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Tytuł:
Ionizing radiation induces ferroptosis in granulocyte-macrophage hematopoietic progenitor cells of murine bone marrow.
Autorzy:
Zhang X; Department of Nuclear Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, PR China.; Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, PR China.; Key Laboratory of Nuclear Technology Application and Radiation Protection in Astronautics (Nanjing University of Aeronautics and Astronautics), Ministry of Industry and Information Technology, Nanjing, PR China.; Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, PR China.
Xing X; Department of Nuclear Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, PR China.
Liu H; Department of Nuclear Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, PR China.
Feng J; Department of Nuclear Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, PR China.; Key Laboratory of Nuclear Technology Application and Radiation Protection in Astronautics (Nanjing University of Aeronautics and Astronautics), Ministry of Industry and Information Technology, Nanjing, PR China.
Tian M; Department of Nuclear Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, PR China.
Chang S; Department of Nuclear Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, PR China.; Key Laboratory of Nuclear Technology Application and Radiation Protection in Astronautics (Nanjing University of Aeronautics and Astronautics), Ministry of Industry and Information Technology, Nanjing, PR China.
Liu P; Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, PR China.
Zhang H; Department of Nuclear Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, PR China.; Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, PR China.
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Źródło:
International journal of radiation biology [Int J Radiat Biol] 2020 May; Vol. 96 (5), pp. 584-595. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ferroptosis/*radiation effects
Granulocyte-Macrophage Progenitor Cells/*radiation effects
Animals ; Cyclohexylamines/pharmacology ; Gamma Rays ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Granulocyte-Macrophage Progenitor Cells/pathology ; Iron/metabolism ; Leukocyte Count ; Male ; Mice ; Mice, Inbred ICR ; Phenylenediamines/pharmacology ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Calcium Pyrophosphate Dihydrate Crystals Increase the Granulocyte/Monocyte Progenitor (GMP) and Enhance Granulocyte and Monocyte Differentiation In Vivo.
Autorzy:
Onai N; Department of Immunology, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Ogasawara C; Department of Immunology, Kanazawa Medical University, Ishikawa 920-0293, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 29; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 29.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation*
Calcium Pyrophosphate/*chemistry
Calcium Pyrophosphate/*metabolism
Granulocyte-Macrophage Progenitor Cells/*cytology
Granulocyte-Macrophage Progenitor Cells/*metabolism
Granulocytes/*metabolism
Monocytes/*metabolism
Animals ; Biomarkers ; Bone Marrow ; Cytokines/metabolism ; Granulocytes/cytology ; Immunophenotyping ; Inflammation Mediators/metabolism ; Leukocyte Count ; Liquid Crystals ; Mice ; Monocytes/cytology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Deletion of Stat3 enhances myeloid cell expansion and increases the severity of myeloproliferative neoplasms in Jak2V617F knock-in mice.
Autorzy:
Yan D; Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Jobe F; Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Hutchison RE; Department of Pathology, SUNY Upstate Medical University, Syracuse, NY, USA.
Mohi G; Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
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Źródło:
Leukemia [Leukemia] 2015 Oct; Vol. 29 (10), pp. 2050-61. Date of Electronic Publication: 2015 May 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Granulocyte-Macrophage Progenitor Cells/*pathology
Hematopoietic Stem Cells/*pathology
Janus Kinase 2/*physiology
Myeloid Cells/*pathology
Myeloproliferative Disorders/*pathology
STAT3 Transcription Factor/*physiology
Animals ; Apoptosis ; Bone Marrow Transplantation ; Cell Proliferation ; Female ; Flow Cytometry ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Hematopoietic Stem Cells/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloid Cells/metabolism ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/mortality ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Severity of Illness Index ; Survival Rate ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NFκB-Dependent Proliferation and Proinflammatory Activation of Macrophages.
Autorzy:
Wan X; Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77550, USA.
Chowdhury IH; Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77550, USA.
Jie Z; Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77550, USA.
Choudhuri S; Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77550, USA.
Garg NJ; Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77550, USA.; Institute for Human Infections and Immunity, UTMB, Galveston, TX 77550, USA.
