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Wyszukujesz frazę ""Gluconeogenesis"" wg kryterium: Temat


Tytuł :
Tracking the carbons supplying gluconeogenesis.
Autorzy :
Shah AM; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA.
Wondisford FE; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Oct 16; Vol. 295 (42), pp. 14419-14429. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Gluconeogenesis*
Carbon/*metabolism
Diabetes Mellitus, Type 2/*pathology
Animals ; Carbon Isotopes/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Glucose/metabolism ; Glycogen/metabolism ; Humans ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Metabolomics
Czasopismo naukowe
Tytuł :
Reply to Mishra: Prohibitin heterodimers-a complex time dependence for carcinogenesis.
Autorzy :
Martin-Levilain J; Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1206 Geneva, Switzerland.; Faculty Diabetes Centre, University of Geneva Medical Centre, 1206 Geneva, Switzerland.
Li L; Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1206 Geneva, Switzerland.; Faculty Diabetes Centre, University of Geneva Medical Centre, 1206 Geneva, Switzerland.
Maechler P; Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1206 Geneva, Switzerland .; Faculty Diabetes Centre, University of Geneva Medical Centre, 1206 Geneva, Switzerland.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Oct 04; Vol. 294 (40), pp. 14837.
Typ publikacji :
Letter; Comment
MeSH Terms :
Gluconeogenesis*
Repressor Proteins*
Carcinogenesis ; GTP Phosphohydrolases ; Hepatocytes ; Humans
Opinia redakcyjna
Tytuł :
Phb1:Phb2 heterodimers in the mitochondria-beyond functional interdependence.
Autorzy :
Mishra S; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba R3E 3P4, Canada .; Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba R3E 3P4, Canada.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Oct 04; Vol. 294 (40), pp. 14836.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Gluconeogenesis*
Mitochondria*
Hepatocytes ; Repressor Proteins
Raport
Tytuł :
In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way.
Autorzy :
Li L; Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1206 Geneva, Switzerland.; Faculty Diabetes Centre, University of Geneva Medical Centre, 1206 Geneva, Switzerland.
Martin-Levilain J; Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1206 Geneva, Switzerland.; Faculty Diabetes Centre, University of Geneva Medical Centre, 1206 Geneva, Switzerland.
Jiménez-Sánchez C; Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1206 Geneva, Switzerland.; Faculty Diabetes Centre, University of Geneva Medical Centre, 1206 Geneva, Switzerland.
Karaca M; Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1206 Geneva, Switzerland.; Faculty Diabetes Centre, University of Geneva Medical Centre, 1206 Geneva, Switzerland.
Foti M; Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1206 Geneva, Switzerland.; Faculty Diabetes Centre, University of Geneva Medical Centre, 1206 Geneva, Switzerland.
Martinou JC; Cell Biology Department, Faculty of Sciences, University of Geneva, 1205 Geneva, Switzerland.
Maechler P; Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1206 Geneva, Switzerland .; Faculty Diabetes Centre, University of Geneva Medical Centre, 1206 Geneva, Switzerland.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Aug 23; Vol. 294 (34), pp. 12581-12598. Date of Electronic Publication: 2019 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gluconeogenesis*
GTP Phosphohydrolases/*metabolism
Hepatocytes/*metabolism
Mitochondria/*metabolism
Repressor Proteins/*metabolism
Animals ; Apoptosis ; Cell Respiration ; Hepatocytes/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Repressor Proteins/deficiency
Czasopismo naukowe
Tytuł :
Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction.
Autorzy :
Banerjee S; Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Ghoshal S; Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Stevens JR; Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
McCommis KS; Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, USA; Center for Cardiovascular Research, Saint Louis University School of Medicine, St. Louis, Missouri, USA; Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, Missouri USA.
Gao S; Department of Metabolism and Aging, Scripps Research Institute, Jupiter, Florida, USA.
Castro-Sepulveda M; Laboratorio de Ciencias del Ejercicio. Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile.
Mizgier ML; Departamento de Ciencias de la SaludCarrera de Nutrición y Dietética and Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Girardet C; Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Kumar KG; Department of Metabolism and Aging, Scripps Research Institute, Jupiter, Florida, USA.
