Temat: "Glycogen Synthase Kinase 3 beta" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
Autorzy :: Schumacher MA; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Department of Pediatrics and Department of Biochemistry and Molecular Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Hsieh JJ; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Department of Pediatrics and Department of Biochemistry and Molecular Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Liu CY; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Appel KL; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Waddell A; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Almohazey D; Department of Stem Cell Research, Institute for Research and Medical Consultation (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Katada K; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Bernard JK; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Bucar EB; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Department of Pediatrics and Department of Biochemistry and Molecular Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Gadeock S; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Maselli KM; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Washington MK; Departments of Pathology, Microbiology, and Immunology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Grikscheit TC; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Warburton D; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Rosen MJ; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Frey MR; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA. .; Department of Pediatrics and Department of Biochemistry and Molecular Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. .; Pokaż więcej
Źródło :: Nature communications [Nat Commun] 2021 Feb 05; Vol. 12 (1), pp. 836. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Colitis/*genetics
Glycogen Synthase Kinase 3 beta/*genetics
Homeostasis/*genetics
Interleukin-33/*genetics
Membrane Proteins/*genetics
Protein-Serine-Threonine Kinases/*genetics
Animals ; Cell Count ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Child ; Colitis/chemically induced ; Colitis/metabolism ; Colitis/pathology ; Colon/drug effects ; Colon/metabolism ; Colon/pathology ; Female ; Gene Expression Regulation ; Glycogen Synthase Kinase 3 beta/metabolism ; Goblet Cells/drug effects ; Goblet Cells/metabolism ; Goblet Cells/pathology ; HT29 Cells ; Homeostasis/drug effects ; Humans ; Interleukin-33/metabolism ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Sodium Dodecyl Sulfate/administration & dosage
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Evidence that knock down of GSK-3β in Chronic Myelogenous Leukemia cells augments IFN-γ-induced apoptosis.
Autorzy :: Kauffman MR; Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH 45701, USA; Biomedical Engineering Program, Ohio University, Athens, OH 45701, USA.
Nazemidashtarjandi S; Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH 45701, USA.
Ghazanfari D; Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH 45701, USA.
Allen AE; Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH 45701, USA; Biomedical Engineering Program, Ohio University, Athens, OH 45701, USA.
Reynolds NM; Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH 45701, USA; Translational Biomedical Sciences Program, Ohio University, Athens, OH 45701, USA.
Faik A; Environmental and Plant Biology Department, Ohio University, Athens, OH 45701, USA; Molecular and Cellular Biology Program, Ohio University, Athens, OH 45701, USA.
Burdick MM; Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH 45701, USA; Biomedical Engineering Program, Ohio University, Athens, OH 45701, USA; Molecular and Cellular Biology Program, Ohio University, Athens, OH 45701, USA; Translational Biomedical Sciences Program, Ohio University, Athens, OH 45701, USA.
McCall KD; Biomedical Engineering Program, Ohio University, Athens, OH 45701, USA; Molecular and Cellular Biology Program, Ohio University, Athens, OH 45701, USA; Translational Biomedical Sciences Program, Ohio University, Athens, OH 45701, USA; Department of Specialty Medicine, Ohio University, Athens, OH 45701, USA; The Diabetes Institute, Ohio University, Athens, OH 45701, USA.
Goetz DJ; Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH 45701, USA; Biomedical Engineering Program, Ohio University, Athens, OH 45701, USA; Molecular and Cellular Biology Program, Ohio University, Athens, OH 45701, USA; Translational Biomedical Sciences Program, Ohio University, Athens, OH 45701, USA. Electronic address: .; Pokaż więcej
Źródło :: Leukemia research [Leuk Res] 2020 Dec; Vol. 99, pp. 106464. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :: Apoptosis/*drug effects
Glycogen Synthase Kinase 3 beta/*antagonists & inhibitors
Interferon-gamma/*pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Neoplasm Proteins/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Antineoplastic Agents/pharmacology ; CRISPR-Cas Systems ; Cell Adhesion/drug effects ; Cell Line, Tumor/drug effects ; Codon, Nonsense ; Drug Interactions ; Flow Cytometry ; Frameshift Mutation ; Fusion Proteins, bcr-abl/antagonists & inhibitors ; Gene Knockdown Techniques ; Glycogen Synthase Kinase 3 beta/genetics ; Humans ; Interferon-gamma/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/enzymology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Male ; RNA, Guide/genetics ; RNA, Guide/pharmacology ; Spectrometry, Fluorescence
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Glycogen synthase kinase-3β participates in acquired resistance to gemcitabine in pancreatic cancer.