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Źródło:
Cells [Cells] 2019 Dec 28; Vol. 9 (1). Date of Electronic Publication: 2019 Dec 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Chagas Disease/*complications
Chagas Disease/*metabolism
Inflammation/*complications
Inflammation/*metabolism
Macrophages/*metabolism
Monocytes/*metabolism
Animals ; Biomarkers ; Chagas Disease/mortality ; Chagas Disease/parasitology ; Chronic Disease ; Cytokines/biosynthesis ; Disease Models, Animal ; Disease Susceptibility ; Female ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Immunophenotyping ; Inflammation/parasitology ; Inflammation Mediators/metabolism ; Macrophage Activation/immunology ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/pathology ; Mice ; Monocytes/drug effects ; Monocytes/immunology ; Monocytes/pathology ; Protein Serine-Threonine Kinases/metabolism ; Reactive Oxygen Species/metabolism ; Sirtuin 1/metabolism ; NF-kappaB-Inducing Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ.
Autorzy:
Hsu LC; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. />Enzler T
Seita J
Timmer AM
Lee CY
Lai TY
Yu GY
Lai LC
Temkin V
Sinzig U
Aung T
Nizet V
Weissman IL
Karin M
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Źródło:
Nature immunology [Nat Immunol] 2011 Feb; Vol. 12 (2), pp. 144-50. Date of Electronic Publication: 2010 Dec 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Bacterial Infections/*immunology
Granulocyte-Macrophage Progenitor Cells/*metabolism
I-kappa B Kinase/*metabolism
Interleukin-1beta/*metabolism
Neutrophils/*metabolism
Animals ; Cell Count ; Cell Growth Processes/genetics ; Cell Survival/genetics ; Cells, Cultured ; Disease Susceptibility ; Granulocyte-Macrophage Progenitor Cells/immunology ; Granulocyte-Macrophage Progenitor Cells/pathology ; I-kappa B Kinase/genetics ; I-kappa B Kinase/immunology ; Immunity, Innate/genetics ; Interleukin-1beta/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microarray Analysis ; Neutrophils/immunology ; Neutrophils/pathology ; Receptors, Interleukin-1 Type I/genetics ; Up-Regulation/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Spanish black radish (Raphanus sativus L. Var. niger) diet enhances clearance of DMBA and diminishes toxic effects on bone marrow progenitor cells.
Autorzy:
N'jai AU; Department of Pathobiological Sciences and Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin, USA.
Kemp MQ
Metzger BT
Hanlon PR
Robbins M
Czuyprynski C
Barnes DM
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Źródło:
Nutrition and cancer [Nutr Cancer] 2012; Vol. 64 (7), pp. 1038-48.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diet*
Raphanus*
9,10-Dimethyl-1,2-benzanthracene/*pharmacokinetics
Bone Marrow Cells/*drug effects
Granulocyte-Macrophage Progenitor Cells/*drug effects
9,10-Dimethyl-1,2-benzanthracene/toxicity ; Animals ; Bone Marrow Cells/metabolism ; Dose-Response Relationship, Drug ; Female ; Glucosinolates/pharmacology ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Plant Extracts/pharmacology ; Real-Time Polymerase Chain Reaction ; Spain
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reduction of CFU-GM and circulating hematopoietic progenitors in a subgroup of children with chronic neutropenia associated with severe infections and delayed recovery.
Autorzy:
Timeus F; Pediatric Onco-Hematology, Regina Margherita Children Hospital, Turin, Italy.
Crescenzio N; Pediatric Hematology, Regina Margherita Children Hospital, University of Turin, Turin, Italy.
Foglia L; Pediatric Hematology, Regina Margherita Children Hospital, University of Turin, Turin, Italy.
Doria A; Pediatric Hematology, Regina Margherita Children Hospital, University of Turin, Turin, Italy.
Stillitano MG; Pediatric Hematology, Regina Margherita Children Hospital, University of Turin, Turin, Italy.
Garelli E; Pediatric Hematology, Regina Margherita Children Hospital, University of Turin, Turin, Italy.
Mazzone R; Biochemistry Laboratory, Regina Margherita Children Hospital, Turin, Italy.
