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Wyszukujesz frazę ""Glutamate Dehydrogenase"" wg kryterium: Temat


Tytuł :
Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons.
Autorzy :
Traube FR; Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Özdemir D; Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Sahin H; Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Scheel C; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.
Glück AF; Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Geserich AS; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.
Oganesian S; Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Kostidis S; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, The Netherlands.
Iwan K; Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Rahimoff R; Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Giorgio G; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.
Müller M; Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Spada F; Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Biel M; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.
Cox J; Computational Systems Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany.
Giera M; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, The Netherlands.
Michalakis S; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany. .; Department of Ophthalmology, University Hospital, LMU Munich, Munich, Germany. .
Carell T; Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 02; Vol. 12 (1), pp. 4100. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Nucleus/*enzymology
Cell Nucleus/*metabolism
Dioxygenases/*metabolism
Glutamate Dehydrogenase/*metabolism
Ketoglutaric Acids/*metabolism
Neurons/*metabolism
Animals ; Brain/metabolism ; Citric Acid Cycle ; Dioxygenases/genetics ; Epigenomics ; Gene Expression ; Glutamate Dehydrogenase/genetics ; Glutamic Acid/metabolism ; HEK293 Cells ; Humans ; Ketoglutarate Dehydrogenase Complex/metabolism ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism ; Neuronal Plasticity
Czasopismo naukowe
Tytuł :
Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology.
Autorzy :
Dimovasili C; Neurology Laboratory, Medical School, University of Crete, Heraklion, Crete, Greece.; Departments of Psychiatry and Neuroscience, Center for Molecular Biology and Genetics of Neurodegeneration, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fadouloglou VE; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.; Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
Kefala A; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.; Department of Biology, University of Crete, Heraklion, Crete, Greece.
Providaki M; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.
Kotsifaki D; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.
Kanavouras K; Neurology Laboratory, Medical School, University of Crete, Heraklion, Crete, Greece.; Department of Neurology, 'G. Gennimatas' General Hospital, Athens, Greece.
Sarrou I; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.; Center for Free-Electron Laser Science/DESY, Hamburg, Germany.
Plaitakis A; Neurology Laboratory, Medical School, University of Crete, Heraklion, Crete, Greece.
Zaganas I; Neurology Laboratory, Medical School, University of Crete, Heraklion, Crete, Greece.
Kokkinidis M; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.; Department of Biology, University of Crete, Heraklion, Crete, Greece.
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Źródło :
Journal of neurochemistry [J Neurochem] 2021 May; Vol. 157 (3), pp. 802-815. Date of Electronic Publication: 2021 Jan 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*enzymology
Brain/*physiology
Glutamate Dehydrogenase/*physiology
Neoplasms/*enzymology
Neoplasms/*physiopathology
Amino Acid Substitution ; Animals ; Cell Line ; Crystallization ; Glutamate Dehydrogenase/antagonists & inhibitors ; Glutamate Dehydrogenase/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Mutation ; Protein Conformation ; Recombinant Proteins ; Spodoptera ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme.
Autorzy :
Lázaro M; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801 A, Derio, Spain.
Melero R; Centro Nacional de Biotecnología, CNB-CSIC, Darwin 3, Madrid, Spain.
Huet C; Unité de Microbiologie Structurale, Institut Pasteur, CNRS UMR 3528, Université de Paris, 25 rue du Docteur Roux, Paris, France.; CH, DBV-Technologies, 177-181 Avenue Pierre Brossolette, 92120 Montrouge, France; EMB, Unité de Microbiologie Structurale, Institut Pasteur, CNRS UMR 3528, Université de Paris, 25 rue du Docteur Roux, Paris, France.
López-Alonso JP; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801 A, Derio, Spain.
Delgado S; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801 A, Derio, Spain.
Dodu A; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801 A, Derio, Spain.
Bruch EM; Integrated Structural Biology Department, IGBMC, 1 Rue Laurent Fries, Illkirch, France.; CH, DBV-Technologies, 177-181 Avenue Pierre Brossolette, 92120 Montrouge, France; EMB, Unité de Microbiologie Structurale, Institut Pasteur, CNRS UMR 3528, Université de Paris, 25 rue du Docteur Roux, Paris, France.
Abriata LA; Laboratory for Biomolecular Modeling, School of Life Sciences, École Polytechnique Fédérale de Lausanne and Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Protein Production and Structure Core Facility, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Alzari PM; Unité de Microbiologie Structurale, Institut Pasteur, CNRS UMR 3528, Université de Paris, 25 rue du Docteur Roux, Paris, France.
