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Wyszukujesz frazę ""Glycogen Synthase Kinase 3 beta"" wg kryterium: Temat


Tytuł:
MIF/SCL3A2 depletion inhibits the proliferation and metastasis of colorectal cancer cells via the AKT/GSK-3β pathway and cell iron death.
Autorzy:
Huang G; Department of Pathology, Nanfang Hospital and School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.; Department of Pathology, Shenzhen Longgang Central Hospital, Shenzhen, China.
Ma L; Department of Pathology, Nanfang Hospital and School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Shen L; Department of Pathology, Nanfang Hospital and School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Lei Y; Department of Pathology, Nanfang Hospital and School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Guo L; Department of Pathology, Nanfang Hospital and School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Deng Y; Department of Pathology, Nanfang Hospital and School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China.
Ding Y; Department of Pathology, Nanfang Hospital and School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China.
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Źródło:
Journal of cellular and molecular medicine [J Cell Mol Med] 2022 Jun; Vol. 26 (12), pp. 3410-3422. Date of Electronic Publication: 2022 May 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/metabolism
Colorectal Neoplasms*/pathology
Glycogen Synthase Kinase 3 beta*/genetics
Glycogen Synthase Kinase 3 beta*/metabolism
Iron*/metabolism
Macrophage Migration-Inhibitory Factors*/genetics
Macrophage Migration-Inhibitory Factors*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Animals ; Cell Death ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Mice ; Signal Transduction
Czasopismo naukowe
Tytuł:
Development of inhibitors targeting glycogen synthase kinase-3β for human diseases: Strategies to improve selectivity.
Autorzy:
Wei J; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Wang J; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, 38163, Tennessee, United States.
Zhang J; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yang J; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Wang G; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: .
Wang Y; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Jun 05; Vol. 236, pp. 114301. Date of Electronic Publication: 2022 Mar 31.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors
Neoplasms*/drug therapy
Humans
Czasopismo naukowe
Tytuł:
Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy.
Autorzy:
Su PP; Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Research Institutes of Nephropathy, Zhengzhou University, Zhengzhou, 450052, China.; Department of Nephrology and Rheumatology, the Third People's Hospital of Zhengzhou, Zhengzhou, 450002, China.; Henan Province Research Center for Kidney Disease, Zhengzhou, 450052, China.; Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, 450002, China.
Liu DW; Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Research Institutes of Nephropathy, Zhengzhou University, Zhengzhou, 450052, China.; Henan Province Research Center for Kidney Disease, Zhengzhou, 450052, China.; Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, 450002, China.
Zhou SJ; Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Research Institutes of Nephropathy, Zhengzhou University, Zhengzhou, 450052, China.; Henan Province Research Center for Kidney Disease, Zhengzhou, 450052, China.; Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, 450002, China.
Chen H; Department of Nephrology and Rheumatology, the Third People's Hospital of Zhengzhou, Zhengzhou, 450002, China.
Wu XM; Department of Nephrology and Rheumatology, the Third People's Hospital of Zhengzhou, Zhengzhou, 450002, China.
Liu ZS; Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Research Institutes of Nephropathy, Zhengzhou University, Zhengzhou, 450052, China. .; Henan Province Research Center for Kidney Disease, Zhengzhou, 450052, China. .; Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, 450002, China. .
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Źródło:
Military Medical Research [Mil Med Res] 2022 May 26; Vol. 9 (1), pp. 23. Date of Electronic Publication: 2022 May 26.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus*
Diabetic Nephropathies*/genetics
Diabetic Nephropathies*/metabolism
Glycogen Synthase Kinase 3 beta*/genetics
Glycogen Synthase Kinase 3 beta*/metabolism
Glycogen Synthase Kinase 3 beta*/pharmacology
Podocytes*/metabolism
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
RNA, Long Noncoding*/pharmacology
Sirtuin 1*/genetics
Sirtuin 1*/metabolism
Sirtuin 1*/pharmacology
Animals ; Autophagy/genetics ; Down-Regulation ; Mice
Czasopismo naukowe
Tytuł:
Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β.
Autorzy:
Shi XC; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Xia B; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Zhang JF; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Zhang RX; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Zhang DY; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Liu H; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Xie BC; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Wang YL; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Wu JW; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
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Źródło:
PLoS biology [PLoS Biol] 2022 Apr 27; Vol. 20 (4), pp. e3001619. Date of Electronic Publication: 2022 Apr 27 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy*
Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
Glycogen Synthase Kinase 3 beta*/genetics
Glycogen Synthase Kinase 3 beta*/metabolism
Membrane Transport Proteins*/genetics
Membrane Transport Proteins*/metabolism
Muscle Development*/genetics
Wnt Signaling Pathway*/genetics
Animals ; Cell Differentiation/genetics ; Mice ; Muscle, Skeletal/metabolism
Czasopismo naukowe
Tytuł:
ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradation.
