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Wyszukujesz frazę ""Glycogen Synthase Kinase 3 beta"" wg kryterium: Temat


Tytuł:
27-Hydroxycholesterol activates the GSK-3β/β-catenin signaling pathway resulting in intestinal fibrosis by inducing oxidative stress: effect of dietary interventions.
Autorzy:
Xiao W; The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Hu C; The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Ni Y; The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Wang J; The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Jiao K; Department of Nutrition, The Second Affiliated Hospital, Air Force Medical University, Xi'an, China. .
Zhou M; The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. .
Li Z; The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. .
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Źródło:
Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2024 Feb; Vol. 73 (2), pp. 289-304. Date of Electronic Publication: 2024 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
beta Catenin*/metabolism
Glycogen Synthase Kinase 3 beta*/metabolism
Inflammatory Bowel Diseases*
Oxidative Stress*
Animals ; Humans ; Caco-2 Cells ; Epithelial-Mesenchymal Transition ; Fibrosis ; Hydroxycholesterols/pharmacology ; Inflammation ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł:
Selenium alleviates modafinil-induced neurobehavioral toxicity in rat via PI3K/Akt/mTOR/GSK3B signaling pathway and suppression of oxidative stress and apoptosis: in vivo and in silico study.
Autorzy:
Shehata SA; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Kolieb E; Physiology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Ali DA; Clinical Pharmacology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.; Center of Excellence in Molecular & Cellular Medicine, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Maher SA; Center of Excellence in Molecular & Cellular Medicine, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Korayem HE; Histology and Cell Biology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Ibrahim MA; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt. .; Forensic Medicine and Clinical Toxicology, College of Medicine, Jouf University, 72341, Aljouf, Saudi Arabia. .
Nafie MS; Department of Chemistry, College of Sciences, University of Sharjah, P. O. Box 27272, Sharjah, United Arab Emirates.; Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt.
Ameen SH; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Alsharqia, Egypt.
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Źródło:
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2024 Jan; Vol. 31 (1), pp. 458-480. Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article
MeSH Terms:
Selenium*/pharmacology
Glycogen Synthase Kinase 3 beta*
Humans ; Rats ; Male ; Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Antioxidants/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Modafinil/pharmacology ; Orexins/metabolism ; Orexins/pharmacology ; Molecular Docking Simulation ; Rats, Wistar ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Oxidative Stress ; Inflammation ; Apoptosis ; Neurotransmitter Agents
Czasopismo naukowe
Tytuł:
Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β.
Autorzy:
Harkin EF; Ottawa Hospital Research Institute (Neuroscience), University of Ottawa, 451 Smyth Road, Ottawa, ON K1H-8M5, Canada.
Nasrallah G; Ottawa Hospital Research Institute (Neuroscience), University of Ottawa, 451 Smyth Road, Ottawa, ON K1H-8M5, Canada.
Le François B; Ottawa Hospital Research Institute (Neuroscience), University of Ottawa, 451 Smyth Road, Ottawa, ON K1H-8M5, Canada.
Albert PR; Ottawa Hospital Research Institute (Neuroscience), University of Ottawa, 451 Smyth Road, Ottawa, ON K1H-8M5, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 26; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:
Journal Article
MeSH Terms:
Glycogen Synthase Kinase 3 beta*/genetics
Lithium*/pharmacology
Receptor, Serotonin, 5-HT1A*/genetics
Serotonin*/pharmacology
Humans ; Antidepressive Agents ; HEK293 Cells
Czasopismo naukowe
Tytuł:
GSK3β Inhibition Ameliorates Atherosclerotic Calcification.
Autorzy:
Cai X; Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Zhao Y; Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Yang Y; Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Wu X; Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Zhang L; Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Ma JA; Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Ji J; Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Boström KI; Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.; The Molecular Biology Institute at UCLA, Los Angeles, CA 90095-1570, USA.
Yao Y; Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 19; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 19.