Valle M; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801 A, Derio, Spain. .
Lisa MN; Unité de Microbiologie Structurale, Institut Pasteur, CNRS UMR 3528, Université de Paris, 25 rue du Docteur Roux, Paris, France. .; Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Ocampo y Esmeralda, Rosario, Argentina. .; Plataforma de Biología Estructural y Metabolómica (PLABEM), Ocampo y Esmeralda, Rosario, Argentina. .
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Źródło :
Communications biology [Commun Biol] 2021 Jun 03; Vol. 4 (1), pp. 684. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*chemistry
Glutamate Dehydrogenase/*chemistry
Mycobacterium smegmatis/*enzymology
Recombinant Proteins/*chemistry
Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Catalytic Domain ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Glutamate Dehydrogenase/metabolism ; Glutamate Dehydrogenase/ultrastructure ; Kinetics ; Models, Molecular ; Mycobacterium smegmatis/genetics ; Protein Binding ; Protein Domains ; Protein Multimerization ; Recombinant Proteins/metabolism ; Recombinant Proteins/ultrastructure
Czasopismo naukowe
Tytuł :
A Legionella effector ADP-ribosyltransferase inactivates glutamate dehydrogenase.
Autorzy :
Black MH; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Osinski A; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Park GJ; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Gradowski M; Institute of Biology, Warsaw University of Life Sciences, Warsaw, Poland.
Servage KA; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Molecular Biology, University of Texas Southwestern Medical Center, Howard Hughes Medical Institute, Dallas, Texas, USA.
Pawłowski K; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Institute of Biology, Warsaw University of Life Sciences, Warsaw, Poland.
Tagliabracci VS; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100301. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
ADP Ribose Transferases/*chemistry
Bacterial Proteins/*chemistry
Glutamate Dehydrogenase/*chemistry
Legionella pneumophila/*genetics
ADP Ribose Transferases/genetics ; ADP Ribose Transferases/metabolism ; ADP-Ribosylation ; Amino Acid Sequence ; Amoeba/microbiology ; Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Binding Sites ; Cloning, Molecular ; Deamination ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fungi ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Glutamate Dehydrogenase/genetics ; Glutamate Dehydrogenase/metabolism ; Host-Pathogen Interactions ; Kinetics ; Legionella pneumophila/enzymology ; Legionella pneumophila/pathogenicity ; Models, Molecular ; Oxidation-Reduction ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Regulation of the activity of maize glutamate dehydrogenase by ammonium and potassium.
Autorzy :
Zhao Y; College of Plant Science, Jilin University, Changchun, China.
Gao J; College of Plant Science, Jilin University, Changchun, China.
Su S; College of Plant Science, Jilin University, Changchun, China.
Shan X; College of Plant Science, Jilin University, Changchun, China.
Li S; College of Plant Science, Jilin University, Changchun, China.
Liu H; College of Plant Science, Jilin University, Changchun, China.
Yuan Y; College of Plant Science, Jilin University, Changchun, China.
Li H; College of Plant Science, Jilin University, Changchun, China.
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Źródło :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2021 Feb 18; Vol. 85 (2), pp. 262-271.
Typ publikacji :
Journal Article
MeSH Terms :
Ammonium Compounds/*pharmacology
Glutamate Dehydrogenase/*metabolism
Potassium/*pharmacology
Zea mays/*enzymology
Amino Acid Sequence ; Dose-Response Relationship, Drug ; Glutamate Dehydrogenase/chemistry ; Kinetics ; Models, Molecular ; Protein Conformation
Czasopismo naukowe
Tytuł :
NADP-dependent glutamate dehydrogenases in a dimorphic zygomycete Benjaminiella poitrasii: Purification, characterization and their evaluation as an antifungal drug target.
Autorzy :
Pathan EK; Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune 411008, India. Electronic address: .
Kulkarni AM; Division of organic chemistry, CSIR-National Chemical Laboratory, Pune 411008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Prasanna NVL; Division of organic chemistry, CSIR-National Chemical Laboratory, Pune 411008, India.
Ramana CV; Division of organic chemistry, CSIR-National Chemical Laboratory, Pune 411008, India.