Autorzy :: Uehara M; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Domoto T; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Takenaka S; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Bolidong D; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Takeuchi O; Biomedical Laboratory, Department of Research, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Miyashita T; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.; Department of Surgical Oncology, Kanazawa Medical University, Ishikawa, Japan.
Minamoto T; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.; Pokaż więcej
Źródło :: Cancer science [Cancer Sci] 2020 Dec; Vol. 111 (12), pp. 4405-4416. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :: Journal Article
MeSH Terms :: Drug Resistance, Neoplasm*
Antimetabolites, Antineoplastic/*pharmacology
Deoxycytidine/*analogs & derivatives
Glycogen Synthase Kinase 3 beta/*physiology
Pancreatic Neoplasms/*drug therapy
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cyclin D1/metabolism ; Deoxycytidine/pharmacology ; E2F1 Transcription Factor/metabolism ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Heterografts ; Humans ; Mice ; Mice, Nude ; Pancreatic Neoplasms/metabolism ; Phosphorylation ; Retinoblastoma Protein/metabolism ; Ribonucleoside Diphosphate Reductase/metabolism ; Thymidine Kinase/metabolism ; Thymidylate Synthase/metabolism ; Transcription, Genetic
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: Control of neuronal excitability by GSK-3beta: Epilepsy and beyond.
Autorzy :: Jaworski T; Laboratory of Animal Models, Nencki Institute of Experimental Biology, Warsaw, Poland. Electronic address: .; Pokaż więcej
Źródło :: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2020 Sep; Vol. 1867 (9), pp. 118745. Date of Electronic Publication: 2020 May 23.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :: Electrophysiological Phenomena*
Glycogen Synthase Kinase 3 beta/*genetics
Glycogen Synthase Kinase 3 beta/*metabolism
Neurons/*physiology
Animals ; Brain/metabolism ; Brain/physiopathology ; Brain Waves ; Disease Models, Animal ; Disease Susceptibility ; Drug Development ; Epilepsy/diagnosis ; Epilepsy/drug therapy ; Epilepsy/etiology ; Epilepsy/metabolism ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Humans ; Ion Channels/metabolism ; Molecular Targeted Therapy ; Signal Transduction
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Sirtuin inhibits M. tuberculosis -induced apoptosis in macrophage through glycogen synthase kinase-3β.
Autorzy :: Yang H; Department of Microbiology and Immunology, Tongji University School of Medicine, Shanghai, 200092, China; Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China; Shanghai TB Key Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China. Electronic address: .
Chen J; Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China; Shanghai TB Key Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China.
Chen Y; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.
Jiang Y; Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China; Shanghai TB Key Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China.
Ge B; Department of Microbiology and Immunology, Tongji University School of Medicine, Shanghai, 200092, China; Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China; Shanghai TB Key Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China.
Hong L; Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China. Electronic address: .; Pokaż więcej
Źródło :: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Nov 15; Vol. 694, pp. 108612. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Apoptosis/*drug effects
Glycogen Synthase Kinase 3 beta/*metabolism
Macrophages/*drug effects
Mycobacterium tuberculosis/*pathogenicity
Sirtuin 1/*metabolism
Animals ; Enzyme Activators/pharmacology ; Female ; Glycogen Synthase Kinase 3 beta/chemistry ; HEK293 Cells ; Humans ; Macrophages/metabolism ; Macrophages/microbiology ; Mice ; Mycobacterium tuberculosis/drug effects ; Phosphorylation/drug effects ; Resveratrol/pharmacology ; Signal Transduction/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Development of an immunogenomic landscape for the competing endogenous RNAs network of peri-implantitis.