Vivalda L; Pediatric Hematology, Regina Margherita Children Hospital, University of Turin, Turin, Italy.
Vallero S; Pediatric Onco-Hematology, Regina Margherita Children Hospital, Turin, Italy.
Ramenghi U; Pediatric Hematology, Regina Margherita Children Hospital, University of Turin, Turin, Italy.
Saracco P; Pediatric Hematology, Regina Margherita Children Hospital, University of Turin, Turin, Italy.
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Źródło:
PloS one [PLoS One] 2019 Mar 14; Vol. 14 (3), pp. e0213782. Date of Electronic Publication: 2019 Mar 14 (Print Publication: 2019).
Typ publikacji:
Journal Article
MeSH Terms:
Recovery of Function*
Granulocyte-Macrophage Progenitor Cells/*pathology
Hematopoietic Stem Cells/*pathology
Infections/*complications
Neutropenia/*pathology
Adolescent ; Antigens, CD34/analysis ; Cells, Cultured ; Child ; Child, Preschool ; Colony-Forming Units Assay ; Female ; Humans ; Infant ; Male ; Neutropenia/etiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Panel reactive antibody in thalassemic serum inhibits proliferation and differentiation of cord blood CD34+ cells in vitro.
Autorzy:
Fang JP; Department of Pediatrics, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. />Xu LH
Yang XG
Wu YF
Weng WJ
Xu HG
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Źródło:
Pediatric hematology and oncology [Pediatr Hematol Oncol] 2009 Jul-Aug; Vol. 26 (5), pp. 338-44.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies/*immunology
Antigens, CD34/*immunology
Erythroid Precursor Cells/*immunology
Fetal Blood/*immunology
Granulocyte-Macrophage Progenitor Cells/*immunology
Myeloid Progenitor Cells/*immunology
beta-Thalassemia/*immunology
Antibodies/blood ; Apoptosis/immunology ; Cell Differentiation/immunology ; Cells, Cultured ; Child ; Erythroid Precursor Cells/cytology ; Fetal Blood/cytology ; Granulocyte-Macrophage Progenitor Cells/cytology ; Humans ; Myeloid Progenitor Cells/cytology ; beta-Thalassemia/blood
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Transcriptional regulation of mast cell and basophil lineage commitment.
Autorzy:
Huang H; Department of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA. .; Department of Immunology and Microbiology, University of Colorado School of Medicine, Denver, CO, 80206, USA. .; Department of Biomedical Research, National Jewish Health and Department of Immunology and Microbiology, University of Colorado School of Medicine, 1400 Jackson Street, Denver, CO, 80206, USA. .
Li Y; Department of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA.
Liu B; Department of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA.; Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China.
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Źródło:
Seminars in immunopathology [Semin Immunopathol] 2016 Sep; Vol. 38 (5), pp. 539-48. Date of Electronic Publication: 2016 Apr 28.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
Gene Expression Regulation*
Transcription, Genetic*
Basophils/*cytology
Basophils/*metabolism
Cell Differentiation/*genetics
Mast Cells/*cytology
Mast Cells/*metabolism
Animals ; Basophils/immunology ; CCAAT-Enhancer-Binding Proteins/metabolism ; Cell Lineage/genetics ; Granulocyte-Macrophage Progenitor Cells/cytology ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Hematopoiesis/genetics ; Humans ; Mast Cells/immunology ; Mice ; Microphthalmia-Associated Transcription Factor/metabolism ; Organ Specificity/genetics ; Protein Binding ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Quantifying intrinsic and extrinsic control of single-cell fates in cancer and stem/progenitor cell pedigrees with competing risks analysis.
Autorzy:
Cornwell JA; Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia.; Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.; Australian Research Council Special Research Initiative in Stem Cell Science - Stem Cells, Australia.
Hallett RM; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
der Mauer SA; Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
Motazedian A; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.; McMaster Stem Cell and Cancer Research Institute, Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada.; Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria 3052, Australia.
Schroeder T; Cell Systems Dynamics, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Draper JS; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.; McMaster Stem Cell and Cancer Research Institute, Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Harvey RP; Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.; Australian Research Council Special Research Initiative in Stem Cell Science - Stem Cells, Australia.; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Nordon RE; Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia.; Australian Research Council Special Research Initiative in Stem Cell Science - Stem Cells, Australia.
