Temat: "Glycine dehydrogenase" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Metabolic Rewiring and Altered Glial Differentiation in an iPSC-Derived Astrocyte Model Derived from a Nonketotic Hyperglycinemia Patient.
Autorzy:: Arribas-Carreira L; Centro de Biología Molecular Severo Ochoa UAM-CSIC, Instituto de Biología Molecular, Departamento de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain.; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), 28049 Madrid, Spain.
Castro M; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), 28049 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 28029 Madrid, Spain.
García F; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), 28049 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 28029 Madrid, Spain.
Navarrete R; Centro de Biología Molecular Severo Ochoa UAM-CSIC, Instituto de Biología Molecular, Departamento de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain.; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), 28049 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 28029 Madrid, Spain.
Bravo-Alonso I; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), 28049 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 28029 Madrid, Spain.
Zafra F; Centro de Biología Molecular Severo Ochoa UAM-CSIC, Instituto de Biología Molecular, Departamento de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain.; Instituto de Investigación Sanitaria Hospital La Paz (IdiPaz), ISCIII, 28029 Madrid, Spain.
Ugarte M; Centro de Biología Molecular Severo Ochoa UAM-CSIC, Instituto de Biología Molecular, Departamento de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain.; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), 28049 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 28029 Madrid, Spain.; Instituto de Investigación Sanitaria Hospital La Paz (IdiPaz), ISCIII, 28029 Madrid, Spain.
Richard E; Centro de Biología Molecular Severo Ochoa UAM-CSIC, Instituto de Biología Molecular, Departamento de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain.; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), 28049 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 28029 Madrid, Spain.; Instituto de Investigación Sanitaria Hospital La Paz (IdiPaz), ISCIII, 28029 Madrid, Spain.
Pérez B; Centro de Biología Molecular Severo Ochoa UAM-CSIC, Instituto de Biología Molecular, Departamento de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain.; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), 28049 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 28029 Madrid, Spain.; Instituto de Investigación Sanitaria Hospital La Paz (IdiPaz), ISCIII, 28029 Madrid, Spain.
Rodríguez-Pombo P; Centro de Biología Molecular Severo Ochoa UAM-CSIC, Instituto de Biología Molecular, Departamento de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain.; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), 28049 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 28029 Madrid, Spain.; Instituto de Investigación Sanitaria Hospital La Paz (IdiPaz), ISCIII, 28029 Madrid, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 28; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:: Journal Article
MeSH Terms:: Hyperglycinemia, Nonketotic*/genetics
Hyperglycinemia, Nonketotic*/pathology
Induced Pluripotent Stem Cells*/pathology
Humans ; Glycine Dehydrogenase (Decarboxylating)/genetics ; Astrocytes/pathology ; Glycine ; Serine

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Skocz do pozycji: 2.

Tytuł:: Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress.
Autorzy:: Jog R; Department of Pathology, Center for Integrative Endocrine and Metabolic Research, Wayne State University School of Medicine, Detroit, MI, USA.
Chen G; Department of Pathology, Center for Integrative Endocrine and Metabolic Research, Wayne State University School of Medicine, Detroit, MI, USA.
Wang J; Department of Pathology, Center for Integrative Endocrine and Metabolic Research, Wayne State University School of Medicine, Detroit, MI, USA.
Leff T; Department of Pathology, Center for Integrative Endocrine and Metabolic Research, Wayne State University School of Medicine, Detroit, MI, USA.; Pokaż więcej
Źródło:: Physiological reports [Physiol Rep] 2021 Aug; Vol. 9 (15), pp. e14991.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Oxidative Stress*
Diabetes Mellitus, Experimental/*pathology
Diabetes Mellitus, Type 2/*pathology
Gene Expression Regulation, Enzymologic/*drug effects
Glucagon/*pharmacology
Glycine/*metabolism
Glycine Dehydrogenase (Decarboxylating)/*metabolism
Animals ; Diabetes Mellitus, Experimental/etiology ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/metabolism ; Gastrointestinal Agents/pharmacology ; Glutathione/metabolism ; Glycine Dehydrogenase (Decarboxylating)/genetics ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Rats ; Rats, Sprague-Dawley

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Skocz do pozycji: 3.

