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Wyszukujesz frazę ""Granzymes"" wg kryterium: Temat


Tytuł :
New Method for the Expansion of Highly Purified Human Regulatory Granzyme B-Expressing B Cells.
Autorzy :
Chesneau M; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.; Labex IGO, Nantes, France.
Le Mai H; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.; Labex IGO, Nantes, France.
Brouard S; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France. .; Labex IGO, Nantes, France. .; Centre d'Investigation Clinique en Biothérapie, Centre de ressources biologiques (CRB), Nantes, France. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 203-216.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes, Regulatory/*immunology
Cell Culture Techniques/*methods
Granzymes/*isolation & purification
Apoptosis/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; B-Lymphocytes, Regulatory/metabolism ; Cell Proliferation ; Granzymes/immunology ; Granzymes/metabolism ; Humans ; Lymphocyte Activation ; T-Lymphocytes, Cytotoxic/immunology
Czasopismo naukowe
Tytuł :
Granzyme B Induces IRF-3 Phosphorylation through a Perforin-Independent Proteolysis-Dependent Signaling Cascade without Inducing Cell Death.
Autorzy :
Gapud EJ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Trejo-Zambrano MI; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Gomez-Banuelos E; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Tiniakou E; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Antiochos B; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Granville DJ; International Collaboration on Repair Discoveries Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
Andrade F; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Casciola-Rosen L; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Rosen A; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224; .; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21224; and.; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Jan 15; Vol. 206 (2), pp. 335-344. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Fibroblasts/*physiology
Granzymes/*metabolism
Interferon Regulatory Factor-3/*metabolism
Apoptosis ; Cell Survival ; Cells, Cultured ; Granzymes/genetics ; HEK293 Cells ; Humans ; Interferon Regulatory Factor-3/genetics ; Mutation/genetics ; Perforin/metabolism ; Phosphorylation ; Proteolysis ; Signal Transduction
Czasopismo naukowe
Tytuł :
COVID-19 pneumonia: CD8 T and NK cells are decreased in number but compensatory increased in cytotoxic potential.
Autorzy :
Jiang Y; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Wei X; Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
Guan J; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Qin S; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Wang Z; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Lu H; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Qian J; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Wu L; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Chen Y; Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou, Medical University, Wenzhou 325000, China.
Chen Y; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: .
Lin X; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: .
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2020 Sep; Vol. 218, pp. 108516. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus/*pathogenicity
Coronavirus Infections/*diagnosis
Granzymes/*genetics
Killer Cells, Natural/*immunology
Perforin/*genetics
Pneumonia, Viral/*diagnosis
T-Lymphocytes, Cytotoxic/*immunology
Aged ; Aged, 80 and over ; Betacoronavirus/immunology ; Biomarkers/blood ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/virology ; COVID-19 ; COVID-19 Testing ; Case-Control Studies ; China ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/blood ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Disease Progression ; Female ; Gene Expression ; Granzymes/blood ; Granzymes/immunology ; Humans ; Killer Cells, Natural/pathology ; Killer Cells, Natural/virology ; Lymphocyte Activation ; Lymphocyte Count ; Male ; Middle Aged ; Pandemics ; Perforin/blood ; Perforin/immunology ; Pneumonia, Viral/blood ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Prognosis ; ROC Curve ; SARS-CoV-2 ; Severity of Illness Index ; T-Lymphocytes, Cytotoxic/pathology ; T-Lymphocytes, Cytotoxic/virology
Czasopismo naukowe
Tytuł :
Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.
Autorzy :
Sutton VR; Rosie Lew Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street Melbourne 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne 3050, Australia.
Andoniou C; Infection and Immunity Program, Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia; Centre for Experimental Immunology, Lions Eye Institute, Perth, Western Australia 6009, Australia.
Leeming MG; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science & Biotechnology Institute, Australia; School of Chemistry, The University of Melbourne, Melbourne, Australia.
House CM; Rosie Lew Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street Melbourne 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne 3050, Australia.
Watt SV; Rosie Lew Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street Melbourne 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne 3050, Australia.
