agriculture, Hokkaido University, Sapporo060-8589, Japan.
Hara H; Faculty of Human Life Science, Fuji Women's University, Ishikari061-3204, Japan.
Hira T; Graduate School of Agriculture, Hokkaido University, Sapporo060-8589, Japan.; Research Faculty of Agriculture, Hokkaido University, Sapporo060-8589, Japan.
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Źródło :
The British journal of nutrition [Br J Nutr] 2021 Feb 28; Vol. 125 (4), pp. 398-407. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dextrins/*pharmacology
Dipeptidyl Peptidase 4/*metabolism
Glucagon-Like Peptide 1/*metabolism
Lipids/*pharmacology
Whey Proteins/*pharmacology
Animal Feed ; Animals ; Animals, Genetically Modified ; Caseins/administration & dosage ; Caseins/pharmacology ; Diet ; Dietary Proteins/administration & dosage ; Dipeptidyl Peptidase 4/genetics ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Gene Expression Regulation/drug effects ; Glucagon-Like Peptide 1/genetics ; Lipids/administration & dosage ; Rats ; Rats, Sprague-Dawley ; Sitagliptin Phosphate/pharmacology
Czasopismo naukowe
Tytuł :
Expression of a novel dual-functional polypeptide and its pharmacological action research.
Autorzy :
Li X; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China; School of Mental Health, Jining Medical University, Jining, Shandong 272067, China.
Yang X; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Umar M; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Zhang Z; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Luo W; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Fan Y; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Ma D; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Li M; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 15; Vol. 267, pp. 118890. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article
MeSH Terms :
Glucagon-Like Peptide 1/*pharmacology
Hypoglycemia/*drug therapy
Subtilisins/*pharmacology
Animals ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Disease Models, Animal ; Glucagon-Like Peptide 1/metabolism ; Hypoglycemia/metabolism ; Insulin/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Peptides/metabolism ; Peptides/pharmacology ; Subtilisins/metabolism ; Thrombosis/drug therapy ; Thrombosis/metabolism
Czasopismo naukowe
Tytuł :
Effects of a glucagon-like peptide-1 analog on appetitive and consummatory behavior for rewarding and aversive gustatory stimuli in rats.
Autorzy :
Douton JE; Department of Neural and Behavioral Sciences, Penn State College of Medicine, 500 University Drive, H181, Hershey, PA 17033. Electronic address: .
Norgren R; Department of Neural and Behavioral Sciences, Penn State College of Medicine, 500 University Drive, H181, Hershey, PA 17033. Electronic address: .
Grigson PS; Department of Neural and Behavioral Sciences, Penn State College of Medicine, 500 University Drive, H181, Hershey, PA 17033. Electronic address: .
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Źródło :
Physiology & behavior [Physiol Behav] 2021 Feb 01; Vol. 229, pp. 113279. Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2*
Glucagon-Like Peptide 1*
Animals ; Appetitive Behavior ; Consummatory Behavior ; Rats ; Reward ; Taste
Czasopismo naukowe
Tytuł :
Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells.
Autorzy :
Ribeiro-Parenti L; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Service de Chirurgie Générale Œsogastrique et Bariatrique, Hôpital Bichat - Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France.
Jarry AC; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.
Cavin JB; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.
Willemetz A; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.
Le Beyec J; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Sorbonne Université, AP-HP, Hôpital Pitié-Salpêtrière-Charles Foix, Biochimie Endocrinienne et Oncologique, Paris, France.
Sannier A; Department of Pathology Bichat Hospital, AP-HP, 75018, Paris, France.
Benadda S; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Cell and Tissue Imaging Platform, Inserm, U1149, CNRS, ERL8252, 75018, Paris, France.
Pelletier AL; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.
Hourseau M; Department of Pathology Bichat Hospital, AP-HP, 75018, Paris, France.
Léger T; Université de Paris, Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, CNRS, 75205, Paris, France.; Université Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, 35000, Rennes, France.
Morlet B; Université de Paris, Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, CNRS, 75205, Paris, France.
Couvelard A; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Department of Pathology Bichat Hospital, AP-HP, 75018, Paris, France.
Anini Y; Department of Obstetrics and Gynecology, Dalhousie University, IWK Health Centre, Halifax, New Brunswick, Canada.
Msika S; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Service de Chirurgie Générale Œsogastrique et Bariatrique, Hôpital Bichat - Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France.
Marmuse JP; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Service de Chirurgie Générale Œsogastrique et Bariatrique, Hôpital Bichat - Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France.
Ledoux S; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Service des Explorations Fonctionnelles Hôpital Louis Mourier, AP-HP, Centre Intégré Nord Francilien de prise en charge de l'Obésité (CINFO), 92701, Colombes, France.
Le Gall M; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France. .
Bado A; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 110. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bariatric Surgery*
Gastric Mucosa/*metabolism
Gastric Mucosa/*pathology
Glucagon-Like Peptide 1/*metabolism
1-Methyl-3-isobutylxanthine/pharmacology ; Adult ; Amino Acid Sequence ; Animals ; Diet, High-Fat ; Female ; Glucagon-Like Peptide 1/chemistry ; Glucose/metabolism ; Humans ; Male ; Middle Aged ; Obesity/pathology ; Phenotype ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes.
Autorzy :
Grespan E; Institute of Neuroscience, National Research Council, Padua 35127, Italy.
Giorgino T; Biophysics Institute, National Research Council, Milan 20133, Italy; Department of Biosciences, University of Milan, Milan 20133, Italy.
Natali A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa 56126, Italy.
Ferrannini E; Institute of Clinical Physiology, National Research Council, Pisa 56124, Italy.
Mari A; Institute of Neuroscience, National Research Council, Padua 35127, Italy. Electronic address: .
