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Tytuł :
Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD synthetases.
Autorzy :
Chuenchor W; Departments of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
Doukov TI; Stanford Synchrotron Radiation Lightsource, Menlo Park, CA, 94025, USA.
Chang KT; Departments of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
Resto M; Departments of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
Yun CS; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Korea.
Gerratana B; Departments of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jan 07; Vol. 11 (1), pp. 16. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info :
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
MeSH Terms :
Amide Synthases/*metabolism
Ammonia/*metabolism
Bacterial Proteins/*metabolism
Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/*metabolism
Mycobacterium tuberculosis/*enzymology
Amide Synthases/chemistry ; Amide Synthases/genetics ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/chemistry ; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/genetics ; Catalytic Domain ; Glutaminase/chemistry ; Glutaminase/genetics ; Glutaminase/metabolism ; Glutamine/metabolism ; Humans ; Mycobacterium tuberculosis/chemistry ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/metabolism ; NAD/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth.
Autorzy :
Ishak Gabra MB; Department of Molecular Biology and Biochemistry; School of Biological Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Yang Y; Department of Molecular Biology and Biochemistry; School of Biological Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Li H; Center for Informatics, City of Hope National Medical Center, Duarte, CA, 91010, USA.; Department of Computational & Quantitative Medicine, Beckman Research Institute, City of Hope Medical Center, Duarte, CA, 91010, USA.
Senapati P; Department of Diabetes and Metabolic Disease, Beckman Research Institute of City of Hope Cancer Center, Duarte, CA, 91010, USA.
Hanse EA; Department of Molecular Biology and Biochemistry; School of Biological Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Lowman XH; Department of Molecular Biology and Biochemistry; School of Biological Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Tran TQ; Department of Molecular Biology and Biochemistry; School of Biological Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Zhang L; Institute for Clinical and Translational Science, University of California, Irvine, CA, 92687, USA.
Doan LT; UCI Health Dermatology Center, Irvine, CA, 92697, USA.
Xu X; Department of Pathology, University of California San Diego, La Jolla, CA, 92093, USA.
Schones DE; Department of Diabetes and Metabolic Disease, Beckman Research Institute of City of Hope Cancer Center, Duarte, CA, 91010, USA.
Fruman DA; Department of Molecular Biology and Biochemistry; School of Biological Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Kong M; Department of Molecular Biology and Biochemistry; School of Biological Sciences, University of California, Irvine, Irvine, CA, 92697, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 03; Vol. 11 (1), pp. 3326. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
MeSH Terms :
Dietary Supplements*
Cell Proliferation/*drug effects
Epigenesis, Genetic/*drug effects
Glutamine/*pharmacology
Melanoma/*prevention & control
Signal Transduction/*drug effects
Animals ; Cell Line, Tumor ; Cell Proliferation/genetics ; Epigenesis, Genetic/genetics ; Glutamine/administration & dosage ; Histones/metabolism ; Humans ; Lysine/metabolism ; Male ; Melanoma/genetics ; Melanoma/pathology ; Methylation/drug effects ; Mice, Nude ; Signal Transduction/genetics ; Transcriptome/drug effects ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Ultrasound enhanced biosynthesis of L-theanine from L-glutamine and ethylamine by recombinant γ-glutamyltranspeptidase.
Autorzy :
Xu L; Department of Life and Food Science, Suzhou University, Suzhou 234000, China. Electronic address: .
Han F; Department of Life and Food Science, Suzhou University, Suzhou 234000, China.
Zhang X; Department of Life and Food Science, Suzhou University, Suzhou 234000, China.
Yu Q; Department of Life and Food Science, Suzhou University, Suzhou 234000, China.
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Źródło :
Bioresource technology [Bioresour Technol] 2020 Jul; Vol. 307, pp. 123251. Date of Electronic Publication: 2020 Mar 26.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Applied Science Country of Publication: England NLM ID: 9889523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2976 (Electronic) Linking ISSN: 09608524 NLM ISO Abbreviation: Bioresour. Technol. Subsets: MEDLINE
MeSH Terms :
Glutamates*
Glutamine*
Ethylamines ; gamma-Glutamyltransferase
Czasopismo naukowe
Tytuł :
Short disordered protein segment regulates cross-species transmission of a yeast prion.
