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Tytuł :
Mechanisms of homocysteine-induced damage to the endothelial, medial and adventitial layers of the arterial wall.
Autorzy :
Balint B; INSERM U1256 Nutrition-Genetics and Environmental Exposure, Medical Faculty and University Hospital Center, Nancy University, 54500, Vandoeuvre-lès-Nancy, France. Electronic address: .
Jepchumba VK; INSERM U1256 Nutrition-Genetics and Environmental Exposure, Medical Faculty and University Hospital Center, Nancy University, 54500, Vandoeuvre-lès-Nancy, France.
Guéant JL; INSERM U1256 Nutrition-Genetics and Environmental Exposure, Medical Faculty and University Hospital Center, Nancy University, 54500, Vandoeuvre-lès-Nancy, France. Electronic address: Jean-Louis.Gueant@univ-lorraine.fr.
Guéant-Rodriguez RM; INSERM U1256 Nutrition-Genetics and Environmental Exposure, Medical Faculty and University Hospital Center, Nancy University, 54500, Vandoeuvre-lès-Nancy, France.
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Źródło :
Biochimie [Biochimie] 2020 Jun; Vol. 173, pp. 100-106. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Arteries/*pathology
Cardiovascular Diseases/*pathology
Homocysteine/*adverse effects
Animals ; Arteries/metabolism ; Cardiovascular Diseases/metabolism ; Cells, Cultured ; Endothelium, Vascular/pathology ; Homocysteine/blood ; Humans
Czasopismo naukowe
Tytuł :
Genetic, epigenetic and genomic mechanisms of methionine dependency of cancer and tumor-initiating cells: What could we learn from folate and methionine cycles.
Autorzy :
Guéant JL; INSERM UMR_S 1256 NGERE - Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, University of Lorraine, Nancy (Vandoeuvre-lès-Nancy), F-54000, France. Electronic address: jean-louis.gueant@univ-lorraine.fr.
Oussalah A; INSERM UMR_S 1256 NGERE - Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, University of Lorraine, Nancy (Vandoeuvre-lès-Nancy), F-54000, France.
Zgheib R; INSERM UMR_S 1256 NGERE - Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, University of Lorraine, Nancy (Vandoeuvre-lès-Nancy), F-54000, France.
Siblini Y; INSERM UMR_S 1256 NGERE - Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, University of Lorraine, Nancy (Vandoeuvre-lès-Nancy), F-54000, France.
Hsu SB; INSERM UMR_S 1256 NGERE - Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, University of Lorraine, Nancy (Vandoeuvre-lès-Nancy), F-54000, France.
Namour F; INSERM UMR_S 1256 NGERE - Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, University of Lorraine, Nancy (Vandoeuvre-lès-Nancy), F-54000, France.
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Źródło :
Biochimie [Biochimie] 2020 Jun; Vol. 173, pp. 123-128. Date of Electronic Publication: 2020 Apr 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Folic Acid/*metabolism
Homocysteine/*metabolism
Methionine/*metabolism
Neoplasms/*metabolism
Neoplastic Stem Cells/*metabolism
Vitamin B 12/*metabolism
Cell Line, Tumor ; Epigenesis, Genetic ; Humans ; Neoplasms/pathology ; Neoplastic Stem Cells/pathology
Czasopismo naukowe
Tytuł :
MTHFR 677C → T genotype modulates the effect of a 5-year supplementation with B-vitamins on homocysteine concentration: The SU.FOL.OM3 randomized controlled trial.
Autorzy :
Fezeu LK; Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, Bobigny, France.
Ducros V; Département de Biochimie Pharmacologie et Toxicologie, UM Biochimie Nutritionnelle et Hormonale, Institut de Biologie et Pathologie, Centre Hospitalier Universitaire, Grenoble, France.
Guéant JL; Inserm U724, Pathologies Cellulaire et Moléculaire en Nutrition, Faculté de Médecine, Université Henry Poincaré, Vandoeuvre lès Nancy, France.
Guilland JC; LPPCE, Faculté de Médecine, Université de Bourgogne, Dijon, France.
Andreeva VA; Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, Bobigny, France.
