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Wyświetlanie 1-12 z 12
Tytuł :
A phase I trial of single-agent reolysin in patients with relapsed multiple myeloma.
Autorzy :
Sborov DW; Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Nuovo GJ; Phylogeny, Inc., Columbus, Ohio.
Stiff A; College of Medicine, The Ohio State University, Columbus, Ohio.
Mace T; Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Lesinski GB; Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Benson DM Jr; Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Efebera YA; Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Rosko AE; Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Pichiorri F; Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Grever MR; Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Hofmeister CC; Department of Internal Medicine, The Ohio State University, Columbus, Ohio. .
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2014 Dec 01; Vol. 20 (23), pp. 5946-55. Date of Electronic Publication: 2014 Oct 07.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Oncolytic Virotherapy*/adverse effects
Oncolytic Viruses*/genetics
Oncolytic Viruses*/immunology
Retroviridae*
Multiple Myeloma/*pathology
Multiple Myeloma/*therapy
Aged ; Antibodies, Viral/immunology ; Biomarkers ; Cell Adhesion Molecules/metabolism ; Cell Line, Tumor ; Chromosomal Proteins, Non-Histone/metabolism ; Female ; Gene Expression ; Humans ; Male ; Middle Aged ; Multiple Myeloma/etiology ; Neoplasm Staging ; RNA, Viral ; Receptors, Cell Surface/metabolism ; Recurrence ; Treatment Outcome ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphocytic leukemia patients treated with flavopiridol.
Autorzy :
Ji J; The Comprehensive Cancer Center, College of Pharmacy, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA.
Mould DR
Blum KA
Ruppert AS
Poi M
Zhao Y
Johnson AJ
Byrd JC
Grever MR
Phelps MA
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2013 Mar 01; Vol. 19 (5), pp. 1269-80. Date of Electronic Publication: 2013 Jan 08.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Models, Biological*
Antineoplastic Agents/*therapeutic use
Flavonoids/*therapeutic use
Leukemia, Lymphocytic, Chronic, B-Cell/*drug therapy
Piperidines/*therapeutic use
Tumor Lysis Syndrome/*epidemiology
Antineoplastic Agents/pharmacokinetics ; Female ; Flavonoids/pharmacokinetics ; Follow-Up Studies ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Male ; Maximum Tolerated Dose ; Neoplasm Recurrence, Local ; Piperidines/pharmacokinetics ; Prevalence ; Prognosis ; Tissue Distribution ; Tumor Lysis Syndrome/etiology ; United States/epidemiology
Czasopismo naukowe
Tytuł :
Dual targeting of the cyclin/Rb/E2F and mitochondrial pathways in mantle cell lymphoma with the translation inhibitor silvestrol.
Autorzy :
Alinari L; Department of Internal Medicine, College of Medicine, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Prince CJ
Edwards RB
Towns WH
Mani R
Lehman A
Zhang X
Jarjoura D
Pan L
Kinghorn AD
Grever MR
Baiocchi RA
Lucas DM
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2012 Sep 01; Vol. 18 (17), pp. 4600-11. Date of Electronic Publication: 2012 Jul 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cyclin D1*/genetics
Cyclin D1*/metabolism
E2F1 Transcription Factor*/genetics
E2F1 Transcription Factor*/metabolism
Lymphoma, Mantle-Cell*/genetics
Lymphoma, Mantle-Cell*/metabolism
Lymphoma, Mantle-Cell*/pathology
Lymphoma, Mantle-Cell*/therapy
Triterpenes/*pharmacology
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Metabolic Networks and Pathways ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Retinoblastoma Protein/genetics ; Retinoblastoma Protein/metabolism ; Signal Transduction/drug effects ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents.
Autorzy :
Dancey JE; Ohio State University, Columbus, Ohio, USA. />Dobbin KK
Groshen S
Jessup JM
Hruszkewycz AH
Koehler M
Parchment R
Ratain MJ
Shankar LK
Stadler WM
True LD
Gravell A
Grever MR
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Corporate Authors :
Biomarkers Task Force of the NCI Investigational Drug Steering Committee
Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2010 Mar 15; Vol. 16 (6), pp. 1745-55. Date of Electronic Publication: 2010 Mar 09.