Deshpande MV; Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune 411008, India. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2020 Nov; Vol. 1864 (11), pp. 129696. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antifungal Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Glutamate Dehydrogenase (NADP+)/*antagonists & inhibitors
Glutamate Dehydrogenase (NADP+)/*metabolism
Mucorales/*enzymology
Animals ; Antifungal Agents/chemistry ; Drug Design ; Enzyme Inhibitors/chemistry ; Fungal Proteins/antagonists & inhibitors ; Fungal Proteins/chemistry ; Fungal Proteins/metabolism ; Glutamate Dehydrogenase (NADP+)/isolation & purification ; Humans ; Mucorales/chemistry ; Mucorales/drug effects ; Mucorales/metabolism ; Mucormycosis/drug therapy ; Mucormycosis/microbiology ; Phosphorylation/drug effects ; Sheep
SCR Organism :
Benjaminiella poitrasii
Czasopismo naukowe
Tytuł :
Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology.
Autorzy :
Lemoine D; Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France.
Mondoloni S; Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France.
Tange J; Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France.
Lambolez B; Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France.
Faure P; Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France.
Taly A; CNRS, Université de Paris, UPR 9080, Laboratoire de Biochimie Théorique, Paris, France.; Institut de Biologie Physico-Chimique-Fondation Edmond de Rothschild, PSL Research University, Paris, France.
Tricoire L; Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France.
Mourot A; Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France.
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Źródło :
ELife [Elife] 2020 Oct 28; Vol. 9. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glutamate Dehydrogenase/*genetics
Glutamate Dehydrogenase/*metabolism
Binding Sites ; Genetic Engineering ; Glutamate Dehydrogenase/chemistry ; Glutamates/chemistry ; Glutamates/metabolism ; HEK293 Cells ; Humans ; Light ; Mutation
Czasopismo naukowe
Tytuł :
Valine acts as a nutritional signal in brain to activate TORC1 and attenuate postprandial ammonia-N excretion in Chinese perch (Siniperca chuatsi).
Autorzy :
Wang J; College of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan, 430070, Hubei Province, China.; Innovation Base for Chinese Perch Breeding, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan, 430070, China.
Liang XF; College of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan, 430070, Hubei Province, China. .; Innovation Base for Chinese Perch Breeding, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan, 430070, China. .
He S; College of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan, 430070, Hubei Province, China.; Innovation Base for Chinese Perch Breeding, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan, 430070, China.
Zhang YP; College of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan, 430070, Hubei Province, China.; Innovation Base for Chinese Perch Breeding, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan, 430070, China.
Li J; College of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan, 430070, Hubei Province, China.; Innovation Base for Chinese Perch Breeding, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan, 430070, China.
Huang K; College of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan, 430070, Hubei Province, China.; Innovation Base for Chinese Perch Breeding, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan, 430070, China.
Shi LJ; College of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan, 430070, Hubei Province, China.; Innovation Base for Chinese Perch Breeding, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan, 430070, China.
Ren P; College of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan, 430070, Hubei Province, China.; Innovation Base for Chinese Perch Breeding, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan, 430070, China.
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Źródło :
Fish physiology and biochemistry [Fish Physiol Biochem] 2020 Dec; Vol. 46 (6), pp. 2015-2025. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Randomized Controlled Trial, Veterinary
MeSH Terms :
AMP Deaminase/*metabolism
Ammonia/*metabolism
Brain/*drug effects
Fish Proteins/*metabolism
Glutamate Dehydrogenase/*metabolism
Mechanistic Target of Rapamycin Complex 1/*metabolism
Perches/*metabolism
Valine/*pharmacology
AMP Deaminase/genetics ; Animals ; Brain/metabolism ; Fish Proteins/genetics ; Glutamate Dehydrogenase/genetics ; Injections, Intraventricular ; Liver/drug effects ; Liver/metabolism ; Muscles/drug effects ; Muscles/metabolism ; Perches/genetics ; Postprandial Period ; Ribosomal Protein S6/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease.
Autorzy :
Zhang W; Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, 510120, Guangzhou, China.; Key Laboratory of Neurological Function and Health, School of Basic Medical Sciences, Guangzhou Medical University, 511436, Guangzhou, China.
Gong J; Key Laboratory of Neurological Function and Health, School of Basic Medical Sciences, Guangzhou Medical University, 511436, Guangzhou, China.
Ding L; Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, 510120, Guangzhou, China.
Zhang Z; Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, 510120, Guangzhou, China.