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Źródło :
Metabolism: clinical and experimental [Metabolism] 2021 Jan; Vol. 114, pp. 154415. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Gastric Inhibitory Polypeptide/*administration & dosage
Glucagon-Like Peptide 1/*administration & dosage
Incretins/*administration & dosage
Insulin Secretion/*drug effects
Insulin-Secreting Cells/*drug effects
Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Gastric Inhibitory Polypeptide/therapeutic use ; Glucagon-Like Peptide 1/therapeutic use ; Glucose Tolerance Test ; Humans ; Incretins/therapeutic use ; Insulin-Secreting Cells/metabolism ; Models, Theoretical
Czasopismo naukowe
Tytuł :
Glucagon-like peptide-1 cleavage product GLP-1(9-36) reduces neuroinflammation from stroke via the activation of insulin-like growth factor 1 receptor in astrocytes.
Autorzy :
Huang J; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Xi'an, China; Department of Neurology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Liu Y; Department of Neurology Impatient, Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Cheng L; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Xi'an, China.
Li J; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Xi'an, China.
Zhang T; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Xi'an, China.
Zhao G; Department of Neurology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Zhang H; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Xi'an, China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Nov 15; Vol. 887, pp. 173581. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
Astrocytes/*drug effects
Encephalitis/*drug therapy
Encephalitis/*etiology
Glucagon-Like Peptide 1/*analogs & derivatives
Glucagon-Like Peptide 1/*metabolism
Receptor, IGF Type 1/*agonists
Stroke/*complications
Stroke/*drug therapy
Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Behavior, Animal/drug effects ; Cell Hypoxia ; Cytokines/metabolism ; Encephalitis/psychology ; Gene Knockdown Techniques ; Glucagon-Like Peptide 1/genetics ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide 1/therapeutic use ; Glucose/deficiency ; Mice ; Mice, Knockout ; Primary Cell Culture ; Receptor, IGF Type 1/genetics ; Signal Transduction/drug effects ; Stroke/psychology
Czasopismo naukowe
Tytuł :
Stapled and Xenopus Glucagon-Like Peptide 1 (GLP-1)-Based Dual GLP-1/Gastrin Receptor Agonists with Improved Metabolic Benefits in Rodent Models of Obesity and Diabetes.
Autorzy :
Chen X; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Fu J; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China.
Zhou F; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Yang Q; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Wang J; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Feng H; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Jiang W; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Jin L; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Tang X; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Jiang N; Department of Pharmacy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, PR China.
Yin J; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China.
Han J; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12595-12613. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon-Like Peptide 1/*agonists
Hypoglycemic Agents/*chemistry
Receptor, Cholecystokinin B/*agonists
Xenopus Proteins/*agonists
Xenopus laevis/*metabolism
Animals ; Body Weight/drug effects ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/pathology ; Disease Models, Animal ; Glucagon-Like Peptide 1/genetics ; Glucagon-Like Peptide 1/metabolism ; Glucose Tolerance Test ; Half-Life ; Hypoglycemic Agents/metabolism ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Insulin-Secreting Cells/cytology ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mutagenesis, Site-Directed ; Obesity/metabolism ; Obesity/pathology ; Peptides/chemical synthesis ; Peptides/chemistry ; Peptides/metabolism ; Peptides/pharmacology ; Peptides/therapeutic use ; Receptor, Cholecystokinin B/metabolism ; Structure-Activity Relationship ; Xenopus Proteins/genetics ; Xenopus Proteins/metabolism
Czasopismo naukowe
Tytuł :
Circadian GLP-1 Secretion in Mice Is Dependent on the Intestinal Microbiome for Maintenance of Diurnal Metabolic Homeostasis.
Autorzy :
Martchenko SE; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Martchenko A; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Cox BJ; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
Naismith K; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Waller A; Department of Biological Sciences, Brock University, St. Catharines, Ontario, Canada.
Gurges P; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Sweeney ME; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Philpott DJ; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Brubaker PL; Department of Physiology, University of Toronto, Toronto, Ontario, Canada .; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
Diabetes [Diabetes] 2020 Dec; Vol. 69 (12), pp. 2589-2602. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Circadian Rhythm*
Gastrointestinal Microbiome*
Homeostasis*
Glucagon-Like Peptide 1/*metabolism
Animals ; Dietary Carbohydrates/administration & dosage ; Dietary Fats/administration & dosage ; Female ; Gene Expression Regulation/drug effects ; Glucagon-Like Peptide 1/genetics ; Glucose/administration & dosage ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/metabolism ; Sucrose
Czasopismo naukowe
Tytuł :
Glucagon-like peptide-1 alleviates diabetic kidney disease through activation of autophagy by regulating AMP-activated protein kinase-mammalian target of rapamycin pathway.
Autorzy :
Yang S; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.; Department of Endocrinology, Second Affiliated Hospital of Guizhou Medical University, Kaili, Guizhou, China.
Lin C; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Zhuo X; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Wang J; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Rao S; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
Xu W; Laboratory of Diabetology, Department of Endocrinology and Metabolism, Guangdong Provincial Key Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Cheng Y; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Yang L; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2020 Dec 01; Vol. 319 (6), pp. E1019-E1030. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy/*drug effects
Diabetes Mellitus, Experimental/*drug therapy
Diabetic Nephropathies/*prevention & control
Glucagon-Like Peptide 1/*therapeutic use
AMP-Activated Protein Kinases/metabolism ; Animals ; Cells, Cultured ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Exenatide/pharmacology ; Exenatide/therapeutic use ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide-1 Receptor/agonists ; HEK293 Cells ; Humans ; Rats ; Rats, Zucker ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe

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