Typ publikacji:
Journal Article
MeSH Terms:
Atherosclerosis*/drug therapy
Atherosclerosis*/genetics
Atherosclerosis*/metabolism
Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors
Glycogen Synthase Kinase 3 beta*/genetics
Vascular Calcification*/drug therapy
Vascular Calcification*/chemically induced
Animals ; Mice ; beta Catenin/genetics ; beta Catenin/metabolism ; Calcification, Physiologic
Czasopismo naukowe
Tytuł:
The ubiquitin ligase HERC4 suppresses MafA transcriptional activity triggered by GSK3β in myeloma by atypical K63-linked polyubiquitination.
Autorzy:
Zhang Z; Jiangsu Key Laboratory for Translational Research and Therapeutics of NeuroPsychoDiseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China. Electronic address: .
Li M; Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Lin P; Jiangsu Key Laboratory for Translational Research and Therapeutics of NeuroPsychoDiseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Ren Y; Jiangsu Key Laboratory for Translational Research and Therapeutics of NeuroPsychoDiseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
He Y; Jiangsu Key Laboratory for Translational Research and Therapeutics of NeuroPsychoDiseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Wang S; Jiangsu Key Laboratory for Translational Research and Therapeutics of NeuroPsychoDiseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Xu Y; Jiangsu Key Laboratory for Translational Research and Therapeutics of NeuroPsychoDiseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Cao B; Jiangsu Key Laboratory for Translational Research and Therapeutics of NeuroPsychoDiseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Wang G; Jiangsu Key Laboratory for Translational Research and Therapeutics of NeuroPsychoDiseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Moran MF; The Department of Molecular Genetics, The University of Toronto, Toronto, Ontario, Canada.
Mao X; Jiangsu Key Laboratory for Translational Research and Therapeutics of NeuroPsychoDiseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China; Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Diseases, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 May; Vol. 299 (5), pp. 104675. Date of Electronic Publication: 2023 Apr 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glycogen Synthase Kinase 3 beta*/metabolism
Maf Transcription Factors, Large*/antagonists & inhibitors
Maf Transcription Factors, Large*/metabolism
Multiple Myeloma*/drug therapy
Multiple Myeloma*/genetics
Multiple Myeloma*/metabolism
Polyubiquitin*/metabolism
Ubiquitin-Protein Ligases*/metabolism
Ubiquitination*
Animals ; Humans ; Mice ; Cell Proliferation ; Dexamethasone/pharmacology ; Lithium Chloride/pharmacology ; Mice, Nude ; Phosphorylation ; STAT3 Transcription Factor/metabolism ; Ubiquitin/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Artificial Protein Crosstalk with a Molecule that Exchanges Binding Partners.
Autorzy:
Suss O; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Halfin O; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Porat Z; Flow Cytometry Unit, Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Fridmann Sirkis Y; Protein Analysis Unit, Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Motiei L; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Margulies D; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, 7610001, Israel.
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Źródło:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Feb 12; Vol. 63 (7), pp. e202312461. Date of Electronic Publication: 2023 Dec 12.
Typ publikacji:
Journal Article
MeSH Terms:
Glycogen Synthase Kinase 3*/metabolism
Signal Transduction*
Protein Serine-Threonine Kinases/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/pharmacology ; Phosphorylation
Czasopismo naukowe
Tytuł:
Gallic acid induces osteoblast differentiation and alleviates inflammatory response through GPR35/GSK3β/β-catenin signaling pathway in human periodontal ligament cells.
Autorzy:
Pham TH; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Kim EN; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Trang NM; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Jeong GS; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
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Źródło:
Journal of periodontal research [J Periodontal Res] 2024 Feb; Vol. 59 (1), pp. 204-219. Date of Electronic Publication: 2023 Nov 13.
Typ publikacji:
Journal Article
MeSH Terms:
Osteogenesis*
Periodontitis*/drug therapy
Periodontitis*/metabolism
Humans ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/pharmacology ; Periodontal Ligament ; beta Catenin/metabolism ; Gallic Acid/pharmacology ; Gallic Acid/metabolism ; Lipopolysaccharides/pharmacology ; Reactive Oxygen Species/metabolism ; Cells, Cultured ; Signal Transduction ; Cell Differentiation ; Anti-Inflammatory Agents/pharmacology ; Receptors, G-Protein-Coupled/metabolism ; Osteoblasts
Czasopismo naukowe
Tytuł:
RCOR1 improves neurobehaviors and neuron injury in rat cerebral palsy by Endothelin-1 targeting-induced Akt/GSK-3β pathway upregulation.
