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Wyświetlanie 1-12 z 12
Tytuł:
The Role of FAS Receptor Methylation in Osteosarcoma Metastasis.
Autorzy:
Sun JM; Program of Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Chow WY; Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Children's Cancer and Hematology Center, Houston, TX 77030, USA.
Xu G; Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Children's Cancer and Hematology Center, Houston, TX 77030, USA.
Hicks MJ; Department of Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.
Nakka M; Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Children's Cancer and Hematology Center, Houston, TX 77030, USA.
Shen J; Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Children's Cancer and Hematology Center, Houston, TX 77030, USA.
Ng PKS; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Taylor AM; Program of Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Yu A; Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Children's Cancer and Hematology Center, Houston, TX 77030, USA.
Farrar JE; Arkansas Children's Research Institute and Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Barkauskas DA; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Gorlick R; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Guidry Auvil JM; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD 20892, USA.
Gerhard D; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD 20892, USA.
Meltzer P; Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Guerra R; Department of Statistics, Rice University, Houston, TX 77005, USA.
Man TK; Program of Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Children's Cancer and Hematology Center, Houston, TX 77030, USA.
Lau CC; Program of Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Children's Cancer and Hematology Center, Houston, TX 77030, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.; Center for Cancer and Blood Disorders, Connecticut Children's Medical Center, Hartford, CT 06106, USA.
On Behalf Of The Target Osteosarcoma Consortium
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 29; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 29.
Typ publikacji:
Journal Article
MeSH Terms:
Bone Neoplasms*/metabolism
Osteosarcoma*/metabolism
Mice ; Animals ; fas Receptor/genetics ; fas Receptor/metabolism ; Azacitidine/pharmacology ; DNA Methylation ; CpG Islands ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
The Data Use Ontology to streamline responsible access to human biomedical datasets.
Autorzy:
Lawson J; Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.
Cabili MN; Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.
Kerry G; European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Boughtwood T; Australian Genomics, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Thorogood A; Centre of Genomics and Policy, Department of Human Genetics, McGill University, Montreal, QC, Canada.; ELIXIR-Luxembourg, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
Alper P; ELIXIR-Luxembourg, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
Bowers SR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Boyles RR; RTI International, Research Triangle Park, NC, USA.
Brookes AJ; University of Leicester, Leicester, UK.
Brush M; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Burdett T; European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Clissold H; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Donnelly S; Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.
Dyke SOM; McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, Department of Neurology & Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Freeberg MA; European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Haendel MA; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Hata C; Bioinformation and DDBJ Center, National Institute of Genetics, Mishima, Japan.
Holub P; BBMRI-ERIC, AT and Masaryk University, Brno, Czech Republic.
Jeanson F; University Health Network, Toronto, ON, Canada.
Jene A; Centre de Regulació Genòmica (CRG), Barcelona, Spain.
Kawashima M; National Bioscience Database Center, Japan Science and Technology Agency, Tokyo, Japan.
Kawashima S; Database Center for Life Science, Joint Support-Center for Data Science Research, Research Organization of Information and Systems, Kashiwa, Japan.
Konopko M; ELIXIR Hub, Wellcome Genome Campus, Hinxton, UK.
Kyomugisha I; Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Li H; Canada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Linden M; ELIXIR-Finland, CSC - IT Center for Science Ltd, Espoo, Finland.
Rodriguez LL; Patient-Centered Outcomes Research Institute, Washington, DC, USA.
Morita M; Okayama University, Okayama, Japan.
Mulder N; Computational Biology Division, IDM, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Muller J; Laboratoire de Génétique Médicale, Institut de Génétique Médicale d'Alsace, INSERM U1112, Université; de Strasbourg, Strasbourg, France.; Laboratoire de Diagnostic Génétique, Institut de Génétique Médicale d'Alsace, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Nagaie S; Tohoku Medical Megabank Organization (ToMMo), Tohoku University, Sendai, Japan.
Nasir J; Department of Life Sciences, University of Northampton, Northampton, UK.
Ogishima S; Tohoku Medical Megabank Organization (ToMMo), Tohoku University, Sendai, Japan.
Ota Wang V; Office of Data Sharing, National Cancer Institute, NIH, Rockville, MD, USA.
Paglione LD; Spherical Cow Group, Rego Park, NY 11374, USA.
Pandya RN; Microsoft Research, Redmond, WA 98052, USA.
