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    Tytuł:
    Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.
    Autorzy:
    Ortiz D; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America.
    Guiguemde WA; Department of Chemical Biology and Theraputics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Hammill JT; Department of Chemical Biology and Theraputics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Carrillo AK; Department of Chemical Biology and Theraputics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Chen Y; Department of Chemical Biology and Theraputics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Connelly M; Department of Chemical Biology and Theraputics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Stalheim K; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America.
    Elya C; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America.
    Johnson A; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America.
    Min J; Department of Chemical Biology and Theraputics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Shelat A; Department of Chemical Biology and Theraputics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Smithson DC; Department of Chemical Biology and Theraputics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Yang L; Department of Chemical Biology and Theraputics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Zhu F; Department of Chemical Biology and Theraputics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Guy RK; Department of Chemical Biology and Theraputics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Landfear SM; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America.
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    Źródło:
    PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2017 Dec 29; Vol. 11 (12), pp. e0006157. Date of Electronic Publication: 2017 Dec 29 (Print Publication: 2017).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antiprotozoal Agents/*pharmacokinetics
    Drug Evaluation, Preclinical/*methods
    Leishmania mexicana/*drug effects
    Leishmaniasis, Cutaneous/*drug therapy
    Administration, Oral ; Animals ; Antiprotozoal Agents/administration & dosage ; Antiprotozoal Agents/adverse effects ; Antiprotozoal Agents/chemistry ; Cell Line ; Chemistry, Pharmaceutical ; Drug Discovery ; Female ; Humans ; Leishmania mexicana/growth & development ; Leishmaniasis, Cutaneous/parasitology ; Macrophages/parasitology ; Mice ; Mice, Inbred BALB C ; Phenotype
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
    Autorzy:
    Van Voorhis WC; Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America.
    Adams JH; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America.
    Adelfio R; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
    Ahyong V; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America.
    Akabas MH; Departments of Physiology & Biophysics, Neuroscience and Medicine, Albert Einstein College of Medicine, New York, New York, United States of America.
    Alano P; Dipartimento Malattie Infettive, Parassitarie ed Immunomediate Istituto Superiore di Sanità, Roma, Italia.
    Alday A; BBD BioPhenix SL-BIOBIDE, Donostia, Gipuzkoa, Spain.
    Alemán Resto Y; Bigelow Laboratory for Ocean Sciences, East Boothbay, Maine, United States of America.
    Alsibaee A; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
    Alzualde A; BBD BioPhenix SL-BIOBIDE, Donostia, Gipuzkoa, Spain.
    Andrews KT; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.; QIMR Berghofer Medical Research Institute Herston, Brisbane, Australia.
    Avery SV; School of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, England, United Kingdom.
    Avery VM; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.
    Ayong L; Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea.
    Baker M; Clinical Pharmacology, Novartis Consumer Health, Nyon, Switzerland.
    Baker S; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, Oxford University, Oxford, England, United Kingdom.; The London School of Hygiene and Tropical Medicine, London, England, United Kingdom.
    Ben Mamoun C; Internal Medicine, Yale University, New Haven, Connecticut, United States of America.
    Bhatia S; Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
    Bickle Q; Department of Immunology & Infection, London School of Hygiene and Tropical Medicine, London, England, United Kingdom.
    Bounaadja L; Museum of National History, Sorbonne Universities, Paris, France.
    Bowling T; SCYNEXIS, Inc., Durham, North Carolina, United States of America.
    Bosch J; Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America.
    Boucher LE; Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America.
    Boyom FF; Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon.
    Brea J; CIMUS Research Centre, University of Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.
    Brennan M; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
    Burton A; SCYNEXIS, Inc., Durham, North Carolina, United States of America.
    Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America.
    Camarda G; Dipartimento Malattie Infettive, Parassitarie ed Immunomediate Istituto Superiore di Sanità, Roma, Italia.
    Carrasquilla M; Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America.
    Carter D; School of Life and Environmental Sciences, University of Sydney, Darlington New South Wales, Australia.
    Belen Cassera M; Department of Biochemistry and Virginia Tech Center for Drug Discovery, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America.
    Chih-Chien Cheng K; National Center of Advancing Translational Sciences, NIH, Bethesda, Maryland, United States of America.