Typ publikacji :
Journal Article; Practice Guideline; Research Support, N.I.H., Extramural
MeSH Terms :
Research Design*
Biomarkers, Tumor/*analysis
Clinical Trials as Topic/*methods
Clinical Trials as Topic/*standards
Drugs, Investigational/*standards
Neoplasms/*drug therapy
Pharmacy and Therapeutics Committee/*organization & administration
Endpoint Determination ; Humans ; National Cancer Institute (U.S.) ; Neoplasms/chemistry ; Safety ; United States
Czasopismo naukowe
Tytuł :
A phase I and pharmacokinetic study of weekly oxaliplatin followed by paclitaxel in patients with solid tumors.
Autorzy :
Bekaii-Saab TS; Division of Hematology and Oncology, The Ohio State University, A434B Starling Loving Hall, 320 West 10th Avenue, Columbus, OH 43210, USA.
Liu J
Chan KK
Balcerzak SP
Ivy PS
Grever MR
Kraut EH
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2008 Jun 01; Vol. 14 (11), pp. 3434-40.
Typ publikacji :
Clinical Trial, Phase I; Historical Article; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Antineoplastic Combined Chemotherapy Protocols/*pharmacokinetics
Neoplasms/*drug therapy
Adult ; Aged ; Area Under Curve ; Drug Administration Schedule ; Female ; History, 17th Century ; Humans ; Male ; Maximum Tolerated Dose ; Organoplatinum Compounds/administration & dosage ; Organoplatinum Compounds/adverse effects ; Oxaliplatin ; Paclitaxel/administration & dosage ; Paclitaxel/adverse effects
Czasopismo naukowe
Tytuł :
Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity.
Autorzy :
Hussain SR; Division of Hematology-Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Cheney CM
Johnson AJ
Lin TS
Grever MR
Caligiuri MA
Lucas DM
Byrd JC
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2007 Apr 01; Vol. 13 (7), pp. 2144-50.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytotoxicity, Immunologic*/drug effects
Antibodies, Monoclonal/*pharmacology
Antineoplastic Agents/*pharmacology
Apoptosis/*physiology
Leukemia, Lymphoid/*metabolism
Neoplasm Proteins/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
Antibodies, Monoclonal, Murine-Derived ; Apoptosis/drug effects ; Blotting, Western ; Cell Line, Tumor ; Complement System Proteins ; Down-Regulation ; Flow Cytometry ; Humans ; Membrane Potentials/drug effects ; Mitochondrial Membranes/metabolism ; Mitochondrial Membranes/pathology ; Myeloid Cell Leukemia Sequence 1 Protein ; Neoplasm Proteins/drug effects ; Polymerase Chain Reaction ; Proto-Oncogene Proteins c-bcl-2/drug effects ; RNA, Small Interfering ; Rituximab ; Transfection
Czasopismo naukowe
Tytuł :
Phase I study of low-dose interleukin-2, fludarabine, and cyclophosphamide for previously untreated indolent lymphoma and chronic lymphocytic leukemia.
Autorzy :
Kasamon YL; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA. />Flinn IW
Grever MR
Diehl LF
Garrett-Mayer E
Goodman SN
Lucas MS
Byrd JC
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2005 Dec 01; Vol. 11 (23), pp. 8413-7.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Leukemia, Lymphocytic, Chronic, B-Cell/*drug therapy
Lymphoma, Follicular/*drug therapy
Adult ; CD4 Lymphocyte Count ; Cyclophosphamide/administration & dosage ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Injections, Subcutaneous ; Interleukin-2/administration & dosage ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Longitudinal Studies ; Lymphoma, Follicular/immunology ; Lymphoma, Follicular/pathology ; Male ; Middle Aged ; Vidarabine/administration & dosage ; Vidarabine/analogs & derivatives
Czasopismo naukowe
Tytuł :
Treatment of relapsed chronic lymphocytic leukemia by 72-hour continuous infusion or 1-hour bolus infusion of flavopiridol: results from Cancer and Leukemia Group B study 19805.