Autorzy:
Xu H; Department of Rehabilitation Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Wulumuqi City, Xinjiang Uygur Autonomous Region 830001, China.
Yu X; Department of Rehabilitation Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Wulumuqi City, Xinjiang Uygur Autonomous Region 830001, China.
Xie R; Department of Rehabilitation Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Wulumuqi City, Xinjiang Uygur Autonomous Region 830001, China.
Wang Y; Department of Rehabilitation Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Wulumuqi City, Xinjiang Uygur Autonomous Region 830001, China.
Li C; Department of Rehabilitation Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Wulumuqi City, Xinjiang Uygur Autonomous Region 830001, China. Electronic address: lichunli_.
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Źródło:
Brain & development [Brain Dev] 2024 Feb; Vol. 46 (2), pp. 93-102. Date of Electronic Publication: 2023 Nov 17.
Typ publikacji:
Journal Article
MeSH Terms:
Cerebral Palsy*/metabolism
Proto-Oncogene Proteins c-akt*
Animals ; Rats ; Apoptosis ; Caspase 3/metabolism ; Caspase 3/pharmacology ; Endothelin-1/metabolism ; Endothelin-1/pharmacology ; Glucose/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/pharmacology ; Neurons/metabolism ; Oxygen ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Reactive Oxygen Species/pharmacology ; Superoxide Dismutase/metabolism ; Superoxide Dismutase/pharmacology ; Up-Regulation
Czasopismo naukowe
Tytuł:
Lithium Chloride Promotes Endogenous Synthesis of CLA in Bovine Mammary Epithelial Cells.
Autorzy:
Liu J; Jilin Provincial Key Laboratory of Livestock and Poultry Feed and Feeding in the Northeastern Frigid Area, College of Animal Sciences, Jilin University, Changchun, 130062, China.
Shen J; Jilin Provincial Key Laboratory of Livestock and Poultry Feed and Feeding in the Northeastern Frigid Area, College of Animal Sciences, Jilin University, Changchun, 130062, China.
Zong J; Jilin Provincial Key Laboratory of Livestock and Poultry Feed and Feeding in the Northeastern Frigid Area, College of Animal Sciences, Jilin University, Changchun, 130062, China.
Fan Y; Jilin Provincial Key Laboratory of Livestock and Poultry Feed and Feeding in the Northeastern Frigid Area, College of Animal Sciences, Jilin University, Changchun, 130062, China.
Cui J; Jilin Provincial Key Laboratory of Livestock and Poultry Feed and Feeding in the Northeastern Frigid Area, College of Animal Sciences, Jilin University, Changchun, 130062, China.
Peng D; Jilin Provincial Key Laboratory of Livestock and Poultry Feed and Feeding in the Northeastern Frigid Area, College of Animal Sciences, Jilin University, Changchun, 130062, China.
Jin Y; Jilin Provincial Key Laboratory of Livestock and Poultry Feed and Feeding in the Northeastern Frigid Area, College of Animal Sciences, Jilin University, Changchun, 130062, China. .
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Źródło:
Biological trace element research [Biol Trace Elem Res] 2024 Feb; Vol. 202 (2), pp. 513-526. Date of Electronic Publication: 2023 Apr 26.
Typ publikacji:
Journal Article
MeSH Terms:
Lithium Chloride*/pharmacology
Lithium Chloride*/analysis
Lithium Chloride*/metabolism
Linoleic Acids, Conjugated*/analysis
Linoleic Acids, Conjugated*/metabolism
Linoleic Acids, Conjugated*/pharmacology
Humans ; Animals ; Cattle ; beta Catenin/metabolism ; Glycogen Synthase Kinase 3 beta/analysis ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/pharmacology ; Mammary Glands, Animal/metabolism ; Milk/chemistry ; Stearoyl-CoA Desaturase ; Epithelial Cells/metabolism ; Fatty Acids/metabolism
Czasopismo naukowe
Tytuł:
FOLR1-stabilized β-catenin promotes laryngeal carcinoma progression through EGFR/AKT/GSK-3β pathway.
