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Wyszukujesz frazę ""Growth differentiation factor 15"" wg kryterium: Temat


Tytuł :
GDF15 as a biomarker of ageing.
Autorzy :
Liu H; Department of Clinical Laboratory, Wuhan University, Renmin Hospital, Wuhan 430060, Hubei Province, China.
Huang Y; Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China.
Lyu Y; Department of Cardiology, Wuhan University, Renmin Hospital, Wuhan 430060, Hubei Province, China.
Dai W; Department of Clinical Laboratory, Wuhan University, Renmin Hospital, Wuhan 430060, Hubei Province, China.
Tong Y; Department of Clinical Laboratory, Wuhan University, Renmin Hospital, Wuhan 430060, Hubei Province, China.
Li Y; Department of Clinical Laboratory, Wuhan University, Renmin Hospital, Wuhan 430060, Hubei Province, China. Electronic address: .
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Źródło :
Experimental gerontology [Exp Gerontol] 2021 Apr; Vol. 146, pp. 111228. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Growth Differentiation Factor 15*/genetics
Telomerase*/genetics
Telomerase*/metabolism
Aged ; Aged, 80 and over ; Aging ; Biomarkers ; Cross-Sectional Studies ; Humans ; Leukocytes, Mononuclear/metabolism ; Male ; Telomere/metabolism
Czasopismo naukowe
Tytuł :
ATF4-mediated GDF15 suppresses LPS-induced inflammation and MUC5AC in human nasal epithelial cells through the PI3K/Akt pathway.
Autorzy :
Li A; Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, PR China.
Zhao F; Department of Medical Imaging, Chang'an Hospital, Xi'an 710016, Shaanxi, PR China.
Zhao Y; Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, PR China.
Liu H; Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, PR China.
Wang Z; Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jun 15; Vol. 275, pp. 119356. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Activating Transcription Factor 4/*physiology
Growth Differentiation Factor 15/*physiology
Inflammation/*metabolism
Mucin 5AC/*metabolism
Nasal Mucosa/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Activating Transcription Factor 4/metabolism ; Cells, Cultured ; Chromatin Immunoprecipitation ; Cytokines/metabolism ; Cytokines/physiology ; Growth Differentiation Factor 15/metabolism ; Humans ; Inflammation/physiopathology ; Lipopolysaccharides/pharmacology ; Mucin 5AC/physiology ; Nasal Mucosa/physiopathology ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
X‑irradiation induces acute and early term inflammatory responses in atherosclerosis‑prone ApoE‑/‑ mice and in endothelial cells.
Autorzy :
Ramadan R; Radiobiology Unit, Belgian Nuclear Research Centre, 2400 Mol, Belgium.
Claessens M; Department of Basic and Applied Medical Sciences, Physiology Group, Ghent University, 9000 Ghent, Belgium.
Cocquyt E; Department of Basic and Applied Medical Sciences, Physiology Group, Ghent University, 9000 Ghent, Belgium.
Mysara M; Microbiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.
Decrock E; Department of Basic and Applied Medical Sciences, Physiology Group, Ghent University, 9000 Ghent, Belgium.
Baatout S; Radiobiology Unit, Belgian Nuclear Research Centre, 2400 Mol, Belgium.
Aerts A; Radiobiology Unit, Belgian Nuclear Research Centre, 2400 Mol, Belgium.
Leybaert L; Department of Basic and Applied Medical Sciences, Physiology Group, Ghent University, 9000 Ghent, Belgium.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Jun; Vol. 23 (6). Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article
MeSH Terms :
X-Rays*
Apolipoproteins E/*genetics
Atherosclerosis/*metabolism
Chemokine CXCL10/*metabolism
Endothelium, Vascular/*radiation effects
Growth Differentiation Factor 15/*metabolism
Animals ; Apolipoproteins E/deficiency ; Atherosclerosis/genetics ; Cell Adhesion Molecule-1/genetics ; Cell Adhesion Molecule-1/metabolism ; Cell Line ; Cells, Cultured ; Chemokine CCL2/genetics ; Chemokine CCL2/metabolism ; Chemokine CXCL10/genetics ; Endothelial Cells/metabolism ; Endothelial Cells/radiation effects ; Endothelium, Vascular/cytology ; Female ; Fibroblast Growth Factor 1/genetics ; Fibroblast Growth Factor 1/metabolism ; Growth Differentiation Factor 15/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; P-Selectin/genetics ; P-Selectin/metabolism ; Receptors, Urokinase Plasminogen Activator/genetics ; Receptors, Urokinase Plasminogen Activator/metabolism
Czasopismo naukowe
Tytuł :
GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH.