Autorzy :: Li Y; Department of Stomatology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China.; State key laboratory of molecular engineering of polymers, Fudan University, Shanghai, P.R. China.
Zheng J; Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
Gong C; Department of Stomatology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China.
Lan K; Department of Stomatology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China.
Shen Y; Department of Stomatology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China. .
Ding X; Department of Stomatology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China. .; State key laboratory of molecular engineering of polymers, Fudan University, Shanghai, P.R. China. .; Pokaż więcej
Źródło :: BMC medical genetics [BMC Med Genet] 2020 Oct 20; Vol. 21 (1), pp. 208. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :: Journal Article
MeSH Terms :: Glycogen Synthase Kinase 3 beta/*genetics
MicroRNAs/*genetics
Peri-Implantitis/*genetics
RNA, Long Noncoding/*genetics
RNA, Messenger/*genetics
Case-Control Studies ; Databases, Genetic ; Datasets as Topic ; Dental Implants/adverse effects ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Ontology ; Gene Regulatory Networks ; Glycogen Synthase Kinase 3 beta/immunology ; Humans ; Immunity, Innate ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Macrophages/immunology ; Macrophages/pathology ; Mast Cells/immunology ; Mast Cells/pathology ; MicroRNAs/classification ; MicroRNAs/immunology ; Peri-Implantitis/etiology ; Peri-Implantitis/immunology ; Peri-Implantitis/pathology ; RNA, Long Noncoding/classification ; RNA, Long Noncoding/immunology ; RNA, Messenger/classification ; RNA, Messenger/immunology ; T Follicular Helper Cells/immunology ; T Follicular Helper Cells/pathology
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 7 7.

Tytuł :: Intranasal insulin ameliorates cognitive impairment in a rat model of Parkinson's disease through Akt/GSK3β signaling pathway.
Autorzy :: Yang L; Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Zhang X; Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Li S; Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Wang H; Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Zhang X; Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Liu L; Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Xie A; Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: .; Pokaż więcej
Źródło :: Life sciences [Life Sci] 2020 Oct 15; Vol. 259, pp. 118159. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :: Journal Article
MeSH Terms :: Cognitive Dysfunction/*drug therapy
Cognitive Dysfunction/*etiology
Glycogen Synthase Kinase 3 beta/*drug effects
Hypoglycemic Agents/*therapeutic use
Insulin/*therapeutic use
Oncogene Protein v-akt/*drug effects
Parkinson Disease/*complications
Signal Transduction/*drug effects
Administration, Intranasal ; Animals ; Brain/pathology ; Cognitive Dysfunction/psychology ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/pathology ; Glycogen Synthase Kinase 3 beta/metabolism ; Hypoglycemic Agents/administration & dosage ; Insulin/administration & dosage ; Male ; Maze Learning/drug effects ; Parkinson Disease/psychology ; Rats ; Rats, Wistar
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Ubiquinol-cytochrome c reductase core protein 1 overexpression protects H9c2 cardiac cells against mimic ischemia/reperfusion injury through PI3K/Akt/GSK-3β pathway.
Autorzy :: Yi T; Department of Anesthesiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China; Department of Anesthesiology, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China.
Wu X; Department of Anesthesiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China; Department of Intensive Care Unit, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, 610072, China.
Li H; Department of Anesthesiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. Electronic address: .; Pokaż więcej
Źródło :: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Sep 03; Vol. 529 (4), pp. 904-909. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Electron Transport Complex III/*genetics
Glycogen Synthase Kinase 3 beta/*genetics
Myocytes, Cardiac/*metabolism
Oxygen/*pharmacology
Phosphatidylinositol 3-Kinases/*genetics
Proto-Oncogene Proteins c-akt/*genetics
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Caspase 3/genetics ; Caspase 3/metabolism ; Cell Line ; Chromones/pharmacology ; Electron Transport Complex III/metabolism ; Embryo, Mammalian ; Gene Expression Regulation ; Glucose/deficiency ; Glucose/pharmacology ; Glycogen Synthase Kinase 3 beta/metabolism ; Hydrogen Peroxide/pharmacology ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Models, Biological ; Morpholines/pharmacology ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Signal Transduction ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Potential therapeutic effect of targeting glycogen synthase kinase 3β in esophageal squamous cell carcinoma.