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Źródło:
Scientific reports [Sci Rep] 2016 Jun 01; Vol. 6, pp. 27100. Date of Electronic Publication: 2016 Jun 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Breast Neoplasms/*genetics
Cell Lineage/*genetics
Cell Tracking/*statistics & numerical data
Single-Cell Analysis/*statistics & numerical data
Tumor Suppressor Protein p53/*genetics
Animals ; Antibiotics, Antineoplastic/pharmacology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Death/drug effects ; Cell Differentiation ; Cell Division/drug effects ; Cell Line, Tumor ; Cell Tracking/methods ; Cytokines/pharmacology ; Doxorubicin/pharmacology ; Female ; Genotype ; Granulocyte-Macrophage Progenitor Cells/cytology ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Humans ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Mice ; Single-Cell Analysis/methods ; Time-Lapse Imaging
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
In vitro and in vivo effects of JAK2 inhibition in chronic myelomonocytic leukemia.
Autorzy:
Geissler K; 5th Medical Department with Hematology, Oncology and Palliative Medicine, Hospital Hietzing, Vienna, Austria.
Jäger E; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Barna A; Blood Transfusion Service for Upper Austria, Austrian Red Cross, Linz, Austria.
Sliwa T; 3rd Medical Department, Hanusch Hospital, Vienna, Austria.
Knöbl P; Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Schwarzinger I; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Gisslinger H; Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Valent P; Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
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Źródło:
European journal of haematology [Eur J Haematol] 2016 Dec; Vol. 97 (6), pp. 562-567. Date of Electronic Publication: 2016 Jun 15.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Janus Kinase 2/*antagonists & inhibitors
Leukemia, Myelomonocytic, Chronic/*metabolism
Protein Kinase Inhibitors/*pharmacology
Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; Cell Proliferation/drug effects ; Colony-Forming Units Assay ; Dose-Response Relationship, Drug ; Female ; Granulocyte-Macrophage Progenitor Cells/drug effects ; Humans ; Janus Kinase 2/genetics ; Leukemia, Myelomonocytic, Chronic/diagnosis ; Leukemia, Myelomonocytic, Chronic/drug therapy ; Male ; Middle Aged ; Mutation ; Nitriles ; Protein Kinase Inhibitors/therapeutic use ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Pyrimidines ; Tomography, X-Ray Computed
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of early myeloid progenitors as immunosuppressive cells.
Autorzy:
Pu S; School of Life Sciences, Guangxi Normal University, Guilin 541004, China.; Guangxi Universities Key Laboratory of Stem cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin 541004, China.
Qin B; School of Life Sciences, Guangxi Normal University, Guilin 541004, China.
He H; State Key Laboratory of Molecular Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100021, China.
Zhan J; School of Life Sciences, Guangxi Normal University, Guilin 541004, China.
Wu Q; School of Life Sciences, Guangxi Normal University, Guilin 541004, China.; Guangxi Universities Key Laboratory of Stem cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin 541004, China.; Research Center for Biomedical Sciences, Guangxi Normal University, Guilin 541004, China.
Zhang X; School of Life Sciences, Guangxi Normal University, Guilin 541004, China.; Research Center for Biomedical Sciences, Guangxi Normal University, Guilin 541004, China.
Yang L; School of Life Sciences, Guangxi Normal University, Guilin 541004, China.; Guangxi Universities Key Laboratory of Stem cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin 541004, China.; Research Center for Biomedical Sciences, Guangxi Normal University, Guilin 541004, China.
Qu C; State Key Laboratory of Molecular Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100021, China.
Zhou Z; School of Life Sciences, Guangxi Normal University, Guilin 541004, China.; Guangxi Universities Key Laboratory of Stem cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin 541004, China.; Research Center for Biomedical Sciences, Guangxi Normal University, Guilin 541004, China.