Parkinson H; European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Philippakis AA; Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.
Prasser F; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Rambla J; Centre de Regulació Genòmica (CRG), Barcelona, Spain.
Reinold K; Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.
Rushton GA; Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.
Saltzman A; Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.
Saunders G; ELIXIR Hub, Wellcome Genome Campus, Hinxton, UK.
Sofia HJ; National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Spalding JD; European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Swertz MA; Genomics Coordination Center, Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Tulchinsky I; Google Cloud, Kitchener, ON N2H 5G5, Canada.
van Enckevort EJ; Genomics Coordination Center, Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Varma S; Health Data Research UK, Gibbs Building, 215 Euston Road, London NW1 2BE, UK.
Voisin C; Google Cloud, Kitchener, ON N2H 5G5, Canada.
Yamamoto N; Osaka University, Osaka, Japan.
Yamasaki C; Osaka University, Osaka, Japan.
Zass L; Computational Biology Division, IDM, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Guidry Auvil JM; Office of Data Sharing, National Cancer Institute, NIH, Rockville, MD, USA.
Nyrönen TH; ELIXIR-Finland, CSC - IT Center for Science Ltd, Espoo, Finland.
Courtot M; European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
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Źródło:
Cell genomics [Cell Genom] 2021 Nov 10; Vol. 1 (2), pp. None. Date of Electronic Publication: 2021 Nov 10.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
GA4GH Passport standard for digital identity and access permissions.
Autorzy:
Voisin C; Google LLC, Kitchener, ON N2H 5G5, Canada.
Linden M; CSC-IT Center for Science, Espoo 02101, Finland.; ELIXIR Finland, Espoo 02101, Finland.
Dyke SOM; McGill Centre for Integrative Neuroscience, McGill University, Montreal, QC H3A 2B4, Canada.
Bowers SR; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Alper P; ELIXIR Luxembourg, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4367 Belvaux, Luxembourg.
Barkley MP; DNAstack, Toronto, ON M5H 1T1, Canada.
Bernick D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Chao J; Google LLC, Kitchener, ON N2H 5G5, Canada.
Courtot M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire CB10 1SD, UK.
Jeanson F; Datadex Inc., Toronto, ON M5V 0C4, Canada.
Konopko MA; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.; Global Alliance for Genomics and Health, Toronto, ON M5G 0A3, Canada.
Kuba M; Masaryk University, Brno 602 00, Czech Republic.
Lawson J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Leinonen J; CSC-IT Center for Science, Espoo 02101, Finland.
Li S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Global Alliance for Genomics and Health, Toronto, ON M5G 0A3, Canada.
Ota Wang V; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Philippakis AA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Reinold K; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Rushton GA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Spalding JD; CSC-IT Center for Science, Espoo 02101, Finland.; ELIXIR Finland, Espoo 02101, Finland.
Törnroos J; CSC-IT Center for Science, Espoo 02101, Finland.; ELIXIR Finland, Espoo 02101, Finland.
Tulchinsky I; Verily Life Sciences, South San Francisco, CA 94080, USA.
Guidry Auvil JM; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Nyrönen TH; CSC-IT Center for Science, Espoo 02101, Finland.; ELIXIR Finland, Espoo 02101, Finland.
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Źródło:
Cell genomics [Cell Genom] 2021 Nov 10; Vol. 1 (2), pp. None. Date of Electronic Publication: 2021 Nov 10.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
The genetic basis and cell of origin of mixed phenotype acute leukaemia.
Autorzy:
Alexander TB; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
Gu Z; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Iacobucci I; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Dickerson K; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Choi JK; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xu B; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Payne-Turner D; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yoshihara H; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Loh ML; Department of Pediatrics, Benioff Children's Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, USA.
Horan J; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Emory University School of Medicine, Department of Pediatrics, Atlanta, GA, USA.
Buldini B; Department of Women and Child Health, Hemato-Oncology Division, University of Padova, Padova, Italy.
Basso G; Department of Women and Child Health, Hemato-Oncology Division, University of Padova, Padova, Italy.
Elitzur S; Pediatric Hematology-Oncology, Schneider Children's Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
de Haas V; Prinses Maxima Centre, Utrecht, The Netherlands.
Zwaan CM; Prinses Maxima Centre, Utrecht, The Netherlands.; Department of Pediatric Oncology, Erasmus MC-Sophia, Rotterdam, The Netherlands.