Verschoor S; Rosie Lew Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street Melbourne 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne 3050, Australia.
Ciccone A; Rosie Lew Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street Melbourne 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne 3050, Australia.
Voskoboinik I; Rosie Lew Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street Melbourne 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne 3050, Australia.
Degli-Esposti M; Infection and Immunity Program, Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia; Centre for Experimental Immunology, Lions Eye Institute, Perth, Western Australia 6009, Australia.
Trapani JA; Rosie Lew Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street Melbourne 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne 3050, Australia. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2020 Sep; Vol. 1868 (9), pp. 140457. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Granzymes/*chemistry
Granzymes/*metabolism
Muromegalovirus/*immunology
Peptides/*metabolism
Animals ; Apoptosis ; Caspases/metabolism ; Cell Death ; Cell Line ; Disease Models, Animal ; Female ; Granzymes/genetics ; Herpesviridae Infections/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism ; Peptides/immunology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Substrate Specificity ; T-Lymphocytes, Cytotoxic/immunology ; Viral Proteins/immunology ; Viral Proteins/metabolism ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes.
Autorzy :
Janiszewski T; Wroclaw University of Science and Technology, Department of Chemical Biology and Bioimaging, Wroclaw, Poland.
Kołt S; Wroclaw University of Science and Technology, Department of Chemical Biology and Bioimaging, Wroclaw, Poland.
Kaiserman D; Monash University, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Clayton, VIC, Australia.
Snipas SJ; Sanford-Burnham Prebys Medical Discovery Institute, NCI-designated Cancer Center, La Jolla, California, USA.
Li S; University Medical Center Utrecht, Department of Pathology, Utrecht, The Netherlands.
Kulbacka J; Wroclaw Medical University, Department of Molecular and Cellular Biology, Wroclaw, Poland.
Saczko J; Wroclaw Medical University, Department of Molecular and Cellular Biology, Wroclaw, Poland.
Bovenschen N; University Medical Center Utrecht, Department of Pathology, Utrecht, The Netherlands.
Salvesen G; Sanford-Burnham Prebys Medical Discovery Institute, NCI-designated Cancer Center, La Jolla, California, USA.
Drąg M; Wroclaw University of Science and Technology, Department of Chemical Biology and Bioimaging, Wroclaw, Poland.; Sanford-Burnham Prebys Medical Discovery Institute, NCI-designated Cancer Center, La Jolla, California, USA.
Bird PI; Monash University, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Clayton, VIC, Australia.
Kasperkiewicz P; Wroclaw University of Science and Technology, Department of Chemical Biology and Bioimaging, Wroclaw, Poland .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Jul 10; Vol. 295 (28), pp. 9567-9582. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Granzymes*/chemistry
Granzymes*/metabolism
Optical Imaging*
Fluorescent Dyes/*chemistry
Peptides/*chemistry
T-Lymphocytes/*enzymology
Cell Line, Tumor ; Humans
Czasopismo naukowe
Tytuł :
Granzyme B PET Imaging of the Innate Immune Response.
Autorzy :
Capaccione KM; Department of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Doubrovin M; Department of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Bhatt N; Department of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Mintz A; Department of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Molotkov A; Department of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jul 07; Vol. 25 (13). Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article
MeSH Terms :
Granzymes*/chemistry
Granzymes*/pharmacology
Lipopolysaccharides*
Positron-Emission Tomography*
Immunity, Innate/*drug effects
Animals ; Inflammation/chemically induced ; Inflammation/diagnostic imaging ; Inflammation/immunology ; Mice ; Mice, Mutant Strains
Czasopismo naukowe
Tytuł :
Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.
Autorzy :
Santiago L; Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), 50009 Zaragoza, Spain.
Castro M; Department of Pharmacology and Physiology, Faculty of Health and Sports Sciences, University of Zaragoza, 22002 Huesca, Spain.
Sanz-Pamplona R; Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERESP, L'Hospitalet de Llobregat, Barcelona, Spain.
Garzón M; Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), 50009 Zaragoza, Spain.