Autorzy:
Lorenzoni M; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy.
De Felice D; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy.
Beccaceci G; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy.
Di Donato G; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy.
Foletto V; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy.
Genovesi S; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy.
Bertossi A; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy.
Cambuli F; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy.
Lorenzin F; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy.
Savino A; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Avalle L; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Cimadamore A; Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, Ancona, Italy.
Montironi R; Molecular Medicine and Cell Therapy Foundation, Polytechnic University of the Marche Region, Via Tronto, 10, Ancona, Italy.
Weber V; Unit of Surgical Pathology, Santa Chiara Hospital, Trento, Italy.
Carbone FG; Unit of Surgical Pathology, Santa Chiara Hospital, Trento, Italy.
Barbareschi M; Unit of Surgical Pathology, Santa Chiara Hospital, Trento, Italy.
Demichelis F; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy.
Romanel A; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy.
Poli V; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Del Sal G; University of Trieste Department Life Sciences, ICGEB-Area Science Park Trieste, IFOM, Milan, Italy.
Julio MK; Urology Research Laboratory, Department for BioMedical Research DBMR, University of Bern, Bern, Switzerland; Translational Organoid Resource CORE, Department for BioMedical Research, University of Bern, Bern, Switzerland; Bern Center for Precision Medicine, Inselspital, University Hospital of Bern, Bern, Switzerland; Department of Urology, Inselspital, University Hospital of Bern, Bern, Switzerland.
Gaspari M; Research Centre for Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy. Electronic address: .
Alaimo A; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy. Electronic address: .
Lunardi A; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, Trento, Italy. Electronic address: .
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Źródło:
Cancer letters [Cancer Lett] 2022 May 28; Vol. 534, pp. 215612. Date of Electronic Publication: 2022 Mar 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glycogen Synthase Kinase 3 beta*/genetics
Homeodomain Proteins*/genetics
Prostate*/pathology
Prostatic Neoplasms*/pathology
Transcription Factors*/genetics
Transcriptional Regulator ERG*/genetics
Animals ; Genomic Instability ; Male ; Mice ; Oncogene Proteins ; Trans-Activators/metabolism
Czasopismo naukowe
Tytuł:
ABCB6 knockdown suppresses melanogenesis through the GSK3-β/β-catenin signaling axis in human melanoma and melanocyte cell lines.
Autorzy:
She Q; Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dong Y; Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li D; Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
An R; Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhou T; Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Nie X; Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Pan R; Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Deng Y; Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
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Źródło:
Journal of dermatological science [J Dermatol Sci] 2022 May; Vol. 106 (2), pp. 101-110. Date of Electronic Publication: 2022 Apr 12.
Typ publikacji:
Journal Article
MeSH Terms:
ATP-Binding Cassette Transporters*/genetics
ATP-Binding Cassette Transporters*/metabolism
Glycogen Synthase Kinase 3 beta*/metabolism
Melanins*/metabolism
Melanocytes*/metabolism
Melanoma*/genetics
Melanoma*/metabolism
Melanoma*/pathology
beta Catenin*/metabolism
Catenins/metabolism ; Cell Line ; Humans ; Microphthalmia-Associated Transcription Factor/genetics ; Microphthalmia-Associated Transcription Factor/metabolism ; Monophenol Monooxygenase/genetics ; Monophenol Monooxygenase/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.
Autorzy:
Zhou Z; Department of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated Guangren Hospital, School of Medicine, Xi'an Jiaotong University, 21 Jiefang Road, Xi'an, Shaanxi, 710004, PR China.
Li H; Department of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated Guangren Hospital, School of Medicine, Xi'an Jiaotong University, 21 Jiefang Road, Xi'an, Shaanxi, 710004, PR China. Electronic address: li_.
Bai S; Department of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated Guangren Hospital, School of Medicine, Xi'an Jiaotong University, 21 Jiefang Road, Xi'an, Shaanxi, 710004, PR China.
Xu Z; Department of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated Guangren Hospital, School of Medicine, Xi'an Jiaotong University, 21 Jiefang Road, Xi'an, Shaanxi, 710004, PR China.