Yeoh A; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Reinhardt D; Universitäts-Klinikum, Essen, Germany.
Tomizawa D; Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Kiyokawa N; Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
Lammens T; Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.
De Moerloose B; Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.
Catchpoole D; The Tumour Bank CCRU, The Kids Research Institute, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Hori H; Department of Pediatrics, Mie University, Tsu, Japan.
Moorman A; Wolfson Childhood Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK.
Moore AS; The University of Queensland Diamantina Institute & Children's Health, Brisbane, Queensland, Australia.
Hrusak O; Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
Meshinchi S; Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA, USA.; Children's Oncology Group, Arcadia, CA, USA.
Orgel E; Children's Center for Cancer and Blood Disease, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Devidas M; University of Florida, Gainesville, FL, USA.
Borowitz M; Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Wood B; University of Washington, Seattle, WA, USA.
Heerema NA; The Ohio State University School of Medicine, Columbus, OH, USA.
Carrol A; University of Alabama at Birmingham, Birmingham, AL, USA.
Yang YL; Department of Laboratory Medicine and Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Smith MA; Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA.
Davidsen TM; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Rockville, MD, USA.
Hermida LC; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD, USA.
Gesuwan P; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD, USA.
Marra MA; Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
Ma Y; Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
Mungall AJ; Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
Moore RA; Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
Jones SJM; Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
Valentine M; Cytogenetics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN, USA.
Janke LJ; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Rubnitz JE; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Pui CH; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ding L; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Liu Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Nichols KE; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Downing JR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cao X; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Shi L; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Pounds S; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Newman S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Pei D; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Guidry Auvil JM; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD, USA.
Gerhard DS; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD, USA.
Hunger SP; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Inaba H; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA. .
Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA. .
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Źródło:
Nature [Nature] 2018 Oct; Vol. 562 (7727), pp. 373-379. Date of Electronic Publication: 2018 Sep 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Leukemia, Biphenotypic, Acute/*genetics
Leukemia, Biphenotypic, Acute/*pathology
Cell Lineage/genetics ; DNA Mutational Analysis ; Female ; Genetic Variation/genetics ; Genome, Human/genetics ; Genomics ; Humans ; Immunophenotyping ; Leukemia, Biphenotypic, Acute/classification ; Male ; Models, Genetic ; Mutation/genetics ; Neoplastic Stem Cells/immunology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Phenotype ; Trans-Activators/genetics
Czasopismo naukowe
Tytuł:
Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.
Autorzy:
Ma X; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Liu Y; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Liu Y; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Alexandrov LB; Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
Edmonson MN; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Gawad C; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Zhou X; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Li Y; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Rusch MC; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Easton J; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Huether R; Independent Researcher, Chicago, Illinois 60654, USA.
Gonzalez-Pena V; Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Wilkinson MR; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Hermida LC; Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Davis S; Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
Sioson E; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Pounds S; Department of Biostatistics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Cao X; Department of Biostatistics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Ries RE; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Wang Z; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Chen X; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Dong L; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Diskin SJ; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Smith MA; Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland 20892, USA.
Guidry Auvil JM; Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Meltzer PS; Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
Lau CC; Division of Hematology-Oncology, Connecticut Children's Medical Center, Hartford, Connecticut 06106, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032, USA.
Perlman EJ; Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Robert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois 60208, USA.
Maris JM; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Meshinchi S; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Hunger SP; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Gerhard DS; Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Zhang J; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
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Źródło:
Nature [Nature] 2018 Mar 15; Vol. 555 (7696), pp. 371-376. Date of Electronic Publication: 2018 Feb 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Profiling*
Gene Expression Regulation, Neoplastic*
Genome, Human/*genetics
Leukemia/*genetics
Mutation/*genetics
Neoplasms/*genetics
Alleles ; Aneuploidy ; Child ; DNA Copy Number Variations ; Exome/genetics ; Humans ; Mutation/radiation effects ; Mutation Rate ; Oncogenes/genetics ; Precision Medicine/trends ; Ultraviolet Rays/adverse effects
Czasopismo naukowe
Tytuł:
MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma.
Autorzy:
Zhang S; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA; Program in Bioinformatics, Boston University, Boston, MA 02218, USA.
Wei JS; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Li SQ; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Badgett TC; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA; Pediatric Hematology and Oncology, Kentucky Children's Hospital, Lexington, KY 40536, USA.
