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Wyszukujesz frazę ""Griffiths, Gillian"" wg kryterium: Autor


Tytuł :
Teasing out function from morphology: Similarities between primary cilia and immune synapses.
Autorzy :
Douanne T; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, England, UK.
Stinchcombe JC; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, England, UK.
Griffiths GM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, England, UK.
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Źródło :
The Journal of cell biology [J Cell Biol] 2021 Jun 07; Vol. 220 (6). Date of Electronic Publication: 2021 May 06.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Signal strength controls the rate of polarization within CTLs during killing.
Autorzy :
Frazer GL; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge, UK.
Gawden-Bone CM; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge, UK.
Dieckmann NMG; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge, UK.
Asano Y; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge, UK.
Griffiths GM; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge, UK.
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Źródło :
The Journal of cell biology [J Cell Biol] 2021 Oct 04; Vol. 220 (10). Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Cytoskeletal control of the secretory immune synapse.
Autorzy :
Douanne T; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY UK.
Griffiths GM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY UK. Electronic address: .
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Źródło :
Current opinion in cell biology [Curr Opin Cell Biol] 2021 Mar 09; Vol. 71, pp. 87-94. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement.
Autorzy :
Ohishi Y; Laboratory of Membrane Trafficking Mechanisms, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Ammann S; Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Ziaee V; Department of Pediatrics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.; Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Strege K; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Groß M; Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
Amos CV; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Shahrooei M; Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Ashournia P; Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Razaghian A; Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Ehl S; Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
Fukuda M; Laboratory of Membrane Trafficking Mechanisms, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Parvaneh N; Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.; Research Center for Immunodeficiencies, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Dec 10; Vol. 11, pp. 612977. Date of Electronic Publication: 2020 Dec 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Albinism/*genetics
Lymphohistiocytosis, Hemophagocytic/*genetics
Piebaldism/*genetics
Primary Immunodeficiency Diseases/*genetics
rab27 GTP-Binding Proteins/*genetics
Adaptor Proteins, Signal Transducing/genetics ; Adolescent ; Animals ; Binding Sites/genetics ; COS Cells ; Cell Line ; Child ; Child, Preschool ; Chlorocebus aethiops ; Female ; Humans ; Infant ; Infant, Newborn ; Leukocytes, Mononuclear/metabolism ; Male ; Membrane Proteins/genetics ; Mutation, Missense/genetics ; rab GTP-Binding Proteins/genetics
SCR Disease Name :
Griscelli syndrome type 2
Czasopismo naukowe
Tytuł :
Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling.
Autorzy :
Ma CY; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Marioni JC; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.; EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, United Kingdom.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom.
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Richard AC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
ELife [Elife] 2020 May 15; Vol. 9. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*drug effects
Lymphocyte Activation/*drug effects
Ovalbumin/*pharmacology
Receptors, Antigen, T-Cell/*agonists
Signal Transduction/*drug effects
Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cells, Cultured ; Female ; Flow Cytometry ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism ; Kinetics ; Ligands ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Nuclear Receptor Subfamily 4, Group A, Member 1/genetics ; Nuclear Receptor Subfamily 4, Group A, Member 1/metabolism ; Peptide Fragments/pharmacology ; Phosphorylation ; Receptors, Antigen, T-Cell/metabolism ; Ribosomal Protein S6/metabolism ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy.
Autorzy :
Huhn O; Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, CB2 0SW, UK.; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK.; AstraZeneca, Oncology R&D, Granta Park, Cambridge, CB21 6GH, UK.; Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
Ivarsson MA; Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Gardner L; Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
Hollinshead M; Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
Stinchcombe JC; Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK.
Chen P; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Shreeve N; Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, CB2 0SW, UK.; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK.
Chazara O; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK.; Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.; Centre for Genomics Research, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, CB4 0WG, UK.
Farrell LE; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK.; Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
Theorell J; Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
Ghadially H; AstraZeneca, Oncology R&D, Granta Park, Cambridge, CB21 6GH, UK.
Parham P; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Griffiths G; Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK.
Horowitz A; Precision Immunology Institute, Tisch Cancer Institute Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.
Moffett A; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK.; Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
Sharkey AM; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK. .; Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK. .
Colucci F; Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, CB2 0SW, UK. .; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Jan 20; Vol. 11 (1), pp. 381. Date of Electronic Publication: 2020 Jan 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Decidua/*cytology
Killer Cells, Natural/*immunology
Lymphocyte Subsets/*immunology
Placentation/*immunology
Animals ; Cell Communication/immunology ; Chemokines, C/immunology ; Chemokines, C/metabolism ; Decidua/growth & development ; Decidua/immunology ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Female ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class I/metabolism ; Humans ; K562 Cells ; Lymphocyte Activation ; Mice ; Pregnancy ; Receptors, KIR/immunology ; Receptors, KIR/metabolism ; Trophoblasts/immunology ; Trophoblasts/metabolism
Czasopismo naukowe
Tytuł :
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.