Autorzy :
Shida T; Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.; Laboratory for Protein Conformation Diseases, RIKEN Center for Brain Science, Wako, Japan.
Kamatari YO; Life Science Research Center, Gifu University, Gifu, Japan.; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.
Yoda T; Nagahama Institute of Bio-Science and Technology, Nagahama, Japan.; Computational Biophysics Research Team, RIKEN Research Center for Computational Science, Kobe, Japan.
Yamaguchi Y; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.; RIKEN-Max Planck Joint Research Center, Wako, Japan.
Feig M; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.; Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Ohhashi Y; Graduate School of Science, Kobe University, Kobe, Japan.; Department of Applied Chemistry, Tokyo University of Science, Shinjuku-ku, Tokyo, Japan.
Sugita Y; Computational Biophysics Research Team, RIKEN Research Center for Computational Science, Kobe, Japan.; Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.; Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, Wako, Japan.
Kuwata K; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.
Tanaka M; Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan. .; Laboratory for Protein Conformation Diseases, RIKEN Center for Brain Science, Wako, Japan. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2020 Jul; Vol. 16 (7), pp. 756-765. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
MeSH Terms :
Asparagine/*chemistry
Glutamine/*chemistry
Intrinsically Disordered Proteins/*chemistry
Peptide Termination Factors/*chemistry
Prions/*chemistry
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*chemistry
Amino Acid Sequence ; Asparagine/metabolism ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Glutamine/metabolism ; Intrinsically Disordered Proteins/genetics ; Intrinsically Disordered Proteins/metabolism ; Molecular Dynamics Simulation ; Peptide Termination Factors/genetics ; Peptide Termination Factors/metabolism ; Prions/genetics ; Prions/metabolism ; Protein Interaction Domains and Motifs ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Structure, Secondary ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Thermodynamics
Czasopismo naukowe
Tytuł :
ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.
Autorzy :
Ali ES; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Sahu U; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Villa E; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
O'Hara BP; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Gao P; Metabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Beaudet C; Cell Signaling Technology, Inc., Danvers, MA 01923, USA.
Wood AW; Cell Signaling Technology, Inc., Danvers, MA 01923, USA.
Asara JM; Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Ben-Sahra I; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jun 18; Vol. 78 (6), pp. 1178-1191.e6. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
MeSH Terms :
Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/*metabolism
Mitogen-Activated Protein Kinase 1/*metabolism
Purines/*biosynthesis
A549 Cells ; Animals ; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/genetics ; Cell Cycle/physiology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; HeLa Cells ; Humans ; MAP Kinase Signaling System/physiology ; Phosphorylation ; Purines/metabolism ; Signal Transduction/physiology ; ras Proteins/metabolism
Czasopismo naukowe
Tytuł :
Circulating Glutamine and Alzheimer's Disease: A Mendelian Randomization Study.
Autorzy :
Adams CD; Beckman Research Institute, Duarte, CA, USA.
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Źródło :
Clinical interventions in aging [Clin Interv Aging] 2020 Feb 10; Vol. 15, pp. 185-193. Date of Electronic Publication: 2020 Feb 10 (Print Publication: 2020).
Typ publikacji :
Journal Article
Journal Info :
Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101273480 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-1998 (Electronic) Linking ISSN: 11769092 NLM ISO Abbreviation: Clin Interv Aging Subsets: MEDLINE
MeSH Terms :
Alzheimer Disease*/blood
Alzheimer Disease*/metabolism
Glutamine*/blood
Glutamine*/genetics
Glutamine*/metabolism
Blood-Brain Barrier/*physiology
Brain/*metabolism
Cognitive Dysfunction/*prevention & control
Aged ; Cognition/physiology ; Female ; Genome-Wide Association Study/statistics & numerical data ; Humans ; Male ; Mendelian Randomization Analysis/methods ; Neuroprotective Agents/metabolism ; Receptors, Glutamate/metabolism
Czasopismo naukowe
Tytuł :
Glutamine and asparagine activate mTORC1 independently of Rag GTPases.