Autorzy:
Tuo H; Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Li X; Department of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China.
Du H; Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Li M; Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Xu C; Department of Pathology, School of Basic Medical Science, Hubei University of Medicine, Shiyan, China.
Yu Z; Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Zhao H; Department of Pathology, School of Basic Medical Science, Hubei University of Medicine, Shiyan, China.
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Źródło:
Molecular carcinogenesis [Mol Carcinog] 2024 Jan; Vol. 63 (1), pp. 34-44. Date of Electronic Publication: 2023 Sep 13.
Typ publikacji:
Journal Article
MeSH Terms:
beta Catenin*/genetics
beta Catenin*/metabolism
Head and Neck Neoplasms*
Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Folate Receptor 1 ; Squamous Cell Carcinoma of Head and Neck ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Cell Proliferation/genetics ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
Crocin alleviates neurotoxicity induced by bupivacaine in SH-SY5Y cells with inhibition of PI3K/AKT signaling.
Autorzy:
Lin L; Department of Anesthesiology, Zongrui Hospital of Beilun, Ningbo, 315800, China.
Chen Z; Department of Emergency, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiang'an District, Wuhan, 430014, China.
Li J; Department of Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
Peng J; Department of Cardiovascular Medicine, The Second Affiliated Hospital, Hengyang Medcial School, University of South China, Hengyang, 421099, China.
Wang J; Department of Cardiology, The First Affiliated Hospital of Ningbo University, No.59 Liuting Street, Haishu District, Ningbo, 315010, China.
Feng M; Department of Cardiology, The First Affiliated Hospital of Ningbo University, No.59 Liuting Street, Haishu District, Ningbo, 315010, China.
Liu T; Department of Emergency, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiang'an District, Wuhan, 430014, China.
Zhang M; Department of Emergency, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiang'an District, Wuhan, 430014, China.
Wu X; Department of Emergency, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiang'an District, Wuhan, 430014, China.
Ai F; Department of Emergency, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiang'an District, Wuhan, 430014, China. .
Shen C; Department of Cardiology, The First Affiliated Hospital of Ningbo University, No.59 Liuting Street, Haishu District, Ningbo, 315010, China. .
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Źródło:
Genes & genomics [Genes Genomics] 2024 Jan; Vol. 46 (1), pp. 149-160. Date of Electronic Publication: 2023 Jul 31.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Neuroblastoma*
Carotenoids*
Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Bupivacaine/toxicity ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/pharmacology ; Cell Line, Tumor ; Signal Transduction ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł:
Asperosaponin VI facilitates the regeneration of skeletal muscle injury by suppressing GSK-3β-mediated cell apoptosis.
Autorzy:
Yang X; Department of Pharmacology, Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Liang J; Department of Pediatrics, Guangdong Second Provincial General Hospital, Guangzhou, China.
Shu Y; Department of Pharmacology, Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Wei L; Department of Pharmacology, Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Wen C; Department of Pharmacology, Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Luo H; Department of Pharmacology, Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Ma L; Department of Pharmacology, Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Qin T; Department of Pharmacology, Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Wang B; Department of Cardiovascular Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Zeng S; Department of Pharmacy, Guangdong Second Provincial General Hospital, Guangzhou, China.
Liu Y; Department of Pharmacology, School of Pharmacy, Macau University of Science and Technology, Taipa, Macao, China.; Department of Pharmacology, School of Pharmacy, Guangzhou Xinhua University, Guangzhou, China.
Zhou C; Department of Pharmacology, Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
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Źródło:
Journal of cellular biochemistry [J Cell Biochem] 2024 Jan; Vol. 125 (1), pp. 115-126. Date of Electronic Publication: 2023 Dec 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Muscle, Skeletal*/metabolism
Saponins*/pharmacology
Mice ; Animals ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Apoptosis
Czasopismo naukowe
Tytuł:
Wilforine inhibits rheumatoid arthritis pathology through the Wnt11/β-catenin signaling pathway axis.