Autorzy :
Abeler-Dörner L; Department of Immunobiology, King's College London, London, UK.
Laing AG; Department of Immunobiology, King's College London, London, UK.; The Francis Crick Institute, London, UK.
Lorenc A; Department of Immunobiology, King's College London, London, UK.; The Francis Crick Institute, London, UK.
Ushakov DS; Department of Immunobiology, King's College London, London, UK.; The Francis Crick Institute, London, UK.
Clare S; Wellcome Sanger Institute, Hinxton, UK.
Speak AO; Wellcome Sanger Institute, Hinxton, UK.
Duque-Correa MA; Wellcome Sanger Institute, Hinxton, UK.
White JK; Wellcome Sanger Institute, Hinxton, UK.
Ramirez-Solis R; Wellcome Sanger Institute, Hinxton, UK.
Saran N; Department of Immunobiology, King's College London, London, UK.
Bull KR; MRC Human Immunology Unit, University of Oxford, Oxford, UK.
Morón B; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Iwasaki J; National Heart and Lung Institute, Imperial College London, London, UK.
Barton PR; Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK.
Caetano S; Department of Immunobiology, King's College London, London, UK.; Wellcome Sanger Institute, Hinxton, UK.
Hng KI; Department of Immunobiology, King's College London, London, UK.
Cambridge E; Wellcome Sanger Institute, Hinxton, UK.
Forman S; Lydia Becker Institute of Immunology and Inflammation, Wellcome Trust Centre for Cell Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Crockford TL; MRC Human Immunology Unit, University of Oxford, Oxford, UK.
Griffiths M; Wellcome Sanger Institute, Hinxton, UK.
Kane L; Wellcome Sanger Institute, Hinxton, UK.
Harcourt K; Wellcome Sanger Institute, Hinxton, UK.
Brandt C; Wellcome Sanger Institute, Hinxton, UK.
Notley G; Wellcome Sanger Institute, Hinxton, UK.
Babalola KO; European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK.
Warren J; European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK.
Mason JC; European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK.
Meeniga A; European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK.
Karp NA; Data Sciences & Quantitative Biology, Discovery Sciences, R&D Biopharmaceuticals, AstraZeneca, Cambridge, UK.
Melvin D; Wellcome Sanger Institute, Hinxton, UK.
Cawthorne E; MRC Human Immunology Unit, University of Oxford, Oxford, UK.
Weinrick B; Department of Microbiology and Immunology, Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
Rahim A; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.
Drissler S; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.
Meskas J; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.
Yue A; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.
Lux M; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.
Song-Zhao GX; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Chan A; Department of Immunobiology, King's College London, London, UK.
Ballesteros Reviriego C; Wellcome Sanger Institute, Hinxton, UK.
Abeler J; Department of Economics, University of Oxford, Oxford, UK.
Wilson H; Wellcome Sanger Institute, Hinxton, UK.
Przemska-Kosicka A; Department of Immunobiology, King's College London, London, UK.
Edmans M; MRC Human Immunology Unit, University of Oxford, Oxford, UK.
Strevens N; Wellcome Sanger Institute, Hinxton, UK.
Pasztorek M; Department of Immunobiology, King's College London, London, UK.; Department of Biomedical Science, University of Applied Sciences FH Campus Wien, Vienna, Austria.
Meehan TF; European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK.
Powrie F; The Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Brinkman R; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.; Department of Bioinformatics, University of British Columbia, Vancouver, BC, Canada.
Dougan G; Wellcome Sanger Institute, Hinxton, UK.
Jacobs W Jr; Department of Microbiology and Immunology, Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
Lloyd CM; National Heart and Lung Institute, Imperial College London, London, UK.
Cornall RJ; MRC Human Immunology Unit, University of Oxford, Oxford, UK.
Maloy KJ; Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK.
Grencis RK; Lydia Becker Institute of Immunology and Inflammation, Wellcome Trust Centre for Cell Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Griffiths GM; Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK.
Adams DJ; Wellcome Sanger Institute, Hinxton, UK.
Hayday AC; Department of Immunobiology, King's College London, London, UK. .; The Francis Crick Institute, London, UK. .
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Źródło :
Nature immunology [Nat Immunol] 2020 Jan; Vol. 21 (1), pp. 86-100. Date of Electronic Publication: 2019 Dec 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Enterobacteriaceae Infections/*immunology
Genetic Variation/*genetics
High-Throughput Screening Assays/*methods
Immunophenotyping/*methods
Salmonella Infections/*immunology
Animals ; Citrobacter/immunology ; Enterobacteriaceae Infections/microbiology ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Animal ; Salmonella/immunology ; Salmonella Infections/microbiology
Czasopismo naukowe
Tytuł :
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity.