Pan X; Key Laboratory of Neurological Function and Health, School of Basic Medical Sciences, Guangzhou Medical University, 511436, Guangzhou, China.
Chen X; Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, 510120, Guangzhou, China.
Guo W; Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, 510120, Guangzhou, China.
Zhang X; The First Affiliated Hospital of Gannan Medical University, 341000, Ganzhou, China.
Yang X; Department of Neurology, The Second Affiliated Hospital of Xinjiang Medical University, 830011, Urumqi, China.
Peng G; Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, 510120, Guangzhou, China.
Lin Y; Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, 510120, Guangzhou, China.
Gao F; Key Laboratory of Neurological Function and Health, School of Basic Medical Sciences, Guangzhou Medical University, 511436, Guangzhou, China.
Li Y; Key Laboratory of Neurological Function and Health, School of Basic Medical Sciences, Guangzhou Medical University, 511436, Guangzhou, China.
Zhu X; Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University, 511436, Guangzhou, China.
Xuan A; Key Laboratory of Neurological Function and Health, School of Basic Medical Sciences, Guangzhou Medical University, 511436, Guangzhou, China.
Wang S; Key Laboratory of Neurological Function and Health, School of Basic Medical Sciences, Guangzhou Medical University, 511436, Guangzhou, China.
Sun X; Key Laboratory of Neurological Function and Health, School of Basic Medical Sciences, Guangzhou Medical University, 511436, Guangzhou, China.
Zhang Y; Key Laboratory of Neurological Function and Health, School of Basic Medical Sciences, Guangzhou Medical University, 511436, Guangzhou, China. .
Xu P; Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, 510120, Guangzhou, China. .
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Źródło :
Cell death & disease [Cell Death Dis] 2020 Oct 22; Vol. 11 (10), pp. 897. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glutamate Dehydrogenase/*genetics
Parkinson Disease/*genetics
Succinate Dehydrogenase/*metabolism
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology ; Amino Acid Transport System X-AG/metabolism ; Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Cell Death/drug effects ; Cell Line, Tumor ; Citric Acid Cycle/drug effects ; Disease Models, Animal ; Dopaminergic Neurons/metabolism ; Genetic Predisposition to Disease ; Glutamate Dehydrogenase/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Electron, Transmission ; Mitochondria/drug effects ; Mitochondria/enzymology ; Mitochondria/ultrastructure ; Mutation ; NF-E2-Related Factor 2/metabolism ; Parkinson Disease/enzymology ; Risk Factors ; Substantia Nigra/drug effects ; Substantia Nigra/metabolism
Czasopismo naukowe
Tytuł :
Assessment of Force Field Accuracy Using Cryogenic Electron Microscopy Data of Hyper-thermostable Glutamate Dehydrogenase.
Autorzy :
Oroguchi T; Department of Physics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoko-ku, Yokohama, Kanagawa 223-8522, Japan.; RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan.
Oide M; Department of Physics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoko-ku, Yokohama, Kanagawa 223-8522, Japan.; RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan.
Wakabayashi T; Department of Physics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoko-ku, Yokohama, Kanagawa 223-8522, Japan.; RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan.
Nakasako M; Department of Physics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoko-ku, Yokohama, Kanagawa 223-8522, Japan.; RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan.
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Źródło :
The journal of physical chemistry. B [J Phys Chem B] 2020 Oct 01; Vol. 124 (39), pp. 8479-8494. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glutamate Dehydrogenase*
Molecular Dynamics Simulation*
Cryoelectron Microscopy ; Proteins ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Energy landscape of domain motion in glutamate dehydrogenase deduced from cryo-electron microscopy.
Autorzy :
Oide M; Department of Physics, Faculty of Science and Technology, Keio University, Yokohama, Japan.; RIKEN SPring-8 Center, Sayo-gun, Japan.
Kato T; Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Oroguchi T; Department of Physics, Faculty of Science and Technology, Keio University, Yokohama, Japan.; RIKEN SPring-8 Center, Sayo-gun, Japan.
Nakasako M; Department of Physics, Faculty of Science and Technology, Keio University, Yokohama, Japan.; RIKEN SPring-8 Center, Sayo-gun, Japan.