Tytuł:: Mutation analysis of GLDC, AMT and GCSH in cataract captive-bred vervet monkeys (Chlorocebus aethiops).
Autorzy:: Chauke CG; Primate Unit and Delft Animal Centre, South African Medical Research Council, Tygerberg, Cape Town, South Africa.
Magwebu ZE; Primate Unit and Delft Animal Centre, South African Medical Research Council, Tygerberg, Cape Town, South Africa.; Medical Bioscience Department, University of the Western Cape, Bellville, South Africa.
Sharma JR; Biotechnology Department, University of the Western Cape, Bellville, South Africa.
Arieff Z; Biotechnology Department, University of the Western Cape, Bellville, South Africa.
Seier JV; Primate Unit and Delft Animal Centre, South African Medical Research Council, Tygerberg, Cape Town, South Africa.; Pokaż więcej
Źródło:: Journal of medical primatology [J Med Primatol] 2016 Aug; Vol. 45 (4), pp. 189-94. Date of Electronic Publication: 2016 Jun 21.
Typ publikacji:: Journal Article
MeSH Terms:: Chlorocebus aethiops*
Point Mutation*
Aminomethyltransferase/*genetics
Cataract/*veterinary
Glycine Decarboxylase Complex H-Protein/*genetics
Glycine Dehydrogenase/*genetics
Hyperglycinemia, Nonketotic/*veterinary
Monkey Diseases/*genetics
Amino Acid Sequence ; Aminomethyltransferase/chemistry ; Aminomethyltransferase/metabolism ; Animals ; Cataract/genetics ; Glycine Decarboxylase Complex H-Protein/chemistry ; Glycine Decarboxylase Complex H-Protein/metabolism ; Glycine Dehydrogenase/chemistry ; Glycine Dehydrogenase/metabolism ; Hyperglycinemia, Nonketotic/genetics ; Mutation, Missense

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Skocz do pozycji: 4.

Tytuł:: Genomic analyses of glycine decarboxylase neurogenic mutations yield a large-scale prediction model for prenatal disease.
Autorzy:: Farris J; Boler-Parseghian Center for Rare and Neglected Disease, University of Notre Dame, Notre Dame, Indiana, United States of America.; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United State of America.
Alam MS; Boler-Parseghian Center for Rare and Neglected Disease, University of Notre Dame, Notre Dame, Indiana, United States of America.; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United State of America.
Rajashekara AM; Boler-Parseghian Center for Rare and Neglected Disease, University of Notre Dame, Notre Dame, Indiana, United States of America.; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United State of America.
Haldar K; Boler-Parseghian Center for Rare and Neglected Disease, University of Notre Dame, Notre Dame, Indiana, United States of America.; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United State of America.; Pokaż więcej
Źródło:: PLoS genetics [PLoS Genet] 2021 Feb 01; Vol. 17 (2), pp. e1009307. Date of Electronic Publication: 2021 Feb 01 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Disease Models, Animal*
Glycine/*metabolism
Glycine Dehydrogenase (Decarboxylating)/*chemistry
Glycine Dehydrogenase (Decarboxylating)/*genetics
Hyperglycinemia, Nonketotic/*genetics
Animals ; Female ; Genomics ; Genotype ; Glycine/genetics ; Humans ; Hyperglycinemia, Nonketotic/metabolism ; Hyperglycinemia, Nonketotic/pathology ; Male ; Mass Spectrometry ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Mutation, Missense ; Phenotype

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Skocz do pozycji: 5.

