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Tytuł :
Efficacy of oral administration of cystine and theanine in colorectal cancer patients undergoing capecitabine-based adjuvant chemotherapy after surgery: a multi-institutional, randomized, double-blinded, placebo-controlled, phase II trial (JORTC-CAM03).
Autorzy :
Hamaguchi R; Department of Palliative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. .; Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. .
Tsuchiya T; Department of Gastroenterological Surgery, Sendai City Medical Center, Sendai Open Hospital, Sendai, Miyagi, Japan.
Miyata G; Department of Gastroenterological Surgery, Iwate Prefectural Central Hospital, Morioka, Iwate, Japan.
Sato T; Department of Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Takahashi K; Department of Colorectal Surgery, Tohoku Rosai Hospital, Sendai, Miyagi, Japan.
Miura K; Department of Surgery, Miyagi Cancer Center, Sendai, Miyagi, Japan.
Oshio H; Department of Surgery, Sendai Medical Center, Sendai, Miyagi, Japan.
Ohori H; Department of Clinical Oncology, Ishinomaki Red Cross Hospital, Ishinomaki, Miyagi, Japan.
Ariyoshi K; JORTC Data Center, Tokyo, Japan.
Oyamada S; JORTC Data Center, Tokyo, Japan.
Iwase S; Department of Palliative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Emergency & Palliative Medicine, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
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Źródło :
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2020 Aug; Vol. 28 (8), pp. 3649-3657. Date of Electronic Publication: 2019 Dec 06.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*adverse effects
Colorectal Neoplasms/*drug therapy
Cystine/*therapeutic use
Glutamates/*therapeutic use
Administration, Oral ; Adult ; Aged ; Aged, 80 and over ; Anorexia/chemically induced ; Anorexia/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Capecitabine/administration & dosage ; Capecitabine/adverse effects ; Chemotherapy, Adjuvant ; Colorectal Neoplasms/surgery ; Cystine/adverse effects ; Diarrhea/chemically induced ; Diarrhea/drug therapy ; Double-Blind Method ; Drug-Related Side Effects and Adverse Reactions/drug therapy ; Female ; Glutamates/adverse effects ; Hand-Foot Syndrome/drug therapy ; Hand-Foot Syndrome/etiology ; Humans ; Male ; Middle Aged ; Stomatitis/chemically induced ; Stomatitis/drug therapy
Czasopismo naukowe
Tytuł :
Ultrasound enhanced biosynthesis of L-theanine from L-glutamine and ethylamine by recombinant γ-glutamyltranspeptidase.
Autorzy :
Xu L; Department of Life and Food Science, Suzhou University, Suzhou 234000, China. Electronic address: .
Han F; Department of Life and Food Science, Suzhou University, Suzhou 234000, China.
Zhang X; Department of Life and Food Science, Suzhou University, Suzhou 234000, China.
Yu Q; Department of Life and Food Science, Suzhou University, Suzhou 234000, China.
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Źródło :
Bioresource technology [Bioresour Technol] 2020 Jul; Vol. 307, pp. 123251. Date of Electronic Publication: 2020 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Glutamates*
Glutamine*
Ethylamines ; gamma-Glutamyltransferase
Czasopismo naukowe
Tytuł :
l-theanine alleviates liver and kidney dysfunction in septic rats induced by cecal ligation and puncture.
Autorzy :
Malkoç M; Vocational School of Health Sciences, Karadeniz Technical University, 61080 Trabzon, Turkey. Electronic address: .
Patan H; Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
Yaman SÖ; Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
Türedi S; Karadeniz Technical University, Faculty of Medicine, Department of Emergency Medicine, 61080 Trabzon, Turkey.
Kerimoğlu G; Karadeniz Technical University, Faculty of Medicine, Department of Histology, 61080 Trabzon, Turkey.