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Źródło:
Scientific reports [Sci Rep] 2016 Mar 16; Vol. 6, pp. 23115. Date of Electronic Publication: 2016 Mar 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Lewis Lung/*immunology
Hematopoietic Stem Cells/*immunology
Myeloid Progenitor Cells/*immunology
T-Lymphocytes/*immunology
Animals ; Carcinoma, Lewis Lung/genetics ; Carcinoma, Lewis Lung/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Cells, Cultured ; Coculture Techniques ; Disease Progression ; Female ; Flow Cytometry ; Gene Expression Regulation, Neoplastic ; Granulocyte-Macrophage Progenitor Cells/immunology ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Hematopoietic Stem Cells/metabolism ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Myeloid Progenitor Cells/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; T-Lymphocytes/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Interleukin-10 inhibits autonomous myelopoiesis in patients with myelofibrosis.
Autorzy:
Geissler K; 5th Department of Internal Medicine - Oncology/Hematology, Hospital Hietzing, Vienna, Austria.; Ludwig Boltzmann Institute for Clinical Oncology, Vienna, Austria.
Jäger E; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Öhler L; Department of Internal Medicine I, St-Josef-Krankenhaus, Vienna, Austria.
Gisslinger H; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Jäger U; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Lechner K; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
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Źródło:
European journal of haematology [Eur J Haematol] 2015 Sep; Vol. 95 (3), pp. 239-43. Date of Electronic Publication: 2015 Jan 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Myelopoiesis*
Interleukin-10/*metabolism
Primary Myelofibrosis/*metabolism
Aged ; Aged, 80 and over ; Colony-Forming Units Assay ; Dose-Response Relationship, Drug ; Female ; Granulocyte-Macrophage Progenitor Cells/drug effects ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Humans ; Interleukin-10/pharmacology ; Male ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular profiling of myeloid progenitor cells in multi-mutated advanced systemic mastocytosis identifies KIT D816V as a distinct and late event.
Autorzy:
Jawhar M; Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany.
Schwaab J; Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany.
Schnittger S; Munich Leukemia Laboratory, Munich, Germany.
Sotlar K; Department of Pathology, Ludwig-Maximilians-University, Munich, Germany.
Horny HP; Department of Pathology, Ludwig-Maximilians-University, Munich, Germany.
Metzgeroth G; Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany.
Müller N; Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany.
Schneider S; Department of Clinical Chemistry, University Hospital Mannheim, Mannheim, Germany.
Naumann N; Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany.
Walz C; Department of Pathology, Ludwig-Maximilians-University, Munich, Germany.
Haferlach T; Munich Leukemia Laboratory, Munich, Germany.
Valent P; Division of Hematology and Ludwig Boltzmann Cluster Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Hofmann WK; Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany.
Cross NC; 1] Wessex Regional Genetics Laboratory, Salisbury, UK [2] Faculty of Medicine, University of Southampton, Southampton, UK.
Fabarius A; Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany.
Reiter A; Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany.
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Źródło:
Leukemia [Leukemia] 2015 May; Vol. 29 (5), pp. 1115-22. Date of Electronic Publication: 2015 Jan 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Mutational Analysis*
Mastocytosis, Systemic/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Stem Cells/*cytology
Aged ; Cell Lineage ; Cell Separation ; Cytogenetics ; DNA-Binding Proteins/genetics ; Dioxygenases ; Female ; Flow Cytometry ; Genotype ; Granulocyte-Macrophage Progenitor Cells/cytology ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Mast Cells/cytology ; Middle Aged ; Mutation ; Nuclear Proteins/genetics ; Phenotype ; Prognosis ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Repressor Proteins/genetics ; Ribonucleoproteins/genetics ; Serine-Arginine Splicing Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Quantification of nucleated cells, CD34-positive cells and CFU-GM colonies in single bone marrow samples and bone marrow harvests derived from healthy children.
Autorzy:
Schündeln MM; Department of Pediatric Hematology and Oncology, University Hospital, Essen, Germany.
Walde G
Basu O
Havers W
Kremens B
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Źródło:
Pediatric hematology and oncology [Pediatr Hematol Oncol] 2014 May; Vol. 31 (4), pp. 340-8. Date of Electronic Publication: 2014 Feb 05.