Autorzy :
Meng D; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Yang Q; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Wang H; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Melick CH; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Navlani R; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Frank AR; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Jewell JL; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 .; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Mar 06; Vol. 295 (10), pp. 2890-2899. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
MeSH Terms :
Asparagine/*metabolism
Glutamine/*metabolism
Mechanistic Target of Rapamycin Complex 1/*metabolism
Monomeric GTP-Binding Proteins/*metabolism
ADP-Ribosylation Factor 1/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Amino Acids/chemistry ; Amino Acids/pharmacology ; Animals ; Asparagine/chemistry ; Cell Cycle Proteins/metabolism ; Cell Line ; Culture Media/chemistry ; Culture Media/pharmacology ; Glutamine/chemistry ; HEK293 Cells ; Humans ; Lysosomes/metabolism ; Mechanistic Target of Rapamycin Complex 1/chemistry ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mice ; Phosphorylation ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Signal Transduction/drug effects ; Sirolimus/pharmacology
Czasopismo naukowe
Tytuł :
A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors.
Autorzy :
Nemet I; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
Saha PP; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
Gupta N; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
Zhu W; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
Romano KA; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
Skye SM; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
Cajka T; West Coast Metabolomics Center, University of California, Davis, Davis, CA 95616, USA.
Mohan ML; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Li L; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
Wu Y; Department of Mathematics, Cleveland State University, Cleveland, OH 44115, USA.
Funabashi M; Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA.
Ramer-Tait AE; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Naga Prasad SV; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Fiehn O; West Coast Metabolomics Center, University of California, Davis, Davis, CA 95616, USA.
Rey FE; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Tang WHW; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA; Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Fischbach MA; Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA.
DiDonato JA; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
Hazen SL; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA; Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44106, USA. Electronic address: .
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Źródło :
Cell [Cell] 2020 Mar 05; Vol. 180 (5), pp. 862-877.e22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Journal Info :
Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
MeSH Terms :
Cardiovascular Diseases/*blood
Gastrointestinal Microbiome/*genetics
Glutamine/*analogs & derivatives
Thrombosis/*metabolism
Animals ; Arteries/injuries ; Arteries/metabolism ; Arteries/microbiology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Blood Platelets/metabolism ; Blood Platelets/microbiology ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/microbiology ; Cardiovascular Diseases/pathology ; Death, Sudden, Cardiac/pathology ; Glutamine/blood ; Glutamine/genetics ; Humans ; Male ; Metabolome/genetics ; Metabolomics/methods ; Mice ; Myocardial Infarction/blood ; Myocardial Infarction/microbiology ; Platelet Activation/genetics ; Receptors, Adrenergic, alpha/blood ; Receptors, Adrenergic, alpha/genetics ; Receptors, Adrenergic, beta/blood ; Receptors, Adrenergic, beta/genetics ; Risk Factors ; Stroke/blood ; Stroke/microbiology ; Stroke/pathology ; Thrombosis/genetics ; Thrombosis/microbiology ; Thrombosis/pathology
Czasopismo naukowe
Tytuł :
Pharmacokinetic Assessment of F-(2 S, 4 R )-4-Fluoroglutamine in Patients with Cancer.
Autorzy :
Grkovski M; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Goel R; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Krebs S; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Staton KD; Radiochemistry and Molecular Imaging Probe Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York.
Harding JJ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; and.
Mellinghoff IK; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York.
Humm JL; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Dunphy MPS; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York .