Jiao Y; Department of Endocrinology, The Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710000, PR China.
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Apr 16; Vol. 600, pp. 87-93. Date of Electronic Publication: 2022 Feb 12.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetic Retinopathy*/metabolism
Diabetic Retinopathy*/pathology
Glycogen Synthase Kinase 3 beta*/metabolism
Intracellular Signaling Peptides and Proteins*/metabolism
NF-E2-Related Factor 2*/metabolism
Protein Serine-Threonine Kinases*
Proto-Oncogene Proteins c-akt*/metabolism
Retinal Ganglion Cells*/metabolism
Retinal Ganglion Cells*/pathology
Apoptosis ; GA-Binding Protein Transcription Factor/metabolism ; Glucose/administration & dosage ; Glucose/metabolism ; Humans ; Oxidative Stress ; Signal Transduction
Czasopismo naukowe
Tytuł:
Naringin attenuates acute myocardial ischemia-reperfusion injury via miR- 126/GSK-3β/β-catenin signaling pathway.
Autorzy:
Guo X; MD. Department of Price Office of Finance - The Second Hospital - Cheeloo College of Medicine - Shandong University - Shandong Province, China.
Ji Q; MD. Department of Obstetrics - The Second Hospital - Cheeloo College of Medicine - Shandong University - Shandong Province, China.
Wu M; MD. Department of Ultrasonography - The Second Hospital - Cheeloo College of Medicine - Shandong University - Shandong Province, China.
Ma W; MD. Department of Ultrasonography - The Second Hospital - Cheeloo College of Medicine - Shandong University - Shandong Province, China.
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Źródło:
Acta cirurgica brasileira [Acta Cir Bras] 2022 Apr 08; Vol. 37 (1), pp. e370102. Date of Electronic Publication: 2022 Apr 08 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Flavanones*/pharmacology
Glycogen Synthase Kinase 3 beta*/metabolism
MicroRNAs*/metabolism
Myocardial Infarction*
Myocardial Reperfusion Injury*/drug therapy
Myocardial Reperfusion Injury*/metabolism
Myocardial Reperfusion Injury*/prevention & control
beta Catenin*/metabolism
Animals ; Apoptosis ; Rats ; Signal Transduction
Czasopismo naukowe
Tytuł:
NAD ameliorates endotoxin-induced acute kidney injury in a sirtuin1-dependent manner via GSK-3β/Nrf2 signalling pathway.
Autorzy:
He S; School of Medicine, Nankai University, Tianjin, China.
Gao Q; Tianjin key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, China.
Wu X; School of Medicine, Nankai University, Tianjin, China.
Shi J; Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, China.
Zhang Y; Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, China.
Yang J; Tianjin key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, China.
Li X; Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, China.
Du S; Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, China.
Zhang Y; Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, China.
Yu J; School of Medicine, Nankai University, Tianjin, China.; Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, China.
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Źródło:
Journal of cellular and molecular medicine [J Cell Mol Med] 2022 Apr; Vol. 26 (7), pp. 1979-1993. Date of Electronic Publication: 2022 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Acute Kidney Injury*/metabolism
Glycogen Synthase Kinase 3 beta*/metabolism
NAD*/metabolism
NF-E2-Related Factor 2*/metabolism
Sirtuin 1*/genetics
Sirtuin 1*/metabolism
Endotoxins ; Humans ; Oxidative Stress
Czasopismo naukowe
Tytuł:
Cardiomyocyte-GSK-3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms.
Autorzy:
Yusuf AM; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, UAE.; Cardiovascular Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.
Qaisar R; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, UAE.; Cardiovascular Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.
Al-Tamimi AO; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, UAE.; Cardiovascular Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.
Jayakumar MN; Cardiovascular Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.
Woodgett JR; Department of Medical Biophysics, Sinai Health System, Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada.
Koch WJ; Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Ahmad F; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, UAE.; Cardiovascular Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.; Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
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Źródło:
Journal of cellular physiology [J Cell Physiol] 2022 Mar; Vol. 237 (3), pp. 1804-1817. Date of Electronic Publication: 2021 Nov 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Myocardial Infarction*/metabolism
Myocytes, Cardiac*/metabolism
Glycogen Synthase Kinase 3 beta/*metabolism
Animals ; Cell Proliferation/genetics ; Glycogen Synthase Kinase 3 beta/genetics ; Mice ; Vascular Endothelial Growth Factor A/metabolism ; Ventricular Remodeling/genetics
Czasopismo naukowe
Tytuł:
HMGA1 stimulates MYH9-dependent ubiquitination of GSK-3β via PI3K/Akt/c-Jun signaling to promote malignant progression and chemoresistance in gliomas.