Autorzy :
Byrd JC; Division of Hematology-Oncology, Department of Medicine, The Ohio State University, Columbus, Ohio 43210, USA. />Peterson BL
Gabrilove J
Odenike OM
Grever MR
Rai K
Larson RA
Pokaż więcej
Corporate Authors :
Cancer and Leukemia Group B
Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2005 Jun 01; Vol. 11 (11), pp. 4176-81.
Typ publikacji :
Clinical Trial; Clinical Trial, Phase II; Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Flavonoids/*therapeutic use
Leukemia, Lymphocytic, Chronic, B-Cell/*drug therapy
Piperidines/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Drug Administration Schedule ; Female ; Flavonoids/administration & dosage ; Flavonoids/adverse effects ; Humans ; Infusion Pumps ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Neutropenia/chemically induced ; Piperidines/administration & dosage ; Piperidines/adverse effects ; Survival Analysis ; Thrombocytopenia/chemically induced ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Combination immunotherapy of B-cell non-Hodgkin's lymphoma with rituximab and interleukin-2: a preclinical and phase I study.
Autorzy :
Eisenbeis CF; Division of Hematology/Oncology, Comprehensive Cancer Center, and Center for Biostatistics, The Ohio State University, Columbus, Ohio 43210, USA.
Grainger A
Fischer B
Baiocchi RA
Carrodeguas L
Roychowdhury S
Chen L
Banks AL
Davis T
Young D
Kelbick N
Stephens J
Byrd JC
Grever MR
Caligiuri MA
Porcu P
Pokaż więcej
Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2004 Sep 15; Vol. 10 (18 Pt 1), pp. 6101-10.
Typ publikacji :
Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Antibodies, Monoclonal/*administration & dosage
Combined Modality Therapy/*methods
Immunotherapy/*methods
Interleukin-2/*administration & dosage
Lymphoma, B-Cell/*therapy
Lymphoma, Non-Hodgkin/*therapy
Adult ; Aged ; Aged, 80 and over ; Animals ; Antibodies, Monoclonal, Murine-Derived ; Antineoplastic Agents/administration & dosage ; Female ; Humans ; Interleukin-2/metabolism ; Killer Cells, Natural/immunology ; Leukocytes/immunology ; Leukocytes, Mononuclear/metabolism ; Lymphoma, B-Cell/immunology ; Lymphoma, Non-Hodgkin/immunology ; Male ; Mice ; Mice, SCID ; Middle Aged ; Rituximab ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia.
Autorzy :
Gore SD; The Johns Hopkins Oncology Center, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA. />Weng LJ
Figg WD
Zhai S
Donehower RC
Dover G
Grever MR
Griffin C
Grochow LB
Hawkins A
Burks K
Zabelena Y
Miller CB
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2002 Apr; Vol. 8 (4), pp. 963-70.
Typ publikacji :
Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Leukemia, Myeloid/*drug therapy
Myelodysplastic Syndromes/*drug therapy
Phenylbutyrates/*therapeutic use
Acute Disease ; Aged ; Apoptosis/drug effects ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/immunology ; Cell Cycle/drug effects ; Colony-Forming Units Assay ; Diarrhea/chemically induced ; Drug Administration Schedule ; Female ; Fetal Hemoglobin/drug effects ; Fetal Hemoglobin/metabolism ; Fever/chemically induced ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Nausea/chemically induced ; Phenylbutyrates/adverse effects ; Phenylbutyrates/pharmacokinetics ; Time Factors ; Treatment Outcome ; Vomiting/chemically induced
Czasopismo naukowe
    Wyświetlanie 1-12 z 12

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