Autorzy :
Kim KH; GI Innovatioin, Inc., Tera Tower, Songpa-daero 167, Songpa-gu, Seoul 05855, South Korea. Electronic address: .
Lee MS; Severance Biomedical Science Institute and Dept. of Internal Medicine, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul 03722, South Korea. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 Mar; Vol. 1865 (3), pp. 129834. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging/*genetics
Growth Differentiation Factor 15/*genetics
Mitochondrial Myopathies/*genetics
Muscular Atrophy/*genetics
Non-alcoholic Fatty Liver Disease/*genetics
Obesity/*genetics
Aging/metabolism ; Animals ; Disease Models, Animal ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress/genetics ; Gene Expression Regulation ; Growth Differentiation Factor 15/metabolism ; Growth Differentiation Factor 15/therapeutic use ; Humans ; Mice ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Myopathies/metabolism ; Mitochondrial Myopathies/pathology ; Muscular Atrophy/metabolism ; Muscular Atrophy/pathology ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Obesity/metabolism ; Obesity/pathology ; Unfolded Protein Response
Czasopismo naukowe
Tytuł :
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise.
Autorzy :
Klein AB; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nicolaisen TS; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Ørtenblad N; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Gejl KD; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Jensen R; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Fritzen AM; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Larsen EL; Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
Karstoft K; Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.; Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Poulsen HE; Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
Morville T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sahl RE; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Helge JW; Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lund J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Falk S; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lyngbæk M; Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ellingsgaard H; Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Pedersen BK; Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Lu W; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.
Finan B; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.
Jørgensen SB; Global Obesity and LD Research, Novo Nordisk A/S, Maaloev, Denmark.
Seeley RJ; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
Kleinert M; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Kiens B; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Richter EA; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Clemmensen C; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 15; Vol. 12 (1), pp. 1041. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Appetite Regulation/*physiology
Exercise/*physiology
Feeding Behavior/*physiology
Glial Cell Line-Derived Neurotrophic Factor Receptors/*genetics
Growth Differentiation Factor 15/*genetics
Physical Endurance/*physiology
Adult ; Animals ; Creatine Kinase/blood ; Creatine Kinase/genetics ; Gene Expression Regulation ; Glial Cell Line-Derived Neurotrophic Factor Receptors/deficiency ; Growth Differentiation Factor 15/blood ; Growth Differentiation Factor 15/metabolism ; Humans ; Interleukin-10/blood ; Interleukin-10/genetics ; Interleukin-6/administration & dosage ; Leptin/blood ; Leptin/genetics ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Knockout ; Motivation/physiology ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Myocardium/metabolism ; Physical Conditioning, Animal ; Time Factors
Czasopismo naukowe
Tytuł :
[Study on the value of mitochondrial associated protein fumarylacetoacetate domain containing protein 1 and growth differentiation factor-15 in the diagnosis of sepsis: test results from the patients of a multicenter study].
Autorzy :
Li M; Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China.
Ren R; Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China.
Chen S; Department of Critical Care Medicine, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China. Corresponding author: Yan Jing, Email: .
Chen C; Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China.
Yan J; Department of Critical Care Medicine, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China. Corresponding author: Yan Jing, Email: .