    Chindaudomsate W; Department of Biochemistry, Mahidol University, Bangkok, Thailand.
    Chubb A; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
    Colon BL; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America.
    Colón-López DD; Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America.
    Corbett Y; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy.
    Crowther GJ; Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America.
    Cowan N; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
    D'Alessandro S; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy.
    Le Dang N; Department of Pathology and Immunology, Washington University in St Louis, St. Louis, Missouri, United States of America.
    Delves M; Department of Life Sciences, Imperial College London, London, England, United Kingdom.
    DeRisi JL; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America.
    Du AY; Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America.
    Duffy S; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.
    Abd El-Salam El-Sayed S; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.; Department of Biochemistry and Chemistry of nutrition, Mansoura University, Mansoura City, Egypt.
    Ferdig MT; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame Indiana, United States of America.
    Fernández Robledo JA; Bigelow Laboratory for Ocean Sciences, East Boothbay, Maine, United States of America.
    Fidock DA; Department of Microbiology & Immunology and Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, United States of America.
    Florent I; Museum of National History, Sorbonne Universities, Paris, France.
    Fokou PV; Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon.
    Galstian A; Broad Institute, Cambridge, Massachusetts, United States of America.
    Gamo FJ; Biochemistry and Parasitology Department, Malaria DPU, Diseases of the Developing World (DDW), GlaxoSmithKline R&D, Tres Cantos, Madrid, Spain.
    Gokool S; Tropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex, England, United Kingdom.
    Gold B; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America.
    Golub T; Broad Institute, Cambridge, Massachusetts, United States of America.
    Goldgof GM; Medical Scientist Training Program, University of California, San Diego, San Diego, California, United States of America.
    Guha R; National Center of Advancing Translational Sciences, NIH, Bethesda, Maryland, United States of America.
    Guiguemde WA; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Gural N; Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
    Guy RK; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
    Hansen MA; Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea.
    Hanson KK; Dept. of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, San Antonio, Texas, United States of America.; Instituto de Medicina Molecular, Lisboa, Portugal.
    Hemphill A; Institute of Parasitology, University of Berne, Bern, Switzerland.
    Hooft van Huijsduijnen R; Medicines for Malaria Venture, Geneva, Switzerland.
    Horii T; Global Health Research Section, hhc Data Creation Center, Eisai Co., Ltd, Tsukuba-shi, Ibaraki, Japan.
    Horrocks P; Institute for Science and Technology in Medicine, Keele University, Keele, Staffordshire, United Kingdom.
    Hughes TB; Department of Pathology and Immunology, Washington University in St Louis, St. Louis, Missouri, United States of America.
    Huston C; Department of Medicine, College of Medicine, University of Vermont, Burlington, Vermont, United States of America.
    Igarashi I; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
    Ingram-Sieber K; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
    Itoe MA; Instituto de Medicina Molecular, Lisboa, Portugal.
    Jadhav A; National Center of Advancing Translational Sciences, NIH, Bethesda, Maryland, United States of America.
    Naranuntarat Jensen A; Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok Thailand.
    Jensen LT; Department of Biochemistry, Mahidol University, Bangkok, Thailand.
    Jiang RH; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America.
    Kaiser A; Medical Research Centre, Institute for Pharmacogenetics, Essen, Germany.
    Keiser J; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
    Ketas T; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America.
    Kicka S; Department of Biochemistry, University of Geneva, Geneva, Switzerland.
    Kim S; Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America.
    Kirk K; Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.
    Kumar VP; Internal Medicine, Yale University, New Haven, Connecticut, United States of America.
    Kyle DE; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America.
    Lafuente MJ; Biochemistry and Parasitology Department, Malaria DPU, Diseases of the Developing World (DDW), GlaxoSmithKline R&D, Tres Cantos, Madrid, Spain.
    Landfear S; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America.
    Lee N; Medicines for Malaria Venture, Geneva, Switzerland.
    Lee S; Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea.
    Lehane AM; Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.
    Li F; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America.
    Little D; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America.
    Liu L; Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America.
    Llinás M; Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America.
    Loza MI; CIMUS Research Centre, University of Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.