Autorzy:
Huang Y; Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, Anhui Province, China.
Peng Y; Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, Anhui Province, China.
Li H; Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, Anhui Province, China.
Li C; Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, Anhui Province, China.
Wu Y; Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, Anhui Province, China.
Wang X; Department of Humanistic Nursing, School of Nursing, Anhui University of Chinese Medicine, Hefei, China. .
Chang J; Department of Orthopaedics, the First Affiliated Hospital, Anhui Medical University, Hefei, 230032, China. changjun_.; Anhui Public Health Clinical Center, Hefei, China. changjun_.
Miao C; Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, Anhui Province, China. .
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Źródło:
Arthritis research & therapy [Arthritis Res Ther] 2023 Dec 14; Vol. 25 (1), pp. 243. Date of Electronic Publication: 2023 Dec 14.
Typ publikacji:
Journal Article
MeSH Terms:
Arthritis, Rheumatoid*/metabolism
Synoviocytes*/metabolism
Arthritis, Experimental*/metabolism
Rats ; Animals ; beta Catenin/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/pharmacology ; Cell Proliferation ; Wnt Signaling Pathway ; Fibroblasts/metabolism ; Cells, Cultured ; Synovial Membrane/metabolism ; Wnt Proteins/metabolism
Czasopismo naukowe
Tytuł:
NRF1 knockdown alleviates lipopolysaccharide-induced pulmonary inflammatory injury by upregulating DKK3 and inhibiting the GSK-3β/β-catenin pathway.
Autorzy:
Kang L; Department of Pediatrics, Neonatal Intensive Care Unit, Zhumadian Central Hospital, Zhumadian, Henan Province, China.
Wang X; Department of Pediatrics, Neonatal Intensive Care Unit, Zhumadian Central Hospital, Zhumadian, Henan Province, China.
Wang J; Department of Clinical Laboratory, Zhumadian Central Hospital, Zhumadian, Henan Province, China.
Guo J; Department of Pediatrics, Neonatal Intensive Care Unit, Henan Children's Hospital, Zhengzhou, Henan Province, China.
Zhang W; Department of Pediatrics, Neonatal Intensive Care Unit, Zhumadian Central Hospital, Zhumadian, Henan Province, China.
Lei R; Department of Neonatology, Zhumadian Central Hospital, Zhumadian, Henan Province, China.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2023 Dec 11; Vol. 214 (1), pp. 120-129.
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*
Pneumonia*
Infant, Newborn ; Humans ; Lipopolysaccharides ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/pharmacology ; beta Catenin/genetics ; beta Catenin/metabolism ; beta Catenin/pharmacology ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-6/metabolism ; Reactive Oxygen Species/metabolism ; Apoptosis/genetics ; Adaptor Proteins, Signal Transducing/genetics
Czasopismo naukowe
Tytuł:
Neuroprotection and Mechanism of Gas-miR36-5p from Gastrodia elata in an Alzheimer's Disease Model by Regulating Glycogen Synthase Kinase-3β.
Autorzy:
Lu Z; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Fu J; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Wu G; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Yang Z; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Wu X; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Wang D; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
You Z; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Nie Z; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Sheng Q; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 09; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Gastrodia*/genetics
Neuroprotective Agents*/pharmacology
Neuroprotective Agents*/therapeutic use
Neurodegenerative Diseases*
MicroRNAs*/metabolism
Animal Diseases*
Mice ; Animals ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; tau Proteins/metabolism ; Neuroprotection ; Phosphorylation
Czasopismo naukowe
Tytuł:
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.
Autorzy:
Cui L; Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, Guangdong, China. .
Lu Y; Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Zheng J; Department of Dentistry, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Guo B; Department of Dentistry, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Zhao X; Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, Guangdong, China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Dec 07; Vol. 42 (1), pp. 335. Date of Electronic Publication: 2023 Dec 07.