Autorzy:
Que T; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; Nanfang Glioma Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Zheng H; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Zeng Y; Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Liu X; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; The First Clinical Medical School, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Qi G; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
La Q; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Liang T; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; The First Clinical Medical School, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Li Z; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; Nanfang Glioma Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Yi G; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; Nanfang Glioma Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Zhang S; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Li J; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Nie J; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Tan JE; Nanfang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China. .
Huang G; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China. .; The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China. .; Nanfang Glioma Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China. .
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Źródło:
Cell death & disease [Cell Death Dis] 2021 Dec 10; Vol. 12 (12), pp. 1147. Date of Electronic Publication: 2021 Dec 10.
Typ publikacji:
Journal Article
MeSH Terms:
Glioma*/drug therapy
Glioma*/genetics
Glycogen Synthase Kinase 3 beta*/genetics
Glycogen Synthase Kinase 3 beta*/metabolism
HMGA1a Protein*/genetics
HMGA1a Protein*/metabolism
Myosin Heavy Chains*/genetics
Myosin Heavy Chains*/metabolism
Cell Proliferation/genetics ; Drug Resistance, Neoplasm/genetics ; Humans ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Ubiquitination ; beta Catenin/genetics ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł:
A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis.
Autorzy:
Blaha CS; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Ramakrishnan G; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Jeon SM; College of Pharmacy, Ajou University Yeongtong-gu, Suwon-si, Gyeonggi-do, 443-749, Korea. .
Nogueira V; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Rho H; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Kang S; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Bhaskar P; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Terry AR; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Aissa AF; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Frolov MV; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Patra KC; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45267-0521, USA.
Brooks Robey R; Veterans Affairs Medical Center, White River Junction, Hartford, VT, 05009, USA.; Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.
Hay N; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA. .; Research & Development Section, Jesse Brown VA Medical Center, Chicago, IL, 60612, USA. .
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Źródło:
Nature communications [Nat Commun] 2022 Feb 16; Vol. 13 (1), pp. 899. Date of Electronic Publication: 2022 Feb 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Glucose/*metabolism
Glycogen Synthase Kinase 3 beta/*metabolism
Hexokinase/*metabolism
Neoplasms/*pathology
A Kinase Anchor Proteins/metabolism ; A549 Cells ; Animals ; CHO Cells ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cricetulus ; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit/metabolism ; Deoxyglucose/pharmacology ; Epithelial-Mesenchymal Transition/physiology ; Female ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Glycosylation ; HCT116 Cells ; HEK293 Cells ; Hexokinase/genetics ; Humans ; Mice ; Mice, Inbred BALB C ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; NF-E2-Related Factor 2/metabolism ; Neoplasm Metastasis/pathology ; Phosphorylation/drug effects ; Rats ; Snail Family Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Effect of l-carnitine supplementation on lead acetate-induced liver cell apoptosis and inflammation: role of caspase-3 and glycogen synthase kinase-3β enzymes.
Autorzy:
Abdel-Emam RA; Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt. Electronic address: .
Ali MF; Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2022 Feb 15; Vol. 291, pp. 120277. Date of Electronic Publication: 2021 Dec 31.
Typ publikacji:
Journal Article
MeSH Terms:
Carnitine/*pharmacology
Caspase 3/*metabolism
Glycogen Synthase Kinase 3 beta/*metabolism
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Carnitine/metabolism ; Caspase 3/physiology ; Dietary Supplements ; Glycogen Synthase Kinase 3 beta/physiology ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Inflammation/metabolism ; Liver/drug effects ; Liver/pathology ; Male ; Organometallic Compounds/adverse effects ; Organometallic Compounds/pharmacology ; Oxidative Stress/drug effects ; Phosphorylation/drug effects ; Rats ; Rats, Wistar ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
Age-related GSK3β overexpression drives podocyte senescence and glomerular aging.
Autorzy:
Fang Y; Division of Nephrology, Department of Medicine and.; Center for Hypertension and Precision Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA.; Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chen B; Division of Nephrology, Department of Medicine and.; Division of Kidney Disease and Hypertension, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Liu Z; Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Gong AY; Division of Nephrology, Department of Medicine and.
Gunning WT; Department of Pathology and.
Ge Y; Division of Nephrology, Department of Medicine and.
