Autor: "Goodwin RJA" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Evaluation of Formalin-Fixed and FFPE Tissues for Spatially Resolved Metabolomics and Drug Distribution Studies.
Autorzy:: Dannhorn A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.; Imaging & Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Swales JG; Imaging & Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Hamm G; Imaging & Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Strittmatter N; Imaging & Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Kudo H; Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.
Maglennon G; Oncology Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Goodwin RJA; Imaging & Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Takats Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.; Pokaż więcej
Źródło:: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Oct 23; Vol. 15 (11). Date of Electronic Publication: 2022 Oct 23.
Typ publikacji:: Journal Article

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Skocz do pozycji: 2.

Tytuł:: Mass Spectrometry Detection and Imaging of a Non-Covalent Protein-Drug Complex in Tissue from Orally Dosed Rats.
Autorzy:: Illes-Toth E; School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK.
Hale OJ; School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK.
Hughes JW; School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK.
Strittmatter N; Imaging & Data Analytics Clinical Pharmacology & Safety Sciences Biopharmaceuticals R&D, AstraZeneca Cambridge CB4 0WG UK.
Rose J; Animal Sciences & Technologies Clinical Pharmacology & Safety Sciences, AstraZeneca Babraham Research Campus Babraham Cambridge, CB22 3AT UK.
Clayton B; Animal Sciences & Technologies Clinical Pharmacology & Safety Sciences, AstraZeneca Babraham Research Campus Babraham Cambridge, CB22 3AT UK.
Sargeant R; Imaging & Data Analytics Clinical Pharmacology & Safety Sciences Biopharmaceuticals R&D, AstraZeneca Cambridge CB4 0WG UK.
Jones S; Imaging & Data Analytics Clinical Pharmacology & Safety Sciences Biopharmaceuticals R&D, AstraZeneca Cambridge CB4 0WG UK.
Dannhorn A; Imaging & Data Analytics Clinical Pharmacology & Safety Sciences Biopharmaceuticals R&D, AstraZeneca Cambridge CB4 0WG UK.
Goodwin RJA; Imaging & Data Analytics Clinical Pharmacology & Safety Sciences Biopharmaceuticals R&D, AstraZeneca Cambridge CB4 0WG UK.
Cooper HJ; School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK.; Pokaż więcej
Źródło:: Angewandte Chemie (Weinheim an der Bergstrasse, Germany) [Angew Chem Weinheim Bergstr Ger] 2022 Sep 05; Vol. 134 (36), pp. e202202075. Date of Electronic Publication: 2022 Jul 13.
Typ publikacji:: Journal Article

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Skocz do pozycji: 3.

Tytuł:: Correction: Brüning-Richardson et al. GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models. Cancers 2021, 13 , 5939.
Autorzy:: Brüning-Richardson A; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Shaw GC; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Tams D; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Brend T; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Sanganee H; Discovery Sciences BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 8PA, UK.
Barry ST; Bioscience, Early Oncology, Oncology R&D, AstraZeneca, Cambridge CB2 8PA, UK.
Hamm G; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 8PA, UK.
Goodwin RJA; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 8PA, UK.
Swales JG; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 8PA, UK.
King H; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Steele L; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Morton R; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Widyadari A; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Ward TA; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Esteves F; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Boissinot M; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Mavria G; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Droop A; Leeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds LS9 7TF, UK.
Lawler SE; Pathology & Laboratory Medicine, Brown University Cancer Center, Brown University, Providence, RI 02903, USA.
Short SC; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.; Pokaż więcej
Źródło:: Cancers [Cancers (Basel)] 2022 Aug 04; Vol. 14 (15). Date of Electronic Publication: 2022 Aug 04.
Typ publikacji:: Published Erratum

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Skocz do pozycji: 4.

Tytuł:: GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models.
Autorzy:: Brüning-Richardson A; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Shaw GC; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Tams D; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Brend T; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Sanganee H; Discovery Sciences BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 8PA, UK.
Barry ST; Bioscience, Early Oncology, Oncology R&D, AstraZeneca, Cambridge CB2 8PA, UK.
Hamm G; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 8PA, UK.
Goodwin RJA; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 8PA, UK.
Swales JG; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 8PA, UK.
King H; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Steele L; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Morton R; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Widyadari A; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Ward TA; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Esteves F; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Boissinot M; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Mavria G; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
Droop A; Leeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds LS9 7TF, UK.
Lawler SE; Brown University Cancer Center, Pathology & Laboratory Medicine, Brown University, Providence, RI 02903, USA.
Short SC; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.; Pokaż więcej
Źródło:: Cancers [Cancers (Basel)] 2021 Nov 25; Vol. 13 (23). Date of Electronic Publication: 2021 Nov 25.
Typ publikacji:: Journal Article

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Skocz do pozycji: 5.