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Źródło :
The FEBS journal [FEBS J] 2020 Aug; Vol. 287 (16), pp. 3472-3493. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Dynamics Simulation*
Protein Domains*
Archaeal Proteins/*chemistry
Glutamate Dehydrogenase/*chemistry
Thermococcus/*enzymology
Algorithms ; Archaeal Proteins/metabolism ; Archaeal Proteins/ultrastructure ; Cryoelectron Microscopy ; Energy Transfer ; Glutamate Dehydrogenase/metabolism ; Glutamate Dehydrogenase/ultrastructure ; Motion ; Thermodynamics
Czasopismo naukowe
Tytuł :
Correction: Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans.
Autorzy :
Silao, Fitz Gerald S. (AUTHOR)
Ryman, Kicki (AUTHOR)
Jiang, Tong (AUTHOR)
Ward, Meliza (AUTHOR)
Hansmann, Nicolas (AUTHOR)
Molenaar, Chris (AUTHOR)
Liu, Ning-Ning (AUTHOR)
Chen, Changbin (AUTHOR)
Ljungdahl, Per O. (AUTHOR)
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Źródło :
PLoS Pathogens. 8/30/2021, Vol. 17 Issue 8, p1-10. 10p.
Czasopismo naukowe
Tytuł :
Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.
Autorzy :
Lander SS; Department of Psychology, University of Haifa, Haifa, Israel.
Chornyy S; Department of Psychology, University of Haifa, Haifa, Israel.
Safory H; Department of Biochemistry, The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Gross A; Department of Psychology, University of Haifa, Haifa, Israel.
Wolosker H; Department of Biochemistry, The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Gaisler-Salomon I; Department of Psychology, University of Haifa, Haifa, Israel.
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Źródło :
Genes, brain, and behavior [Genes Brain Behav] 2020 Jul; Vol. 19 (6), pp. e12636. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Pattern Recognition, Visual*
CA1 Region, Hippocampal/*metabolism
Glutamate Dehydrogenase/*genetics
Glutamic Acid/*metabolism
Prefrontal Cortex/*metabolism
Animals ; CA1 Region, Hippocampal/physiology ; Female ; Glutamate Dehydrogenase/deficiency ; Homeostasis ; Male ; Mice ; Mice, Inbred C57BL ; Prefrontal Cortex/physiology ; Spatial Memory ; Synaptic Potentials
Czasopismo naukowe
Tytuł :
Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans.
Autorzy :
Silao FGS; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Sweden.
Ryman K; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Sweden.
Jiang T; The Center for Microbe, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, China.; University of Chinese Academy of Sciences, China.
Ward M; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Sweden.
Hansmann N; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Sweden.
Molenaar C; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Sweden.
Liu NN; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Chen C; The Center for Microbe, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, China.
Ljungdahl PO; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Sweden.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 16; Vol. 16 (9), pp. e1008328. Date of Electronic Publication: 2020 Sep 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Candida albicans/*immunology
Candidiasis/*immunology
Drosophila melanogaster/*immunology
Glutamate Dehydrogenase/*metabolism
Macrophages/*immunology
Amino Acids/genetics ; Amino Acids/metabolism ; Animals ; Candida albicans/pathogenicity ; Candidiasis/metabolism ; Candidiasis/microbiology ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/microbiology ; Female ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Glutamate Dehydrogenase/genetics ; Host-Pathogen Interactions ; Hydrogen-Ion Concentration ; Macrophages/microbiology ; Mice ; Mice, Inbred C57BL ; Nitrogen ; Phagosomes/immunology ; Phagosomes/metabolism ; Phagosomes/microbiology ; Virulence
Czasopismo naukowe
Tytuł :
Immunochromatographic test and ELISA for the detection of glutamate dehydrogenase (GDH) and A/B toxins as an alternative for the diagnosis of Clostridioides (Clostridium) difficile-associated diarrhea in foals and neonatal piglets.
Autorzy :
Ramos CP; Veterinary School, Universidade Federal de Minas Gerais, Antônio Carlos Avenue, Belo Horizonte, MG, Brazil.
Lopes EO; Veterinary School, Universidade Federal de Minas Gerais, Antônio Carlos Avenue, Belo Horizonte, MG, Brazil.
Oliveira Júnior CA; Veterinary School, Universidade Federal de Minas Gerais, Antônio Carlos Avenue, Belo Horizonte, MG, Brazil.
Diniz AN; Veterinary School, Universidade Federal de Minas Gerais, Antônio Carlos Avenue, Belo Horizonte, MG, Brazil.