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Źródło :
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2020 Mar; Vol. 61 (3), pp. 357-366. Date of Electronic Publication: 2019 Oct 10.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 Subsets: MEDLINE
MeSH Terms :
Glutamine/*analogs & derivatives
Adult ; Aged ; Female ; Glutamine/pharmacokinetics ; Humans ; Male ; Middle Aged ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Glutamine improves heat stress-induced oxidative damage in the broiler thigh muscle by activating the nuclear factor erythroid 2-related 2/Kelch-like ECH-associated protein 1 signaling pathway.
Autorzy :
Hu H; College of Animal Science, Anhui Science and Technology University, Fengyang, 233100 People's Republic of China.
Dai S; College of Animal Science, Anhui Science and Technology University, Fengyang, 233100 People's Republic of China; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
Li J; College of Animal Science, Anhui Science and Technology University, Fengyang, 233100 People's Republic of China.
Wen A; College of Animal Science, Anhui Science and Technology University, Fengyang, 233100 People's Republic of China.
Bai X; College of Animal Science, Anhui Science and Technology University, Fengyang, 233100 People's Republic of China. Electronic address: .
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Źródło :
Poultry science [Poult Sci] 2020 Mar; Vol. 99 (3), pp. 1454-1461. Date of Electronic Publication: 2019 Dec 26.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: England NLM ID: 0401150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3171 (Electronic) Linking ISSN: 00325791 NLM ISO Abbreviation: Poult. Sci. Subsets: MEDLINE
MeSH Terms :
Signal Transduction*
Chickens/*physiology
Glutamine/*metabolism
Heat Stress Disorders/*veterinary
Muscle, Skeletal/*drug effects
Oxidative Stress/*drug effects
Animal Feed/analysis ; Animals ; Avian Proteins/metabolism ; Diet/veterinary ; Dietary Supplements/analysis ; Dose-Response Relationship, Drug ; Female ; Glutamine/administration & dosage ; Heat Stress Disorders/drug therapy ; Kelch-Like ECH-Associated Protein 1/metabolism ; Male ; Meat/analysis ; Muscle, Skeletal/metabolism ; NF-E2-Related Factor 2/metabolism ; Random Allocation ; Thigh
Czasopismo naukowe
Tytuł :
NF-YA overexpression protects from glutamine deprivation.
Autorzy :
Dolfini D; Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy. Electronic address: .
Minuzzo M; Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.
Sertic S; Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.
Mantovani R; Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2020 Feb; Vol. 1867 (2), pp. 118571. Date of Electronic Publication: 2019 Nov 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2596 (Electronic) Linking ISSN: 01674889 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Res Subsets: MEDLINE
MeSH Terms :
CCAAT-Binding Factor/*metabolism
Glutamine/*metabolism
CCAAT-Binding Factor/genetics ; Cell Cycle Checkpoints ; Cell Line, Tumor ; Cell Survival/drug effects ; Endoplasmic Reticulum Stress/genetics ; Gene Expression Regulation/drug effects ; Glutamate-Ammonia Ligase/antagonists & inhibitors ; Glutamate-Ammonia Ligase/metabolism ; Glutamine/deficiency ; Humans ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Thapsigargin/pharmacology ; Transcription Factor CHOP/metabolism
Czasopismo naukowe
Tytuł :
L-glutamine for sickle cell disease: Knight or pawn?
Autorzy :
Sadaf A; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Quinn CT; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
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Źródło :
Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2020 Jan; Vol. 245 (2), pp. 146-154. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Sage Country of Publication: England NLM ID: 100973463 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3699 (Electronic) Linking ISSN: 15353699 NLM ISO Abbreviation: Exp. Biol. Med. (Maywood) Subsets: MEDLINE
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Glutamine/*therapeutic use
Animals ; Clinical Trials as Topic ; Glutamine/metabolism ; Glutamine/pharmacokinetics ; Glutathione/biosynthesis ; Humans ; Intestines/physiology ; Nitric Oxide/biosynthesis
Czasopismo naukowe
Tytuł :
Obesity-linked inflammation tied to glutamine levels.
Autorzy :
Starling S; Nature Reviews Endocrinology, . .