Kural BV; Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
Örem A; Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
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Źródło :
Life sciences [Life Sci] 2020 May 15; Vol. 249, pp. 117502. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Cecum/*pathology
Glutamates/*pharmacology
Kidney/*drug effects
Liver/*drug effects
Sepsis/*physiopathology
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Dose-Response Relationship, Drug ; Glutamates/administration & dosage ; Kidney/physiopathology ; Ligation ; Liver/physiopathology ; Male ; Oxidative Stress/drug effects ; Punctures ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Effects of dietary crude protein level and N-carbamylglutamate supplementation on nutrient digestibility and digestive enzyme activity of jejunum in growing pigs.
Autorzy :
Wang Y; Beijing Advanced Innovation Health Center for Food Nutrition and Human Health, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Han S; Beijing Advanced Innovation Health Center for Food Nutrition and Human Health, College of Animal Science and Technology, China Agricultural University, Beijing, China.; College of Animal Science and Technology, Hebei Agricultural University, Baoding, China.
Zhou J; Beijing Advanced Innovation Health Center for Food Nutrition and Human Health, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Li P; Beijing Advanced Innovation Health Center for Food Nutrition and Human Health, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Wang G; Beijing Advanced Innovation Health Center for Food Nutrition and Human Health, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Yu H; Beijing Advanced Innovation Health Center for Food Nutrition and Human Health, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Cai S; Beijing Advanced Innovation Health Center for Food Nutrition and Human Health, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Zeng X; Beijing Advanced Innovation Health Center for Food Nutrition and Human Health, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Johnston LJ; West Central Research and Outreach Center, University of Minnesota, Morris, MN.
Levesque CL; Department of Animal Sciences, South Dakota State University, Brookings, SD.
Qiao S; Beijing Advanced Innovation Health Center for Food Nutrition and Human Health, College of Animal Science and Technology, China Agricultural University, Beijing, China.
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Źródło :
Journal of animal science [J Anim Sci] 2020 Apr 01; Vol. 98 (4).
Typ publikacji :
Journal Article; Randomized Controlled Trial, Veterinary
MeSH Terms :
Animal Feed/*analysis
Diet/*veterinary
Dietary Proteins/*administration & dosage
Glutamates/*administration & dosage
Swine/*physiology
Amino Acids/metabolism ; Animal Nutritional Physiological Phenomena ; Animals ; Dietary Proteins/pharmacology ; Dietary Supplements ; Digestion/drug effects ; Energy Metabolism/drug effects ; Gastrointestinal Tract/metabolism ; Glutamates/pharmacology ; Ileum/metabolism ; Jejunum/metabolism ; Male
Czasopismo naukowe
Tytuł :
The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
Autorzy :
Williams JL; Faculty of Health, University of Canberra, Canberra, ACT, 2601, Australia.; Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, University of Canberra, Bruce, ACT, 2601, Australia.
Everett JM; Faculty of Health, University of Canberra, Canberra, ACT, 2601, Australia.
D'Cunha NM; Faculty of Health, University of Canberra, Canberra, ACT, 2601, Australia.; Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, University of Canberra, Bruce, ACT, 2601, Australia.
Sergi D; Nutrition & Health Substantiation Group, Nutrition and Health Program, Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Adelaide, SA, 5000, Australia.
Georgousopoulou EN; Australian National University Medical School, Australian National University, Canberra, ACT, 2605, Australia.; School of Medicine, University of Notre Dame Australia, Sydney, NSW, 2000, Australia.
Keegan RJ; Faculty of Health, University of Canberra, Canberra, ACT, 2601, Australia.; Research Institute for Sports and Exercise, University of Canberra, Canberra, ACT, 2601, Australia.
McKune AJ; Faculty of Health, University of Canberra, Canberra, ACT, 2601, Australia.; Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, University of Canberra, Bruce, ACT, 2601, Australia.; Research Institute for Sports and Exercise, University of Canberra, Canberra, ACT, 2601, Australia.; Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, KwaZulu-Natal, 4000, South Africa.
Mellor DD; Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, University of Canberra, Bruce, ACT, 2601, Australia.; Aston Medical School, Aston University, Birmingham, B4 7ET, UK.
Anstice N; Faculty of Health, University of Canberra, Canberra, ACT, 2601, Australia.; Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, University of Canberra, Bruce, ACT, 2601, Australia.
