- Tytuł:
-
Vitamin K1 enhances sorafenib-induced growth inhibition and
apoptosis of human malignant glioma cells by blocking the Raf/MEK/ERK pathway. - Autorzy:
- Źródło:
- World journal of surgical oncology [World J Surg Oncol] 2012 Apr 21; Vol. 10, pp. 60. Date of Electronic Publication: 2012 Apr 21.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Apoptosis /*drug effects
Cell Proliferation/*drug effects
Extracellular Signal-Regulated MAP Kinases/*antagonists & inhibitors
Glioma/*pathology
Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors
Niacinamide/*analogs & derivatives
Phenylurea Compounds/*pharmacology
Vitamin K 1/*pharmacology
raf Kinases/*antagonists & inhibitors
Antineoplastic Agents/pharmacology ; Blotting, Western ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Dose-Response Relationship, Drug ; Drug Synergism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Flow Cytometry ; Glioma/drug therapy ; Glioma/metabolism ; Humans ; Immunoenzyme Techniques ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Niacinamide/pharmacology ; Signal Transduction/drug effects ; Sorafenib ; Tumor Cells, Cultured ; Vitamins/pharmacology ; raf Kinases/metabolism
Czasopismo naukowe