Lobato FCF; Veterinary School, Universidade Federal de Minas Gerais, Antônio Carlos Avenue, Belo Horizonte, MG, Brazil.
Silva ROS; Veterinary School, Universidade Federal de Minas Gerais, Antônio Carlos Avenue, Belo Horizonte, MG, Brazil. .
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Źródło :
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2020 Sep; Vol. 51 (3), pp. 1459-1462. Date of Electronic Publication: 2020 May 03.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Bacterial Toxins/*analysis
Clostridioides difficile/*isolation & purification
Diarrhea/*veterinary
Enzyme-Linked Immunosorbent Assay/*methods
Glutamate Dehydrogenase/*analysis
Horse Diseases/*microbiology
Immunoassay/*methods
Swine Diseases/*microbiology
Animals ; Animals, Newborn/microbiology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bacterial Toxins/metabolism ; Brazil ; Clostridioides difficile/enzymology ; Clostridioides difficile/metabolism ; Clostridium Infections/diagnosis ; Clostridium Infections/microbiology ; Clostridium Infections/veterinary ; Diarrhea/diagnosis ; Diarrhea/microbiology ; Feces/microbiology ; Glutamate Dehydrogenase/metabolism ; Horse Diseases/diagnosis ; Horses ; Immunoassay/veterinary ; Swine ; Swine Diseases/diagnosis
Czasopismo naukowe
Tytuł :
Evaluation of glutamate dehydrogenase (GDH) and toxin A/B rapid tests for Clostridioides (prev. Clostridium) difficile diagnosis in a university hospital in Minas Gerais, Brazil.
Autorzy :
Ramos CP; Veterinary School, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31.270-901, Brazil.
Lopes EO; Veterinary School, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31.270-901, Brazil.
Diniz AN; Veterinary School, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31.270-901, Brazil.
Lobato FCF; Veterinary School, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31.270-901, Brazil.
Vilela EG; Faculty of Medicine, Federal University of Minas Gerais, Prof. Alfredo Balena Avenue, 190, Belo Horizonte, MG, 30.130-100, Brazil.; Alfa Institute of Gastroenterology, Clinical Hospital of Federal University of Minas Gerais, Prof. Alfredo Balena Avenue, 110, Belo Horizonte, MG, 30.130-100, Brazil.
Silva ROS; Veterinary School, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31.270-901, Brazil. .
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Źródło :
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2020 Sep; Vol. 51 (3), pp. 1139-1143. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Bacterial Proteins/*analysis
Bacterial Toxins/*analysis
Clostridioides difficile/*enzymology
Clostridium Infections/*diagnosis
Enzyme-Linked Immunosorbent Assay/*methods
Glutamate Dehydrogenase/*analysis
Immunoassay/*methods
Bacterial Proteins/metabolism ; Bacterial Toxins/metabolism ; Brazil ; Clostridioides ; Clostridioides difficile/chemistry ; Clostridioides difficile/metabolism ; Clostridium Infections/microbiology ; Diagnostic Tests, Routine/methods ; Glutamate Dehydrogenase/metabolism ; Hospitals, University ; Humans
Czasopismo naukowe
Tytuł :
Diurnal regulation of the function of the rat brain glutamate dehydrogenase by acetylation and its dependence on thiamine administration.
Autorzy :
Aleshin VA; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.; A.N.Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Mkrtchyan GV; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
Kaehne T; Institute of Experimental Internal Medicine, Otto-von-Guericke University, Magdeburg, Germany.
Graf AV; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.; Faculty of Nano-, Bio-, Informational, Cognitive and Socio-humanistic Sciences and Technologies at Moscow Institute of Physics and Technology, Moscow, Russia.
Maslova MV; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
Bunik VI; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.; A.N.Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 Apr; Vol. 153 (1), pp. 80-102. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*enzymology
Circadian Rhythm/*physiology
Glutamate Dehydrogenase/*physiology
Thiamine/*pharmacology
Acetyl Coenzyme A/pharmacology ; Acetylation ; Allosteric Regulation/drug effects ; Animals ; Cerebral Cortex/enzymology ; Glutamate Dehydrogenase/antagonists & inhibitors ; Glutamate Dehydrogenase/chemistry ; Male ; Mitochondria/enzymology ; NAD/pharmacology ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Glutamate dehydrogenase: a novel candidate to diagnose Plasmodium falciparum through rapid diagnostic test in blood specimen from fever patients.