Autorzy :: Bolidong D; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-0934, Japan.
Domoto T; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-0934, Japan.
Uehara M; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-0934, Japan.
Sabit H; Department of Neurosurgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Okumura T; Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Endo Y; Central Research Resource Branch, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Nakada M; Department of Neurosurgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Ninomiya I; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Miyashita T; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.; Department of Surgical Oncology, Kanazawa Medical University Hospital, Ishikawa, Japan.
Wong RW; WPI Nano Life Science Institute, Kanazawa University, Kanazawa, Japan.
Minamoto T; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-0934, Japan. .; Pokaż więcej
Źródło :: Scientific reports [Sci Rep] 2020 Jul 16; Vol. 10 (1), pp. 11807. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Antineoplastic Agents/*pharmacology
Esophageal Neoplasms/*metabolism
Esophageal Squamous Cell Carcinoma/*metabolism
Glycogen Synthase Kinase 3 beta/*antagonists & inhibitors
Adult ; Aged ; Animals ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Biomarkers, Tumor ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Disease Models, Animal ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Squamous Cell Carcinoma/genetics ; Esophageal Squamous Cell Carcinoma/pathology ; Female ; Gene Expression ; Glycogen/metabolism ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Male ; Mice ; Middle Aged ; Molecular Targeted Therapy ; Neoplasm Metastasis ; Neoplasm Staging ; Phosphorylation ; Xenograft Model Antitumor Assays
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 10 10.

Tytuł :: Glycogen Synthase Kinase-3β Mediates Proinflammatory Cytokine Secretion and Adipogenesis in Orbital Fibroblasts from Patients with Graves' Orbitopathy.
Autorzy :: Lee JS; .
Chae MK; .
Kikkawa DO; .
Lee EJ; .
Yoon JS; .; Pokaż więcej
Źródło :: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2020 Jul 01; Vol. 61 (8), pp. 51.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Graves Ophthalmopathy*/drug therapy
Graves Ophthalmopathy*/immunology
Graves Ophthalmopathy*/metabolism
Inflammation*/drug therapy
Inflammation*/metabolism
Orbit*/immunology
Orbit*/metabolism
Orbit*/pathology
Adipogenesis/*drug effects
Glycogen Synthase Kinase 3 beta/*metabolism
Pyridines/*pharmacology
Pyrimidines/*pharmacology
Adipocytes/metabolism ; Anti-Inflammatory Agents/pharmacology ; Cell Differentiation/drug effects ; Cells, Cultured ; Chemokine CCL2/metabolism ; Cyclooxygenase 1/metabolism ; Cytokines/biosynthesis ; Cytokines/metabolism ; Fibroblasts/metabolism ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Humans
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Identification of Schistosoma japonicum GSK3β interacting partners by yeast two-hybrid screening and its role in parasite survival.
Autorzy :: Liu J; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, 518 Ziyue Road, Shanghai, 200241, China.
Li H; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, 518 Ziyue Road, Shanghai, 200241, China.
Xia T; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, 518 Ziyue Road, Shanghai, 200241, China.
Du P; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, 518 Ziyue Road, Shanghai, 200241, China.
Giri B; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, 518 Ziyue Road, Shanghai, 200241, China.
Li X; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, 518 Ziyue Road, Shanghai, 200241, China.
Li X; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, 518 Ziyue Road, Shanghai, 200241, China.
