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    Tytuł:
    Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease.
    Autorzy:
    Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. .
    Grassmann F; Institute of Human Genetics, University of Regensburg, Regensburg, Germany.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK.
    Brandl C; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Institute of Human Genetics, University of Regensburg, Regensburg, Germany.; Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany.
    Kiel C; Institute of Human Genetics, University of Regensburg, Regensburg, Germany.
    Günther F; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Statistical Consulting Unit StaBLab, Department of Statistics, Ludwig-Maximilians-Universität Munich, Munich, Germany.
    Strunz T; Institute of Human Genetics, University of Regensburg, Regensburg, Germany.
    Weidner L; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
    Zimmermann ME; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
    Korb CA; Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
    Poplawski A; Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
    Schuster AK; Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
    Müller-Nurasyid M; Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.; Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
    Peters A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.
    Rauscher FG; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig, Germany.; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig, Germany.
    Elze T; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig, Germany.; Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA.
    Horn K; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig, Germany.; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig, Germany.
    Scholz M; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig, Germany.; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig, Germany.
    Cañadas-Garre M; Centre for Public Health, Queen's University of Belfast, Belfast, UK.
    McKnight AJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK.
    Quinn N; Centre for Public Health, Queen's University of Belfast, Belfast, UK.
    Hogg RE; Centre for Public Health, Queen's University of Belfast, Belfast, UK.
    Küchenhoff H; Statistical Consulting Unit StaBLab, Department of Statistics, Ludwig-Maximilians-Universität Munich, Munich, Germany.
    Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
    Stark KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
    Weber BHF; Institute of Human Genetics, University of Regensburg, Regensburg, Germany.; Institute of Clinical Human Genetics, University Hospital Regensburg, Regensburg, Germany.
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    Źródło:
    BMC medical genomics [BMC Med Genomics] 2020 Aug 26; Vol. 13 (1), pp. 120. Date of Electronic Publication: 2020 Aug 26.
    Typ publikacji:
    Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Loci*
    Genetic Markers*
    Genetic Predisposition to Disease*
    Genome-Wide Association Study*
    Polymorphism, Single Nucleotide*
    Macular Degeneration/*genetics
    Macular Degeneration/*pathology
    Case-Control Studies ; Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors.
    Autorzy:
    Yang H; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Xuefu North Road 1, University Town, Fuzhou, 350122, China. .; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177, Stockholm, Sweden. .
    Holowko N; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177, Stockholm, Sweden.
    Grassmann F; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177, Stockholm, Sweden.
    Eriksson M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177, Stockholm, Sweden.
    Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177, Stockholm, Sweden.; Department of Oncology, South General Hospital, SE-11883, Stockholm, Sweden.
    Czene K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177, Stockholm, Sweden.
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    Źródło:
    BMC medicine [BMC Med] 2020 Aug 25; Vol. 18 (1), pp. 225. Date of Electronic Publication: 2020 Aug 25.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Breast Neoplasms/*etiology
    Genetic Pleiotropy/*genetics
    Genetic Predisposition to Disease/*genetics
    Hyperthyroidism/*complications
    Mammography/*methods
    Adult ; Breast Neoplasms/genetics ; Cohort Studies ; Female ; Humans ; Hyperthyroidism/pathology ; Risk Factors ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci.
    Autorzy:
    Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
    Brandl C; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany.; Institute of Human Genetics, University of Regensburg, Regensburg, Germany.
    Grassmann F; Institute of Human Genetics, University of Regensburg, Regensburg, Germany.
    Gorski M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
    Stark K; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
    Loss J; Medical Sociology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
    Weber BHF; Institute of Human Genetics, University of Regensburg, Regensburg, Germany.
    Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
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    Corporate Authors:
    International Age-related Macular Degeneration Genomics Consortium (IAMDGC)
    Źródło:
    PloS one [PLoS One] 2018 Mar 12; Vol. 13 (3), pp. e0194321. Date of Electronic Publication: 2018 Mar 12 (Print Publication: 2018).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Association Studies*
    Genetic Predisposition to Disease*
    Macular Degeneration/*genetics
    Age Factors ; Complement Factor H/genetics ; Female ; Genetic Loci ; High-Temperature Requirement A Serine Peptidase 1/genetics ; Humans ; Male ; Membrane Proteins/genetics ; Nerve Tissue Proteins/genetics ; Sex Factors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.
    Autorzy:
    Grassmann F; Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
    Kiel C; Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
    Zimmermann ME; Department of Genetic Epidemiology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
    Gorski M; Department of Genetic Epidemiology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
    Grassmann V; Institute of Medical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg, 93053, Germany.