Galgani JE; Departamento de Ciencias de la SaludCarrera de Nutrición y Dietética and Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Niehoff ML; Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri, USA; Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, Saint Louis University School of Medicine; Research Service, John Cochran Division, Saint Louis Veterans Affairs Medical Center, Missouri, USA.
Farr SA; Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri, USA; Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, Saint Louis University School of Medicine; Research Service, John Cochran Division, Saint Louis Veterans Affairs Medical Center, Missouri, USA.
Zhang J; Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Butler AA; Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA; Department of Metabolism and Aging, Scripps Research Institute, Jupiter, Florida, USA; Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Oct 02; Vol. 295 (40), pp. 13753-13768. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Caloric Restriction*
Fasting*
Gene Expression Regulation*
Hepatocytes/*metabolism
Intercellular Signaling Peptides and Proteins/*biosynthesis
Liver/*metabolism
Animals ; Cyclic AMP-Dependent Protein Kinases/genetics ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Gluconeogenesis/genetics ; Hepatocytes/cytology ; Intercellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/biosynthesis ; Intracellular Signaling Peptides and Proteins/genetics ; Liver/cytology ; Mice ; Mice, Knockout ; Phosphoenolpyruvate Carboxykinase (GTP)/biosynthesis ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa .
Autorzy :
Crousilles A; From the Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, United Kingdom.
Dolan SK; From the Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, United Kingdom.
Brear P; From the Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, United Kingdom.
Chirgadze DY; From the Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, United Kingdom.
Welch M; From the Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, United Kingdom .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 Sep 14; Vol. 293 (37), pp. 14260-14269. Date of Electronic Publication: 2018 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gluconeogenesis*
Glyoxylates/*metabolism
Isocitrate Lyase/*metabolism
Pseudomonas aeruginosa/*metabolism
Acetyl Coenzyme A/metabolism ; Citric Acid Cycle ; Crystallography, X-Ray ; Decarboxylation ; Escherichia coli/metabolism ; Isocitrate Dehydrogenase/antagonists & inhibitors ; Isocitrate Dehydrogenase/chemistry ; Isocitrate Dehydrogenase/metabolism ; Isocitrate Lyase/antagonists & inhibitors ; Isocitrate Lyase/chemistry ; Kinetics ; Oxaloacetic Acid/metabolism ; Phosphorylation ; Pseudomonas aeruginosa/enzymology
Czasopismo naukowe
Tytuł :
The SMILE transcriptional corepressor inhibits cAMP response element-binding protein (CREB)-mediated transactivation of gluconeogenic genes.
Autorzy :
Lee JM; From the National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, Republic of Korea.
Han HS; Division of Life Sciences, College of Life Sciences and Biotechnology, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul 136-713, Republic of Korea, and.
Jung YS; From the National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, Republic of Korea.
Harris RA; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160.
Koo SH; Division of Life Sciences, College of Life Sciences and Biotechnology, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul 136-713, Republic of Korea, and .
Choi HS; From the National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, Republic of Korea, .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 Aug 24; Vol. 293 (34), pp. 13125-13133. Date of Electronic Publication: 2018 Jun 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gluconeogenesis*
Transcriptional Activation*
Basic-Leucine Zipper Transcription Factors/*metabolism
Cyclic AMP Response Element-Binding Protein/*metabolism
Glucose-6-Phosphatase/*metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*metabolism
Transcription Factors/*metabolism
Animals ; Basic-Leucine Zipper Transcription Factors/genetics ; Cyclic AMP Response Element-Binding Protein/genetics ; Gene Expression Regulation ; Glucose-6-Phosphatase/genetics ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Phosphoenolpyruvate Carboxylase/genetics ; Promoter Regions, Genetic ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Glycine N -methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates.
Autorzy :
Hughey CC; From the Department of Molecular Physiology and Biophysics and .
Trefts E; From the Department of Molecular Physiology and Biophysics and.
Bracy DP; From the Department of Molecular Physiology and Biophysics and.; the Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, Tennessee 37232.
James FD; From the Department of Molecular Physiology and Biophysics and.; the Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, Tennessee 37232.
Donahue EP; From the Department of Molecular Physiology and Biophysics and.