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Źródło :
Nature reviews. Endocrinology [Nat Rev Endocrinol] 2020 Mar; Vol. 16 (3), pp. 130-131.
Typ publikacji :
Journal Article; Comment
Journal Info :
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500078 Publication Model: Print Cited Medium: Internet ISSN: 1759-5037 (Electronic) Linking ISSN: 17595029 NLM ISO Abbreviation: Nat Rev Endocrinol Subsets: MEDLINE
MeSH Terms :
Glutamine*
Obesity*
Adipose Tissue ; Adipose Tissue, White ; Humans ; Inflammation
Czasopismo naukowe
Tytuł :
Tumor Microenvironment, Metabolism, and Immunotherapy.
Autorzy :
DeBerardinis RJ; From the Howard Hughes Medical Institute and Children's Medical Research Institute, University of Texas Southwestern Medical Center, Dallas.
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Źródło :
The New England journal of medicine [N Engl J Med] 2020 Feb 27; Vol. 382 (9), pp. 869-871.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N. Engl. J. Med. Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Immunotherapy*
Tumor Microenvironment*/immunology
Tumor Microenvironment*/physiology
Azo Compounds/*therapeutic use
Caproates/*therapeutic use
Glutamine/*antagonists & inhibitors
Neoplasms/*metabolism
T-Lymphocytes/*drug effects
Animals ; Azo Compounds/pharmacology ; Caproates/pharmacology ; Glutamine/metabolism ; Humans ; Mice ; Neoplasms/immunology ; Neoplasms/therapy ; T-Lymphocytes/physiology
Czasopismo naukowe
Tytuł :
The N-terminal peptide of the transglutaminase-activating metalloprotease inhibitor from Streptomyces mobaraensis accommodates both inhibition and glutamine cross-linking sites.
Autorzy :
Juettner NE; Department of Chemical Engineering and Biotechnology, University of Applied Sciences of Darmstadt, Germany.; Department of Biology, Technische Universität Darmstadt, Germany.
Schmelz S; Structural Biology of Autophagy Group, Department Structure and Function of Proteins, Helmholtz-Centre for Infection Research, Braunschweig, Germany.
Anderl A; Department of Chemical Engineering and Biotechnology, University of Applied Sciences of Darmstadt, Germany.
Colin F; Department of Chemical Engineering and Biotechnology, University of Applied Sciences of Darmstadt, Germany.
Classen M; Department of Chemical Engineering and Biotechnology, University of Applied Sciences of Darmstadt, Germany.
Pfeifer F; Department of Biology, Technische Universität Darmstadt, Germany.
Scrima A; Structural Biology of Autophagy Group, Department Structure and Function of Proteins, Helmholtz-Centre for Infection Research, Braunschweig, Germany.
Fuchsbauer HL; Department of Chemical Engineering and Biotechnology, University of Applied Sciences of Darmstadt, Germany.
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Źródło :
The FEBS journal [FEBS J] 2020 Feb; Vol. 287 (4), pp. 708-720. Date of Electronic Publication: 2019 Aug 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE
MeSH Terms :
Bacterial Proteins/*chemistry
Glutamine/*chemistry
Streptomyces/*enzymology
Transglutaminases/*chemistry
Amino Acid Sequence ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Binding Sites ; Biotinylation ; Cloning, Molecular ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Glutamine/metabolism ; Kinetics ; Models, Molecular ; Point Mutation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Deletion ; Sequence Homology, Amino Acid ; Streptomyces/genetics ; Substrate Specificity ; Transglutaminases/genetics ; Transglutaminases/metabolism
SCR Organism :
Streptomyces mobaraensis
Czasopismo naukowe
Tytuł :
l-glutamine supplementation exerts cardio-renal protection in estrogen-progestin oral contraceptive-treated female rats.
Autorzy :
Olaniyi KS; HOPE Cardiometabolic Research Team & Department of Physiology, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria; Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
Woru Sabinari I; HOPE Cardiometabolic Research Team & Department of Physiology, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria.