Tytuł:: Large scale analyses of genotype-phenotype relationships of glycine decarboxylase mutations and neurological disease severity.
Autorzy:: Farris J; Boler-Parseghian Center for Rare and Neglected Disease, University of Notre Dame, Notre Dame, Indiana, United States of America.; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United State of America.
Calhoun B; Boler-Parseghian Center for Rare and Neglected Disease, University of Notre Dame, Notre Dame, Indiana, United States of America.; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United State of America.
Alam MS; Boler-Parseghian Center for Rare and Neglected Disease, University of Notre Dame, Notre Dame, Indiana, United States of America.; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United State of America.
Lee S; Boler-Parseghian Center for Rare and Neglected Disease, University of Notre Dame, Notre Dame, Indiana, United States of America.; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United State of America.
Haldar K; Boler-Parseghian Center for Rare and Neglected Disease, University of Notre Dame, Notre Dame, Indiana, United States of America.; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United State of America.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2020 May 18; Vol. 16 (5), pp. e1007871. Date of Electronic Publication: 2020 May 18 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Enzymologic*
Genotype*
Mutation, Missense*
Phenotype*
Glycine Dehydrogenase (Decarboxylating)/*genetics
Hyperglycinemia, Nonketotic/*genetics
Humans ; Hyperglycinemia, Nonketotic/diagnosis ; Hyperglycinemia, Nonketotic/pathology ; Severity of Illness Index

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Skocz do pozycji: 6.

Tytuł:: Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase.
Autorzy:: Hasse D; Department of Plant Physiology, University of Rostock, Germany.
Mikkat S
Hagemann M
Bauwe H; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2009 Dec; Vol. 276 (23), pp. 6985-91. Date of Electronic Publication: 2009 Oct 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alternative Splicing/*genetics
Glycine Decarboxylase Complex H-Protein/*chemistry
Glycine Dehydrogenase (Decarboxylating)/*chemistry
Flaveria/enzymology ; Flaveria/genetics ; Flaveria/metabolism ; Glycine Decarboxylase Complex H-Protein/genetics ; Glycine Decarboxylase Complex H-Protein/metabolism ; Glycine Dehydrogenase (Decarboxylating)/genetics ; Glycine Dehydrogenase (Decarboxylating)/metabolism ; Pisum sativum/enzymology ; Pisum sativum/metabolism ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Synechocystis/enzymology ; Synechocystis/metabolism

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Skocz do pozycji: 7.

Tytuł:: A gene expression signature-based nomogram model in prediction of breast cancer bone metastases.
Autorzy:: Zhao C; Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Lou Y; Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Wang Y; Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Wang D; Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Tang L; Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Gao X; Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Zhang K; Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Xu W; Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Liu T; Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Xiao J; Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2019 Jan; Vol. 8 (1), pp. 200-208. Date of Electronic Publication: 2018 Dec 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Models, Genetic*
Bone Neoplasms/*genetics
Breast Neoplasms/*genetics
Aldehyde Oxidoreductases/genetics ; Bone Neoplasms/secondary ; Breast Neoplasms/complications ; DNA-Binding Proteins/genetics ; Female ; Glycine Dehydrogenase (Decarboxylating)/genetics ; Humans ; Keratins, Type I/genetics ; Membrane Transport Proteins/genetics ; Nomograms ; Transcription Factors/genetics ; Transcriptome

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Skocz do pozycji: 8.

Tytuł:: Serum glycine dehydrogenase is associated with increased risk of lung cancer and promotes malignant transformation by regulating DNA methyltransferases expression.
Autorzy:: Wei HY; The Physical and Chemical Laboratory, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong 250062, P.R. China.
Feng R; Radiotherapy Department, Shandong Cancer Hospital and Institute, Jinan, Shandong 250062, P.R. China.
Shao H; The Physical and Chemical Laboratory, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong 250062, P.R. China.
Feng B; The Physical and Chemical Laboratory, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong 250062, P.R. China.
Liu HQ; The Physical and Chemical Laboratory, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong 250062, P.R. China.
Men JL; The Physical and Chemical Laboratory, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong 250062, P.R. China.
Zou W; The Physical and Chemical Laboratory, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong 250062, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2018 Aug; Vol. 18 (2), pp. 2293-2299. Date of Electronic Publication: 2018 Jun 22.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Transformation, Neoplastic/*genetics
DNA Modification Methylases/*genetics
Glycine Dehydrogenase/*blood
Lung Neoplasms/*blood
Aged ; Biomarkers, Tumor/blood ; Body Mass Index ; DNA Methylation/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung/metabolism ; Lung/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Risk Factors ; Signal Transduction/genetics ; Smoking/genetics ; Smoking/pathology

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Skocz do pozycji: 9.