Malhotra D; Division of Nephrology, Department of Medicine and.
Gohara AF; Department of Pathology and.
Dworkin LD; Division of Nephrology, Department of Medicine and.; Center for Hypertension and Precision Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA.; Division of Kidney Disease and Hypertension, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Gong R; Division of Nephrology, Department of Medicine and.; Center for Hypertension and Precision Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA.; Division of Kidney Disease and Hypertension, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.; Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, Ohio, USA.
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Źródło:
The Journal of clinical investigation [J Clin Invest] 2022 Feb 15; Vol. 132 (4).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*
Aging/*metabolism
Glycogen Synthase Kinase 3 beta/*biosynthesis
Podocytes/*enzymology
Adult ; Aging/genetics ; Animals ; Female ; Gene Expression Regulation, Enzymologic ; Glycogen Synthase Kinase 3 beta/genetics ; Humans ; Male ; Mice ; Mice, Knockout ; Middle Aged
Czasopismo naukowe
Tytuł:
Structure-Based design of Marine-derived Meridianin C derivatives as glycogen synthase kinase 3β inhibitors with improved oral bioavailability: From aminopyrimidyl-indoles to the sulfonyl analogues.
Autorzy:
Han S; Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.
Zhou W; Department of Chemistry, Fudan University, Shanghai 200438, China.
Zhuang C; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.
Chen F; Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2022 Feb; Vol. 119, pp. 105537. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glycogen Synthase Kinase 3 beta/*antagonists & inhibitors
Indoles/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Administration, Oral ; Animals ; Biological Availability ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Glycogen Synthase Kinase 3 beta/metabolism ; Indoles/administration & dosage ; Indoles/chemistry ; Indoles/metabolism ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/metabolism ; Pyrimidines/administration & dosage ; Pyrimidines/metabolism ; Rats ; Structure-Activity Relationship ; Urochordata/chemistry
Czasopismo naukowe
Tytuł:
Design, synthesis, in vitro antiproliferative evaluation and GSK-3β kinase inhibition of a new series of pyrimidin-4-one based amide conjugates.
Autorzy:
Khan I; Department of Chemistry, School of Chemical and Life Sciences (SCLS), Jamia Hamdard, New Delhi 110 062, India.
Tantray MA; Chemistry Research Lab, Department of Chemistry, Govt. Degree College Baramulla, J&K 193103, India.
Hamid H; Department of Chemistry, School of Chemical and Life Sciences (SCLS), Jamia Hamdard, New Delhi 110 062, India. Electronic address: .
Sarwar Alam M; Department of Chemistry, School of Chemical and Life Sciences (SCLS), Jamia Hamdard, New Delhi 110 062, India.
Sharma K; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110 062, India.
Kesharwani P; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110 062, India.
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2022 Feb; Vol. 119, pp. 105512. Date of Electronic Publication: 2021 Nov 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Design*
Amides/*pharmacology
Antineoplastic Agents/*pharmacology
Glycogen Synthase Kinase 3 beta/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Amides/chemical synthesis ; Amides/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Anti-Inflammatory Effect of IKK-Activated GSK-3β Inhibitory Peptide Prevented Nigrostriatal Neurodegeneration in the Rodent Model of Parkinson's Disease.
Autorzy:
Lee S; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.; Research Institute for Drug Development, Pusan National University, Busan 46241, Korea.
Hong DG; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.; Research Institute for Drug Development, Pusan National University, Busan 46241, Korea.
Yang S; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.; Research Institute for Drug Development, Pusan National University, Busan 46241, Korea.
Kim J; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.; Research Institute for Drug Development, Pusan National University, Busan 46241, Korea.
Baek M; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.; Research Institute for Drug Development, Pusan National University, Busan 46241, Korea.
Kim S; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.; Research Institute for Drug Development, Pusan National University, Busan 46241, Korea.
Thirumalai D; Department of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan 46241, Korea.
Chung HY; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.; Research Institute for Drug Development, Pusan National University, Busan 46241, Korea.
Chang SC; Department of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan 46241, Korea.
Lee J; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.; Research Institute for Drug Development, Pusan National University, Busan 46241, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 17; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 17.