Olatunji LA; HOPE Cardiometabolic Research Team & Department of Physiology, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria. Electronic address: .
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Źródło :
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2020 Feb; Vol. 74, pp. 103305. Date of Electronic Publication: 2019 Nov 22.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9612020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7077 (Electronic) Linking ISSN: 13826689 NLM ISO Abbreviation: Environ Toxicol Pharmacol Subsets: MEDLINE
MeSH Terms :
Contraceptives, Oral, Hormonal/*adverse effects
Estrogens/*adverse effects
Glutamine/*administration & dosage
Myocardium/*chemistry
Obesity/*prevention & control
Progestins/*adverse effects
Animals ; Collagen/metabolism ; Contraceptives, Oral, Hormonal/administration & dosage ; Estrogens/administration & dosage ; Female ; Gene Expression Regulation/drug effects ; Glucosephosphate Dehydrogenase/metabolism ; Glutamine/pharmacology ; Lipid Metabolism/drug effects ; Models, Animal ; Obesity/chemically induced ; Progestins/administration & dosage ; Random Allocation ; Rats ; Rats, Wistar ; Xanthine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
The effects of glycine-glutamine dipeptide replaced l-glutamine on bovine parthenogenetic and IVF embryo development.
Autorzy :
Zuo Z; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, PR China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, PR China.
Niu Z; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, PR China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, PR China.
Liu Z; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, PR China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, PR China.
Ma J; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, PR China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, PR China.
Qu P; Laboratory Animal Centre, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, 710061, PR China.
Qiao F; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, PR China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, PR China.
Su J; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, PR China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, PR China.
Zhang Y; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, PR China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, PR China. Electronic address: .
Wang Y; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, PR China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, PR China. Electronic address: .
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Źródło :
Theriogenology [Theriogenology] 2020 Jan 01; Vol. 141, pp. 82-90. Date of Electronic Publication: 2019 Sep 06.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: United States NLM ID: 0421510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3231 (Electronic) Linking ISSN: 0093691X NLM ISO Abbreviation: Theriogenology Subsets: MEDLINE
MeSH Terms :
Cattle/*embryology
Embryo Culture Techniques/*veterinary
Fertilization in Vitro/*veterinary
Glutamine/*chemistry
Glycine/*chemistry
Parthenogenesis/*physiology
Acetylation ; Ammonia/metabolism ; Animals ; Apoptosis ; Culture Media ; Dipeptides/chemistry ; Dipeptides/pharmacology ; Glutamine/pharmacology ; Glycine/pharmacology ; Histones/metabolism ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
High Levels of Glutaminase II Pathway Enzymes in Normal and Cancerous Prostate Suggest a Role in 'Glutamine Addiction'.
Autorzy :
Dorai T; Department of Urology, New York Medical College, Valhalla, NY 10595, USA.; Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.
Dorai B; Department of Pathology, Montefiore-Nyack Hospital, Nyack, NY 10960, USA.
Pinto JT; Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.
Grasso M; Department of Urology, New York Medical College, Valhalla, NY 10595, USA.
Cooper AJL; Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.
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Źródło :
Biomolecules [Biomolecules] 2019 Dec 18; Vol. 10 (1). Date of Electronic Publication: 2019 Dec 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
MeSH Terms :
Amidohydrolases/*metabolism
Glutamine/*metabolism
Ketoglutaric Acids/*metabolism
Lyases/*metabolism
Prostate/*enzymology
Prostatic Neoplasms/*enzymology
Transaminases/*metabolism
Animals ; Glutamine/analysis ; Humans ; Male ; Prostate/metabolism ; Prostatic Neoplasms/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Glutaminolysis and Glycolysis Are Essential for Optimal Replication of Marek's Disease Virus.
Autorzy :
Boodhoo N; The Pirbright Institute, Woking, United Kingdom.; Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.
Kamble N; The Pirbright Institute, Woking, United Kingdom.
Sharif S; Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.