Tytuł:: A novel compound heterozygous variant identified in GLDC gene in a Chinese family with non-ketotic hyperglycinemia.
Autorzy:: Lin Y; Neonatal Disease Screening Center of Quanzhou, Quanzhou Women's and Children's Hospital, 700 Fengze Street, Quanzhou, Fujian Province, 362000, China.
Zheng Z; Neonatal Disease Screening Center of Quanzhou, Quanzhou Women's and Children's Hospital, 700 Fengze Street, Quanzhou, Fujian Province, 362000, China.
Sun W; Genuine Diagnostics Company Limited, 859 Shixiang West Road, Hangzhou, Zhejiang Province, 310007, China. .
Fu Q; Neonatal Disease Screening Center of Quanzhou, Quanzhou Women's and Children's Hospital, 700 Fengze Street, Quanzhou, Fujian Province, 362000, China. .; Pokaż więcej
Źródło:: BMC medical genetics [BMC Med Genet] 2018 Jan 05; Vol. 19 (1), pp. 5. Date of Electronic Publication: 2018 Jan 05.
Typ publikacji:: Journal Article
MeSH Terms:: Heterozygote*
Asian People/*genetics
Glycine Dehydrogenase (Decarboxylating)/*genetics
Hyperglycinemia, Nonketotic/*genetics
Amino Acid Sequence ; China ; Exons ; Female ; Genetic Variation ; Genotype ; Glycine/blood ; Glycine/cerebrospinal fluid ; Humans ; Hyperglycinemia, Nonketotic/enzymology ; Infant, Newborn ; Male ; Mutation, Missense ; Pedigree ; Sequence Deletion ; Siblings

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Skocz do pozycji: 10.

Tytuł:: Osmotic stress response in Acinetobacter baylyi: identification of a glycine-betaine biosynthesis pathway and regulation of osmoadaptive choline uptake and glycine-betaine synthesis through a choline-responsive BetI repressor.
Autorzy:: Scholz A; Department of Molecular Microbiology & Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt, Frankfurt am Main, Germany.
Stahl J; Department of Molecular Microbiology & Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt, Frankfurt am Main, Germany.
de Berardinis V; Genoscope, Institut de Génomique (CEA), Evry, France.
Müller V; Department of Molecular Microbiology & Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt, Frankfurt am Main, Germany.
Averhoff B; Department of Molecular Microbiology & Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt, Frankfurt am Main, Germany.; Pokaż więcej
Źródło:: Environmental microbiology reports [Environ Microbiol Rep] 2016 Apr; Vol. 8 (2), pp. 316-22. Date of Electronic Publication: 2016 Feb 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Bacterial*
Osmoregulation*
Acinetobacter/*physiology
Betaine/*metabolism
Biosynthetic Pathways/*genetics
Choline/*metabolism
Repressor Proteins/*metabolism
Acinetobacter/genetics ; Acinetobacter/metabolism ; Choline Dehydrogenase/genetics ; Choline Dehydrogenase/metabolism ; Electrophoretic Mobility Shift Assay ; Glycine Dehydrogenase/genetics ; Glycine Dehydrogenase/metabolism ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Operon ; Oxidation-Reduction ; Transcription, Genetic

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Skocz do pozycji: 11.