Hercberg S; Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, Bobigny, France.; Département de Santé Publique, Hôpital Avicenne, Bobigny, France.
Galan P; Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, Bobigny, France.
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Źródło :
PloS one [PLoS One] 2018 May 29; Vol. 13 (5), pp. e0193352. Date of Electronic Publication: 2018 May 29 (Print Publication: 2018).
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Dietary Supplements*
Polymorphism, Genetic*
Cardiovascular Diseases/*drug therapy
Homocysteine/*blood
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
Vitamin B Complex/*administration & dosage
Cardiovascular Diseases/genetics ; Cardiovascular Diseases/physiopathology ; Double-Blind Method ; Female ; Genotype ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Autorzy :
Oussalah A; Department of Molecular Medicine and Personalized Therapeutics.; Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, and.; INSERM, Unité 954, Nutrition, Genetics, and Environmental Risk Exposure, Faculty of Medicine of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France.
Levy J; Department of Molecular Medicine and Personalized Therapeutics.; Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, and.
Filhine-Trésarrieu P; Department of Molecular Medicine and Personalized Therapeutics.; Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, and.; INSERM, Unité 954, Nutrition, Genetics, and Environmental Risk Exposure, Faculty of Medicine of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France.
Namour F; Department of Molecular Medicine and Personalized Therapeutics.; Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, and.; INSERM, Unité 954, Nutrition, Genetics, and Environmental Risk Exposure, Faculty of Medicine of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France.
Guéant JL; Department of Molecular Medicine and Personalized Therapeutics, jean-louis.gueant@univ-lorraine.fr.; Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, and.; INSERM, Unité 954, Nutrition, Genetics, and Environmental Risk Exposure, Faculty of Medicine of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France.
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Źródło :
The American journal of clinical nutrition [Am J Clin Nutr] 2017 Oct; Vol. 106 (4), pp. 1142-1156. Date of Electronic Publication: 2017 Aug 16.
Typ publikacji :
Journal Article; Meta-Analysis; Review; Systematic Review
MeSH Terms :
Alleles*
Genotype*
Polymorphism, Single Nucleotide*
Homocysteine/*blood
Transcobalamins/*genetics
Vitamin B 12/*blood
Vitamin B 12 Deficiency/*genetics
Adult ; Aged ; Alzheimer Disease/etiology ; Alzheimer Disease/genetics ; Carbon/blood ; Child ; Congenital Abnormalities/etiology ; Congenital Abnormalities/genetics ; European Continental Ancestry Group/genetics ; Female ; Humans ; Male ; Methylmalonic Acid/metabolism ; Neoplasms/etiology ; Neoplasms/genetics ; Transcobalamins/metabolism ; Vitamin B 12 Deficiency/blood ; Vitamin B 12 Deficiency/complications
Czasopismo naukowe
Tytuł :
Early methyl donor deficiency produces severe gastritis in mothers and offspring through N-homocysteinylation of cytoskeleton proteins, cellular stress, and inflammation.
Autorzy :
Bossenmeyer-Pourié C; Institut National de la Santé et de la Recherche Médicale, U954, Nutrition, Génétique et Exposition aux Risques Environnementaux, Vandoeuvre, France.
Pourié G
Koziel V
Helle D
Jeannesson E
Guéant JL
Beck B
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2013 Jun; Vol. 27 (6), pp. 2185-97. Date of Electronic Publication: 2013 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Cytoskeletal Proteins/*metabolism
Gastritis/*etiology
Gastritis/*pathology
Homocysteine/*metabolism
Inflammation/*etiology
Inflammation/*pathology
Oxidative Stress/*physiology
Animals ; Animals, Newborn ; Animals, Suckling ; Cadherins/metabolism ; Female ; Fetus ; Gastritis/metabolism ; Inflammation/metabolism ; Methylation ; Mothers ; Pregnancy ; Rats ; Rats, Wistar ; Severity of Illness Index ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Homocysteinylation of neuronal proteins contributes to folate deficiency-associated alterations of differentiation, vesicular transport, and plasticity in hippocampal neuronal cells.
Autorzy :
Akchiche N; Inserm U954, Faculté de Médecine, 9 Avenue de la Forêt de Haye, F-54500 Vandoeuvre-lès-Nancy, France.