Tytuł:: Correction to: Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.
Autorzy:: Davison AS; Department of Clinical Biochemistry and Metabolic Medicine, Liverpool Clinical Laboratories, Royal Liverpool University Hospitals Trust, Liverpool, L7 8XP, UK. .; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK. .
Strittmatter N; Pathology, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Sutherland H; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Hughes AT; Department of Clinical Biochemistry and Metabolic Medicine, Liverpool Clinical Laboratories, Royal Liverpool University Hospitals Trust, Liverpool, L7 8XP, UK.; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Hughes J; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Bou-Gharios G; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Milan AM; Department of Clinical Biochemistry and Metabolic Medicine, Liverpool Clinical Laboratories, Royal Liverpool University Hospitals Trust, Liverpool, L7 8XP, UK.; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Goodwin RJA; Pathology, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Ranganath LR; Department of Clinical Biochemistry and Metabolic Medicine, Liverpool Clinical Laboratories, Royal Liverpool University Hospitals Trust, Liverpool, L7 8XP, UK.; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Gallagher JA; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.; Pokaż więcej
Źródło:: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2019 May 18; Vol. 15 (5), pp. 81. Date of Electronic Publication: 2019 May 18.
Typ publikacji:: Published Erratum

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Skocz do pozycji: 6.

Tytuł:: Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.
Autorzy:: Davison AS; Department of Clinical Biochemistry and Metabolic Medicine, Liverpool Clinical Laboratories, Royal Liverpool University Hospitals Trust, Liverpool, L7 8XP, UK. .; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK. .
Strittmatter N; Pathology, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Sutherland H; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Hughes AT; Department of Clinical Biochemistry and Metabolic Medicine, Liverpool Clinical Laboratories, Royal Liverpool University Hospitals Trust, Liverpool, L7 8XP, UK.; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Hughes J; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Bou-Gharios G; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Milan AM; Department of Clinical Biochemistry and Metabolic Medicine, Liverpool Clinical Laboratories, Royal Liverpool University Hospitals Trust, Liverpool, L7 8XP, UK.; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Goodwin RJA; Pathology, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Ranganath LR; Department of Clinical Biochemistry and Metabolic Medicine, Liverpool Clinical Laboratories, Royal Liverpool University Hospitals Trust, Liverpool, L7 8XP, UK.; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Gallagher JA; Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Health Partners, Liverpool, UK.; Pokaż więcej
Źródło:: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2019 Apr 29; Vol. 15 (5), pp. 68. Date of Electronic Publication: 2019 Apr 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Disease Models, Animal*
Metabolomics*
Brain/*metabolism
Neurotransmitter Agents/*metabolism
Tyrosinemias/*metabolism
Administration, Oral ; Animals ; Brain/diagnostic imaging ; Cyclohexanones/administration & dosage ; Mass Spectrometry ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Nitrobenzoates/administration & dosage ; Optical Imaging ; Tyrosinemias/blood ; Tyrosinemias/chemically induced

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Skocz do pozycji: 7.