Typ publikacji:
Journal Article
MeSH Terms:
Cisplatin*/pharmacology
Head and Neck Neoplasms*/drug therapy
Head and Neck Neoplasms*/genetics
Animals ; Humans ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/genetics ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism ; Integrin beta1/metabolism ; Phosphorylation ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Actinin/genetics ; Actinin/metabolism ; Cell Line, Tumor ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic ; Cell Proliferation ; Myosin Heavy Chains/genetics ; Myosin Heavy Chains/metabolism
Czasopismo naukowe
Tytuł:
Rg1 alleviates oxidative stress and spermatogonium apoptosis in D-gal-induced testicular toxicity by activating Akt.
Autorzy:
Wang Z; Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
Du K; Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
Hou J; Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
Xiao H; Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
Hu L; Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
Chen X; Department of Anatomy and Histology and Embryology, Basic Medical College, Chengdu University of Traditional Chinese Medicine, Sichuan, People's Republic of China.
Wang L; Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
Wang Y; Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
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Źródło:
Redox report : communications in free radical research [Redox Rep] 2023 Dec; Vol. 28 (1), pp. 2206197.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Testis*/metabolism
Animals ; Male ; Mice ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Apoptosis ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/pharmacology ; Mice, Inbred C57BL ; Oxidative Stress ; Spermatogonia/metabolism
Czasopismo naukowe
Tytuł:
Wheat germ peptide improves glucose metabolism and insulin resistance in HepG2 hepatocytes via regulating SOCS3/IRS1/Akt pathway.
Autorzy:
Song H; College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China. Electronic address: .
Huang Q; College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China.
Zhang Y; College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China.
Shen X; College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China. Electronic address: .
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Źródło:
Nutrition research (New York, N.Y.) [Nutr Res] 2023 Dec; Vol. 120, pp. 135-144. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Insulin Resistance*
Humans ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/pharmacology ; Triticum ; Insulin Receptor Substrate Proteins/metabolism ; Hexokinase/metabolism ; Hexokinase/pharmacology ; Pyruvate Kinase/metabolism ; Phosphoenolpyruvate/metabolism ; Phosphoenolpyruvate/pharmacology ; Hepatocytes/metabolism ; Glucose/metabolism ; Insulin/metabolism ; Glycogen/metabolism ; Suppressor of Cytokine Signaling 3 Protein/metabolism
Czasopismo naukowe
Tytuł:
P25/CDK5-mediated Tau Hyperphosphorylation in Both Ipsilateral and Contralateral Cerebra Contributes to Cognitive Deficits in Post-stroke Mice.
Autorzy:
Yu J; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China.
Zhao Y; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
Gong XK; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
Liang Z; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
Zhao YN; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China.
Li X; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China.
Chen YJ; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China.
Yang YH; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China.
Wu MJ; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China.
Wang XC; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Shu XJ; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. .; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China. .
Bao J; Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. .; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China. .
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Źródło:
Current medical science [Curr Med Sci] 2023 Dec; Vol. 43 (6), pp. 1084-1095. Date of Electronic Publication: 2023 Nov 04.
Typ publikacji:
Journal Article
MeSH Terms:
Cerebrum*/metabolism
Cognitive Dysfunction*/etiology
Animals ; Humans ; Mice ; Cognition ; Cyclin-Dependent Kinase 5/genetics ; Cyclin-Dependent Kinase 5/metabolism ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; HEK293 Cells ; Ischemia ; tau Proteins/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł:
ZBTB20-AS1 promoted Alzheimer's disease progression through ZBTB20/GSK-3β/Tau pathway.
Autorzy:
Wang Y; Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Zhejiang, 310013, China.
Cai M; Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Zhejiang, 310013, China.
Lou Y; Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Zhejiang, 310013, China.
Zhang S; Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Zhejiang, 310013, China.
Liu X; Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Zhejiang, 310013, China. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Jan 15; Vol. 640, pp. 88-96. Date of Electronic Publication: 2022 Dec 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Glycogen Synthase Kinase 3 beta*/genetics
Glycogen Synthase Kinase 3 beta*/metabolism
MicroRNAs*/genetics
Nerve Tissue Proteins*/metabolism
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
tau Proteins*/metabolism
Humans ; Apoptosis ; Cell Line, Tumor ; Transcription Factors
Czasopismo naukowe

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