Bossenmeyer-Pourié C
Kerek R
Martin N
Pourié G
Koziel V
Helle D
Alberto JM
Ortiou S
Camadro JM
Léger T
Guéant JL
Daval JL
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2012 Oct; Vol. 26 (10), pp. 3980-92. Date of Electronic Publication: 2012 Jun 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Folic Acid/*pharmacology
Folic Acid Deficiency/*metabolism
Hippocampus/*cytology
Homocysteine/*pharmacology
Neurons/*cytology
Neurons/*drug effects
Animals ; Blotting, Western ; Cell Differentiation/drug effects ; Cell Line ; Cell Movement/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Hep G2 Cells ; Humans ; Immunohistochemistry ; Neurons/metabolism ; Protein Binding ; Rats ; Rats, Wistar ; Real-Time Polymerase Chain Reaction ; Vitamin B 12/pharmacology
Czasopismo naukowe
Tytuł :
Increased homocysteinemia is associated with beneficial effects on body weight after long-term high-protein, low-fat diet in rats.
Autorzy :
Beck B; INSERM, U954, Nutrition, Génétique et Expositions aux Risques Environnementaux, Vandœuvre-les-Nancy, France. />Bossenmeyer-Pourié C
Jeannesson E
Richy S
Guéant JL
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Źródło :
Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2012 Sep; Vol. 28 (9), pp. 932-6. Date of Electronic Publication: 2012 May 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diet, Fat-Restricted*
Hyperhomocysteinemia*/metabolism
Adipose Tissue/*metabolism
Dietary Proteins/*pharmacology
Homocysteine/*blood
Obesity/*prevention & control
Weight Gain/*drug effects
Animals ; Energy Intake ; Folic Acid/blood ; Male ; Rats ; Rats, Long-Evans
Czasopismo naukowe
Tytuł :
Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an ambulatory elderly population.
Autorzy :
Guéant-Rodriguez RM; Inserm U954, Medical Faculty and CHU of Nancy, University Henri Poincaré, Nancy, France. />Spada R
Moreno-Garcia M
Anello G
Bosco P
Lagrost L
Romano A
Elia M
Guéant JL
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Źródło :
Atherosclerosis [Atherosclerosis] 2011 Feb; Vol. 214 (2), pp. 480-5. Date of Electronic Publication: 2010 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ankle Brachial Index*
Independent Living*
Walking*
Apolipoprotein A-I/*blood
Homocysteine/*blood
Peripheral Arterial Disease/*blood
Age Factors ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Cholesterol, HDL/blood ; Female ; Folic Acid/blood ; Humans ; Male ; Methylmalonic Acid/blood ; Middle Aged ; Particle Size ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/physiopathology ; Regression Analysis ; Risk Assessment ; Risk Factors ; Sicily ; Vitamin B 12/blood
Czasopismo naukowe
Tytuł :
Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway.
Autorzy :
Alberto JM; INSERM U724, Faculte de Médecine, Vandoeuvre-lès-Nancy, France.
Hamelet J
Noll C
Blaise S
Bronowicki JP
Guéant JL
Delabar JM
Janel N
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Źródło :
Molecular genetics and metabolism [Mol Genet Metab] 2007 Aug; Vol. 91 (4), pp. 396-8. Date of Electronic Publication: 2007 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homocysteine/*metabolism
Homocystinuria/*genetics
Homocystinuria/*metabolism
Animals ; Cystathionine beta-Synthase/genetics ; Disease Models, Animal ; Methylation ; Mice ; MicroRNAs/genetics
Czasopismo naukowe
Tytuł :
Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteine.
Autorzy :
Peyrin-Biroulet L; Inserm, U724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Nancy-Universitè Vandoeuvre-les-Nancy, F-54511, France.
