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Wyświetlanie 1-19 z 19
Tytuł :
Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis.
Autorzy :
Radzisheuskaya A; Cell Biology Program and Center for Epigenetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N 2200, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (Danstem), University of Copenhagen, Copenhagen N 2200, Denmark.
Shliaha PV; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Odense 5230, Denmark; Microchemistry and Proteomics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Grinev VV; Department of Genetics, Faculty of Biology, Belarusian State University, Minsk 220030, Belarus.
Shlyueva D; Cell Biology Program and Center for Epigenetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N 2200, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (Danstem), University of Copenhagen, Copenhagen N 2200, Denmark.
Damhofer H; Cell Biology Program and Center for Epigenetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N 2200, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (Danstem), University of Copenhagen, Copenhagen N 2200, Denmark.
Koche R; Center for Epigenetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Gorshkov V; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Odense 5230, Denmark.
Kovalchuk S; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Odense 5230, Denmark; Laboratory of Bioinformatic Methods for Combinatorial Chemistry and Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russian Federation.
Zhan Y; Center for Epigenetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Rodriguez KL; EpiCypher Inc., Durham, NC 27709, USA.
Johnstone AL; EpiCypher Inc., Durham, NC 27709, USA.
Keogh MC; EpiCypher Inc., Durham, NC 27709, USA.
Hendrickson RC; Microchemistry and Proteomics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jensen ON; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Odense 5230, Denmark.
Helin K; Cell Biology Program and Center for Epigenetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N 2200, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (Danstem), University of Copenhagen, Copenhagen N 2200, Denmark. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Apr 15; Vol. 81 (8), pp. 1749-1765.e8. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Histone Acetyltransferases/*genetics
Homeostasis/*genetics
Transcription, Genetic/*genetics
Acetylation ; Animals ; Cell Line ; Cell Line, Tumor ; Cell Nucleus/genetics ; Cell Proliferation/genetics ; Chromatin/genetics ; HEK293 Cells ; HeLa Cells ; Histones/genetics ; Humans ; K562 Cells ; Lysine/genetics ; Male ; Mice ; Promoter Regions, Genetic/genetics ; THP-1 Cells
Czasopismo naukowe
Tytuł :
RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia.
Autorzy :
Grinev VV; Department of Genetics, Faculty of Biology, Belarusian State University, 220030, Minsk, Republic of Belarus. .
Barneh F; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands.
Ilyushonak IM; Department of Genetics, Faculty of Biology, Belarusian State University, 220030, Minsk, Republic of Belarus.
Nakjang S; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Smink J; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands.
van Oort A; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands.
Clough R; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Seyani M; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
McNeill H; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Reza M; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Martinez-Soria N; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Assi SA; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Ramanouskaya TV; Department of Genetics, Faculty of Biology, Belarusian State University, 220030, Minsk, Republic of Belarus.
Bonifer C; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Heidenreich O; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands. .; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. .; Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 22; Vol. 12 (1), pp. 520. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Gene Expression Regulation, Leukemic*
Core Binding Factor Alpha 2 Subunit/*genetics
Leukemia, Myeloid/*genetics
Oncogene Proteins, Fusion/*genetics
RUNX1 Translocation Partner 1 Protein/*genetics
Acute Disease ; Cell Line, Tumor ; Core Binding Factor Alpha 2 Subunit/metabolism ; Gene Expression Profiling/methods ; Humans ; Leukemia, Myeloid/pathology ; Models, Genetic ; Oncogene Proteins, Fusion/metabolism ; RNA Interference ; RNA Isoforms/genetics ; RNA Isoforms/metabolism ; RUNX1 Translocation Partner 1 Protein/metabolism ; Transcription Initiation Site
Czasopismo naukowe
Tytuł :
The determinants of alternative RNA splicing in human cells.
Autorzy :
Ramanouskaya TV; Belarusian State University, Minsk, Belarus. .
Grinev VV; Belarusian State University, Minsk, Belarus.
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Źródło :
Molecular genetics and genomics : MGG [Mol Genet Genomics] 2017 Dec; Vol. 292 (6), pp. 1175-1195. Date of Electronic Publication: 2017 Jul 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alternative Splicing*
Humans ; Nucleic Acid Conformation ; RNA/chemistry
Czasopismo naukowe
Tytuł :
Decoding of exon splicing patterns in the human RUNX1-RUNX1T1 fusion gene.
Autorzy :
Grinev VV; Department of Genetics, Faculty of Biology, Belarusian State University, Minsk, Belarus. Electronic address: .
Migas AA; Laboratory of the Genetic Biotechnology, Department of Research, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Kirsanava AD; Department of Genetics, Faculty of Biology, Belarusian State University, Minsk, Belarus.
Mishkova OA; Laboratory of the Genetic Biotechnology, Department of Research, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Siomava N; Department of Developmental Biology, University of Göttingen, Göttingen, Germany.
Ramanouskaya TV; Department of Genetics, Faculty of Biology, Belarusian State University, Minsk, Belarus.
Vaitsiankova AV; Department of Genetics, Faculty of Biology, Belarusian State University, Minsk, Belarus.