    Lubar A; Department of Medicine, University of California San Diego, San Diego, California, United States of America.
    Lucantoni L; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.
    Lucet I; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
    Maes L; University of Antwerp, Department of Biomedical Sciences, Antwerp, Belgium.
    Mancama D; Biosciences Unit, Council for Scientific and Industrial Research, Pretoria, South Africa.
    Mansour NR; Department of Immunology & Infection, London School of Hygiene and Tropical Medicine, London, England, United Kingdom.
    March S; Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
    McGowan S; Department of Microbiology, Monash University, Clayton, Australia.
    Medina Vera I; Instituto de Medicina Molecular, Lisboa, Portugal.
    Meister S; Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America.
    Mercer L; SCYNEXIS, Inc., Durham, North Carolina, United States of America.
    Mestres J; Chemotargets S.L. and Research Group on Systems Pharmacology, Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Institute of Medical Research and University Pompeu Fabra, Barcelona, Catalonia, Spain.
    Mfopa AN; Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon.
    Misra RN; Division of Cancer Therapeutics and Diagnosis, Drug Synthesis and Chemistry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
    Moon S; Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea.
    Moore JP; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America.
    Morais Rodrigues da Costa F; Graduate Program in Bioinformatics, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
    Müller J; Institute of Parasitology, University of Berne, Bern, Switzerland.
    Muriana A; BBD BioPhenix SL-BIOBIDE, Donostia, Gipuzkoa, Spain.
    Nakazawa Hewitt S; Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America.
    Nare B; SCYNEXIS, Inc., Durham, North Carolina, United States of America.
    Nathan C; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America.
    Narraidoo N; School of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, England, United Kingdom.
    Nawaratna S; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.; QIMR Berghofer Medical Research Institute Herston, Brisbane, Australia.
    Ojo KK; Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America.
    Ortiz D; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America.
    Panic G; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
    Papadatos G; ChEMBL group, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire, United Kingdom.
    Parapini S; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy.
    Patra K; Department of Medicine, University of California San Diego, San Diego, California, United States of America.
    Pham N; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.
    Prats S; Biochemistry and Parasitology Department, Malaria DPU, Diseases of the Developing World (DDW), GlaxoSmithKline R&D, Tres Cantos, Madrid, Spain.
    Plouffe DM; Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America.
    Poulsen SA; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.
    Pradhan A; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America.
    Quevedo C; BBD BioPhenix SL-BIOBIDE, Donostia, Gipuzkoa, Spain.
    Quinn RJ; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.
    Rice CA; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America.
    Abdo Rizk M; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.; Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura City, Egypt.
    Ruecker A; Department of Life Sciences, Imperial College London, London, England, United Kingdom.
    St Onge R; Department of Biochemistry and Stanford Genome Technology Center, Stanford University, Palo Alto, Calilfornia, United States of America.
    Salgado Ferreira R; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
    Samra J; Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America.
    Robinett NG; Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America.; Laboratoire de Chimie Moléculaire, CNRS,-UMR 7509, COB-IRJBD, Mulhouse Cedex, France.
    Schlecht U; Department of Biochemistry and Stanford Genome Technology Center, Stanford University, Palo Alto, Calilfornia, United States of America.
    Schmitt M; Laboratoire de Chimie Moléculaire, CNRS,-UMR 7509, COB-IRJBD, Mulhouse Cedex, France.
    Silva Villela F; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
    Silvestrini F; Dipartimento Malattie Infettive, Parassitarie ed Immunomediate Istituto Superiore di Sanità, Roma, Italia.
    Sinden R; The Jenner Institute, University of Oxford, Oxford, England, United Kingdom.
    Smith DA; Department of Chemistry, University of Capetown, Capetown, South Africa.
    Soldati T; Department of Biochemistry, University of Geneva, Geneva, Switzerland.
    Spitzmüller A; Chemotargets S.L. and Research Group on Systems Pharmacology, Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Institute of Medical Research and University Pompeu Fabra, Barcelona, Catalonia, Spain.
    Stamm SM; Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America.
    Sullivan DJ; H. Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America.
    Sullivan W; Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States of America.
    Suresh S; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
    Suzuki BM; Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America.