Rodriguez-Guéant RM
Chamaillard M
Desreumaux P
Xia B
Bronowicki JP
Bigard MA
Guéant JL
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Źródło :
The American journal of gastroenterology [Am J Gastroenterol] 2007 May; Vol. 102 (5), pp. 1108-15. Date of Electronic Publication: 2007 Mar 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Homocysteine/*physiology
Hyperhomocysteinemia/*complications
Inflammatory Bowel Diseases/*etiology
Thromboembolism/*etiology
Animals ; Folic Acid Deficiency/complications ; Humans ; Hyperhomocysteinemia/etiology ; Hyperhomocysteinemia/genetics ; Oxidative Stress ; Risk Factors ; Vitamin B 12 Deficiency/complications
Czasopismo naukowe
Tytuł :
Coffee and diabetes: is homocysteine the missing link?
Autorzy :
Peyrin-Biroulet L
Guéant JL
Roblin X
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Źródło :
Archives of internal medicine [Arch Intern Med] 2007 Jan 22; Vol. 167 (2), pp. 204; author reply 205.
Typ publikacji :
Comment; Letter
MeSH Terms :
Coffee*
Diabetes Mellitus, Type 2/*etiology
Homocysteine/*blood
Diabetes Mellitus, Type 2/prevention & control ; Humans ; Hyperhomocysteinemia/complications ; Multivariate Analysis ; Regression Analysis
Opinia redakcyjna
Tytuł :
Association of vitamin B12, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily.
Autorzy :
Spada RS; Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina (EN), Italy. />Stella G
Calabrese S
Bosco P
Anello G
Guéant-Rodriguez RM
Romano A
Benamghar L
Fontaine T
Guéant JL
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Źródło :
Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2007; Vol. 45 (2), pp. 136-42.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*blood
Folic Acid/*blood
Homocysteine/*blood
Vitamin B 12/*blood
Aged ; Aged, 80 and over ; Aging/physiology ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology ; Diabetes Mellitus/blood ; Diabetes Mellitus/epidemiology ; Humans ; Middle Aged ; Neoplasms/blood ; Neoplasms/epidemiology ; Peripheral Vascular Diseases ; Sicily/epidemiology ; Stroke
Czasopismo naukowe
Tytuł :
Association of thyroid dysfunction with vitamin B12, folate and plasma homocysteine levels in the elderly: a population-based study in Sicily.
Autorzy :
Stella G; Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina (EN), Italy.
Spada RS
Calabrese S
Bosco P
Anello G
Guéant-Rodriguez RM
Romano A
Benamghar L
Proto C
Castellano A
Fajardo A
Lipari L
Sirna S
Guéant JL
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Źródło :
Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2007; Vol. 45 (2), pp. 143-7.
Typ publikacji :
Journal Article
MeSH Terms :
Aging/*pathology
Folic Acid/*blood
Homocysteine/*blood
Thyroid Diseases/*epidemiology
Vitamin B 12/*blood
Aged ; Aged, 80 and over ; Aging/blood ; Epidemiology ; Female ; Humans ; Male ; Middle Aged ; Sicily/epidemiology ; Thyroid Diseases/blood
Czasopismo naukowe
Tytuł :
Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily.
Autorzy :
Bosco P; IRCCS Associazione Oasi Maria S.S.- Institute for Research on Mental Retardation and Brain Aging, 94018 Troina (EN), Italy. />Guéant-Rodriguez RM
Anello G
Spada R
Romano A
Fajardo A
Caraci F
Ferri R
Guéant JL
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Źródło :
Thrombosis and haemostasis [Thromb Haemost] 2006 Aug; Vol. 96 (2), pp. 154-9.
Typ publikacji :
Journal Article
MeSH Terms :
Cerebrovascular Disorders/*genetics
Homocysteine/*genetics
Ischemia/*pathology
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
Aged ; Female ; Ferredoxin-NADP Reductase/genetics ; Homocysteine/chemistry ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic ; Sicily ; Transcobalamins/metabolism
Czasopismo naukowe
Tytuł :
Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations.
Autorzy :
Guéant-Rodriguez RM; INSERM U-724, Cellular and Molecular Pathology in Nutrition, Faculté de Médecine, University Henry Poincaré of Nancy, Vandoeuvre lès Nancy, France.