Naumovski N; Faculty of Health, University of Canberra, Canberra, ACT, 2601, Australia. .; Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, University of Canberra, Bruce, ACT, 2601, Australia. .
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Źródło :
Plant foods for human nutrition (Dordrecht, Netherlands) [Plant Foods Hum Nutr] 2020 Mar; Vol. 75 (1), pp. 12-23.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Anxiety*
Glutamates*
Tea*
Amino Acids ; Humans ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses.
Autorzy :
Unno K; Tea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Sumiyoshi A; Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.; National Institutes for Quantum and Radiological Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555, Japan.
Konishi T; Faculty of Bioresource Sciences, Akita Prefectural University, Shimoshinjo Nakano, Akita 010-0195, Japan.
Hayashi M; Tea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Taguchi K; Tea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Muguruma Y; College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.
Inoue K; College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.
Iguchi K; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Nonaka H; Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Kawashima R; Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Hasegawa-Ishii S; Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka, Tokyo 181-8612, Japan.
Shimada A; Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka, Tokyo 181-8612, Japan.
Nakamura Y; Tea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
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Źródło :
Nutrients [Nutrients] 2020 Jan 08; Vol. 12 (1). Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Stress, Psychological*
Brain Diseases/*prevention & control
Glutamates/*pharmacology
Tea/*chemistry
Animals ; Atrophy/prevention & control ; Glutamates/chemistry ; Hippocampus/drug effects ; Housing, Animal ; Male ; Mice
Czasopismo naukowe
Tytuł :
Neuroprotective and Antiamnestic Effects of a New Drug Emopag in Rats.
Autorzy :
Yasnetsov VV; State Research Center Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia. .
Voronina TA; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Skachilova SY; All-Russian Research Center for Safety of Bioactive Substances, Staraya Kupavna, Russia.
Yasnetsov VV; State Research Center Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
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Źródło :
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Dec; Vol. 168 (2), pp. 247-249. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Ischemia/*drug therapy
Glutamates/*pharmacology
Memory/*drug effects
Neuroprotective Agents/*pharmacology
Pyridines/*pharmacology
Amnesia/prevention & control ; Animals ; Brain Ischemia/mortality ; Brain Ischemia/prevention & control ; Disease Models, Animal ; Glutamates/therapeutic use ; Male ; Picolines/pharmacology ; Pyridines/therapeutic use ; Rats ; Thiadiazoles/pharmacology
Czasopismo naukowe
Tytuł :
The role of glutamine in neurogenesis promoted by the green tea amino acid theanine in neural progenitor cells for brain health.
Autorzy :
Yoneda Y; Department of Pharmacology, Osaka University Graduate School of Dentistry, Suita, 565-0871, Japan; The Institute of Prophylactic Pharmacology, Kita-Shinagawa, Shinagawa, 140-0001, Tokyo, Japan. Electronic address: .
Kuramoto N; The Institute of Prophylactic Pharmacology, Kita-Shinagawa, Shinagawa, 140-0001, Tokyo, Japan; Laboratory of Molecular Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, Hirakata, 573-0101, Japan.
Kawada K; The Institute of Prophylactic Pharmacology, Kita-Shinagawa, Shinagawa, 140-0001, Tokyo, Japan; Department of Pharmacology, Chiba Institute of Science Faculty of Pharmaceutical Sciences, Chiba, 288-0025, Japan.
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Źródło :
Neurochemistry international [Neurochem Int] 2019 Oct; Vol. 129, pp. 104505. Date of Electronic Publication: 2019 Jul 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain/*drug effects
Glutamates/*pharmacology
Glutamine/*physiology
Neural Stem Cells/*drug effects
Neurogenesis/*drug effects
Neuroprotective Agents/*pharmacology
Amino Acid Transport System A/physiology ; Animals ; Cognition Disorders/drug therapy ; Cognition Disorders/prevention & control ; Double-Blind Method ; Forecasting ; Glutamates/chemistry ; Glutamates/therapeutic use ; Glutamine/chemistry ; Hippocampus/drug effects ; Humans ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice ; Mice, Transgenic ; Mood Disorders/drug therapy ; Neural Stem Cells/physiology ; Neurogenesis/physiology ; Phosphorylation/drug effects ; Phytotherapy ; Protein Processing, Post-Translational/drug effects ; Randomized Controlled Trials as Topic ; Rats ; Sleep Wake Disorders/drug therapy ; TOR Serine-Threonine Kinases/metabolism ; Tea/chemistry
Czasopismo naukowe
Tytuł :
Binding interaction of allethrin with esterase: Bioremediation potential and mechanism.