Song YK; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Agarwal S; Texas Children's Cancer Center, Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Coarfa C; Texas Children's Cancer Center, Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Tolman C; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Hurd L; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Liao H; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
He J; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Wen X; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Liu Z; Cell & Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Thiele CJ; Cell & Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Westermann F; Neuroblastoma Genomics, B030, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Asgharzadeh S; Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Seeger RC; Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Maris JM; Center for Childhood Cancer Research, the Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Oncology, the Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA.
Guidry Auvil JM; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD 20892, USA.
Smith MA; Clinical Investigation Branch, National Cancer Institute, Rockville, MD 20850, USA.
Kolaczyk ED; Program in Bioinformatics, Boston University, Boston, MA 02218, USA; Department of Mathematics & Statistics, Boston University, Boston, MA 02218, USA.
Shohet J; Texas Children's Cancer Center, Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Khan J; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA. Electronic address: .
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Źródło:
Cancer letters [Cancer Lett] 2016 Feb 28; Vol. 371 (2), pp. 214-24. Date of Electronic Publication: 2015 Dec 10.
Typ publikacji:
Journal Article
MeSH Terms:
Alternative Splicing*
Biomarkers, Tumor/*genetics
Neuroblastoma/*genetics
Nuclear Proteins/*genetics
Oncogene Proteins/*genetics
RNA, Neoplasm/*genetics
Binding Sites ; Biomarkers, Tumor/metabolism ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Chromatin Immunoprecipitation ; Gene Amplification ; Gene Expression Regulation, Neoplastic ; Heterogeneous Nuclear Ribonucleoprotein A1 ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/metabolism ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; High-Throughput Nucleotide Sequencing ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; N-Myc Proto-Oncogene Protein ; Neoplasm Staging ; Neuroblastoma/metabolism ; Neuroblastoma/mortality ; Nuclear Proteins/metabolism ; Oncogene Proteins/metabolism ; Polypyrimidine Tract-Binding Protein/genetics ; Polypyrimidine Tract-Binding Protein/metabolism ; Promoter Regions, Genetic ; RNA Interference ; RNA, Neoplasm/metabolism ; Risk Factors ; Thyroid Hormones/genetics ; Thyroid Hormones/metabolism ; Transcription, Genetic ; Transfection ; Thyroid Hormone-Binding Proteins
Czasopismo naukowe
Tytuł:
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.
Autorzy:
Oldridge DA; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.; Medical Scientist Training Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Wood AC; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, Auckland Region 1142, New Zealand.
Weichert-Leahey N; Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Crimmins I; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Sussman R; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Winter C; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
McDaniel LD; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Diamond M; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Hart LS; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Zhu S; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Durbin AD; Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Abraham BJ; Whitehead Institute for Biomedical Research and MIT, Boston, Massachusetts 02142, USA.
Anders L; Whitehead Institute for Biomedical Research and MIT, Boston, Massachusetts 02142, USA.
Tian L; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Zhang S; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
Wei JS; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
Khan J; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
Bramlett K; Thermo Fisher Scientific, Austin, Texas 78744, USA.
Rahman N; The Institute of Cancer Research, London SM2 5NG, UK.
Capasso M; University of Naples Federico II, 80131 Naples, Italy.; CEINGE Biotecnologie Avanzate, 80131 Naples, Italy.
Iolascon A; University of Naples Federico II, 80131 Naples, Italy.; CEINGE Biotecnologie Avanzate, 80131 Naples, Italy.
Gerhard DS; Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Guidry Auvil JM; Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Young RA; Whitehead Institute for Biomedical Research and MIT, Boston, Massachusetts 02142, USA.
Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Diskin SJ; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA.
Look AT; Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Maris JM; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA.
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Źródło:
Nature [Nature] 2015 Dec 17; Vol. 528 (7582), pp. 418-21. Date of Electronic Publication: 2015 Nov 11.
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA-Binding Proteins/*genetics
Enhancer Elements, Genetic/*genetics
Genetic Predisposition to Disease/*genetics
LIM Domain Proteins/*genetics
Neuroblastoma/*genetics
Polymorphism, Single Nucleotide/*genetics
Transcription Factors/*genetics
Acetylation ; Alleles ; Allelic Imbalance ; Binding Sites ; Epigenomics ; GATA3 Transcription Factor/metabolism ; Gene Expression Regulation, Neoplastic/genetics ; Genome-Wide Association Study ; Genotype ; Histones/chemistry ; Histones/metabolism ; Humans ; Introns/genetics ; Lysine/metabolism ; Organ Specificity ; Reproducibility of Results
Czasopismo naukowe
Tytuł:
MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours.
