Autor: "Gotthardt M" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa.
Autorzy:: Demine S; ULB-Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Route de Lennik, Brussels 808-CP618, 1070 Brussels, Belgium. .
Balhuizen A; ULB-Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Route de Lennik, Brussels 808-CP618, 1070 Brussels, Belgium. .
Debaille V; Laboratoire G-Time, Université Libre de Bruxelles (ULB), Av. F.D. Roosevelt 50 CP 160/02, 1050 Brussels, Belgium. .
Joosten L; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands. .
Fereau M; Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau 19, Mendeleev Building, B-7000 Mons, Belgium. .
Chilla SNM; Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau 19, Mendeleev Building, B-7000 Mons, Belgium. .
Millard I; ULB-Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Route de Lennik, Brussels 808-CP618, 1070 Brussels, Belgium. .
Scharfmann R; INSERM U1016, Université Paris-Descartes, Institut Cochin, 75014 Paris, France. .
Egrise D; Center for Microscopy and Molecular Imaging (CMMI), Université Libre de Bruxelles (ULB) and University of Mons, 12 Rue des Professeurs Jeener et Brachet, 6041 Charleroi-Gosselies, Belgium. .
Goldman S; Center for Microscopy and Molecular Imaging (CMMI), Université Libre de Bruxelles (ULB) and University of Mons, 12 Rue des Professeurs Jeener et Brachet, 6041 Charleroi-Gosselies, Belgium. .
Marchetti P; Department of Clinical and Experimental Medicine, and University Hospital, University of Pisa, 56100 Pisa, Italy. .
Gotthardt M; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands. martin.gotthardt@radboudumc.nl.
Laurent S; Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau 19, Mendeleev Building, B-7000 Mons, Belgium. .; Center for Microscopy and Molecular Imaging (CMMI), Université Libre de Bruxelles (ULB) and University of Mons, 12 Rue des Professeurs Jeener et Brachet, 6041 Charleroi-Gosselies, Belgium. .
Burtea C; Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau 19, Mendeleev Building, B-7000 Mons, Belgium. .
Eizirik DL; ULB-Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Route de Lennik, Brussels 808-CP618, 1070 Brussels, Belgium. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2018 Aug 21; Vol. 23 (9). Date of Electronic Publication: 2018 Aug 21.
Typ publikacji:: Journal Article
MeSH Terms:: Contrast Media*/chemistry
Heterocyclic Compounds*/chemistry
Magnetic Resonance Imaging*/methods
Molecular Imaging*/methods
Organometallic Compounds*/chemistry
Insulin-Secreting Cells/*metabolism
Sodium-Potassium-Exchanging ATPase/*metabolism
Animals ; Biomarkers ; CHO Cells ; Cricetulus ; Gene Expression ; Heterografts ; Humans ; Insulin-Secreting Cells/transplantation ; Male ; Mice ; Sodium-Potassium-Exchanging ATPase/genetics

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Skocz do pozycji: 2.

Tytuł:: Whole organ and islet of Langerhans dosimetry for calculation of absorbed doses resulting from imaging with radiolabeled exendin.
Autorzy:: van der Kroon I; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Woliner-van der Weg W; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Brom M; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Joosten L; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Frielink C; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Konijnenberg MW; Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, Netherlands.
Visser EP; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Gotthardt M; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2017 Jan 09; Vol. 7, pp. 39800. Date of Electronic Publication: 2017 Jan 09.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Insulin-Secreting Cells/*pathology
Islets of Langerhans/*pathology
Kidney/*metabolism
Radiation Injuries/*diagnosis
Radiometry/*methods
Adult ; Animals ; Cell Count ; Diabetes Mellitus/etiology ; Diabetes Mellitus/genetics ; Disease Models, Animal ; Female ; Gallium Radioisotopes/chemistry ; Gallium Radioisotopes/metabolism ; Humans ; Indium Radioisotopes/chemistry ; Indium Radioisotopes/metabolism ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/radiation effects ; Intercellular Signaling Peptides and Proteins ; Islets of Langerhans/metabolism ; Islets of Langerhans/radiation effects ; Kidney/radiation effects ; Male ; Middle Aged ; Peptides/chemistry ; Peptides/metabolism ; Radiation ; Radiation Dosage ; Rats ; Rats, Mutant Strains ; Young Adult

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Skocz do pozycji: 3.

Tytuł:: Synthesis of GPR40 targeting F-probes towards selective beta cell imaging.
Autorzy:: Bertrand R; Diabetes Division, Research & Translational Medicine, Sanofi GmbH, Frankfurt am Main, Germany.; Department of Nuclear Medicine, Radboud UMC, Nijmegen, The Netherlands.
Hamp I; Diabetes Division, Research & Translational Medicine, Sanofi GmbH, Frankfurt am Main, Germany.
Brönstrup M; Diabetes Division, Research & Translational Medicine, Sanofi GmbH, Frankfurt am Main, Germany.; Helmholtz Centre for Infection Research, Braunschweig, Germany.
Weck R; DSAR/Drug Disposition, Sanofi GmbH, Frankfurt am Main, Germany.
Lukacevic M; Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Polyak A; Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Ross TL; Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Gotthardt M; Department of Nuclear Medicine, Radboud UMC, Nijmegen, The Netherlands.
Plettenburg O; Diabetes Division, Research & Translational Medicine, Sanofi GmbH, Frankfurt am Main, Germany.; Institute of Medicinal Chemistry, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, Neuherberg DE-85764, Germany.; Leibniz Universität Hannover, Schneiderberg 1b, 30167, Hannover, Germany.
Derdau V; DSAR/Drug Disposition, Sanofi GmbH, Frankfurt am Main, Germany.; Pokaż więcej
Źródło:: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2016 Dec; Vol. 59 (14), pp. 604-610. Date of Electronic Publication: 2016 Jun 10.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Fluorine Radioisotopes*
Tritium*
Benzofurans/*chemical synthesis
Benzofurans/*metabolism
Insulin-Secreting Cells/*metabolism
Positron-Emission Tomography/*methods
Receptors, G-Protein-Coupled/*metabolism
Sulfones/*chemical synthesis
Sulfones/*metabolism
Benzofurans/chemistry ; Benzofurans/pharmacokinetics ; Chemistry Techniques, Synthetic ; HEK293 Cells ; Humans ; Sulfones/chemistry ; Sulfones/pharmacokinetics

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Skocz do pozycji: 4.

Tytuł:: Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers.
Autorzy:: Berclaz C; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Pache C; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Bouwens A; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Szlag D; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Grudziadzka 5, PL-87-100 Torun, Poland.
Lopez A; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Joosten L; Radboud University Medical Center, Nijmegen, The Netherlands.
Ekim S; Radboud University Medical Center, Nijmegen, The Netherlands.
Brom M; Radboud University Medical Center, Nijmegen, The Netherlands.
Gotthardt M; Radboud University Medical Center, Nijmegen, The Netherlands.
Grapin-Botton A; Danish Stem Cell Center, University of Copenhagen, Copenhagen, Denmark.
Lasser T; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2015 May 19; Vol. 5, pp. 10385. Date of Electronic Publication: 2015 May 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carbocyanines/*pharmacology
Diabetes Mellitus/*metabolism
Glucagon-Like Peptide-1 Receptor/*analysis
Insulin-Secreting Cells/*cytology
Tomography, Optical Coherence/*methods
Animals ; Cell Line ; Cricetulus ; Female ; Fluorescent Dyes ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/genetics ; Mice ; Mice, Inbred ICR ; Peptides

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