Ramirez-Labrada A; Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), 50009 Zaragoza, Spain.
Tapia E; Animal Unit, University of Zaragoza, 50009 Zaragoza, Spain.
Moreno V; Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERESP, L'Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.
Layunta E; Department of Pharmacology and Physiology, Faculty of Veterinary, University of Zaragoza, 50013 Zaragoza, Spain.
Gil-Gómez G; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), 08003 Barcelona.
Garrido M; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), 08003 Barcelona.
Peña R; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), 08003 Barcelona.
Lanuza PM; Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), 50009 Zaragoza, Spain.
Comas L; Instituto de Carboquímica ICB-CSIC, 50018 Zaragoza, Spain.
Jaime-Sanchez P; Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), 50009 Zaragoza, Spain.
Uranga-Murillo I; Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), 50009 Zaragoza, Spain.
Del Campo R; Department of Microbiology, University Hospital Ramón y Cajal & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain.
Pelegrín P; Unidad de Inflamación Molecular y Cirugía Experimental, Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
Camerer E; Université de Paris, Paris Cardiovascular Research Center, INSERM U970, 75015 Paris, France.
Martínez-Lostao L; Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), 50009 Zaragoza, Spain; Department of Immunology, University Clinic Hospital Lozano Blesa, 50009, Zaragoza, Spain and Department of Pathology, University Clinic Hospital Lozano Blesa, University of Zaragoza, IIS Aragón, CIBEREHD, 50009 Zaragoza, Spain; Nanoscience Institute of Aragon (INA), University of Zaragoza, 50018 Zaragoza, Spain; Department Biochemistry and Molecular and Cell Biology and Department Microbiology, Preventive Medicine and Public Health, University of Zaragoza, 50009 Zaragoza, Spain.
Muñoz G; Department of Immunology, University Clinic Hospital Lozano Blesa, 50009, Zaragoza, Spain and Department of Pathology, University Clinic Hospital Lozano Blesa, University of Zaragoza, IIS Aragón, CIBEREHD, 50009 Zaragoza, Spain.
Uranga JA; Department of Basis Health Sciences, Faculty of Health Sciences, Rey Juan Carlos University, 28922 Madrid, Spain.
Alcalde A; Department of Pharmacology and Physiology, Faculty of Veterinary, University of Zaragoza, 50013 Zaragoza, Spain.
Galvez EM; Instituto de Carboquímica ICB-CSIC, 50018 Zaragoza, Spain.
Ferrandez A; Service of Digestive Diseases, University Clinic Hospital Lozano Blesa, University of Zaragoza, IIS Aragón, CIBEREHD, Zaragoza, Spain.
Bird PI; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University 3800 Melbourne, Australia.
Metkar S; XEME Biopharma Inc., Lombard, IL, USA.
Arias MA; Instituto de Carboquímica ICB-CSIC, 50018 Zaragoza, Spain. Electronic address: .
Pardo J; Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), 50009 Zaragoza, Spain; Aragon I+D Foundation (ARAID), Zaragoza, Spain; Nanoscience Institute of Aragon (INA), University of Zaragoza, 50018 Zaragoza, Spain; Department Biochemistry and Molecular and Cell Biology and Department Microbiology, Preventive Medicine and Public Health, University of Zaragoza, 50009 Zaragoza, Spain; CIBER-BBN, Madrid, Spain. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2020 Jul 07; Vol. 32 (1), pp. 107847.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis/*pathology
Colon/*pathology
Colorectal Neoplasms/*enzymology
Colorectal Neoplasms/*pathology
Extracellular Space/*enzymology
Granzymes/*metabolism
Inflammation/*pathology
Acute Disease ; Animals ; Azoxymethane ; Carcinogenesis/genetics ; Chronic Disease ; Colorectal Neoplasms/genetics ; Cyclooxygenase 2/metabolism ; Cytokines/metabolism ; Dextran Sulfate ; Disease Progression ; Granzymes/antagonists & inhibitors ; Granzymes/genetics ; Humans ; Inflammasomes/metabolism ; Inflammation Mediators/metabolism ; Interleukin-6/biosynthesis ; Mice, Knockout ; NF-kappa B/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Secretome analysis reveals upregulated granzyme B in human androgen-repressed prostate cancer cells with mesenchymal and invasive phenotype.