Wasserman DH; From the Department of Molecular Physiology and Biophysics and.; the Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, Tennessee 37232.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 Jul 27; Vol. 293 (30), pp. 11944-11954. Date of Electronic Publication: 2018 Jun 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Deletion*
Gluconeogenesis*
Carbon/*metabolism
Glycine N-Methyltransferase/*genetics
Methionine/*metabolism
Animals ; Citric Acid Cycle ; Energy Metabolism ; Fatty Liver/genetics ; Fatty Liver/metabolism ; Glucose/metabolism ; Glycine N-Methyltransferase/metabolism ; Liver/metabolism ; Male ; Metabolic Flux Analysis ; Mice ; Mice, Knockout ; S-Adenosylmethionine/metabolism
Czasopismo naukowe
Tytuł :
Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice.
Autorzy :
Zhang Y; From the Molecular Medicine Research Center, West China Hospital, State Key Laboratory of Biotherapy, Sichuan University and Collaborative Innovation Center, Chengdu 610041, Sichuan, China.
Guan Q; the Department of Geriatrics, People's Hospital of Sichuan Province, Chengdu 610041, Sichuan, China, and.
Liu Y; From the Molecular Medicine Research Center, West China Hospital, State Key Laboratory of Biotherapy, Sichuan University and Collaborative Innovation Center, Chengdu 610041, Sichuan, China.
Zhang Y; the Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
Chen Y; From the Molecular Medicine Research Center, West China Hospital, State Key Laboratory of Biotherapy, Sichuan University and Collaborative Innovation Center, Chengdu 610041, Sichuan, China.
Chen J; From the Molecular Medicine Research Center, West China Hospital, State Key Laboratory of Biotherapy, Sichuan University and Collaborative Innovation Center, Chengdu 610041, Sichuan, China.
Liu Y; From the Molecular Medicine Research Center, West China Hospital, State Key Laboratory of Biotherapy, Sichuan University and Collaborative Innovation Center, Chengdu 610041, Sichuan, China.
Su Z; From the Molecular Medicine Research Center, West China Hospital, State Key Laboratory of Biotherapy, Sichuan University and Collaborative Innovation Center, Chengdu 610041, Sichuan, China, .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 May 18; Vol. 293 (20), pp. 7894-7904. Date of Electronic Publication: 2018 Mar 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CCAAT-Binding Factor/*genetics
Gluconeogenesis/*genetics
Glucose/*metabolism
Glucose-6-Phosphatase/*genetics
Hepatocytes/*metabolism
Liver/*metabolism
Phosphoenolpyruvate Carboxykinase (GTP)/*genetics
Animals ; Binding Sites ; CCAAT-Binding Factor/deficiency ; CREB-Binding Protein/genetics ; CREB-Binding Protein/metabolism ; CRISPR-Cas Systems ; Cell Line ; Cyclic AMP/pharmacology ; Fasting/metabolism ; Gene Deletion ; Gene Expression Regulation ; Glucagon/pharmacology ; Gluconeogenesis/drug effects ; Glucose-6-Phosphatase/metabolism ; Hepatocytes/cytology ; Hepatocytes/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism ; Primary Cell Culture ; Promoter Regions, Genetic ; Protein Binding ; Signal Transduction
Czasopismo naukowe
Tytuł :
The long non-coding RNA Gm10768 activates hepatic gluconeogenesis by sequestering microRNA-214 in mice.
Autorzy :
Cui X; From the Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023.; the Nanjing Maternal and Child Health Medical Institute, Nanjing Maternal and Child Health Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004.
Tan J; From the Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023.
Shi Y; From the Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023.
Sun C; From the Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023.
Li Y; the Nanjing Maternal and Child Health Medical Institute, Nanjing Maternal and Child Health Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004.
Ji C; the Nanjing Maternal and Child Health Medical Institute, Nanjing Maternal and Child Health Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004.
Wu J; the Department of Geriatric Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, and.
Zhang Z; From the Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023.
Chen S; the School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu 211198, China .
Guo X; the Nanjing Maternal and Child Health Medical Institute, Nanjing Maternal and Child Health Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004, .