Autorzy :
Randzavola LO; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Strege K; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Juzans M; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Asano Y; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Stinchcombe JC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Gawden-Bone CM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Seaman MN; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Kuijpers TW; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Medical Center Amsterdam University, Amsterdam, Netherlands.
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2019 Dec 02; Vol. 129 (12), pp. 5600-5614.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytotoxicity, Immunologic*
Actin-Related Protein 2-3 Complex/*physiology
T-Lymphocytes, Cytotoxic/*immunology
Actin-Related Protein 2-3 Complex/analysis ; Actins/analysis ; CD8 Antigens/analysis ; Cell Polarity ; Glucose Transporter Type 1/analysis ; HEK293 Cells ; Humans ; Immunological Synapses/physiology ; Lymphocyte Activation ; Receptors, Antigen, T-Cell, alpha-beta/analysis
Czasopismo naukowe
Tytuł :
Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse.
Autorzy :
Gawden-Bone CM; Cambridge Institute of Medical Research, University of Cambridge, Cambridge, United Kingdom.
Griffiths GM; Cambridge Institute of Medical Research, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
Frontiers in immunology [Front Immunol] 2019 Apr 11; Vol. 10, pp. 700. Date of Electronic Publication: 2019 Apr 11 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cytoplasmic Granules/*metabolism
Immunological Synapses/*metabolism
Phospholipids/*metabolism
Actins/immunology ; Actins/metabolism ; Cilia/immunology ; Cilia/metabolism ; Cytoplasmic Granules/immunology ; Cytoskeleton/immunology ; Cytoskeleton/metabolism ; Humans ; Immunological Synapses/immunology ; Metabolic Networks and Pathways ; Phospholipids/immunology ; Signal Transduction ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism
Czasopismo naukowe
Tytuł :
The Influence of External Focus Instruction Characteristics on Children's Motor Performance.
Autorzy :
Marchant DC; a Edge Hill University.
Griffiths G; a Edge Hill University.
Partridge JA; b Southern Illinois University.
Belsley L; b Southern Illinois University.
Porter JM; b Southern Illinois University.
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Źródło :
Research quarterly for exercise and sport [Res Q Exerc Sport] 2018 Dec; Vol. 89 (4), pp. 418-428. Date of Electronic Publication: 2018 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Athletic Performance/*physiology
Athletic Performance/*psychology
Attention/*physiology
Motor Skills/*physiology
Child ; Female ; Humans ; Male ; Motivation ; Movement ; Plyometric Exercise ; Task Performance and Analysis
Czasopismo naukowe
Tytuł :
PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes.
Autorzy :
Gawden-Bone CM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Frazer GL; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Richard AC; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK; Cancer Research UK Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK.
Ma CY; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Strege K; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Griffiths GM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK. Electronic address: .
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Źródło :
Immunity [Immunity] 2018 Sep 18; Vol. 49 (3), pp. 427-437.e4. Date of Electronic Publication: 2018 Sep 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actins/*metabolism
Cell Membrane/*metabolism
Cytoplasmic Granules/*metabolism
Immunological Synapses/*metabolism
Phosphatidylinositols/*metabolism
Phosphotransferases (Alcohol Group Acceptor)/*metabolism
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Cell Degranulation ; Cell Line ; Cytotoxicity, Immunologic ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
T cell cytolytic capacity is independent of initial stimulation strength.
Autorzy :
Richard AC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Lun ATL; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Lau WWY; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; Department of Haematology, Wellcome - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Göttgens B; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; Department of Haematology, Wellcome - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Marioni JC; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. .; European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Cambridge, UK. .; Wellcome Sanger Institute, Cambridge, UK. .
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. .
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Źródło :
Nature immunology [Nat Immunol] 2018 Aug; Vol. 19 (8), pp. 849-858. Date of Electronic Publication: 2018 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytotoxicity, Immunologic*
CD8-Positive T-Lymphocytes/*physiology
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
Animals ; Cell Line ; Genome ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; RNA/genetics ; Signal Transduction ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
An early history of T cell-mediated cytotoxicity.
Autorzy :
Golstein P; Centre d'Immunologie de Marseille-Luminy, Aix Marseille University, Inserm, CNRS, Marseille, France. .
Griffiths GM; Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK. .
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Źródło :
Nature reviews. Immunology [Nat Rev Immunol] 2018 Aug; Vol. 18 (8), pp. 527-535.