Autorzy :
Bou-Dargham MJ; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, United States of America.
Sang QA; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, United States of America.; Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Aug 07; Vol. 15 (8), pp. e0237222. Date of Electronic Publication: 2020 Aug 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Androgens/*metabolism
Granzymes/*genetics
Neoplasm Invasiveness/*genetics
Prostatic Neoplasms/*genetics
Cell Line, Tumor ; Cell Survival ; Epithelial-Mesenchymal Transition ; Gene Expression Regulation, Neoplastic ; Granzymes/metabolism ; Humans ; Male ; Neoplasm Invasiveness/pathology ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Up-Regulation
Czasopismo naukowe
Tytuł :
Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B.
Autorzy :
Qian Q; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health (NJH), Denver, Colorado, USA.
Chowdhury BP; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health (NJH), Denver, Colorado, USA.
Sun Z; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health (NJH), Denver, Colorado, USA.
Lenberg J; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health (NJH), Denver, Colorado, USA.
Alam R; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health (NJH), Denver, Colorado, USA.; Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Vivier E; Innate Pharma Research Labs, Innate Pharma, Marseille, France.; Centre d'Immunologie de Marseille-Luminy, CNRS, INSERM, Aix Marseille University, Marseille, France.; Service d'Immunologie, Marseille Immunopole, Hôpital de la Timone, Assistance Publique des Hôpitaux de Marseille, Marseille, France.
Gorska MM; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health (NJH), Denver, Colorado, USA.; Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Aug 03; Vol. 130 (8), pp. 4133-4151.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Asthma/*immunology
Granzymes/*immunology
Killer Cells, Natural/*immunology
Maternal Exposure/*adverse effects
Prenatal Exposure Delayed Effects/*immunology
Vehicle Emissions/*toxicity
Animals ; Asthma/genetics ; Asthma/pathology ; Disease Models, Animal ; Female ; Granzymes/deficiency ; Humans ; Interleukin-13/genetics ; Interleukin-13/immunology ; Interleukin-17/genetics ; Interleukin-17/immunology ; Killer Cells, Natural/pathology ; Mice ; Mice, Knockout ; Pregnancy ; Prenatal Exposure Delayed Effects/genetics ; Prenatal Exposure Delayed Effects/pathology ; Th2 Cells/immunology ; Th2 Cells/pathology
Czasopismo naukowe
Tytuł :
Nicotine exhausts CD8 T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression.
Autorzy :
Cheng CC; Radiation Biology Research Center, Institute for Radiological Research, Chang Gung Memorial Hospital, Chang Gung University, Linkou, Taiwan.
Lin HC; Division of Gastroenterology, Cheng Hsin General Hospital, Taipei, Taiwan.
Chiang YW; Division of Hematology and Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.; Department of Medical Research, Laboratory of Good Clinical Research Center, Mackay Memorial Hospital, Tamsui District, New Taipei City, Taiwan.
Chang J; Graduate Institute of Medical Sciences, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Sie ZL; Radiation Biology Research Center, Institute for Radiological Research, Chang Gung Memorial Hospital, Chang Gung University, Linkou, Taiwan.
Yang BL; Division of Gastroenterology, Cheng Hsin General Hospital, Taipei, Taiwan.
Lim KH; Division of Hematology and Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.; Department of Medical Research, Laboratory of Good Clinical Research Center, Mackay Memorial Hospital, Tamsui District, New Taipei City, Taiwan.; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
Peng CL; Institute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan.
Ho AS; Division of Gastroenterology, Cheng Hsin General Hospital, Taipei, Taiwan. .