Autorzy:
Perlman EJ; Department of Pathology, Ann &Robert H. Lurie Children's Hospital of Chicago, Northwestern University's Feinberg School of Medicine, 225 E. Chicago Ave, Chicago, Illinosis 60611, USA.
Gadd S; Department of Pathology, Ann &Robert H. Lurie Children's Hospital of Chicago, Northwestern University's Feinberg School of Medicine, 225 E. Chicago Ave, Chicago, Illinosis 60611, USA.
Arold ST; King Abdullah University of Science and Technology, Department of Biochemistry and Molecular Biology, Division of Biological and Environmental Sciences and Engineering, Computational Bioscience Research Center, Thuwal 23955, Saudi Arabia.
Radhakrishnan A; King Abdullah University of Science and Technology, Department of Biochemistry and Molecular Biology, Division of Biological and Environmental Sciences and Engineering, Computational Bioscience Research Center, Thuwal 23955, Saudi Arabia.
Gerhard DS; Office of Cancer Genomics, National Cancer Institute, 31 Center Drive, Bethesda, Maryland 20892, USA.
Jennings L; Department of Pathology, Ann &Robert H. Lurie Children's Hospital of Chicago, Northwestern University's Feinberg School of Medicine, 225 E. Chicago Ave, Chicago, Illinosis 60611, USA.
Huff V; Department of Genetics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030, USA.
Guidry Auvil JM; Office of Cancer Genomics, National Cancer Institute, 31 Center Drive, Bethesda, Maryland 20892, USA.
Davidsen TM; Office of Cancer Genomics, National Cancer Institute, 31 Center Drive, Bethesda, Maryland 20892, USA.
Dome JS; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Children's National Medical Center, 111 Michigan Avenue, NW, Washington DC 20010, USA.
Meerzaman D; Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, Maryland 20892, USA.
Hsu CH; Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, Maryland 20892, USA.
Nguyen C; Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, Maryland 20892, USA.
Anderson J; Frontier Science and Technology Research Foundation, 505 S. Rosa Rd #100, Madison, Wisconsin 53719, USA.
Ma Y; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4S6.
Mungall AJ; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4S6.
Moore RA; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4S6.
Marra MA; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4S6.
Mullighan CG; Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 342, Memphis, Tennessee 38105, USA.
Ma J; Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 342, Memphis, Tennessee 38105, USA.
Wheeler DA; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, Ohio 43205, USA.
Hampton OA; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, Ohio 43205, USA.
Gastier-Foster JM; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.; Departments of Pathology and Pediatrics, Ohio State University College of Medicine, 700 Children's Drive, Columbus, Ohio 43205, USA.
Ross N; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Smith MA; Cancer Therapy Evaluation Program, National Cancer Institute, 9609 Medical Center Drive, RM 5-W414, MSC 9737, Bethesda, Maryland 20892, USA.
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Źródło:
Nature communications [Nat Commun] 2015 Dec 04; Vol. 6, pp. 10013. Date of Electronic Publication: 2015 Dec 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Kidney Neoplasms/*genetics
Neoplasm Proteins/*genetics
Nuclear Proteins/*genetics
Transcription Factors/*genetics
Wilms Tumor/*genetics
Cohort Studies ; Histones/genetics ; Histones/metabolism ; Humans ; Kidney/metabolism ; Kidney Neoplasms/metabolism ; Mutation ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/metabolism ; Nuclear Proteins/chemistry ; Nuclear Proteins/metabolism ; Protein Binding ; Protein Structure, Tertiary ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Transcription Factors/chemistry ; Transcription Factors/metabolism ; Wilms Tumor/metabolism
Czasopismo naukowe
Tytuł:
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations.
Autorzy:
Eleveld TF; Department of Oncogenomics, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Oldridge DA; 1] Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [2] Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [3] Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Bernard V; ICGEX Platform, Institut Curie, Paris, France.
Koster J; Department of Oncogenomics, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Colmet Daage L; 1] ICGEX Platform, Institut Curie, Paris, France. [2] Laboratory RTOP (Recherche Translationelle en Oncologie Pédiatrique), Transfer Department, Institut Curie, Paris, France.