Autorzy :
Bhatt P; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Rene ER; Department of Environmental Engineering and Water Technology, IHE Delft Institute for Water Education, Westvest 7, 2601DA Delft, the Netherlands.
Kumar AJ; School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Zhang W; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Chen S; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China. Electronic address: .
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Źródło :
Bioresource technology [Bioresour Technol] 2020 Nov; Vol. 315, pp. 123845. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Allethrins*
Histidine*
Alanine ; Arginine ; Biodegradation, Environmental ; Esterases ; Glutamates ; Leucine ; Lysine ; Methionine ; Pseudomonas ; Serine ; Tyrosine
SCR Organism :
Pseudomonas nitroreducens
Czasopismo naukowe
Tytuł :
Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia.
Autorzy :
Jiang L; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Park JS; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Yin L; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Laureano R; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Jacquinet E; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Yang J; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Liang S; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Frassetto A; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Zhuo J; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Yan X; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Zhu X; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Fortucci S; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Hoar K; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Mihai C; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Tunkey C; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Presnyak V; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Benenato KE; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Lukacs CM; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA.
Martini PGV; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA. .
Guey LT; Moderna Inc., 200 Technology Square, Cambridge, MA, 02139, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 21; Vol. 11 (1), pp. 5339. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Replacement Therapy/*methods
Propionic Acidemia/*therapy
RNA, Messenger/*therapeutic use
Animals ; Disease Models, Animal ; Glutamates/therapeutic use ; Humans ; Kinetics ; Lipids/chemistry ; Liver/enzymology ; Methylmalonyl-CoA Decarboxylase/chemistry ; Methylmalonyl-CoA Decarboxylase/genetics ; Methylmalonyl-CoA Decarboxylase/metabolism ; Mice ; Mice, Knockout ; Mice, Transgenic ; Mitochondria/enzymology ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Propionic Acidemia/genetics ; Propionic Acidemia/metabolism ; Protein Subunits/chemistry ; Protein Subunits/genetics ; RNA, Messenger/administration & dosage ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
Reinventing the nutraceutical value of gluten: The case of l-theanine-gluten as a potential alternative to the gluten exclusion diet in celiac disease.
Autorzy :
Ribeiro M; CQ-VR, Chemistry Research Centre, Chemistry Department, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal. Electronic address: .
Lopes S; CQ-VR, Chemistry Research Centre, Chemistry Department, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
Picascia S; Institute of Biochemistry and Cell Biology-CNR, Via Pietro Castellino, 111, 80131 Naples, Italy.
Gianfrani C; Institute of Biochemistry and Cell Biology-CNR, Via Pietro Castellino, 111, 80131 Naples, Italy.
Nunes FM; CQ-VR, Chemistry Research Centre, Chemistry Department, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2020 Sep 15; Vol. 324, pp. 126840. Date of Electronic Publication: 2020 Apr 18.
Typ publikacji :
Journal Article
MeSH Terms :
Flour*
Celiac Disease/*immunology
Glutamates/*chemistry
Glutens/*chemistry
T-Lymphocytes/*immunology
Celiac Disease/diet therapy ; Diet, Gluten-Free ; Dietary Supplements ; Elasticity ; Ethylamines/metabolism ; Functional Food ; Glutens/metabolism ; Humans ; Intestines/cytology ; Intestines/immunology ; Transglutaminases/metabolism ; Triticum
Czasopismo naukowe
Tytuł :
Time-series transcriptomic analysis reveals novel gene modules that control theanine biosynthesis in tea plant (Camellia sinensis).