Liu C; From the Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, .; the School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 Mar 16; Vol. 293 (11), pp. 4097-4109. Date of Electronic Publication: 2018 Jan 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gluconeogenesis*
Diabetes Mellitus, Type 2/*genetics
Hepatocytes/*metabolism
Hyperglycemia/*genetics
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
Animals ; Cells, Cultured ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Gene Expression Regulation ; Hepatocytes/pathology ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
Managing the sugar factory: A new feather in the cap for nuclear factor Y.
Autorzy :
Sen S; From the Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.
Das C; From the Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 May 18; Vol. 293 (20), pp. 7905-7906.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Gluconeogenesis*
Transcription Factors*
Animals ; CCAAT-Binding Factor ; Feathers ; Glucose ; Hepatocytes ; Liver ; Mice ; Sugars
Czasopismo naukowe
Tytuł :
The KLF14 transcription factor regulates hepatic gluconeogenesis in mice.
Autorzy :
Wang L; From the Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei 230032.
Tong X; From the Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei 230032.
Gu F; From the Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei 230032.
Zhang L; the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Science, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100005.
Chen W; the Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032.
Cheng X; the Department of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, and.
Xie L; the State Key Laboratory of Applied Microbiology in Southern China, Guangdong Institute of Microbiology, Guangzhou 510070, China .
Chang Y; the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Science, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100005, .
Zhang H; From the Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei 230032, .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2017 Dec 29; Vol. 292 (52), pp. 21631-21642. Date of Electronic Publication: 2017 Nov 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gluconeogenesis/*physiology
Kruppel-Like Transcription Factors/*metabolism
Liver/*metabolism
Animals ; Diabetes Mellitus, Type 2/metabolism ; Diet, High-Fat ; Gluconeogenesis/genetics ; Glucose/metabolism ; Glucose Intolerance/metabolism ; Hepatocytes/metabolism ; Insulin Resistance/physiology ; Kruppel-Like Transcription Factors/physiology ; Mice ; Mice, Inbred C57BL ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
Czasopismo naukowe
Tytuł :
Transcription factor 19 interacts with histone 3 lysine 4 trimethylation and controls gluconeogenesis via the nucleosome-remodeling-deacetylase complex.
Autorzy :
Sen S; From the Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata-700064 and.
Sanyal S; From the Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata-700064 and.
Srivastava DK; the Structural Biology and Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata-700032, India.
Dasgupta D; From the Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata-700064 and.
Roy S; the Structural Biology and Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata-700032, India.
Das C; From the Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata-700064 and .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2017 Dec 15; Vol. 292 (50), pp. 20362-20378. Date of Electronic Publication: 2017 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gluconeogenesis*
Models, Molecular*
Protein Processing, Post-Translational*
Hepatocytes/*metabolism
Histones/*metabolism
Mi-2 Nucleosome Remodeling and Deacetylase Complex/*metabolism
Transcription Factors/*metabolism
Cell Line ; Epigenesis, Genetic ; Gene Expression Regulation, Enzymologic ; Hepatocytes/cytology ; Hepatocytes/enzymology ; Histones/chemistry ; Histones/genetics ; Humans ; Lysine ; Methylation ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/chemistry ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Mutation ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Promoter Regions, Genetic ; Protein Conformation ; Protein Interaction Domains and Motifs ; Protein Transport ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Transcription Factors/chemistry ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase.
Autorzy :
Dong S; From the Department of Biochemistry and Molecular Biology, School of Medicine, and.
Baranwal S; From the Department of Biochemistry and Molecular Biology, School of Medicine, and.; the Center for Biochemistry and Microbial Sciences, Central University of Punjab, City Campus Mansa Rd., Bathinda-151001, India.
Garcia A; the Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322.
Serrano-Gomez SJ; From the Department of Biochemistry and Molecular Biology, School of Medicine, and.; the Pontificia Universidad Javeriana, 11001000 Bogotá, Colombia.
Eastlack S; From the Department of Biochemistry and Molecular Biology, School of Medicine, and.
Iwakuma T; the Department of Cancer Biology, Kansas University Medical Center, Kansas City, Kansas 66160, and.
Mercante D; Department of Biostatistics, School of Public Health, Louisiana State University Health Science Center, New Orleans, Louisiana 70112.
