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    Tytuł:
    Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
    Autorzy:
    Rappazzo CG; Adimab, LLC, Lebanon, NH 03766, USA.
    Tse LV; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
    Kaku CI; Adimab, LLC, Lebanon, NH 03766, USA.
    Wrapp D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
    Sakharkar M; Adimab, LLC, Lebanon, NH 03766, USA.
    Huang D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Deveau LM; Adimab, LLC, Lebanon, NH 03766, USA.
    Yockachonis TJ; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA.
    Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.
    Battles MB; Adimab, LLC, Lebanon, NH 03766, USA.
    O'Brien CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.
    Brown ME; Adimab, LLC, Lebanon, NH 03766, USA.
    Geoghegan JC; Adimab, LLC, Lebanon, NH 03766, USA.
    Belk J; Adimab, LLC, Lebanon, NH 03766, USA.
    Peng L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Yang L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Hou Y; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
    Scobey TD; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
    Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA.
    Nemazee D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Voss JE; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Gunn BM; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA.
    McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
    Baric RS; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. .; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
    Gralinski LE; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. .
    Walker LM; Adimab, LLC, Lebanon, NH 03766, USA. .; Adagio Therapeutics, Inc., Waltham, MA 02451, USA.
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    Źródło:
    Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531), pp. 823-829. Date of Electronic Publication: 2021 Jan 25.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Antibodies, Monoclonal/*immunology
    Antibodies, Viral/*immunology
    Betacoronavirus/*immunology
    Broadly Neutralizing Antibodies/*immunology
    SARS-CoV-2/*immunology
    Spike Glycoprotein, Coronavirus/*immunology
    Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/metabolism ; Antibodies, Viral/genetics ; Antibodies, Viral/metabolism ; Antibody Affinity ; Binding Sites ; Binding Sites, Antibody ; Broadly Neutralizing Antibodies/genetics ; Broadly Neutralizing Antibodies/metabolism ; COVID-19/prevention & control ; COVID-19/therapy ; Cell Surface Display Techniques ; Directed Molecular Evolution ; Epitopes/immunology ; Humans ; Immunization, Passive ; Immunoglobulin Fc Fragments/immunology ; Mice, Inbred BALB C ; Protein Domains ; Protein Engineering ; Receptors, Coronavirus/metabolism ; Severe acute respiratory syndrome-related coronavirus/immunology ; Severe Acute Respiratory Syndrome/immunology ; Severe Acute Respiratory Syndrome/prevention & control ; Severe Acute Respiratory Syndrome/therapy ; Spike Glycoprotein, Coronavirus/metabolism ; COVID-19 Serotherapy ; Mice
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice.
    Autorzy:
    Graham JB; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, Unites States of America.
    Swarts JL; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, Unites States of America.
    Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
    Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
    Menachery VD; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.; Department of Microbiology and Immunology, University of Texas Medical Center, Galveston, Texas, Unites States of America.
    Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
    Jeng S; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, Unites States of America.; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, Oregon, Unites States of America.
    Miller DR; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
    Mooney MA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, Oregon, Unites States of America.; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon, Unites States of America.
    McWeeney SK; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, Unites States of America.; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, Oregon, Unites States of America.; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon, Unites States of America.
    Ferris MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
    Pardo-Manuel de Villena F; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
    Heise MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
    Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
    Lund JM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, Unites States of America.; Department of Global Health, University of Washington, Seattle, Wasington, Unites States of America.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2021 Jan 29; Vol. 17 (1), pp. e1009287. Date of Electronic Publication: 2021 Jan 29 (Print Publication: 2021).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    COVID-19/*immunology
    COVID-19/*virology
    SARS-CoV-2/*physiology
    T-Lymphocytes/*immunology
    Animals ; COVID-19/genetics ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Phenotype ; Viral Load
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo.
    Autorzy:
    Hou YJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Chiba S; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
    Halfmann P; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
    Ehre C; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Kuroda M; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
    Dinnon KH 3rd; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Nakajima N; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
    Takahashi K; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
    Lee RE; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Mascenik TM; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Graham R; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Edwards CE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Tse LV; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Okuda K; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Markmann AJ; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Bartelt L; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    de Silva A; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Margolis DM; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Boucher RC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Randell SH; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Suzuki T; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
    Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Kawaoka Y; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA. .; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
    Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. .; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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    Źródło:
    Science (New York, N.Y.) [Science] 2020 Dec 18; Vol. 370 (6523), pp. 1464-1468. Date of Electronic Publication: 2020 Nov 12.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    COVID-19/*transmission
    COVID-19/*virology
    SARS-CoV-2/*genetics
    SARS-CoV-2/*pathogenicity
    Amino Acid Substitution ; Angiotensin-Converting Enzyme 2/genetics ; Animals ; Asparagine/genetics ; Cricetinae ; Genetic Fitness/genetics ; Glycine/genetics ; Humans ; Mesocricetus ; Mice ; Mice, Transgenic ; Respiratory Mucosa/virology ; Virulence/genetics ; Virus Replication/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Return of the Coronavirus: 2019-nCoV.