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Źródło :
Zhonghua wei zhong bing ji jiu yi xue [Zhonghua Wei Zhong Bing Ji Jiu Yi Xue] 2021 Feb; Vol. 33 (2), pp. 180-185.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Growth Differentiation Factor 15*
Sepsis*/diagnosis
Acetoacetates ; Adult ; China ; Humans ; Hydrolases ; Mitochondrial Proteins ; Prognosis ; ROC Curve ; Retrospective Studies
Czasopismo naukowe
Tytuł :
AMPK mediates energetic stress-induced liver GDF15.
Autorzy :
Townsend LK; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.; Centre for Metabolism, Obesity and Diabetes Research and Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Weber AJ; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Day EA; Centre for Metabolism, Obesity and Diabetes Research and Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Shamshoum H; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Shaw SJ; Rigel Pharmaceuticals Inc., South San Francisco, CA, USA.
Perry CGR; School of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, ON, Canada.
Kemp BE; Department of Medicine, St. Vincent's Institute, University of Melbourne, Melbourne, Vic, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, Fitzroy, Victoria, Australia.
Steinberg GR; Centre for Metabolism, Obesity and Diabetes Research and Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Wright DC; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Jan; Vol. 35 (1), pp. e21218.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoplasmic Reticulum Stress*
AMP-Activated Protein Kinases/*metabolism
Growth Differentiation Factor 15/*metabolism
Liver/*metabolism
AMP-Activated Protein Kinases/genetics ; Animals ; Growth Differentiation Factor 15/genetics ; Mice ; Mice, Knockout ; Transcription Factor CHOP/genetics ; Transcription Factor CHOP/metabolism
Czasopismo naukowe
Tytuł :
Treatment with GDF15, a TGFβ superfamily protein, induces protective effect on retinal ganglion cells.
Autorzy :
Iwata Y; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.
Inagaki S; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.
Morozumi W; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.
Nakamura S; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.
Hara H; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.
Shimazawa M; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2021 Jan; Vol. 202, pp. 108338. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Growth Differentiation Factor 15/*pharmacology
Optic Nerve Injuries/*prevention & control
Retinal Degeneration/*prevention & control
Retinal Ganglion Cells/*drug effects
Animals ; Blotting, Western ; Cells, Cultured ; Disease Models, Animal ; Glial Fibrillary Acidic Protein/metabolism ; Growth Differentiation Factor 15/metabolism ; Immunohistochemistry ; Male ; Mice ; Microscopy, Confocal ; Nerve Crush ; Optic Nerve Injuries/metabolism ; Rats ; Rats, Sprague-Dawley ; Retinal Degeneration/metabolism ; Retinal Ganglion Cells/metabolism ; Tissue Distribution ; Transforming Growth Factor beta/pharmacology
Czasopismo naukowe
Tytuł :
Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway.
Autorzy :
L'homme L; Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, University of Lille, F-59000 Lille, France.; Laboratory of Virology and Immunology, University of Liege, GIGA-Signal Transduction, 4000 Liege, Belgium.
Sermikli BP; Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, University of Lille, F-59000 Lille, France.
Staels B; Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, University of Lille, F-59000 Lille, France.
Piette J; Laboratory of Virology and Immunology, University of Liege, GIGA-Signal Transduction, 4000 Liege, Belgium.
Legrand-Poels S; Laboratory of Virology and Immunology, University of Liege, GIGA-Signal Transduction, 4000 Liege, Belgium.
Dombrowicz D; Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, University of Lille, F-59000 Lille, France.
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Źródło :
Nutrients [Nutrients] 2020 Dec 08; Vol. 12 (12). Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article
MeSH Terms :
Eukaryotic Initiation Factor-2/*metabolism
Fatty Acids/*pharmacology
Growth Differentiation Factor 15/*metabolism
Macrophages/*metabolism
Signal Transduction/*drug effects
Transcription Factor CHOP/*metabolism
eIF-2 Kinase/*metabolism
Cell Survival/drug effects ; Diet ; Endoplasmic Reticulum Stress/drug effects ; Fatty Acids, Nonesterified ; Fatty Acids, Unsaturated ; Gene Expression Regulation/drug effects ; Growth Differentiation Factor 15/genetics ; Humans ; Lipid Metabolism ; Obesity/metabolism ; RNA, Small Interfering ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes.