Chang YF; Division of Hematology and Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan. .; Department of Medical Research, Laboratory of Good Clinical Research Center, Mackay Memorial Hospital, Tamsui District, New Taipei City, Taiwan. .; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 May; Vol. 70 (5), pp. 1351-1364. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma of Lung/*metabolism
CD8-Positive T-Lymphocytes/*immunology
Interleukin-2 Receptor beta Subunit/*metabolism
MicroRNAs/*genetics
Nicotine/*metabolism
A549 Cells ; Animals ; Cell Line, Tumor ; Cigarette Smoking/adverse effects ; Gene Expression Regulation, Neoplastic ; Granzymes/genetics ; Granzymes/metabolism ; Humans ; Interleukin-2 Receptor beta Subunit/genetics ; Male ; Mice ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
MiR-518a-5p Targets GZMB to Extenuate Vascular Endothelial Cell Injury Induced by Hypoxia-Reoxygenation and Thereby Improves Myocardial Ischemia.
Autorzy :
Yang H; Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University.
Su J; Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University.
Meng W; Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University.
Chen X; Department of Ultrasound, The First Affiliated Hospital of Harbin Medical University.
Xu Y; Editorial Department, Journal of Harbin Medical University.
Sun B; Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University.
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Źródło :
International heart journal [Int Heart J] 2021 May 29; Vol. 62 (3), pp. 658-665. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Endothelial Cells/*metabolism
Granzymes/*metabolism
MicroRNAs/*metabolism
Myocardial Reperfusion Injury/*metabolism
Human Umbilical Vein Endothelial Cells ; Humans ; Hypoxia/metabolism
Czasopismo naukowe
Tytuł :
Circulating CD4 T Cells Elicited by Endemic Coronaviruses Display Vast Disparities in Abundance and Functional Potential Linked to Antigen Specificity and Age.
Autorzy :
Richards KA; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Glover M; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Crawford JC; Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Thomas PG; Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
White C; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Sant AJ; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2021 May 20; Vol. 223 (9), pp. 1555-1563.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
CD4-Positive T-Lymphocytes/*virology
COVID-19/*immunology
Coronavirus Infections/*immunology
Epitopes, T-Lymphocyte/*immunology
SARS-CoV-2/*immunology
Adult ; Aged ; Coronavirus Envelope Proteins/immunology ; Coronavirus M Proteins/immunology ; Coronavirus Nucleocapsid Proteins/immunology ; Cross Reactions ; Granzymes/metabolism ; Humans ; Immunologic Memory ; Interferon-gamma/metabolism ; Interleukin-2/metabolism ; Middle Aged ; Spike Glycoprotein, Coronavirus/immunology
Czasopismo naukowe
Tytuł :
A combination of the percentages of IFN-γ B cells is associated with acute hepatic rejection: a case control study.
Autorzy :
Zhu JQ; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Wang J; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Li XL; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Xu WL; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Lv SC; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Zhao X; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Lang R; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China. .
He Q; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China. .
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Źródło :
Journal of translational medicine [J Transl Med] 2021 May 01; Vol. 19 (1), pp. 187. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes*
Graft Rejection*
Case-Control Studies ; Granzymes ; Liver
Czasopismo naukowe
Tytuł :
Tertiary lymphoid structures show infiltration of effective tumor-resident T cells in gastric cancer.
Autorzy :
Mori T; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Tanaka H; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Suzuki S; Department of Molecular Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Deguchi S; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Yamakoshi Y; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Yoshii M; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Miki Y; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Tamura T; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Toyokawa T; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Lee S; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Muguruma K; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Wanibuchi H; Department of Molecular Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Ohira M; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 May; Vol. 112 (5), pp. 1746-1757. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, CD*
Integrin alpha Chains*
CD8-Positive T-Lymphocytes/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Stomach Neoplasms/*immunology
Tertiary Lymphoid Structures/*immunology
Tumor Microenvironment/*immunology
Aged ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; Female ; Granzymes/metabolism ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunity, Cellular ; Interferon-gamma/metabolism ; Kaplan-Meier Estimate ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Prognosis ; Programmed Cell Death 1 Receptor/metabolism ; ROC Curve ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy ; Tertiary Lymphoid Structures/metabolism
Czasopismo naukowe
Tytuł :
Granzyme B in peripheral blood mononuclear cells as a measure of cell-mediated immune response in paraneoplastic neurological syndromes and malignancy.