Ilyushonak IM; Department of Genetics, Faculty of Biology, Belarusian State University, Minsk, Belarus.
Nazarov PV; Genomics Research Unit, Luxembourg Institute of Health, Luxembourg.
Vallar L; Genomics Research Unit, Luxembourg Institute of Health, Luxembourg.
Aleinikova OV; Laboratory of the Genetic Biotechnology, Department of Research, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
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Źródło :
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2015 Nov; Vol. 68, pp. 48-58. Date of Electronic Publication: 2015 Aug 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Gene Expression Regulation, Leukemic*
Translocation, Genetic*
Core Binding Factor Alpha 2 Subunit/*genetics
Leukemia, Myeloid, Acute/*genetics
Oncogene Proteins, Fusion/*genetics
RNA, Messenger/*genetics
Cell Line, Tumor ; Chromosomes, Human, Pair 21 ; Chromosomes, Human, Pair 8 ; Computational Biology/methods ; Core Binding Factor Alpha 2 Subunit/metabolism ; Exons ; Half-Life ; Humans ; Introns ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Oncogene Proteins, Fusion/metabolism ; RNA Stability ; RNA, Messenger/metabolism ; RUNX1 Translocation Partner 1 Protein ; Signal Transduction ; Stochastic Processes
Czasopismo naukowe
Tytuł :
RUNX1T1/MTG8/ETO gene expression status in human t(8;21)(q22;q22)-positive acute myeloid leukemia cells.
Autorzy :
Migas AA; Laboratory of the Genetic Biotechnology, Department of Research, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Mishkova OA; Laboratory of the Genetic Biotechnology, Department of Research, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Ramanouskaya TV; Department of Genetics, Faculty of Biology, Belarusian State University, Minsk, Belarus.
Ilyushonak IM; Department of Genetics, Faculty of Biology, Belarusian State University, Minsk, Belarus.
Aleinikova OV; Laboratory of the Genetic Biotechnology, Department of Research, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Grinev VV; Department of Genetics, Faculty of Biology, Belarusian State University, Minsk, Belarus. Electronic address: .
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Źródło :
Leukemia research [Leuk Res] 2014 Sep; Vol. 38 (9), pp. 1102-10. Date of Electronic Publication: 2014 Jun 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Translocation, Genetic*
Chromosomes, Human, Pair 21/*genetics
Chromosomes, Human, Pair 8/*genetics
Leukemia, Myeloid, Acute/*genetics
Proto-Oncogene Proteins/*genetics
Transcription Factors/*genetics
Cell Transformation, Neoplastic/genetics ; Chromosome Mapping ; Gene Expression Regulation, Leukemic ; Gene Regulatory Networks ; HEK293 Cells ; Humans ; Leukemia, Myeloid, Acute/pathology ; Promoter Regions, Genetic ; RUNX1 Translocation Partner 1 Protein ; Sequence Analysis, DNA ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Multidimensional control of cell structural robustness.
Autorzy :
Grinev VV; Biology Faculty, Department of Genetics, Belarusian State University, 220030, Minsk, Belarus. />Ramanouskaya TV
Gloushen SV
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Źródło :
Cell biology international [Cell Biol Int] 2013 Oct; Vol. 37 (10), pp. 1023-37. Date of Electronic Publication: 2013 Jun 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cells/*cytology
Cells/*metabolism
Animals ; Humans ; Signal Transduction
Czasopismo naukowe
Tytuł :
[Mapping of the 3' end for artificial human microRNA].
Autorzy :
Grinev VV
Posrednik DV
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Źródło :
Genetika [Genetika] 2012 Jul; Vol. 48 (7), pp. 894-6.
Typ publikacji :
Journal Article
MeSH Terms :
Core Binding Factor Alpha 2 Subunit/*genetics
MicroRNAs/*chemical synthesis
MicroRNAs/*genetics
Oncogene Proteins, Fusion/*genetics
RNA, Antisense/*chemical synthesis
3' Untranslated Regions/genetics ; HEK293 Cells ; Humans ; MicroRNAs/biosynthesis ; RNA, Antisense/genetics ; RNA, Messenger/genetics ; RUNX1 Translocation Partner 1 Protein
Czasopismo naukowe
Tytuł :
[Highly efficient transfer and stable expression of two genes upon lentivirus transduction of mesenchymal stem cells from human bone marrow].
Autorzy :
Grinev VV
Severin IN
Posrednik DV
Kosmacheva SM
Potapnev MP
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Źródło :
Genetika [Genetika] 2012 Mar; Vol. 48 (3), pp. 389-400.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Marrow Cells*/cytology
Bone Marrow Cells*/metabolism
Genetic Vectors*
Mesenchymal Stem Cells*/cytology
Mesenchymal Stem Cells*/metabolism
Transduction, Genetic/*methods
Cell Differentiation ; Gene Expression ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; Humans ; Lentivirus/genetics ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Transgenes
Czasopismo naukowe
Tytuł :
[Structural and thermodynamic features of intergenic and intronic human primary microRNAs].
