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Wyszukujesz frazę ""Griffiths, Gillian"" wg kryterium: Autor


Tytuł :
Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse.
Autorzy :
Gawden-Bone CM; Cambridge Institute of Medical Research, University of Cambridge, Cambridge, United Kingdom.
Griffiths GM; Cambridge Institute of Medical Research, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
Frontiers in immunology [Front Immunol] 2019 Apr 11; Vol. 10, pp. 700. Date of Electronic Publication: 2019 Apr 11 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cytoplasmic Granules/*metabolism
Immunological Synapses/*metabolism
Phospholipids/*metabolism
Actins/immunology ; Actins/metabolism ; Cilia/immunology ; Cilia/metabolism ; Cytoplasmic Granules/immunology ; Cytoskeleton/immunology ; Cytoskeleton/metabolism ; Humans ; Immunological Synapses/immunology ; Metabolic Networks and Pathways ; Phospholipids/immunology ; Signal Transduction ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism
Czasopismo naukowe
Tytuł :
PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes.
Autorzy :
Gawden-Bone CM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Frazer GL; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Richard AC; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK; Cancer Research UK Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK.
Ma CY; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Strege K; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Griffiths GM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK. Electronic address: .
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Źródło :
Immunity [Immunity] 2018 Sep 18; Vol. 49 (3), pp. 427-437.e4. Date of Electronic Publication: 2018 Sep 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actins/*metabolism
Cell Membrane/*metabolism
Cytoplasmic Granules/*metabolism
Immunological Synapses/*metabolism
Phosphatidylinositols/*metabolism
Phosphotransferases (Alcohol Group Acceptor)/*metabolism
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Cell Degranulation ; Cell Line ; Cytotoxicity, Immunologic ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse.
Autorzy :
Lee J; CIMR, Department of Medicine, Cambridge University, Cambridge, UK.; Immunoregulation Section, Autoimmunity Branch, National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Dieckmann NMG; CIMR, Department of Medicine, Cambridge University, Cambridge, UK.
Edgar JR; CIMR, Department of Medicine, Cambridge University, Cambridge, UK.
Griffiths GM; CIMR, Department of Medicine, Cambridge University, Cambridge, UK.
Siegel RM; Immunoregulation Section, Autoimmunity Branch, National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
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Źródło :
Immunity, inflammation and disease [Immun Inflamm Dis] 2018 Jun; Vol. 6 (2), pp. 312-321. Date of Electronic Publication: 2018 Apr 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytoplasmic Granules/*metabolism
Fas Ligand Protein/*metabolism
Immunological Synapses/*metabolism
Killer Cells, Natural/*metabolism
B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Culture Techniques ; Cell Line ; Cytoplasmic Granules/immunology ; Cytoplasmic Granules/ultrastructure ; Fas Ligand Protein/immunology ; Fas Ligand Protein/ultrastructure ; Granzymes/metabolism ; HLA Antigens/metabolism ; Humans ; Immunological Synapses/immunology ; Immunological Synapses/ultrastructure ; Killer Cells, Natural/cytology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/ultrastructure ; Microscopy, Electron ; Perforin/metabolism ; Tetraspanin 30/immunology ; Tetraspanin 30/metabolism
Czasopismo naukowe
Tytuł :
Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.
Autorzy :
Ritter AT; National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD 20892.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Kapnick SM; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Murugesan S; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Schwartzberg PL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; .
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom; .
Lippincott-Schwartz J; National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD 20892; .; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Aug 08; Vol. 114 (32), pp. E6585-E6594. Date of Electronic Publication: 2017 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Actins/*immunology
CD8-Positive T-Lymphocytes/*immunology
Immunological Synapses/*immunology
Phosphatidylinositol 4,5-Diphosphate/*immunology
Secretory Vesicles/*immunology
rab27 GTP-Binding Proteins/*immunology
Actins/genetics ; Animals ; CD8-Positive T-Lymphocytes/cytology ; Immunological Synapses/genetics ; Mice ; Mice, Transgenic ; Phosphatidylinositol 4,5-Diphosphate/genetics ; Secretory Vesicles/genetics ; rab27 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Imaging the Effector CD8 Synapse.
Autorzy :
Frazer GL; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.
Asano Y; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1584, pp. 473-486.
Typ publikacji :
Journal Article
MeSH Terms :
Imaging, Three-Dimensional*
CD8-Positive T-Lymphocytes/*immunology
Immunological Synapses/*immunology
Animals ; CD8-Positive T-Lymphocytes/cytology ; Humans ; Microscopy, Confocal/methods
Czasopismo naukowe
Tytuł :
The cytotoxic T lymphocyte immune synapse at a glance.