Autorzy :
Chung JO; Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, 501-757, Republic of Korea.
Park SY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, 501-757, Republic of Korea. .
Cho DH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, 501-757, Republic of Korea.
Chung DJ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, 501-757, Republic of Korea.
Chung MY; Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, 501-757, Republic of Korea. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 25; Vol. 10 (1), pp. 20568. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2/*metabolism
Diabetic Retinopathy/*metabolism
Growth Differentiation Factor 15/*metabolism
Adult ; Aged ; Cross-Sectional Studies ; Female ; Growth Differentiation Factor 15/blood ; Growth Differentiation Factors/blood ; Growth Differentiation Factors/metabolism ; Humans ; Male ; Middle Aged ; Republic of Korea/epidemiology ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin.
Autorzy :
Ouyang J; Chongqing Public Health Medical Center, Chongqing, China.; Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, Canada.; Chronic Viral Illness Service, McGill University Health Centre, Montréal, QC, Canada.
Isnard S; Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, Canada.; Chronic Viral Illness Service, McGill University Health Centre, Montréal, QC, Canada.; CIHR Canadian HIV Trials Network, Vancouver, BC, Canada.
Lin J; Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, Canada.; Chronic Viral Illness Service, McGill University Health Centre, Montréal, QC, Canada.
Fombuena B; Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, Canada.; Chronic Viral Illness Service, McGill University Health Centre, Montréal, QC, Canada.; Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada.
Peng X; Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, Canada.; Chronic Viral Illness Service, McGill University Health Centre, Montréal, QC, Canada.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Chen Y; Chongqing Public Health Medical Center, Chongqing, China.
Routy JP; Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, Canada.; Chronic Viral Illness Service, McGill University Health Centre, Montréal, QC, Canada.; Division of Hematology, McGill University Health Centre, Montréal, QC, Canada.
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Źródło :
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2020 Nov 18; Vol. 11, pp. 581839. Date of Electronic Publication: 2020 Nov 18 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Diabetes Mellitus/*drug therapy
Gene Expression Regulation/*drug effects
Growth Differentiation Factor 15/*metabolism
Hypoglycemic Agents/*therapeutic use
Metformin/*therapeutic use
Weight Loss/*drug effects
Case-Control Studies ; Diabetes Mellitus/pathology ; Growth Differentiation Factor 15/genetics ; Humans
Czasopismo naukowe
Tytuł :
Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism.
Autorzy :
Hansen ES; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.
Hindberg K; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.
Latysheva N; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.
Aukrust P; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.; Research Institute of Internal Medicine, and.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; and.
Ueland T; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.; Research Institute of Internal Medicine, and.
Hansen JB; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.; Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
Brækkan SK; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.; Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
Morelli VM; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.
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Corporate Authors :
INVENT Consortium
Źródło :
Blood [Blood] 2020 Oct 15; Vol. 136 (16), pp. 1863-1870.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Susceptibility*
Biomarkers/*blood
Growth Differentiation Factor 15/*blood
Venous Thromboembolism/*blood
Venous Thromboembolism/*etiology
Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Growth Differentiation Factor 15/genetics ; Humans ; Male ; Odds Ratio ; Polymorphism, Single Nucleotide ; Prognosis ; Risk Assessment ; Risk Factors ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology
Czasopismo naukowe
Tytuł :
[The association of growth differentiation factor 15 (GDF-15) level with extent of left atrial fibrosis in patients with nonvalvular atrial fibrillation].
Autorzy :
Gizatulina TP; Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Martyanova LU; Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Petelina TI; Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Zueva EV; Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Shirokov NE; Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Kolunin GV; Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Belonogov DV; Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Gorbatenko EA; Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
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Źródło :
Kardiologiia [Kardiologiia] 2020 Oct 14; Vol. 60 (9), pp. 22-29. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Atrial Appendage*
Atrial Fibrillation*/complications
Atrial Fibrillation*/diagnosis
Atrial Fibrillation*/pathology
Catheter Ablation*
Growth Differentiation Factor 15*/blood
Adult ; Aged ; Female ; Fibrosis ; Heart Atria/diagnostic imaging ; Heart Atria/pathology ; Humans ; Middle Aged
Czasopismo naukowe
Tytuł :
Activated HIF1α of tumor cells promotes chemoresistance development via recruiting GDF15-producing tumor-associated macrophages in gastric cancer.
