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Tytuł:
Possible psychedelic therapeutic mechanism.
Autorzy:
Hess EM; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Gould TD; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.; Baltimore Veterans Affairs Medical Center, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Feb 17; Vol. 379 (6633), pp. 642-643. Date of Electronic Publication: 2023 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Hallucinogens*/pharmacology
Hallucinogens*/therapeutic use
N,N-Dimethyltryptamine*/pharmacology
N,N-Dimethyltryptamine*/therapeutic use
Receptor, Serotonin, 5-HT2A*/metabolism
Serotonin*/metabolism
Serotonin*/pharmacology
Serotonin 5-HT2 Receptor Agonists*/pharmacology
Serotonin 5-HT2 Receptor Agonists*/therapeutic use
Depression*/drug therapy
Humans ; Animals
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Classical conditioning of antidepressant placebo effects in mice.
Autorzy:
Krimmel SR; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.; Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.
Zanos P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Georgiou P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Colloca L; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Pain Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.; Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA.; Center to Advance Chronic Pain Research, University of Maryland, Baltimore, USA.
Gould TD; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. .; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA. .; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA. .; Veterans Affairs Maryland Health Care System, Baltimore, MD, 21201, USA. .
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2020 Jan; Vol. 237 (1), pp. 93-102. Date of Electronic Publication: 2019 Aug 17.
Typ publikacji:
Journal Article
MeSH Terms:
Antidepressive Agents/*pharmacology
Conditioning, Classical/*drug effects
Depressive Disorder/*drug therapy
Ketamine/*pharmacology
Animals ; Antidepressive Agents/therapeutic use ; Disease Models, Animal ; Female ; Ketamine/therapeutic use ; Locomotion/drug effects ; Male ; Mice ; Placebo Effect ; Swimming
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.
Autorzy:
Zanos P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Highland JN; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Toxicology, University of Maryland School of Medicine, Baltimore, MD, USA.
Liu X; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Troppoli TA; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Georgiou P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Lovett J; Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Morris PJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Stewart BW; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Thompson SM; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Moaddel R; Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Gould TD; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.; Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2019 Jul; Vol. 176 (14), pp. 2573-2592. Date of Electronic Publication: 2019 May 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Anesthetics/*adverse effects
Antidepressive Agents/*adverse effects
Behavior, Animal/*drug effects
Depression/*drug therapy
Ketamine/*adverse effects
Anesthetics/chemistry ; Anesthetics/metabolism ; Animals ; Antidepressive Agents/chemistry ; Antidepressive Agents/metabolism ; Dose-Response Relationship, Drug ; Female ; Infusions, Intraventricular ; Ketamine/analogs & derivatives ; Ketamine/metabolism ; Male ; Mice ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/metabolism ; Stereoisomerism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects.
Autorzy:
Moaddel R; Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes, Bethesda, MD, USA. .
Shardell M; Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes, Bethesda, MD, USA.
Khadeer M; Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes, Bethesda, MD, USA.
Lovett J; Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes, Bethesda, MD, USA.
Kadriu B; Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Ravichandran S; Advanced Biomedical and Computational Sciences, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Leidos Biomedical Research Inc, Fredrick, MD, 21702, USA.
Morris PJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Intramural Research Program, National Institutes of Health, Rockville, MD, USA.
Yuan P; Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Intramural Research Program, National Institutes of Health, Rockville, MD, USA.
Gould TD; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Ferrucci L; Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes, Bethesda, MD, USA.
Zarate CA; Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2018 Oct; Vol. 235 (10), pp. 3017-3030. Date of Electronic Publication: 2018 Aug 16.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Metabolomics*
Depressive Disorder, Major/*drug therapy
Depressive Disorder, Treatment-Resistant/*drug therapy
Ketamine/*therapeutic use
Adult ; Amino Acids, Essential/metabolism ; Antidepressive Agents/pharmacology ; Biogenic Amines/metabolism ; Carnitine/analogs & derivatives ; Carnitine/metabolism ; Cross-Over Studies ; Depressive Disorder, Major/metabolism ; Depressive Disorder, Treatment-Resistant/metabolism ; Double-Blind Method ; Female ; Glycerophospholipids/metabolism ; Humans ; Ketamine/pharmacology ; Lipids ; Male ; Middle Aged ; Sphingolipids/metabolism ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prevalence of neuro-musculoskeletal pain and dysfunction in open-heart surgical patients preoperatively and at 6 and 12 weeks postoperatively: a prospective longitudinal observation study.