Autorzy :
Dieckmann NM; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
Frazer GL; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
Asano Y; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
Stinchcombe JC; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
Griffiths GM; Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK .
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Źródło :
Journal of cell science [J Cell Sci] 2016 Aug 01; Vol. 129 (15), pp. 2881-6.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunological Synapses/*metabolism
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Cell Membrane/metabolism ; Cilia/metabolism ; Humans ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Origins of the cytolytic synapse.
Autorzy :
de la Roche M; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.; CRUK-Cambridge Research Institute, Cambridge CB2 0RE, UK.
Asano Y; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.
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Źródło :
Nature reviews. Immunology [Nat Rev Immunol] 2016 Jul; Vol. 16 (7), pp. 421-32. Date of Electronic Publication: 2016 Jun 06.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytotoxicity, Immunologic/*immunology
Immunological Synapses/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Humans ; Immunological Synapses/ultrastructure ; T-Lymphocytes, Cytotoxic/ultrastructure
Czasopismo naukowe
Tytuł :
Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis.
Autorzy :
Stinchcombe JC; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
Randzavola LO; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
Angus KL; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
Mantell JM; Wolfson Bioimaging Facility, University of Bristol, Medical Sciences, Bristol BS8 1TD, UK.
Verkade P; Wolfson Bioimaging Facility, University of Bristol, Medical Sciences, Bristol BS8 1TD, UK.
Griffiths GM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK. Electronic address: .
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Źródło :
Current biology : CB [Curr Biol] 2015 Dec 21; Vol. 25 (24), pp. 3239-44. Date of Electronic Publication: 2015 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Centrioles/*physiology
Cilia/*physiology
Immunological Synapses/*physiology
T-Lymphocytes, Cytotoxic/*physiology
Animals ; Cells, Cultured ; Mice, Inbred C57BL ; Microscopy, Electron, Transmission ; T-Lymphocytes, Cytotoxic/ultrastructure
Czasopismo naukowe
Tytuł :
Actin depletion initiates events leading to granule secretion at the immunological synapse.
Autorzy :
Ritter AT; Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK; National Institute of Child Health and Disease, NIH, Bethesda, MD 20892, USA.
Asano Y; Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
Stinchcombe JC; Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
Dieckmann NM; Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
Chen BC; Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.
Gawden-Bone C; Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
van Engelenburg S; National Institute of Child Health and Disease, NIH, Bethesda, MD 20892, USA.
Legant W; Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.
Gao L; Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.
Davidson MW; National High Magnetic Field Laboratory and Department of Biological Science, Florida State University, Tallahassee, FL 32304, USA.
Betzig E; Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.
Lippincott-Schwartz J; National Institute of Child Health and Disease, NIH, Bethesda, MD 20892, USA. Electronic address: .
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK. Electronic address: .
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Źródło :
Immunity [Immunity] 2015 May 19; Vol. 42 (5), pp. 864-76.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actins/*metabolism
Cytoplasmic Granules/*metabolism
Immunological Synapses/*metabolism
T-Lymphocytes, Cytotoxic/*cytology
Cell Membrane/chemistry ; Cells, Cultured ; Cytoplasmic Granules/chemistry ; Fluorescent Antibody Technique ; Humans ; Models, Immunological ; Phospholipids/metabolism ; T-Lymphocytes, Cytotoxic/metabolism
Czasopismo naukowe
Tytuł :
Communication, the centrosome and the immunological synapse.
Autorzy :
Stinchcombe JC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, UK.
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, UK .
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Źródło :
Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2014 Sep 05; Vol. 369 (1650).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biological Evolution*
Models, Immunological*
Cell Communication/*physiology
Centrosome/*physiology
Cilia/*physiology
Immune System/*physiology
Immunological Synapses/*physiology
Animals ; Cell Polarity
Czasopismo naukowe
Tytuł :
Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.
Autorzy :
Jenkins MR; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Stinchcombe JC
Au-Yeung BB
Asano Y
Ritter AT
Weiss A
Griffiths GM
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Źródło :
ELife [Elife] 2014 Mar 04; Vol. 3, pp. e01310. Date of Electronic Publication: 2014 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigen-Presenting Cells/*physiology
Immunological Synapses/*metabolism
T-Lymphocytes, Cytotoxic/*physiology
ZAP-70 Protein-Tyrosine Kinase/*metabolism
Actins/metabolism ; Animals ; Cell Membrane/metabolism ; Gene Knockdown Techniques ; Mice, Inbred BALB C ; T-Lymphocytes, Cytotoxic/enzymology ; ZAP-70 Protein-Tyrosine Kinase/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
The role of the cytoskeleton at the immunological synapse.
Autorzy :
Ritter AT; Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Cambridge, UK.