Tytuł:: Uncovering the regional localization of inhaled salmeterol retention in the lung.
Autorzy:: Bäckström E; a Drug Metabolism and Pharmacokinetics, Respiratory, Inflammation and Autoimmunity IMED Biotech Unit , AstraZeneca , Gothenburg , Sweden.
Hamm G; b Pathology Sciences, Drug Safety & Metabolism IMED Biotech Unit , AstraZeneca , Cambridge , UK.
Nilsson A; c Biomolecular Mass Spectrometry Imaging, National Resource for MSI, Science for Life Laboratory, Dept. of Pharmaceutical Biosciences , Uppsala University , Uppsala , Sweden.
Fihn BM; a Drug Metabolism and Pharmacokinetics, Respiratory, Inflammation and Autoimmunity IMED Biotech Unit , AstraZeneca , Gothenburg , Sweden.
Strittmatter N; b Pathology Sciences, Drug Safety & Metabolism IMED Biotech Unit , AstraZeneca , Cambridge , UK.
Andrén P; c Biomolecular Mass Spectrometry Imaging, National Resource for MSI, Science for Life Laboratory, Dept. of Pharmaceutical Biosciences , Uppsala University , Uppsala , Sweden.
Goodwin RJA; b Pathology Sciences, Drug Safety & Metabolism IMED Biotech Unit , AstraZeneca , Cambridge , UK.
Fridén M; a Drug Metabolism and Pharmacokinetics, Respiratory, Inflammation and Autoimmunity IMED Biotech Unit , AstraZeneca , Gothenburg , Sweden.; d Translational PKPD Group, Department of Pharmaceutical Biosciences , Uppsala University , Uppsala , Sweden.; Pokaż więcej
Źródło:: Drug delivery [Drug Deliv] 2018 Nov; Vol. 25 (1), pp. 838-845.
Typ publikacji:: Comparative Study; Journal Article
MeSH Terms:: Adrenergic beta-2 Receptor Agonists/*administration & dosage
Bronchi/*metabolism
Bronchodilator Agents/*administration & dosage
Lung/*metabolism
Pulmonary Alveoli/*metabolism
Respiratory Mucosa/*metabolism
Salmeterol Xinafoate/*administration & dosage
Administration, Inhalation ; Adrenergic beta-2 Receptor Agonists/metabolism ; Adrenergic beta-2 Receptor Agonists/pharmacokinetics ; Adrenergic beta-2 Receptor Agonists/pharmacology ; Animals ; Bronchi/cytology ; Bronchi/diagnostic imaging ; Bronchi/drug effects ; Bronchodilator Agents/metabolism ; Bronchodilator Agents/pharmacokinetics ; Bronchodilator Agents/pharmacology ; Cluster Analysis ; Deuterium ; Injections, Intravenous ; Lung/cytology ; Lung/diagnostic imaging ; Lung/drug effects ; Male ; Mass Spectrometry ; Molecular Imaging ; Pharmaceutical Vehicles/chemistry ; Phosphatidylethanolamines/chemistry ; Polyethylene Glycols/chemistry ; Polysorbates/chemistry ; Pulmonary Alveoli/cytology ; Pulmonary Alveoli/diagnostic imaging ; Pulmonary Alveoli/drug effects ; Rats, Wistar ; Respiratory Mucosa/cytology ; Respiratory Mucosa/diagnostic imaging ; Respiratory Mucosa/drug effects ; Respiratory Tract Absorption ; Salmeterol Xinafoate/metabolism ; Salmeterol Xinafoate/pharmacokinetics ; Salmeterol Xinafoate/pharmacology ; Tissue Distribution

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Skocz do pozycji: 8.

Tytuł:: Spatial Quantitation of Drugs in tissues using Liquid Extraction Surface Analysis Mass Spectrometry Imaging.
Autorzy:: Swales JG; Drug Safety &Metabolism, AstraZeneca R&D, Cambridge Science Park, Cambridge, CB4 0WG, UK.; Biomolecular Sciences Research Centre, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK.
Strittmatter N; Drug Safety &Metabolism, AstraZeneca R&D, Cambridge Science Park, Cambridge, CB4 0WG, UK.
Tucker JW; Drug Safety &Metabolism, AstraZeneca R&D, Cambridge Science Park, Cambridge, CB4 0WG, UK.
Clench MR; Biomolecular Sciences Research Centre, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK.
Webborn PJH; Drug Safety &Metabolism, AstraZeneca R&D, Cambridge Science Park, Cambridge, CB4 0WG, UK.
Goodwin RJA; Drug Safety &Metabolism, AstraZeneca R&D, Cambridge Science Park, Cambridge, CB4 0WG, UK.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2016 Nov 24; Vol. 6, pp. 37648. Date of Electronic Publication: 2016 Nov 24.
Typ publikacji:: Journal Article
MeSH Terms:: Imaging, Three-Dimensional*
Organ Specificity*
Chromatography, Liquid/*methods
Pharmaceutical Preparations/*analysis
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods
Animals ; Calibration ; Limit of Detection ; Male ; Rats, Wistar ; Reference Standards ; Spectrometry, Mass, Electrospray Ionization ; Tandem Mass Spectrometry

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