Behboudi S; The Pirbright Institute, Woking, United Kingdom .; Faculty of Health and Medical Sciences, School of Veterinary Medicine, University of Surrey, Guildford, Surrey, United Kingdom.
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Źródło :
Journal of virology [J Virol] 2020 Jan 31; Vol. 94 (4). Date of Electronic Publication: 2020 Jan 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J. Virol. Subsets: MEDLINE
MeSH Terms :
Glucose/*metabolism
Glutamine/*metabolism
Mardivirus/*physiology
Alphaherpesvirinae/metabolism ; Alphaherpesvirinae/physiology ; Animals ; Chick Embryo ; Chickens/virology ; Glucose/physiology ; Glutamine/physiology ; Glycolysis/physiology ; Herpesvirus 2, Gallid/metabolism ; Herpesvirus 2, Gallid/physiology ; Mardivirus/metabolism ; Marek Disease/metabolism ; Marek Disease/virology ; Viral Proteins/metabolism ; Virus Replication/physiology
Czasopismo naukowe
Tytuł :
Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets.
Autorzy :
Verrier ER; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, France.
Weiss A; IGBMC, Plateforme de Criblage Haut-débit, UMR7104 CNRS U1258 Inserm, Illkirch, France.
Bach C; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, France.
Heydmann L; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, France.
Turon-Lagot V; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, France.
Kopp A; IGBMC, Plateforme de Criblage Haut-débit, UMR7104 CNRS U1258 Inserm, Illkirch, France.
El Saghire H; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, France.
Crouchet E; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, France.
Pessaux P; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, France.; Institut Hospitalo-universitaire, Pôle Hépato-digestif, Nouvel Hôpital Civil, Strasbourg, France.
Garcia T; Laboratoire de Synthèse, Réactivité Organiques et Catalyse, Institut de Chimie, UMR 7177 CNRS, Université de Strasbourg, Strasbourg, France.
Pale P; Laboratoire de Synthèse, Réactivité Organiques et Catalyse, Institut de Chimie, UMR 7177 CNRS, Université de Strasbourg, Strasbourg, France.
Zeisel MB; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, France.
Sureau C; INTS, Laboratoire de Virologie Moléculaire, Paris, France.
Schuster C; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, France.
Brino L; IGBMC, Plateforme de Criblage Haut-débit, UMR7104 CNRS U1258 Inserm, Illkirch, France.
Baumert TF; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, France.; Institut Hospitalo-universitaire, Pôle Hépato-digestif, Nouvel Hôpital Civil, Strasbourg, France.; Institut Universitaire de France, Paris, France.
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Źródło :
Gut [Gut] 2020 Jan; Vol. 69 (1), pp. 158-167. Date of Electronic Publication: 2019 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Aspartate Carbamoyltransferase/*genetics
Aspartic Acid/*analogs & derivatives
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)/*genetics
Dihydroorotase/*genetics
Estrogen Receptor alpha/*metabolism
Fulvestrant/*pharmacology
Hepatitis D, Chronic/*drug therapy
Phosphonoacetic Acid/*analogs & derivatives
Pyrimidines/*biosynthesis
Antiviral Agents/pharmacology ; Aspartate Carbamoyltransferase/antagonists & inhibitors ; Aspartate Carbamoyltransferase/metabolism ; Aspartic Acid/pharmacology ; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)/antagonists & inhibitors ; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)/metabolism ; Cell Line ; Dihydroorotase/antagonists & inhibitors ; Dihydroorotase/metabolism ; Estrogen Receptor Antagonists/pharmacology ; Estrogen Receptor alpha/antagonists & inhibitors ; Gene Silencing ; Hepatitis D, Chronic/genetics ; Hepatitis D, Chronic/metabolism ; Hepatitis Delta Virus/physiology ; Hepatocytes ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Insulin Resistance ; Life Cycle Stages ; Loss of Function Mutation ; Phosphonoacetic Acid/pharmacology ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Viral/metabolism ; Signal Transduction ; Virus Replication
Czasopismo naukowe

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