Autorzy :
Posrednik DV
Romanovskaia TV
Radishchevskaia AA
Khatskevich AA
Goncharevich AIu
Cherepovich VS
Grinev VV
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Źródło :
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2011 May-Jun; Vol. 45 (3), pp. 554-64.
Typ publikacji :
English Abstract; Journal Article
MeSH Terms :
Introns*
Nucleic Acid Conformation*
Thermodynamics*
DNA, Intergenic/*chemistry
MicroRNAs/*chemistry
Humans
Czasopismo naukowe
Tytuł :
Relationship between structure and antiproliferative, proapoptotic, and differentiation effects of flavonoids on chronic myeloid leukemia cells.
Autorzy :
Ramanouskaya TV; Department of Genetics, Faculty of Biology, Belarusian State University, Minsk 220030, Belarus. />Smolnykova VV
Grinev VV
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Źródło :
Anti-cancer drugs [Anticancer Drugs] 2009 Aug; Vol. 20 (7), pp. 573-83.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Cell Proliferation/*drug effects
Flavonoids/*pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/chemistry ; Apoptosis/drug effects ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Flavonoids/administration & dosage ; Flavonoids/chemistry ; Humans ; Inhibitory Concentration 50 ; K562 Cells ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/physiopathology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Cytotoxic effect of flavonoids on leukemia cells and normal cells of human blood.
Autorzy :
Romanouskaya TV; Belarussian State University, Minsk, Belarussia. />Grinev VV
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Źródło :
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2009 Jul; Vol. 148 (1), pp. 57-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Flavonoids/*pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*pathology
Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Humans ; K562 Cells
Czasopismo naukowe
Tytuł :
Viral vectors for stable transduction of human mesenchymal stem cells: systems based on adeno-associated viruses and lentiviruses.
Autorzy :
Shakhbazau AV; Institute of Genetics and Cytology, National Academy of Sciences of Belarus, Minsk, Belarussia. />Sevyaryn IN
Goncharova NV
Grinev VV
Kosmacheva SM
Potapnev MP
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Źródło :
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2008 Oct; Vol. 146 (4), pp. 531-3.
Typ publikacji :
Journal Article
MeSH Terms :
Dependovirus/*genetics
Genetic Vectors/*genetics
Lentivirus/*genetics
Mesenchymal Stem Cells/*virology
Transfection/*methods
Cell Line ; Humans
Czasopismo naukowe
Tytuł :
[Modulating effect of antileukemia drugs on the cellular susceptibility in chronic myeloid leukemia to cytotoxic lymphocytes].
Autorzy :
Cherepovich VS
Shakhlevich EV
Antonenko EV
Lotkova ES
Grinëv VV
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Źródło :
Voprosy onkologii [Vopr Onkol] 2006; Vol. 52 (4), pp. 417-20.
Typ publikacji :
English Abstract; Journal Article
MeSH Terms :
Leukocytes, Mononuclear*
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*therapy
Busulfan/pharmacology ; Cytarabine/pharmacology ; Humans ; Hydroxyurea/pharmacology ; K562 Cells ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy
Czasopismo naukowe
Tytuł :
Significance of serum immunoglobulin G for leukocytosis and prognosis in childhood B-lineage acute lymphoblastic leukemia.
Autorzy :
Potapnev MP; Belarussian Center for Pediatric Oncology and Hematology, Belarus. />Belevtsev MV
Bortkevich LG
Grinev VV
Martsev SP
Kravchuk ZI
Migal NV
Aleinikova OV
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2004 May; Vol. 42 (5), pp. 421-6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Burkitt Lymphoma/*diagnosis
Immunoglobulin G/*blood
Leukocytosis/*immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis
Adolescent ; Antibodies, Neoplasm/blood ; Burkitt Lymphoma/immunology ; Burkitt Lymphoma/pathology ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Humans ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Prognosis ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Different Mechanisms of Resistance to Lymphokine-activated Killer (LAK) Cells in Leukemic Cell Sublines Selected by Etoposide or by LAK Cells.
Autorzy :
Grinev VV; a Belarusian State University , F. Skoriny Avenue-4, 220050 Minsk , Belarus.
Grigorovich SA; b Hematology and Blood Transfusion Research Institute , 160 Dolginovski Trakt, 223059 Minsk , Belarus.
Shman TV; c Belarussian Center for Pediatric Oncology and Hematology, P.O Lesnoye-2, Minsk District , 223052 Belarus.
Sheleg SV; b Hematology and Blood Transfusion Research Institute , 160 Dolginovski Trakt, 223059 Minsk , Belarus.
Smolnikova VV; b Hematology and Blood Transfusion Research Institute , 160 Dolginovski Trakt, 223059 Minsk , Belarus.
Potapnev MP; c Belarussian Center for Pediatric Oncology and Hematology, P.O Lesnoye-2, Minsk District , 223052 Belarus.
Svirnovski AI; b Hematology and Blood Transfusion Research Institute , 160 Dolginovski Trakt, 223059 Minsk , Belarus.
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Źródło :
Hematology (Amsterdam, Netherlands) [Hematology] 2001; Vol. 6 (5), pp. 321-9.
Typ publikacji :
Journal Article
Czasopismo naukowe
    Wyświetlanie 1-19 z 19

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