Cheng G; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, 518 Ziyue Road, Shanghai, 200241, China. .; Tongji University of School of Medicine, #1239 Si-Ping Road, Shanghai, 200092, China. .; Pokaż więcej
Źródło :: Parasitology research [Parasitol Res] 2020 Jul; Vol. 119 (7), pp. 2217-2226. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :: Journal Article
MeSH Terms :: Glycogen Synthase Kinase 3 beta/*metabolism
Helminth Proteins/*metabolism
Schistosoma japonicum/*metabolism
Animals ; Female ; Gene Expression Regulation ; Glycogen Synthase Kinase 3 beta/genetics ; Helminth Proteins/genetics ; Male ; Protein Binding ; RNA Interference ; Schistosoma japonicum/enzymology ; Schistosoma japonicum/genetics ; Survival Analysis ; Two-Hybrid System Techniques
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Ultrasound therapy with optimal intensity facilitates peripheral nerve regeneration in rats through suppression of pro-inflammatory and nerve growth inhibitor gene expression.
Autorzy :: Ito A; Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Wang T; Department of Development and Rehabilitation of Motor Function, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nakahara R; Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kawai H; Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nishitani K; Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Aoyama T; Department of Development and Rehabilitation of Motor Function, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kuroki H; Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Pokaż więcej
Źródło :: PloS one [PLoS One] 2020 Jun 17; Vol. 15 (6), pp. e0234691. Date of Electronic Publication: 2020 Jun 17 (Print Publication: 2020).
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Gene Expression Regulation*
Nerve Regeneration*/genetics
Ultrasonic Therapy*
Glycogen Synthase Kinase 3 beta/*genetics
Peripheral Nerve Injuries/*physiopathology
Peripheral Nerve Injuries/*therapy
Semaphorin-3A/*genetics
Animals ; Cytokines/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Inflammation Mediators/metabolism ; Male ; Myelin Sheath/metabolism ; Nerve Crush ; Peripheral Nerve Injuries/diagnostic imaging ; Peripheral Nerve Injuries/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Inbred Lew ; Sciatic Nerve/injuries ; Sciatic Nerve/pathology ; Sciatic Nerve/physiopathology ; Sciatic Nerve/ultrastructure ; Semaphorin-3A/metabolism
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 13 13.

Tytuł :: Evaluating the Activity of Sodium Butyrate to Prevent Osteoporosis in Rats by Promoting Osteal GSK-3β/Nrf2 Signaling and Mitochondrial Function.
Autorzy :: Tang X; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Ma S; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Li Y; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Sun Y; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China.
Zhang K; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu 214122, China.
Zhou Q; Department of Neonatology, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, China.
Yu R; Department of Neonatology, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, China.; Pokaż więcej
Źródło :: Journal of agricultural and food chemistry [J Agric Food Chem] 2020 Jun 17; Vol. 68 (24), pp. 6588-6603. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :: Journal Article
MeSH Terms :: Butyric Acid/*administration & dosage
Glycogen Synthase Kinase 3 beta/*metabolism
Mitochondria/*drug effects
NF-E2-Related Factor 2/*metabolism
Osteoporosis/*drug therapy
Adenosine Triphosphate/metabolism ; Animals ; Female ; Glycogen Synthase Kinase 3 beta/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/genetics ; Mitochondria/metabolism ; NF-E2-Related Factor 2/genetics ; Osteoporosis/genetics ; Osteoporosis/metabolism ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 14 14.

Tytuł :: VHL mutation-mediated SALL4 overexpression promotes tumorigenesis and vascularization of clear cell renal cell carcinoma via Akt/GSK-3β signaling.
Autorzy :: Sun J; Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi, China.
Tang Q; Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi, China.
Gao Y; Department of Respiratory and Critical Care Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi, China.
Zhang W; Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi, China.
Zhao Z; Clinical Laboratory, The 986th Military Hospital, Fourth Military Medical University, Xi'an, 710054, Shaanxi, China.
Yang F; Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi, China.
Hu X; Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi, China.
Zhang D; Department of Pathology, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, 710018, Shaanxi, China.
Wang Y; Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi, China.