Autorzy :
Cao H; State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
He X; School of Sciences, Anhui Agricultural University, Hefei, China.
Du J; State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
Zhang R; College of Information and Computer Science, Anhui Agricultural University, Hefei, China.
Chen Y; State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
Ma Y; College of Information and Computer Science, Anhui Agricultural University, Hefei, China.
Chen Q; State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
Fang C; State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
Ho CT; Department of Food Science, Rutgers University, New Brunswick, New Jersey, United States of America.
Zhang S; College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, China.
Wan X; State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
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Źródło :
PloS one [PLoS One] 2020 Sep 10; Vol. 15 (9), pp. e0238175. Date of Electronic Publication: 2020 Sep 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Profiling*
Camellia sinensis/*genetics
Camellia sinensis/*metabolism
Genes, Plant/*genetics
Glutamates/*biosynthesis
Gene Ontology ; Gene Regulatory Networks ; Time Factors
Czasopismo naukowe
Tytuł :
Quantifying Spontaneous Ca2+ Fluxes and their Downstream Effects in Primary Mouse Midbrain Neurons.
Autorzy :
Bancroft EA; Department of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, College of Medicine.
Srinivasan R; Department of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, College of Medicine; Texas A&M Institute for Neuroscience; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2020 Sep 09 (163). Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Calcium Signaling*
Calcium/*metabolism
Dopaminergic Neurons/*cytology
Mesencephalon/*cytology
Animals ; Caspase 3/metabolism ; Cells, Cultured ; Dependovirus/genetics ; Dopaminergic Neurons/drug effects ; Embryo, Mammalian/cytology ; Genetic Vectors/metabolism ; Glutamates/pharmacology ; Image Processing, Computer-Assisted ; Mice ; Quinoxalines/pharmacology ; Receptors, AMPA/metabolism ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
Expanding the membrane-protein NMR toolkit.
Autorzy :
Cheng RC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Maduke M; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2020 Sep; Vol. 16 (9), pp. 937-938.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Amino Acid Transport System X-AG*
Membrane Proteins*
Glutamates ; Magnetic Resonance Spectroscopy ; Movement
Czasopismo naukowe
Tytuł :
Enzyme-mimetic self-catalyzed polymerization of polypeptide helices.
Autorzy :
Song Z; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Fu H; Department of Chemistry, University of Connecticut, Storrs, CT, 06269, USA.; Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT, 06269, USA.
Baumgartner R; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Zhu L; NMR laboratory, School of Chemical Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Shih KC; Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT, 06269, USA.
Xia Y; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Zheng X; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Yin L; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, Suzhou, 215123, China.
Chipot C; Theoretical and Computational Biophysics Group, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .; Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .; Laboratoire International Associé Centre National de la Recherche Scientifique et University of Illinois at Urbana-Champaign, Unité Mixte de Recherche n° 7019, Université de Lorraine, B.P. 70239, 54506, Vandœuvre-lès-Nancy, cedex, France. .
Lin Y; Department of Chemistry, University of Connecticut, Storrs, CT, 06269, USA. .; Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT, 06269, USA. .
Cheng J; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .
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Źródło :
Nature communications [Nat Commun] 2019 Nov 29; Vol. 10 (1), pp. 5470. Date of Electronic Publication: 2019 Nov 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Conformation, alpha-Helical*
Anhydrides/*metabolism
Glutamates/*metabolism
Polymers/*metabolism
Amines/chemistry ; Amines/metabolism ; Anhydrides/chemistry ; Catalysis ; Enzymes/chemistry ; Enzymes/metabolism ; Glutamates/chemistry ; Kinetics ; Magnetic Resonance Spectroscopy ; Methylene Chloride ; Models, Molecular ; Polymerization ; Polymers/chemistry
Czasopismo naukowe
Tytuł :
A Bivalent Inhibitor of Prostate Specific Membrane Antigen Radiolabeled with Copper-64 with High Tumor Uptake and Retention.