Mauvais-Jarvis F; the Division of Endocrinology, Tulane University School of Medicine, New Orleans, Louisiana 70112.
Alahari SK; From the Department of Biochemistry and Molecular Biology, School of Medicine, and .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2017 Oct 13; Vol. 292 (41), pp. 16833-16846. Date of Electronic Publication: 2017 Aug 24.
Typ publikacji :
Journal Article
MeSH Terms :
Energy Metabolism*
Gluconeogenesis*
Lipid Metabolism*
AMP-Activated Protein Kinases/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Liver/*metabolism
AMP-Activated Protein Kinases/genetics ; Animals ; Cell Line ; Glucose/genetics ; Glucose/metabolism ; Humans ; Imidazoline Receptors ; Intracellular Signaling Peptides and Proteins/genetics ; Liver/pathology ; Mice ; Mice, Mutant Strains ; Mutation ; Oxidation-Reduction ; Protein Binding
Czasopismo naukowe
Tytuł :
TGF-β1/Smad3 Pathway Targets PP2A-AMPK-FoxO1 Signaling to Regulate Hepatic Gluconeogenesis.
Autorzy :
Yadav H; Diabetes, Endocrinology, and Obesity Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20854.
Devalaraja S; Diabetes, Endocrinology, and Obesity Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20854.
Chung ST; Diabetes, Endocrinology, and Obesity Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20854.
Rane SG; Diabetes, Endocrinology, and Obesity Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20854. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2017 Feb 24; Vol. 292 (8), pp. 3420-3432. Date of Electronic Publication: 2017 Jan 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Gluconeogenesis*
Signal Transduction*
Liver/*metabolism
Smad3 Protein/*metabolism
Transforming Growth Factor beta1/*metabolism
AMP-Activated Protein Kinases/metabolism ; Animals ; Diabetes Mellitus, Type 2/metabolism ; Female ; Forkhead Box Protein O1/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Protein Phosphatase 2/metabolism
Czasopismo naukowe
Tytuł :
Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation.
Autorzy :
Moonira T; Biosciences Institute, Newcastle University, Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.
Chachra SS; Biosciences Institute, Newcastle University, Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.
Ford BE; Biosciences Institute, Newcastle University, Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.
Marin S; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, 08007 Barcelona, Spain; CIBEREHD and Metabolomics Node at INB-Bioinformatics Platform, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Alshawi A; Biosciences Institute, Newcastle University, Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.
Adam-Primus NS; Biosciences Institute, Newcastle University, Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.
Arden C; Biosciences Institute, Newcastle University, Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.
Al-Oanzi ZH; Biosciences Institute, Newcastle University, Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.
Foretz M; INSERM, U1016, Institut Cochin, Paris 75014, France; CNRS, UMR8104, Paris 75014, France; Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France.
Viollet B; INSERM, U1016, Institut Cochin, Paris 75014, France; CNRS, UMR8104, Paris 75014, France; Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France.
Cascante M; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, 08007 Barcelona, Spain; CIBEREHD and Metabolomics Node at INB-Bioinformatics Platform, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Agius L; Biosciences Institute, Newcastle University, Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Mar 06; Vol. 295 (10), pp. 3330-3346. Date of Electronic Publication: 2020 Jan 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucose/*metabolism
Glucose-6-Phosphate/*metabolism
Glycolysis/*drug effects
Metformin/*pharmacology
AMP-Activated Protein Kinases/deficiency ; AMP-Activated Protein Kinases/genetics ; Adenosine Triphosphate/metabolism ; Animals ; Dihydroxyacetone/pharmacology ; Gluconeogenesis/drug effects ; Glucose/pharmacology ; Glycerolphosphate Dehydrogenase/genetics ; Glycerolphosphate Dehydrogenase/metabolism ; Hepatocytes/cytology ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Male ; Metformin/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphofructokinase-1/antagonists & inhibitors ; Phosphofructokinase-1/metabolism ; Phosphorylation/drug effects ; Rats ; Rats, Wistar ; Rotenone/pharmacology
Czasopismo naukowe
Tytuł :
Glycerol induces G6pc in primary mouse hepatocytes and is the preferred substrate for gluconeogenesis both in vitro and in vivo .