Autorzy :
Yu S; Department of Medical Oncology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Li Q; Department of Medical Oncology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Yu Y; Department of Medical Oncology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Cui Y; Department of Medical Oncology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Li W; Department of Medical Oncology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Liu T; Department of Medical Oncology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. .
Liu F; Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Oct; Vol. 69 (10), pp. 1973-1987. Date of Electronic Publication: 2020 May 09.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Growth Differentiation Factor 15/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Macrophages/*immunology
Stomach Neoplasms/*pathology
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Female ; Growth Differentiation Factor 15/genetics ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Macrophages/drug effects ; Macrophages/metabolism ; Macrophages/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Nude ; Signal Transduction ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/immunology ; Stomach Neoplasms/metabolism ; Tumor Cells, Cultured ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
GDF15 Repression Contributes to 5-Fluorouracil Resistance in Human Colon Cancer by Regulating Epithelial-Mesenchymal Transition and Apoptosis.
Autorzy :
Wang B; Department of Medical Administration, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Ma N; Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Zheng X; Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Li X; Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Ma X; Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Hu J; Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Cao B; Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
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Źródło :
BioMed research international [Biomed Res Int] 2020 Sep 28; Vol. 2020, pp. 2826010. Date of Electronic Publication: 2020 Sep 28 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Colonic Neoplasms*/metabolism
Colonic Neoplasms*/pathology
Growth Differentiation Factor 15*/metabolism
Growth Differentiation Factor 15*/pharmacology
Drug Resistance, Neoplasm/*drug effects
Fluorouracil/*pharmacology
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Humans ; Male ; Mice, Nude
Czasopismo naukowe
Tytuł :
Relationship between GDF15 level and bone metabolism in postmenopausal Chinese women.
Autorzy :
Li W; Department of Endocrinology, Xiangya Hospital of Central South University, Changsha, PR China.
Li C; Department of Endocrinology, Xiangya Hospital of Central South University, Changsha, PR China.
Zhou X; Department of Endocrinology, Xiangya Hospital of Central South University, Changsha, PR China.
Jiang T; Department of Endocrinology, Xiangya Hospital of Central South University, Changsha, PR China.
Guo L; Department of Endocrinology, Xiangya Hospital of Central South University, Changsha, PR China.
Liu H; Department of Orthopedic, Xiangya Hospital of Central South University, Changsha, PR China.
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Źródło :
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2020 Aug; Vol. 36 (8), pp. 714-717. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Bone and Bones/*metabolism
Growth Differentiation Factor 15/*blood
Postmenopause/*blood
Aged ; Asian Continental Ancestry Group ; Biomarkers/blood ; Biomarkers/metabolism ; Body Mass Index ; Bone Density ; Bone Remodeling/physiology ; China ; Cross-Sectional Studies ; Growth Differentiation Factor 15/physiology ; Humans ; Middle Aged ; Osteoporosis, Postmenopausal/blood ; Osteoporosis, Postmenopausal/ethnology ; Postmenopause/ethnology
Czasopismo naukowe
Tytuł :
The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling.
Autorzy :
Worth AA; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
Shoop R; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
Tye K; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
Feetham CH; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
D'Agostino G; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Rowett Institute, University of Aberdeen, Aberdeen, United Kingdom.
Dodd GT; School of Biomedical Sciences, The University of Melbourne, Victoria, Australia.