Autorzy:
Bellet RN; Physiotherapy Department.
Lamb RL; Physiotherapy Department.
Gould TD; Physiotherapy Department.
Bartlett HJ; Research and Ethics Unit, The Prince Charles Hospital.; Faculty of Science and Technology, Queensland University of Technology, Brisbane, Queensland, Australia.
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Źródło:
Pragmatic and observational research [Pragmat Obs Res] 2017 Oct 10; Vol. 8, pp. 211-222. Date of Electronic Publication: 2017 Oct 10 (Print Publication: 2017).
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Reduced levels of Cacna1c attenuate mesolimbic dopamine system function.
Autorzy:
Terrillion CE; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.
Dao DT; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Cachope R; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Lobo MK; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Puche AC; Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Cheer JF; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Gould TD; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.
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Źródło:
Genes, brain, and behavior [Genes Brain Behav] 2017 Jun; Vol. 16 (5), pp. 495-505. Date of Electronic Publication: 2017 Mar 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Calcium Channels, L-Type/*metabolism
Dopamine Plasma Membrane Transport Proteins/*metabolism
Nucleus Accumbens/*metabolism
Ventral Tegmental Area/*metabolism
Animals ; Calcium Channel Blockers/pharmacology ; Calcium Channels, L-Type/genetics ; Central Nervous System Sensitization ; Dopamine/metabolism ; Dopamine Plasma Membrane Transport Proteins/antagonists & inhibitors ; Dopamine Plasma Membrane Transport Proteins/genetics ; Dopamine Uptake Inhibitors/pharmacology ; Female ; Locomotion ; Male ; Mice ; Mice, Inbred C57BL ; Nimodipine/pharmacology ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/physiology ; Piperazines/pharmacology ; Ventral Tegmental Area/drug effects ; Ventral Tegmental Area/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Irving I. Gottesman (1930-2016): the multifactorial threshold model of complex phenotypes mediated by endophenotype strategies.
Autorzy:
Gould TD; Departments of Psychiatry, Pharmacology, and Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
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Źródło:
Genes, brain, and behavior [Genes Brain Behav] 2016 Nov; Vol. 15 (8), pp. 775-776.
Typ publikacji:
Biography; Historical Article; Journal Article
MeSH Terms:
Behavior*
Epigenomics/*history
Genetics/*history
Schizophrenia/*genetics
Endophenotypes ; History, 20th Century ; History, 21st Century ; Humans
Personal Name as Subject:
Gottesman II
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sex-dependent modulation of age-related cognitive decline by the L-type calcium channel gene Cacna1c (Cav 1.2).
Autorzy:
Zanos P; Department of Psychiatry, University of Maryland School of Medicine, MSTF 936, 685 W. Baltimore Street, Baltimore, MD 21201, USA.
Bhat S; Department of Psychiatry, University of Maryland School of Medicine, MSTF 936, 685 W. Baltimore Street, Baltimore, MD 21201, USA.
Terrillion CE; Department of Psychiatry, University of Maryland School of Medicine, MSTF 936, 685 W. Baltimore Street, Baltimore, MD 21201, USA.
Smith RJ; Department of Psychiatry, University of Maryland School of Medicine, MSTF 936, 685 W. Baltimore Street, Baltimore, MD 21201, USA.
Tonelli LH; Department of Psychiatry, University of Maryland School of Medicine, MSTF 936, 685 W. Baltimore Street, Baltimore, MD 21201, USA.
Gould TD; Department of Psychiatry, University of Maryland School of Medicine, MSTF 936, 685 W. Baltimore Street, Baltimore, MD 21201, USA.; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2015 Oct; Vol. 42 (8), pp. 2499-507. Date of Electronic Publication: 2015 Jun 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Sex Characteristics*
Aging/*physiology
Aging/*psychology
Calcium Channels, L-Type/*metabolism
Cognition Disorders/*physiopathology
Memory Disorders/*physiopathology
Animals ; Avoidance Learning/physiology ; Calcium Channels, L-Type/genetics ; Cognition/physiology ; Emotions/physiology ; Female ; Haploinsufficiency ; Hippocampus/physiopathology ; Male ; Maze Learning/physiology ; Mice, Inbred C57BL ; Mice, Transgenic ; RNA, Messenger/metabolism ; Recognition, Psychology/physiology ; Spatial Memory/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 33

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