Tytuł:: SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Autorzy:: Kim D; 1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [5] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.
Fiske BP; 1] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [2] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [3] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.
Birsoy K; 1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [5] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.
Freinkman E; 1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [5] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.
Kami K; Human Metabolome Technologies, Inc., Tsuruoka 997-0052, Japan.
Possemato RL; 1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [5] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.
Chudnovsky Y; 1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [5] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.
Pacold ME; 1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [5] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA [6] Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Chen WW; 1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [5] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.
Cantor JR; 1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [5] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.
Shelton LM; Human Metabolome Technologies America, Inc., Boston, Massachusetts 02134, USA.
Gui DY; 1] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [2] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [3] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.
Kwon M; 1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA.
Ramkissoon SH; 1] Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA [3] Department of Pathology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Ligon KL; 1] Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA [3] Department of Pathology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Kang SW; 1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [5] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.
Snuderl M; Department of Pathology, NYU Langone Medical Center and Medical School, New York, New York 10016, USA.
Vander Heiden MG; 1] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [2] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [3] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA [4] Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Sabatini DM; 1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [5] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.; Pokaż więcej
Źródło:: Nature [Nature] 2015 Apr 16; Vol. 520 (7547), pp. 363-7. Date of Electronic Publication: 2015 Apr 08.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain Neoplasms/*metabolism
Brain Neoplasms/*pathology
Glioblastoma/*metabolism
Glioblastoma/*pathology
Glycine/*metabolism
Glycine Hydroxymethyltransferase/*metabolism
Ischemia/*metabolism
Acetone/analogs & derivatives ; Acetone/metabolism ; Acetone/toxicity ; Animals ; Brain Neoplasms/blood supply ; Brain Neoplasms/enzymology ; Cell Hypoxia ; Cell Line, Tumor ; Cell Survival ; Female ; Glioblastoma/blood supply ; Glioblastoma/enzymology ; Glycine Dehydrogenase (Decarboxylating)/antagonists & inhibitors ; Glycine Dehydrogenase (Decarboxylating)/metabolism ; Humans ; Ischemia/enzymology ; Ischemia/pathology ; Mice ; Necrosis ; Oxygen Consumption ; Pyruvaldehyde/metabolism ; Pyruvaldehyde/toxicity ; Pyruvate Kinase/metabolism ; Tumor Microenvironment ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 13.

Tytuł:: Glycine Decarboxylase Expression Increased in p53-Mutated B Cell Lymphoma Mice.
Autorzy:: Li X; Department of Clinical Laboratory Science, Shandong University Affiliated Qianfoshan Hospital, Jinan, China.
Cui C
Guo Y
Yang G; Pokaż więcej
Źródło:: Oncology research and treatment [Oncol Res Treat] 2015; Vol. 38 (11), pp. 586-9. Date of Electronic Publication: 2015 Oct 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Glycine Dehydrogenase (Decarboxylating)/*metabolism
Lymphoma, B-Cell/*enzymology
Lymphoma, B-Cell/*genetics
Tumor Suppressor Protein p53/*genetics
Tumor Suppressor Protein p53/*metabolism
Animals ; Cell Line, Tumor ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mutation/genetics

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 14.

Tytuł:: Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy.
Autorzy:: Azize NA; Molecular Diagnostics and Protein Unit, Specialised Diagnostics Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.
Ngah WZ; UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur, Malaysia.
Othman Z; UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur, Malaysia.
Md Desa N; Molecular Diagnostics and Protein Unit, Specialised Diagnostics Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.
Chin CB; Genetic Department, Kuala Lumpur Hospital, Jalan Pahang, Kuala Lumpur, Malaysia.
Md Yunus Z; Biochemistry Unit, Specialised Diagnostics Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.
Mohan A; Department of Paediatrics, Hospital Bintulu, Sarawak, Malaysia.
Hean TS; Department of Paediatrics, Hospital Miri, Sarawak, Malaysia.
Syed Zakaria SZ; UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur, Malaysia.
Lock-Hock N; Genetic Department, Kuala Lumpur Hospital, Jalan Pahang, Kuala Lumpur, Malaysia.; Pokaż więcej
Źródło:: Journal of human genetics [J Hum Genet] 2014 Nov; Vol. 59 (11), pp. 593-7. Date of Electronic Publication: 2014 Sep 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mutation*
Aminomethyltransferase/*genetics
Genetic Predisposition to Disease/*genetics
Glycine Decarboxylase Complex H-Protein/*genetics
Glycine Dehydrogenase (Decarboxylating)/*genetics
Hyperglycinemia, Nonketotic/*genetics
Base Sequence ; DNA Mutational Analysis/methods ; Family Health ; Female ; Genotype ; Humans ; Infant, Newborn ; Male

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 15.