Autorzy :
Zia NA; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010, Vic., Australia.
Cullinane C; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, 3010, Vic., Australia.; Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, 3000, Australia.
Van Zuylekom JK; Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, 3000, Australia.
Waldeck K; Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, 3000, Australia.
McInnes LE; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010, Vic., Australia.
Buncic G; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010, Vic., Australia.
Haskali MB; Centre for Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, 3000, Australia.
Roselt PD; Centre for Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, 3000, Australia.
Hicks RJ; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, 3010, Vic., Australia.; Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, 3000, Australia.; Centre for Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, 3000, Australia.
Donnelly PS; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010, Vic., Australia.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Oct 14; Vol. 58 (42), pp. 14991-14994. Date of Electronic Publication: 2019 Sep 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Prostatic Neoplasms*/diagnostic imaging
Prostatic Neoplasms*/therapy
Copper Radioisotopes/*chemistry
Dipeptides/*chemistry
Glutamate Carboxypeptidase II/*antagonists & inhibitors
Glutamates/*chemistry
Radiopharmaceuticals/*chemistry
Animals ; Antigens, Surface ; Binding Sites ; Cell Line, Tumor ; Copper Radioisotopes/metabolism ; Glutamates/pharmacokinetics ; Humans ; Lysine/analogs & derivatives ; Lysine/chemistry ; Male ; Mice ; Protein Binding ; Radiopharmaceuticals/pharmacokinetics ; Theranostic Nanomedicine ; Tissue Distribution ; Urea/analogs & derivatives ; Urea/chemistry
Czasopismo naukowe
Tytuł :
L-theanine attenuates transport stress-induced impairment of meat quality of broilers through improving muscle antioxidant status.
Autorzy :
Zhang C; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Geng ZY; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Chen KK; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Zhao XH; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Wang C; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
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Źródło :
Poultry science [Poult Sci] 2019 Oct 01; Vol. 98 (10), pp. 4648-4655.
Typ publikacji :
Journal Article
MeSH Terms :
Immunity, Innate*/drug effects
Antioxidants/*metabolism
Chickens/*physiology
Glutamates/*metabolism
Meat/*analysis
Muscle, Skeletal/*physiology
Animal Feed/analysis ; Animals ; Chickens/growth & development ; Chickens/immunology ; Diet/veterinary ; Dietary Supplements/analysis ; Glutamates/administration & dosage ; Male ; Muscle, Skeletal/drug effects ; Random Allocation ; Stress, Physiological/drug effects ; Transportation
Czasopismo naukowe
Tytuł :
Comparative Transcriptomic Analysis Reveals Regulatory Mechanisms of Theanine Synthesis in Tea ( Camellia sinensis ) and Oil Tea ( Camellia oleifera ) Plants.
Autorzy :
Tai Y
Ling C
Wang H
Yang L
She G
Wang C
Yu S
Chen W
Liu C; BGI Genomics, BGI-Shenzhen , Shenzhen 518083 , China.
Wan X
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2019 Sep 11; Vol. 67 (36), pp. 10235-10244. Date of Electronic Publication: 2019 Aug 30.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Transcriptome*
Camellia/*genetics
Camellia sinensis/*genetics
Glutamates/*biosynthesis
Plant Proteins/*genetics
Camellia/chemistry ; Camellia/metabolism ; Camellia sinensis/chemistry ; Camellia sinensis/metabolism ; Glutamates/analysis ; Plant Leaves/chemistry ; Plant Leaves/genetics ; Plant Leaves/metabolism ; Plant Proteins/metabolism ; Plant Roots/chemistry ; Plant Roots/genetics ; Plant Roots/metabolism
Czasopismo naukowe
Tytuł :
Could spray-dried microbeads with chitosan glutamate be considered as promising vaginal microbicide carriers? The effect of process variables on the in vitro functional and physicochemical characteristics.
Autorzy :
Szymanska E; Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland. Electronic address: .
Czarnomysy R; Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland. Electronic address: .
Jacyna J; Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Hallera 107, 80-416 Gdansk, Poland. Electronic address: .