Autorzy :
Kalemba KM; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey 08901.
Wang Y; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey 08901.
Xu H; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey 08901.
Chiles E; Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey 08903.
McMillin SM; Fred Wilson School of Pharmacy, High Point University, High Point, North Carolina.
Kwon H; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey 08901.
Su X; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey 08901; Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey 08903.
Wondisford FE; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey 08901; Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey 08903. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Nov 29; Vol. 294 (48), pp. 18017-18028. Date of Electronic Publication: 2019 Oct 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gluconeogenesis/*drug effects
Glucose-6-Phosphatase/*biosynthesis
Glycerol/*pharmacology
Hepatocytes/*metabolism
Animals ; Enzyme Induction/drug effects ; Hepatocytes/cytology ; Lactic Acid/metabolism ; Mice ; Pyruvic Acid/metabolism
Czasopismo naukowe
Tytuł :
The E3 ubiquitin ligase Pib1 regulates effective gluconeogenic shutdown upon glucose availability.
Autorzy :
Vengayil V; Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Post, Bellary Road, Bangalore 560065, India.; Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Rashida Z; Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Post, Bellary Road, Bangalore 560065, India.; Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Laxman S; Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Post, Bellary Road, Bangalore 560065, India .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Nov 15; Vol. 294 (46), pp. 17209-17223. Date of Electronic Publication: 2019 Oct 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucose/*metabolism
Saccharomyces cerevisiae Proteins/*genetics
Transcription Factors/*genetics
Ubiquitin-Protein Ligase Complexes/*genetics
Ubiquitin-Protein Ligases/*genetics
Gluconeogenesis/genetics ; Glucose/genetics ; Phosphorylation/genetics ; Proteasome Endopeptidase Complex/genetics ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae Proteins/metabolism ; Transcription Factors/metabolism ; Ubiquitin/genetics ; Ubiquitin-Protein Ligase Complexes/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination/genetics
Czasopismo naukowe
Tytuł :
The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.
Autorzy :
Tavares CD; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Sharabi K; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Dominy JE; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Lee Y; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Isasa M; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Orozco JM; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Jedrychowski MP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Kamenecka TM; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458.
Griffin PR; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458.
Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Puigserver P; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2016 May 13; Vol. 291 (20), pp. 10635-45. Date of Electronic Publication: 2016 Mar 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic/*drug effects
Gluconeogenesis/*drug effects
Histone Acetyltransferases/*biosynthesis
Liver/*metabolism
Methionine/*pharmacology
Transcription Factors/*metabolism
p300-CBP Transcription Factors/*biosynthesis
Acetylation/drug effects ; Animals ; Gluconeogenesis/genetics ; Hep G2 Cells ; Histone Acetyltransferases/genetics ; Humans ; Mice ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Transcription Factors/genetics ; p300-CBP Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Forkhead Box P1 (FOXP1) Transcription Factor Regulates Hepatic Glucose Homeostasis.
Autorzy :
Zou Y; From the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and.
Gong N; From the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and.
Cui Y; From the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and.
Wang X; From the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and.
Cui A; From the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and.
Chen Q; From the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and.
Jiao T; From the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and.
Dong X; From the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and.
Yang H; From the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and.
Zhang S; the Beijing Friendship Hospital Affiliated to the Capital Medical University, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing Digestive Disease Center, Beijing, China.
Fang F; From the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and.
Chang Y; From the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2015 Dec 18; Vol. 290 (51), pp. 30607-15. Date of Electronic Publication: 2015 Oct 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gluconeogenesis*
Homeostasis*
Forkhead Transcription Factors/*metabolism
Glucose/*metabolism
Liver/*metabolism
Repressor Proteins/*metabolism
Animals ; Diabetes Mellitus/genetics ; Diabetes Mellitus/metabolism ; Dietary Fats/adverse effects ; Dietary Fats/pharmacology ; Forkhead Transcription Factors/genetics ; Glucose/genetics ; Male ; Mice ; Mice, Obese ; Obesity/chemically induced ; Obesity/genetics ; Obesity/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Phosphoenolpyruvate Carboxykinase (GTP) ; Repressor Proteins/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe

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