Zhang H; Medical Laboratory and Research Center, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi, China.
Song B; Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi, China. .
Zhang B; Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi, China. .
Wang H; Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi, China. .; Pokaż więcej
Źródło :: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2020 Jun 08; Vol. 39 (1), pp. 104. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :: Journal Article
MeSH Terms :: Mutation*
Carcinoma, Renal Cell/*pathology
Glycogen Synthase Kinase 3 beta/*metabolism
Kidney Neoplasms/*pathology
Proto-Oncogene Proteins c-akt/*metabolism
Transcription Factors/*metabolism
Von Hippel-Lindau Tumor Suppressor Protein/*genetics
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Renal Cell/blood supply ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Cell Proliferation ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Glycogen Synthase Kinase 3 beta/genetics ; Humans ; Kidney Neoplasms/blood supply ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Male ; Mice ; Mice, Nude ; Middle Aged ; Neoplasm Invasiveness ; Neovascularization, Pathologic ; Prognosis ; Proto-Oncogene Proteins c-akt/genetics ; Signal Transduction ; Survival Rate ; Transcription Factors/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 15 15.

Tytuł :: The effect of dual inhibition of Ras-MEK-ERK and GSK3β pathways on development of in vitro cultured rabbit embryos.
Autorzy :: Bontovics B; NARIC, Agricultural Biotechnology Institute, Animal Biotechnology Department, 2100Gödöllő, Szent-Györgyi A. str. 4., Hungary.
Maraghechi P; NARIC, Agricultural Biotechnology Institute, Animal Biotechnology Department, 2100Gödöllő, Szent-Györgyi A. str. 4., Hungary.
Lázár B; NARIC, Agricultural Biotechnology Institute, Animal Biotechnology Department, 2100Gödöllő, Szent-Györgyi A. str. 4., Hungary.
Anand M; NARIC, Agricultural Biotechnology Institute, Animal Biotechnology Department, 2100Gödöllő, Szent-Györgyi A. str. 4., Hungary.
Németh K; NARIC, Agricultural Biotechnology Institute, Animal Biotechnology Department, 2100Gödöllő, Szent-Györgyi A. str. 4., Hungary.; Department of Laboratory Medicine, Semmelweis University, 1088Budapest, Szentkiralyi str. 46, Hungary.
Fábián R; NARIC, Agricultural Biotechnology Institute, Animal Biotechnology Department, 2100Gödöllő, Szent-Györgyi A. str. 4., Hungary.
Vašíček J; Research Institute for Animal Production Nitra, NPPC, Hlohovecka 2, 951 41Lužianky, Slovak Republic.; Faculty of Biotechnology and Food Science, Slovak University of Agriculture, Hlinku 2, 949 76, Nitra, Slovak Republic.
Makarevich AV; Research Institute for Animal Production Nitra, NPPC, Hlohovecka 2, 951 41Lužianky, Slovak Republic.
Gócza E; NARIC, Agricultural Biotechnology Institute, Animal Biotechnology Department, 2100Gödöllő, Szent-Györgyi A. str. 4., Hungary.
Chrenek P; Research Institute for Animal Production Nitra, NPPC, Hlohovecka 2, 951 41Lužianky, Slovak Republic.; Faculty of Biotechnology and Food Science, Slovak University of Agriculture, Hlinku 2, 949 76, Nitra, Slovak Republic.; Faculty of Animal Breeding and Biology, UTP University of Science and Technology, Mazowiecka 28, 85-084Bydgoszcz, Poland.; Pokaż więcej
Źródło :: Zygote (Cambridge, England) [Zygote] 2020 Jun; Vol. 28 (3), pp. 183-190. Date of Electronic Publication: 2020 Mar 20.