Typ publikacji:
Journal Article
MeSH Terms:
Glycogen Synthase Kinase 3 beta/*metabolism
I-kappa B Kinase/*metabolism
Parkinson Disease/*drug therapy
Peptides/*administration & dosage
Animals ; Disease Models, Animal ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; HCT116 Cells ; Humans ; Lipopolysaccharides/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Peptides/pharmacology ; RAW 264.7 Cells ; Tumor Necrosis Factor-alpha/pharmacology
Czasopismo naukowe
Tytuł:
siRNA Mediated GSK3β Knockdown Targets Insulin Signaling Pathway and Rescues Alzheimer's Disease Pathology: Evidence from In Vitro and In Vivo Studies.
Autorzy:
Gupta S; Department of Biochemistry, Panjab University, Chandigarh 160014, India.
Singh V; National Agri-Food Biotechnology Institute, Sector 81, S.A.S. Nagar, Mohali 140306, Punjab, India.
Ganesh S; Department of Biological Science and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
Singhal NK; National Agri-Food Biotechnology Institute, Sector 81, S.A.S. Nagar, Mohali 140306, Punjab, India.
Sandhir R; Department of Biochemistry, Panjab University, Chandigarh 160014, India.
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Źródło:
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2022 Jan 12; Vol. 14 (1), pp. 69-93. Date of Electronic Publication: 2021 Dec 30.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease/*drug therapy
Drug Carriers/*chemistry
Glycogen Synthase Kinase 3 beta/*metabolism
Nanostructures/*chemistry
RNA, Small Interfering/*therapeutic use
Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid/metabolism ; Animals ; Brain/drug effects ; Brain/pathology ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/pathology ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/complications ; Gene Knockdown Techniques ; Glycogen Synthase Kinase 3 beta/genetics ; Graphite/chemistry ; MAP Kinase Signaling System/drug effects ; Maze Learning/drug effects ; Memory/drug effects ; Polyethylene Glycols/chemistry ; Rats ; Receptor, Insulin/metabolism ; Streptozocin
Czasopismo naukowe
Tytuł:
Ginsenoside-Rg1 attenuates sepsis-induced cardiac dysfunction by modulating mitochondrial damage via the P2X7 receptor-mediated Akt/GSK-3β signaling pathway.
Autorzy:
Liu Z; Cardiology Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.; Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Pan H; Cardiology Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.; Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Zhang Y; Emergency Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Zheng Z; Cardiology Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.; Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Xiao W; Emergency Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Hong X; Department of Research, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Chen F; Emergency Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Peng X; Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Pei Y; Emergency Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Rong J; Cardiology Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.; Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
He J; Cardiology Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.; Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Zou L; Hunan Provincial Key Laboratory of Emergency and Critical Care Metabolomics, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Wang J; Department of Research, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Zhong J; Department of Research, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Han X; Emergency Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Cao Y; Emergency Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
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Źródło:
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2022 Jan; Vol. 36 (1), pp. e22885. Date of Electronic Publication: 2021 Dec 02.
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*
Ginsenosides/*pharmacology
Glycogen Synthase Kinase 3 beta/*metabolism
Heart Diseases/*metabolism
Mitochondria, Heart/*metabolism
Myocytes, Cardiac/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Receptors, Purinergic P2X7/*metabolism
Sepsis/*metabolism
Animals ; Cell Line ; Glycogen Synthase Kinase 3 beta/genetics ; Heart Diseases/genetics ; Mice ; Mitochondria, Heart/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Rats ; Receptors, Purinergic P2X7/genetics ; Sepsis/genetics
Czasopismo naukowe
Tytuł:
Propofol inhibits oxidative stress injury through the glycogen synthase kinase 3 beta/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling pathway.
Autorzy:
Zhang Z; Department of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.
Yan B; Department of Anesthesiology, Fifth Medical Center of Chinese Pla General Hospital, Beijing, China.
Li Y; Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.
Yang S; Department of Medical Administration, The Eleventh People's Hospital of Guangzhou, Guangdong, China.
Li J; Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.
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Źródło:
Bioengineered [Bioengineered] 2022 Jan; Vol. 13 (1), pp. 1612-1625.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms:
Glycogen Synthase Kinase 3 beta/*metabolism
Heme Oxygenase (Decyclizing)/*metabolism
Myocardial Reperfusion Injury/*metabolism
NF-E2-Related Factor 2/*metabolism
Oxidative Stress/*drug effects
Propofol/*pharmacology
Signal Transduction/*drug effects
Animals ; Cell Line ; Glycogen Synthase Kinase 3 beta/genetics ; Heme Oxygenase (Decyclizing)/genetics ; Male ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/genetics ; NF-E2-Related Factor 2/genetics ; Oxidative Stress/genetics ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/genetics
Czasopismo naukowe

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