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Wyświetlanie 1-5 z 5
Tytuł :
Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma.
Autorzy :
Echevarría‐Vargas, Ileabett M.
Reyes‐Uribe, Patricia I.
Guterres, Adam N.
Yin, Xiangfan
Kossenkov, Andrew V.
Liu, Qin
Zhang, Gao
Krepler, Clemens
Cheng, Chaoran
Wei, Zhi
Somasundaram, Rajasekharan
Karakousis, Giorgos
Xu, Wei
Morrissette, Jennifer J. D.
Lu, Yiling
Mills, Gordon B.
Sullivan, Ryan J.
Benchun, Miao
Frederick, Dennie T.
Boland, Genevieve
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Źródło :
EMBO Molecular Medicine; May2018, Vol. 10 Issue 5, p1-1, 15p
Czasopismo naukowe
Tytuł :
Targeting telomerase for cancer therapy.
Autorzy :
Guterres AN; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Villanueva J; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA. .; Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA. .
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Źródło :
Oncogene [Oncogene] 2020 Sep; Vol. 39 (36), pp. 5811-5824. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Review; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.
Autorzy :
Echevarría-Vargas IM; Molecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Reyes-Uribe PI; Molecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Guterres AN; Molecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Yin X; Molecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Kossenkov AV; Molecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Liu Q; Molecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Zhang G; Molecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Krepler C; Molecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Cheng C; College of Computing Sciences, New Jersey Institute of Technology, Newark, NJ, USA.
Wei Z; College of Computing Sciences, New Jersey Institute of Technology, Newark, NJ, USA.
Somasundaram R; Molecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Karakousis G; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Xu W; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Morrissette JJ; Center for Personalized Diagnostics, Hospital of the University of Pennsylvania University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Lu Y; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mills GB; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sullivan RJ; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Benchun M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Frederick DT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Boland G; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Flaherty KT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Weeraratna AT; Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA.; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Herlyn M; Molecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.; Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA.
Amaravadi R; Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Schuchter LM; Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Burd CE; Departments of Molecular Genetics and Cancer Biology and Genetics, Ohio State University, Columbus, OH, USA.
Aplin AE; Department of Cancer Biology and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Xu X; Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Villanueva J; Molecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA .; Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA.
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Źródło :
EMBO molecular medicine [EMBO Mol Med] 2018 May; Vol. 10 (5).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Xenograft Model Antitumor Assays*
Drug Resistance, Neoplasm/*drug effects
MAP Kinase Kinase 1/*antagonists & inhibitors
Melanoma/*drug therapy
Proteins/*antagonists & inhibitors
Skin Neoplasms/*drug therapy
Acetanilides/pharmacology ; Animals ; Cell Cycle Proteins ; Cell Line, Tumor ; Gene Expression Profiling/methods ; Heterocyclic Compounds, 3-Ring/pharmacology ; Humans ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Signaling System/drug effects ; Melanoma/genetics ; Melanoma/metabolism ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Protein Kinase Inhibitors/pharmacology ; Proteins/metabolism ; Proteomics/methods ; Salvage Therapy/methods ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
    Wyświetlanie 1-5 z 5

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