Insights into the Mechanism of Action of Antipsychotic Drugs Derived from Animal Models: Standard of Care versus Novel Targets.
Autorzy:
GraceAA; Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA. Uliana DL; Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Beyond Dopamine Receptor Antagonism: New Targets for Schizophrenia Treatment and Prevention.
Autorzy:
Gomes FV; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 01000-000, Brazil. GraceAA; Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Prefrontal cortex modulates firing pattern in the nucleus reuniens of the midline thalamus via distinct corticothalamic pathways.
Autorzy:
Zimmerman EC; Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania. GraceAA; Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Epac-induced ryanodine receptor type 2 activation inhibits sodium currents in atrial and ventricular murine cardiomyocytes.
Autorzy:
Valli H; Physiological Laboratory, University of Cambridge, Cambridge, UK. Ahmad S; Physiological Laboratory, University of Cambridge, Cambridge, UK. Sriharan S; Physiological Laboratory, University of Cambridge, Cambridge, UK. Dean LD; Physiological Laboratory, University of Cambridge, Cambridge, UK. GraceAA; Department of Biochemistry, University of Cambridge, Cambridge, UK. Jeevaratnam K; Physiological Laboratory, University of Cambridge, Cambridge, UK.; Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK.; PU-RCSI School of Medicine, Perdana University, Serdang, Selangor Darul Ehsan, Malaysia. Matthews HR; Physiological Laboratory, University of Cambridge, Cambridge, UK. Huang CL; Physiological Laboratory, University of Cambridge, Cambridge, UK.; Department of Biochemistry, University of Cambridge, Cambridge, UK.
Journal of atrial fibrillation [J Atr Fibrillation] 2018 Feb 28; Vol. 10 (5), pp. 1607. Date of Electronic Publication: 2018 Feb 28 (Print Publication: 2018).
Age-dependent electrocardiographic changes in Pgc-1β deficient murine hearts.
Autorzy:
Ahmad S; Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom. Valli H; Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom. Salvage SC; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom. GraceAA; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom. Jeevaratnam K; Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom.; Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom.; PU-RCSI School of Medicine, Perdana University, Selangor Darul Ehsan, Malaysia. Huang CL; Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom.; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Ion channels, long QT syndrome and arrhythmogenesis in ageing.
Autorzy:
Jeevaratnam K; Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.; School of Medicine, Perdana University-Royal College of Surgeons Ireland, Serdang, Selangor Darul Ehsan, Malaysia. Chadda KR; Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.; Physiological Laboratory, University of Cambridge, Cambridge, UK. Salvage SC; Department of Biochemistry, University of Cambridge, Cambridge, UK. Valli H; Physiological Laboratory, University of Cambridge, Cambridge, UK. Ahmad S; Physiological Laboratory, University of Cambridge, Cambridge, UK. GraceAA; Division of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge, UK. Huang CL; Physiological Laboratory, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge, UK.
The atypical dopamine receptor agonist SKF 83959 enhances hippocampal and prefrontal cortical neuronal network activity in a rat model of cognitive dysfunction.
Autorzy:
Perreault ML; Department of Pharmacology and Toxicology, University of Toronto, Medical Sciences Bldg. Room 4358, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. Fan T; Department of Pharmacology and Toxicology, University of Toronto, Medical Sciences Bldg. Room 4358, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. Banasikowski TJ; Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA, USA. GraceAA; Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA, USA. George SR; Department of Pharmacology and Toxicology, University of Toronto, Medical Sciences Bldg. Room 4358, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.
Arrhythmic effects of Epac-mediated ryanodine receptor activation in Langendorff-perfused murine hearts are associated with reduced conduction velocity.
Autorzy:
Li M; Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom. Hothi SS; Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom. Salvage SC; Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom.; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom. Jeevaratnam K; Faculty of Health and Medical Sciences, VSM Building, University of Surrey, Guildford, United Kingdom. GraceAA; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom. Huang CL; Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom.; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Response to: Depolarization vs. repolarization: what is the mechanism of ventricular arrhythmogenesis underlying sodium channel haploinsufficiency in mouse hearts?
Autorzy:
Jeevaratnam K; Faculty of Health and Medical Science, University of Surrey, Guildford, UK.; Perdana University - Royal College of Surgeons Ireland, Serdang, Selangor Darul Ehsan, Malaysia. Guzadhur L; Division of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge, UK.; Niche Science & Technology, Richmond, UK. Goh YM; Department of Preclinical Sciences, Faculty of Veterinary Medicine, University Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia. GraceAA; Division of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge, UK. Huang CL; Division of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge, UK.; Physiological Laboratory, University of Cambridge, Cambridge, UK.
Sodium channel haploinsufficiency and structural change in ventricular arrhythmogenesis.
Autorzy:
Jeevaratnam K; Faculty of Health and Medical Science, University of Surrey, Guilford, UK.; Perdana University - Royal College of Surgeons Ireland, Serdang, Selangor Darul Ehsan, Malaysia. Guzadhur L; Division of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge, UK.; Niche Science & Technology, Richmond, UK. Goh YM; Department of Preclinical Sciences, Faculty of Veterinary Medicine, University Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia. GraceAA; Division of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge, UK. Huang CL; Division of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge, UK.; Physiological Laboratory, University of Cambridge, Cambridge, UK.
Altered re-excitation thresholds and conduction of extrasystolic action potentials contribute to arrhythmogenicity in murine models of long QT syndrome.
Dopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress.
Autorzy:
GraceAA; Department of Neuroscience, University of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA.
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Źródło:
Neurotoxicity research [Neurotox Res] 2010 Nov; Vol. 18 (3-4), pp. 367-76. Date of Electronic Publication: 2010 Feb 09.
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