Reimann F; Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
Gribble FM; Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
Beebe EC; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Dunbar JD; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Alexander-Chacko JT; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Sindelar DK; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Coskun T; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Emmerson PJ; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Luckman SM; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
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Źródło :
ELife [Elife] 2020 Jul 29; Vol. 9. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Anorexia/*genetics
Brain Stem/*physiology
Growth Differentiation Factor 15/*genetics
Neurons/*physiology
Pica/*genetics
Animals ; Cholecystokinin/metabolism ; Growth Differentiation Factor 15/administration & dosage ; Growth Differentiation Factor 15/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/administration & dosage
Czasopismo naukowe
Tytuł :
Plasma growth differentiation factor 15 levels for predicting serious adverse events and bleeding in acute pulmonary embolism: a prospective observational study.
Autorzy :
Skowrońska M; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland. />Skrzyńska M; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland
Machowski M; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland
Bartoszewicz Z; Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland
Paczyńska M; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland
Ou-Pokrzewińska A; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland
Kurnicka K; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland
Ciurzyński M; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland
Roik M; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland
Wiśniewska M; 1st Department of Radiology, Medical University of Warsaw, Warsaw, Poland
Palczewski P; 1st Department of Radiology, Medical University of Warsaw, Warsaw, Poland
Pruszczyk P; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland
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Źródło :
Polish archives of internal medicine [Pol Arch Intern Med] 2020 Sep 30; Vol. 130 (9), pp. 757-765. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Growth Differentiation Factor 15*
Pulmonary Embolism*/diagnosis
Acute Disease ; Humans ; Plasma ; Prospective Studies
Czasopismo naukowe
Tytuł :
Increased Growth Differentiation Factor 15 in Patients with Hypoleptinemia-Associated Lipodystrophy.
Autorzy :
Kralisch S; Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.; IFB AdiposityDiseases, Leipzig University Medical Center, University of Leipzig, 04103 Leipzig, Germany.
Hoffmann A; Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
Estrada-Kunz J; Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
Stumvoll M; Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
Fasshauer M; Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.; IFB AdiposityDiseases, Leipzig University Medical Center, University of Leipzig, 04103 Leipzig, Germany.; Department of Nutritional Sciences, University of Giessen, 35390 Gieβen, Germany.
Tönjes A; Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
Miehle K; Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 29; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Growth Differentiation Factor 15/*blood
Leptin/*blood
Lipodystrophy/*blood
Obesity/*blood
Sterol Regulatory Element Binding Protein 2/*genetics
Adipose Tissue/metabolism ; Animals ; Biomarkers/blood ; C-Reactive Protein/metabolism ; Female ; Gene Expression Regulation/genetics ; Glycated Hemoglobin A/metabolism ; Growth Differentiation Factor 15/genetics ; Humans ; Insulin Resistance/genetics ; Lipodystrophy/genetics ; Lipodystrophy/pathology ; Male ; Mice ; Mice, Transgenic ; Middle Aged ; Obesity/genetics ; Obesity/pathology ; Triglycerides/blood
Czasopismo naukowe
Tytuł :
Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice.
Autorzy :
Moschovaki-Filippidou F; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Steiger S; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Lorenz G; Klinikum rechts der Isar, Department of Nephrology, Technical University Munich, 81675 München, Germany.
Schmaderer C; Klinikum rechts der Isar, Department of Nephrology, Technical University Munich, 81675 München, Germany.
Ribeiro A; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
von Rauchhaupt E; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Cohen CD; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Anders HJ; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Lindenmeyer M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Lech M; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 23; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement/*immunology
Glomerular Basement Membrane/*immunology
Glomerulonephritis, Membranous/*immunology
Growth Differentiation Factor 15/*immunology
Proteinuria/*immunology
T-Lymphocytes/*immunology
Animals ; Cell Movement/genetics ; Chemokine CXCL10/genetics ; Chemokine CXCL10/immunology ; Glomerular Basement Membrane/pathology ; Glomerulonephritis, Membranous/genetics ; Glomerulonephritis, Membranous/pathology ; Growth Differentiation Factor 15/genetics ; Mice ; Mice, Knockout ; Proteinuria/genetics ; Proteinuria/pathology ; Receptors, CXCR3/genetics ; Receptors, CXCR3/immunology ; T-Lymphocytes/pathology
Czasopismo naukowe

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