Autorzy :
Kori LD; ICMR-National Institute of Malaria Research, Dwarka-8, New Delhi, 110077, India.
Valecha N; Former Director, ICMR-National Institute of Malaria Research, Dwarka-8, New Delhi, 110077, India.
Anvikar AR; ICMR-National Institute of Malaria Research, Dwarka-8, New Delhi, 110077, India. .
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Źródło :
Scientific reports [Sci Rep] 2020 Apr 14; Vol. 10 (1), pp. 6307. Date of Electronic Publication: 2020 Apr 14.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Protozoan/*blood
Glutamate Dehydrogenase/*blood
Malaria, Falciparum/*diagnosis
Plasmodium falciparum/*immunology
Protozoan Proteins/*blood
Antibodies, Protozoan/immunology ; Antigens, Protozoan/immunology ; Antigens, Protozoan/isolation & purification ; Biomarkers/blood ; Chromatography, Affinity/methods ; Enzyme-Linked Immunosorbent Assay ; Glutamate Dehydrogenase/immunology ; Glutamate Dehydrogenase/isolation & purification ; Humans ; India ; Malaria, Falciparum/blood ; Malaria, Falciparum/parasitology ; Plasmodium falciparum/genetics ; Plasmodium falciparum/isolation & purification ; Protozoan Proteins/immunology ; Protozoan Proteins/isolation & purification ; Recombinant Proteins/immunology ; Recombinant Proteins/isolation & purification
Czasopismo naukowe
Tytuł :
Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase.
Autorzy :
Luczkowska K; Department of Cell Physiology and Metabolism, University of Geneva Medical Center, 1206, Geneva, Switzerland.; Faculty Diabetes Center, University of Geneva Medical Center, 1206, Geneva, Switzerland.
Stekelenburg C; Faculty Diabetes Center, University of Geneva Medical Center, 1206, Geneva, Switzerland.; Pediatric Endocrine and Diabetes Unit, Department of Pediatrics Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.
Sloan-Béna F; Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, 1211, Geneva, Switzerland.; Department of Genetic Medicine and Laboratory, University Hospitals of Geneva, 1211, Geneva, Switzerland.
Ranza E; Department of Genetic Medicine and Laboratory, University Hospitals of Geneva, 1211, Geneva, Switzerland.
Gastaldi G; Faculty Diabetes Center, University of Geneva Medical Center, 1206, Geneva, Switzerland.; Division of Endocrinology, Diabetology, Hypertension and Nutrition, Geneva University Hospitals, 1211, Geneva, Switzerland.
Schwitzgebel V; Faculty Diabetes Center, University of Geneva Medical Center, 1206, Geneva, Switzerland.; Pediatric Endocrine and Diabetes Unit, Department of Pediatrics Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.
Maechler P; Department of Cell Physiology and Metabolism, University of Geneva Medical Center, 1206, Geneva, Switzerland. .; Faculty Diabetes Center, University of Geneva Medical Center, 1206, Geneva, Switzerland. .
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Źródło :
Human genomics [Hum Genomics] 2020 Mar 06; Vol. 14 (1), pp. 9. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Glutamate Dehydrogenase/*genetics
Glutamate Dehydrogenase/*metabolism
Guanosine Triphosphate/*metabolism
Hyperinsulinism/*pathology
Lymphocytes/*pathology
Adult ; Allosteric Regulation ; Case-Control Studies ; Female ; Glutamate Dehydrogenase/chemistry ; Humans ; Hyperinsulinism/genetics ; Infant, Newborn ; Lymphocytes/metabolism ; Male ; Middle Aged ; Protein Conformation
Czasopismo naukowe
Tytuł :
Mapping the Intramolecular Communications among Different Glutamate Dehydrogenase States Using Molecular Dynamics.
Autorzy :
Basith S; Department of Physiology, School of Medicine, Ajou University, Suwon 16499, Korea.
Manavalan B; Department of Physiology, School of Medicine, Ajou University, Suwon 16499, Korea.
Shin TH; Department of Physiology, School of Medicine, Ajou University, Suwon 16499, Korea.
Lee G; Department of Physiology, School of Medicine, Ajou University, Suwon 16499, Korea.; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.
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Źródło :
Biomolecules [Biomolecules] 2021 May 27; Vol. 11 (6). Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Dynamics Simulation*
Glutamate Dehydrogenase/*chemistry
Humans ; Structure-Activity Relationship
Czasopismo naukowe

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