    Suzuki Y; Department of Synthetic Biology and Bioenergy, J. Craig Venter Institute, La Jolla, California, United States of America.
    Swamidass SJ; Department of Life Sciences, Imperial College London, London, England, United Kingdom.
    Taramelli D; Department of Pathology and Immunology, Washington University in St Louis, St. Louis, Missouri, United States of America.
    Tchokouaha LR; Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon.
    Theron A; Biosciences Unit, Council for Scientific and Industrial Research, Pretoria, South Africa.
    Thomas D; Broad Institute, Cambridge, Massachusetts, United States of America.
    Tonissen KF; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.; School of Natural Sciences, Griffith University, Nathan, Queensland, Australia.
    Townson S; Tropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex, England, United Kingdom.
    Tripathi AK; H. Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America.
    Trofimov V; Department of Biochemistry, University of Geneva, Geneva, Switzerland.
    Udenze KO; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America.
    Ullah I; Institute for Science and Technology in Medicine, Keele University, Keele, Staffordshire, United Kingdom.
    Vallieres C; School of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, England, United Kingdom.
    Vigil E; Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America.
    Vinetz JM; Department of Medicine, University of California San Diego, San Diego, California, United States of America.
    Voong Vinh P; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
    Vu H; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.
    Watanabe NA; Global Health Research Section, hhc Data Creation Center, Eisai Co., Ltd, Tsukuba-shi, Ibaraki, Japan.
    Weatherby K; School of Life and Environmental Sciences, University of Sydney, Darlington New South Wales, Australia.
    White PM; Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States of America.
    Wilks AF; Hudson Institute of Medical Research; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; SYNthesis Research, Parkville, Victoria, Australia.
    Winzeler EA; Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America.
    Wojcik E; Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America.
    Wree M; Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America.
    Wu W; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America.
    Yokoyama N; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
    Zollo PH; Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon.
    Abla N; Medicines for Malaria Venture, Geneva, Switzerland.
    Blasco B; Medicines for Malaria Venture, Geneva, Switzerland.
    Burrows J; Medicines for Malaria Venture, Geneva, Switzerland.
    Laleu B; Medicines for Malaria Venture, Geneva, Switzerland.
    Leroy D; Medicines for Malaria Venture, Geneva, Switzerland.
    Spangenberg T; Medicines for Malaria Venture, Geneva, Switzerland.
    Wells T; Medicines for Malaria Venture, Geneva, Switzerland.
    Willis PA; Medicines for Malaria Venture, Geneva, Switzerland.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2016 Jul 28; Vol. 12 (7), pp. e1005763. Date of Electronic Publication: 2016 Jul 28 (Print Publication: 2016).
    Typ publikacji:
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Datasets as Topic*
    Antimalarials/*therapeutic use
    Drug Discovery/*methods
    Malaria/*drug therapy
    Neglected Diseases/*drug therapy
    Drug Evaluation, Preclinical ; Humans ; Small Molecule Libraries
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds.
    Autorzy:
    Ortiz D; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America.
    Guiguemde WA; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, United States of America.
    Johnson A; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America.
    Elya C; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America.
    Anderson J; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America.
    Clark J; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, United States of America.
    Connelly M; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, United States of America.
    Yang L; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, United States of America.
    Min J; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, United States of America.
    Sato Y; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America.
    Guy RK; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, United States of America.
    Landfear SM; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America.
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    Źródło:
    PloS one [PLoS One] 2015 Apr 20; Vol. 10 (4), pp. e0123598. Date of Electronic Publication: 2015 Apr 20 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Antimalarials/*analysis
    Antimalarials/*pharmacology
    High-Throughput Screening Assays/*methods
    Monosaccharide Transport Proteins/*antagonists & inhibitors
    Plasmodium falciparum/*drug effects
    Protozoan Proteins/*antagonists & inhibitors
    Animals ; Antimalarials/pharmacokinetics ; Cell Proliferation/drug effects ; Erythrocytes/drug effects ; Erythrocytes/parasitology ; Glucose/metabolism ; Glucose Transporter Type 1/metabolism ; Humans ; Kinetics ; Male ; Mice ; Monosaccharide Transport Proteins/metabolism ; Parasites/drug effects ; Protozoan Proteins/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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