Guéant JL
Debard R
Thirion S
Hong LX
Bronowicki JP
Namour F
Chabi NW
Sanni A
Anello G
Bosco P
Romano C
Amouzou E
Arrieta HR
Sánchez BE
Romano A
Herbeth B
Guilland JC
Mutchinick OM
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Źródło :
The American journal of clinical nutrition [Am J Clin Nutr] 2006 Mar; Vol. 83 (3), pp. 701-7.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Genetic*
Folic Acid/*blood
Homocysteine/*blood
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
Vitamin B 12/*blood
Adolescent ; Adult ; Africa, Western ; Alleles ; Europe ; Female ; Gene Frequency ; Genotype ; Humans ; Male ; Mexico ; Middle Aged ; Regression Analysis
Czasopismo naukowe
Tytuł :
The association between plasma homocysteine and holo-transcobalamin and the transcobalamin 776C-->G polymorphism is influenced by folate in the absence of supplementation and fortified diet.
Autorzy :
Guéant JL
Xiaohong L
Ortiou S
Gérard P
Shue S
Namour F
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Źródło :
The American journal of clinical nutrition [Am J Clin Nutr] 2006 Jan; Vol. 83 (1), pp. 171-2.
Typ publikacji :
Comment; Letter
MeSH Terms :
Food, Fortified*
Folic Acid/*administration & dosage
Homocysteine/*blood
Transcobalamins/*metabolism
Humans
Opinia redakcyjna
Tytuł :
Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.
Autorzy :
Guéant-Rodriguez RM; INSERM U-724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Vandoeuvre-les-Nancy Cedex, France. />Juilliére Y
Candito M
Adjalla CE
Gibelin P
Herbeth B
Van Obberghen E
Gueánt JL
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Źródło :
Thrombosis and haemostasis [Thromb Haemost] 2005 Sep; Vol. 94 (3), pp. 510-5.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Polymorphism, Genetic*
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/*genetics
Coronary Artery Disease/*genetics
Ferredoxin-NADP Reductase/*genetics
Homocysteine/*blood
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
Aged ; Alleles ; Case-Control Studies ; Coronary Artery Disease/blood ; European Continental Ancestry Group ; Female ; Folic Acid/blood ; France ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Transcobalamins ; Vitamin B 12/blood
Czasopismo naukowe
Tytuł :
Mild neonatal hypoxia exacerbates the effects of vitamin-deficient diet on homocysteine metabolism in rats.
Autorzy :
Blaise S; INSERM U 724, Université H. Poincaré, 54505 Vandoeuvre-lès-Nancy, France.
Alberto JM
Nédélec E
Ayav A
Pourié G
Bronowicki JP
Guéant JL
Daval JL
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Źródło :
Pediatric research [Pediatr Res] 2005 Jun; Vol. 57 (6), pp. 777-82. Date of Electronic Publication: 2005 Apr 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Avitaminosis/*complications
Avitaminosis/*metabolism
Homocysteine/*metabolism
Hypoxia/*complications
Hypoxia/*metabolism
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/genetics ; Animals ; Animals, Newborn ; Avitaminosis/genetics ; Base Sequence ; Cystathionine beta-Synthase/genetics ; Female ; Hypoxia/genetics ; Maternal-Fetal Exchange ; Methylenetetrahydrofolate Reductase (NADPH2)/metabolism ; Pregnancy ; Pregnancy Complications/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease.
Autorzy :
Anello G; IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina (EN), Italy.
Guéant-Rodríguez RM
Bosco P
Guéant JL
Romano A
Namour B
Spada R
Caraci F
Pourié G
Daval JL
Ferri R
Pokaż więcej
Źródło :
Neuroreport [Neuroreport] 2004 Apr 09; Vol. 15 (5), pp. 859-61.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Polymorphism, Genetic*
Alzheimer Disease/*blood
Homocysteine/*blood
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
Age Factors ; Aged ; Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Apolipoprotein E4 ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; Case-Control Studies ; Confidence Intervals ; Female ; Humans ; Male ; Methylenetetrahydrofolate Reductase (NADPH2)/metabolism ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Pteroylpolyglutamic Acids/therapeutic use ; Regression Analysis ; Statistics, Nonparametric ; Transcobalamins/genetics ; Transcobalamins/metabolism ; Vitamin B 12/therapeutic use
Czasopismo naukowe

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