Autorzy :
Zaborowski MP; Department of Gynecology, Obstetrics and Gynecologic Oncology, Division of Gynecologic Oncology, Poznan University of Medical Sciences, Poznań, Poland. .
Stefens-Stawna P; Department of Neurology, Poznan University of Medical Science, Poznań, Poland.
Osztynowicz K; Department of Neurochemistry and Neuropathology, Chair of Neurology, Poznan University of Medical Sciences, Poznań, Poland.
Piorunek T; Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, Poznań, Poland.
Batura-Gabryel H; Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, Poznań, Poland.
Dyzmann-Sroka A; Cancer Registry, Greater Poland Cancer Centre, Poznań, Poland.; Department of Tumor Pathology and Prophylaxis, Poznan University of Medical Sciences, Poznań, Poland.
Kozubski W; Department of Neurology, Poznan University of Medical Science, Poznań, Poland.
Nowak-Markwitz E; Department of Gynecology, Obstetrics and Gynecologic Oncology, Division of Gynecologic Oncology, Poznan University of Medical Sciences, Poznań, Poland.
Michalak S; Department of Neurochemistry and Neuropathology, Chair of Neurology, Poznan University of Medical Sciences, Poznań, Poland.; Neuroimmunological Diseases Unit, Polish Academy of Sciences, Warsaw, Poland.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 May; Vol. 70 (5), pp. 1277-1289. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Granzymes/*metabolism
Leukocytes, Mononuclear/*metabolism
Lung Neoplasms/*diagnosis
Ovarian Neoplasms/*diagnosis
Paraneoplastic Syndromes, Nervous System/*diagnosis
Aged ; Aged, 80 and over ; Cytotoxicity, Immunologic ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunity, Cellular ; Male ; Middle Aged ; Tumor Escape
Czasopismo naukowe
Tytuł :
DNA hypomethylating agents increase activation and cytolytic activity of CD8 T cells.
Autorzy :
Loo Yau H; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Bell E; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Ettayebi I; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
de Almeida FC; Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, Brazil; Instituto de Investigação em Imunologia, Institutos Nacionais de Ciência e Tecnologia (INCT-iii), São Paulo 05403-900, Brazil.
Boukhaled GM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Shen SY; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Allard D; Centre de recherche du Centre Hospitalier de l'Université de Montréal et Institut du Cancer de Montréal, Montréal, QC H2X 0A9, Canada; Faculté de Pharmacie, Université de Montréal, Montréal, QC H3T 1J4, Canada.
Morancho B; Preclinical Research Program, Vall d'Hebron Institute of Oncology (VHIO) and CIBERONC, 08035 Barcelona, Spain.
Marhon SA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Ishak CA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Gonzaga IM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
da Silva Medina T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Translational Immuno-oncology Laboratory, A.C. Camargo Cancer Center, São Paulo 01509-001, Brazil.
Singhania R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Chakravarthy A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Chen R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Mehdipour P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Pommey S; Centre de recherche du Centre Hospitalier de l'Université de Montréal et Institut du Cancer de Montréal, Montréal, QC H2X 0A9, Canada.
Klein C; Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Wagistrasse 10, 8952 Schlieren, Switzerland.
Amarante-Mendes GP; Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, Brazil; Instituto de Investigação em Imunologia, Institutos Nacionais de Ciência e Tecnologia (INCT-iii), São Paulo 05403-900, Brazil.
Roulois D; UMR U1236, INSERM, Université de Rennes 1, EFS, 35000 Rennes, France.
Arribas J; Preclinical Research Program, Vall d'Hebron Institute of Oncology (VHIO) and CIBERONC, 08035 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain; Cancer Research Program, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain.
Stagg J; Centre de recherche du Centre Hospitalier de l'Université de Montréal et Institut du Cancer de Montréal, Montréal, QC H2X 0A9, Canada; Faculté de Pharmacie, Université de Montréal, Montréal, QC H3T 1J4, Canada.