Typ publikacji :: Journal Article
MeSH Terms :: Embryo, Mammalian/*metabolism
Embryonic Development/*drug effects
Glycogen Synthase Kinase 3 beta/*metabolism
MAP Kinase Signaling System/*drug effects
Mitogen-Activated Protein Kinase Kinases/*metabolism
ras Proteins/*metabolism
Amides/pharmacology ; Animals ; Benzamides/pharmacology ; Diphenylamine/analogs & derivatives ; Diphenylamine/pharmacology ; Embryo Culture Techniques ; Embryo, Mammalian/cytology ; Embryo, Mammalian/embryology ; Enzyme Inhibitors/pharmacology ; Female ; Germ Layers/cytology ; Germ Layers/drug effects ; Germ Layers/metabolism ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; Pyrimidines/pharmacology ; Rabbits ; Thiosemicarbazones/pharmacology ; ras Proteins/antagonists & inhibitors
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: HDAC8 promotes the dissemination of breast cancer cells via AKT/GSK-3β/Snail signals.
Autorzy :: An P; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangdong, 510006, China.
Chen F; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangdong, 510006, China.
Li Z; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangdong, 510006, China.
Ling Y; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangdong, 510006, China.
Peng Y; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangdong, 510006, China.
Zhang H; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangdong, 510006, China.
Li J; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangdong, 510006, China.
Chen Z; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China. .
Wang H; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangdong, 510006, China. .; Pokaż więcej
Źródło :: Oncogene [Oncogene] 2020 Jun; Vol. 39 (26), pp. 4956-4969. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Breast Neoplasms/*genetics
Glycogen Synthase Kinase 3 beta/*genetics
Histone Deacetylases/*genetics
Proto-Oncogene Proteins c-akt/*genetics
Repressor Proteins/*genetics
Signal Transduction/*genetics
Snail Family Transcription Factors/*genetics
Animals ; Breast Neoplasms/metabolism ; Breast Neoplasms/therapy ; Cell Line, Tumor ; Cell Movement/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Glycogen Synthase Kinase 3 beta/metabolism ; Histone Deacetylases/metabolism ; Humans ; Kaplan-Meier Estimate ; Mice, Nude ; Proto-Oncogene Proteins c-akt/metabolism ; Repressor Proteins/metabolism ; Snail Family Transcription Factors/metabolism ; Xenograft Model Antitumor Assays/methods
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: Recovery of muscle mass and muscle oxidative phenotype following disuse does not require GSK-3 inactivation.
Autorzy :: Theeuwes WF; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, the Netherlands.
Pansters NAM; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, the Netherlands.
Gosker HR; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, the Netherlands.
Schols AMWJ; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, the Netherlands.
Verhees KJP; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, the Netherlands.
de Theije CC; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, the Netherlands.
van Gorp RHP; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, the Netherlands.
Kelders MCJM; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, the Netherlands.
Ronda O; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, the Netherlands.
Haegens A; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, the Netherlands.
Remels AHV; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Pharmacology and Toxicology, Maastricht University Medical Center+, Maastricht, the Netherlands.
Langen RCJ; NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, the Netherlands. Electronic address: .; Pokaż więcej
Źródło :: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2020 Jun 01; Vol. 1866 (6), pp. 165740. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Glycogen Synthase Kinase 3 beta/*genetics
Muscle Development/*genetics
Muscular Atrophy/*drug therapy
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*genetics
Animals ; Glycogen Synthase Kinase 3/genetics ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Hindlimb Suspension ; Humans ; Mice ; Mitochondria/genetics ; Mitochondria/metabolism ; Muscle Proteins/genetics ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscular Atrophy/genetics ; Muscular Atrophy/metabolism ; Muscular Atrophy/pathology ; Oxidative Phosphorylation/drug effects ; Phenotype ; Quality of Life ; Signal Transduction/drug effects ; Transcription Factors/genetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Glycogen synthase kinase-3β (GSK-3β) of grass carp (Ctenopharyngodon idella): Synteny, structure, tissue distribution and expression in oleic acid (OA)-induced adipocytes and hepatocytes.
Autorzy :: Bian C; College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling 712100, China.
Huang X; College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling 712100, China.
Hu Z; College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling 712100, China.
Ji S; College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling 712100, China.