Tytuł:: Differences in nitrogen metabolism between Cryptococcus neoformans and C. gattii, the two etiologic agents of cryptococcosis.
Autorzy:: Ngamskulrungroj P; Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Chang Y
Roh J
Kwon-Chung KJ; Pokaż więcej
Źródło:: PloS one [PLoS One] 2012; Vol. 7 (3), pp. e34258. Date of Electronic Publication: 2012 Mar 27.
Typ publikacji:: Journal Article; Research Support, N.I.H., Intramural
MeSH Terms:: Cryptococcosis/*microbiology
Cryptococcus gattii/*metabolism
Cryptococcus neoformans/*metabolism
Nitrogen/*metabolism
Animals ; Fungal Proteins/genetics ; GATA Transcription Factors/genetics ; Gene Expression Profiling ; Genetic Complementation Test ; Genome, Fungal/genetics ; Glycine Dehydrogenase (Decarboxylating)/metabolism ; Mice ; Mice, Inbred BALB C ; Models, Biological ; Nitrogen/chemistry ; Quaternary Ammonium Compounds/pharmacology ; Reproducibility of Results ; Species Specificity ; Virulence

Czasopismo naukowe

na półce

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Skocz do pozycji: 16.

Tytuł:: Delivery of a normal baby after preimplantation genetic diagnosis for non-ketotic hyperglycinaemia.
Autorzy:: Hellani A; Saad Specialist Hospital, Al-Khobar, 31952, Kingdom of Saudi Arabia. />Sammour A
Johansson L
El-Sheikh A; Pokaż więcej
Źródło:: Reproductive biomedicine online [Reprod Biomed Online] 2008 Jun; Vol. 16 (6), pp. 893-7.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Preimplantation Diagnosis*
Glycine Dehydrogenase (Decarboxylating)/*genetics
Hyperglycinemia, Nonketotic/*diagnosis
Adult ; Female ; Humans ; Hyperglycinemia, Nonketotic/genetics ; Live Birth ; Male ; Nucleic Acid Amplification Techniques ; Pregnancy

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 17.

Tytuł:: A single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is prevalent among patients with glycine encephalopathy in Jerusalem.
Autorzy:: Boneh A; Department of Human Genetics, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel. .; Metabolic Service, Genetic Health Services Victoria, The Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Melbourne, Victoria, 3052, Australia. .
Korman SH; Department of Clinical Biochemistry, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel.
Sato K; Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan.
Kanno J; Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan.
Matsubara Y; Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan.
Lerer I; Department of Human Genetics, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel.
Ben-Neriah Z; Department of Human Genetics, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel.
Kure S; Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan.; Pokaż więcej
Źródło:: Journal of human genetics [J Hum Genet] 2005; Vol. 50 (5), pp. 230-234. Date of Electronic Publication: 2005 Apr 29.
Typ publikacji:: Journal Article
MeSH Terms:: Point Mutation*
Amino Acid Oxidoreductases/*genetics
Arabs/*genetics
Codon, Initiator/*genetics
Glycine/*metabolism
Hyperglycinemia, Nonketotic/*genetics
Methionine/*genetics
Amino Acid Substitution ; Codon, Initiator/metabolism ; Female ; Glycine Dehydrogenase (Decarboxylating) ; Humans ; Hyperglycinemia, Nonketotic/enzymology ; Israel ; Male ; Pedigree ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Threonine/chemistry ; Threonine/genetics