Brooks DG; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
De Carvalho DD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Apr 01; Vol. 81 (7), pp. 1469-1483.e8. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
CpG Islands/*immunology
DNA Methylation/*drug effects
Decitabine/*pharmacology
Granzymes/*immunology
Lymphocyte Activation/*drug effects
DNA Methylation/immunology ; Humans ; NFATC Transcription Factors/immunology ; Perforin/immunology
Czasopismo naukowe
Tytuł :
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.
Autorzy :
Zhou Z; Research Unit of Pyroptosis and Immunity, Chinese Academy of Medical Sciences and National Institute of Biological Sciences, Beijing, Beijing 102206, China.; National Institute of Biological Sciences, Beijing, Beijing 102206, China.
He H; Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, School of Life Sciences, Tsinghua University, Beijing 100084, China.; National Institute of Biological Sciences, Beijing, Beijing 102206, China.
Wang K; National Institute of Biological Sciences, Beijing, Beijing 102206, China.
Shi X; National Institute of Biological Sciences, Beijing, Beijing 102206, China.
Wang Y; Research Unit of Pyroptosis and Immunity, Chinese Academy of Medical Sciences and National Institute of Biological Sciences, Beijing, Beijing 102206, China.; National Institute of Biological Sciences, Beijing, Beijing 102206, China.
Su Y; National Institute of Biological Sciences, Beijing, Beijing 102206, China.
Wang Y; Department of Molecular and Immunology and Department of Bio-therapeutics, Chinese PLA General Hospital, Beijing 100853, China.
Li D; National Institute of Biological Sciences, Beijing, Beijing 102206, China.
Liu W; Research Unit of Pyroptosis and Immunity, Chinese Academy of Medical Sciences and National Institute of Biological Sciences, Beijing, Beijing 102206, China.; National Institute of Biological Sciences, Beijing, Beijing 102206, China.
Zhang Y; Gracell Biotechnologies, Shanghai 200233, China.
Shen L; Gracell Biotechnologies, Shanghai 200233, China.
Han W; Department of Molecular and Immunology and Department of Bio-therapeutics, Chinese PLA General Hospital, Beijing 100853, China.
Shen L; Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing 100142, China.
Ding J; National Institute of Biological Sciences, Beijing, Beijing 102206, China.; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS), Beijing 100101, China.
Shao F; Research Unit of Pyroptosis and Immunity, Chinese Academy of Medical Sciences and National Institute of Biological Sciences, Beijing, Beijing 102206, China. .; National Institute of Biological Sciences, Beijing, Beijing 102206, China.; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS), Beijing 100101, China.; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.
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Źródło :
Science (New York, N.Y.) [Science] 2020 May 29; Vol. 368 (6494). Date of Electronic Publication: 2020 Apr 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Granzymes/*metabolism
Killer Cells, Natural/*immunology
Neoplasm Proteins/*metabolism
Pore Forming Cytotoxic Proteins/*metabolism
Pyroptosis/*immunology
T-Lymphocytes, Cytotoxic/*enzymology
Animals ; Granzymes/chemistry ; HEK293 Cells ; Humans ; Interferon-gamma ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Neoplasms/immunology ; Neoplasms/pathology ; Pore Forming Cytotoxic Proteins/chemistry ; Pore Forming Cytotoxic Proteins/genetics ; Protein Domains ; Proteolysis
Czasopismo naukowe
Tytuł :
Mapping the extent of heterogeneity of human CCR5+ CD4+ T cells in peripheral blood and lymph nodes.
Autorzy :
Zaunders J; Centre for Applied Medical Research, St Vincent's Hospital Sydney, Darlinghurst.
Munier CML; Kirby Institute, UNSW Sydney.
McGuire HM; Ramaciotti Facility for Human Systems Biology.; Charles Perkins Centre.; Faculty of Medicine and Health, Discipline of Pathology, The University of Sydney, Sydney.
Law H; Kirby Institute, UNSW Sydney.
Howe A; Kirby Institute, UNSW Sydney.