    Autorzy:
    Gralinski LE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA.
    Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
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    Źródło:
    Viruses [Viruses] 2020 Jan 24; Vol. 12 (2). Date of Electronic Publication: 2020 Jan 24.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Betacoronavirus*/genetics
    Betacoronavirus*/isolation & purification
    Coronavirus Infections*/epidemiology
    Coronavirus Infections*/transmission
    Coronavirus Infections*/virology
    Disease Outbreaks*
    Pneumonia, Viral*/epidemiology
    Pneumonia, Viral*/transmission
    Pneumonia, Viral*/virology
    Animals ; COVID-19 ; China ; Communicable Diseases, Emerging ; Disease Reservoirs ; Disease Susceptibility ; Genome, Viral ; Humans ; Nucleocapsid Proteins/chemistry ; Severe acute respiratory syndrome-related coronavirus/chemistry ; Severe acute respiratory syndrome-related coronavirus/genetics ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/virology ; Social Media ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; Zoonoses
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice.
    Autorzy:
    Gralinski LE; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599.
    Menachery VD; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599.
    Morgan AP; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
    Totura AL; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599.
    Beall A; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
    Kocher J; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599.
    Plante J; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599.
    Harrison-Shostak DC; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
    Schäfer A; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599.
    Pardo-Manuel de Villena F; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599.
    Ferris MT; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
    Baric RS; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 .; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599.
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    Źródło:
    G3 (Bethesda, Md.) [G3 (Bethesda)] 2017 Jun 07; Vol. 7 (6), pp. 1653-1663. Date of Electronic Publication: 2017 Jun 07.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Alleles*
    Genetic Predisposition to Disease*
    Genetic Variation*
    Host-Pathogen Interactions/*genetics
    Severe acute respiratory syndrome-related coronavirus/*physiology
    Severe Acute Respiratory Syndrome/*genetics
    Severe Acute Respiratory Syndrome/*virology
    Animals ; Cell Line ; Chromosome Mapping ; Disease Models, Animal ; Female ; Genotype ; Male ; Mice ; Mice, Knockout ; Phenotype ; Quantitative Trait Loci ; Severe Acute Respiratory Syndrome/diagnosis ; Viral Load
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus.
    Autorzy:
    McDermott JE; Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA, 99354, USA.
    Mitchell HD; Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA, 99354, USA. .
    Gralinski LE; Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC, 27599, USA.
    Eisfeld AJ; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, 53715, USA.
    Josset L; Department of Microbiology, University of Washington, Seattle, WA, 98195, USA.
    Bankhead A 3rd; Division of Biostatistics, Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97239, USA.
    Neumann G; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, 53715, USA.
    Tilton SC; Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA, 99354, USA.
    Schäfer A; Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC, 27599, USA.
    Li C; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, 53715, USA.
    Fan S; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, 53715, USA.
    McWeeney S; Division of Biostatistics, Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR, 97239, USA.
    Baric RS; Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
    Katze MG; Department of Microbiology, University of Washington, Seattle, WA, 98195, USA.
    Waters KM; Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA, 99354, USA.
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    Źródło:
    BMC systems biology [BMC Syst Biol] 2016 Sep 23; Vol. 10 (1), pp. 93. Date of Electronic Publication: 2016 Sep 23.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The Mouse Universal Genotyping Array: From Substrains to Subspecies.
    Autorzy:
    Morgan AP; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Fu CP; Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina 27599.
    Kao CY; Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina 27599.
    Welsh CE; Department of Mathematics and Computer Science, Rhodes College, Memphis, Tennessee 38112.
    Didion JP; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Yadgary L; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Hyacinth L; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Ferris MT; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Bell TA; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Miller DR; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Giusti-Rodriguez P; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Nonneman RJ; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Cook KD; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Whitmire JK; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Gralinski LE; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
    Keller M; Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
    Attie AD; Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
    Churchill GA; The Jackson Laboratory, Bar Harbor, Maine 04609.
    Petkov P; The Jackson Laboratory, Bar Harbor, Maine 04609.
    Sullivan PF; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599 Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599.
    Brennan JR; Mutant Mouse Resource and Research Center, University of North Carolina, Chapel Hill, North Carolina 27599.
    McMillan L; Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina 27599.
    Pardo-Manuel de Villena F; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599 .
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    Źródło:
    G3 (Bethesda, Md.) [G3 (Bethesda)] 2015 Dec 18; Vol. 6 (2), pp. 263-79. Date of Electronic Publication: 2015 Dec 18.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Chromosome Mapping*/methods
    Genome*
    Genomics*/methods
    Genotype*
    Alleles ; Animals ; Computational Biology/methods ; Gene Dosage ; Genetics, Population ; Mice ; Mice, Inbred Strains ; Oligonucleotide Array Sequence Analysis ; Phylogeny ; Polymorphism, Single Nucleotide
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.
