- Tytuł :
- Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
- Autorzy :
- Źródło :
- Nature communications [Nat Commun] 2021 Feb 05; Vol. 12 (1), pp. 836. Date of Electronic Publication: 2021 Feb 05.
- Typ publikacji :
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- MeSH Terms :
-
Colitis/*genetics
Glycogen Synthase Kinase 3 beta /*genetics
Homeostasis/*genetics
Interleukin-33/*genetics
Membrane Proteins/*genetics
Protein-Serine-Threonine Kinases/*genetics
Animals ; Cell Count ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Child ; Colitis/chemically induced ; Colitis/metabolism ; Colitis/pathology ; Colon/drug effects ; Colon/metabolism ; Colon/pathology ; Female ; Gene Expression Regulation ;Glycogen Synthase Kinase 3 beta /metabolism ; Goblet Cells/drug effects ; Goblet Cells/metabolism ; Goblet Cells/pathology ; HT29 Cells ; Homeostasis/drug effects ; Humans ; Interleukin-33/metabolism ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Phosphatidylinositol3 -Kinases/genetics ; Phosphatidylinositol3 -Kinases/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Sodium Dodecyl Sulfate/administration & dosage -
Czasopismo naukowe