Xu Y; Kirby Institute, UNSW Sydney.
de St Groth BF; Ramaciotti Facility for Human Systems Biology.; Charles Perkins Centre.; Faculty of Medicine and Health, Discipline of Pathology, The University of Sydney, Sydney.
Schofield P; Garvan Institute of Medical Research, Sydney.
Christ D; Garvan Institute of Medical Research, Sydney.
Milner B; Medical Imaging Department, St Vincent's Hospital Sydney, Darlinghurst.
Obeid S; Medical Imaging Department, St Vincent's Hospital Sydney, Darlinghurst.
Dyer WB; Australian Red Cross Blood Service, Sydney.; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales.
Saksena NK; Epigene Australia Pty Ltd, Melbourne, Victoria, Australia.
Kelleher AD; Centre for Applied Medical Research, St Vincent's Hospital Sydney, Darlinghurst.; Kirby Institute, UNSW Sydney.
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Źródło :
AIDS (London, England) [AIDS] 2020 May 01; Vol. 34 (6), pp. 833-848.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes*
Granzymes*
HIV-1/*metabolism
Lymph Nodes/*pathology
Receptors, CCR5/*blood
Biopsy, Fine-Needle ; CD4 Lymphocyte Count ; HIV Infections ; HIV-1/genetics ; Humans ; Lymph Nodes/surgery ; Microarray Analysis ; T-Lymphocyte Subsets
Czasopismo naukowe
Tytuł :
Granzyme B is correlated with clinical outcome after PD-1 blockade in patients with stage IV non-small-cell lung cancer.
Autorzy :
Hurkmans DP; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands .; Department of Pulmonology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Basak EA; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Schepers N; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Oomen-De Hoop E; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Van der Leest CH; Department of Pulmonology, Amphia Hospital, Breda, The Netherlands.
El Bouazzaoui S; Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands.
Bins S; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Koolen SLW; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.; Departmemt of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.
Sleijfer S; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Van der Veldt AAM; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.; Department of Radiology & Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Debets R; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Van Schaik RHN; Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands.
Aerts JGJV; Department of Pulmonology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Mathijssen RHJ; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
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Źródło :
Journal for immunotherapy of cancer [J Immunother Cancer] 2020 May; Vol. 8 (1).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers, Tumor/*genetics
Carcinoma, Non-Small-Cell Lung/*drug therapy
Granzymes/*genetics
Immune Checkpoint Inhibitors/*pharmacology
Lung Neoplasms/*drug therapy
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/mortality ; Drug Resistance, Neoplasm/genetics ; Female ; Granzymes/blood ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Lung/immunology ; Lung/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/immunology ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Mutation ; Neoplasm Staging ; Nivolumab/pharmacology ; Nivolumab/therapeutic use ; Polymorphism, Single Nucleotide ; Prognosis ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Progression-Free Survival ; Prospective Studies ; Response Evaluation Criteria in Solid Tumors
Czasopismo naukowe
Tytuł :
Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.
Autorzy :
Shan L; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Li S; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Meeldijk J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Blijenberg B; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Hendriks A; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
van Boxtel KJWM; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
van den Berg SPH; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Groves IJ; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Potts M; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Svrlanska A; Institute of Clinical and Molecular Virology, University of Erlangen-Nuremberg, Erlangen, Germany.
Stamminger T; Institute for Virology, Ulm University Medical Center, Ulm, Germany.
Wills MR; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Bovenschen N; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Apr 13; Vol. 16 (4), pp. e1008426. Date of Electronic Publication: 2020 Apr 13 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytomegalovirus/*metabolism
Cytomegalovirus Infections/*enzymology
Granzymes/*metabolism
Immediate-Early Proteins/*metabolism
Killer Cells, Natural/*enzymology
Trans-Activators/*metabolism
Amino Acid Motifs ; Cytomegalovirus/genetics ; Cytomegalovirus Infections/virology ; Granzymes/genetics ; Host-Pathogen Interactions ; Humans ; Immediate-Early Proteins/genetics ; Proteolysis ; T-Lymphocytes, Cytotoxic/enzymology ; Trans-Activators/genetics
Czasopismo naukowe

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