Typ publikacji :
Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cytotoxicity, Immunologic*
Immunity, Cellular*
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Fas Ligand Protein/immunology ; Granzymes/immunology ; History, 20th Century ; History, 21st Century ; Humans ; Immunotherapy/history ; Immunotherapy/trends ; Isoantigens/immunology ; Models, Immunological ; Perforin/immunology ; Receptors, Antigen, T-Cell/history ; Receptors, Antigen, T-Cell/immunology ; Signal Transduction/immunology ; fas Receptor/immunology
Czasopismo naukowe
Tytuł :
Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse.
Autorzy :
Lee J; CIMR, Department of Medicine, Cambridge University, Cambridge, UK.; Immunoregulation Section, Autoimmunity Branch, National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Dieckmann NMG; CIMR, Department of Medicine, Cambridge University, Cambridge, UK.
Edgar JR; CIMR, Department of Medicine, Cambridge University, Cambridge, UK.
Griffiths GM; CIMR, Department of Medicine, Cambridge University, Cambridge, UK.
Siegel RM; Immunoregulation Section, Autoimmunity Branch, National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
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Źródło :
Immunity, inflammation and disease [Immun Inflamm Dis] 2018 Jun; Vol. 6 (2), pp. 312-321. Date of Electronic Publication: 2018 Apr 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytoplasmic Granules/*metabolism
Fas Ligand Protein/*metabolism
Immunological Synapses/*metabolism
Killer Cells, Natural/*metabolism
B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Culture Techniques ; Cell Line ; Cytoplasmic Granules/immunology ; Cytoplasmic Granules/ultrastructure ; Fas Ligand Protein/immunology ; Fas Ligand Protein/ultrastructure ; Granzymes/metabolism ; HLA Antigens/metabolism ; Humans ; Immunological Synapses/immunology ; Immunological Synapses/ultrastructure ; Killer Cells, Natural/cytology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/ultrastructure ; Microscopy, Electron ; Perforin/metabolism ; Tetraspanin 30/immunology ; Tetraspanin 30/metabolism
Czasopismo naukowe
Tytuł :
Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.
Autorzy :
Ritter AT; National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD 20892.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Kapnick SM; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Murugesan S; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Schwartzberg PL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; .
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom; .
Lippincott-Schwartz J; National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD 20892; .; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Aug 08; Vol. 114 (32), pp. E6585-E6594. Date of Electronic Publication: 2017 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Actins/*immunology
CD8-Positive T-Lymphocytes/*immunology
Immunological Synapses/*immunology
Phosphatidylinositol 4,5-Diphosphate/*immunology
Secretory Vesicles/*immunology
rab27 GTP-Binding Proteins/*immunology
Actins/genetics ; Animals ; CD8-Positive T-Lymphocytes/cytology ; Immunological Synapses/genetics ; Mice ; Mice, Transgenic ; Phosphatidylinositol 4,5-Diphosphate/genetics ; Secretory Vesicles/genetics ; rab27 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8 CTLs.
Autorzy :
Kapnick SM; National Human Genome Research Institute, Bethesda, MD 20892; and.
Stinchcombe JC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Schwartzberg PL; National Human Genome Research Institute, Bethesda, MD 20892; and .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2017 Apr 01; Vol. 198 (7), pp. 2699-2711. Date of Electronic Publication: 2017 Feb 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Cytotoxicity, Immunologic/*immunology
Protein-Tyrosine Kinases/*immunology
Animals ; Cell Degranulation/immunology ; Flow Cytometry ; Fluorescent Antibody Technique ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microscopy, Confocal ; Microscopy, Electron, Transmission
Czasopismo naukowe
Tytuł :
Imaging the Effector CD8 Synapse.
Autorzy :
Frazer GL; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.
Asano Y; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1584, pp. 473-486.
Typ publikacji :
Journal Article
MeSH Terms :
Imaging, Three-Dimensional*
CD8-Positive T-Lymphocytes/*immunology
Immunological Synapses/*immunology
Animals ; CD8-Positive T-Lymphocytes/cytology ; Humans ; Microscopy, Confocal/methods
Czasopismo naukowe
Tytuł :
Secretion from Myeloid Cells: Secretory Lysosomes.
Autorzy :
Griffiths GM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom.
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Źródło :
Microbiology spectrum [Microbiol Spectr] 2016 Aug; Vol. 4 (4).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Lysosomes/*metabolism
Myeloid Cells/*metabolism
Proteins/*metabolism
Secretory Vesicles/*metabolism
Animals ; Humans
Czasopismo naukowe
Tytuł :
The cytotoxic T lymphocyte immune synapse at a glance.
Autorzy :
Dieckmann NM; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
Frazer GL; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
Asano Y; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
Stinchcombe JC; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
Griffiths GM; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK .
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Źródło :
Journal of cell science [J Cell Sci] 2016 Aug 01; Vol. 129 (15), pp. 2881-6.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunological Synapses/*metabolism
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Cell Membrane/metabolism ; Cilia/metabolism ; Humans ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction
Czasopismo naukowe

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