    Stark K; Department of Genetic Epidemiology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
    Heid IM; Department of Genetic Epidemiology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
    Weber BH; Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany. .
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    Corporate Authors:
    International AMD Genomics Consortium (IAMDGC)
    Źródło:
    Genome medicine [Genome Med] 2017 Mar 27; Vol. 9 (1), pp. 29. Date of Electronic Publication: 2017 Mar 27.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
    MeSH Terms:
    Genetic Loci*
    Genetic Pleiotropy*
    Genetic Predisposition to Disease*
    Polymorphism, Single Nucleotide*
    Macular Degeneration/*genetics
    Female ; Genome-Wide Association Study ; Humans ; Macular Degeneration/metabolism ; Male
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD).
    Autorzy:
    Grassmann F; Institute of Human Genetics, University of Regensburg, Regensburg, 93053, Germany.
    Cantsilieris S; Centre for Eye Research, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
    Schulz-Kuhnt AS; Institute of Human Genetics, University of Regensburg, Regensburg, 93053, Germany.
    White SJ; Leiden University Medical Center, Leiden, The Netherlands.
    Richardson AJ; Centre for Eye Research, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
    Hewitt AW; Centre for Eye Research, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.; School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.
    Vote BJ; School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.
    Schmied D; Institute of Human Genetics, University of Regensburg, Regensburg, 93053, Germany.
    Guymer RH; Centre for Eye Research, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
    Weber BH; Institute of Human Genetics, University of Regensburg, Regensburg, 93053, Germany. .
    Baird PN; Centre for Eye Research, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia. .
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    Źródło:
    Journal of neuroinflammation [J Neuroinflammation] 2016 Apr 18; Vol. 13 (1), pp. 81. Date of Electronic Publication: 2016 Apr 18.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Dosage*
    Complement C4a/*genetics
    Genetic Predisposition to Disease/*genetics
    Macular Degeneration/*genetics
    Alleles ; Cohort Studies ; Female ; Genome-Wide Association Study ; Genotype ; Humans ; Male ; Multiplex Polymerase Chain Reaction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration.
    Autorzy:
    Grassmann F; Institute of Human Genetics, University of Regensburg, Regensburg, D-93053, Germany.
    Fleckenstein M; Department of Ophthalmology, University of Bonn, Bonn, D-53127, Germany.
    Chew EY; National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1204, United States of America.
    Strunz T; Institute of Human Genetics, University of Regensburg, Regensburg, D-93053, Germany.
    Schmitz-Valckenberg S; Department of Ophthalmology, University of Bonn, Bonn, D-53127, Germany.
    Göbel AP; Department of Ophthalmology, University of Bonn, Bonn, D-53127, Germany.
    Klein ML; Macular Degeneration Center, Casey Eye Institute, Oregon Health & Science University, and Devers Eye Institute, Portland, Oregon 97239, United States of America.
    Ratnapriya R; National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1204, United States of America.
    Swaroop A; National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1204, United States of America.
    Holz FG; Department of Ophthalmology, University of Bonn, Bonn, D-53127, Germany.
    Weber BH; Institute of Human Genetics, University of Regensburg, Regensburg, D-93053, Germany.
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    Źródło:
    PloS one [PLoS One] 2015 May 11; Vol. 10 (5), pp. e0126636. Date of Electronic Publication: 2015 May 11 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Association Studies*
    Genetic Predisposition to Disease*
    Geographic Atrophy/*diagnosis
    Geographic Atrophy/*genetics
    Aged ; Aged, 80 and over ; Alleles ; Disease Progression ; Fluorescein Angiography ; Follow-Up Studies ; Genotype ; Humans ; Proteins/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Modelling the genetic risk in age-related macular degeneration.
    Autorzy:
    Grassmann F; Institute of Human Genetics, University of Regensburg, Regensburg, Germany.
    Fritsche LG
    Keilhauer CN
    Heid IM
    Weber BH
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    Źródło:
    PloS one [PLoS One] 2012; Vol. 7 (5), pp. e37979. Date of Electronic Publication: 2012 May 30.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Models, Genetic*
    Genetic Predisposition to Disease/*genetics
    Macular Degeneration/*genetics
    Aged ; Aged, 80 and over ; Aging/genetics ; Case-Control Studies ; Female ; Genetic Loci/genetics ; Genotyping Techniques ; Humans ; Linkage Disequilibrium/genetics ; Male ; Polymorphism, Single Nucleotide/genetics ; Sex Characteristics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-7 z 7

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