Basa A; Institute of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland. Electronic address: .
Wilczewska AZ; Institute of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland. Electronic address: .
Markuszewski M; Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Hallera 107, 80-416 Gdansk, Poland. Electronic address: .
Winnicka K; Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2019 Sep 10; Vol. 568, pp. 118558. Date of Electronic Publication: 2019 Jul 25.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Infective Agents/*administration & dosage
Chitosan/*administration & dosage
Drug Carriers/*administration & dosage
Glutamates/*administration & dosage
Zidovudine/*administration & dosage
Administration, Intravaginal ; Anti-Infective Agents/chemistry ; Cell Line ; Cell Survival/drug effects ; Chitosan/chemistry ; Desiccation ; Drug Carriers/chemistry ; Drug Liberation ; Female ; Glutamates/chemistry ; Humans ; Microspheres ; Vagina ; Zidovudine/chemistry
Czasopismo naukowe
Tytuł :
Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
Autorzy :
Nedelcovych MT; Johns Hopkins Drug Discovery, 855 North Wolfe Street, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kim BH; Department of Medicine, Icahn School of Medicine at Mount Sinai, Annenberg Building Floor 21, Room 42, 1468 Madison Ave, New York, NY, 10029, USA.
Zhu X; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lovell LE; Johns Hopkins Drug Discovery, 855 North Wolfe Street, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Manning AA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA.
Kelschenbach J; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, Annenberg Building Floor 21, Room 42, 1468 Madison Ave, New York, NY, 10029, USA.
Hadas E; Department of Medicine, Icahn School of Medicine at Mount Sinai, Annenberg Building Floor 21, Room 42, 1468 Madison Ave, New York, NY, 10029, USA.
Chao W; Department of Medicine, Icahn School of Medicine at Mount Sinai, Annenberg Building Floor 21, Room 42, 1468 Madison Ave, New York, NY, 10029, USA.
Prchalová E; Johns Hopkins Drug Discovery, 855 North Wolfe Street, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dash RP; Johns Hopkins Drug Discovery, 855 North Wolfe Street, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wu Y; Johns Hopkins Drug Discovery, 855 North Wolfe Street, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alt J; Johns Hopkins Drug Discovery, 855 North Wolfe Street, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Thomas AG; Johns Hopkins Drug Discovery, 855 North Wolfe Street, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rais R; Johns Hopkins Drug Discovery, 855 North Wolfe Street, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kamiya A; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Volsky DJ; Department of Medicine, Icahn School of Medicine at Mount Sinai, Annenberg Building Floor 21, Room 42, 1468 Madison Ave, New York, NY, 10029, USA. .
Slusher BS; Johns Hopkins Drug Discovery, 855 North Wolfe Street, Baltimore, MD, 21205, USA. .; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
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Źródło :
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2019 Sep; Vol. 14 (3), pp. 391-400. Date of Electronic Publication: 2019 Jun 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
AIDS Dementia Complex*
Azo Compounds/*therapeutic use
Caproates/*therapeutic use
Cognition Disorders/*drug therapy
Glutamates/*biosynthesis
Glutamine/*antagonists & inhibitors
Prodrugs/*therapeutic use
Animals ; Azo Compounds/pharmacokinetics ; CD11b Antigen/analysis ; Caproates/pharmacokinetics ; Cognition Disorders/cerebrospinal fluid ; Cognition Disorders/etiology ; Cognition Disorders/virology ; Conditioning, Classical/drug effects ; Fear ; Glutamates/cerebrospinal fluid ; HIV-1/genetics ; HIV-1/pathogenicity ; Leukemia Virus, Murine/genetics ; Leukemia Virus, Murine/pathogenicity ; Male ; Maze Learning/drug effects ; Memory, Short-Term/drug effects ; Mice ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/metabolism ; Norleucine/analogs & derivatives ; Norleucine/therapeutic use ; Prodrugs/pharmacokinetics ; Reassortant Viruses/genetics ; Reassortant Viruses/pathogenicity ; Spatial Learning/drug effects
Czasopismo naukowe

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