Diskin SJ; 1] Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [2] Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [3] Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Schild L; Department of Oncogenomics, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Bentahar NB; ICGEX Platform, Institut Curie, Paris, France.
Bellini A; Laboratory RTOP (Recherche Translationelle en Oncologie Pédiatrique), Transfer Department, Institut Curie, Paris, France.
Chicard M; Laboratory RTOP (Recherche Translationelle en Oncologie Pédiatrique), Transfer Department, Institut Curie, Paris, France.
Lapouble E; Unité de Génétique Somatique, Institut Curie, Paris, France.
Combaret V; Centre Léon-Bérard, Laboratoire de Recherche Translationnelle Lyon, Lyon, France.
Legoix-Né P; ICGEX Platform, Institut Curie, Paris, France.
Michon J; Département de Pédiatrie, Institut Curie, Paris, France.
Pugh TJ; Princess Margaret Cancer Centre, University Health Network; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Hart LS; 1] Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [2] Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Rader J; 1] Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [2] Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Attiyeh EF; 1] Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [2] Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [3] Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Wei JS; Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, US National Institutes of Health, Gaithersburg, Maryland, USA.
Zhang S; Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, US National Institutes of Health, Gaithersburg, Maryland, USA.
Naranjo A; Department of Biostatistics, University of Florida, Children's Oncology Group (COG), Gainesville, Florida, USA.
Gastier-Foster JM; 1] The Ohio State University College of Medicine, Columbus, Ohio, USA. [2] Biopathology Center, Nationwide Children's Hospital, Columbus, Ohio, USA.
Hogarty MD; 1] Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [2] Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [3] Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Asgharzadeh S; 1] Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, California, USA. [2] Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA. [3] Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Smith MA; Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA.
Guidry Auvil JM; Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland, USA.
Watkins TB; Translational Cancer Therapeutics Laboratory, Cancer Research UK, London, UK.
Zwijnenburg DA; Department of Oncogenomics, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Ebus ME; Department of Oncogenomics, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
van Sluis P; Department of Oncogenomics, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Hakkert A; Department of Oncogenomics, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
van Wezel E; 1] Department of Experimental Immunohematology, Sanquin Research, Amsterdam, the Netherlands. [2] Landsteiner Laboratory, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
van der Schoot CE; 1] Department of Experimental Immunohematology, Sanquin Research, Amsterdam, the Netherlands. [2] Landsteiner Laboratory, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Westerhout EM; Department of Oncogenomics, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Schulte JH; 1] Department of Pediatric Oncology and Hematology, Charité University Medicine, Berlin, Germany. [2] German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. [3] Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany. [4] Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.
Tytgat GA; Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Dolman ME; Department of Oncogenomics, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Janoueix-Lerosey I; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.
Gerhard DS; Biopathology Center, Nationwide Children's Hospital, Columbus, Ohio, USA.
Caron HN; Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Delattre O; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.
Khan J; Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, US National Institutes of Health, Gaithersburg, Maryland, USA.
Versteeg R; Department of Oncogenomics, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Schleiermacher G; 1] Laboratory RTOP (Recherche Translationelle en Oncologie Pédiatrique), Transfer Department, Institut Curie, Paris, France. [2] Département de Pédiatrie, Institut Curie, Paris, France. [3] INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.
Molenaar JJ; Department of Oncogenomics, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.
Maris JM; 1] Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [2] Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [3] Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
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Źródło:
Nature genetics [Nat Genet] 2015 Aug; Vol. 47 (8), pp. 864-71. Date of Electronic Publication: 2015 Jun 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
MAP Kinase Signaling System/*genetics
Mitogen-Activated Protein Kinases/*genetics
Neoplasm Recurrence, Local/*genetics
Neuroblastoma/*genetics
ras Proteins/*genetics
Anaplastic Lymphoma Kinase ; Animals ; Benzimidazoles/pharmacology ; Blotting, Western ; Cell Line, Tumor ; Child ; Child, Preschool ; Chromosome Aberrations ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Infant ; Male ; Mice, SCID ; Mitogen-Activated Protein Kinases/metabolism ; Neuroblastoma/drug therapy ; Neuroblastoma/pathology ; Phosphorylation/drug effects ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Xenograft Model Antitumor Assays ; ras Proteins/metabolism
Czasopismo naukowe
Tytuł:
Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.