Angus KL
Griffiths GM
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Źródło :
Immunological reviews [Immunol Rev] 2013 Nov; Vol. 256 (1), pp. 107-17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cytoskeleton/*physiology
Immunological Synapses/*physiology
Actins/metabolism ; Animals ; Calcium Signaling ; Cell Movement ; Centrosome/physiology ; Dyneins/metabolism ; Humans ; Lymphocyte Activation ; Microtubules/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
Cell polarisation and the immunological synapse.
Autorzy :
Angus KL; Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, CB2 0XY, England, UK.
Griffiths GM
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Źródło :
Current opinion in cell biology [Curr Opin Cell Biol] 2013 Feb; Vol. 25 (1), pp. 85-91. Date of Electronic Publication: 2012 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cell Polarity*
Immunological Synapses/*metabolism
Actins/metabolism ; Animals ; Cell Membrane/metabolism ; Centrosome/metabolism ; Cilia/immunology ; Cilia/metabolism ; Exocytosis/immunology ; Killer Cells, Natural/cytology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Secretory Vesicles/metabolism ; T-Lymphocytes, Cytotoxic/cytology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism
Czasopismo naukowe
Tytuł :
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.
Autorzy :
Zhao F; Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cannons JL
Dutta M
Griffiths GM
Schwartzberg PL
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Źródło :
Immunity [Immunity] 2012 Jun 29; Vol. 36 (6), pp. 1003-16. Date of Electronic Publication: 2012 Jun 07.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD/*immunology
Antigens, Ly/*immunology
Immunological Synapses/*immunology
Intracellular Signaling Peptides and Proteins/*immunology
Receptors, Immunologic/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Actins/analysis ; Animals ; B-Lymphocytes ; Cell Adhesion ; Cell Line, Tumor ; Centrosome/ultrastructure ; Cytoskeleton/ultrastructure ; Cytotoxicity, Immunologic ; Fibrosarcoma/pathology ; Inositol Polyphosphate 5-Phosphatases ; Intracellular Signaling Peptides and Proteins/deficiency ; Intracellular Signaling Peptides and Proteins/genetics ; Lymphoma, T-Cell/pathology ; Mice ; Phosphoric Monoester Hydrolases/antagonists & inhibitors ; Phosphoric Monoester Hydrolases/physiology ; Phosphorylation ; Protein Processing, Post-Translational ; Signaling Lymphocytic Activation Molecule Associated Protein ; Signaling Lymphocytic Activation Molecule Family ; T-Lymphocytes ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł :
Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems.
Autorzy :
Stinchcombe JC; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Salio M
Cerundolo V
Pende D
Arico M
Griffiths GM
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Źródło :
BMC biology [BMC Biol] 2011 Jun 28; Vol. 9, pp. 45. Date of Electronic Publication: 2011 Jun 28.
Typ publikacji :
Journal Article
MeSH Terms :
Centrioles/*metabolism
Centrioles/*ultrastructure
Immune System/*metabolism
Immunological Synapses/*metabolism
Immunological Synapses/*ultrastructure
T-Lymphocytes, Cytotoxic/*metabolism
T-Lymphocytes, Cytotoxic/*ultrastructure
Adaptive Immunity/physiology ; Cells, Cultured ; Humans ; Immune System/ultrastructure ; Microscopy, Electron, Transmission
Czasopismo naukowe
Tytuł :
The synapse and cytolytic machinery of cytotoxic T cells.
Autorzy :
Jenkins MR; Cambridge Institute for Medical Research, Addenbrooke's, Cambridge, United Kingdom.
Griffiths GM
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Źródło :
Current opinion in immunology [Curr Opin Immunol] 2010 Jun; Vol. 22 (3), pp. 308-13. Date of Electronic Publication: 2010 Mar 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cytotoxicity, Immunologic*
Cytoskeleton/*metabolism
Immunological Synapses/*immunology
Secretory Vesicles/*metabolism
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Mice ; Microscopy, Confocal ; Microscopy, Fluorescence ; Signal Transduction ; T-Lymphocytes, Cytotoxic/metabolism
Czasopismo naukowe
Tytuł :
The immunological synapse: a focal point for endocytosis and exocytosis.
Autorzy :
Griffiths GM; Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, England, UK. />Tsun A
Stinchcombe JC
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Źródło :
The Journal of cell biology [J Cell Biol] 2010 May 03; Vol. 189 (3), pp. 399-406.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Endocytosis/*physiology
Exocytosis/*physiology
Immunological Synapses/*physiology
Animals ; Cell Membrane/metabolism ; Cilia/metabolism ; Humans ; Models, Biological ; Presynaptic Terminals/physiology ; Synapses/metabolism
Czasopismo naukowe

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