Typ publikacji:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, CD34*
Bone Marrow*
Aging/*physiology
Granulocyte-Macrophage Progenitor Cells/*cytology
Hematopoiesis/*physiology
Adolescent ; Adult ; Cell Count ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Retrospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Auto-SCT induces a phenotypic shift from CMP to GMP progenitors, reduces clonogenic potential and enhances in vitro and in vivo cycling activity defined by (18)F-FLT PET scanning.
Autorzy:
Woolthuis C; Department of Hematology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Agool A
Olthof S
Slart RH
Huls G
Smid WM
Schuringa JJ
Vellenga E
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Źródło:
Bone marrow transplantation [Bone Marrow Transplant] 2011 Jan; Vol. 46 (1), pp. 110-5. Date of Electronic Publication: 2010 Apr 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Cycle*
Hematopoietic Stem Cell Transplantation*
Phenotype*
Molecular Imaging/*methods
Myeloid Progenitor Cells/*metabolism
Adult ; Antigens, CD34/metabolism ; Bone Marrow/metabolism ; Colony-Forming Units Assay ; Dideoxynucleosides/pharmacokinetics ; Follow-Up Studies ; Granulocyte-Macrophage Progenitor Cells/cytology ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Humans ; Lymphoma/therapy ; Middle Aged ; Myeloid Progenitor Cells/cytology ; Positron-Emission Tomography ; Radiopharmaceuticals/pharmacokinetics ; Tissue Distribution ; Transplantation, Autologous ; Whole Body Imaging
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.
Autorzy:
Wang Y; Division of Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Krivtsov AV
Sinha AU
North TE
Goessling W
Feng Z
Zon LI
Armstrong SA
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Źródło:
Science (New York, N.Y.) [Science] 2010 Mar 26; Vol. 327 (5973), pp. 1650-3.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
Hematopoietic Stem Cells/*metabolism
Leukemia, Myeloid, Acute/*metabolism
Leukemia, Myeloid, Acute/*pathology
Neoplastic Stem Cells/*pathology
Wnt Proteins/*metabolism
beta Catenin/*metabolism
Animals ; Cell Proliferation ; Cell Transformation, Neoplastic ; Genes, Homeobox ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Granulocyte-Macrophage Progenitor Cells/pathology ; Hematopoietic Stem Cells/pathology ; Homeodomain Proteins/genetics ; Indomethacin/pharmacology ; Mice ; Mice, Inbred C57BL ; Myeloid Ecotropic Viral Integration Site 1 Protein ; Neoplasm Proteins/genetics ; Transduction, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Chlorella vulgaris modulates immunomyelopoietic activity and enhances the resistance of tumor-bearing mice.
Autorzy:
Ramos AL; Departamento de Farmacologia/Hemocentro, Faculdade de Ciências Médicas, FCM, Universidade Estadual de Campinas, UNICAMP, Campinas, São Paulo, Brazil.
Torello CO
Queiroz ML
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Źródło:
Nutrition and cancer [Nutr Cancer] 2010; Vol. 62 (8), pp. 1170-80.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chlorella vulgaris*
Myelopoiesis*
Antineoplastic Agents, Phytogenic/*therapeutic use
Carcinoma, Ehrlich Tumor/*drug therapy
Carcinoma, Ehrlich Tumor/*immunology
Immunologic Factors/*therapeutic use
Animals ; Bone Marrow Cells/immunology ; Bone Marrow Cells/metabolism ; Carcinoma, Ehrlich Tumor/metabolism ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Colony-Stimulating Factors/blood ; Colony-Stimulating Factors/metabolism ; Cytokines/metabolism ; Dietary Supplements ; Granulocyte-Macrophage Progenitor Cells/cytology ; Granulocyte-Macrophage Progenitor Cells/immunology ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Hematopoietic Stem Cells/immunology ; Hematopoietic Stem Cells/metabolism ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Phytotherapy ; Specific Pathogen-Free Organisms ; Spleen/cytology ; Spleen/immunology ; Spleen/metabolism ; Stromal Cells/immunology ; Stromal Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hematopoietic cytokines can instruct lineage choice.
Autorzy:
Rieger MA; Institute of Stem Cell Research, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg-Munich, Germany.