Autorzy:
Ma X; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Edmonson M; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Yergeau D; Pediatric Cancer Genome Project Validation Lab, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Muzny DM; Cancer Genomics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Hampton OA; Cancer Genomics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Rusch M; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Song G; Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Easton J; Pediatric Cancer Genome Project Validation Lab, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Harvey RC; University of New Mexico Cancer Center, Albuquerque, New Mexico 87131, USA.
Wheeler DA; Cancer Genomics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Ma J; Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Doddapaneni H; Cancer Genomics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Vadodaria B; Pediatric Cancer Genome Project Validation Lab, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Wu G; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Nagahawatte P; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Carroll WL; Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY 10016, USA.
Chen IM; University of New Mexico Cancer Center, Albuquerque, New Mexico 87131, USA.
Gastier-Foster JM; 1] Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio 43205, USA [2] Departments of Pathology and Pediatrics, The Ohio State University, Columbus, Ohio 43210, USA.
Relling MV; Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Smith MA; Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland 20892, USA.
Devidas M; Department of Biostatistics, Colleges of Medicine, Public Health &Health Professions, University of Florida, Gainesville, Florida 32607, USA.
Guidry Auvil JM; Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Downing JR; Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Loh ML; Department of Pediatrics, Benioff Children's Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA.
Willman CL; University of New Mexico Cancer Center, Albuquerque, New Mexico 87131, USA.
Gerhard DS; Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Mullighan CG; Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Hunger SP; Division of Oncology and The Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Zhang J; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
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Źródło:
Nature communications [Nat Commun] 2015 Mar 19; Vol. 6, pp. 6604. Date of Electronic Publication: 2015 Mar 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Clonal Evolution/*genetics
Neoplasm Recurrence, Local/*genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
5'-Nucleotidase/genetics ; CREB-Binding Protein/genetics ; Child ; Clone Cells ; DNA Copy Number Variations ; Disease Progression ; Exome ; Extracellular Matrix Proteins/genetics ; Female ; GTP Phosphohydrolases/genetics ; Histone-Lysine N-Methyltransferase/genetics ; Humans ; Ikaros Transcription Factor/genetics ; Male ; Membrane Proteins/genetics ; Mutation ; Repressor Proteins/genetics ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł:
Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.
Autorzy:
Walz AL; Division of Hematology-Oncology and Transplantation, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University's Feinberg School of Medicine, Chicago, IL 60611, USA.
Ooms A; Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam CA 3000, the Netherlands.
Gadd S; Department of Pathology and Laboratory Medicine, Lurie Children's Hospital, Northwestern University's Feinberg School of Medicine and Robert H. Lurie Cancer Center, Chicago, IL 60611, USA.
Gerhard DS; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD 20892, USA.
Smith MA; Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD 20892, USA.
Guidry Auvil JM
Meerzaman D; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD 20892, USA.
Chen QR; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD 20892, USA.
Hsu CH; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD 20892, USA.
Yan C; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD 20892, USA.
Nguyen C; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD 20892, USA.
Hu Y; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD 20892, USA.
Bowlby R; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
Brooks D; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
Ma Y; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
Mungall AJ; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
Moore RA; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
Schein J; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
Marra MA; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC V5Z 4S6, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada.
Huff V; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Dome JS; Division of Pediatric Hematology/Oncology, Children's National Medical Center, Washington, DC 20010, USA.
Chi YY; Department of Biostatistics, University of Florida, Gainesville, FL 32610, USA.
Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ma J; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Wheeler DA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Hampton OA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Jafari N; Center for Genetic Medicine, Northwestern University, Chicago, IL 60611, USA.
Ross N; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, OH 43205, USA.
Gastier-Foster JM; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, OH 43205, USA.
Perlman EJ; Department of Pathology and Laboratory Medicine, Lurie Children's Hospital, Northwestern University's Feinberg School of Medicine and Robert H. Lurie Cancer Center, Chicago, IL 60611, USA. Electronic address: .
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Źródło:
Cancer cell [Cancer Cell] 2015 Feb 09; Vol. 27 (2), pp. 286-97.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Homeodomain Proteins/*genetics
Nerve Tissue Proteins/*genetics
RNA-Binding Proteins/*genetics
Ribonuclease III/*genetics
Wilms Tumor/*genetics
Gene Expression Regulation, Neoplastic ; Humans ; Loss of Heterozygosity/genetics ; MicroRNAs/genetics ; Mutation ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Polymorphism, Single Nucleotide ; Wilms Tumor/pathology
Czasopismo naukowe
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