- Tytuł:
- 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.
- Autorzy:
- Źródło:
- Nature structural & molecular biology [Nat Struct Mol Biol] 2010 Jun; Vol. 17 (6), pp. 688-95. Date of Electronic Publication: 2010 May 09.
- Typ publikacji:
-
Journal Article; Research Support, N.I.
H ., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H .S.; Comment - MeSH Terms:
-
Genes, BRCA1*
Mutation*
BRCA1 Protein/*deficiency
BRCA1 Protein/*genetics
Breast Neoplasms/*genetics
Breast Neoplasms/*metabolism
Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors
Animals ; Apoptosis Regulatory Proteins ; BRCA2 Protein/deficiency ; BRCA2 Protein/genetics ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Cycle ; Cell Proliferation ; Chromosomal Proteins, Non-Histone ; DNA Damage ; DNA Repair ; DNA-Binding Proteins ; Drug Resistance, Neoplasm/genetics ; Drug Resistance, Neoplasm/physiology ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/metabolism ; Female ; Gene Deletion ; Genes, BRCA2 ; Humans ; Intracellular Signaling Peptides and Proteins/deficiency ; Intracellular Signaling Peptides and Proteins/genetics ; Mice ; Mice, Knockout ; Mutagenesis, Insertional ; Tumor Cells, Cultured ; Tumor Suppressor p53-Binding Protein 1
Czasopismo naukowe