Yang M; College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling 712100, China.
Ji H; College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling 712100, China. Electronic address: .; Pokaż więcej
Źródło :: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology [Comp Biochem Physiol B Biochem Mol Biol] 2020 Mar; Vol. 241, pp. 110391. Date of Electronic Publication: 2019 Dec 15.
Typ publikacji :: Journal Article
MeSH Terms :: Synteny*
Adipocytes/*metabolism
Carps/*metabolism
Glycogen Synthase Kinase 3 beta/*metabolism
Hepatocytes/*metabolism
Oleic Acid/*pharmacology
Adipocytes/cytology ; Adipocytes/drug effects ; Amino Acid Sequence ; Animals ; Carps/genetics ; Cells, Cultured ; Cloning, Molecular ; Glycogen Synthase Kinase 3 beta/biosynthesis ; Glycogen Synthase Kinase 3 beta/genetics ; Hepatocytes/cytology ; Hepatocytes/drug effects ; Phylogeny ; Sequence Homology, Amino Acid ; Tissue Distribution
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Wogonin inhibits cell cycle progression by activating the glycogen synthase kinase-3 beta in hepatocellular carcinoma.
Autorzy :: Hong M; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China; Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address: .
Almutairi MM; Department of Pharmacology & Toxicology, University of Kansas, Lawrence, KS, United States.
Li S; Department of Pharmacology & Toxicology, University of Kansas, Lawrence, KS, United States.
Li J; Department of Pharmacology & Toxicology, University of Kansas, Lawrence, KS, United States. Electronic address: .; Pokaż więcej
Źródło :: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2020 Mar; Vol. 68, pp. 153174. Date of Electronic Publication: 2020 Jan 18.
Typ publikacji :: Journal Article
MeSH Terms :: Carcinoma, Hepatocellular/*drug therapy
Cyclin D1/*metabolism
Flavanones/*pharmacology
Glycogen Synthase Kinase 3 beta/*metabolism
Liver Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/pharmacology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Cyclin D1/genetics ; Down-Regulation ; Enzyme Activation/drug effects ; Glycogen Synthase Kinase 3 beta/chemistry ; Glycogen Synthase Kinase 3 beta/genetics ; Hep G2 Cells ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Mice, Inbred BALB C ; Molecular Docking Simulation ; Phosphorylation ; Xenograft Model Antitumor Assays
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: Discovery of Novel Imidazopyridine GSK-3β Inhibitors Supported by Computational Approaches.
Autorzy :: Buonfiglio R; Angelini Pharma S.p.A., Viale Amelia, 70, 00181 Rome, Italy.
Prati F; Angelini Pharma S.p.A., Viale Amelia, 70, 00181 Rome, Italy.
Bischetti M; Angelini Pharma S.p.A., Viale Amelia, 70, 00181 Rome, Italy.
Cavarischia C; Angelini Pharma S.p.A., Viale Amelia, 70, 00181 Rome, Italy.
Furlotti G; Angelini Pharma S.p.A., Viale Amelia, 70, 00181 Rome, Italy.
Ombrato R; Angelini Pharma S.p.A., Viale Amelia, 70, 00181 Rome, Italy.; Pokaż więcej
Źródło :: Molecules (Basel, Switzerland) [Molecules] 2020 May 05; Vol. 25 (9). Date of Electronic Publication: 2020 May 05.
Typ publikacji :: Journal Article
MeSH Terms :: Enzyme Inhibitors/*chemical synthesis
Glycogen Synthase Kinase 3 beta/*antagonists & inhibitors
Imidazoles/*chemical synthesis
Pyridines/*chemistry
Animals ; Binding Sites ; Crystallography, X-Ray ; Dogs ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Glycogen Synthase Kinase 3 beta/chemistry ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Madin Darby Canine Kidney Cells ; Molecular Dynamics Simulation ; Molecular Structure ; Protein Binding ; Quantum Theory ; Structure-Activity Relationship
: Czasopismo naukowe

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