Hoppe PS
Smejkal BM
Eitelhuber AC
Schroeder T
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Źródło:
Science (New York, N.Y.) [Science] 2009 Jul 10; Vol. 325 (5937), pp. 217-8.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Lineage*
Granulocyte Colony-Stimulating Factor/*physiology
Granulocyte-Macrophage Progenitor Cells/*cytology
Granulocyte-Macrophage Progenitor Cells/*physiology
Macrophage Colony-Stimulating Factor/*physiology
Animals ; Cell Death ; Cells, Cultured ; Colony-Forming Units Assay ; Mice ; Monocytes/cytology ; Myelopoiesis ; Neutrophils/cytology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.
Autorzy:
Reckzeh K; Department of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden.
Bereshchenko O
Mead A
Rehn M
Kharazi S
Jacobsen SE
Nerlov C
Cammenga J
Pokaż więcej
Źródło:
Leukemia [Leukemia] 2012 Jul; Vol. 26 (7), pp. 1527-36. Date of Electronic Publication: 2012 Feb 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Models, Animal*
CCAAT-Enhancer-Binding Proteins/*physiology
Cell Transformation, Neoplastic/*pathology
Leukemia, Myeloid, Acute/*genetics
Leukemia, Myeloid, Acute/*pathology
Mutation/*genetics
fms-Like Tyrosine Kinase 3/*physiology
Animals ; Cell Differentiation ; Cell Proliferation ; Female ; Flow Cytometry ; Granulocyte-Macrophage Progenitor Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Tandem Repeat Sequences/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Preservation of differentiation and clonogenic potential of human hematopoietic stem and progenitor cells during lyophilization and ambient storage.
Autorzy:
Buchanan SS; Center for Pharmaceutical Biotechnology and Department of Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, United States of America. />Pyatt DW
Carpenter JF
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Źródło:
PloS one [PLoS One] 2010 Sep 01; Vol. 5 (9). Date of Electronic Publication: 2010 Sep 01.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Cell Differentiation*
Freeze Drying/*methods
Hematopoietic Stem Cells/*cytology
Cell Proliferation ; Fetal Blood/cytology ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Hematopoietic Stem Cells/metabolism ; Humans ; Myeloid Progenitor Cells/metabolism ; Temperature
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Bone marrow dysfunction in chronic heart failure patients.
Autorzy:
Westenbrink BD; Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands. />Voors AA
de Boer RA
Schuringa JJ
Klinkenberg T
van der Harst P
Vellenga E
van Veldhuisen DJ
van Gilst WH
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Źródło:
European journal of heart failure [Eur J Heart Fail] 2010 Jul; Vol. 12 (7), pp. 676-84. Date of Electronic Publication: 2010 Apr 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bone Marrow/*physiopathology
Heart Failure/*physiopathology
Hematopoietic Stem Cells/*physiology
Aged ; Apoptosis/physiology ; Cell Count ; Cell Differentiation/physiology ; Erythroid Precursor Cells/cytology ; Female ; Flow Cytometry ; Granulocyte-Macrophage Progenitor Cells/cytology ; Hematopoiesis/physiology ; Humans ; Male ; Middle Aged ; Receptors, Erythropoietin/analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Development of a reliable low-cost controlled cooling rate instrument for the cryopreservation of hematopoietic stem cells.
Autorzy:
Shu Z; Department of Mechanical Engineering, University of Washington, Seattle, Washington 98195 , USA.
Kang X
Chen H
Zhou X
Purtteman J
Yadock D
Heimfeld S
Gao D
Pokaż więcej
Źródło:
Cytotherapy [Cytotherapy] 2010 Apr; Vol. 12 (2), pp. 161-9.
Typ publikacji:
Journal Article
MeSH Terms:
Cold Temperature*
Cryopreservation/*economics
Cryopreservation/*instrumentation
Hematopoietic Stem Cells/*cytology
Antigens, CD34/metabolism ; Cell Survival ; Colony-Forming Units Assay ; Cryopreservation/methods ; Erythroid Precursor Cells/cytology ; Granulocyte-Macrophage Progenitor Cells/cytology ; Humans ; Models, Biological
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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