Autor: "Goult BT" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Force-dependent focal adhesion assembly and disassembly: A computational study.
Autorzy:: Honasoge KS; Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, the Netherlands.
Karagöz Z; Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, the Netherlands.
Goult BT; School of Biosciences, University of Kent, Canterbury, United Kingdom.
Wolfenson H; Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
LaPointe VLS; Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, the Netherlands.
Carlier A; Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, the Netherlands.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2023 Oct 06; Vol. 19 (10), pp. e1011500. Date of Electronic Publication: 2023 Oct 06 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Focal Adhesions*/metabolism
Actins*/metabolism
Vinculin/metabolism ; Integrins/metabolism ; Extracellular Matrix/metabolism ; Cell Adhesion/physiology ; Talin

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Skocz do pozycji: 2.

Tytuł:: Structural Basis of β2 Integrin Inside-Out Activation.
Autorzy:: Wen L; Department of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, Reno School of Medicine, University of Nevada, Reno, NV 89577, USA.; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Lyu Q; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Immunology Center of Georgia, Augusta University, Augusta, GA 30912, USA.
Ley K; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Immunology Center of Georgia, Augusta University, Augusta, GA 30912, USA.
Goult BT; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Sep 28; Vol. 11 (19). Date of Electronic Publication: 2022 Sep 28.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:: CD18 Antigens*/metabolism
Talin*/metabolism
Integrins/metabolism ; Ligands ; Phosphatidylinositol 3-Kinase ; Phosphatidylinositol 3-Kinases ; Receptors, Chemokine ; Selectins

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Skocz do pozycji: 3.

Tytuł:: Cancer associated talin point mutations disorganise cell adhesion and migration.
Autorzy:: Azizi L; BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Cowell AR; School of Biosciences, University of Kent, Canterbury, CT2 7NJ, Kent, UK.
Mykuliak VV; BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Goult BT; School of Biosciences, University of Kent, Canterbury, CT2 7NJ, Kent, UK. B.T.Goult@kent.ac.uk.
Turkki P; BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. .; Fimlab Laboratories, Tampere, Finland. .
Hytönen VP; BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. .; Fimlab Laboratories, Tampere, Finland. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Jan 11; Vol. 11 (1), pp. 347. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Computational Biology*
Point Mutation*
Cell Adhesion/*genetics
Cell Movement/*genetics
Neoplasms/*genetics
Neoplasms/*pathology
Databases, Genetic ; Humans ; Talin/genetics

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Skocz do pozycji: 4.

Tytuł:: The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.
Autorzy:: Ellis SJ; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada.
Lostchuck E; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada.
Goult BT; School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom.
Bouaouina M; Department of Pharmacology, Yale University, New Haven, Connecticut, United States of America; Carnegie Mellon University Qatar, Education City, Doha, Qatar.
Fairchild MJ; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada.
López-Ceballos P; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada.
Calderwood DA; Department of Pharmacology, Yale University, New Haven, Connecticut, United States of America.
Tanentzapf G; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada.; Pokaż więcej
Źródło:: PLoS genetics [PLoS Genet] 2014 Nov 13; Vol. 10 (11), pp. e1004756. Date of Electronic Publication: 2014 Nov 13 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Adhesion/*genetics
Embryonic Development/*genetics
Integrins/*genetics
Talin/*genetics
Alleles ; Animals ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Drosophila melanogaster/embryology ; Embryo, Nonmammalian ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Fluorescence Recovery After Photobleaching ; Integrins/metabolism ; Point Mutation ; Protein Structure, Tertiary ; Talin/metabolism

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Skocz do pozycji: 5.

Tytuł:: Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation.
Autorzy:: Yao M; 1] Mechanobiology Institute, National University of Singapore, 117411, Singapore [2].
Goult BT; 1] Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester, LE1 9HN, UK [2].
Chen H; 1] Mechanobiology Institute, National University of Singapore, 117411, Singapore [2] Department of Physics, Xiamen University, Xiamen, Fujian, 361005, China.
Cong P; 1] Mechanobiology Institute, National University of Singapore, 117411, Singapore [2] Singapore-MIT Alliance for Research and Technology, National University of Singapore, 117543, Singapore.
Sheetz MP; 1] Mechanobiology Institute, National University of Singapore, 117411, Singapore [2] Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Yan J; 1] Mechanobiology Institute, National University of Singapore, 117411, Singapore [2] Department of Physics, National University of Singapore, 117542, Singapore [3] Centre for Bioimaging Sciences, National University of Singapore, 117546, Singapore.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2014 Apr 09; Vol. 4, pp. 4610. Date of Electronic Publication: 2014 Apr 09.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Mechanical Phenomena*
Protein Folding*
Talin/*metabolism
Vinculin/*metabolism
Binding Sites ; Focal Adhesions/metabolism ; Magnetics ; Molecular Conformation ; Protein Binding ; Protein Conformation ; Protein Structure, Tertiary ; Stress, Mechanical ; Surface Plasmon Resonance

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Skocz do pozycji: 6.

Tytuł:: The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.
Autorzy:: Evans SE; Department of Biochemistry, University of Leicester, Leicester, United Kingdom; Department of Cancer Studies and Molecular Medicine and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom.
Goult BT; Department of Biochemistry, University of Leicester, Leicester, United Kingdom.
Fairall L; Department of Biochemistry, University of Leicester, Leicester, United Kingdom.
Jamieson AG; Department of Chemistry, University of Leicester, Leicester, United Kingdom.
Ko Ferrigno P; Section of Experimental Therapeutics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom.
Ford R; Section of Experimental Therapeutics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom.
Schwabe JW; Department of Biochemistry, University of Leicester, Leicester, United Kingdom.
Wagner SD; Department of Cancer Studies and Molecular Medicine and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Mar 04; Vol. 9 (3), pp. e90889. Date of Electronic Publication: 2014 Mar 04 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anti-Bacterial Agents/*pharmacology
DNA-Binding Proteins/*antagonists & inhibitors
Nuclear Receptor Co-Repressor 2/*metabolism
Repressor Proteins/*antagonists & inhibitors
Rifabutin/*pharmacology
Rifamycins/*pharmacology
Anti-Bacterial Agents/chemistry ; Crystallography, X-Ray ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; HEK293 Cells ; Humans ; Models, Molecular ; Nuclear Receptor Co-Repressor 2/chemistry ; Protein Interaction Maps/drug effects ; Protein Structure, Tertiary ; Proto-Oncogene Proteins c-bcl-6 ; Repressor Proteins/chemistry ; Repressor Proteins/metabolism ; Rifabutin/chemistry ; Rifamycins/chemistry ; Transcription, Genetic/drug effects