    Autorzy:
    Gralinski LE; Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Ferris MT; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Aylor DL; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Whitmore AC; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Green R; Department of Microbiology, University of Washington, Seattle, Washington, United States of America.
    Frieman MB; Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Deming D; Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Menachery VD; Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Miller DR; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Buus RJ; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Bell TA; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Churchill GA; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
    Threadgill DW; Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, United States of America.
    Katze MG; Department of Microbiology, University of Washington, Seattle, Washington, United States of America.
    McMillan L; Department of Computer Science, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Valdar W; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Heise MT; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Pardo-Manuel de Villena F; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Baric RS; Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
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    Źródło:
    PLoS genetics [PLoS Genet] 2015 Oct 09; Vol. 11 (10), pp. e1005504. Date of Electronic Publication: 2015 Oct 09 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Host-Pathogen Interactions*
    Inflammation/*genetics
    Severe acute respiratory syndrome-related coronavirus/*genetics
    Severe Acute Respiratory Syndrome/*genetics
    Animals ; Disease Models, Animal ; Disease Susceptibility ; Humans ; Inflammation/pathology ; Inflammation/virology ; Mice ; Phenotype ; Severe acute respiratory syndrome-related coronavirus/pathogenicity ; Severe Acute Respiratory Syndrome/pathology ; Severe Acute Respiratory Syndrome/virology ; Virus Replication/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    New Metrics for Evaluating Viral Respiratory Pathogenesis.
    Autorzy:
    Menachery VD; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
    Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
    Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
    Ferris MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
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    Źródło:
    PloS one [PLoS One] 2015 Jun 26; Vol. 10 (6), pp. e0131451. Date of Electronic Publication: 2015 Jun 26 (Print Publication: 2015).
    Typ publikacji:
    Evaluation Study; Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Influenza A Virus, H1N1 Subtype*
    Plethysmography, Whole Body*
    Severe acute respiratory syndrome-related coronavirus*
    Orthomyxoviridae Infections/*physiopathology
    Severe Acute Respiratory Syndrome/*physiopathology
    Animals ; Chlorocebus aethiops ; Disease Models, Animal ; Dogs ; Lung/pathology ; Lung/virology ; Madin Darby Canine Kidney Cells ; Mice ; Mice, Inbred C57BL ; Predictive Value of Tests ; Vero Cells ; Viral Load ; Virus Replication/physiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice.
    Autorzy:
    Tchitchek N; Department of Microbiology, University of Washington, Seattle, WA 98195 USA.
    Eisfeld AJ
    Tisoncik-Go J
    Josset L
    Gralinski LE
    Bécavin C
    Tilton SC
    Webb-Robertson BJ
    Ferris MT
    Totura AL
    Li C
    Neumann G
    Metz TO
    Smith RD
    Waters KM
    Baric R
    Kawaoka Y
    Katze MG
    Pokaż więcej
    Źródło:
    BMC systems biology [BMC Syst Biol] 2013 Jul 29; Vol. 7, pp. 69. Date of Electronic Publication: 2013 Jul 29.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Mutation*
    Host-Pathogen Interactions/*genetics
    Influenza A Virus, H5N1 Subtype/*genetics
    Influenza A Virus, H5N1 Subtype/*physiology
    Animals ; Female ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/physiology ; Kinetics ; Lung/virology ; Mice ; Mice, Inbred C57BL ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Species Specificity ; Viral Load/genetics ; Viral Proteins/genetics ; Virus Replication/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.
    Autorzy:
    Ferris MT; Carolina Vaccine Institute, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States of America. />Aylor DL
    Bottomly D
    Whitmore AC
    Aicher LD
    Bell TA
    Bradel-Tretheway B
    Bryan JT
    Buus RJ
    Gralinski LE
    Haagmans BL
    McMillan L
    Miller DR
    Rosenzweig E
    Valdar W
    Wang J
    Churchill GA
    Threadgill DW
    McWeeney SK
    Katze MG
    Pardo-Manuel de Villena F
    Baric RS
    Heise MT
    Pokaż więcej
    Źródło:
    PLoS pathogens [PLoS Pathog] 2013 Feb; Vol. 9 (2), pp. e1003196. Date of Electronic Publication: 2013 Feb 28.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Variation*
    Models, Genetic*
    Host-Pathogen Interactions/*genetics
    Influenza, Human/*virology
    Orthomyxoviridae Infections/*virology
    Rodent Diseases/*virology
    Animals ; Crosses, Genetic ; Female ; Humans ; Influenza A virus ; Influenza, Human/genetics ; Influenza, Human/pathology ; Lung/pathology ; Mice ; Mice, Inbred Strains ; Orthomyxoviridae Infections/genetics ; Orthomyxoviridae Infections/pathology ; Phenotype ; Reassortant Viruses/genetics ; Reassortant Viruses/pathogenicity ; Recombination, Genetic ; Rodent Diseases/genetics ; Rodent Diseases/pathology ; Species Specificity ; Virus Replication
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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